GBIME0099MR Ventilators Market to 2020 sample · Ventilators Market to 2020 Technical Advances and Hospital Expansion Serve as Distinct Regional Growth Drivers . ... between the patient

Ventilators Market to 2020 Technical Advances and Hospital Expansion Serve as Distinct Regional Growth Drivers

GBI Research Report Guidance

© GBI Research. This is a licensed product and is not to be photocopied GBIME0099MR / Published AUG 2014 Page 2

GBI Research Report Guidance

The report begins with an executive summary capturing the major factors driving the growth of the global ventilators market.

Chapter three provides an overview of Chronic Obstructive Pulmonary Disease (COPD).

Chapter four provides definitions of ventilators.

Chapter five provides information on the size of the market throughout the 2006–2013 and 2013–2020 period. The chapter also provides information on key company shares in the global ventilators market and discusses the key trends and market dynamics that are expected to impact future growth.

Chapter six gives information on the market size throughout the 2006–2013 and 2013–2020 period, in the US, Japan, Germany, the UK, France, Brazil, Italy, China, Canada, Australia, Spain and India, with cross-country analysis.

Chapter seven provides information on the healthcare reimbursement system for the US, and the top five countries of Europe.

Chapter eight comprises profiles of the leading companies in the ventilators market, outlining their products, features and benefits.

Chapter nine focuses on the pipeline products for each segment. The key pipeline products are listed and discussed in detail alongside product approval and expected launch dates.

Chapter 10 discusses the deals that took place in the ventilators market between 2009 and 2013.

© GBI Research. This is a licensed product and is not to be photocopied GBIME0099MR / Published AUG 2014

Page 3

Executive Summary

Executive Summary

Global Ventilators Market to See Significant Growth during the Forecast Period

The following figure shows the projected revenue growth of the global ventilators market during the 2013–2020 forecast period.

Ventilators Market, Global, Revenue ($m), 2013–2020

Base year market size (2013)

Projected market size by 2020 Historic CAGR

Forecast CAGR

Market scenario

Market share held by top five companies Extent of technical change

Source: GBI Research, Proprietary Database [Accessed June 2, 2014]

CAGR: Compound Annual Growth Rate

The global ventilators market was valued at $XXm in 2013 and is forecast to exceed $XX billion by 2020, increasing at a CAGR of XX%. The increasing prevalence of Chronic Obstructive Pulmonary Disease (COPD), especially in the population aged XX and above, will remain the major driver of growth. The high prevalence of COPD has led to an increase in critical care admissions, where the use of mechanical ventilation is common. The introduction of new technologies and ventilation modes that prevent lung injury, reduce the time that patients have to spend on mechanical ventilation and sedation, and improve the synchrony between the patient and ventilator, will be the other major drivers of growth. Emerging economies, especially India and China, present significant potential for growth and will increase the number of Intensive Care Unit (ICU) beds per XX population. The improving reimbursement scenario for ICU procedures in developed economies is another major factor that will drive growth. The lack of standardized nomenclature for different ventilation modes, which leads to confusion among even the most experienced critical care physicians, and the lack of abundant clinical evidence to support newer ventilation technology are the major restraints.

The global ventilators market was valued at $XX in 2013 and is forecast to exceed $XX billion by 2020, increasing at a CAGR of XX%.


Page 7

Table of Contents

1 Table of Contents

1 Table of Contents ................................................................................................................................. 7 1.1 List of Tables ............................................................................................................................. 9 1.2 List of Figures...........................................................................................................................10

2 Introduction........................................................................................................................................11 3 Respiratory Diseases – Overview .........................................................................................................12

3.1 Chronic Obstructive Pulmonary Disease – Epidemiology ...........................................................12 4 Global Ventilators Market: Definitions .................................................................................................13

4.1 Adult/Pediatric Ventilators .......................................................................................................13 4.2 Neonatal Ventilators ................................................................................................................13

4.2.1 Transport Ventilators ..........................................................................................................13 5 Global Ventilators Market: Market Characterization ............................................................................14

5.1 Global Ventilators Market, Revenue, 2006–2020 ......................................................................14 5.2 Ventilators Market, Global, Key Company Shares, 2013 ............................................................15 5.3 Ventilators Market, Key Trends ................................................................................................16

5.3.1 Companies Focus on Development of Multimodal Ventilators to Prevent Lung Injury and Asynchrony.........................................................................................................................16

5.3.2 Advancements in Software, Facial Masks and Home Ventilation to Drive Growth of Ventilators ........................................................................................................................................18

5.4 Market Dynamics .....................................................................................................................18 5.4.1 Market Drivers ...................................................................................................................19 5.4.2 Market Restraints ...............................................................................................................22

6 Global Ventilators Market: Country Analysis and Forecasts ..................................................................24 6.1 Ventilators Market: Cross-country Analysis ...............................................................................24 6.2 Historic and Forecast Revenue and Volume, by Country............................................................25

6.2.1 Ventilators Market, US, Revenue and Volume, 2006–2020 ...................................................25 6.2.2 Ventilators Market, Japan, Revenue and Volume, 2006–2020 ..............................................28 6.2.3 Ventilators Market, Germany, Revenue and Volume, 2006–2020 .........................................31 6.2.4 Ventilators Market, France, Revenue and Volume, 2006–2020 .............................................34 6.2.5 Ventilators Market, UK, Revenue and Volume, 2006–2020...................................................37 6.2.6 Ventilators Market, Spain, Revenue and Volume, 2006–2020...............................................40 6.2.7 Ventilators Market, Italy, Revenue and Volume, 2006–2020 ................................................43 6.2.8 Ventilators Market, Canada, Revenue and Volume, 2006–2020 ...........................................45 6.2.9 Ventilators Market, China, Revenue and Volume, 2006–2020 ..............................................47 6.2.10 Ventilators Market, Australia, Revenue and Volume, 2006–2020 .........................................49 6.2.11 Ventilators Market, India, Revenue and Volume 2006–2020 ................................................52 6.2.12 Ventilators Market, Brazil, Revenue and Volume, 2006–2020 ..............................................55

7 Global Ventilators Market: Reimbursement System .............................................................................58 7.1 US ...........................................................................................................................................58 7.2 Europe.....................................................................................................................................58

7.2.1 Germany ............................................................................................................................58 7.2.2 France ................................................................................................................................58 7.2.3 Spain ..................................................................................................................................59 7.2.4 UK ......................................................................................................................................59

8 Global Ventilators Market: Competitive Landscape ..............................................................................60 8.1 Comparison of Leading Adult, Pediatric and Neonatal Ventilators, 2014 ....................................60 8.2 Company Profiles .....................................................................................................................61

8.2.1 ResMed ..............................................................................................................................61 8.2.2 Philips Respironics (Subsidiary of Koninklijke Philips) ............................................................61 8.2.3 Covidien .............................................................................................................................62 8.2.4 Draegerwerk ......................................................................................................................62


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Table of Contents

8.2.5 GE Healthcare (Subsidiary of General Electric) .....................................................................63 8.2.6 CareFusion .........................................................................................................................63 8.2.7 Smiths Medical ...................................................................................................................64 8.2.8 Maquet ..............................................................................................................................64 8.2.9 Hamilton ............................................................................................................................65 8.2.10 Air Liquide ..........................................................................................................................65

9 Global Ventilators Market: Product Pipeline Analysis ...........................................................................66 9.1 Ventilators Market: List of Pipeline Products ............................................................................66 9.2 Ventilators Market: Profiles of Key Pipeline Products ................................................................66

9.2.1 Astral .................................................................................................................................66 9.2.2 HiFLO2 Responz ..................................................................................................................66 9.2.3 Mechanical Ventilator ........................................................................................................67 9.2.4 OneBreath Ventilator..........................................................................................................67 9.2.5 Portable Ventilator .............................................................................................................67 9.2.6 Ventilation Device...............................................................................................................68 9.2.7 Ventilator – Neonates .........................................................................................................68 9.2.8 Ventilator FRC ....................................................................................................................68 9.2.9 Ventilator FRC – Home Ventilation ......................................................................................69 9.2.10 WynVent ............................................................................................................................69

10 Global Ventilators Market: Consolidation Landscape............................................................................70 10.1 Key Deals, 2009–2014 ..............................................................................................................70

10.1.1 Medtronic to Acquire Covidien for $42.9 Billion ...................................................................70 10.1.2 CareFusion’s Acquisition of Intermed Equipamento Medico Hospitalar, Respiratory Device

Company ............................................................................................................................70 11 Appendix ............................................................................................................................................71

11.1 Abbreviations ..........................................................................................................................71 11.2 Bibliography ............................................................................................................................72 11.3 Research Methodology ............................................................................................................73

11.3.1 Secondary Research ............................................................................................................73 11.3.2 Primary Research ...............................................................................................................74 11.3.3 Models ...............................................................................................................................74 11.3.4 Forecasts ............................................................................................................................74 11.3.5 Expert Panel .......................................................................................................................75

11.4 Contact Us ...............................................................................................................................75 11.5 Disclaimer................................................................................................................................75


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Table of Contents

1.1 List of Tables

Table 1: Ventilators Market, Global, Chronic Obstructive Pulmonary Disease National Prevalence (%) and Patient Population (million), 2014 ..............................................................................................12

Table 2: Ventilators Market, Global, Revenue ($m) and Compound Annual Growth Rate (%), 2006–2020 .14 Table 3: Ventilators Market, Global, Key Company Share by Region (%), 2013 ..........................................16 Table 4: Ventilators Market, Examples of Ventilators with Adaptive Pressure Control Mode, 2014............17 Table 5: Ventilators Market, Global, Number of ICU Beds in Key Countries, 2014 ......................................20 Table 6: Mechanical Ventilators Market, China, Number of Hospitals, 2004–2013 ....................................21 Table 7: Ventilators Market, Global, Cross-country Analysis, 2006–2020 ..................................................24 Table 8: Ventilators Market, US, Revenue ($m), Volume (‘000) and Compound Annual Growth Rate (%),

2006–2020 ................................................................................................................................27 Table 9: Ventilators Market, Japan, Revenue ($m), Volume (‘000) and Compound Annual Growth Rate (%),

2006–2020 ................................................................................................................................30 Table 10: Ventilators Market, Germany, Revenue ($m), Volume (‘000) and Compound Annual Growth Rate

(%), 2006–2020 ..........................................................................................................................33 Table 11: Ventilators Market, France, Revenue ($m), Volume (Units) and Compound Annual Growth Rate

(%), 2006–2020 ..........................................................................................................................36 Table 12: Ventilators Market, UK, Revenue ($m), Volume (Units) and Compound Annual Growth Rate (%),

2006–2020 ................................................................................................................................39 Table 13: Ventilators Market, Spain, Revenue ($m) and Volume (Units), 2006–2020 ...................................42 Table 14: Ventilators Market, Italy, Revenue ($m), Volume (Units) and Compound Annual Growth Rate (%),

2006–2020 ................................................................................................................................45 Table 15: Ventilators Market, Canada, Revenue ($m), Volume (Units) and Compound Annual Growth Rate

(%), 2006–2020 ..........................................................................................................................47 Table 16: Ventilators Market, China, Revenue ($m), Volume (‘000) and Compound Annual Growth Rate (%),

2006–2020 ................................................................................................................................49 Table 17: Ventilators Market, Australia, Revenue ($m), Volume (Units) and Compound Annual Growth Rate

(%), 2006–2020 ..........................................................................................................................51 Table 18: Ventilators Market, India, Revenue ($m), Volume (‘000) and Compound Annual Growth Rate (%),

2006–2020 ................................................................................................................................54 Table 19: Ventilators Market, Brazil, Revenue ($m), Volume (‘000) and Compound Annual Growth Rate (%),

2006–2020 ................................................................................................................................57 Table 20: ResMed, Key Marketed Products, 2014.......................................................................................61 Table 21: Philips Respironics, Key Marketed Products, 2014 .......................................................................61 Table 22: Covidien, Key Marketed Products, 2014 ......................................................................................62 Table 23: Draegerwerk, Key Marketed Products, 2014 ...............................................................................62 Table 24: GE Healthcare, Key Marketed Products, 2014 .............................................................................63 Table 25: CareFusion, Key Marketed Products, 2014 ..................................................................................63 Table 26: Smiths Medical, Key Marketed Products, 2014 ............................................................................64 Table 27: Maquet, Key Marketed Products, 2014 .......................................................................................64 Table 28: Hamilton, Key Marketed Products, 2014 .....................................................................................65 Table 29: Air Liquide, Key Marketed Products, 2014 ...................................................................................65 Table 30: Ventilators Market, Global, List of Pipeline Products, 2014 ..........................................................66 Table 31: Astral, Product Status, 2014 .......................................................................................................66 Table 32: HiFLO2 Responz, Product Status, 2014 ........................................................................................67 Table 33: Mechanical Ventilator, Product Status, 2014 ...............................................................................67 Table 34: OneBreath Ventilator, Product Status, 2014................................................................................67 Table 35: Portable Ventilator, Product Status, 2014 ...................................................................................68 Table 36: Ventilation Device, Product Status, 2014 ....................................................................................68 Table 37: Ventilator – Neonates, Product Status, 2014 ...............................................................................68 Table 38: Ventilator FRC, Product Status, 2014 ..........................................................................................69 Table 39: Ventilator FRC – Home Ventilation, Product Status, 2014 ............................................................69 Table 40: WynVent, Product Status, 2014 ..................................................................................................69


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Table of Contents

1.2 List of Figures

Figure 1: Ventilators Market, Device Overview ........................................................................................13 Figure 2: Ventilators Market, Global, Revenue ($m), 2006–2020 .............................................................14 Figure 3: Ventilators Market, Global, Key Company Share by Region (%), 2013 ........................................15 Figure 4: Ventilators Market, Market Dynamics ......................................................................................18 Figure 5: Ventilators Market, Comparison of Invasive and Non-invasive Ventilation, 2014........................19 Figure 6: Mechanical Ventilators Market, China, Number of Hospitals (‘000), 2004–2013 ........................21 Figure 7: Ventilators Market, Global, Cross-country Analysis, Compound Annual Growth Rate (%), 2006–

2020 ........................................................................................................................................24 Figure 8: Ventilators Market, US, Cross-segment Analysis, Compound Annual Growth Rate (%), 2006–2020

................................................................................................................................................25 Figure 9: Ventilators Market, US, Revenue ($m) and Volume (‘000), 2006–2020 ......................................26 Figure 10: Ventilators Market, Japan, Cross-segment Analysis, Compound Annual Growth Rate (%), 2006–

2020 ........................................................................................................................................28 Figure 11: Ventilators Market, Japan, Revenue ($m) and Volume (‘000), 2006–2020 .................................29 Figure 12: Ventilators Market, Germany, Cross-segment Analysis, Compound Annual Growth Rate (%),

2006–2020...............................................................................................................................31 Figure 13: Ventilators Market, Germany, Revenue ($m) and Volume (‘000), 2006–2020 ............................32 Figure 14: Ventilators Market, France, Cross-segment Analysis, Compound Annual Growth Rate (%), 2006–

2020 ........................................................................................................................................34 Figure 15: Ventilators Market, France, Revenue ($m) and Volume (Units), 2006–2020 ...............................35 Figure 16: Ventilators Market, UK, Cross-segment Analysis, Compound Annual Growth Rate (%), 2006–2020

................................................................................................................................................37 Figure 17: Ventilators Market, UK, Revenue ($m) and Volume (Units), 2006–2020.....................................38 Figure 18: Ventilators Market, Spain, Cross-segment Analysis, Compound Annual Growth Rate (%), 2006–

2020 ........................................................................................................................................40 Figure 19: Ventilators Market, Spain, Revenue ($m) and Volume (Units), 2006–2020.................................41 Figure 20: Ventilators Market, Italy, Cross-segment Analysis, Compound Annual Growth Rate (%), 2006–

2020 ........................................................................................................................................43 Figure 21: Ventilators Market, Italy, Revenue ($m) and Volume (Units), 2006–2020 ..................................44 Figure 22: Ventilators Market, Canada, Cross-segment Analysis, Compound Annual Growth Rate (%), 2006–

2020 ........................................................................................................................................45 Figure 23: Ventilators Market, Canada, Revenue ($m) and Volume (Units), 2006–2020..............................46 Figure 24: Ventilators Market, China, Cross-segment Analysis, Compound Annual Growth Rate (%), 2006–

2020 ........................................................................................................................................47 Figure 25: Ventilators Market, China, Revenue ($m) and Volume (‘000), 2006–2020 ..................................48 Figure 26: Ventilators Market, Australia, Cross-segment Analysis, Compound Annual Growth Rate (%),

2006–2020...............................................................................................................................49 Figure 27: Ventilators Market, Australia, Revenue ($m) and Volume (Units), 2006–2020 ...........................50 Figure 28: Ventilators Market, India, Cross-segment Analysis, Compound Annual Growth Rate (%), 2006–

2020 ........................................................................................................................................52 Figure 29: Ventilators Market, India, Revenue ($m) and Volume (‘000), 2006–2020 ...................................53 Figure 30: Ventilators Market, Brazil, Cross-segment Analysis, Compound Annual Growth Rate (%), 2006–

2020 ........................................................................................................................................55 Figure 31: Ventilators Market, Brazil, Revenue ($m) and Volume (‘000), 2006–2020 ..................................56 Figure 32: Ventilators Market, Comparison of Leading Adult, Pediatric and Neonatal Ventilators, 2014......60


Page 11

Introduction

2 Introduction

The global ventilators market is expected to witness moderate growth as a result of the rising prevalence of chronic heart and lung diseases and the increasing number of hospitals. The increased preference for home ventilation by clinicians and patients, to minimize hospital expenses, is catalyzing the demand for the home ventilators market.

This report categorizes the ventilators market into three segments: adult/pediatric ventilators, neonatal ventilators and transport ventilators.


Page 14

Global Ventilators Market: Market Characterization

5 Global Ventilators Market: Market Characterization

5.1 Global Ventilators Market, Revenue, 2006–2020

The following figure shows the revenue generated by the global ventilators market over the 2006–2020 period.

Figure 2: Ventilators Market, Global, Revenue ($m), 2006–2020

2006

2007

2008

2009

2010

2011

2012

2013

2014

2015

2016

2017

2018

2019

2020

Rev

enue

($m

)

Adult/pediatric ventilators Neonatal ventilators Transport ventilators


The following table shows the revenue generated by the global ventilators device market in the 2006–2020 period.

Table 2: Ventilators Market, Global, Revenue ($m) and Compound Annual Growth Rate (%), 2006–2020

2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 2020 Historic

CAGR (%)

Forecast CAGR

(%)

Adult/pediatric ventilators

Neonatal ventilators

Transport ventilators

Total

Source: GBI Research Proprietary Database [Accessed June 2, 2014]


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Global Ventilators Market: Market Characterization

The global market for ventilators was valued at $XXm in 2013 and is forecast to exceed $XX billion by 2020 at a CAGR of XX%. The high prevalence of COPD worldwide will be the major driving factor of the mechanical ventilation market. Supply-side initiatives to introduce new technologies and ventilation modes to prevent lung injury, improve the synchrony between the respiratory mechanics of the patient and the ventilation, and provide better patient comfort, by reducing the time a patient has to spend on mechanical ventilation and sedation, will be the other major drivers of the growth of the ventilator market. An increase in the number of hospitals, and hence ICU beds, in emerging economies will be another major driving factor, and improvements to the reimbursement system for ICU procedures in developed economies will continue to drive growth.

Multiple naming conventions used to identify ventilation modes is a major restraint as it creates confusion even among experienced ICU staff. Moreover, lack of clinical evidence is limiting adoption of newer technologies as critical care physicians are wary of the benefits associated with them.

A lack of standardized nomenclature for different ventilation modes has caused confusion, even among the most experienced critical care physicians, and, along with a lack of abundant clinical evidence to support newer technologies in ventilation, is the major drawback restraining growth.

5.2 Ventilators Market, Global, Key Company Shares, 2013

The following figure shows the market shares of the key companies in the ventilators market in 2013.

Figure 3: Ventilators Market, Global, Key Company Share by Region (%), 2013

Draeger

Maquet

Hamilton Medical

GE Healthcare

Air Liquide

Covidien

CareFusion

Other

Europe

Covidien

Maquet

DraegerwerkCareFusion

Hamilton Medical

GE Healthcare

Other

US

Maquet

Covidien

Draeger Hamilton Medical

CareFusion

ResMed

Philips Respironics

GE Healthcare

Other

Global

Maquet

CareFusion

Draeger

CovidienResMed

Philips Respironics

Mindray

Aeonmed

Hamilton Medical

Other

Asia-Pacific


The high prevalence of COPD worldwide will be the major driving factor of the mechanical ventilation market.


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Appendix

11 Appendix

11.1 Abbreviations

A/C: Assist/Control

APAP: Automatic Positive Airway Pressure

APC: Adaptive Pressure Control

APOC: Acute Point Of Care

APRV: Airway Pressure-Release Ventilation

ASV: Adaptive Support Ventilation

CAGR: Compound Annual Growth Rate

COPD: Chronic Obstructive Pulmonary Disease

CPAP: Continuous Positive Airway Pressure

DRG: Diagnosis Related Groups

DuoPAP: Duo Positive Airway Pressure

FRC: Functional Residual Capacity

HFOV: High Frequency Oscillatory Ventilation

HRG: Healthcare Resource Groups

ICD-10: International Statistical Classification of Diseases and Related Health Problems 10th Revision

ICU: Intensive Care Unit

IV: Intravenous

NAVA: Neurally Adjusted Ventilatory Assist

NHS: National Health Service

NIV: Non-invasive Ventilation

OPS-301: Operations and Procedures Classification (Operationen- und Prozedurenschluessel)

PA: Proportional Assist

PAV: Proportional Assist Ventilation

PC: Pressure Control

PCV+: Pressure Control Ventilation Plus

PS: Pressure Supported

PSV: Pressure Support Ventilation

SDB: Sleep-Disordered Breathing

SIMV: Synchronized Intermittent Mandatory Ventilation

SPONT/SPN: Spontaneous

TISS-28: Therapeutic Intervention Scoring System

VC: Volume Control

VPAP: Variable Positive Airway Pressure

VS: Volume Supported

VV: Volume Ventilation


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Appendix

11.2 Bibliography

AAST (2014). Critical Care Illness. American Association for the Surgery of Trauma. Available from: http://www.aast.org/generalinformation/criticalcareillness.aspx [Accessed on June 2, 2014].

ANZICS (2013). Profile of ICUs in Australia and New Zealand. Australian and New Zealand Intensive Care Society. Available from: http://www.anzics.com.au/downloads/cat_view/40-anzics/82-anzics-annual-reports [Accessed on June 2, 2014].

Bittner MI et al. (2013). Overview: key data regarding the healthcare system and intensive care units in the countries covered in this review. Annals of Intensive Care; 3:37

Buist AS et al. (2007). International variation in the prevalence of COPD (the BOLD Study): a population-based prevalence study. Lancet; 370(9589): 741–50

National Bureau of Statistics of China (2013).China Statistical Yearbook 2013. National Bureau of Statistics of China. Available from: http://www.stats.gov.cn/tjsj/ndsj/2013/indexeh.htm [Accessed on June 2, 2014].

Covidien (2014). Puritan Bennett™ 840 Ventilator. Covidien. Available from: http://www.covidien.com/rms/products/acute-platform-ventilation/puritan-bennett-pb840-ventilator#specifications [Accessed on June 2, 2014].

Demoule A et al. (2006). Increased use of non-invasive ventilation in French intensive care units. Intensive Care Med. November 2006; 32(11): 1747–55

Draegerwerk (2014). räger Evita Infinity® V500 ventilator. Draegerwerk. Available from: http://www.draeger.com/sites/en_uk/Pages/Hospital/Draeger-Evita-Infinity-V500-ventilator.aspx [Accessed June 2, 2014].

European Respiratory Society (2012), Respiratory burden ‘high in aging population’, Available from: http://www.erscongress2012.org/mediacenter/news-release/item/431-respiratory-burden-high-in-ageing-population-.html [Accessed June 2, 2014]

European COPD Coalition (2014). Prevalence in EU. European Chronic Obstructive Pulmonary Diseases Coalition. Available from: http://www.copdcoalition.eu/about-copd/prevalence [Accessed on June 2, 2014].

Galvin I (2010). Critical Care in Canada, University of Toronto. Critical Care. Available from: http://www.criticalcare.utoronto.ca/Assets/Critical+Care+Digital+Assets/Critical+Care/Critical+Care+Digital+Assets/fellowship/Critical+Care+Training+in+Canada.pdf

Halbert RJ et al. (2006). Global burden of COPD: systematic review and meta-analysis. The European Respiratory Journal, September; 28(3): 523–532

Hamilton Medical (2014). Technical Specifications. Hamilton Medical. Available from: http://medidyne.dk/wp-content/uploads/hamilton/respirator-s1/UK%20Hamilton%20S1%20Specs.pdf

Hope J (2010). Intensive care crisis: We have fewer beds than almost every other nation. Dailymail. Available from: http://www.dailymail.co.uk/health/article-1318945/Intensive-care-crisis-We-fewer-beds-nation.html [Accessed June 2, 2014].

Jayaram R and Ramakrishnan N (2008). Cost of intensive care in India. Indian Journal of Critical Care Medicine, April-June; 12(2): 55–61

Ling L et al. (2013), Critical care medicine in China: history and perspective, Chinese Medical Journal, 126(10)

Lung Foundation Australia (2014). COPD: The statistics. Lung Foundation Australia. Available from: http://lungfoundation.com.au/health-professionals/clinical-resources/copd/copd-the-statistics/ [Accessed on June 2, 2014].

Maheshwari V et al (2006). Utilization of non-invasive ventilation in acute care hospitals: a regional survey. Chest. May 2006; 129(5): 1226–33


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Appendix

Lujan M et al. (2006), Non-invasive home mechanical ventilation: Effectiveness and efficiency of an outpatient initiation protocol compared with the standard in-hospital model, Respiratory Medicine, Volume 101, Issue 6, Pages 1177–1182

Maquet (2014). Ventilation SERVO-U. Maquet. Available from: http://www.maquet.com/assets/documents/product-information/SERVO-u/c-Data-sheet-SERVO-U-en.pdf

Martin M (2013). Intensive Care Services resources in Spain. Medicina Intensiva, October 2013; 37(7)

Philips Respironics (2014). Respironics V200. Philips Respironics. Available from: http://www.healthcare.philips.com/main/products/hospital_respiratory/products/acute_care_ventilation/respironics_v200.wpd#&&/wEXAQUOY3VycmVudFRhYlBhdGgFFkRldGFpbHM6U3BlY2lmaWNhdGlvbnOKh+5fzpW/Rh82+nJNs/BzMC6HpA== [Accessed June 2, 2014].

Rennard S et al. (2006). COPD: the dangerous underestimate of 15%. The Lancet; 367(9518): 1216–1219

ResMed (2014). VPAP™ III ST-A. ResMed. Available from: http://www.resmed.com/content/dam/resmed/global/documents/products/machine/vpap-series/user-guide/248182_vpap-iii-sta_user-guide_amer_eng.pdf

Rhodes A et al. (2012). The variability of critical care bed numbers in Europe. European Society of Intensive Care Medicine; 38(10): 1647–1653

Silvio A (2014). Opening the Doors of the Intensive Care Unit to Patients With Hematologic Malignancies. Journal of Clinical Oncology; 34(11): 1169–1170

Statistics Canada (2012). Chronic obstructive pulmonary disease in Canadians, 2009 to 2011. Statistics Canada. Available from: http://www.statcan.gc.ca/pub/82-625-x/2012001/article/11709-eng.htm [Accessed on June 2, 2014].

UN (2014). World Population Ageing 2013. United Nations. Available from: http://www.un.org/en/development/desa/population/publications/pdf/ageing/WorldPopulationAgeing2013.pdf

WHO (2014). Chronic Obstructive Pulmonary Disease (COPD). World Health Organization. Available from: http://www.who.int/mediacentre/factsheets/fs315/en/ [Accessed on June 2, 2014].

WTC Buffalo Nigeria (2013). Medical Export China Access. World Trade Center Buffalo Nigeria. Available from: http://www.wtcbn.com/files/7413/8376/9337/MECA_Webinar4_November6_2013.pdf, [Accessed on April 17, 2014].

Yengkhom S (2013). ICU crisis hits state hospitals. The Times of India. Available from: http://timesofindia.indiatimes.com/city/kolkata/ICU-crisis-hits-state-hospitals/articleshow/17865518.cms [Accessed May 19, 2014].

11.3 Research Methodology

GBI Research’s dedicated research and analysis teams consist of experienced professionals with advanced statistical expertise and marketing, market research and consulting backgrounds in the medical devices industry.

GBI Research adheres to the codes of practice of the Market Research Society (www.mrs.org.uk) and Strategic and Competitive Intelligence Professionals (www.scip.org).

All GBI Research databases are continuously updated and revised. The following research methodology is followed for all databases and reports.

11.3.1 Secondary Research

The research process begins with extensive secondary research using internal and external sources to gather qualitative and quantitative information relating to each market.


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Appendix

The secondary research sources that are typically referred to include, but are not limited to:

Company websites, annual reports, financial reports, broker reports, investor presentations and SEC filings

Industry trade journals, scientific journals and other technical literature

Internal and external proprietary databases

Relevant patent and regulatory databases

National government documents, statistical databases and market reports

Procedure registries

News articles, press releases and web-casts specific to the companies operating in the market

11.3.2 Primary Research

GBI Research conducts hundreds of primary interviews a year with industry participants and commentators in order to validate its data and analysis. A typical research interview fulfills the following functions:

Provides first-hand information on market size, market trends, growth trends, competitive landscape and future outlook

Helps to validate and strengthen secondary research findings

Further develops the analysis team’s expertise and market understanding

Primary research involves email correspondence, telephone interviews and face-to-face interviews for each market, category, segment and sub-segment across a range of geographies.

The participants who typically take part in the process include, but are not limited to:

Industry participants: CEOs, VPs, marketing/product managers, market intelligence managers and national sales managers

Distributors, paramedics and representatives from hospital stores, laboratories and pharmacies

Outside experts: investment bankers, valuation experts, research analysts specializing in specific medical equipment markets

Key opinion leaders: physicians and surgeons that specialize in the therapeutic areas in which specific medical equipment is used

11.3.3 Models

Where no hard data is available GBI Research uses modeling and estimates in order to produce comprehensive data sets, for which the following rigorous methodology is adopted:

Available hard data is cross-referenced with the following data types to produce estimates:

Demographic data: population, split by segment

Macroeconomic indicators: GDP and inflation rate

Healthcare indicators: health expenditure, physician base, healthcare infrastructure and facilities

Selected epidemiological and procedure statistics

Data is then cross-checked by the expert panel. All data and assumptions relating to modeling are stored and are available to clients on request.

11.3.4 Forecasts

GBI Research uses proprietary forecast models, which utilize the following factors:

Historic growth rates

Macro indicators such as population trends and healthcare spending

Forecast epidemiological data


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Appendix

Qualitative trend information and assumptions

Data is then cross-checked by the expert panel.

11.3.5 Expert Panel

GBI Research uses a panel of experts to cross-verify its databases and forecasts.

GBI Research’s expert panel includes marketing managers, product specialists, international sales managers from medical device companies, academics from research universities, key opinion leaders from hospitals, consultants from venture capital funds and distributors/suppliers of medical equipment and supplies.

Historic data and forecasts are relayed to GBI Research’s expert panel for feedback and adjusted accordingly.

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