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GAMETE PRODUCTION IN SEXUAL REPRODUCTION MEIOSIS

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GAMETE PRODUCTION IN SEXUAL REPRODUCTION MEIOSIS Slide 2 What are chromosomes? Human cell = >6 billion nucleotide base pairs (~2 meters) Wrapped around protein = chromatin DNA/protein = chromosome Slide 3 How many chromosomes do humans have? Humans are diploid (2n) Two of each chromosome, one from each parent. n = 23 unique chromosomes (haploid #) 2(n) = 46 total chromosomes The two copies of each chromosome in human cells are homologous Curly hair allele Strait hair allele Slide 4 Families: similar yet different. Why? Single parent Offspring identical to each other and parent Sexual Reproduction Two parents Offspring are unique Offspring are similar to each other and parents Combine DNA from two individuals Combines characteristics of both individuals Asexual Reproduction Slide 5 MEIOSIS While mitosis conserves chromosome number, meiosis reduces the chromosome number by half Meiosis has a few stages: Interphase, Meiosis I, and Prophase I Metaphase I Anaphase I TelophaseI Meiosis II Prophase II Metaphase II Anaphase II Telophase II Slide 6 MEIOSIS INTERPHASE Interphase is similar to the process in mitosis The process results in two genetically identical sister chromatids The chromatids are connected at their centromeres Centrosomes also replicate Slide 7 PROPHASE I Chromosomes begin to condense Homologues (consisting of two sister chromatids) pair up When the chromosome pairs become visible, they show up as a tetrad, a cluster of four chromatids Homologous chromosomes can criss-cross, allowing the chromatids to switch segments, called crossing- over Slide 8 PROPHASE I continued Centrosomes move away from each other Microtubules form between the centrosomes Nuclear envelope and nucleoli disperse Prophase I can last for days or longer, and takes up 90% of the time required for meiosis Slide 9 METAPHASE I Chromosomes arrange on the metaphase plate (equator), still in homologous pairs Microtubules from one pole attach to one chromosome from each pair The other chromosome (homologous pair) is attached to a microtubule from the other pole Slide 10 ANAPHASE I The spindle apparatus guides the chromosomes towards the poles Sister chromatids remain attached at their centromeres The sister chromatids move together towards the same pole Slide 11 TELOPHASE I The homologous chromosome pairs continue to move apart to each pole Each pole contains a haploid (n) number of a chromosome set Cleavage furrows form in animal cells, and cell plates appear in plant cells Slide 12 TELOPHASE I AND CYTOKINESIS Cytokinesis usually occurs simultaneously with telophase I, forming two daughter cells There is no further replication of genetic material Depending on the species, the chromosomes de- condense and the nuclear membranes and nucleoli re-form. Slide 13 PROPHASE II A spindle apparatus forms The chromosomes progress towards the metaphase II plate (equator of the cell) Slide 14 METAPHASE II The chromosomes are positioned on the metaphase plate in mitosis-like fashion The microtubules attach to the centromeres of the sister chromatids Slide 15 ANAPHASE II The centromeres of the sister chromatids finally separate The sister chromatids of each pair, now individual chromosomes, move toward opposite poles of the cell Slide 16 TELOPHASE II AND CYTOKINESIS Nuclei form at opposite poles of the cell Cytokinesis occurs In the end, there are four daughter cells, each with the haploid number of un-replicated chromosomes