1

ASSOCIATION OF INDEPENDENT RESEARCH INSTITUTES

PRESENTATION

San Antonio TexasSeptember 24 – 26, 2007

2

FY 2008 PRESIDENT’S BUDGET REQUEST TOTAL NIH BUDGET AUTHORITY $28.850 BILLION

Research Mgmt. & Support 4.0%

All Other 5.0%

Other Research (inc Ks) 6.0%

Research Centers 10.0%

R&D Contracts 10.0%

Intramural Research 10.0%

Research Project Grants 52.0%

$15,165 Billion

Training 3.0% $761 Million

3

CHANGE IN NIH APPROPRIATIONS FY 1995 - 2008

$0

$5

$10

$15

$20

$25

$30

1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008

Pre-Doubling Period of Doubling Post Doubling

Billions

Fiscal Year

App

ropr

iatio

ns

0%

2%

4%

6%

8%

10%

12%

14%

16%

18%

Perc

ent C

hang

e

Appropriation Percent change from previous fiscal year

Source of Fiscal years 2007 and 2008 is FY 2008 President's Budget

4

NIH RESEARCH GRANTSFISCAL YEARS 1950 – 2006

$20.2

$1.7

0

3

6

9

12

15

18

21

1950

1952

1954

1956

1958

1960

1962

1964

1966

1968

1970

1972

1974

1976

1978

1980

1982

1984

1986

1988

1990

1992

1994

1996

1998

2000

2002

2004

2006

Am

ount

Aw

arde

d - B

illion

s

Current Dollars Constant Dollars

Constant dollars based on BRDPI FY 1950 = 100.0 FY 2006 =1216.6

5

NIH EXTRAMURAL AWARDS BY ACTIVITY FISCAL YEARS 1996 and 2006

Other R esearch

4%

Fellowships

1%

R esearch C areer

2%

SBIR -STTR

2% R esearch

C enters 10%

Other R esearch Projects

14%

T raining 3%

R 01 Eq uiv.51.3%

C ontracts16%

C onstr .0% Other

Activities 0%

Other Researc h

5.3%

Fellow s hips0.5%

Res earc h Career2.9%

SBIR-STTR2.7%

Res earc h Centers12.1%

Other Res earc h Projec ts18.7%

Training2.7%

R01 Equiv alents

45.3%

Contrac ts9.5%

Cons tr.0.2%

Other A c tiv ities

0.2%

FY 1996 $9.8 Billion

FY 2006 $23.2 Billion

6

6.6%6.4%6.3%6.5%6.6%6.8%6.5%6.4%

6.1%6.2%5.8%

0%

1%

2%

3%

4%

5%

6%

7%

8%

1996 $571

1997 $646

1998 $687

1999 $818

2000 $966

2001 $1,139

2002 $1,265

2003 $1,420

2004 $1,452

2005 $1,504

2006 $1,527

MIL L ION S

NIH SUPPORT TO AIRI MEMBERS PERCENT OF TOTAL EXTRAMURAL

7

NIH EXTRAMURAL AWARDS BY KIND OF INSTITUTIONFY 1996, 2001 and 2006

$0

$2,000

$4,000

$6,000

$8,000

$10,000

$12,000

$14,000

$16,000

$18,000

HigherE duc ation

A IRI M em bers Other Non-P rofit

Researc hIns titutes

For P rofitRes earc hIns titutes

O ther P rofit NonP rofitHospitals

OtherDom es t icNonP rofit

Foreign

1996 2001 2006

Mill

ions

8

EFFECTS OF INFLATION ON NIH AWARDS TO AIRI MEMBERS

$571

$1,527

$1,079

$0

$200

$400

$600

$800

$1,000

$1,200

$1,400

$1,600

$1,800

1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006

MIL

LIO

NS

Current Constant

Constant Dollars based on BRDPI FY 1996 = 100.0, FY 2006 = 141.5

9

NIH EXTRAMURAL AWARD TO AIRI MEMBERS Fiscal Years 1996 and 2006

Training1.3%

Fellow s hips0.8%

Other Res earc h

2.3%

Contrac ts5.1%

Res earc h Centers11.8%

Other Res earc h Projec ts21.2%

Res earc h Career1.0%

R01 Equiv alents

55.7%

Cons truc tion0.8%

SBIR-STTR0.1%

Other A c tiv ities

0.0%Oth e r

Activitie s0 .0%

Cons truc tion0%

Fellow s hips0%

R01 Equiv alents

43%

R e s ea rch C are e r12 .9 %

Oth e r R e s ea rch Pro jects25 .2%

R e s ea rch C e n te rs12 .1 %

C on tra cts4 .3%

Othe r R es e arch

2 .2%

SBIR -STTR0 .0%

Tra in ing0 .7 %

FY 2006 $1,527 Million

FY 1996 $571 Million

10

NIH EXTRAMURAL SUPPORT TO AIRI MEMBERS BY GRANT ACTIVITY

$0

$150

$300

$450

$600

$750

R01 E quiva lent R03 and R21 Other RP G ResearchC areer

Other ResearchGrants

Other A wards

MIL

LIO

NS

1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006

11

NIH AWARDS TO AIRI MEMBERS BY SUPPORTING INSTITUTE FY 2006

Total Support to Members - $1,526,747,972

NIAID $ 363,541,090 NEI $ 35,612,026 ORWH $ 8,079,658

NCI $ 357,561,457 NHGRI $ 34,085,694 NIBIB $ 3,659,624

NHLBI $ 150,338,671 NINH $ 31,424,115 OD $ 2,589,825

NIGMS $ 129,450,195 NIAMS $ 25,972,686 NINR $ 2,026,805

NIDDK $ 79,229,398 NIDA $ 21,717,846 NCCAM $ 1,650,934

NCRR $ 57,144,523 NIDCD $ 20,062,268 NLM $ 1,249,369

NINDS $ 56,845,513 NIAAA $ 19,285,629 FIC $ 898,059

NICHD $ 52,613,122 NIDCR $ 14,797,900 NCMHD $ 534,713

NIA $ 43,779,192 NIEHS $ 12,597,660

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AIRI Members accounted for 6.6% of NIH extramural funding

ORWH 90.6% NHLBI 5.9% NIDA 2.7%

NIAID 10.4% NIAAA 5.9% NIEHS 2.5%

NCI 9.9% NICHD 5.3% NINR 1.7%

NHGRI 8.6% NIDCR 5.2% NCCAM 1.6%

OD 7.6% NIDDK 5.1% NIBIB 1.3%

NIGMS 7.0% NIA 5.0% FIC 1.3%

NEI 6.5% NCRR 4.8% NLM 0.4%

NIDCD 6.3% NINDS 4.3% NCMHD 0.4%

NIAMS 6.2% NIMH 2.8%

PERCENT OF I/C EXTRAMURAL FUNDING AWARDED TO AIRI MEMBERS FY 2006

13

NIH TRAINING AND CAREER AWARDS TO AIRI MEMBERSFiscal Years 1996, 1999, 2002, 2005, 2006

$5.5

$7.4

$4.7

$8.8$9.4

$6.3

$17.9

$12.8

$5.6

$2 3 .6

$1 1 .9

$7 .6

$ 2 2 .5

$1 1 .4

$7 .5

0

5

10

15

20

25

Re se a rch Ca re e r Tra in ing G ra nts Fe llow ships

Mill

ion

s

F Y 1996 F Y 1999 FY 2002 FY 2005 F Y 2006

14

20,42119,255

17,705

0

3000

6000

9000

12000

15000

18000

21000

1990 1991 1992 1993 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007

Num

ber o

f App

licat

ions

Original Applications Amendments

NIH R01 EQUIVALENT (R01, R29 AND R37) COMPETING APPLICATIONS BY FISCAL YEAR OF REVIEW

15

New Applications

0%

10%

20%

30%

40%

50%

60%

1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006

Fiscal Years

Succ

ess

Rat

e

Non-Amended Amendments

SUCCESS RATES FOR NIH COMPETING R01 EQUIVALENT (R01, R29 AND R37) APPLICATIONS

16

Competing Continuations

0%

10%

20%

30%

40%

50%

60%

1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006

Fiscal Years

Succ

ess

Rat

e

Non-Amended Amendments

SUCCESS RATES FOR NIH COMPETING R01 EQUIVALENT (R01, R29 AND R37) APPLICATIONS

17

PERCENT OF R01 EQUIVALENT (R01, R29 AND R37) PROJECTS EVENTUALLY FUNDED BASED ON IRG ACTION OF ORIGINAL

(NON-AMENDMENT)

0%

10%

20%

30%

40%

50%

60%

70%

1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006

Scored Unscored

18

0

2,000

4,000

6,000

8,000

10,000

12,000

14,000

16,000

18,000

1990

1991

1992

1993

1994

1995

1996

1997

1998

1999

2000

2001

2002

2003

2004

2005

2006

2007

Review Year

Num

ber o

f App

licat

ions

Original New Applications Original Competing ContinuationsAmendments to New Applications Amendments to Competing Continuations

NIH COMPETING R01 EQUIVALENT (R01, R29 AND R37) APPLICATIONS BY YEAR OF REVIEW

19

SUCCESS RATES OF NIH COMPETING R01 EQUIVALENT (R01, R29 AND R37) APPLICATIONS

27.4%30.2% 30.9% 32.1% 32.0% 31.7% 30.7% 30.2%

25.4%22.7%

20.7%

35.0% 36.1%39.1%

37.4%38.8%

34.9%33.3%

36.4%

30.0%27.0%

23.7%

0%

5%

10%

15%

20%

25%

30%

35%

40%

45%

1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006

NIH Total AIRI

20

NIH R01 EQUIVALENT (R01, R29 AND R37) RESEARCH PROJECT APPLICATIONS FROM AIRI MEMBERS

878 907988 1,013

1,062 1,048 1,057

1,3381,415

1,475 1,458

307 327386 379 412

366 352

487425 398

346

0

200

400

600

800

1000

1200

1400

1600

1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006

Success Rate Base Awarded

21

NIH R01 EQUIVALENT (R01, R29 AND R37) AWARDS FY 2006

$248 $245$250$259

$242$252

$0

$25

$50

$75

$100

$125

$150

$175

$200

$225

$250

$275

All Institutions AIRI Members

THO

USA

ND

S

New Competing Continuation Noncompeting Continuations

Average Budgeted Direct Cost

22

NIH R01 EQUIVALENT (R01, R29 and R37) AWARDS AVERAGE TOTAL COST

  All Institutions AIRI Members

 FY Number Current DollarsConstant Dollars Number Current Dollars

Constant Dollars

1996 22190 $ 224,824 $ 224,824 1161 $ 270,825 $ 270,825

1997 23054 $ 233,797 $ 227,469 1249 $ 279,574 $ 272,008

1998 24205 $ 243,686 $ 229,315 1333 $ 288,122 $ 271,131

1999 25584 $ 259,077 $ 236,317 1425 $ 306,747 $ 279,799

2000 26860 $ 279,471 $ 245,761 1517 $ 326,801 $ 287,382

2001 27908 $ 300,657 $ 255,885 1579 $ 351,234 $ 298,929

2002 28781 $ 320,012 $ 263,625 1607 $ 370,959 $ 305,595

2003 29527 $ 337,324 $ 268,450 1708 $ 394,056 $ 313,599

2004 29857 $ 348,880 $ 267,674 1758 $ 402,518 $ 308,827

2005 29464 $ 358,757 $ 264,945 1785 $ 411,378 $ 303,806

2006 29039 $ 358,247 $ 253,185 1746 $ 414,440 $ 292,898

BRDPI Factor: FY 1996 = 100.0, FY 2006 = 141.5

23

INDIRECT COST (F&A) AS A PERCENT OF TOTAL COST

0%

5%

10%

15%

20%

25%

30%

35%

40%

1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006

AIRI Private Universities Public Universities Other Domestic Total

NIH Research Grants - Excludes awards with limited F&A reimbursement, foreign and federal institutions

24

TOTAL AWARDS RECEIVED BY AIRI MEMBERS

1996 1999 2004 2005 2006

2 1 2 2 Fred Hutchinson Cancer Research Center $ 251,416,555

1 2 1 1 Scripps Research Institute $ 214,321,359

3 3 3 3 Dana-Farber Cancer Institute $ 128,419,388

9 8 4 4 Gamble Program for Clinical Research at CHRF $ 83,984,690

10 9 6 5 Burnham Institute for Medical Research $ 66,235,933

7 6 5 7 The Jackson Laboratory $ 50,710,040

4 5 7 6 Salk Institute for Biological Studies $ 50,029,464

5 7 9 11 Fox Chase Cancer Center $ 36,992,516

42 12 10 8 Northern California Institute for Research and Education $ 35,385,432

11 11 12 13 The CBR Institute for Biomedical Research, Inc. $ 32,102,419

Ranks based on Total NIH Extramural Support Received

25

1,258 1,369 1,406 1,482 1,512 1,518 1,509 1,458 1,378 1,294

7476 91 75 80 60 63

8770

6360

1,591

0

200

400

600

800

1,000

1,200

1,400

1,600

1,800

1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006

Other AIRI

NUMBER OF FIRST TIME R01 EQUIVALENT (R01, R29 AND R37) AWARDEES

26

42.4

35.2

42.9

37.3

40.9

51.7

43.2

50.8

30

35

40

45

50

55

1970

1972

1974

1976

1978

1980

1982

1984

1986

1988

1990

1992

1994

1996

1998

2000

2002

2004

2006

Age

rage

age

Average Age of New investigators Average Age of All investigators

AVERAGE AGE OF COMPETING R01 EQUIVALENT (R01, R29 AND R37) AWARDEES

27

AGE OF COMPETING R01 EQUIVALENT (R01, R29 AND R37) AWARDEES

0%

20%

40%

60%

80%

100%

24 - 35 36 - 40 41 - 45 46 - 50 51 - 55 56 and Over

28

AGE OF COMPETING R01 EQUIVALENT (R01, R29 AND R37) AWARDEES - AIRI

0%

20%

40%

60%

80%

100%

24 - 35 36 - 40 41 - 45 46 - 50 51 - 55 55 an d o ver

29

AAMC Faculty Roster Data as of September 30, 2006

32

33

34

35

36

37

38

39

40

41

42

1980

1981

1982

1983

1984

1985

1986

1987

1988

1989

1990

1991

1992

1993

1994

1995

1996

1997

1998

1999

2000

2001

2002

2003

2004

2005

MD PhD MD/PhD

MD

PhDMD/PhD

Average Age at Time of First Assistant Professorship at US Medical Schools

30

SUCCESS RATES OF R01 EQUIVALENT (R01, R29 AND R37) APPLICATIONS BY TYPE AND AGE OF APPLICANT

0%

5%

10%

15%

20%

25%

30%

35%

40%

New Competing Continuations

35 and Under 36 - 40 41 - 45 46 - 50 51 - 55 56 - 60 61 - 65 66 and over

31

IN SUMMARYThe NIH budget increased a modest amount (2.4%) from FY 2006 to 2007

The period of doubling (FY 1998 - 2003) has ended!Research project grants continue to make up the bulk of NIH awards (64%)AIRI members received over $1.5 billion in NIH awards in FY 2006RPG's account for over 3/4 of NIH support to AIRI membersNIAID is the largest source of awards to AIRI members, while the Office of Research on Women's Health devotes the largest percent of their budget to AIRI.Research Career Awards have become the largest source of training/career development support to AIRI members

The number of original, unamended R01 equivalent applications has continued to fallProjects where the original was unscored have a much lower chance of eventual funding than scored originals

Success rates again fell in FY 2006. AIRI members continued to do better than the NIH averageThe average size of awards to AIRI members is nearly 16% higher than the overall NIH average, largely due to higher AIRI F&A rates

Fred Hutchinson Cancer Research Center is the largest recipient of NIH support among AIRI members in FY 2006In FY 2006, 74 members of AIRI received NIH supportNumber of first time investigators is relatively stable across yearsThe average age of principal investigators is continuing to climb, reaching 52 in FY 2005, matched by increasing age of first assistant professorship at medical schoolsInvestigators 35 years or younger account for 3 percent of NIH competing R01 equivalent awardsSuccess rates for new applications fall with increasing age of principal investigatorsA different source of information for R&D contracts was used in FY 2006,and data are not final

32

RESOURCES

NIH’S AWARD INFORMATION & DATA PAGE

AWARD DATA FOR INDIVIDUAL ORGANIZATIONSAGGREGATE DATAhttp://grants.nih.gov/grants/award/trends/AggregateData.cfm

http://grants.nih.gov/grants/award/award.htm

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THANK YOU