Futu

re o

f Life S

cie

nces:

Th

e g

rea

t co

nve

rge

nce

of

life

and

tech

nolo

gy

Mela

nie

Sw

an

Researc

h A

ssocia

te

MS

Futu

res G

roup

415-5

05-4

426

m@

mela

nie

sw

an.c

om

ww

w.m

ela

nie

sw

an.c

om

CO

NT

AC

T 2

009

April 3,

200

9

Slid

es: http

://s

lideshare

.net/

LaB

logga/s

lideshow

s

1C

ON

TA

CT

2009

Apri

l 3, 2009

Agenda

1.

Intr

oduction:

converg

ence o

f lif

e a

nd t

echn

olo

gy

2.

Sta

tus o

f re

levant

hig

h-im

pact

researc

h

3.

Futu

re im

plic

ations

2C

ON

TA

CT

2009

Apri

l 3, 2009

Source: http://www.kurzweilai.net/pps/Unither

Full

hum

an b

rain

neura

l sim

ula

tio

n e

st: 2

018

Ave

rage

hu

man

: an

estim

ate

d 2

0,0

00

trilli

on

IP

S

an

d 1

,00

0 T

B m

em

ory

2

IBM

Ro

ad

run

ne

r: 1

pe

taflop

/s(>

1,0

00

trilli

on

IPS

) an

d 8

0 T

B m

em

ory

1

1http://www.top500.org/lists/2008/11, http://www.top500.org/system/8968

2http://paula.univ.gda.pl/~dokgrk/bre01.html

3C

ON

TA

CT

2009

Apri

l 3, 2009

Engin

eering life into

technolo

gy

2029

Machin

e

Hum

an

Hum

an′?

Capabili

ty

Year

Inte

llig

ence

converg

en

ce:

Life a

nd T

echno

logy

4C

ON

TA

CT

2009

Apri

l 3, 2009

Agenda

1.

Intr

oduction:

converg

ence o

f lif

e a

nd t

echn

olo

gy

2.

Sta

tus o

f re

levant

hig

h-im

pact

researc

h

�E

volv

ing c

oncept of lif

e s

cie

nces

�G

enom

ic e

ra

�S

ynth

etic b

iolo

gy

�N

anom

edic

ine

�In

telli

gence r

esearc

h

�Longevity

3.

Futu

re im

plic

ations

5C

ON

TA

CT

2009

Apri

l 3, 2009

Evolv

ing c

oncept of lif

e s

cie

nces

Model and

sim

ulate

Enumerate

and

experiment

Build

Bio

Spic

e.o

rg

Sim

TK

.org

Pa

rtsR

egis

try.o

rg

6C

ON

TA

CT

2009

Apri

l 3, 2009

Cu

re

Imp

rove

men

t

No

rma

liza

tion

Pre

ve

ntion

Enhan

cem

en

t

Se

lf-

exp

ressio

n

Cond

itio

ns

Sym

pto

ms

Ge

nom

eB

iom

ark

ers

Beha

vio

rE

nviron

men

t

Health

outcomes

Measure

Re

sea

rch

Tre

at

Inte

rven

e

Exp

erim

en

t

Tra

ck

Me

asu

re

ActionsSe

lf

Pro

fessio

na

ls

Pee

rs

Evolv

ing d

efinitio

n o

f health

Source: http://www.mdpi.com/1660-4601/6/2/492

A n

ew

mod

el of

health

and h

ea

lth

care

7C

ON

TA

CT

2009

Apri

l 3, 2009

Evolv

ing c

om

puting m

odels

Curr

ent

mode

l exte

nsib

ility

Lin

ear,

von

Neum

ann

Lin

ear,

von

Neum

ann

Para

llel

Para

llel

Clo

ud, grid,

dis

trib

ute

d

Clo

ud, grid,

dis

trib

ute

dB

iolo

gic

al m

ode

ls

Novel m

od

els

Tra

ditio

nal m

ode

l

Quantu

mQ

uantu

mO

ptical

com

puting

Optical

com

puting

Cell

bro

adband

engin

e

Cell

bro

adband

engin

eLiq

uid

com

pute

r

Liq

uid

com

pute

r

New

mate

rials

New

mate

rials

3D

chip

sta

ckin

g

3D

chip

sta

ckin

g

Mole

cula

r

ele

ctr

onic

s

Mole

cula

r

ele

ctr

onic

sS

ola

r

transis

tors

Sola

r

transis

tors

DN

A n

anote

ch

DN

A n

anote

ch

DN

A

com

puting

DN

A

com

puting

Bio

sensors

Bio

sensors

Cellu

lar

colo

nie

s

Cellu

lar

colo

nie

s

Bacte

rial

inte

lligence

Bacte

rial

inte

lligence

Bio

para

dig

m

dis

covery

Bio

para

dig

m

dis

covery

8C

ON

TA

CT

2009

Apri

l 3, 2009

Genom

ic e

ra C

arlson c

urv

es: 12 m

o s

peedups

�S

eq

ue

ncin

g

�(r

eadin

g)

�S

ynth

esiz

ing

�(w

riting)

Source: http://www.synthesis.cc/graphics/carlson_cost_per_base_nov_08.jpg

9C

ON

TA

CT

2009

Apri

l 3, 2009

Direct-

to-c

onsum

er

genom

ics: 23andm

e

580,000 SNPs scanned and mapped to 78 conditions

Source: http://www.23andme.com; open source genomes http://www.snpedia.com/index.php/Genomes

10

CO

NT

AC

T 2

009

Apri

l 3, 2009

23andm

e c

olo

recta

l cancer

mark

er

Source: http://www.23andme.com

11

CO

NT

AC

T 2

009

Apri

l 3, 2009

Next-

gen s

equencin

g: P

acific

Bio

scie

nces

Sources: http://www.pacificbiosciences.com/video_lg.html,

http://www.sciencemag.org/cgi/content/abstract/323/5910/133,

Science 2 January 2009: Vol. 323. no. 5910, pp. 133 –138, DOI: 10.1126/science.1162986

Pho

sph

olin

ked

nu

cle

otide

s

DN

A p

oly

me

rase

wra

ppe

d a

round

DN

A c

ha

in

Pho

sph

olin

ked

nu

cle

otide

bin

ds, flu

ore

sce

s

an

d d

eta

che

s a

s n

ucle

otid

e b

ase

is r

ead

1 2

3a

3b

12

CO

NT

AC

T 2

009

Apri

l 3, 2009

Next-

gen b

iote

ch: synth

etic b

iolo

gy

�E

ng

ineeri

ng b

iolo

gic

al

syste

ms

�P

art

s R

egis

try

�B

ioB

ricks F

oundation

�iG

EM

com

petition

�K

ey w

ork

: D

rew

Endy,

Jay K

easlin

g,

Cra

ig

Vente

r, C

hristin

a S

molk

e,

Tom

Knig

ht

Sources: http://openwetware.org, http://bbf.openwetware.org,

http://www.igem.org, http://partsregistry.org

13

CO

NT

AC

T 2

009

Apri

l 3, 2009

Regis

try o

f S

tandard

Bio

logic

al P

art

s

Source: http://partsregistry.org

�M

odula

r build

ing b

lock c

om

ponents

14

CO

NT

AC

T 2

009

Apri

l 3, 2009

Part

s R

egis

try: sele

ct m

easure

ment syste

m

Source: http://partsregistry.org

15

CO

NT

AC

T 2

009

Apri

l 3, 2009

Part

s R

egis

try: obta

in a

nd p

rint sequence

DN

A S

ynth

esiz

er

Source: http://partsregistry.org

16

CO

NT

AC

T 2

009

Apri

l 3, 2009

Nanom

edic

ine

�N

ano

part

icle

s

�D

NA

nan

ote

chn

olo

gy

�D

NA

walk

er

�P

rogra

mm

ab

le m

att

er

�Q

uantu

m d

ots

�N

anom

ach

ines

Re

sp

iro

cyte

sM

icro

biv

ore

Art

ery

cle

ane

r

Nano

pa

rtic

les

Sources: Nanoparticles: http://www.unithertechnologyconference.com

DNA Nanotechnology: http://www.pnas.org/content/101/3/717.full.pdf

Nanorobots: http://www.foresight.org/Nanomedicine/gallery/index.html#ExhibitCat

Va

scu

locyte

Clo

tto

cyte

s

DN

A w

alk

er

Str

uctu

ral D

NA

:

Ho

llida

y ju

nction

Qu

an

tum

do

t d

ye

s

17

CO

NT

AC

T 2

009

Apri

l 3, 2009

Radio

surg

ery

and o

n-d

em

and p

hysic

ians

Te

lera

dio

logy

da

Vin

ci R

obo

tic S

urg

ery

OR

-Liv

e.c

om

On

-dem

and

co

nsu

lta

tion

: A

me

rican

Well

Accu

ray r

ad

iosu

rge

ry d

eliv

ery

pa

th

Accu

ray c

yb

erk

nife

ra

dio

su

rge

ry

18

CO

NT

AC

T 2

009

Apri

l 3, 2009

Sim

ula

tion, m

odelin

g a

nd v

irtu

al health

En

telo

s v

irtu

al p

atien

t b

iosim

ula

tion

Te

stis tou

r: O

SU

Med

icin

e

Sources: http://biospice.org, http://www.youtube.com/watch?v=O1YuRSyzBAE,

secondlife://PalomarW

est%

20Hospital/36/125/34/, secondlife://NHS%20London/248/11/26

Se

cond

Hea

lth

Ope

ratin

g T

he

atr

e

Bio

SP

ICE

ope

n s

ou

rce s

imula

tion

soft

wa

re

Virtu

al ho

sp

ita

l: P

alo

ma

r W

est

19

CO

NT

AC

T 2

009

Apri

l 3, 2009

Inte

llige

nce r

esearc

h b

y a

ppro

ach

�C

om

pute

r sim

ula

tion

�C

ort

ical colu

mn s

imula

tion

�W

hole

bra

in e

mula

tion

�N

euro

imag

ing

& c

onn

ecto

mic

s

�K

ES

M tis

sue v

olu

mes

�In

tegra

tion

�B

rain

-com

pute

r in

terf

aces (

BC

Is)

�B

ody a

rea n

etw

ork

s (

BA

Ns)

�IE

EE

sta

ndard

802.1

5.6

�R

obotics a

nd A

I

Blu

e B

rain

ra

t co

rtic

al co

lum

n

Mo

use

bra

in b

lock a

nd c

ort

ex s

lice

Sources: http://seedmagazine.com/content/article/out_of_the_blue,

http://www.mcb.harvard.edu/lichtman/ATLUM/ATLUM_web.htm,

http://research.cs.tamu.edu/bnl/kesm.html

Ve

sic

le

20

CO

NT

AC

T 2

009

Apri

l 3, 2009

Longevity: exte

ndin

g life

span a

nd h

ealthspan

�A

gin

g a

s a

multid

iscip

linary

path

olo

gy

�A

ubre

y d

e G

rey: S

trate

gie

s for

Engin

eere

d

Neglig

ible

Senescence (

SE

NS

)

�N

ucle

ic a

nd m

itochondri

al m

uta

tions

�In

tracellu

lar

an

d e

xtr

acellu

lar

junk

�C

ell

loss a

nd s

enesce

nce

�E

xtr

ace

llula

r cro

sslin

ks

�S

olu

tions a

nd e

scape v

elo

city

�B

iom

ed

ical re

media

tion

�M

uta

tion a

nti-s

uppre

ssors

�C

ell

str

en

gth

en

ing

�R

ealA

ge.c

om

estim

ation tests

0

10

20

30

40

50

60

70

80

90

1850

1900

1950

2000

2050

U.S. Life Expectancy, 1850 –2050e

83

77

69

50

39

Source: http://www.infoplease.com/ipa/A0005140.html

Source: http://earthtrends.wri.org/text/population-health/variable-379.html

Sources: http://www.mfoundation.org/index.php?pagename=mj_sens_sens,

http://pimm.wordpress.com/2007/09/03/sens3-program-john-schloendorn-m

edical-bioremediation,

http://www.mfoundation.org/files/sens/manu16.pdf, http://www.lmrf.org/LysoSENS.html

Lyso

SE

NS

: sta

ined

lyso

so

me

s

21

CO

NT

AC

T 2

009

Apri

l 3, 2009

Agenda

1.

Intr

oduction:

converg

ence o

f lif

e a

nd t

echn

olo

gy

2.

Sta

tus o

f re

levant

hig

h-im

pact

researc

h

3.

Futu

re im

plic

ations

22

CO

NT

AC

T 2

009

Apri

l 3, 2009

Engin

eering life into

technolo

gy

2029

Machin

e

Hum

an

Hum

an′?

Capabili

ty

Year

Co

nverg

en

ce:

Life a

nd T

echno

logy

�E

volv

ing c

oncept of lif

e

scie

nces

�G

enom

ic e

ra

�S

yn

thetic b

iolo

gy

�N

anom

edic

ine

�In

telli

gence

�Longevity

Foundations of Convergence

23

CO

NT

AC

T 2

009

Apri

l 3, 2009

What can b

e e

xpecte

d in the s

hort

-term

?

Image: Natasha Vita-M

ore, Primo Posthuman

�O

nboard

com

puta

tio

n a

nd

com

munic

ation

�W

hole

hum

an g

en

om

e s

can

�E

ra o

f pers

onaliz

ed m

edic

ine

�N

ext-

gen

bio

tech,

the n

ew

cle

ante

ch

�F

ocus o

n k

ey c

ure

s: obesity, cancer

�P

eer-

to-p

eer

health

�H

ealth s

ocia

l netw

ork

s

�Long tail

of m

edic

ine

�C

ulture

of bio

hackin

g

24

CO

NT

AC

T 2

009

Apri

l 3, 2009

Ultim

ate

possib

ilities for

life a

nd technolo

gy

�A

ll m

att

er

(inclu

din

g life)

desig

ne

d t

o s

pec

�P

urp

ose-d

riven form

facto

r, e

lective e

mbodim

ent

�Is

sues

�M

ultip

le p

ers

iste

nt copie

s

�T

ranshum

anis

m, posth

um

anis

m

�U

tilit

y functions a

nd e

motion

�In

telli

gence

�U

ltim

ate

possib

ilities for

life a

nd

technolo

gy o

nce join

ed?

�A

esth

etics?

�A

naly

tics?

25

CO

NT

AC

T 2

009

Apri

l 3, 2009

Resourc

es

�C

onfe

rences,

podcasts

and v

ideo

�http:/

/ww

w.u

nithe

rtechnolo

gyconfe

rence.c

om

�http:/

/ww

w.u

sc.e

du/m

edic

ine/b

cc

�http:/

/ww

w.c

s.d

uke.e

du/~

reif/F

NA

NO

�http:/

/ww

w.o

ne

medpla

ce.c

om

�http:/

/ww

w.o

r-liv

e.c

om

�Journ

als

, ne

ws,

blo

gs,

advoca

cy g

roups,

etc

.

�http:/

/ww

w.n

atu

re.c

om

/nbt/

index.h

tml

�http:/

/ww

w.n

btc

.corn

ell.

edu

�http:/

/ww

w.e

yeon

DN

A.c

om

�http:/

/ph

ylo

geno

mic

s.b

logspot.com

�http:/

/ww

w.p

ers

onaliz

edm

edic

inecoalit

ion.o

rg

�E

thic

s a

nd b

iote

chno

log

y indu

str

y w

atc

h g

rou

ps

�http:/

/ww

w.b

ioeth

ics.n

et

(Am

erican J

ourn

al of B

ioeth

ics)

�http:/

/ww

w.e

tcgro

up.o

rg

Thank y

ou

Mela

nie

Sw

an

Researc

h A

ssocia

te

MS

Futu

res G

roup

415-5

05-4

426

m@

me

lan

iesw

an

.com

ww

w.m

ela

nie

sw

an

.com

Slid

es: http://s

lideshare

.net/LaB

logga/s

lideshow

s

Cre

ative

Com

mon

s 3

.0 lic

en

se