Coenzyme Q10 (also known as CoQ10 and ubiquinone) is a fat-soluble antioxidant. Often described as being vitamin-like, CoQ10 is actually a co-factor (it can’t be called a vitamin because the body can make it), a substance that’s needed by the body for certain enzymes to function at their best. It is responsible for producing 95 per cent of your cells’ energy and is found in highest concentrations in the inner membrane of the mitochondria. Cells with the highest energy demands, such as in the heart and liver, have the highest levels of CoQ10. A number of human clinical trials have shown CoQ10’s effectiveness in maintaining healthy heart function.CoQ10 is made in the liver from the amino acid, tyrosine plus vitamin C, and B vitamins including folic acid.

Part of your CoQ10 comes via foods such as liver, kidney,

whole grains, oily fish including tuna, peanuts, walnuts, chicken, canola and soybean oils.

It is CoQ10’s job to help generate the kind of energy that the body can use. In other words, coenzyme Q10 helps to convert food energy into cellular energy.

What happens in deficiency?Deficiency of CoQ10 is seen in some medical conditions – but whether deficiency is a cause of the disease or a side effect of it, is still being researched.

Taking a supplement of CoQ10 can correct deficiency – whether this is due to illness or due to age. It works by helping to feed cells that are starved of energy and exhausted. More studies are continuing to examine the effects of CoQ10 on survival after a major condition.

CoQuinone 100TM

Fuel your cellular engines!

• If you want to help speed recovery after exercise (CoQ10 levels decline with exercise). In athletes, CoQ10 may:

- reduce muscle fatigue - speed up recovery times

- improve athletic performance Studies show greater improvement in both anaerobic and aerobic exercise with CoQ10 supplementation.

• If you want to inhibit the oxidation of LDL-cholesterol, the harmful type of choldesterol associated with raised risk of heart and blood vessel problems.

• If you want to enhance your heart health CoQ10 might help.

So how does

CoQ10 work?

COULD YOU DO WITH A COQ10 BOOST?

Enhancing energy releaseCoQ10 is needed for the production of energy in the mitochondria of the cells. This is where the chemical reactions that release energy from glucose (respiration) happen and adenosine triphosphate (ATP) is produced – this is the form of energy that cells use to function. ATP provides energy needed to run other processes in the body. When ATP breaks down, the energy created is used by cells for processes such as active transport, DNA replication and muscle contraction.

Antioxidant actionCoQ10 helps to protect body tissues against damage from toxic molecules known as free radicals. Free radicals are produced as a by-product of energy production in the mitochondria. CoQ10 assists in ATP production and works with other antioxidants to remove free radicals protecting cells from their damaging effects. As an antioxidant, it rivals vitamins E and C. In addition, CoQ10 helps to regenerate and recycle vitamin E. CoQ10 is the only lipid-soluble antioxidant that is synthesised in your body.

Lipoprotein protector CoQ10 protects low density lipoproteins from oxidation. Cholesterol is very prone to free radical damage and this can lead to the formation of a toxic derivative called oxidized LDL-cholesterol. It is thought that LDL-cholesterol is harmful to the body after becoming oxidized. CoQ10 inhibits the oxidation of LDL-cholesterol.

Energy enhancer Tissues and organs that need a lot of energy have large numbers of mitochondria in their cells, for example, the heart, liver and muscle cells. And, getting enough CoQ10 is especially important to power these high energy cells. Without CoQ10, the cells gradually lose power. Over time, continued low levels of cellular energy can have a negative health impact – a bit like a car running out of fuel.especially at risk of bone fractures. Hormonal changes affect bone strength plus women tend to have a smaller skeleton and less calcium compared with men to begin with. About half of all women over the age of 60 years will have at least one fracture due to osteoporosis. But osteoporosis affects men, too – 23 per cent of men have the condition.

It benefits muscles which have a high energy turnover which therefore have high energy needs. Large studies have shown that supplementing with CoQ10 can improve heart health and quality of life without side effects.

• If you’re taking certain medications which block the production of cholesterol in the liver. These also interfere with the production of CoQ10. Getting enough CoQ10 may help to promote healthy muscle function, boosting the body’s immune system and may even offer relief from migraines.

• If you are over 65 years. Your ability to produce CoQ10 decreases with age.

According to the University of Maryland Medical Center, the daily recommended supplement dose for CoQ10 in adults is 30 to 200mg. The UK not-for-profit organisation Action for ME says higher doses may be recommended for people with certain medical conditions, including chronic fatigue syndrome (CFS/ME).

To help maintain healthy levels of CoQ10, take one

CoQuinone 100™ – you’ll find similar amounts in a kilo of

beef, half a kilo of sardines or a kilo of peanuts.

CoQuinone 100™ Health basics

CoQuinone 100™ are a great way to ensure you keep your levels topped up. If you are older and/or you take certain medications (please talk to your doctor). USANA’s CoQuinone contains 30mg of CoQ10 and 12.5mg of alpha lipoic acid per soft gel capsule.

Alpha lipoic acidUSANA’s CoQuinone products contain alpha lipoic acid, a powerful antioxidant that plays a crucial role in helping to support superior cellular energy production. Alpha lipoic acid is both fat and water-soluble. This powerful antioxidant attacks waste products created when the body turns food into energy. It also helps to recycle other antioxidants so that they become active again which helps to fight the chemicals that threaten to damage your cells.

1kgbeef 500g

sardines1kg

peanuts

Speaking at the Heart Failure 2013 Congress, Professor Svend Aage Mortensen, Fellow of the European Society of

Cardiology, researcher at the Heart Centre at the University Hospital, Copenhagen, Denmark said:

‘CoQ10 is the first medication to improve survival in chronic

heart failure since ACE inhibitors and beta blockers more than a decade ago and

should be added to standard heart failure therapy. ’

The Q-SYMBIO study randomised 420 patients with severe heart failure (New York Heart Association (NYHA) Class III or IV) to CoQ10 or placebo. Patients were followed for two years. Participating centres were in Denmark, Sweden, Austria, Slovakia, Poland, Hungary, India, Malaysia and Australia.

Results showed that taking CoQ10 halved the risk of major adverse cardiovascular event (MACE). CoQ10 also halved the risk of dying from all causes, which occurred in 18 (nine per cent) of patients in the CoQ10 group compared to 36 (17 per cent) of patients in the placebo group.

CoQ10-treated patients had significantly lower cardiovascular mortality and fewer hospitalisations for heart failure. There were fewer adverse events in the CoQ10 group compared to the placebo group too.

References Levy HB, Kohlhaas HK. Considerations for supplementing

with coenzyme Q10 during statin therapy. Ann Pharmacother. 2006 Feb;40(2):290-4. Epub 2006 Jan 31. Accessed 1

August 2013. Available from: http://www.ncbi.nlm.nih.gov/pubmed/16449543?dopt=Abstract

Coenzyme Q10. University of Maryland Medical Center. Accessed 1 August 2013. Available from: http://umm.edu/health/

medical/altmed/supplement/coenzyme-q10

SA Mortensen, A Kumar, P Dolliner, et al. The effect of coenzyme Q10 on morbidity and mortality in chronic heart

failure. Results from the Q-SYMBIO study. Presented at Heart Failure Congress 2013 Final Programme Number 440. Accessed

1 August 2013. Available from: http://www.escardio.org/about/press/press-releases/pr-13/Pages/first-drug-in-decade-

improves-heart-failure-mortality.aspx

European Society of Cardiology. A potential new approach to improve heart failure outcome

Coenzyme Q10 decreases all-cause mortality by half in randomised double blind trial 25 May 2013. Accessed 1 August

2013. Available from: http://www.escardio.org/about/press/press-releases/pr-13/Pages/first-drug-in-decade-improves-

heart-failure-mortality.aspx

Rev 01/16. Content approved for Australia and New Zealand.

Vitamin supplements should not replace a balanced diet. Always read the labels. Use only as directed.

For more information about the USANA products and business opportunity, contact your independent USANA Associate using the contact details below.

USANA Australia Pty Ltd 3 Hudson Avenue,Castle Hill, NSW 2154, Australia

USANA Health Sciences (NZ) Corporation Level 1, 93 Ascot Avenue, Greenlane,Auckland 1051, New Zealand

USANA Customer Service Phone: (61-2) 9842 4600 Toll Free: 1800 OUR USANA (1800 687 872) - AU

0800 USANA NZ (0800 872 626) - NZ

www.usana.com

Boosted bioavailabilityUSANA’s CoQuinone 100 delivers cellular nutrients mixed with medium chain triglycerides, glycerin, and lecithin oils that help to boost absorption for unbeatable bioavailability. The proprietary USANA CoQuinone 100 formula is clinically proven to deliver more CoQ10 to the bloodstream than competing products. Absorption will be even better if you take CoQuinone 100 with food that contains some healthy fat.

• An optimal combination of Coenzyme Q10 and alpha lipoic acid

• Central to robust energy production within the cell

• Provides ingredients vital for cardiovascular health

• Contains a powerful blend of antioxidants

Clinical tests performed in USANA’s laboratories show that USANA CoQuinone 100 delivers CoQ10 in much higher quantities than solid formulations or from competitive liquid formulations, making USANA CoQuinone 100 more bioavailable than other CoQ10 products.

Take one CoQuinone 100 capsules daily, preferably with meals.

1. Cuomo J, Rabovsky A, Clinical Research Bulletin, USANA Health Sciences, 2000. http://www.usana.com/bin/5CRB.pdf

USANA’s CoQuinone™ uses a proprietary formulation that delivers substantially more CoQ10 to the blood plasma than other competing dosage forms.1

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