Frequency of COP cells in control mice (caALK2)

#1 #2 #3 #4 Average (%)

Baseline(WT)

undetectable 0.34 0.17

Baseline(caALK2)

0.25 0.25

Day 2 0.21 0.20 0.21

Day 7 0.92 0.40 0.84 0.52 0.67

Day 14 0.44 0.36 0.27 0.48 0.38

Control mice: received Ade-Cre and cardiotoxin but no treatment

Baseline: no injection

0

0.1

0.2

0.3

0.4

0.5

0.6

0.7

baseline day 2 day 7 day 14

COP cells

COP cells in patients with fractures

• Objective - to measure the frequency of COP cells in

patients with fracture(s) - COP cells in acute fracture phase (within 7

days after the fracture) vs. in stable phase (in 12 weeks after the fracture)

- longitudinal comparison within subjects

COP cells in fracture patient #1

71 yo female, samples obtained on day 1 after right femoral fracture, no significant co-morbidity

COP cells in fracture patient #2

51 yo male, samples obtained on day 2 after left humeral fracture