Petra van Wetten, Principal ProgrammerPhUSE – annual conference 2014

Forest Plot: W3 + H2

What is it, Why use it, When to use it+ How to generate and How to interpret

Forest Plot: W3 + H2 - What, Why, When and How

| PhUSE 2014 | Petra van Wetten | 14/10/2014 | Forest Plots | Business Use Only2

How do we interpret?

How do we generate it?

| PhUSE 2014 | Petra van Wetten | 14/10/2014 | Forest Plots | Business Use Only3

What is a Forest Plot?

Why do we use it?

When do we use it?

Forest Plot: W3 + H2 - What, Why, When and HowContext

Subgroup analysis of change from baseline in <parameter> at month x

• Meta-Analysis• Subgroup Analysis• Sensitivity Analysis Stay cool

and

be a

PROGRAMMER

Forest Plot: W3 + H2 - What, Why, When and How

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Meta-Analysis - How to interpret

Forest Plot: W3 + H2 - What, Why, When and How

| PhUSE 2014 | Petra van Wetten | 14/10/2014 | Forest Plots | Business Use Only5

Subgroup Analysis - How to interpret

Forest Plot: W3 + H2 - What, Why, When and How

| PhUSE 2014 | Petra van Wetten | 14/10/2014 | Forest Plots | Business Use Only6

How to generate - Proc Template

Forest Plot: W3 + H2 - What, Why, When and How

| PhUSE 2014 | Petra van Wetten | 14/10/2014 | Forest Plots | Business Use Only7

How to generate – ODS Graphics Designer

Forest Plot: W3 + H2 - What, Why, When and How

| PhUSE 2014 | Petra van Wetten | 14/10/2014 | Forest Plots | Business Use Only8

Proc template versus ODS graphics designer

Proc Template ODS Graphics Designer

Well prepared input dataset required

Advanced programming skills required Drag & Drop toolNot as easy to set up as expected

High quality graphs Preferable for simple graphsCode needs to be modified for more sophisticated outputs

Re-usable template Code can be retrieved and saved as template to be reused

Forest Plot: W3 + H2 - What, Why, When and How

| PhUSE 2014 | Petra van Wetten | 14/10/2014 | Forest Plots | Business Use Only9

Acknowledgments and References

� Acknowledgments:• Jimmy Fernandes• Harry Staines• James Gallagher• All other supportive colleagues

� References:• http://www.ema.europa.eu/docs/en_GB/document_library/Scientific_guideline/2014/02/WC500160523.pdf • Meta-Analysis of cardiovascular outcomes trials, Comparing intensive versus moderate statin therapy Christopher P. Cannon, Benjamin A. Steinberg, Sabina A. Murphy, Jessica L. Mega, Eugene Braunwald

• Michael Borenstein, www.Meta-Analysis.com, lecturing session on YouTube https://www.youtube.com/watch?v=xWiXeKR3dB4)

• Creating Forest Plots from Pre-computed Data using PROC SGPLOT and Graph Template Language • SAS/GRAPH(R) 9.2: ODS Graphics Designer Help: support.sas.com/documentation/cdl/en/grstatdesign/61690/HTML/default/viewer.htm#p0swzt49p7k30rn1jnztg97nuicp.htm)

Forest Plot: W3 + H2 - What, Why, When and How

| PhUSE 2014 | Petra van Wetten | 14/10/2014 | Forest Plots | Business Use Only10

Conclusion

Forest Plot: W3 + H2 - What, Why, When and How

| PhUSE 2014 | Petra van Wetten | 14/10/2014 | Forest Plots | Business Use Only11