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Controlled Substances Act
• Federal Law established 5 schedules of classification of controlled substances based on– Drug’s potential for abuse– Potential to physical and
psychological dependence– Medical Value
• Also controls materials that used in making drugs and those that are manufactured to resemble drugs
Drug Schedules
• Schedule I: • Drugs with high potential for abuse and
addiction, NO medical value
Ex:• Schedule II: • Drugs with high potential for abuse and
addiction, have some medical value with restrictions
Ex:
Drug Schedules
• Schedule III: • Drugs with less potential for abuse and
addiction, currently acceptable for medical useEx:
• Schedule IV: • Drugs with low potential for abuse and
addiction, currently acceptable for medical useEx:
Drug Schedules
• Schedule V:
• Drugs with low potential abuse, medical use, lowest potential dependency
• Ex:
Role of the Toxicologist• Must identify one of thousands of
drugs and poisons• Must find milligram to gram
quantities dissipated throughout the entire body
• Not always looking for exact chemicals, but metabolites of desired chemicals (ex. heroin morphine within seconds)
Toxicology Procedures
• 10mL of– Add– Add
• 2 consecutive– Some drugs take a while to show up
(1-3 days)
Color Tests
• Marquis Test: – Turns purple in the presence of Heroin,
morphine, opium – Turns orange-brown in presence of
Amphetamines
• Scott Test: Three solutions
– Blue then pink then back to blue in the presence of Cocaine
• Duquenois-Levine: – Test for marijuana –turns purple
More Analytical Tests
• Microcrystalline Tests: Identifies drug by using chemicals that reacts to produce characteristic crystals
• Chromatography: TLC, HPLC and gas – separate drugs/tentative ID
• Mass Spectrometry: chemical “fingerprint” no two drugs fragment the same
Why?
• Think of all the people that you have “heard” do drugs.
• US drug manufacturers produce enough barbiturates and tranquilizers each year to give every person in the US 40 pills
• (that’s about 12 billion pills)• 18,000 out of 44,000 annual traffic deaths
are alcohol related and send over 2 million people to the hospital
Toxicology of Alcohol
• Alcohol is absorbed through the stomach and intestine
• Once absorbed, alcohol is:
Toxicology of Alcohol
• Alcohol 1st affects the forebrain and moves backward
• Last affected is medulla oblongata
Field Sobriety Tests
• Horizontal Gaze Nystagmus– Involuntary eye jerk when moving horizontally
• Walk and Turn• One-Leg Stand
The Breathalyzer
• Invented in 1954 by an Indiana state trooper
• Spectrophotometer designed to measure the absorption of light passing through potassium dichromate
The Breathalyzer
• 2K2Cr2O7 + 3C2H5OH + 8H2SO4 2Cr2(SO4)3 + 2K2SO4 + 3CH3COOH + 11H2O
• Indirectly measures alcohol quantity by measuring amount of potassium dichromate
Potassium dichromate
Ethyl alcohol
Sulfuric acid
Chromium sulfate
Potassium sulfate
Acetic acid
Dihydrogen oxide
Infrared and Fuel Cell Breath Tests• Infrared Breath Test
uses infrared wavelengths to test for acetone or other interferences in the breath
• Fuel Cell Test converts fuel (alcohol) and oxygen into a measurable electric current
Alcohol and the Law
• Try the drink wheel: http://www.intox.com/wheel/drinkwheel.asp