Flow diagram of the systematic literature search indicating the inclusion and exclusion process of studies

Liakopoulos OJ, et al. Eur Heart J 2008;29:1548-59

Characteristics of included studies (n = 19) – Part I

Liakopoulos OJ, et al. Eur Heart J 2008;29:1548-59

Characteristics of included studies (n = 19) – Part II

Liakopoulos OJ, et al. Eur Heart J 2008;29:1548-59

Forest plot of retrieved studies evaluating preoperative statin use and the incidence of early all-cause mortality after

cardiac surgery. OR, odds ratio; CI, 95% confidence interval

Liakopoulos OJ, et al. Eur Heart J 2008;29:1548-59

Incidence of clinical outcomes

Liakopoulos OJ, et al. Eur Heart J 2008;29:1548-59

Forest plot of retrieved studies evaluating preoperative statin use and the incidence of myocardial infarction after cardiac

surgery. OR, odds ratio; CI, 95% confidence interval

Liakopoulos OJ, et al. Eur Heart J 2008;29:1548-59

Forest plot of retrieved studies evaluating preoperative statin use and the incidence of atrial fibrillation after cardiac surgery. OR, odds ratio; CI, 95% confidence interval

Liakopoulos OJ, et al. Eur Heart J 2008;29:1548-59

Forest plot of retrieved studies evaluating preoperative statin use and the incidence of stroke after cardiac surgery

OR, odds ratio; CI, 95% confidence interval

Liakopoulos OJ, et al. Eur Heart J 2008;29:1548-59

Forest plot of retrieved studies evaluating preoperative statin use on the incidence of renal failure after cardiac surgery

OR, odds ratio; CI, 95% confidence interval

Liakopoulos OJ, et al. Eur Heart J 2008;29:1548-59

Preoperative characteristics of patients

Liakopoulos OJ, et al. Eur Heart J 2008;29:1548-59

Funnel plot with solid circles representing actual included studies with their respective study weight (%). The Trim-and-Fill method suggested that only one missing study was needed to achieve a symmetrical funnel plot, as indicated by the open circle. The solid vertical line represents the unadjusted odds ratio (OR) for short-term mortality, and the dotted line indicates the recalculated adjusted

OR after allowing for publication bias. SE, standard error.

Liakopoulos OJ, et al. Eur Heart J 2008;29:1548-59