Flow Diagram of the Main HOPE Trial and the HOPE-TOO Trial Extension

The HOPE and HOPE-TOO Trial Investigators JAMA. 2005;293:1338-1347

Baseline Characteristics

of All HOPE Study Patients

and of the Patients at

Centers Continuing in

the Trial Extension

(HOPE-TOO)

The HOPE and HOPE-TOO Trial Investigators JAMA. 2005;293:1338-1347

Incidence and Relative Risks of Cancers and Deaths Due to Cancer

The HOPE and HOPE-TOO Trial Investigators JAMA. 2005;293:1338-1347

Kaplan-Meier Analysis of the Effects of Vitamin E on Incident Cancer and

Major Cardiovascular Events for All 9541 Study Patients

The HOPE and HOPE-TOO Trial Investigators JAMA. 2005;293:1338-1347

Incidence and Relative Risks of Site-Specific Cancers

The HOPE and HOPE-TOO Trial Investigators JAMA. 2005;293:1338-1347

Incidence and Relative Risks of Major Vascular Events, Deaths, and Secondary

Cardiovascular Outcomes

The HOPE and HOPE-TOO Trial Investigators JAMA. 2005;293:1338-1347

Kaplan-Meier Analysis of the Effects of Vitamin E

on All Heart Failure Events and Hospital Admissions

for Heart Failure in HOPE and HOPE-TOO Patients

The HOPE and HOPE-TOO Trial Investigators JAMA. 2005;293:1338-1347

Lung Cancer in Large Randomized Trials of Vitamin E

The HOPE and HOPE-TOO Trial Investigators JAMA. 2005;293:1338-1347