First world conference onluteinizing hormone in assistedreproductive technology27-28 May 2016 - Naples, Italy

INTERNATIONAL CONFERENCEPRELIMINARY PROGRAMME

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OverviewThe role of luteinizing hormone (LH) during folliculogenesis hasheightened curiosity for at least three decades. In particular, thescientific community is still divided over recognizing the relevance ofLH containing drugs during controlled ovarian stimulation (COS).Availability of recombinant drugs has offered, for the first time, theopportunity to explore the role of the follicle stimulating hormone(FSH) and luteinizing hormone (LH) separately. Despite thisopportunity, the role of recombinant LH is still a matter of debate.What recently emerged is that LH is actively able to improve theoutcome of IVF in specific subgroup of patients, including advancedage women (>35 years old) and the so-called “hypo-responders”. Thelatter group is represented by subjects that, despite being young,having normal ovarian reserve, and being classified asnomonadotrophic, show “slow” and sub-optimal response toconventional FSH doses. It was estimated that the profile of ovarianresponse is evident in 10-12% of women undergoing COS. Moreinterestingly, the increase in ongoing pregnancy rates in these twosubgroups of women does not seem to be correlated with the numberof oocytes, suggesting that improvement in oocyte quality and/orextragonadal effects of LH could be implicated. Although a growingbody of evidence is defining the role of LH during COS, clear guidelinesand practical recommendations on this aspect are lacking.

This conference will show evidence from basic science to clinicalpractice regarding the use of recombinant LH and will illustrate itspossible benefits as well as its physiopathological mechanism. Guidedby an expert, participants will grasp the rationale for usingrecombinant LH in assisted reproductive technology as well asunderstand the role of LH in human reproduction.

Learning objectivesBy attending this live educational conference, participants will be able to:• Understand the physiology of LH and its role in ovulation induction• Grasp the state of the art regarding the use of recombinant LH use • Individualise groups of patients that required LH duringstimulation protocols

• Identify specific ovarian reserve markers and genotypepolymorphism useful for tailoring treatments and choosing thebest approach

Target audienceThis programme is intended for clinicians, embryologists, biologistsand scientists working in ART.

Honorary PresidentGiuseppe De PlacidoUniversity of Naples " Federico II" NaplesNaples, Italy

ChairsCarlo AlviggiUniversity of Naples " Federico II" NaplesNaples, Italy

Sandro C. EstevesANDROFERT - Andrology & Human Reproduction Clinic São Paulo, Brazil

Local scientific committee

Coordinator

Ida StrinaUniversity of Naples " Federico II" NaplesNaples, Italy

Luisa AvinoUniversity of Naples " Federico II" NaplesNaples, Italy

Alessandro ConfortiUniversity of Naples " Federico II" NaplesNaples, Italy

Pasquale De RosaUniversity of Naples " Federico II" NaplesNaples, Italy

Silvia PicarelliUniversity of Naples " Federico II" NaplesNaples, Italy

Roberta ValloneUniversity of Naples " Federico II" NaplesNaples, Italy

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CME ProviderEXCEMED is a non profit foundation dedicated, since the last fourdecades, to the development of high-quality medical educationprogramme all over the world.

EXCEMED adheres to the guidelines and standards of the EuropeanAccreditation Council for Continuing Medical Education (EACCME®)which states that continuing medical education must be balanced,independent, objective, and scientifically rigorous.

Continuing medical educationAn application has been made to the EACCME® for CME accreditationof the EXCEMED conference “First world conference on luteinizinghormone in assisted reproductive technology” to be held on 27-28May 2016 in Naples, Italy.

The CME conference “First world conference on luteinizing hormonein assisted reproductive technology” to be held on 27-28 May 2016 inNaples, Italy will be submitted for CME accreditation from the ItalianMinistry of Health.

EXCEMED adheres to the principles of the Good CME Practice group(gCMEp).

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Faculty

Carlo AlviggiUniversity of Naples " Federico II" NaplesNaples, Italy

Claus Yding AndersenUniversity Hospital of CopenhagenCopenhagen, Denmark

Manish BankerNova IVI FertilityPulse Women's HospitalGujarat, India

Ernesto BoschInstituto Valenciano de Infertilidad Valencia, Spain

Klaus BühlerCentre for Gynaecological Endocrinology and Reproductive MedicineStuttgart, Germany

Nicola ColacurciOutpatient Fertility ClinicSecond University of NaplesNaples, Italy

Sandro C. EstevesANDROFERT - Andrology & Human Reproduction Clinic São Paulo, Brazil

Renato FanchinHospital A. Béclère and University Paris-SudClamart, France

Annapia Ferraretti SISMeR, Società Italiana Studi di Medicina della Riproduzione Bologna, Italy

Robert FischerFertility Centre HamburgHamburg, Germany

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Ilpo HuhtaniemiInstitute of Reproductive and Developmental BiologyHammersmith Campus, Imperial College LondonLondon, UK

Peter HumaidanFertility ClinicSkive Regional Hospital, and Faculty of HealthAarhus UniversityAarhus, Denmark

Antonio La MarcaUniversity of Modena and Reggio Emilia and Clinica EuginModena, Italy

Raoul OrvietoInfertility and IVF UnitDepartment of Obstetrics and GynaecologyThe Chaim Sheba Medical CenterTel Hashomer, Israel

Nikolaos PolyzosVrije Universiteit BrusselCenter for Reproductive MedicineUniversitair Ziekenhuis BrusselBrussels, Belgium

Eleonora PorcuDepartment of Medical and Surgical SciencesUniversity of BolognaBologna, Italy

Manuela SimoniUniversity of Modena and Reggio EmiliaModena, Italy

Sesh K. SunkaraAberdeen Fertility CentreAberdeen Maternity HospitalAberdeen, UK

Fulvio ZulloReggio Calabria UniversityCatanzaro, Italy

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Programme

Programme

Friday, 27 May 2016

From 12.00 RegistrationWelcome Lunch

13.30 EXCEMED Opening R. Fischer (Germany)

13.40 Local WelcomeG. De Placido (Italy)

13.50 IntroductionC. Alviggi (Italy) - S.C. Esteves (Brazil)

Chairs: R. Fisher (Germany) - E. Porcu (Italy)

14.00 L1: Physiology of LH and differences with hCGM. Simoni (Italy)

14.25 L2: Polymorphisms of LH and its receptorI. Huhtaniemi (UK)

14.50 L3: Facts and myths on the “Liasons dangerous”between LH and Progesterone C.Y. Andersen (Denmark)

15.15 Panel Discussion

16.00 Coffee break

Taking off from basic scienceSession I

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Legend: L : Lecture;

Chairs: F. Zullo (Italy) - M. Banker (India)

16.30 L4: Is there a role for LH in elderly patients?E. Bosch (Spain)

16.55 L5: LH in low prognosis patientsC. Alviggi (Italy)

17.20 L6: LH in antagonist cycles; is the story really written?R. Orvieto (Israel)

17.45 Panel Discussion

18.30 End of the first day

Flying through literature...Session II

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Saturday, 28 May 2016

Chairs: A. La Marca (Italy) - S.K. Sunkara (UK)

08.45 L7: The European point of view K. Buhler (Germany)

09.10 L8: The Indian point of view M. Banker (India)

09.35 L9: The Latin America approachS. C. Esteves (Brazil)

10.00 Panel discussion

10.45 Coffee break

Chairs: A. Ferraretti (Italy) - N. Colacurci (Italy)

11.15 L10: The flip side of LH R. Fanchin (France)

11.15 L11: ESHRE Bologna criteria: where are we? N. Polyzos (Greece)

11.40 L12: Matching patient and protocols in low prognosis; is it possible? P. Humaidan (Denmark)

12.30 Panel discussion

13.15 Concluding remarks

End of the conference

Closing lunch

Landing in the real worldSession III

What about next flightsSession IV

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General information

VenueThis conference will take place at the:

Royal Continental HotelVia Partenope, 38/4480121 Napoli

LanguageThe official language of this conference will be English.

CME ProviderEXCEMED - Excellence in Medical Education

Senior Programme Manager: Chloé XilinasT +39 06 420413 505 - F +39 06 420413 677chloe.xilinas@excemed.org

Medical Advisor: Alessandro Conforticonfale@hotmail.it

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Registration fee The registration fee is € 350,00 and includes:• Scientific sessions• Coffee breaks and luncheons• Dinner on 27 May 2016• Educational materials• Certificate of attendance

For registration and accommodation please contact:

Event Planet srlProject Coordinator: Morena Trematerra | Paola FedericoTel: +39 (0)81.5529399 - Fax: +39 (0)81.4206734LH2016@eventplanet.it

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