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Figure S1. Lee et al. 16. LL-37. A B. 12. 8. 4. Mabc. Relative mRNA expression. DEFB4. 20. (h) 0 3 6 18 48. 15. LL-37. 10. 5. DEFB4. 0. -actin. 0 3 6 18 48 (h). Mabc. 20. IL-1 . IC. α -Dectin-1. 15. U M U M. 10. - PowerPoint PPT Presentation
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Figure S1. Lee et al.
A
B
LL-37
IC
U M U M
IL-1
α-Dectin-1
DEFB4
-actin
LL-37
Mabc
(h) 0 3 6 18 48
DEFB4
-actin
Rel
ativ
e m
RN
A e
xpre
ssio
n
4
8
1216 LL-37
5
1015
20
00 3 6 18 48 (h)
Mabc
DEFB4
5
10
15
20
48
12
16
IL-1
LL-37
5
10
15
20
0
IC
U M U M
DEFB4
Rel
ativ
e m
RN
A e
xpre
ssio
n
α-Dectin-1
Figure S2. Lee et al.
Cas
p1
p1
0 /
-a
ctin
2468
0IL-1
p
17 /
-a
ctin
PIC
2468
Mabc
U SC
Mabc
PICU SC
0TN
F-α
(p
g/m
l)
400
800
1200
1600
U SC
Mabc
PIC
35 kD
24 kD
50 kD
35 kD
15 kD
7 kD
20 kD
15 kD
Casp1
pro-IL-1
┏Cell
Casp1 p10
IL-1 p17
┏SN
-actin
A
B
Figure S3. Lee et al.
A B
C
U M
siNS sip62
U M U M
Casp1
pro-IL-1
┏Cell
Casp1 p10
IL-1 p17
┏SN
35 kD
24 kD
50 kD
35 kD
15 kD
7 kD
20 kD
15 kD
U M
siNS sip62
70
140
210
280
0
IL-1
(n
g/m
l)
U M U M
IL-1
p
17 /
-a
ctin
U M
siNS
U M
sip62
2468
0U M
Cas
p1
p1
0 /
-a
ctin
2468
p62
-actin
Mabc
(h) 0 3 6 18 48
***
Non
esi
NS
sip6
2
p62-actin
-actin
Figure S4. Lee et al.C
ell
via
bil
ity
(%
)
80
0
120
40
sip62 siNSsip62
0 6 12 24 (h)
shp62
80
0
120
40
shNSshp62
p62
-actin
ATP (h) 0 3 6 18 48
nigericin 0 3 6 18 48 (h)
shNS
IL-1β
p62
-actin
U A N U A N U A N
shp62
A
B
C
U A N
shNS shp62
70
140
210
280
0
IL-1
(n
g/m
l)
U A N U A N
Figure S5. Lee et al.
