Fifth Annual Pathology Educational Symposiumpathology.jhu.edu/department/training/5thAnnualPathology... · 2017-08-10 · Fifth Annual Pathology Educational Symposium October 3-5,

Fifth Annual Pathology

Educational Symposium

October 3-5, 2017

Turner Building Concourse 720 Rutland Avenue

Baltimore, MD 21205

Sponsored by the Department of Pathology

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Description: This Continuing Education event is intended for all employees of the Johns Hopkins Medicine Department of Pathology and Johns Hopkins Medical Laboratories.

Cost: Free for all Pathology and Johns Hopkins Medical Laboratory employees.

Pre-registration is encouraged (and required to receive lunch):

Preregistration is open September 5 - September 25, 2017.

Preregistration can be done through the ActivTracker website for all JHMI staff:

http://pathology.jhu.edu/department/training/symposium.

cfm See your Supervisor for approval to attend during your normal working hours.

JHM I.D. badge is required for electronic attendance tracking. Registration: Turner Lower Concourse. Register only once on the first day of attendance to pick up materials.

Lunch: A sandwich or salad option will be available (while they last) free of charge for attendees who pre-registered for lunch and attend at least one session that day. (Lunch may not be available for those who did not pre-register for lunch.)

Lunch pick-up is in the Turner Lower Concourse:

Tuesday, October 3 12:00-12:45p

Wednesday, October 4 12:00-12:45p

Thursday, October 5 12:00-12:45p

http://pathology.jhu.edu/department/training/symposium.cfm


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Poster Session: Symposium poster presentations will be available only online from September 25 – October 20, 2017 at http://pathology.jhu.edu/department/training/posters.cfm. To receive P.A.C.E.® Continuing Education credit, questions must be answered for a minimum of five posters, and a minimum passing score of 80% must be achieved. No partial credits can be awarded, and answers must be emailed to [email protected] by October 23, 2017.

Examples: Questions answered for 5 posters with 80% receive 1.0 CEU. Questions answered for 10 posters with 80% receive 2.0 CEU.

Pre-registration is not required for the Poster Session.

Attendance Documentation & Certificate Instructions: 1. Swipe I.D. badge or sign in for all sessions attending.

(NO CE credit will be available for those who arrive more than 10 minutes after the start time.)

2. Record Session Code on Attendance Documentationform (provided at the end of the session).

3. Turn in completed Attendance Documentation form atregistration desk or email to Symposium Committee atend of the symposium. Both sign-in / swipe-in &Attendance Documentation form are required to receiveyour P.A.C.E.® certificate.

4. Certificate and evaluations will be emailed to attendeeswithin three weeks of the Symposium.

Volunteer Opportunities: If you would like to help with the

Symposium, please register at http://signup.com/go/PtvQJRG

to sign up. Volunteers are needed in several areas: Registration Desk: Hand out materials & give directions to rooms. Moderator: Introduce session and speaker. Room Lead: Assist attendees in swiping (ActivTracker) / signing in for

their session.

Lunch: Assist attendees with obtaining lunch. Johns Hopkins Medicine is approved as a provider of continuing education programs in the clinical laboratory sciences by the ASCLS P.A.C.E.® Program.

http://pathology.jhu.edu/department/training/posters.cfm

mailto:[email protected]

http://signup.com/go/sXySEyw

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Tuesday, October 3, 2017

8:00a-3:30p: Registration (Turner Concourse)

Opening Session 8:30a-9:30a Room: Turner Auditorium

Music and Medicine

Course # 612-403-17 / 1.0 credit hours

Edward F. McCarthy, MD Professor of Pathology and Orthopaedic Surgery Johns Hopkins University School of Medicine

Level of Instruction: Basic Category: General Target Audience: All are welcome Description: This talk will explore the relationship of music to medicine. It will discuss the idea of health as musical harmony. We will look at the body as a musical instrument and describe the physiologic effects of music on the body. We look at health issues of musicians. We will look at doctors who are musicians and discuss illnesses of famous composers and how music affected their work. Objectives: At the completion of the presentation, the audience will be able to:

List the effects of music on the body

Discuss the illnesses of three composers and how their disease affected their music

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Tuesday, October 3, 2017 9:45a–10:45a Room: TBA

What Have You Done for Your Community Lately?


Lorraine Wilson Youth Programs Coordinator Johns Hopkins Medicine

Bruce Kranig Senior Relationship Manager United Way of Central Maryland

Level of Instruction: Basic Category: General Target Audience: All are welcome Description: Medical centers and hospitals serve their surrounding communities by providing healthcare, but other opportunities are available to become involved both individually and as an organization. This presentation will highlight some opportunities to help change the odds for families and communities. Objectives: At the completion of the presentation, the audience will be able to:

Support the HopkinsLocal initiative by supporting opportunities to serve Baltimore’s youth population through healthcare explorations and summer employment experiences

Identify how the United Way of Central Maryland is focused on strengthening the basic building blocks of a self-sufficient life—education, housing, employment, and health

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9:45a–10:45a Room: TBA

Transgender 101 - Fundamentals for Health Care

Practitioners Course # 612-405-17 / 1.0 credit hours

Paula Neira, JD, MSN, RN, CEN Clinical Program Director Center for Transgender Health Johns Hopkins Health Systems

Level of Instruction: Basic Category: Diversity Target Audience: All are welcome

Description: This presentation provides fundamental cultural competency education to clinical and non-clinical audience members practicing across all settings. The presentation addresses unconscious bias and the stereotypes and myths about the transgender community which impact health care disparities. The presenter will describe at least three communication skills that can be used to demonstrate dignity and respect for this patient population and help foster a welcoming and supportive environment. Lastly, the presentation will address challenges that arise in electronic medical records and other systems when dealing with transgender patients. Objectives: At the completion of the presentation, the audience will be able to:

Discuss the impact of unconscious bias, stigma and discrimination on the healthcare disparities impacting the transgender community

Demonstrate inclusion and respectful communications for interacting with transgender individuals through use of proper terminology, proper address, and proper questioning techniques

Identify challenges in the electronic medical record and other systems that impair transgender healthcare delivery

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9:45a–10:45a Room: TBA

Are Natural Killer (NK) Cells Still Hidden

Superheroes in the Fight Against Cancer and

Infection?


Christopher J. VandenBussche, MD, PhD

Assistant Professor of Pathology Johns Hopkins University School of Medicine

Level of Instruction: Intermediate Category: Immunology, Microbiology Target Audience: All are welcome Description: Natural killer (NK) cells have a critical role in the destruction of cancer cells and cells infected by viruses. While modern immunology continues to heavily study T-cells, B-cells, and antibodies, less is known about NK cells and their true impact on disease. This lecture will explain the basic immunobiology of NK cells, present studies that suggest the importance of NK cells in fighting certain cancers and infections, and explain how the genes we inherit impact the activity of our own NK cells. Objectives: At the completion of the presentation, the audience will be able to:

Describe how natural killer (NK) cells link innate and adaptive immunity

Explain how natural killer (NK) cells identify malignant and infected cells

Define "immunogenetics" and describe how immunogenetics impacts an individual's NK cells

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11:00a–12:00p Room: TBA

Brain Invaders: Detecting, Classifying, and Killing

Infiltrating Gliomas


Heather Ames, MD, PhD Research/Clinical Fellow, Neuropathology Johns Hopkins University School of Medicine

Level of Instruction: Intermediate Category: Histology Target Audience: All are welcome Description: Infiltrating gliomas are the most common adult primary tumor of brain tissue and they are highly sneaky and adaptable. Our ability to detect and classify these tumors has been dependent on a keen eye, but advances in brain tumor genetics have improved our ability to see these cancer cells for what they are – resilient and stealthy invaders. Additionally, new markers give us important clues to prognosis. Ongoing research is using our understanding of the genetic signatures of these subtypes to specifically target malignant cells. Objectives: At the completion of the presentation, the audience will be able to:

Define a glioma

Describe the main subtypes of glioma and their prognosis

Recognize the histologic challenges of glioma diagnosis

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11:00a–12:00p Room: TBA

Thromboelastography: A Snapshot of Coagulopathy


Courtney E. Lawrence, MD Fellow, Transfusion Medicine Johns Hopkins University School of Medicine

Level of Instruction: Intermediate Category: Hematology, Blood Bank Target Audience: All are welcome Description: Although thromboelastography (TEG) has been around for over half a century, its clinical use to manage bleeding has only become widely utilized in recent years. As a rapid assessment of multiple parameters of hemostasis, TEG is frequently utilized for transfusion management in post-operative patients and in patients with complex coagulopathic conditions, including liver dysfunction and those on extracorporeal membrane oxygenation (ECMO) support. In this talk, we will discuss the basics of TEG performance and interpretation, the limitations of this testing, and choosing management strategies based on TEG results. Objectives: At the completion of the presentation, the audience will be able to:

Explain the mechanics of hemostasis and clot formation

Describe the of technical aspects of thromboelastography and its limitations

Identify the parameters of a thromboelastogram and their clinical significance

Recommend transfusion management based on thromboelastography results

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1:00p–2:00p Room: TBA

Anaerobic Bacteriology: Oxygen Is the Enemy


Brandon Ellis, MLS(ASCP)CM Supervisor, Microbiology The Johns Hopkins Hospital

Level of Instruction: Intermediate Category: Microbiology Target Audience: All are welcome Description: Anaerobic bacteria do not require oxygen for growth and are an integral component of the human microbiome. Since exposure to oxygen can inhibit or prevent the growth of anaerobic bacteria, special collection and culture methods are required for diagnosing anaerobic infections. This discussion will highlight the impact of oxygen on anaerobic bacteria and the routine methods used for their cultivation and identification. In addition, medically important anaerobes and their associated diseases will be discussed, including some of the most powerful toxins known to man. Objectives: At the completion of the presentation, the audience will be able to:

Describe the effects of oxygen on obligate anaerobic bacteria

Discuss methods utilized for specimen collection, culture, and identification of anaerobic bacteria

List medically important anaerobic bacteria and their associated diseases

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How Do We Personalize Medicine and Make It

Precise?


Kevan Salimian, MD, PhD Resident Physician, PGY-3, Department of Pathology Johns Hopkins University School of Medicine

Level of Instruction: Basic Category: Molecular Target Audience: All are welcome Description: Personalized medicine refers to the pursuit of tailoring precise treatments to the individual patient. The goal of this emerging field is to maximize therapeutic potential while minimizing side effects to the patient. We will explore the role the pathology department plays to ensure that medicine is delivered in a personalized and precise manner. Objectives: At the completion of the presentation, the audience will be able to:

Define personalized medicine and explain how treatments are tailored to patients

Describe the role pathology plays in delivering personalized medicine

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Febrile Transfusion Reactions


Jackie Birkness, MD Resident Physician, PGY-2, Department of Pathology Johns Hopkins University School of Medicine

Level of Instruction: Basic Category: Blood Bank Target Audience: All are welcome Description: This talk will cover several types of transfusion reactions that present with febrile symptoms and will include acute hemolytic, septic, transfusion-related acute lung injury (TRALI), and febrile non-hemolytic reactions. The talk will focus on clinical presentation, treatment, and implications for future transfusions. Objectives: At the completion of the presentation, the audience will be able to:

Recognize common transfusion reactions based upon clinical scenarios

Explain management of common transfusion reactions

Explain the implications for future transfusions after a transfusion reaction has occurred

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Mass Spectrometry in the Clinical Laboratory:

Enabling Precise Analytical Measurements to Assess

Patient Health


Stefani Thomas, PhD Clinical Fellow, Clinical Chemistry Division, Department of Pathology Johns Hopkins University School of Medicine

Level of Instruction: Intermediate Category: Clinical Chemistry Target Audience: All are welcome Description: Mass spectrometry is a highly specific and sensitive analytical tool that can be used to accurately and reliably measure a wide range of clinically relevant analytes for the evaluation of patient health. Several laboratories use mass spectrometry to monitor therapeutic and frequently abused drugs, perform endocrine tests and aid in the diagnosis of infectious disease, and the use of mass spectrometry for clinical diagnostics is increasing. This presentation will introduce the fundamental principles of mass spectrometry with specific attention given to examples of currently used clinical applications of mass spectrometry. Various challenges that clinical laboratories face when implementing mass spectrometry will also be addressed. Objectives: At the completion of the presentation, the audience will be able to:

Explain the fundamental principles of mass spectrometry

Describe examples of how mass spectrometry assays are used in the clinical laboratory

Evaluate the advantages and disadvantages of mass spectrometry as a diagnostic tool in the clinical laboratory

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Modeling the Academic Biorepository: The Daily

Operations of the Genetic Resource Core Facility


Melissa V. Olson, PhD Co-Director, Genetic Resource Core Facility (GRCF) Director, GRCF Biorepository & Cell Center Johns Hopkins University School of Medicine

Level of Instruction: Intermediate Category: Repository, Research Target Audience: All are welcome Description: The goal of most biorepositories is to collect, process, store, and distribute human biospecimens for use in basic, translational, and clinical research. As healthcare rapid moves toward a “personalized medicine” approach with tailored decisions and medical practices to individual patients, the practice of biobanking specimens is also gaining popularity. The true power of the biorepository for discovery is directly related to the number of biospecimens, how they were collected, processed and stored, their linkage to clinical and phenotype data, and availability of tools to query the collection. Objectives: At the completion of the presentation, the audience will be able to:

Explain the structure, management, quality monitoring, and financial support utilized today by the GRCF Biorepository

Identify the various biospecimen collection types and examples of outcomes

Describe the logistics of cryopreservation units and storage practices

Discuss the “Change to the Common Rule” for biospecimen collections

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Ethical Considerations in Pathology


Margaret Cocks, MD Resident Physician, PGY-4, Department of Pathology Johns Hopkins University School of Medicine

Level of Instruction: Basic Category: General Target Audience: All are welcome

Description: There is a need for better training and more resources to address the often unique ethical scenarios encountered in both anatomic and clinical pathology. The goal of this talk is to bring to light some of the ethical complexities faced in day-to-day pathology practice and to provide tools to navigate these difficult situations. This talk will begin with a broad introduction to medical ethics and then explore specific practical scenarios encountered in pathology. It will provide a foundation to think about medical ethics and its application to pathology.

Objectives: At the completion of the presentation, the audience will be able to:

Define the basic principles of medical ethics

Discuss how medical ethical principles may apply to pathology

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Wednesday, October 4, 2017


8:30a-9:30a Room: TBA

An Overview of Interesting Cases Seen in the Clinical

Immunology Laboratory


Patrizio Caturegli, MD, MPH Associate Professor of Pathology and Medicine Johns Hopkins University School of Medicine

Level of Instruction: Intermediate Category: Immunology Target Audience: All are welcome Description: Review the impact of the Clinical Immunology Laboratory in the diagnosis and management of patients. Objectives: At the completion of the presentation, the audience will be able to:

Explain the principles of immunoassays

Discuss the clinical utility of immunology tests

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Music for Prevention and Cure: Songs About Diseases Course # 612-417-17 / 1.0 credit hours

Timothy Amukele, MD, PhD Director of Clinical Laboratories Johns Hopkins Bayview Medical Center

Level of Instruction: Basic Category: General Target Audience: All are welcome Description: Shakespeare wrote, “If music be the food of love, play on.” Music is also the food of disease prevention and cure. In this talk we play and discuss specific songs that do this. Objectives: At the completion of the presentation, the audience will be able to:

List specific songs that were used for public health promotion

Describe how specific compositional devices are used to convey healthcare messages

Discuss specific diseases that songs have been written about

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The Importance of Histopathology in Kidney Disease

in 2017: Implications for Research and Diagnosis


Avi Z. Rosenberg, MD, PhD Assistant Professor of Pathology Johns Hopkins University School of Medicine

Level of Instruction: Intermediate Category: Histology Target Audience: All are welcome Description: Kidney disease is a growing affliction with many diagnostic entities encompassing the array of possibilities. Despite advances in molecular diagnostics, the kidney biopsy remains an integral part of clinical practice and is similarly necessary to drive research efforts in the field of primary kidney disease etiology, progression, and kidney transplant outcomes. We will discuss the overview of kidney anatomy, histology and broad view of diagnostic entities observed in daily practice. We will then explore recent examples from our research experience where histopathology integration with molecular and clinical information resulted in a better understanding of diseases that affect kidney disease cohorts. Objectives: At the completion of the presentation, the audience will be able to:

Appreciate the complexity of the human kidney

Describe the complexity and array of human kidney diseases

Recognize the importance of histopathology to the success of kidney research in 2017

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PSA Screening Controversies and New Prostate

Cancer Tests


Claire E. Knezevic, PhD Clinical Fellow, Clinical Chemistry Division, Department of Pathology Johns Hopkins University School of Medicine

Level of Instruction: Intermediate Category: Clinical Chemistry Target Audience: All are welcome Description: Approximately 12% of men will be diagnosed with prostate cancer at some point during their lifetime. However, only about one fifth of these are cancers will be fatal. This presentation will discuss the controversies surrounding prostate-specific antigen (PSA) screening for prostate cancer, specifically how increased detection of slow-growing cancers can lead to overdiagnosis and overtreatment. Strategies to improve PSA implementation and to measure other forms of PSA will be covered and compared to PSA screening alone. New prostate cancer tests that measure non-PSA biomarkers will also be discussed. Objectives: At the completion of the presentation, the audience will be able to:

Describe how PSA screening was originally used in the detection of prostate cancer

Explain the downsides of PSA screening and prostate cancer overdiagnosis

Name new tests/strategies that either improve upon PSA testing or provide alternative methodologies

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RH Serological and Molecular Diversity


Patricia A. R. Brunker, MD, DPhil (Oxon) Medical Director, American Red Cross Assistant Professor of Pathology, Johns Hopkins University School of Medicine

E. Nadjay Cambre, MLS(ASCP)CMSBBCM Lead Technologist, Transfusion Medicine The Johns Hopkins Hospital

Level of Instruction: Advanced Category: Blood Bank Target Audience: All are welcome Description: The Rh system is the second most important blood group in transfusion medicine due to its immunogenicity and its clinical significance. This presentation will discuss the Rh genes and antigens that can lead to complicated antibody problems and difficult decision making in regard to transfusion and pregnancy management. Objectives: At the completion of the presentation, the audience will be able to:

Describe the gene location, allele, and characteristics of RHD and RHCE

Describe the mechanism of the D-negative phenotype

Discuss the three categories of weak D / Partial D

Identify Rh antibodies produced by altered RHD and RHCE expression

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Taking Care of Patients with Special Needs


Mustapha Saheed, MD Associate Director of Clinical Affairs, Dept. of Emergency Medicine Assistant Professor of Emergency Medicine Johns Hopkins University School of Medicine

Level of Instruction: Basic Category: Diversity Target Audience: All are welcome Description: The Emergency Department serves all types of patients who arrive without advance notice. Learn how the ED promptly handles patients who require special accommodations and provides them with patient- and family-centered care in various ways, including communication, positive patient identification, and consent for treatment. Please bring any questions about caring for patients with special needs and its impact on Pathology. Objectives: At the completion of the presentation, the audience will be able to:

Describe what patient- and family-centered care means

Identify at least two types of patients and considerations or services that the health care provider can utilize to provide medical care.

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11:00a-12:00p Room: TBA

Configuring the Epic Hospital Information Systems to

Work for the Laboratory: Orders, Specimen

Collection, Metrics, and What’s Ahead!


Peter Michael Huppenthal, MS, MT Director, Pathology Information Technology (Enterprise) Johns Hopkins Medicine

Level of Instruction: Basic Category: Phlebotomy, Computer Target Audience: All are welcome Description: This session will provide information specific to the Epic Hospital Information Systems (H.I.S.):

1. Creative ways that we are attempting to control provider ordering

2. Review the laboratory specimen collection process in Epic 3. Provide an overview of Tableau analytics 4. Highlight future developments of the integrated Beaker

Laboratory Information System (LIS) Objectives: At the completion of the presentation, the audience will be able to:

State the basic features of Provider Ordering in Epic

Describe key aspects of the Epic Positive Patient Identification (PPID) specimen collection workflow

Identify the power of Tableau Analytics

Anticipate what’s ahead for Surgical Pathology and Molecular Pathology

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11:00a-12:00p Room: TBA

An Overview of Immunotherapy for Treatment of

Urothelial Carcinoma


Derek B. Allison, MD Resident Physician, PGY-3, Department of Pathology Johns Hopkins University School of Medicine

Level of Instruction: Intermediate Category: Immunology Target Audience: All are welcome Description: Our understanding of the relationship between the immune system and cancer is a growing field with major implications. Specifically, bladder cancer has been shown to be susceptible to immunotherapy, first with Bacillus Calmette-Guérin (BCG) immunotherapy, and now with anti-PD 1/PD-L1 therapy. This talk will give an overview of current and emerging immunotherapies for the treatment of bladder cancer with emphasis on the immunologic mechanisms. Objectives: At the completion of the presentation, the audience will be able to:

Describe the relationship between the immune system and bladder cancer

Explain the theory and results of several current immunotherapies for bladder cancer

Describe emerging therapies for bladder cancer treatment

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11:00a-12:00p Room: TBA

The Path to Molecular Diagnostic Testing


Doreen Nguyen, MD Postdoctoral Fellow, Department of Pathology Johns Hopkins University School of Medicine

Level of Instruction: Intermediate Category: Molecular Target Audience: All are welcome Description: Where does a specimen go for molecular testing? Who is involved, and why does it take so long? To understand the work behind a molecular pathology report, we will follow a specimen from Surgical Pathology to the Molecular Diagnostics Laboratory. There will be a brief discussion about the clinical tests offered by the Molecular Diagnostics Laboratory, along with case presentations that highlight the clinical utility of molecular tumor profiles for diagnosis, prognosis, and therapeutic decision-making. Objectives: At the completion of the presentation, the audience will be able to:

Identify key processing steps of a specimen for molecular testing

Identify ways in which molecular testing improves patient care and assists in clinical management decisions

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1:00p-2:00p Room: TBA

Laboratory Hematology Cellular Analysis: Providing

Clinicians What They Need


Thomas S. Kickler, MD Director, Division of Hematology Laboratory The Johns Hopkins Hospital

Level of Instruction: Intermediate Category: Hematology Target Audience: All are welcome

Description: This talk will provide an up-to-date discussion on advances in blood cell counting, including technology and application of new parameters, along with applications of telehematology in a healthcare system. Objectives: At the completion of the presentation, the audience will be able to:

Introduce blood cell counting principles

Describe new technology in cell counting and analysis

Describe new blood cell parameters that improve diagnosis

Describe applications of telehematology in patient care

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Disruptive Behaviors in the Workplace


Susan Lee Bathgate Manager, Safe at Hopkins Program Johns Hopkins Medicine

Level of Instruction: Basic Category: General Target Audience: All are welcome Description: From inappropriate and disrespectful behaviors to bullying and workplace violence concerns, disruptive behaviors in the workplace have a negative impact and undermine a culture of safety. Early identification and reporting of disruptive behaviors are key in promoting a safe work environment for all employees. Attendees will learn what "disruptive behaviors" mean, their role in preventing disruptive behaviors from escalating, and how to report concerns. Objectives: At the completion of the presentation, the audience will be able to:

Explain the Johns Hopkins continuum of disruptive behaviors at work

Identify who to contact to report concerns of disruptive behaviors

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Update on Diagnostic Assays for Rapid Detection of

Bacteremia


Karen Carroll, MD Director, Division of Medical Microbiology Professor of Pathology Johns Hopkins University School of Medicine

Level of Instruction: Intermediate Category: Microbiology Target Audience: All are welcome Description: Bacteremia is a significant cause of morbidity and mortality. Time to appropriate therapy has been shown to impact patient outcome. Several novel diagnostic platforms, mostly performed on positive blood culture bottles, have become available to shorten the detection time of organisms responsible for bacteremia. This presentation will review these diagnostic platforms and discuss their impact on patient management. Objectives: At the completion of the presentation, the audience will be able to:

Discuss the importance of bloodstream infections

Identify the currently available assays for identification of organisms from positive blood cultures

Appreciate the difficulty of direct from whole blood testing

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Description: This presentation provides fundamental cultural competency education to clinical and non-clinical audience members practicing across all settings. The presentation will address unconscious bias and stereotypes and myths about the transgender community which impact health care disparities. The presenter will describe at least three communication skills that can be used to demonstrate dignity and respect for this patient population and help foster a welcoming and supportive environment. Lastly, the presentation will address challenges that arise in electronic medical records and other systems when dealing with transgender patients. Objectives: At the completion of the presentation, the audience will be able to:


Demonstrate inclusion and respectful communications for

interacting with transgender individuals through use of proper terminology, proper address, and proper questioning techniques


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Neonatology and Pathology: Made for Each Other


Amaris Keiser, MD Assistant Professor of Pediatrics, Division of Neonatology Johns Hopkins University School of Medicine

Level of Instruction: Basic Category: Microbiology, Hematology, Blood Bank Target Audience: All are welcome

Description: This talk will provide a brief overview of the field of neonatology (history and evolution of medical therapies offered), and will describe the important ways that the NICU relies on the blood bank to provide the highest level of medical care to a particularly vulnerable patient population. Objectives: At the completion of the presentation, the audience will be able to:

Describe the successes and challenges in the advancement of the field of neonatology

Appreciate the ways in which the pathology specialties provide vital information to the clinicians who care for this particularly vulnerable patient population

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Thursday, October 5, 2017



A “Walking Tour” of the Dome in Pictures


Jon R. Christofersen, MA Medical Photographer Johns Hopkins University School of Medicine

Level of Instruction: Basic Category: General Target Audience: All are welcome

Description: A unique visual “walking tour” of the Billings Building where you can remain seated. This tour will showcase areas that most employees are unable to gain access to. This visual tour will help you gain an appreciation for the architecture of a beautiful building that many have walked past but may have never stopped to look at. Objectives: At the completion of the presentation, the audience will be able to:

Appreciate the architecture of the Billings Building

Discover a unique viewpoint of the Billings Building

Learn about the history of this landmark Johns Hopkins Hospital building

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Hemolytic Disease of the Fetus and Newborn:

Protecting Our Littlest Patients


Heather Smetana, MLS(ASCP)CMSBBCM Lead Technologist, Transfusion Medicine The Johns Hopkins Hospital

Level of Instruction: Intermediate Category: Blood Bank Target Audience: All are welcome

Description: The anticipation of a new life is so exciting and wonderful, but just imagine hearing that you are attacking your child and may kill him or her – that is what happens with Hemolytic Disease of the Fetus and Newborn (HDFN). This presentation will discuss why the mother’s antibodies attack her child, review recent HDFN cases, and learn how we can protect the fetus. Objectives: At the completion of the presentation, the audience will be able to:

Explain the pathophysiology of Hemolytic Disease of the Fetus and Newborn (HDFN)

Describe treatment options for the fetus who has HDFN

Select appropriate blood products for intrauterine transfusion and newborn red cell exchange in cases of HDFN

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Introduction to Bone Marrow Aspiration:

Morphologic and Flow Cytometric Correlation


Austin McCuiston, MD Fellow, Hematopathology Johns Hopkins University School of Medicine

Level of Instruction: Basic Category: Hematology Target Audience: All are welcome

Description: This will be a brief introduction to flow cytometry. We will discuss bone marrow aspiration and differential counts as it relates to flow cytometry. Emphasis will be placed on acute leukemias, myelodysplastic syndrome, and lymphomas which commonly involve the bone marrow. Objectives: At the completion of the presentation, the audience will be able to:

Recognize normal bone marrow elements and correlate them with basic flow cytometric immunophenotypes

Recognize common bone marrow diseases and how they correlate with flow cytometric data

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Autopsy Assembled: Cutting-edge Techniques and

Fascinating Cases

Warning: Please be advised of the graphic nature of the images in this

presentation as they have been taken from actual autopsies.


Jody E. Hooper, MD Director, Autopsy Division Director, Legacy Gift Rapid Autopsy Program Assistant Professor of Pathology Johns Hopkins University School of Medicine

Level of Instruction: Basic Category: Autopsy Target Audience: All are welcome

Description: Very few people have the opportunity to see an autopsy and learn firsthand how it is performed. Exceptional diagnostic techniques contribute greatly to diagnosis, education, research, and care for families. This talk will give a detailed visual tour of an autopsy, show time-honored surgical techniques as well as approaches to special dissections and how they preserve the dignity and cosmetic appearance of the patient. The use of ancillary testing such as microbiology cultures or molecular testing will be briefly reviewed. Gross and microscopic findings of autopsy cases with unexpected, illuminating, and anatomically fascinating findings will be shown in detail. Objectives: At the completion of the presentation, the audience will be able to:

Describe how an autopsy is performed and teach others how the process works

Describe how additional laboratory testing can contribute to autopsy diagnostics

Cite autopsy cases which have contributed to diagnostic quality, education, and care for families of deceased patients

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Laboratory Diagnostics of Celiac Disease and

Gluten-related Disorders


Daniela Cihakova, MD, PhD, D(ABMLI)

Associate Professor of Pathology Johns Hopkins University School of Medicine

Level of Instruction: Intermediate Category: Immunology Target Audience: All are welcome

Description: Celiac disease is an autoimmune-mediated inflammation of the small intestine, strongly dependent on HLA-DQ2 and HLA-DQ8 haplotypes characterized by intolerance of dietary gluten present in wheat, rye, and barley. The diagnostic criteria for celiac disease have remained unchanged for more than 20 years. However, in 2013 the American College of Gastroenterology and independently the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition each published new guidelines for the diagnosis of celiac disease. The presenter will summarize the main changes with the emphasis on laboratory testing in diagnosis of celiac disease. Besides celiac disease, there are other gluten-related disorders -- wheat allergy and gluten sensitivity. There is a great interest in gluten sensitivity and its relation to other disorders and overall health. We will discuss current laboratory methods used to diagnose gluten sensitivity. Objectives: At the completion of the presentation, the audience will be able to:

Explain new evidence-based guidance for diagnosis of celiac disease

Discuss the use of different laboratory tests in diagnosis of celiac disease

Describe clinical presentation and laboratory findings of other gluten-related disorders

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You're Testing in What? Antiretroviral Drug

Measurements in Alternative Matrices to Support

Clinical Trials


Mark Marzinke, PhD, DABCC Director, Preanalytics and General Chemistry Director, Clinical Pharmacology Analytical Laboratory Associate Professor of Pathology and Medicine Johns Hopkins University School of Medicine

Level of Instruction: Intermediate Category: Clinical Chemistry Target Audience: All are welcome

Description: During this session, the presenter will introduce the topic of antiretroviral drugs used for HIV management and prevention. We will focus on how therapeutic medications can deposit in anatomical sanctuary sites and the benefits of analytical methodologies that may be used to measure drug concentrations in alternative matrices. The session will highlight the importance of pre-analytical and analytical optimization in the development and validation of LC-MS/MS assays to support clinical trials. Objectives: At the completion of the presentation, the audience will be able to:

Describe the role of antiretrovirals in the management of HIV

Discuss the role of antiretrovirals in anatomical sanctuary sites

Identify pre-analytical and analytical considerations for the development, validation, and implementation of bioanalytical tools to answer pharmacokinetic-driven questions

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11:00a-12:00p Room: TBA

Weird Micro Returns: What's in YOUR Water?


Paula C. Mister, MS, MT, SM(ASCP)CM Educational Coordinator, Clinical Microbiology The Johns Hopkins Hospital

Level of Instruction: Intermediate Category: Microbiology Target Audience: All are welcome

Description: Test your knowledge of microbiology and learn about current interesting cases and organisms related to water from the Johns Hopkins Clinical Microbiology Lab in a lively, interactive format. A brief discussion of current methodology for identification and treatment follows each case. Objectives: At the completion of the presentation, the audience will be able to:

Integrate information from patient history, symptoms, lab results, and other clues provided to postulate microbiologic pathogens from the cases presented

Appreciate the potentially unusual pathogens from water sources, or from unusual body sites, in the clinical lab

Describe laboratory methods to detect, identify, and treat these pathogens in an accurate and timely way

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11:00a-12:00p Room: TBA

Hiding in Plain Sight: How Does Our Immune

System Recognize and Respond to Cancer?


Elizabeth Thompson, MD, PhD Assistant Professor of Pathology Johns Hopkins University School of Medicine

Level of Instruction: Intermediate Category: Histology, Immunology Target Audience: All are welcome

Description: The idea that our immune system can recognize tumor cells as "foreign," just as it does a virus or other pathogen, has been around for over 100 years. Our knowledge of how exactly this process occurs has exploded over the past 30 years, and the past 5-10 years have seen an unprecedented pace of new immunotherapeutic treatments arrive in clinics. This talk will explore the delicate balance the immune system must strike between recognizing and eliminating threats and damaging normal tissues, and how that impacts the development and spread of cancers. Understanding this balance forms the basis for the new field of "immuno-oncology," which is currently generating the most promising and exciting new therapies for cancer since the advent of chemotherapy. We will discuss how these new treatments are changing the paradigm of cancer therapy. Objectives: At the completion of the presentation, the audience will be able to:

Describe the basic components of the immune system and how they work together to recognize a tumor cell

Describe at least one way tumor cells can "evade" the immune system

Describe at least one way oncologists are harnessing the immune system to treat tumors

38


11:00a-12:00p Room: TBA

Safety Incident Rates and Trends in Pathology


Anita Stone, MS, CSPHA Associate Director, Dept. of Health, Safety, and Environment Johns Hopkins Medicine

Level of Instruction: Basic Category: Safety Target Audience: All are welcome

Description: We will review with the group occupational injuries reported to the Occupational Injury Clinic for the past three years by the Pathology Department. The most common injuries will be discussed along with ways to prevent reoccurrence. An update to bloodborne pathogens will also be discussed. Objectives: At the completion of the presentation, the audience will be able to:

Identify the most common incident trends in Pathology

Give examples of how to prevent injuries from occurring, and how to report properly if they do occur

Give examples of the different types of bloodborne pathogen diseases, how to prevent exposure, how to respond if exposed, and how to properly clean up body fluid spills

39



Phlebotomy and Its Impact on Laboratory Testing:

The Importance of Obtaining a Good Quality

Specimen for Analysis


Daniela Flores, MLT(ASCP) NHA-Certified Phlebotomist Research Specialist, Rheumatology Division Johns Hopkins University School of Medicine

Level of Instruction: Intermediate Category: Phlebotomy Target Audience: All are welcome

Description: This presentation will focus on quality requirements related to sample collection and its impact on laboratory testing. It will include a review of best practices in sample collection, as well as a description of sources of error in the process of venipuncture and how such errors can affect patient care. Objectives: At the completion of the presentation, the audience will be able to:

Recognize sources of error when performing phlebotomy

Recognize factors that affect sample collection and results

Identify areas of improvement in sample collection to better serve patients

Acknowledge the risks involved in deviating from the standard of care in phlebotomy

40



Essential Oils and Future Antibiotics – New Weapons

against Emerging “Superbugs”?


Nicole Parrish, PhD, MHS, D(ABMM) Assistant Professor, Department of Pathology, Division of Medical Microbiology Director, Medical Mycobacteriology Johns Hopkins University School of Medicine

Level of Instruction: Intermediate Category: Microbiology Target Audience: All are welcome

Description: Detail the history of essential oils, antimicrobial activity, and their possible mechanisms. Objectives: At the completion of the presentation, the audience will be able to:

Appreciate the data from the study which shows that many essential oils have potent antimicrobial activity

Describe how antibiotic activity is selective in some cases

Visualize how these oils may provide the scaffold to develop new drugs

41



Hyperviscosity Syndrome


Lais Osmani, MD Resident Physician, PGY-3, Department of Pathology Johns Hopkins University School of Medicine

Level of Instruction: Intermediate Category: Blood Bank, Apheresis, Hematology Target Audience: All are welcome

Description: Hyperviscosity syndrome is an oncologic emergency which can result in significant morbidity and mortality if left untreated. This talk will cover the pathophysiology, diagnosis, and clinical management of hyperviscosity syndrome. Additionally, this talk will focus on the effects of increased blood viscosity on the measurement and analysis of multiple laboratory tests. Objectives: At the completion of the presentation, the audience will be able to:

Recognize hyperviscosity syndrome based upon clinical presentation and laboratory findings

Explain the pathophysiology of increased blood viscosity and the management of hyperviscosity syndrome

Explain the effects of increased blood viscosity on the measurement and analysis of multiple lab studies

42



Telomere Length Testing in Clinical Settings


Mary Armanios, MD Professor of Oncology and Pathology Johns Hopkins University School of Medicine

Level of Instruction: Intermediate Category: Molecular Target Audience: All are welcome

Description: We will discuss the role of telomeres, telomerase and disease with an emphasis on the emphasis and relevance of telomere length testing in hospital-based settings. Objectives: At the completion of the presentation, the audience will be able to:

Explain the link between telomere length abnormalities, aging and cancer

Identify some of the indications of telomere length testing in clinical settings

43







Description: This presentation provides fundamental cultural competency education to clinical and non-clinical audience members practicing across all settings. The presentation will address unconscious bias and the stereotypes and myths about the transgender community which impact health care disparities. The presenter will describe at least three communication skills that can be used to demonstrate dignity and respect for this patient population and help foster a welcoming and supportive environment. Lastly, the presentation will address challenges that arise in electronic medical records and other systems when dealing with transgender patients. Objectives: At the completion of the presentation, the audience will be able to:


Demonstrate inclusion and respectful communications for interacting with transgender individuals through use of proper terminology, proper address, and proper questioning techniques


44

Fifth Annual Pathology

Educational Symposium Schedule at a Glance

Color Key: General Chemistry Immunology

Surgical Pathology Hematology Molecular

Blood Bank/Pheresis Microbiology Phlebotomy

Poster Session: Poster presentations will be available online at http://pathology.jhu.edu/department/training/posters.cfm only from September 25 – October 20, 2017. To receive P.A.C.E.® Continuing Education credit, questions must be answered for a minimum of five posters, and a minimum passing score of 80% must be achieved. No partial credits will be awarded and answers must be emailed to [email protected] by October 23, 2017.

Examples: Questions answered for 5 posters with 80% receive 1.0 CEU.

Questions answered for 10 posters with 80% receive 2.0 CEU.

Pre-registration is not required for the Poster Session.

Pathology Symposium Committee

Chairs: Lorraine Blagg and Vanessa Rodas-Eral

Maria Barata Alexis Jones Karen Bordenet Renata Karlos Chris Calvelli Anne Leach Barbara Detrick Paula Mister Linda Gluck Nancy Nath Monica Gray Missy Olson Tammy Heacock Doris Pendergrass Rosemary Hines Eunhee Rim Christine Hostetter Marian Turpin Brittney Howard Holly White

Debbie Williams

http://pathology.jhu.edu/department/training/posters.cfm

mailto:[email protected]

45

Lun

ch

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om

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om

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Re

gistra

tion

(Low

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rne

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nc

ou

rse)

Tue

sda

y

Oc

tob

er 3

, 20

17

Re

gistra

tion

(8a

- 3:3

0p

)

8:0

0

AM

Mu

sic and

Med

icine

8:3

0 A

M

NK

Cells:

Hid

den

Sup

erhero

es?

Transgen

der

10

1

Wh

at Have Yo

u

Do

ne fo

r You

r

Co

mm

un

ity Lately?

9:4

5 A

M

Brain

Invad

ers

Thro

mb

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tograp

hy

11

:00

AM

Lun

ch

12

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PM

Precisio

n

Med

icine

An

aerob

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Bacterio

logy:

Oxygen

Is the

Enem

y

1:0

0 P

M

Mass

Spectro

metry

in th

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ical Lab

Febrile

Transfu

sion

R

eaction

s

Mo

delin

g the

Acad

emic

Bio

repo

sitory

2:1

5 P

M

Ethical

Co

nsid

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Path

olo

gy

3:3

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46

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, 20

17

Re

gistra

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8:0

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Histo

path

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gy

in K

idn

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7

Mu

sic for

Preven

tion

and

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Cases in

Im

mu

no

logy

8:3

0 A

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Taking C

are of

Patien

ts with

Sp

ecial Need

s

RH

Serolo

gical

and

Mo

lecular

Diversity

PSA

Screenin

g C

on

troversies

9:4

5 A

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Mo

lecular

Diagn

ostic

Testing

Overview

of

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therap

y for

Uro

thelial

Carcin

om

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Co

nfigu

ring

the Ep

ic

H.I.S. to

W

ork fo

r the

Labo

ratory

11

:00

AM

Lun

ch

12

:00

PM

Labo

ratory

Hem

atolo

gy C

ellular

An

alysis

Disru

ptive

Beh

aviors in

th

e

Wo

rkplace

1:0

0 P

M

Rap

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Detectio

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f B

acteremia

Transgen

der

10

1

2:1

5 P

M

Neo

nato

logy

& P

atho

logy

3:3

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M

Fifth

An

nu

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ath

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Ed

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47

Lun

ch

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gistra

tion

(Lo

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Thu

rsda

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, 201

7

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gistra

tion

(8a

- 3:3

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8:0

0

AM

Intro

du

ction

to

Bo

ne M

arrow

A

spiratio

n

Hem

olytic

Disease o

f the

Fetus an

d

New

bo

rn

A W

alking (N

ot

Really) To

ur o

f the

D

om

e

8:3

0 A

M

You

're Testing in

Wh

at? A

ntiretro

viral

Dru

g M

easurem

ents

Labo

ratory

Diagn

ostic o

f

Celiac D

isease an

d G

luten

-

related D

isord

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Au

top

sy A

ssemb

led

9:4

5 A

M

Safety Incid

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Rates an

d

Trend

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Path

olo

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Hid

ing in

Plain

Sigh

t: Ho

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Imm

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Reco

gnize an

d

Resp

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d to

Can

cer?

Weird

Micro

Retu

rns:

Wh

at's in YO

UR

Water?

11

:00

AM

Lun

ch

12

:00

PM

Ph

lebo

tom

y

and

Its Im

pact o

n

Labo

ratory

Testing

Essential O

ils

and

Futu

re A

ntib

iotics

Hyp

ervisco-

sity Syn

dro

me

1:0

0 P

M

Telom

ere Len

gth

Testing in

C

linical

Settings

Transgen

der

10

1

2:1

5 P

M

3:3

0 P

M

Fifth

An

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al P

ath

olo

gy

Ed

uc

atio

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l Sy

mp

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Sc

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du

le a

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48

REGISTRATION

Name: ______________________________ Badge #:___________________ Email: _________________________________________________________ JHM Entity: __________________ Division: ___________________________ Supervisor/Manager: _____________________________________________

Selection for the Sessions: Employee: This is a preliminary schedule and is subject to change. To aid us in planning and assigning rooms for each talk, please register at

http://pathology.jhu.edu/department/training/symposium.cfm. You must also register for lunch if you wish to have a lunch available to you only on days you are attending. Registration deadline is September 25, 2017. You may be required to get Supervisor approval before registering.

Are you interested in Volunteering for this event?

http://signup.com/go/PtvQJRG

Examples: Session Moderator, Registration, Room Lead, Lunch, etc.

TUESDAY, OCTOBER 3, 2017

Time Course

8:30-9:30a Music and Medicine 612-409-179:45-10:45a What Have You Done for your Community? 612-404-17 9:45-10:45a Care for the Transgender Patient 612-405-179:45-10:45a Natural Killer (NK) Cells 612-406-1711:00a-12:00p Brain Invaders 612-407-1711:00a-12:00p Thromboelastography 612-408-1712:00-12:45p Lunch 1:00-2:00p Anaerobic Bacteriology 612-410-171:00-2:00p Personalize Medicine 612-411-172:15-3:15p Febrile Transfusion Reactions 612-412-172:15-3:15p Mass Spectrometry 612-413-172:15-3:15p Modeling the Academic Biorepository 612-414-173:30-4:30p Ethical Considerations 612-415-17


http://signup.com/go/sXySEyw

49

REGISTRATION (continued)

WEDNESDAY, OCTOBER 4, 2017

Time Course

8:30-9:30a Cases Seen in Clinical Immunology Lab 612-416-17 8:30-9:30a Music for Prevention and Cure 612-417-17 8:30-9:30a Histopathology in Kidney Disease 612-418-17 9:45-10:45a PSA Screening Controversies 612-419-17 9:45-10:45a RH Serological and Molecular Diversity 612-420-17 9:45-10:45a Taking Care of Patients with Special Needs 612-421-17 11:00a-12:00p Configuring the Epic H.I.S. 612-422-17 11:00a-12:00p Immunotherapy for Urothelial Carcinoma 612-423-17 11:00a-12:00p Path to Molecular Diagnostic Testing 612-424-17 12:00–12:45p Lunch 1:00-2:00p Hematology Cellular Analysis 612-425-17 1:00-2:00p Disruptive Behaviors in the Workplace 612-426-17 2:15-3:15p Rapid Detection of Bacteremia 612-427-17 2:15-3:15p Care for the Transgender Patient 612-405-17 3:30-4:30p Neonatology & Pathology 612-428-17

THURSDAY, OCTOBER 5, 2017

Time Course

8:30-9:30a “Walking Tour” of the Dome 612-429-17 8:30-9:30a Hemolytic Disease of Fetus and Newborn 612-430-17 8:30-9:30a Introduction to Bone Marrow Aspiration 612-431-17 9:45-10:45a Autopsy Assembled 612-432-17 9:45-10:45a Celiac Disease 612-433-17 9:45-10:45a Antiretroviral Drug Measurements 612-434-17 11:00a-12:00p Weird Micro Returns: Water 612-435-17 11:00a-12:00p Hiding in Plain Sight 612-436-17 11:00a-12:00p Safety Incident Rates 612-437-17 12:00–12:45p Lunch 1:00-2:00p Phlebotomy and Its Impact on Lab Testing 612-438-17 1:00-2:00p Essential Oils and Future Antibiotics 612-439-17 1:00-2:00p Hyperviscosity Syndrome 612-440-17 2:15-3:15p Telomere Length Testing 612-441-17 2:15-3:15p Care for the Transgender Patient 612-405-17

Documents

Fifth Annual Pathology Educational Symposiumpathology.jhu.edu/department/training/5thAnnualPathology... · 2017-08-10 · Fifth Annual Pathology Educational Symposium October 3-5,