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FIBROBLAST GROWTH FACTOR-23 AND HYPOVITAMINAEMIA D IN ANAEMIA OF
TYPE 2 DIABETIC NEPHROPATHY
Grigorios G. Dimas1, Fotios S. Iliadis1, Ilias E. Kanellos1, Thomas J. Tegos2, Sofia G. Spiroglou3, Spiros D. Fotiadis1, Ioannis M. Karamouzis1, Christos G Savopoulos1, Apostolos I. Hatzitolios1, Dimitrios M. Grekas1.
1 1st Propaedeutic Medical Department, AHEPA University Hospital, Aristotle University of Thessaloniki, Greece2 1st Neurology Medical Department, AHEPA University Hospital, Aristotle University of Thessaloniki, Greece3 Biochemistry Laboratory, AHEPA University Hospital, Aristotle University of Thessaloniki, Greece
Background
• Clinical and experimental evidence support a role for fibroblast growth factor (FGF-23) in
promoting osteoclastic bone resorption, but the precise molecular mechanisms are not yet
fully understood. FGF-23 has been implicated in chronic kidney disease (CKD) and is
important in humans for osteogenesis.
• The role of vitamin D in type 2 diabetes is well recognized, but its relation to glucose
metabolism is not well studied.
• The observation that anaemia begins in diabetic nephropathy (DN) before the other causes
of CKD leaded us to investigate this hypothesis.
Aim
• The aim of the present study was to determine the serum levels of FGF-23 and
1.25(OH)2D3 and to investigate their potential correlation with anaemia, in early
stages of CKD and type 2 DN.
Methods
• CKD patients of stages 1 and 2 with type II DN (n=50) were included. As controls, there
were healthy individuals (n=40). 1.25(OH)2D3 and FGF-23 levels were measured by an
ELISA method.
Results
• The levels of 1.25(OH)2D3 were significantly higher in patients than in the control groups
(40±3, p<0.0001), FGF-23 were significantly higher in patients (0.5±0.1, p<0.004) and
hemoglobin (Hb) was (4±1, p<0.005). There was negative strong correlation between FGF-23
and 1.25(OH)2D3 (r= -0.75, p<0.005) such as FGF-23 and Hb (r= -0.7, p<0.005).
• There was positive strong correlation between 1.25(OH)2D3 and Hb (r= 0.7, p<0.0001.
Conclusion
• This study suggests that serum levels of FGF-23 and 1.25(OH)2D3 were found to be
independent risk factors of anaemia in early stages of type II diabetic nephropathy.