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Features of the pathways of Ag processing. FeatureClass II MHC PathwayClass I MHC Pathway Composition of MHC Types of APC Responsive T cell Source of Ags Enzymes responsible For peptide degradation Molecules involved in Transport of peptides and Loading of MHC molecules. - PowerPoint PPT Presentation
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Features of the pathways of Ag processingFeatures of the pathways of Ag processingFeatureFeature Class II MHC PathwayClass II MHC Pathway Class I MHC Class I MHC
PathwayPathwayCompositionCompositionof MHCof MHC
Types of APCTypes of APC
Responsive T cellResponsive T cell
Source of AgsSource of Ags
Enzymes responsibleEnzymes responsibleFor peptide degradationFor peptide degradation
Molecules involved inMolecules involved inTransport of peptides andTransport of peptides andLoading of MHC moleculesLoading of MHC molecules
Features of the pathways of Ag processingFeatures of the pathways of Ag processing
FeatureFeature Class II MHC Pathway Class II MHC Pathway Class I MHC Class I MHC PathwayPathway
CompositionComposition alpha/beta chainsalpha/beta chains alpha/beta 2-malpha/beta 2-mof MHCof MHC
Types of APCTypes of APC DC, MO, B cells (endothelial) DC, MO, B cells (endothelial) All nucleatedAll nucleated
Responsive T cellResponsive T cell CD4 T cellsCD4 T cells CD8 T cellsCD8 T cells
Source of AgsSource of Ags ExogenousExogenous EndogenousEndogenous
Enzymes responsibleEnzymes responsible Endosomal and lysosomalEndosomal and lysosomal Cytosolic Cytosolic For peptide degradationFor peptide degradation proteasesproteases proteasomeproteasome
Molecules involved inMolecules involved inTransport of peptides andTransport of peptides and Invariant chain (Ii), HLA-DMInvariant chain (Ii), HLA-DM TAPTAPLoading of MHC moleculesLoading of MHC molecules
Kuby Figure 8-8Viral immune evasion