Featured Pathways & Targets

The Wnt Signaling pathway is heavily involved in both development and disease. It plays a crucial role in det-ermining cell fate during embryonic development, cell migration and proliferation, cellular polarity, apoptosis, and homeostasis. When Wnt signaling goes unregulated it leads to serious consequences during embryonic developm-ent and many pleiotropic human pathologies. Some of these pathologies include breast, colon and skin cancers, skeletal defects, and birth defects, most commonly, spina bifida.

WNT Signaling

TCF

PP2A

GSK3DVL

DVL

APC Axin

β-cateninWTX

β-catenin

β-Trc

UbUb

Ub

TCFHDAC

Groucho

CRE

Cdk

CBP B-caten -

BCL Pyg

RAChib

DVL

CK-1

B-cat -

B-cat -

B-cat -

RAC

DVL

Daa

Rho

RO

RAC

JNK

Prof -

G-pro -

PLC

Wnt

WntLRP5/

Axi

Wnt

LRP5/6

26S proteosome

degradation

WNT target genes

Frizzled

NFAT

path -

cytoskeletal

SFR

DKK

CK-1

GSK3

SFR

WIF

P

PNak

PAR

B-cat -

RAR

ICA

Calci -

NFA

NLK

TAK1

NLK

CamK

PKC

pathway

PKC

Cell survival,

gene expression,

Kinas Phosphatase Ligand Transcription Factor

Other Receptor Phospho Activation

Membrane Cell Function

Binding/Association

Activation Inhibition Indirect Effect

Dissociation

P

TCF WNT target genese: MYC, TCF-1, Cyclin-D1MMP-7,Axin-2,CD44,etc

PP2

GSK3 DVLDVL

APC Axi

B-cat -WT

B-cat -

B-Tvc

UU

U

TCFHD

Grouc

CREB

Cdk

CBP β -caten-

BCL Pyg

RAChib

DVL

CK-1

β-catenin

β-catenin

β-cateni

RAC

DVL

Daam1

Rho

ROCK

RAC

JNK

Proflin

G-protein

PLC

Wnt

WntLRP5/6

Axin

Wnt

LRP5

26S proteo -

some

degradation

WNT

target

genes

Frizzled

NFATpathway

Wnt target genes

cytoskeletal

rearrangement

SFR

DK

GBP

CK-

GSK

SFRP

WIF

P

PNaked

PAR-1

β-cateni

RAR

ICA

Calcineunin

NFAT

NLK

TAK1

NLK

CamKII

PKC pathway

PKC

Cell survival, gene expression,

cytoskeleton arrangement

ONOFF

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GBP

Proliferation,differentiation,adhesion and survival

Ca2+

Ca2+

Ca2+Ca2+

Ca2+