Fatty Acid & Protein Metabolism

Carbohydrate metabolism is WAY groovy baby!

But what does Jon expect us to know from all this

chemistry mumbo jumbo?

Where is Carbohydrate Metabolism?

• Glycolysis ___________________

• Krebs Cycle ___________________

• ETS ___________________

When Is Oxygen Required?

• Glycolysis _________________

• Krebs Cycle _________________

• ETS _________________

What is Produced?

• Glycolysis __________________

• Krebs Cycle __________________

• ETS __________________

Outline

I. Anaerobic Metabolism

II. Fat MetabolismA. Ketoacidosis

B. Diabetes Mellitus

III. Protein Metaboism

Aerobic vs. Anaerobic Respiration

• Only gylcolysis can occur without O2

Aerobic vs. Anaerobic Respiration

• Only gylcolysis can occur without O2

• Anaerobic Metabolism:

1. Inefficient and cannot be sustained for long periods

Anaerobic Metabolism

• Occurs during strenuous exercise

• O2 cannot be delivered to cells fast enough for Krebs Cycle

Outline

I. Anaerobic Metabolism

II. Fat MetabolismA. Ketoacidosis

B. Diabetes Mellitus

III. Protein Metaboism

You Don’t Just Eat Carbohydrates

Big Mac Nutrition Facts:

Calories 500Protein (g) 25Carbohydrates (g) 42Total Fat (g) 26Saturated Fat (g) 16Sodium (mg) 890

You Don’t Just Eat Carbohydrates

Big Mac Nutrition Facts:

Calories 500Protein (g) 25Carbohydrates (g) 42Total Fat (g) 26Saturated Fat (g) 16Sodium (mg) 890

Structure of Triglycerides

Metabolism of Fats

• Fats broken into parts that enter glycolysis and Kreb’s cycle

Metabolism of Fats

• Fats broken into parts that enter glycolysis and Kreb’s cycle

• Fats and Carbohydrates can be stored

You Need Some Carbs to Burn Fat

“Fats Burn in the Fire of Carbohydrate Metabolism”

2 Carbon

6 Carbon4 Carbon

Without Glucose, Ketoacidosis Occurs

Example:Acetone

Metabolic Disorder: Diabetes Mellitus

• Ketoacidosis occurs in Type I Diabetes

Metabolic Disorder: Diabetes Mellitus

• Ketoacidosis occurs in Type I Diabetes

• Lack of insulin causes hyperglycemia

Metabolic Disorder: Diabetes Mellitus

• Ketoacidosis occurs in Type I Diabetes

• Lack of insulin causes hyperglycemia

• Dehydration and sweet taste to urine

Dangers of Ketoacidosis

• Blood pH drops

• Fruity smell to breath

• Diabetic Coma

• Death results

Outline

I. Anaerobic Metabolism

II. Fat MetabolismA. Ketoacidosis

B. Diabetes Mellitus

III. Protein Metabolism

Protein Metabolism

• Last resort for energy

• Why might this be?

Protein Metabolism

• Most is converted into glucose

Protein Metabolism

• Most is converted into glucose

• Some broken down into Urea

Summary

• Carbohydrates, Fats, and proteins are all used for energy (in that order)

• Without oxygen, pyruvate is converted to lactate

• Ketoacidosis occurs in diabetics lacking glucose metabolism