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Derivative and Farmacologycal Activity o

Class Durg class compound

CrinoideaAntioxidant

Crinoidea

Flavonoid

Hollothuroidea

Stichopus japonic Hollothuroidea anti fungal Sapononin

Holothuria Scraba Hollothuroidea antibacterial lectin

Sea cucumber Hollothuroidea Antiinflamsi curcumarirides

Sea cucumber Hollothuroidea Nervous system

Sea star asteroidea Nervous system

asteroidea Nervous system Linckosides F,I,K

asteroidea Phrygiasterol

Hollothuroidea Anti fungal Patagonicoside A

Nickname/Spesies

Comaster Sp (SeaLilies)

eno a ,Flavonoid,alkaloid

Comaster Sp (SeaLilies)

Inflamatoryagent,anticancer,antitumor, antialergic danpreventing of ostheoporosis,anti fungal

Actinopygaagassizi(hollothuroidea), seacucumber

Antineoplastic,anti tumor,antibacterial andantiviral.

Antifungal

SapononinHolothurine A

CEG-3ganglioside, CEG-6 gangliosideLLG-5ganglioside, GP-3ganglioside

Sea star (asterinapectinifera,Linckia laevigata)Starfish (Protierihornemannii)Sea Cucumber (Psoluspatagonicus)

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Echinoidea

asteroidea Anticancer

asteroidea Anticancer

asteroidea Anticancer Phalluside-1

Sea urchin(Anthocidariscrassispina)

Osteogenesisandadipogenesis

Starfish (Nacissiacanariensis)

Ophidiacerebroseides B,C,D

Starfish(Ophidiasterophidiamus)

Ophidiacerebroseides B,C,D

Sea Star(Allostichaster

innaequalis,Cosmasteriaslurida)

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f Marine Echinodermata

Chemistry Origin

[1]

[1]

[2]

[2,3]

[4]

[5]

Glycolipid [5]

ganglioside [5]

Steroid [5]

Sterol [5]

[7]

PharmacologicalActivity

Concentrasion

Reference

non polarcompound

as a stimulantiafor heart,diuretics,hipoglicemicefect

Mixture of severalglicosydes

sitotoxic tosarcoma-180 andadenocarcinoma

2.78-16.7mg/mL.

Mixture of severalglicosydes

Efective toTrichophytonasteroids,Candida albicans

agglutination of bacteria andphagocytosis

efective againtsgram positivebacteria (S.Aureus)

Triterpene-oligoglycosides

Stimulation of Lympocytes andneutrophilsInduction of neurit outgrowth

<10 µM

Induction of neurit outgrowth

<10 µM

Induction of neurit outgrowth

Inhibition of Ca 2+

influx20 µg/ml

triterpeneglycosides

against the fungiCladosporiumfulvum , Fusariumoxysporum andMonilia sp.

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[8]

Glycolipids African [11]

Glycolipids

20 µM

[11]

Extrac of Spindleand gonad

stimulateosteogenesis andadipogenesis onmouse'smesenchymalStem cells(MSCs)

0.2mg/ml or0.5 mg/ml

Inactive plasmacells,astrocytomacellsadenocarcinomacellsInactive plasmacells,astrocytomacellsadenocarcinomacellsGlcospingolipids

(GSL)inactive lungcarcinoma, colon

carcinoma andmelanoma inhuman