Family Secrets Problem Based Learning

Family Secrets

• Part 1: A Family Disease

• Part 2: The Test

• Part 3: A Difficult Choice

• Part 4: Testing for the HD Gene

• Part 5: Making Decisions

Team Roles

Secretary RecorderSpokesperso

n

In Part I, you will

Learn about a family with a history of a genetic disease.

Listen to a short reading.Make lists of Facts and Questions .Practice brainstorming rules.

Class read aloud Part 1:“A Family Disease”

• Listen to reading

• On the sheet provided write Factsthat you know from the reading

• Develop Questions that you have

Family Secrets Part 2, you will

Read another short narrative

List new Facts and Questions

Categorize Questions

Family Secrets

• Groups have 1 minute to go over the case of the Lanahan Family

• What is the dilemma?

Categorize Questions

Risks and

Cause

(RC)

Symptoms

and

Prognosis

(SP)

Diagnosis and

Treatment

(DT)

Family Issues

(not

researchable)

(FI)

Topical Barometer

• If you were Jenny, would you have genetic testing for Huntington’s disease?

• Put your dot on the Topical Barometer continuum.

________________________________________________Definitely Maybe Not Sure Maybe Definitely

Yes Yes No No

Teams organize for research

• Assign each team member a different category of Questions

• Each team member will become a “Category Specialist”

• Write the heading of your category on the Individual Research Log

Jigsaw 1 Category Specialists meet in groups to share

research

Specials go back to their groups and share information

DiagnosisAnd Treatment

FamilyIssuesRisks and Cause

SymptomsAnd

Prognosis

Huntington Gene on chromosome 4

Family SecretsFamily Secrets Part 3 Part 3 A Difficult ChoiceA Difficult Choice

Class read aloud Part 3:Class read aloud Part 3: A Difficult ChoiceA Difficult Choice

Listen to readingListen to reading

Make a List of the FactsMake a List of the Facts

An Ethical Issue An Ethical Issue or Dilemmaor Dilemma

… …..a situation that requires a a situation that requires a decision or decision or anan action that action that involves involves competingcompeting ethicalethical principlesprinciples and and valuesvalues..

Rank each principle in Rank each principle in order of importance to youorder of importance to you

Right to decideRight to decide (Autonomy)(Autonomy)

Do what is bestDo what is best (Beneficence) (Beneficence)

Do no harmDo no harm (Nonmaleficence)(Nonmaleficence)

Do what is fairDo what is fair (Justice) (Justice)

Rank your Rank your “top 3” values“top 3” values

Actions to relieve the suffering of others Actions to relieve the suffering of others CompassionCompassion Keeping a secret Keeping a secret ConfidentialityConfidentiality Keeping a promise; fulfilling an obligation Keeping a promise; fulfilling an obligation FidelityFidelity

Treating others as you would like to beTreating others as you would like to be treated treated Golden RuleGolden Rule

Telling the truthTelling the truth Honesty Honesty Conforming to your own ethical principles/moral values Conforming to your own ethical principles/moral values IntegrityIntegrity

Keeping from public viewKeeping from public view Privacy Privacy Preserving the dignity of self and others Preserving the dignity of self and others Respect Respect

Ethical Decision-Making Process:Ethical Decision-Making Process:By yourselfBy yourself….….

Based on the chart and the Based on the chart and the ethical principles and values ethical principles and values that are important to you….that are important to you….What do What do youyou think is the best think is the best

course of action? course of action?

Modified Topical BarometerModified Topical Barometer#2#2

If you were Jenny, would you have genetic If you were Jenny, would you have genetic testing for Huntington’s disease?testing for Huntington’s disease?

________________________________________________________________________________________________

DefinitelyDefinitely DefinitelyDefinitely Yes NoYes No

Reflection QuestionsReflection Questions

Barometer Conclusions and Conversation:Barometer Conclusions and Conversation:

What conclusions would you make after What conclusions would you make after seeing both Huntington Disease: What is it seeing both Huntington Disease: What is it

Topical Barometers?Topical Barometers?

If you shifted your position on the Topical If you shifted your position on the Topical Barometer, explain why.Barometer, explain why.

HomeworkHomework

Have students read and fill out Have students read and fill out the the Informed Consent FormInformed Consent Form

Part 4: Lab PowerpointPart 4: Lab PowerpointGel ElectrophoresisGel Electrophoresis

Family SecretsFamily Secrets

Copyright © 2004, University of Rochester

Agarose Gel

DNA

DNA and Electrical Current

+

-DNA and Electrical Current

+

-

Part 5 The FuturePart 5 The Future

Fill out the Genetic Testing Laboratory Fill out the Genetic Testing Laboratory Report – discuss resultsReport – discuss results

Read Part 5 ScenarioRead Part 5 Scenario

Discuss the future for the Lanahan FamilyDiscuss the future for the Lanahan Family