Fall Meeting 2014October 9

Life Science Building N 27

October 10 & 11Building O 25, H1 & H4/5

Contact

Funded by the Excellence Initiative of the German federal and state governments (GSC 270 »International Graduate School in Molecular Medicine Ulm«)

Free Child Care Offered

We are offering free on-site child care services for children

ages 0 - 12 during the meeting.

Pre-registration is required till September 30, 2014.

For additional information or to pre-register your child,

please contact Bettina Braun at

Phone: +49 (0) 731/50-36290

E-Mail: bettina.braun@uni-ulm.de

Saturday, October 11th

Session V (O 25, Hörsaal 1) Oncology Chair: Daniel Mertens (Ulm, D)

09:00 - 09:40 T. Berg (Frankfurt, D) Epigenetics in lymphoma - Role of PRC2

09:40 - 10:00 Eva Gentner (IGradU, Ulm) Dissecting the role of the homeobox gene VENTX in normal and malignant hematopoiesis

10:00 - 10:20 Sarah Grasedieck (IGradU, Ulm) The CNS miRNome - evaluating miRNAs as bio-markers for central nervous system diseases

10:20 - 10:40 Kathrin Krowiorz (IGradU, Ulm) Modulation of normal and malignant hematopoi-esis through microRNAs

10:40 - 11:10 Coffee Break and Poster Session

11:10 - 11:30 Julia Richter (IGradU, Ulm) Effects of altered expression and activity levels of CK1δ and ε on tumor growth and survival of colorectal cancer patients

11:30 - 11:50 Edith Schneider (IGradU, Ulm) Hoxa9/Meis1 mediate leukemic programming through microRNA-155

11:50 - 12:30 Jörg Rippmann (Boehringer Ingelheim, D) From RNAi phenotype to molecular antagonists: Development of E3-ligase inhibitors of IDOL

12:30 Closing Remarks

Ulm UniversityInternational Graduate School in Molecular Medicine Ulm

Chairman: Managing Director: Prof. Dr. Michael Kühl PD Dr. Dieter Brockmann

Coordinator: Bettina Braun, Int. Dipl. Betriebswirtin

E-Mail: bettina.braun@uni-ulm.de

Albert-Einstein-Allee 11, O 25 425 | D-89081 Ulm

Phone: +49 (0) 731/50-36290 | Fax: +49 (0) 731/50-36292

www.uni-ulm.de/mm

14:30 - 14:50 Ramona Kratzer (IGradU, Ulm) Transgene- and capsid-based modifications of adenovirus gene transfer vectors for genetic vaccination

14:50 - 15:10 Lea Krutzke (IGradU, Ulm) Adenovirus capsid modifications to understand and manipulate vector-blood interactions

15:10 - 15:30 Coffee Break and Poster Session

15:30 - 15:50 Edina Lump (IGradU, Ulm) Effect of the molecular tweezer CLR01 on viral infection

15:50 - 16:10 Katharina Mack (IGradU, Ulm) HIV-1 group O has evolved Nef as an antagonist of the antiviral factor tetherin

16:10 - 16:30 Katharina Mohr (IGradU, Ulm) Generation and characterization of CXCR4 mutants associated with WHIM syndrome

16:30 - 16:50 Janis Müller (IGradU, Ulm) SEVI and semen prolong HIV-1 particle infectivity

16:50 - 17:30 Philip Ng (Houston, USA) Helper-dependent adenoviral vectors; Applications in gene and cell therapy

17:30 Poster Session

International Graduate School

in Molecular Medicine

Ulm

B 10

H

H

H

HH

H

H

Hochschule Eselsberg 3, 5

Wilhelm-Runge-Str.3, 5, 45

Univ. West3, 5, 45

KlinikenWissenschafts-stadt3, 5, 45

Staudingerstr.3, 5, 45

BotanischerGarten3, 5, 15, 45

Univ. Süd3, 5, 6, 13, 15, 45O22

O23N22 N23N24

N25N26

O25O26 O27 O28

M23 M24M25 N27

Wilhelm

-Runge-Str.

Berliner R

ing

Berliner Ring

Albert-Einstein-Allee

Mähringer Weg

J.-Franck-Ring

Helmholtzstraße

Lehrer-Tal-Weg

Albert-Einstein-Allee

Meyerhofstr.

Oberer Eselsberg

Staudingerstr.

Lise

-Mei

tner

-Str

.

Hochschule

UniversitätBereich West

Science Park II

Science Park I

Daimler AG

Versorgungs-anlage

SportzentrumUlm Nord

Botanischer Garten

UniversitätsklinikumOberer Eselsberg

RichtungStuttgart/MünchenAutobahn A7/A8Ausfahrt Ulm West

Richtung UlmStadtmitte

RichtungJungingen

Universitäts-verwaltung

Freigelände

Gewächs-häuser

Bibliotheks-Zentrale

Keine Durchfahrt zur Universität!

Chirurgie

UniversitätBereich OstInnere Medizin

Bundeswehr-krankenhaus

Rehabilitations-krankenhaus

Life Science Building N27

ParkhausHelmholtzstraße

ParkhausAlbert-Einstein-Allee P

P

For visitors it is recommended to park in the red marked car parks.

Thursday, October 9th

Friday, October 10th

Session I und II parallel in Building O 25

Session I (O 25, Hörsaal 4/5) Neurobiology I Chair: Anke Witting (Ulm, D)

08:30 - 09:10 Flaviano Giorgini (Leicester, UK) Targeting neuroprotective strategies in Huntington’s disease

09:10 - 09:30 Hanna Bayer (IGradU, Ulm) Effect of ALS related genes on the PGC-1 α signaling system

09:30 - 09:50 Simon Breitenbach (IGradU, Ulm) Modulation of muscular membrane potential by aldosterone antagonist eplerenone

09:50 - 10:10 Corinna Bliederhäuser (IGradU, Ulm) Age dependent defects in monocytic and microgli-al phagocytosis of alpha Synuclein oligomers

10:10 - 10:30 Coffee Break and Poster Session

10:30 - 10:50 Resham Chhabra (IGradU, Ulm) Delivery of bioactive substances into the CNS using nanomedical approaches for the treatment of synaptopathies

10:50 - 11:10 Anna Speidel (IGradU, Ulm) Neuronal cell culture models derived from induced pluripotent stem cells to study effects of mutant LRRK2

11:10 - 11:30 Sonja Halbedl (IGradU, Ulm) Characterization of ProSAP1/Shank2 function in development and disease

11:30 - 11:50 Pascal Lösing (IGradU, Ulm) The role of SRF (Serum Response Factor) in a murine model of epilepsy

11:50 - 12:30 Cedric Raoul (Montpellier, F) The contribution of neuroinflammation in motoneuron disorders

Session II (O 25, Hörsaal 1) Cell Biology Chair: Steffen Just (Ulm, D)

08:30 - 09:10 Christoph Englert (Jena, D) The Wilms tumor protein Wt1 acts in different places: from the kidney to the CNS

09:10 - 09:30 Naseebullah Kakar (IGradU, Ulm) Identification of genes responsible for recessive monogenic disorders

09:30 - 09:50 Julia Kemmler (IGradU, Ulm) Modulation of post-traumatic inflammation and fracture healing by oxygen treatment

09:50 - 10:10 Patricia Klöble (IGradU, Ulm) The role of SHARP/Mint as an epigenetic regulator of tissue repair and aging

10:10 - 10:30 Coffee Break and Poster Session

Multimedia Room, Life Science Building

17:00 Opening Ceremony

Tobias Böckers (Ulm, D)

Philip Wong (Baltimore, USA) Alzheimer’s Disease: Lessons from animal models

Graduation Ceremony

Student Award

Come-Together-Party

10:30 - 10:50 Katarzyna Krzemien (IGradU, Ulm) Structure of nucleosomal arrays towards super-resolution fluorescence studie

10:50 - 11:10 Steven Rudeck (IGradU, Ulm) The misfolded myosin response in health and disease

11:10 - 11:30 Julia Segert (IGradU, Ulm) Zebrafish as a model for heart valve develop-ment and heart muscle diseases

11:30 - 11:50 Rüstem Yilmaz (IGradU, Ulm) Characterization of UBE3B, a ubiquitin ligase mutated in Kaufman oculocerebrofacial syn-drome

11:50 - 12:30 Marco Sandri (Padua, I) Mitochondrial shaping proteins and the control of protein synthesis and degradation

12:30 - 13:30 Lunch Break (Hörsaal 7)

Session III und IV parallel in Building O 25

Session III (O 25, Hörsaal 4/5) Neurobiology II Chair: Karin Danzer (Ulm, D)

13:30 - 14:10 Albrecht M. Clement (Mainz, D) Mutant SOD1-toxicity in ALS: from soluble pro-teins to aggregate formation

14:10 - 14:30 Nicolai Marroquin (IGradU, Ulm) Molecular analysis of different repeat polymor-phisms and novel mutations in amyotrophic lateral sclerosis (ALS)

14:30 - 14:50 Marina Nagler (IGradU, Ulm) Cannabinoid CB2 receptor modulates the dy-nein light chain protein Tctex-1 and influences cell cycle control

14:50 – 15:10 Noemi Pasquarelli (IGradU, Ulm) Pharmacological inhibition of monoacylglycerol lipase as a therapeutic strategy for neurodege-nerative diseases

15:10 - 15:30 Coffee Break and Poster Session

15:30 - 15:50 Christine Schurr (IGradU, Ulm) The role of neuroinflammation in the onset and progression of amyotrophic lateral sclerosis

15:50 - 16:10 Nadine Sowada (IGradU, Ulm) Functional involvment of the monogenic Parkinson disease gene VPS35 in heavy metal homeostasis

16:10 - 16:30 Marisa Feiler (IGradU, Ulm) Development and characterization of a TDP-43 oligomerization assay and studying TDP-43 transmission

16:30 - 16:50 Lisa Zondler (IGradU, Ulm) The contribution of different monocyte sub-populations to ALS

16:50 - 17:30 Ana Martin-Villalba (Heidelberg, D) Contribution of peripheral innate response to neurodegeneration

Session IV (O 25, Hörsaal 1) From viruses to gene therapy Chair: Florian Kreppel (Ulm, D)

13:30 - 14:10 Aloys Schepers (Munich, D) Progress of EBNA1/oriP-based vectors and its derivatives in gene therapy

14:10 - 14:30 Stephanie Kallert (IGradU, Ulm) Design and evaluation of strategies to optimize Lipid-specific T-cell responses against myco-bacterium tuberculosis

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