Faculty of Pathology 37th Annual Symposium &

Annual General Meeting

Thursday 7th & Friday 8th February 2019 Approved for up to 8 CPD credits

Thursday 7th February 2019 (5 CPD)

9.30-10:00 Registration / Stand viewing

10:00 -10:15 Dean’s Address

Session 1

10:15 - 13:00 Breakout Sessions

Corrigan Hall Lecture Theatre

HISTOPATHOLOGY

Cancer biomarkers

Chairs: Dr Clive Kilgallen,

Dr Cynthia Heffron

MICROBIOLOGY/HAEMATOLOGY/

CHEMICAL PATHOLOGY/IMMUNOLOGY

Critical care and Sepsis

Chairs: Dr Una Ni Riain, Dr Ronan

Desmond

Title/ Time Speaker

Title/ Time Speaker

10:15- 10:45

PDL-1

Immunohisto-

chemistry in lung

cancer and

melanoma

Professor Aurelie

Fabre,

Consultant

Histopathologist

and UCD Clinical

Professor

10.20- 10.55

The Surviving

Sepsis

Guidelines

Seem to Work

– but at what

cost?

Dr Patrick Neligan,

Consultant Anaesthetist,

Galway University Hospitals

10.45- 11.15

Great Advances in

Pathology and

Implications for the

real life Oncologist

Dr Deirdre

O’Mahony,

Consultant Medical

Oncologist, Cork

University Hospital

10.55- 11.30

New

diagnostics in

infection in

ICU patients

Dr Claire P Thomas,

Consultant Infectious

Diseases/

Clinical Microbiology,

Hampshire hospitals NHS

Foundation Trust

11.15-11.45

NGS Platforms

Dr Bruce Moran,

St. Vincent's

University Hospital,

Cancer Biology &

Therapeutics

Laboratory, Conway

Institute

11.30- 12.05

Coagulation

Crosstalk

Dr Ruth Gilmore,

Consultant Haematologist,

Galway University Hospitals

11.45-12.30

Keynote Lecture:

Molecular

Biomarkers in

Colorectal Cancer

Professor Phil

Quirke,

Head of Tumour

Biology and

Pathology,

University of Leeds

12.05- 12.40

Immunology

in the

Critically Ill

patient

Dr Tom Ryan,

Consultant in Anaesthesia &

Intensive Care, St James’s

Hospital, Dublin

12.30- 13.00

Histopathology EQA

12.40- 13.00

Questions

13.00- 14.00 Lunch / Poster & Stand viewing

Session 2: General Chair: Dr Joan Power

Time Title Speaker

14:00-14:20

Whither Pathology? Engagement, Recruitment &

Medical Education

Prof Hilary Humphreys, Professor of Clinical

Microbiology, RCSI and Consultant Microbiologist,

Beaumont Hospital

14:20-14:50

Keynote Lecture: The role of behavioral drivers in the delivery of healthcare in Europe

Prof Michael Borg, Head of Departments of Infection Control & Sterile Services, Mater Dei Hospital, Malta

14:50-15:05

Presentation of the George Greene Medal Winner ‘FISH studies in DLBCL: correlations with cell of origin: the Irish Experience.’

Dr Deirdre Timlin

15:10-15:25

Presentation of the John D Kennedy Medal Winner ‘Back to the future: routine morphological assessment of the tumour microenvironment is prognostic in stage II/III colon cancer in a large population-based study.’

Dr Sean Hynes

15:25- 16:25

Rapid fire poster session

Chairs: Dr Una NiRiain, Dr Cynthia Heffron

16:25-16:40

Announcement of the Winners of the poster, Rapid Fire poster session and student poster prize. Close out.

19.00 Admissions Ceremony

20.00 Dinner

Friday 8th February (3 CPD)

Time Title Speaker

9.00-10.30 AGM

General Session

Chairs: Dr Pat Twomey, Dr Aurelie Fabre

10:30- 11:00 Molecular Pathology: Applications in Solid Tumours

Dr Brendan Doyle, Department of Histopathology Beaumont Hospital

11:00- 11:30 Whole Genome sequencing and its application in diagnosis/typing of Enterobacterales including CPE

Prof Martin Cormican, National Clinical Lead for HCAI and AMR. Professor of Bacteriology, NUI Galway. Consultant Microbiologist, Galway University Hospitals.

11:30-11:45 Coffee

11:45- 12:15 Molecular techniques in

lymphoma malignancies

Prof Elisabeth Vandenberghe,

Consultant Haematologist, St James’s

Hospital, Dublin

12:15- 12:45 Genetics of Familial

Hypercholestrolaemia

Dr Vivion Crowley, Consultant Chemical

Pathologist, St James Hospital, Dublin

12:45- 13:15 The Liquid Biopsy: Circulating

tumour DNA for lung cancer

management. Promises &

Pitfalls

Dr Stephen Finn, Consultant Pathologist,

St. James's Hospital

13:15- 13:30 General Discussion and Q&A

13.30 Closing Address from Dean Prof Louise Burke,

Department of Histopathology

Cork University Hospital

Guest Speaker Biographies

Prof Aurelie Fabre Prof Aurelie Fabre is a Consultant Histopathologist, and UCD Clinical

Professor at the Department of Histopathology, St Vincent's University

Hospital, Dublin, with a special interest in Thoracic Pathology.

She is also the Heart and Lung Transplant Pathologist of the National

Transplant Unit at the Mater Misericordiae University Hospital.

She is the Lead in Pulmonary Pathology and runs/participate ate weekly

MDTs, cancer and non-cancer including interstitial lung diseases.

She graduated from Trinity College Dublin in 1996, then got a Master in

Medical Sciences in Pathology at University College Dublin in 1998 and

went on to train in Histopathology in Paris and in London, and got my

MRCPath in 2002.

She then completed a PhD thesis on the pathogenesis of lung fibrosis in

parallel to a Fellowship in Thoracic Pathology at Bichat Hospital, Paris in

2007 and 2012. Her main interests include interstitial lung diseases,

lung cancer, heart and lung transplant pathology, and

cardiac/cardiovascular pathology. She has developed diagnostic and

predictive profiling of lung cancer in the department and have

facilitated the implementation of PD-L1 testing in non small cell lung

cancer in Ireland. At research levels, she provide expertise in tissue and

cell morphology, image analysis, animal models and

immunohistochemistry. She is the founder/Director of the Research

Pathology Core technology at the Conway integrating Research

Immunohistochemistry and Digital Pathology

http://www.ucd.ie/conway/research/coretechnologies/researchpathologycore/

Dr Patrick Neligan

Patrick Neligan is a Consultant Anaesthetist and Intensive Care Medical

Director at Galway University Hospitals, and Honorary Professor of

Anaesthesia and Intensive Care at National University of Ireland,

Galway. He trained in medicine and anaesthesia in Ireland, and did his

critical care training in the USA at Duke University and University of

Pennsylvania, where he was on staff from 2002-2008. He is co-editor of

“An Evidence Based Practice of Critical Care –now in its third edition.”

Dr Deirdre O’Mahony

Dr Deirdre O’Mahony is a UCC graduate. She undertook her Medical

Oncology training in Beaumont and St James’s Hospitals in Dublin, in

addition to completing a Masters in Molecular medicine from Trinity

College Dublin in 2002. She completed a post graduate fellowship in the

National Cancer Institute in Bethesda, Maryland. She continued there as

a Consultant, continuing her research into viral associated malignancies.

In 2008, she returned to St James’ Hospital, Dublin specializing in virally

associated malignancies, lymphoma, sarcoma and Head and Neck

Cancer. She is a long-standing member of the Lymphoma Forum of

Ireland and co-founded the Irish Sarcoma Group. She moved to serve

the Cork / Kerry region in 2012; specialty interests in Breast, Lymphoma

and Sarcoma. She has been active in clinical, academic and research

programs. She is the president of the Irish Society of Medical Oncology

and committee member of the ASCO International Quality Task Force

(IQTF).

Dr Claire Thomas

Dr Claire Thomas trained at Oxford and St Bartholomews hospital in

London. She gained her PhD in virology, in Oxford, and trained in

InfectiousDiseases and clinical Microbiology at Impeial. She has worked

as a consultant in Imperial, Singapore General Hospital, and currently is

Director of Infection control, at hampshire Hospitals NHS Trust UK. Her

research interests are Antibiotic resistance, rapid diagnostics, and their

role in patient safety and outcomes.

Dr Bruce Moran

Bruce Moran is a bioinformatician with the Ireland East Hospital Group

working in the Department of Histopathology, St. Vincent’s University

Hospital. His general interest is in the use of ‘next-generation’

sequencing data to investigate the molecular basis of cancer. This is of

use in both clinical and research settings: in the former as a diagnostic

utility, the latter to understand disease occurrence and progression.

Current projects include ongoing patient exome analyses. This is applied

in diagnostically challenging cases and involves sequencing all protein-

coding regions of the genome which can then be assessed for

potentially cancer-related variants. This is particularly useful when ‘non-

canonical’ variants in known oncogenes are not found by standard

diagnostic molecular methods. It also allows molecular characterisation

of metastases and recurrences. From an analysis standpoint, he is very

interested in the reproducibility of data analysis and in transparency of

scientific methods.

Dr Ruth Gilmore

Dr Ruth Gilmore graduated from NUIG in 1998. She completed her

Higher Specialist Training in Haematology in 2007 and completed an MD

in thrombin generation in 2009. Her main areas of interest include

Haemostasis and Thrombosis, Obstetric Haematology and Paediatric

Haematology. She returned to Galway as a Consultant Haematologist in

2011 where she practises as a Coagulation Specialist.

Professor Phil Quirke BM, PhD, FRCPath, FMedSci, FRCSEd (ad hominem) Is the Yorkshire Cancer Research Centenary Professor of Pathology in the School of Medicine at the University of Leeds, UK and honorary Consultant Pathologist, Leeds Teaching Hospitals NHS Trust. He leads the section of pathology and tumour biology in the University of Leeds and has a major research interest in Bowel cancer, molecular and digital pathology and postgraduate academic education. Honorary Fellow/ honorary member of six international surgical societies and Fellow of the Academy of Medical Sciences, UK. Phil’s major achievements have been: To identify the cause of local recurrence in rectal cancer and open up the way to minimise this occurrence. To show that simple observations of anatomy and cancer surgery and the specimens that are removed by surgeons can identify the quality of the operating surgeon and that educational interventions using excellent surgeons can improve outcomes in a number of countries. With Gina Brown contributed to evaluation of the value of MRI imaging in rectal cancer. Pathology, molecular ad digital pathology contributions to the QUASAR, CLASICC, CR07, ROLARR, FOCUS1-4, FOXTROT, TREC and many other clinical trials. Leads the Pathology of the English Bowel Cancer Screening programme since 2006 and coordinated the Pathology chapter of the European guidelines on bowel cancer screening. Newer areas of work: Identifying variations in clinical practice and the use of big data to understand multidisciplinary team clinical results and improve outcomes with Professor Eva Morris. Exploration of the impact of the microbiome on causation, screening and treatment of colorectal cancer.

Dr Tom Ryan Dr Ryan has been a Consultant in Intensive Care and Anesthesia since 1997. He began his training in Ireland, followed by sub-specialty training at the University of Washington in the US. He undertook additional Intensive Care and Anesthesia training at the Mayo Clinic in Minnesota and was a consultant in the Cleveland Clinic, before returning to Ireland to his position in St. James’s Hospital.

Prof Hilary Humphreys Hilary Humphreys is Professor of Clinical Microbiology at the RCSI and Consultant Microbiologist at Beaumont Hospital Dublin. He has been Dean of the Faculty of Pathology at the RCPI since 2016, has a longstanding commitment to medical education and training, and he has a particular professional and research interest in hospital infections. In November 2018, he became President of the Healthcare infection Society

Prof. Michael Borg

A clinical microbiologist by training, Prof. Michael A. Borg heads the

Department of Infection Prevention and Control at Mater Dei Hospital

in Malta and chairs the country’s National Antibiotic Committee. He is a

past president of the International Federation of Infection Control (IFIC)

and has an expert to the European Centre for Disease Control (ECDC) on

the prevention & control of healthcare associated infections and the

prudent use of antimicrobial agents in human medicine.

Michael has been involved in several EU funded projects on the

epidemiology of antimicrobial resistance, prevention and control of

healthcare associated infections and antibiotic use within Europe and

the Mediterranean region. He has authored or collaborated in more

than 80 publications on these subjects within peer reviewed journals.

His latest research interests focus especially on human behaviour and

change management and their role in infection prevention and control

as well as antibiotic stewardship.

Dr Brendan Doyle

Brendan graduated Trinity College, Dublin in 2003 with a degree in

medicine. He trained in histopathology in Dublin, the Brigham and

Women's Hospital, Boston and in the Beatson Institute for Cancer

Research in Glasgow, where he received a PhD in Molecular Pathology

and Cancer Studies from the University of Glasgow. He worked as a

lecturer in Trinity College before taking up his current post as a

consultant pathologist in Beaumont Hospital. He has a particular

interest in molecular pathology as it applies to personalised medicine

and is the clinical lead for solid tumour molecular diagnostics in

Beaumont/RCSI.

In addition to his clinical/diagnostic work he has published original

research papers, review articles and a book chapter in the area of

molecular pathology. He has received international awards from the

Pathological Society of Great Britain and Ireland and the US and

Canadian Association of Pathology for his work.

Prof Martin Cormican

Graduated from NUI Galway 1986. Trained in Ireland, UK and USA.

Appointed Consultant Microbiologist GUH and Professor of Bacteriology

NUI Galway in 1999. Since May 2017 – National Lead for Healthcare

Associated Infection and Antimicrobial Resistance. Research interests

are antimicrobial resistance, foodborne infection and the links between

environment and human health.

Professor Elisabeth Vandenberghe

Professor Elisabeth Vandenberghe qualified from University College

Dublin, and initially trained in Ireland before working on the genetic

characterization of Mantle Cell Lymphoma at the University of Leuven

(KUL) in Belgium for which she was awarded a PhD, before moving to

University College London Hospital to complete specialist training in

haematology. She worked briefly at Sheffield Trust Hospitals, setting up

a haematology molecular diagnostics service and leading the bone

marrow transplantation service before returning to St James Hospital

and Trinity College Dublin in 2002 where she is currently lymphoma

clinical lead and co-director of the Cancer Molecular Diagnostics

Department. She sits on a number of European committees including

the lymphoma working party of the European Bone Marrow

Transplantation group, European Research Initiative on CLL and the

European Mantle Cell Lymphoma group and has co-authored over 80

articles, mainly on the diagnosis and management of lymphoid

malignancies

Dr Vivion Crowley

Dr Vivion Crowley is a graduate of University College Cork Medical

School and is Consultant Chemical Pathologist and Head of the

Biochemistry Department in St James’s Hospital, Dublin. He trained in

Chemical Pathology in Dublin, Manchester and Cambridge, where he

also obtained a Wellcome Trust Research Training Fellowship,

undertaking research into the genetics of obesity and diabetes with Prof

Sir Stephen O’Rahilly in the Department of Clinical Biochemistry,

Cambridge University. He was subsequently appointed as a Consultant

Chemical Pathologist in Addenbrooke’s and Hinchingbrook Hospitals,

Cambridge, before taking up his current post in 2004. He has a specific

interest in clinical and laboratory diagnostic aspects of acute porphyrias

and genetic dyslipidaemias. He is the current National Speciality

Director in Chemical Pathology.

Professor Stephen Finn

Professor Stephen Finn is a consultant pathologist at St. James’s

Hospital and Associate Professor of Pathology at the University of

Dublin, Trinity College Dublin. Dr. Finn is Co-Director of the Cancer

Molecular Diagnostics Laboratory at St. James’s and has subspecialist

expertise in cancer molecular diagnostics of solid tumours. Dr. Finn

qualified from University College, Cork (UCC) in 1998, completed his

higher professional training in histopathology in 2005 and subsequently

worked as staff pathologist and Senior Scientist at the Centre for

Molecular Oncologic Pathology (CMOP) at the Dana Farber Cancer

Institute in Boston, USA. He returned to Ireland in 2008 and worked as

Consultant pathologist at the Mid Western Regional Hospital Limerick

before moving to his current position.

His PhD is from Trinity College Dublin (2005) and he is a Fellow of the

Royal College of Pathologists, UK. Dr. Finn is a member of the European

Thoracic Oncology Platform (ETOP) and leads the thoracic oncology

research group at St. James’s Hospital, Dublin. Dr. Finn’s primary

research interests are focused on lung and prostate cancers, including

obesity and metabolic syndrome in prostate cancer progression, the

molecular significance of dietary and exercise interventions, noncoding

RNA signatures of advanced prostate cancer, circular RNAs as

biomarkers and the utility of circulating DNA and Circulating Tumor Cells

as a liquid biopsy. In addition, Dr. Finn has interests relating to human

cancer molecular diagnostics particularly in relation to the use of Next

Generation Sequencing for routine molecular diagnostics.

This event has been supported by way of unrestricted educational grants from:

GOLD Sponsors:

SILVER Sponsors:

NOTES: