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Faculty of Medicine
21 M.K. Čiurlionio, LT-03101 Vilnius
Tel. 239 8700, fax 239 8705
E-mail: [email protected]
www: http://www.mf.vu.lt
Dean – Prof. Habil. Dr. Algirdas Utkus
STAFF
416 teachers (279 holding research degree), 87 research fellows (53 holding research degree),
113 doctoral students (Medicine – 102; Public Health – 11)
DEPARTMENTS OF THE FACULTY
Clinic of Obstetrics and Gynaecology
Department of Anatomy, Histology and Anthropology
Clinic of Anaesthesiology and Reanimatology
Clinic of Ear, Nose, Throat and Eyes diseases
Department of Physiology, Biochemistry, Microbiology and Laboratory Medicine
Gastroenterology, Nephrourology and Surgery clinic
Clinic of Infectious, Chest diseases, Dermatovenereology and Allergology
Neurology and Neurosurgery clinic
Institute of Odontology
Department of Pathology, Forensic Medicine and Pharmacology
Clinic of Psychiatry
Department of Radiology, Nuclear Medicine and Physics of Medicine
Department of Rehabilitation, Physical and Sports Medicine
Clinic of Rheumatology, Orthopaedic and Traumatology and Reconstructive Surgery
Department of Nursing and Fundamentals of Internal Medicine
Clinic of Cardiovascular diseases
Clinic of Internal Medicine, Family Practice and Oncology
Institute of Public Health
Department of Human and Medical Genetics
RESEARCH AREAS
Human genome diversity, its origin and phenotypic realization
Human and public health, quality of life and environment
Etiopathogenesis, diagnostics, treatment of diseases: fundamental and clinical research,
innovative technologies.
DOCTORAL DISSERTATIONS MAINTAINED IN 2015
L. Rimševičius. Prevalence of early stages of chronic kidney disease and its associations with
cardiovascular risk factors in a cohort of patients at high cardiovascular risk
D. Vajauskas. Cardiac adrenergic innervation imaging for prediction of heart failure.
A.Vilionskis. Predicting outcome of intravenous thrombolysis for acute ischemic stroke
V.V. Maneikienė. Cardiac Resynchronization Therapy: evaluation and prediction of
effectiveness
A. Šidlauskienė. Relationships between Functional Fitness and Physical Activity in Early
Adolescence
J. Stasiūnienė. Newborn murder: medical, social, legal insights, their analysis and evaluation.
I.Šatinskienė. Treatment of sudden sensorineural hearing loss with corticosteroids and
assessment of anatomical changes in the middle ear
D. Bužinskienė. Peri-anal diseases in pregnancy and after childbirth: incidence, risk factors
and impact on woman‘s quality of life.
P. Kalesinskas. Inhibition of dental biofilm formation using antisense oligonucleotide to
bacterial glucosyltransferases
V. Banys. Evaluation of new platelets and inflammatory biomarkers’ value in the
pathogenesis of atherosclerosis and metabolic syndrome
A.Žalnora. Development of public health science at the Stephen Bathory Uuniversity and
public health conditions in the Vilnius province in the years of 1919 – 1939
E. Danielienė. Corneal Ablation with Femtosecond Ultraviolet Pulses
A. Gaižauskas. The comparative study of effectiveness and risk factors of ureteroscopy and
extracorporeal shock wave lithotripsy in the upper part of ureter
E. Uždavinytė Gatelienė. Outcome predictors and clinical results of surgical treatment in
patients with coronary artery disease, mitral regurgitation and left ventricular dysfunction
G. Kvederas. Comparison of three tourniquet application methods in primary total knee
arthroplasty surgery
S. Burokienė. Pre-hospital paediatric healthcare services in emergency departments:
perspectives for optimisation
L. Daukantienė. Influence of molecular and genetics factors of the organism's antioxidative
system on cervical carcinogenesis and the role of these factors in treatment of locally
advanced cervical cancer
R. Ivaškevičius. Pertussis in the most vulnerable age groups of children in the major cities of
Lithuania
V. Bilius. The timing of surgery for cryptorchidism and fertility prediction based on the
evaluation of spermatogenesis in testicular biopsies
A. Brazaitis. Comparative analysis of knee joint static and kinematic magnetic resonance
imaging and its value to the diagnostics of patellofemoral stress sindrome.
A.Karpavičius. The value of inflammation markers in early acute pancreatitis course
prediction: the results of prospective multicenter cohort study.
A. Navickienė. The evaluation of revascularization methods for tibial arteries in patients with
diabetes
I. Arštikytė. Biologic therapy in patients with autoimmune arthritis
V. Beleškienė. The effectiveness of the laser eustachian tuboplasty for chronic secretory otitis
I. Vaišnorienė. In vivo reflectance confocal microscopy study to identify dysplasia of
melanocytic nevus
N. Kuprevičienė. Epidemiological patterns of diphtheria in Lithuania in 1991-2011 and its
prevention
MAIN CONFERENCES ORGANIZED IN 2015
1. International conference Prenatal, genetic and preimplantation diagnostics
2. International conference Prenatal medicine and gynecology: present and future
3. Annual international congress Role of laboratory medicine in managing chronic
diseases
4. International conference Complete blood count – current topics
5. International conference Immunohaematology and testing of blood components –
solutions and newest scientific tendencies
6. International conference Relevant issues of contemporary medicine
7. International Conference 17th annual meeting of Lithuanian Society of
Cardiothoracic Surgery
8. International conference Epilepsy Diagnosis: Roads and Deadlocks
9. International conference 13th
Baltic Neurosurgery Association Meeting
10. International conference Prevention of complications in prosthetic dentistry
11. International conference Perspectives of modern otology and otosurgery
12. The 8th Baltic Morphology Scientific Conference: Interdisciplinary Nature of
Contemporary Morphology
13. International conference Radiology 2015
14. International conference Books in Group Analysis
15. International conference Genetic in Psychiatry
16. 7th European Regional Conference on Thoracic Oncology
17. IV conference of World Rare Disease Day Lysosomal Storage Disorders
18. XX Vilnius International Paediatric Pulmonology and Alergology Conference-School
19. Vilnius Course 2015
20. International Seminar Ethics of HIV research
21. Seminar Advanced Certificate Program: Research Ethics in Central and Eastern
Europe, http://bioethics.uniongraduatecollege.edu/nih-grant/about
22. Conference Dysmorphology Autumn 2015
23. Conference of the LITGEN project
Local conferences
1. National conference Noveltys in otorhinolaryngology
2. National conference Relevant ophthalmological problems in pediatric patients and
adults
3. Conference Endocrine disease diagnosis and treatment news
4. Conference Thrombophilia and hypercoagulation disorders
5. Conference Nursing Science and Practice 2015
6. Conference Nursing Research and Practice Problems
7. 9th Baltic conference Family Medicine 2015
8. Conference Autumn of Pulmonology and Allergology 2015
9. Conference Experience of professionals in their daily work in primary health care
10. National conference Rare Diseases Day
11. National conference Down Syndrome Day
MAIN SCIENTIFIC ACHIEVEMENTS IN 2015
An overview about types and frequencies of CT procedures and estimation of the average
dose length product (DLP) values for commonly performed adult CT examinations (head,
chest, abdomen and pelvis) comparing two different scaners. Scientific research presented in
12th International Conference “Medical Physics in the Baltic States 2015”.
Vilnius University has one of the largest experience in the world of new minimally invasive
transapical beating-heart neochord implantation for treatment of degenerative mitral valve
incompetence. This is a new alternative for conventional mitral valve repair in selected
patients. Many teams from European cardiac surgery centers have visited Vilnius University
for training of this new technique. The experience of two centers with largest experience of
transapical neochord implantation has been summarized in common publication with Italian
colleagues Colli A., Manzan E., Rucinskas K., Janusauskas V., Zucchetta F., Zakarkaite D.,
Aidietis A., Gerosa G. Acute safety and efficacy of the NeoChord procedure.
Interactive Cardiovascular and Thoracic Surgery 2015, 20(5):575-581.
CLINIC OF OBSTETRICS AND GYNECOLOGY
Santariškių g. 2, 08661 Vilnius
Tel./fax 8 5 2501484; 8 5 2501487
E-mail [email protected]
Head – Prof. Dr. HP Gražina Stanislava Drąsutienė
STAFF
Professors: Dr. HP G. S. Drąsutienė, Dr. N. Drazdienė
Associate professors: Dr. J. Ališauskas, Dr. A. Arlauskienė, Dr. D. Bartkevičienė, Dr. Ž.
Bumbulienė, Dr. D. Laužikienė, Dr. D. Ramašauskaitė, Dr. M. Šilkūnas, Dr. J. Zakarevičienė
Lecturers: Dr. G. Domža, Dr. V Rudaitis
Assistants: A. Amšiejienė, V. Paliulytė, I. Daunoravičienė, T. Lūža, D. Bužinskienė, V.
Sniečkuvienė.
Doctoral students: A. Amšiejienė, Ž. Sabonytė-Balšaitienė
RESEARCH INTERESTS
Health of mother and fetus: physiology and pathology
RESEARCH PROJECTS CARRIED OUT IN 2015
Project Supported by University Budget
Health of mother and fetus: physiology and pathology. Prof. Dr. HP G. S. Drąsutienė,
2014-2018
Uterine and ovarian sizes in adolescents with functional hypothalamic amenorrhoea (FHA)
were estimated and compared with findings in peers having regular menstrual cycles. In
adolescents with FHA the dimensions of uterus and ovaries were smaller than in girls having
regular menstrual cycles. Oestrogen deficiency causes a reduction in uterine size. Uterine size
and ovarian size correlate positively with BMI.
The experiences of community pharmacists in advising pregnant women at Lithuanian
community pharmacies were explored. Improving the physician-pharmacist-patient
communication environment and providing education and training programmes for
pharmacists are necessary to reduce stress and to overcome barriers in advising pregnant
women.
Risk factors for peri-anal diseases in pregnancy, during delivery and after childbirth were
explored: constipation during pregnancy, peri-anal diseases during previous pregnancy and
childbirth; instrumental mode of delivery, straining duration; indicators of a newborn’s
physical condition. Peri-anal diseases worsen the quality of life of both, pregnant and
postpartum women.
Main publications:
1. Z. Bumbuliene, J. Klimasenko, D. Sragyte, J. Zakareviciene, G. Drasutiene. Uterine
size and ovarian size in adolescents with functional hypothalamic amenorrhoea //
Archives of disease in childhood, 2015, Vol: 100 Iss: 10, p. 948-951, ISSN 0003-
9888, doi:10.1136/archdischild-2014-307504.
2. Š. Grincevičienė, L. Kubilienė, K. Ivanauskas, G.S. Drąsutienė, D. Ramašauskaitė, J.
Grincevičius, J. Bernatonienė, A. Savickas. Experiences of community pharmacists
advising pregnant women // International Journal of Clinical Pharmacy, 10 April
2015, p. 636-644. ISSN 2210-7703, DOI 10.1007/s11096-015-0111-6
MAIN R&D&I (RESEARCH, DEVELOPMENT AND INOVATION) PARTNERS
Zurich University (Switzerland)
Medical University of Silesia (Poland)
OTHER SCIENTIFIC ACTIVITIES
Prof. HP G. S. Drąsutienė –
editorial board member of the journal Lietuvos akušerija ir ginekologija (Lithuanian
Obstetrics & Gynecology);
member of Integrated Health Care Management Committee of Perinatology, Ministry
of Health, Republic of Lithuania;
Prof. N. Drazdienė –
editorial board member of the journal Lietuvos akušerija ir ginekologija (Lithuanian
Obstetrics & Gynecology);
editorial board member of the journal Naujagimis (Newborn child);
board member of Lithuanian Pediatric Society and Vilnius Pediatric Society.
vicepresident of Integrated Health Care Management Committee of Perinatology,
Ministry of Health, Republic of Lithuania;
vicepresident of Lithuanian Association of Neonatology;
head of Lithuanian section of German-Baltic Physician Society
Doc. J. Ališauskas
editorial board member of the journal Lietuvos akušerija ir ginekologija (Lithuanian
Obstetrics & Gynecology);
Doc. A. Arlauskienė
board member of Lithuanian Society of Obstetricians Gynecologists;
member of scientific committee of Lithuanian Society of Obstetricians Gynecologists;
editorial board member of the journal Lietuvos akušerija ir ginekologija (Lithuanian
Obstetrics & Gynecology.
member of European Cervical Cancer Association (ECCA);
member of International Society of Ultrasound in Obstetrics and Gynecology
(ISUOG)
Doc. D. Ramašauskaitė
board member of Vilnius region Society of Obstetricians Gynecologists.
Doc. J. Zakarevičienė
editorial board member of the journal Medicinos teorija ir praktika (Theory and
Practice in Medicine).
board member of Vilnius region Society of Obstetrics and Gynecology.
Doc. Ž. Bumbulienė
head of section of Lithuanian Society of Obstetricians Gynecologists;
board member of Vilnius Medical Society;
secretary general of EURAPAG (European Association of Paediatric and Adolescent
Gynaecology);
Doc. M. Šilkūnas
chairman of Vilnius region Society of Obstetrics and Gynecology;
board member of Lithuanian Society of Obstetricians Gynecologists;
V. Paliulytė –
board member of Vilnius region Society of Obstetricians Gynecologists.
DEPARTMENT OF ANATOMY, HISTOLOGY AND ANTHROPOLOGY
M. K. Čiurlionio 21/27, LT-03101 Vilnius
Phones: + 370 5 239 87 06, + 370 5 239 87 07,
Fax: + 370 5 239 87 05
E-mail: [email protected]
http://www.aha.mf.vu.lt
Head – Prof. dr. (HP) Janina Tutkuvienė
STAFF
Professors: dr. (HP) R. Jankauskas, dr. (HP) J. Tutkuvienė.
Associate professors: Dr. A. Barkus, Dr. R. Čepulienė, Dr. E.M. Jakimavičienė, Dr. Ž.
Miliauskienė, Dr. R. Šimkūnaitė-Rizgelienė, Dr. A. Suchomlinov, Dr. V. Tutkus (part-time),
Dr. V. Žalgevičienė.
Lecturers: J. Janavičius (part-time).
Assistants: A.Audickaitė, D. Bandzevičienė (part-time), V. Bartuškienė, R. Girčius (part-
time), R. Jacevičiūtė (part-time), K. Kuolienė (part-time), M. Minsevičius, R. Morkūnienė, K.
Popov (part-time).
Research fellows: S. Šilovė
Doctoral students: V. Bartuškienė, J. Drąsutis, K. Kuolienė, A. Vaitiekus
RESEARCH INTERESTS
Human Genome Diversity, Its Origin and Phenotypic Realization
Skeletal and dental health indicators in Lithuanian paleopopulations and potential ecological,
social, demographic factors of their variability
The peculiarities and factors of prenatal development, growth programming and postnatal
development in both humans and experimental animals (chicken embryos, rats)
The physical status of contemporary inhabitants, the internal and external factors of
phenotypic variation, the relationship between indices of physical and general health status,
the analysis of secular trend and prognosis of future tendencies.
RESEARCH PROJECTS CARRIED OUT IN 2015
Projects Supported by University Budget
Phenotype Variety of Inhabitants of Lithuania, Its Prenatal and Postnatal Factors,
Secular changes, Relations with General Health Status. Prof. J. Tutkuvienė, Prof. R.
Jankauskas. 2014 –2018.
Bioarcheological investigations. Collection of morphometric, paleopathological and
paleodemographical data of Lithuanian populations from Medieval and Modern times, also
new skeletal samples and their routine analysis was continued. Epidemiology of trauma from
Iron Age Lithuanian burials, and anthropological data from Vilnius Subačiaus str. sample
were summarized. Stable isotope analysis of selected Lithuanian paleopopulations are under
way. Data on mumified remains analysis published. Data on social differences of dental
health of medieval burials from Trakai published. Sexual dimorphism of clavicle in relation
to humerus size was investigated in 200 individuals obtained from the paleo- collections, and
the results were presented during the international conference.
Main publications:
1. Panzer S., Mc Coy M.R., Hitzl W., Piombino-Mascali D., Jankauskas R., Zink A.R.,
Augat P. (2015). Checklist and Scoring System for the Assessment of Soft Tissue
Preservation in CT Examinations of Human Mummies. PLOS ONE. 10(8): Article
Number: e0133364.
2. Piombino-Mascali D., Jankauskas R., Zink A.R., Todesco M.S., Aufderheide A.C.,
Panzer S. (2015). Paleoradiology of the Savoca Mummies, Sicily, Italy (18th-19th
Centuries AD). The Anatomical Record. 298(6): 988-1000.
3. Miliauskienė Ž, Jankauskas R. (2015). Social differences in oral health: Dental status
of individuals buried in and around Trakai Church in Lithuania (16th-17th c.c.).
Anthropologischer Anzeiger. 72(1): 89-106.
Experimental (growth programming) investigations The study of the influence of
maternal nutrition prior to pregnancy and during the pregnancy on two rat offspring
generations was continued. The experimental data of the adult to pre-senile age rat offspring
were obtained. The biometric body parameters and performed complete blood count and
biochemical blood tests were observed. Offspring in the elevated T-maze for the behavioral
indices of anxiety and stress were also studied. A sample of randomly selected individuals
was sacrificed and samples of various organs and tissues prepared for histopathological
analysis. The studies of prenatal ontogenesis in relation to ionized and fluoridate water and
the experiments on the influence of quantum dots on rats embryos were continued. The
regulative and regenerative potencies of transplanted chick limb buds were analysed. The
results were presented in the international conference „The 8th Baltic Morphology Scientific
Conference: Interdisciplinary Nature of Contemporary Morphology“, November 12-14th,
2015.
Investigations of the physical status of contemporary inhabitants. The analysis of data on
body size and general health status of Lithuanian newborns in relation to socio-economic
factors during the 1995–2013 was continued, results were presented in the national
conference and the publication was prepared. Growth curves of newborns’ head
circumference by gestational age and sex were calculated for newborns of 22-42 gestational
weeks, the results were presented in the international conference. Data on prevalence of birth
anomalies during the 1997-2013 were analyzed, the results were presented in the
international conference. Body size of newborns in relation to grandmothers pregnancy
(N=202) was investigated, the results were presented in the international conference.
The results on Lithuanian longitudinal growth study (1990-2008) – the relationship between
birth weight, adiposity rebound and overweight at the age of 17 years were published. The
analysis of data on physical status and nutritional habits of preschool children (N=66) was
continued and publication was prepared. Data on physical status of Vilnius children (N=716)
born in 1996 were further analyzed and publication was submitted. The analysis of data on
physical, health status and body image of 4-18 years old children (N=163) from Vilnius
municipal foster homes was continued and material for publication was prepared. Menarcheal
age and premenstrual syndrome of Vilnius city girls (N=1303) was investigated, the results
from 2015 were compared to former Lithuanian and studies from the other countries, the
results were presented during the international conference. The study of the physical status in
adolescents and young adults with refractive errors was continued (N=114). Studies of female
facial attractiveness in relation to morphological facial features (30 young males evaluated
standard photos of 100 young females) were continued; the accuracy in age and sex
estimation from facial images of preschool children (80 assessors evaluated standard photos
120 children) was studied, the results were presented during the international conference. The
study of breast changes in females during the pregnancy and after delivery was continued
(N=273); the results were presented in the international conference. The study on the
relationship between axis of the lower extremity, the alignment of joints, the lower limb
function and physical status of young adults was started: 89 healthy students of 19-25 years
old were investigated according to wide anthropometrical and functional program, the results
were presented in the international conference. The prevalence of patellar chondromalacia in
arthroscopically treated patients (N=214) was obtained, the results were presented during the
international conference.
Main publications:
1. Hermanussen M., et al. “Proceedings of the 22nd Aschauer Soiree on Growth and
Health Screening”, held at Altenhof, Germany, November 15th, 2014. Pediatric
Endocrinology Reviews 2015; 12(3):323-332.
2. Suchomlinov A, Tutkuvienė J. Variability in growth tracking is associated with body
mass index at 17 years of age. Acta Paediatrica 2015; 104:e401-406.
3. Suchomlinov A, Tutkuvienė J. Factors associated with chldren‘s height and body
mass index in Lithuania, 1990-2008. Journal of Biosocial Science 2015;
DOI:10.1017/S0021932015000243.
4. Suchomlinov A, Tutkuvienė J. The absence of physiological neonatal weight loss on
the 1st-5th day is associated with decreased later physical indices. Annals of Human Biology
2015; DOI:10.3109/03014460.2015.1119310.
National Research Projects
Research Council of Lithuania. The beginnings of Lithuanian statehood according to the
exploration of Dubingiai microregion (No. VP1-3.1-ŠMM-07-K-01-037). Prof. R.
Jankauskas. 2011-2015. Project completed. Monograph published: Kuncevičius A., Laužikas
R., Jankauskas R., Augustinavičius R., Šmigelskas R. (2015). Dubingių mikroregionas ir
Lietuvos valstybės ištakos. Vilniaus universitetas. 362 p.
Neolithisation of the eastern Baltics (No. VP1-3.1-ŠMM-07-K-01-037). prof. R.
Jankauskas. 2013-2015. Revision of current paleoantropological data, selection and
submission of samples for radiocarbon dating, stable isotope analysis, ancient DNA analysis.
Initial analysis of data from laboratory samples. Project completed; series of papers in
preparation.
International Research Projects
Funeral culture of elites in 15th-18th centuries on the territory of the Kindgom of
Poland and the Grand Duchy of Lithuania. Attempt of interdisciplinary analysis
(University of Torun, Poland). Prof. R.Jankauskas – foreign partner. 2012-2015. Project
completed. Monograph published: Grupa M., Kozlowski T., Jankauskas R., Grupa D.,
Krajewska M., Krakowska S., Majorek M., Mosiejczyk J., Nowak M., Nowak S.,
Przymorska-Sztuczka M., Wojciechowska A. (2015). Tajemnice krypty w kaplicy sw.Anny /
Secrets of the crypt in St.Ann chapel. Gniew. 189 p.
Molecular history and paleogenetic links between Polish and Lithuanian populations -
ancient DNA analysis since the Neolithic (Medical University of Lodz, Poland). Prof.
R.Jankauskas – principal foreign partner. 2013-2016. Selection of additional dental samples
for human and pathogen genome analysis from the Iron Age Lithuania; initial laboratory data
are analysed.
MAIN R&D&I (RESEARCH, DEVELOPMENT AND INOVATION) PARTNERS
Institute of Anthropology, University of Vienna (Austria)
Institute of Forensic Medicine, Heinrich-Heine University of Düsseldorf (Germany)
Max-Planck-Institute, Andechs, Germany
Medical University of Lodz (Poland)
University of Central Florida (Orlando, Florida, USA)
University of Torun (Poland)
State Forensic Medicine Service (Lithuania)
OTHER SCIENTIFIC ACTIVITIES
Prof. J. Tutkuvienė –
vice-dean for Research and PhD studies of the Faculty of Medicine;
member of the Council of the Faculty of Medicine;
chair of the Scientific Committee of the Faculty of Medicine;
chair of the Doctoral Committee of the Faculty of Medicine;
member of the European Anthropological Association;
member of the Council of the European Anthropological Association;
member of the Commission for Human Ecology of International Union of
Anthropological and Ethnological Sciences (IUAES);
member of the International Association of Human Biologists;
member of the Society for Studies of Human Biology;
member of the International Auxollogical Society;
member of the Lithuanian Morphological Society;
member of the Commission of Human Morphology of the Lithuanian Academy of
Sciences;
member of the Lithuanian Society of Obstetricians and Gynaecologists (Section of
Gynaecology of Children and Adolescents);
editorial board member of the Journal of Human Ecology;
editorial board member of the journal Acta Medica Lituanica;
editorial board member of the journal Visuomenes Sveikata (Public health);
editorial board member of the journal Anthropologischer Anzeiger;
editorial board member of the journal Вестник Московского университета. Серия 23.
Антропология.
Prof. R. Jankauskas –
Pro-Rector for Research, Vilnius University;
editorial board member of the journals Papers on Anthropology (Tartu University,
Estonia; http://www.tyk.ee/anthropology);
Anthropologischer Anzeiger (Germany;
http://www.schweizerbart.de/journals/anthranz/editorialboard);
Lietuvos archeologija; Archaeologia Baltica
(http://briai.ku.lt/en/publications/archaeologia-baltica/editorial-board/); Medicinos teorija
ir praktika (http://www.mtp.lt/lt/redaktoriu-kolegija-8/);
member of the Board of the European Anthropological Association
(http://eaa.elte.hu/administration_council.html);
member of the Scientific Council of the Lithuanian Institute of History
(http://www.istorija.lt/struktura/taryba/);
member of the Scintific Council of the Nature Research Center
(http://www.gamtostyrimai.lt/en/about_us/scientific_council)
member of Lithuanian Academy of Sciences (http://lma.lt/old/intranetas/).
Doc. A. Barkus –
member of the Lithuanian Morphological Society;
member of the European Anthropological Association;
member of the Lithuanian Society of Archaeology
Doc. R. Čepulienė –
member of the Lithuanian Morphological Society;
• member of the World‘s Poultry Science Association
Doc. E. M. Jakimavičienė –
member of the European Anthropological Association;
member of the International Auxological Society;
member of the Lithuanian Morphological Society.
Doc. Ž. Miliauskienė –
member of the Lithuanian Morphological Society;
member of Paleopathology Association;
member of the European Anthropological Association;
member of the Lithuanian Society of Archaeology.
Doc. A. Suchomlinov –
member of the European Anthropological Association;
member of the International Auxological Society;
member of the Lithuanian Morphological Society.
Doc. R. Šimkūnaitė-Rizgelienė –
member of the European Anthropological Association;
chair of the Lithuanian Morphological Society;
member of the Committee of Medical Studies Programme;
Chair of the Appeal Commission of the Faculty of Medicine.
Doc. V. Tutkus
member of European Society of Sports Traumatology, Knee Surgery and Arthroscopy
(ESSKA);
member of International Society of Arthroscopy, Knee Surgery and Orthopaedic Sports
Medicine (ISAKOS);
member of Lithuanian Association of Arthroscopic Surgeons;
member of Lithuanian Society of Orthopaedics and Traumatology;
member of Lithuanian Society of Plastic and Reconstructive Surgery;
member of the ethics committee of Lithuanian Society of Plastic and Reconstructive
Surgery;
member of Lithuanian Bioethical Committee.
Doc. V. Žalgevičienė –
board member of the Lithuanian Morphological Society;
member of Baltic Laboratory Animal Association (Balt-LASA).
J. Janavičius –
president of Lithuanian Hand Surgery and Rehabilitation Society ,,Manus
Lithuanica“;
member of Lithuanian foot surgery society;
member of International Federation of Societies for Surgery of the Hand;
member of European Foot and Ankle Society.
A. Audickaitė
member of the Lithuanian Dermatovenereology Society;
member of the European Academy of Dermatology and Venereology.
D. Bandzevičienė –
member of the Lithuanian Morphological Society.
V. Bartuškienė –
member of the European Anthropological Association;
member of the Lithuanian Morphological Society.
R. Girčius –
member of the Radiological Society of North America.
R. Jacevičiūtė –
member of the Lithuanian Morphological Society.
K. Kuolienė –
member of the European Anthropological Association;
member of Lithuanian Ophthalmologists Society;
member of the Association for Research in Vision and Ophthalmology.
R. Morkūnienė
member of Lithuanian Pediatric Society
K. Popov
member of Lithuanian Society of Orthopaedics and Traumatology.
A. Vaitiekus
member of Lithuanian Society of Orthopaedics and Traumatology;
member of Lithuanian foot surgery society;
member of European foot and ancle association (EFAS);
member of Lithuanian Association of Arthroscopic Surgeons
CLINIC OF ANAESTHESIOLOGY AND REANIMATOLOGY
Santariškių str. 2, LT-08661, Vilnius
Phone: 236 5235
E-mail: [email protected]
Head – Prof. Dr. Jūratė Šipylaitė
STAFF
Professors: Dr. J. Šipylaitė, Dr. S.Vosylius.
Docents: Dr. A. Andrijauskas, Dr. E. Kontrimavičiūtė, Dr. M. Šerpytis, Dr. D. Činčikas.
Lecturers: Dr. A. Klimašauskas, Dr. S. Švedienė, Dr. I. Norkienė.
Assistants: A. Vaitkus (part-time), R. Badaras (part-time), E. Gaižauskas (part-time).
Junior research fellows: Š. Judickas (part-time).
Doctoral students: R. Badaras, D. Ringaitienė, A. Vaitkus
RESEARCH INTERESTS
Etiopathogenesis, Diagnostics, Treatment of Diseases: Fundamental and Clinical
Research, Innovative Technologies
Influence of malnutrition on rate of complications and duration of hospital stay in patients
after cardiac surgery
The comparison of stress response in rapid opioid detoxication
The influence of perioperative optimization on the results of primary endoprosthesis of the
hip joint
Risk factors for organ dysfunction in patients with severe acute pancreatitis
Optimization of low back pain diagnosis and treatment
RESEARCH PROJECTS CARRIED OUT IN 2015
Project Supported by University Budget
Perioperative Patient Optimization and Management of Critical States. Prof. Dr. J.
Šipylaitė. 2014–2018
Retrospective observational case–control study was carried out in order to clarify the risk
factors for acute renal impairment (ARI) in patients with severe acute pancreatitis. Our study
revealed that hemodynamic instability and intraabdominal hypertension are the main
mechanisms of ARI. The results were presented in the 33rd Congress of the Scandinavian
Society of Anaesthesiology and Intensive Care (SSAI) in Reykjavik, Iceland, as oral
presentation „Acute kidney injury in acute pancreatitis”.
We performed a prospective study of 63 healthy volunteers to identify alternative maneuvers
that significantly increase cross-sectional area of internal jugular veins. We found that hold of
deep breath and 45-degree leg lift (the later limited for right side only) are alternative
maneuvers to improve visualization of internal jugular vein for conscious patients. The
results were presented in the 33rd Congress of the Scandinavian Society of Anaesthesiology
and Intensive Care as oral presentation „Is Trendelenburg position the only way to visualize
internal jugular veins better“.
Data of 10 patients undergoing carotid endarterectomy operations were analyzed and the
article Noninvasive cerebral oxymetry during carotid endarterectomy: application and
results was published in Acta medica Lituanica.
100 women were asked to fill in a questionnaire about pain management during labour. Data
was collected, statistical analysis completed and article Epidural anesthesia in obstetrics:
feelings of pregnant women, information sources and willingness to change pain relief
method during next childbirth was published in Acta medica Lituanica.
A retrospective data review of 271 patient data was conducted in order to identify the
prevalence and impact of hyperlactatemia on postoperative outcomes, morbidity and
mortality following cardiac surgery with cardiopulmonary bypass. Study groups were defined
according to post-operative lactate levels. Poster presentation “Post-operative lactate levels
predict rate of complications and length of stay following on-pump cardiac surgery” was
made at European Society of Intensive care annual meeting, Berlin and published in Intensive
Care Medicine Experimental 2015.
Perioperative use of Normal Saline is linked to hyperchloraemic or Strong Ion Difference
(SID) related acidosis. The study was aimed to establish effects of routine use of RL on post-
operative changes in SID and whether these changes result in metabolic acidosis. Poster
presentation “Use of ringer’s lactate solution does not eliminate the risk of strong ion
difference related metabolic acidosis following on pump cardiac surgery” was made at
European Society of Intensive Care annual meeting Berlin and published in Intensive Care
Medicine Experimental 2015.
A prospective clinical trial “The relationship between malnutrition, rate of complications and
duration of hospital stay in patients after cardiac surgery” was continued to evaluate the
impact of malnutrition in patients undergoing cardiac surgery. Study data was presented at
European Association of Cardiothoracic Anesthesiologists annual meeting in Gothenburg.
A study was carried out on the incidence of postoperative delirium development in
malnourished patients undergoing on pump bypass and an article „Impact of malnutrition on
postoperative delirium development after on pump coronary artery bypass grafting“ was
published in the Journal of Cardiothoracic Surgery.
We completed a prospective study „Postoperative glucose variability: association with
clinical outcome after cardiac surgery“. The study confirmed the association between an
increased postoperative glucose variability and rate of adverse clinical outcomes after cardiac
surgery and was presented at the Annual Congress of European Society of Clinical Nutrition
and Metabolism, Lisbon and at the 28th Annual Congress European Society of Intensive care
in Berlin.
The data collection and statistical analysis in clinical trial “The comparison of stress response
in rapid opioid detoxification procedure using different methods of opioid antagonist
naltrexone induction and sedation” was completed. Oral presentation about final results of
trial was presented in XXXV EAPCCT conference in Malta and has been short-listed for the
Informa prize for best scientific presentation. Doctoral theses are being prepared.
A prospective clinical trial protocol “Value of quantitative sensory testing and lumbar
sympathetic block for diagnosis and treatment of low back pain” was prepared and confirmed
by Regional Biomedical Research Ethics Committee. Trial was registered at the institution at
which it will be carried out.
Main publications:
1. D. Ringaitiene, D. Gineityte, V. Vicka, T. Zvirblis, J. Sipylaite, A. Irnius, J.
Ivaskevicius, T. Kacergius. Impacts of malnutrition on postoperative delirium
development after on pump coronary artery bypass grafting. Journal of Cardiothoracic
Surgery (2015) May 20; 10:74. DOI: 10.1186/s13019-015-0278-xp.s.
2. E. Kontrimavičiūtė, V. Kuzminskaitė, J. Šipylaitė. „Noninvasive cerebral oxymetry
during carotid endarterectomy: application and results“. Acta medica Lituanica, ISSN
1392-0138, Vol. 22, No 2 (2015), 55-60.
3. A. Basarinaite, A. Bucaite, E. Kontrimaviciute, J. Sipylaite, D. Ramanauskaite.
„Epidural anesthesia in obstetrics: feelings of pregnant women, information sources
and willingness to change pain relief method during next childbirth“. Acta medica
Lituanica, ISSN 1392-0138,Vol. 22, No 1, 15-23.
National Research Projects
The influence of perioperative optimization on the results of primary endoprosthesis of
the hip joint. Prof. Ch.H. Svensen, doc. A. Andrijauskas. 2013 - 2015.
We completed the prospective randomized clinical trial 'The influence of perioperative
optimization on the results of primary endoprosthesis of the hip joint' funded by the European
Social Fund under the Global Grant measure (VP1-3.1-ŠMM-07-K-03-019; the EU Structural
Funds). The patient enrollment and data collection were finished. Data analysis was started.
Preliminary results were made public in three poster presentations during
EUROANAESTHESIA 2015 congress (Berlin).
Main publications:
1. Andrijauskas A, Ivaskevicius J, Porvaneckas N, Stankevicius E, Svensen CH,
Uvarovas V, Svediene S, Kvederas G. A mini volume loading test for indication of
preoperative dehydration in surgical patients. Medicina (2015). DOI:
10.1016/j.medici.2015.02.001
2. Andrijauskas A, Markevicius V, Navikas D, Porvaneckas N, Andriukaitis D,
Stankevicius E, Uvarovas V, Sipylaite J, Kvederas G, Gelzinis G. In Vivo Testing of
the Semi-Closed Loop Infusion System: the Preliminary Observations.
ELEKTRONIKA IR ELEKTROTECHNIKA (Electronics and Electrical
Engineering); 2015; 21 (1). DOI: 10.5755/j01.eee.21.1.2458
MAIN R&D&I (RESEARCH, DEVELOPMENT AND INOVATION) PARTNERS
Research and Education, Department of Clinical Science and Education, Karolinska
Institutet/Södersjukhuset Section of Anaesthesiology and Intensive Care (Sweden)
OTHER SCIENTIFIC ACTIVITIES
Prof. J. Šipylaitė –
president of the Lithuanian Society of Anaesthesiology and Intensive Care,
member of the European Society of Anaesthesiology;
chairman of Committee of Medical Studies Programme;
member of the Board of Anaesthesiology of Medical Specialists of the European
Union;
editorial board member of the journal Medicinos teorija ir praktika (Theory and
Practice in Medicine).
Doc. M. Šerpytis –
treasurer of the Lithuanian Society of Anaesthesiology and Intensive Care.
Prof. S. Vosylius –
member of the Lithuanian Society of Anaesthesiology and Intensive Care;
member of the European Society of Intensive Care Medicine;
editorial board member of the journal Lietuvos chirurgija (Lithuanian Surgery).
Dr. A. Klimašauskas –
president of the Lithuanian Society for Parenteral and Enteral Nutrition;
member of the Lithuanian Society of Anaesthesiology and Intensive Care.
Doc. A. Andrijauskas, Doc. D. Činčikas, Doc. E. Kontrimavičiūtė, Dr. I. Norkienė,
Dr. S. Švedienė –
member of the Lithuanian Society of Anaesthesiology and Intensive Care.
CLINIC OF EAR, NOSE, THROAT AND EYES DISEASES
Santariskiu str. 2, LT-08661 Vilnius
Phone: +370 5 236 52 70, +370 2501867; fax: +370 5 236 52 70
E-mail: [email protected]
Head – Prof. dr. Eugenijus Lesinskas
STAFF
Professors: Dr. E. Lesinskas
Associate professors: Dr. M. Petrulionis, Dr. R. Ašoklis, Dr. A. Cimbalas,
Lecturers: Dr. D. Aukštikalnis, Dr. R. Pliaukšta, Dr. D. Rauba, Dr. J. Ivaška, Dr. S.
Galgauskas
Assistants: V. Beleškienė, A. Matulevičius, K. Malyško.
RESEARCH INTERESTS
Estimation of the influence of morphology and clinical peculiarities of otorhinolaryngological
and ophtalmological diseases to results of application of novel diagnostic methods and
treatment
RESEARCH PROJECTS CARRIED OUT IN 2015
Projects Supported by University Budget
An Influence of Morphology and Clinical Peculiarities of Otorhinolaryngological and
Ophtalmological Diseases to Results of Application of Novel Diagnostic Methods and
Treatment. Prof. E. Lesinskas. 2014-2018.
Clinical assessment and analysis of data were made for the scientific projects. New diagnostic
and treatment possibilities for Eustachian tube dysfunction were evaluated. Features of
sonotubometry for healthy personss and for persons with nasal obstruction and chronic otitis
were assesed. Efficacy of ET laser tuboplasty and prognostic factors were set.
Ocular posterior pole changes in glaucomatous eyes. Prevalence of retinal dystrophies and
degenerations in Lithuania. Evaluation of intraocular pressure, choroidal and retinal thickness
measurements using optical coherence tomography in non-diabetic haemodialysis patients.
Corneal endothelial cell and posterior pole changes in patients with central retinal vein or
branch occlusion. Choroidal thickness mesurements in diabetic patients with macular edema
treated with VEGF innhibitors. Correlation of macular degeneration autofluorescence
findings with functional impairment. The use of autofluorescence findings for differential
diagnosis of uveal melanomas. Evaluation of the anterior chamber changes after laser
iridotomies by optical coherence tomography. Evaluation of the retinal nerve fiber layer
thickness and its relation to visual evoked potentials in multiple sclerosis.
Main publications:
1. Beleškiene V, Lesinskas E, Januškienė V, Daunoravičienė K, Rauba D, Ivaška J,
Eustachian tube opening measurement by sonotubometry using perfect sequences for
healthy adults. Clinical and Experimental Otolaryngology. Accepted for publication
July 29, 2015
2. Galgauskas S, Laurinavičiūtė G, Norvydaitė D, Stech S, Ašoklis R Changes in
choroidal thickness and corneal parameters in diabetic eyes. Eur J Ophthalmol. 2015
Sep 14:0. doi: 10.5301/ejo.5000677
OTHER SCIENTIFIC ACTIVITIES
Prof. E. Lesinskas
senior otorhynolaryngologist of the Ministry of Health Care of the Republic of
Lithuania;
president of the Lithuanian Society of Otorhinolaryngologists;
member of the Council of the Faculty of Medicine;
editorial boord member of Journals “Medicinos teorija ir praktika”, Journal of
Hearing Science.
Dr. D. Rauba –
board member of Lithuanian Society of Otorhinolaryngologists.
Dr. R. Pliaukšta –
chairman of Vilnius Society of Otorhinolaryngologists.
Dr. R. Ašoklis –
board member of Lithuanian Society of Ophthalmologists.
board member of Vilnius County Ophthalmologists Association
member of European Board of Ophthalmology
national delegate in European Union of Medical Specialists
national delegate in International Council of Ophthalmology 2013 -2016
Dr. A. Cimbalas
board member of Lithuanian Society of Ophthalmologists
board member of Vilnius County Ophthalmologists Association
member of Lithuanian Glaucoma Society
international member of American Academy of Ophthalmology
Dr. S. Galgauskas
board member of Vilnius County Ophthalmologists Association
member of Lithuanian Society of Ophthalmologists
member of Lithuanian Glaucoma Society
member of European Association for Vision and Eye Research
member of Association for Research in Vision and Ophthalmology
DEPARTMENT OF PHYSIOLOGY, BIOCHEMISTRY, MICROBIOLOGY AND
LABORATORY MEDICINE
M. K. Čiurlionio str. 21/27, LT-03101 Vilnius
Tel.: 239 8720, 239 8719, 239 8718; fax 239 8745
E-mail: [email protected]
Head – Prof. Habil. Dr., Full Member of the Lithuanian Academy of Sciences Zita Aušrelė
Kučinskienė
STAFF
Professors: Habil. Dr. Z. A. Kučinskienė, Dr. (HP) A. J. Abaravičius, Dr. (HP) A.
Kaminskas.
Associate professors: Dr. L. Bagdonaitė, Dr. R. Budrionienė, Dr. V. Hendrixson, Dr. V.
Jablonskienė, Dr. T. Kačergius, Dr. S. Abaravičienė, Dr. R. Matuzevičienė, Dr. J. Valiūnienė,
Dr. D. Vitkus.
Lecturers: Dr. V. Banys (part-time), dr. D. Karčiauskaitė, Dr. A. Kirkliauskienė, Dr. S.
Kiverytė, E. Malyško, A. Mažeikienė , dr. D. Paškevičienė, R. Petraitis (part-time).
Assistants: M. Davidonis (part time), L. Gečienė, Ž.Chomanskis (part-time), V. Makarevič,
E.Ostanevičiūtė (part-time), M. Radzevičius (part time), I. Rudnickaitė (part time),
E.Totmianinienė (part-time), L.Vasiliauskaitė (part time), A. Virbalis (part time), V. Žėkas.
Senior research fellows: Dr. D. Karčiauskaitė.
Research fellows: Dr. S.Abaravičienė, Dr. L. Bagdonaitė, Dr. Ž. Daunonavičius (part time),
M. Bratčikov, Dr. T. Kačergius.
Junior research fellows: M. Janeliūnienė (part-time), E. Malyško, A. Mažeikienė,
E.Ostanevičiūtė (part-time), V. Žėkas.
Doctoral students: A. Mažeikienė.
RESEARCH INTERESTS
Research and investigation of ethiopathogenetic mechanisms of atherosclerosis
Research and investigation of new methods in laboratory diagnostics of diseases
Investigation of nutrition and evaluation of new high quality food products with increased
biological value to human health
Development of new antimicrobials for control of the medically important bacterial biofilms
Design of new molecular biology techniques for identification of the pathogenic and
commensal microorganisms, genotyping, antimicrobial resistance and epidemiology.
RESEARCH PROJECTS CARRIED OUT IN 2015
Projects Supported by University Budget
Investigation of Environmental and Metabolic Factors in the Pathogenesis of
Atherosclerosis. Prof. Z. A. Kučinskienė. 2014–2018
The aim – was to evaluate the etiopathogenetic relationship between different clinical
manifestation of atherosclerosis: coronary heart disease and metabolic syndrome. Different
diagnostic biomarkers in healthy individuals and patients with coronary heart disease and
metabolic syndrome were investigated, including routine and new parameters: lipids,
apoproteins, lipoproteins, adipose tissue and blood fatty acids’ composition and its relation
with nutrition, stress, inflammation, immunological, genetic markers, and status of oxidative-
antioxidant system. Nutrition of different patient groups and the impact of new high quality
food products with increased biological value to human health were evaluated.
Main publications:
1. Bironaite D, Daunoravicius D, Bogomolovas J, Cibiras S, Vitkus D, Zurauskas E,
Zasytyte I, Rucinskas K, Labeit S, Venalis A, Grabauskiene V. Molecular mechanisms
behind progressing chronic inflammatory dilated cardiomyopathy. BMC Cardiovasc
Disord 2015 Mar 26;15(1): 26.
2. Karčiauskaitė D, Kemežytė-Selmistraitienė G, Žėkas V. Ankstyvosios aterosklerozės
patogenezė ir laboratorinė diagnostika. Laboratorinė medicina 2015; 17(1): 25–29.
(Index Copernicus)
3. Asta Mazeikiene, Žydrūnas Daunoravičius, Zita Aušrelė Kučinskienė. Serumo
karotenoidų kiekio tyrimas ir sąsajos su gyvensenos bei demografiniais veiksniais
lietuvių populiacijoje. Laboratorinė medicina 2015; (3): 95–102. (Index Copernicus)
Human cytomics: research of diagnostic, predictive and treatment monitoring markers
and analysis methods for cellular diseases. Prof. Z. A. Kučinskienė, Assoc. Prof. R.
Matuzevičienė. 2014 – 2018.
The method of flow cytometry for the diagnostics and minimal residual disease detection of
haematological disorders was optimized. New methods for leukemic cell phenotyping were
introduced.
Fundamental, clinical and epidemiological studies on pathogenic and opportunistic
microorganisms involved in the pathogenesis of human diseases. Assoc. Prof. Dr. T.
Kačergius, Dr. S. Kiverytė. 2014–2018.
The aims were: 1) to assess the efficacy of peptide nucleic acids and phosphorothioate
antisense oligonucleotides for the inhibition of streptococci biofilms’ formation in order to
prevent oral, respiratory tract, skin and cardiovascular infections; 2) to evaluate the
effectiveness of new molecular biology techniques for the identification, genotyping,
determination of antimicrobial resistance markers and epidemiology of pathogenic and
opportunistic microorganisms. The results were as follows: 1) it was determined the
inhibitory effect of antisense oligonucleotides based on peptide nucleic acids and
phosphorothioate chemistry for the formation of oral streptococci biofilms; 2) it was
developed and optimized High Resolution Melting PCR (HRM-PCR) technology for
genotyping of ESBLs CTX-M group of Enterobacteriaceae.
Main publications:
1. Petraitienė S, Alasevičius T, Stacevičienė I, Vaičiūnienė D, Kačergius T, Usonis V. The
influence of Streptococcus pneumoniae nasopharyngeal colonization on the clinical
outcome of the respiratory tract infections in preschool children. BMC Infectious
Diseases. ISSN 1471-2334. 2015, 15: 403. (ISI Web of Science)
2. Ringaitienė D, Gineitytė D, Vicka V, Žvirblis T, Šipylaitė J, Irnius A, Ivaškevičius J,
Kačergius T. Impact of malnutrition on postoperative delirium development after on
pump coronary artery bypass grafting. Journal of Cardiothoracic Surgery. ISSN: 1749-
8090. 2015, 10: 74. (ISI Web of Science)
3. Kalesinskas P, Kačergius T, Ambrozaitis A, Jimbo R, Ericson D. Streptococcus mutans
biofilm inhibition using antisense oligonucleotide to glucosyltransferases B and C. Acta
medica Lituanica. ISSN: 1392–0138. 2015; 22(2): 85–92. (Index Copernicus, Index
Academicus, EBSCO)
National Research Projects:
Investigation of bioactive substances in food matrices and their influence on human
health. (Together with the Food Institute of Kaunas University of Technology). Principal
Investigator – prof. A. Kaminskas. 2012–2015
In the last years consumers demand for functional foods that prevent disease and improve
health has noticeably increased. The positive effect of such foods on human health depends
on the biologically active ingredients. The polyunsaturated omega-fatty acids (PUFA),
biologically active dietary fiber (BADF) among them prebiotic dietary fibre (PDF),
biologically active milk protein (BAMP), soy protein isolate, Ca are the most promising
functional ingredients. Some of them are sensitive to environmental factors (light, heat,
oxygen et cetera). So, during the technological process the stability and biological activity of
these ingredients particularly depends on the composition and the features of the food
matrixes, physico-chemical methods applied and storage conditions.
The aim of this project is to select the matrixes for nonalcoholic drinks and drinks from
buttermilk and milk whey, investigate and optimize the methods for inserting PFA, BADF,
PDF, BAMP, soy protein isolate, Ca into selected drink matrixes, investigate the influence of
technological factors (stirring, homogenization, heat-treatment, refrigeration et cetera) on the
physico-chemical, microbiological, sensory characteristics and qualitative and quantitative
stability of biological active ingredients in the food matrixes in fresh state and during storage.
The prototypes of technologies for functional beverages with bioactive ingredients will be
developed. The effect of the functional beverages, prepared at the experimental conditions,
on the human health will be examined by performing complex clinical studies at the Medical
Faculty of VU. Obtained new scientific information will be important for the food science
and could be applied in the practice of food enterprises in organizing and production of new
safe and competitive in market functional food products with bioactive ingredients.
Main publications:
1. Liutkevičius Algirdas, Speičienė Vilma, Alenčikienė Gitana, Mieželienė Aldona,
Kaminskas Arvydas, Abaravičius Jonas Algis, Vitkus Dalius, Jablonskienė Valerija. Oat
β-glucan in milk products: impact on human health. Journal of international scientific
publications: Agriculture and food. Burgas : Info Invest. ISSN 1314-8591. 2015; 3: 74-
81. (ISI Web of Science)
2. Liutkevicius A, Speiciene V, Kaminskas A, Jablonskiene V, Alencikiene G, Miezeliene
A, Bagdonaitė L, Vitkus D, Garmienė D. Development of a functional whey beverage,
containing calcium, vitamin D, and prebiotic dietary fiber, and its influence on human
health. CyTA - Journal of Food, DOI: 10.1080/19476337.2015.1108366. (ISI Web of
Science)
Research Council of Lithuania. Impact of chronic stress on atherosclerosis process:
search and investigation of new biomarkers” (No. MIP-050/2015). Prof. Z. Kučinskienė.
2015–2018 m.
Idea, purposes and objectives of the research. Atherosclerosis is a complex process that
develops gradually over many years or even decades until clinical presentation.
Atherosclerotic cardiovascular diseases remain the major cause of deaths worldwide. Since
the death rates from cardiovascular diseases are generally higher in Lithuania than in Western
European countries and traditional risk factors not always explains this higher morbidity,
other atherosclerosis risk factors are considered. Psychological factors have significant
impact on pathogenesis, progression and complications of atherosclerosis, but mechanisms
underlying these associations are not completely clear. In our work we are planning a
complex investigation of effects of chronic psychological stress that are associated with
atherosclerosis pathogenesis – dysfunction of hypothalamus-pituitary-adrenal (HPA) axis,
activation of platelets, oxidative stress and inflammation. The evaluation of chronic stress
will be evaluated not only using specific questionnaires, but also by accumulated amount of
cortisol in hair and compared with the baseline secretion of cortisol determined by its
concentration in saliva in the morning. Malondialdehyde, total antioxidant activity and
concentration of antioxidants - carotenoids in blood will be used as biomarkers of oxidative
stress levels. Inflammation will be evaluated by a high sensitivity C-reactive protein,
interleukin-6 and the new biomarker cyclophilin A, which is proposed to be mechanistical
link between oxidative stress and smooth muscle cells proliferation. Platelet activity will be
evaluated by their degranulation, aggregation and adhesion (using CD63, PAC21, CD107a
markers) and leukocyte and platelet aggregates (CD45, CD14 markers)
Main publication:
Viktorija Andrejevaitė, Virginijus Šapoka, Dovilė Karčiauskaitė, Zita Aušrelė Kučinskienė,
Valdas Banys, Vytautas Kasiulevičius, Grytė Bieliauskaitė, Gediminas Navickas, Reda
Šulčytė. Rūkančių vyrų nerimo sutrikimų ir biocheminių uždegimo žymenų ryšys.
Laboratorinė medicina. 2015;17,1: 8–14. (Index Copernicus)
Research Council of Lithuania. Peptide nucleic acids applications for inhibition of
streptococci biofilms (PAISBI) (Eureka: VP1-3.1-ŠMM-06-V-01-003; Agency for
Science, Innovation and Technology). Dr. M. Bratčikov. 2013–2015.
The aim of the PAISBI project was to develop antisense oligonucleotide technology on the
basis of peptide nucleic acids for inhibition of streptococci biofilm formation that can be
applied for designing of new antibacterial biopharmaceuticals. The results revealed that the
antisense oligonucleotides based on peptide nucleic acid chemistry inhibited the biofilm
formation in oral streptococci. However, it was found out that the effect occurred in a non-
specific manner.
Research Council of Lithuania. Biotechnology and biopharmacy: fundamental and
applied research (VP-3.1-ŠMM-08-K-01-005; 1.1.1.4). Lect. Dr. S. Kiverytė, Dr. M.
Bratčikov. 2012–2015.
The aim of this project was to adjust a multiple-run high resolution melting assay for the
molecular identification of microorganisms, genotyping and markers of antibacterial
resistance. High Resolution Melting PCR technology (HRM-PCR) was developed and
optimised for genotyping of ESBLs CTX-M group of Enterobacteriaceae. Publication is
under preparation.
Partners of the project:
Genetic diversity of the population of Lithuania and changes of its genetic structure
related with evolution and common diseases” Acronym – “LITGEN”.
Project number: VP1-3.1-ŠMM-07-K-01-013. Prof. V. Kučinskas. 2011–2015.
The main strategic goals of this project are: to estimate the features of genetic diversity and
structure of the Lithuanian population according to DNA markers associated with the most
widely used in the investigation of the genetic diversity, structure and ancestry of world
populations by applying high-throughput genomic, bioinformatical and biostatistical
technologies; to create preconditions for human genome wide scale complex investigations in
Lithuania, its phenotypic expression and integration into contemporary international research
programmes.
Main publications:
1. Modeling linkage disequilibrium increases accuracy of polygenic risk scores / Ripke
S, Neale BM, Corvin A.Schizophrenia Working Group of the Psychiatric Genomics
Consortium, [Kucinskiene ZA]. Am J Hum Genet 2015, Oct 1; 97(4): 576-92. doi:
10.1016/j.ajg.2015.09.001. (ISI Web of Science)
2. LD Score regression distinguishes confounding from polygenicity in genome-wide
association studies/Bulik-Sullivan BK, Loh PR, Finucane HK, Ripke S, Yang J;
Schizophrenia Working Group of the Psychiatric Genomics Consortium, Patterson N,
Daly MJ, Price AL, Neale BM. [Kučinskienė ZA.]. Nat Genet. 2015 Mar; 47(3): 291–
5. doi: 10.1038/ng.3211. Epub 2015 Feb 2. (ISI Web of Science)
3. Neringa Burokienė, Dovilė Karčiauskaitė, Vytautas Kasiulevičius, Vaidutis
Kučinskas, Zita Aušrelė Kučinskienė. Širdies ir kraujagyslių ligų sąsajos su
aterosklerozės rizikos veiksniais ir biocheminiais žymenimis Lietuvos populiacijoje.
Laboratorinė medicina 2015; 17(2): 47 – 52. (Index Copernicus)
Partners of the EU funded project “Renovation of laboratory diagnostics infrastructure
of PI Kaunas Clinics”, project code VP3-2.1-SAM-10-V-01-110. 2013–2015.
The aim of the project – improvement of the infrastructure of the providers of laboratory
diagnostics services in Lithuania as a tool for the preparation for accreditation acording to the
standard ISO EN 15189: 2012 „Medical laboratories. Requirements for quality and
competence“. During the project package of 10 scientific and managerial recommendations
for medical laboratories have been prepared.
Diagnostic and prognostic value of biomarkers for patients hospitalised due to acute
heart failure: prospective observational multicenter cohort study
Project is carried out by Vilnius University together with a partner Lithuanian university of
Health Sciences, in conjunction with a research protocol of international GREAT consortium
(Global Research on Acute Conditions Team). MIP 049/2015. 2015–2018. Dr. J. Čelutkienė.
Investigator – Assoc. Prof. Dr. L.Bagdonaitė.
The aim is to evaluate the diagnostic value and regional differences of novel biomarkers, their
predictive value for risk of death and rehospitalisation in acute heart failure (AHF) patients.
The first aggregated larger scale observational and biomarkers database of AHF patients in
Lithuania will provide demographic data and trends of morbidity and mortality, as well as
analysis of diagnostic and prognostic value of novel biomarkers in our region. The
determinants of regional differences in the levels of natriureuretic peptides and markers of
renal impairment will be investigated. Generated knowledge will contribute to the
understanding of basic pathophysiologic mechanisms of AHF. It is expected that optimal use
of novel biomarkers in the setting of emergency and critical care would reduce unnecessary
hospitalizations, cost and duration of hospitalizations without decrease in the quality of
diagnostics and treatment.
Publication:
N Giedraitiene, G. Kaubrys, R. Kizlaitiene, L. Bagdonaite, L. Griskevicius, V. Valceckiene
M. Stoskus. Therapeutic Plasma Exchange in Multiple Sclerosis Patients with Abolished
Interferon-beta Bioavailability. Medical science monitor: international medical journal of
experimental and clinical research 05/2015; 21:1512-9. DOI:10.12659/MSM.894119
International Research Projects:
NOPHO – ALL 2008 Treatment Protocol for Children (1.0 - 17.9 years of age) and
young adults (18-45 years of age) with Acute Lymphoblastic Leukemia NOPHO (Nordic
Pediatric Hemato-Oncology) group http://www.nopho.org/welcome/frame.htm Vilnius
University Children’s Hospital http://www.vaikuligonine.lt/centras.php?cen_id=2
Organizer of the Project – Nordic Society of Paediatric Haematology and Oncology
(NOPHO) (www.nopho.org).Countries involved in the Project: Denmark, Sweden, Finland,
Iceland, Norway, Lithuania, Estonia, Latvia.
Flow Cytometry Coordinator of the Project in Lithuania: Assoc. Prof. R. Matuzevičienė.
The outcome of paediatric acute myeloid leukaemia is still unsatisfactory with an overall
survival around 70% and a relapse rate of 30-40% after primary treatment. The primary aim
of the NOPHO-DBH AML 2012 study is to improve EFS and OS in children with AML. The
protocol is a collaborative research study including the BSPHO, DCOG, Hong Kong and
NOPHO paediatric AML groups. The patient group includes children and adolescents up to
19 years of age with de novo AML excluding patients with MDS-AML, myeloid leukaemia
of Down syndrome and acute promyelocytic leukaemia. To improve outcome, an intensified
induction regimen will be given and a response guided risk-group stratification using flow
cytometric minimal residual disease measurements to evaluate therapy response will be used.
Patients with a poor response to the two induction courses will be assigned to the high-risk
group and receive consolidation therapy including stem cell transplantation whereas those
with a good response will be given three chemotherapy courses as consolidation therapy. An
exception are patients with good response and inv(16), who will not be given HAM and thus
receive two consolidation courses only. The only other cytogenetic feature that will affect
risk stratification is the presence of an FLT3-ITD mutation which, when not associated with
concomitant nucleophosmin (NPM1) mutation, will stratify patients to the high-risk group.
Effective induction therapy is crucial for outcome in AML and MRD levels following
induction are highly predictive of outcome. AML 2012 includes two randomised studies that
both address the efficacy of induction therapy. The first study is based on the induction
course from the Japanese AML99 trial and compares the efficacy of mitoxantrone and
DaunoXome in the first treatment course. The primary outcome measure is the MRD level on
day 22 from start of the course. The second study compares ADxE (low-dose cytarabine,
DaunoXome and etoposide) with FLADx (fludarabine, high-dose cytarabine and
DaunoXome) as the second induction course. The primary endpoint is the MRD level at day
22 from start of the course. Secondary outcome measures in both studies include EFS, OS,
remission rate and toxicity. AML 2012 is scheduled to run between five and six years and
expected to recruit at least 300 patients. The study incorporates strict guidelines for
cytogenetic characterisation of the disease and a standardised approach to flow cytometric
MRD determination with central review of data files. Toxicity will be carefully monitored
and the study will be conducted according to GCP guidelines.
International joint project with Malmö University, Sweden, and AL-Qasemi Research
Center, Israel: Effect of Rhus plant extract and its active fractions on biofilm formation
in bacterial systems. Assoc. Prof. Dr. T. Kačergius, Prof. Dr. D. Ericson (Sweden), Prof.
Dr. A. Rayan (Israel). 2015–2017.
The aim of this research was to investigate whether the crude extract of Rhus plant inhibits
Streptococcus mutans biofilm formation and acid production in vitro conditions. It was
revealed that the crude extract of Rhus plant significantly suppressed the biofilm formation
and acid production as compared to the untreated bacteria. Importantly, this inhibitory effect
occurred in the dose-dependent manner.
MAIN R&D&I (RESEARCH, DEVELOPMENT AND INOVATION) PARTNERS
NOPHO (Nordic Pediatric Hemato-Oncology) group,
http://www.nopho.org/welcome/frame.htm
Malmö University, Malmö (Sweden)
Clinical Institute of Chemistry, Zagreb, (Croatia)
Food Institute of Kaunas University of Technology (Lithuania)
Department of Human and Medical Genetics of Faculty of Medicine of Vilnius University
OTHER SCIENTIFIC ACTIVITIES
Prof. Z. A. Kučinskienė –
member of the Senate of Vilnius University.
chairman of the Senate Scientific Committee of Vilnius University.
full Member of the Lithuanian Academy of Sciences.
member of the Board of the Faculty of Medicine of Vilnius University.
past-President of the Baltic Atherosclerosis Society.
member of the American Association of Clinical Chemistry (AACC).
member of the European Atherosclerosis Society (EAS).
member of the Board of the Lithuanian Society of Laboratory Medicine, www.llmd.lt;
member of the Lithuanian Society of Human Genetics.
editor-in-chief of the journal Laboratorinė medicina (Laboratory Medicine),
www.llmd.lt;
editorial board member of the journals: Acta Medica Lituanica, Medicina, Medicinos
teorija ir praktika, Sveikatos mokslai, Seminars in Cardiology.
member of the International Scientific committee of the EUROMEDLAB Paris
(IFCC-EFLM 21st European Congress of Clinical Chemistry and Laboratory
Medicine), Paris, June 21-25, 2015.
Prof. A. J. Abaravičius –
member of the National Committee of New Food Products (approved by the order
Ministry of Health (2003-01-22 No. V-33).
member of the Lithuanian Society of Laboratory Medicine, www.llmd.lt
member of Lithuanian Physiological Society.
Prof. A. Kaminskas –
secretary and member of the Board of the Faculty of Medicine.
member of the committee of the medical study program.
member of the Lithuanian Society of Laboratory Medicine, www.llmd.lt
executive editor of the journal Medicinos teorija ir praktika (Theory and Practice in
Medicine), www.mtp.lt.
Assoc. Prof. L. Bagdonaitė –
member of the Lithuanian Society of Laboratory Medicine, www.llmd.lt
member of the Lithuanian Society of Allergology and Clinical Immunology.
member of the European Atherosclerosis Society (EAS).
Assoc. Prof. V. Jablonskienė –
editorial board member of the journal Laboratorinė medicina (Laboratory Medicine).
executive editor of the journal Laboratorinė medicina (Laboratory Medicine),
www.llmd.lt;
member of the Lithuanian Society of Laboratory Medicine, www.llmd.lt
Assoc. Prof. V. Hendrixson –
Vice Dean of the faculty of Medicine for International Relations and Projects;
academic Erasmus Coordinator.
member of the Lithuanian Society of Laboratory Medicine, www.llmd.lt.
open Medical Institute Lithuanian Association of Neuroscience
Federation of European Neuroscience Societies (FENS)
Honorary Professor of the Karaganda State Medical University
Assoc. Prof. T. Kačergius –
member of the Lithuanian Society of Medical Microbiologists.
Assoc. Prof. R. Matuzevičienė –
editorial board member of the journals Laboratorinė medicina (Laboratory Medicine),
www.llmd.lt, Gydytojų žinios (Doctors’ News).
member and board member of the Lithuanian Society of Laboratory Medicine,
www.llmd.lt.
member of the Lithuanian Society of Haematology.
member of the Lithuanian Society of Allergology and Clinical Immunology.
member of the Lithuaninan Medical Association.
member of the European Society for Clinical Cell Analysis – ESCCA.
Assoc. Prof. D. Vitkus –
president of the Lithuanian Society of Laboratory Medicine.
National Representative at the International Federation of Clinical Chemistry and
Laboratory Medicine (IFCC).
National Representative at the European Federation of Clinical Chemistry and
Laboratory Medicine (EFLM).
National Representative at the Registration Commission of the European Society of
Clinical Chemistry and Laboratory Medicine (EFLM).
member at large of the Board of Baltic Association of Laboratory Medicine.
member of the American Association for Clinical Chemistry.
corresponding Member of the Committee of Nomenclature for Properties and Units of
Scientific Division of the International Federation of Clinical Chemistry and
Laboratory Medicine (IFCC).
corresponding Member of the Committee of Reference Systems of Enzymes of
Scientific Division of the IFCC.
corresponding Member of the Committee of Traceability in Laboratory Medicine of
Scientific Division of the IFCC.
member of the Board of Editors of the scientific journal “Laboratory Medicine” ISSN
1392-6470.
Lect. D. Karčiauskaitė –
member of Lithuanian Laboratory Medicine Society.
member of European Atherosclerosis Society.
Lect. A. Kirkliauskienė –
member of the Lithuanian Society of Laboratory Medicine.
Member of the Lithuanian Society of Infectious Diseases.
Lect. S. Kiverytė –
Member of the European Society of Clinical Virology.
Member of the Lithuanian Society of Laboratory medicine.
Lect. V. Banys –
President of the Board of Vilnius Subsidiary of Lithuanian Society of Laboratory
Medicine.
Board member (treasurer) of Lithuanian Society of Laboratory Medicine.
Member of the American Association of Clinical Chemistry (AACC).
Member of International Society on Thrombosis and Haemostasis. (ISTH), Clinical
and Laboratory Standards Institute (CLSI).
Lect. A. Mažeikienė –
Member of European Atherosclerosis Society (EAS).
Member of the Lithuanian Society of Laboratory medicine.
GASTROENTEROLOGY, NEPHROUROLOGY AND SURGERY CLINIC
Santariškių str. 2, LT-08661 Vilnius
Tel. 236 5250, fax 236 5101
E-mail: [email protected]
Head – Prof. habil. dr. Kęstutis Strupas
STAFF
Professors: Habil. Dr. K. Strupas, Dr.(HP) V. Beiša, Dr. E. Poškus, Dr. T. Poškus, Dr. G.
Simutis, Dr. A. Šileikis, Dr. (HP) G. Brimas, Habil. Dr. F. Jankevičius, Dr. M. Miglinas,
Habil. Dr. J. Valantinas
Associate profesors: dr. V.Jotautas, dr. V. Sokolovas, Dr. K. Trainavičius, Dr. K. Saniukas,
Dr. G. Verkauskas, Dr. H. Ramonas, Dr. A. Želvys, Dr. A. Černiauskienė, Dr. L. Andreikas,
Dr. G. Denapienė, Dr. E. Gavelienė, Dr. A. Stašinskas, Dr. A. Gradauskas.
Lecturers: Dr. S. Mikalauskas, G. Pošiūnas, Dr. L. Rimševičius, Dr. I. Stundienė, Dr. L.
Mašalaitė, R. Vaicekauskas, Dr. I. Savlan.
Assistants: P. Gradauskas, B. Buckus, D. Kubilius, E. Brazdžiūtė.
Research fellows: Dr. V. Liakina, M. Petrulionis
Doctoral students: A. Karpavičius, A. Rybakovas, A. Beiša, D. Danys, J. Tumas, A.
Buivydienė, A. Mickevičius, B. Buckus, A. Laučytė-Cibulskienė, A. Strumila, G.
Bernotavičius, N. Staikūnienė, A. Gaižauskas, L. Rimševičius, M. Barisienė, E. Brazdžiūtė,
A. Bakavičius.
RESEARCH INTERESTS
Minimally invasive surgery of abdominal organs, development and improvement of new
procedures and devices for the performance of minimally invasive procedures, especially of
abdominal malignancies
Research of liver and pancreas transplantation techniques (listing and preparing of patients
for liver, pancreas, kidney transplantation)
Research of liver and pancreas transplantation techniques
Study of dietary treatment of enteropathies
Minimal hepatic encephalopathy
Diagnostic/prognostic markers for prediction of HCC
Novel treatment for the GI bleeding
Contemporary diagnostic analysis of ascite liquid
Epidemiology and novel treatment of viral hepatitis
RESEARCH PROJECTS CARRIED OUT IN 2015
Projects Supported by University Budget
Investigation efficiency of traumatic – restorative, minimally invasive surgeries and
transplantation methods in visceral surgery. Prof. K. Strupas, prof. G. Brimas. 2014 –
2018.
Possibilities and results of minimally invasive surgery in patients with recurrent inguinal
hernias, spleen, liver, adrenal gland, thyroid and parathyroid glands, pancreas and colorectal
pathology were collected and evaluated. Results of the research in 2015 were presented in 6th
workshop of European Society of Endocrine Surgery in Varna, Bulgaria.
The successful organ-tissues transplantations-program in Vilnius University Santariškių
Hospital is the best fact to take Vilnius University Hospital as the leader Transplantation
Center in the Baltic States (K.Strupas, V.Sokolovas, J.Jurgaitis, M.Paskonis).
The prospective multicenter study "Value of inflammation markers for early assessment of
the severity of acute pancreatitis (AP)" was finished and doctoral dissertation was defended
in 2015. The aim of this study is to identify the significant laboratory markers, which can be
used to predict the course, complications and outcomes of AP. The predictive value of
adiponectin, leptin, resistin, visfatin, IL-6, trypsinogen 2 were investigated. The relationship
between serum concentration of these markers, clinical course and CT findings of acute
pancreatitis patients was detected. Four hospitals participated in the study. All of them are
working under one protocol, which is approved by the Lithuanian Bioethics Committee. 109
acute pancreatitis patients were included in the study.
In collaboration with the Department of General Surgery, University of Heidelberg
(Germany) the experimental studies were continued (K.Strupas, R.Račkauskas).
The prospective clinical study BRAFV600E mutation and other molecular markers for
diagnosis of thyroid malignancies was continued in 2015. After the investigation of BRAF
v600e mutation prevalence, sensitivity and specificity in the thyroid cancer, we are planning
to create a new guideline in diagnosis, treatment and monitoring of thyroid nodules and to
reduce the amount of diagnostic thyroid surgery. 300 patients are involved in this study.
Poster presentation entitled “The potential utility of BRAF V600E status follow-up in FNA
of thyroid nodules” was presented in 6th
workshop of European Society of Endocrine Surgery
in Varna, Bulgaria.
The prospective multicentric study„The risk factors and clinical value of hypocalcaemia after
total thyroidectomy“ (Prof.V.Beiša, V.Eismontas, E.Zdanytė) in corporation with Klaipėda
University Hospital was launched in 2015 in order to evaluate possible factors in
postoperative hypocalcaemia, including preoperative mesurements of vitamin D, PTH, Ca,
FT4, FT3, paying special attention to surgical techniques, possible injuries to arterial
branches supplying parathyroid glands and postoperative predictors of hypocalcaemia. At the
moment this study is in progress, the planned number of patients is 400.
The study „The value of intraoperative neurostimulation in optimizing safety of
thyroidectomy” (Prof. K.Strupas, A.Rybakovas) is going to evaluate intraoperative palpation
method of intraoperative neurostimulation comparing it with intraoperative sonoscopy and
with posoperative laryngoscopy. The possibility of mathematical voice analysis is going to be
evaluated as well in order to develop simple vocal cord paralysis prediction model. The
decision of Bioethics committee is to be anounced in December 2015.
Main publication:
Buckus B, Brimas G, Stašinskas A, Smalenskaitė A, Tautkus S, Beganskienė A, Kareiva A.
Analytical characterization of adipose tissue structure and composition: a novel approach
towards diagnosis of metabolic disturbances in the human body. Chemistry. Lithuanian
Academy of Sciences Publishers, ISSN 0235-7216. T. 26, Nr. 2. 2015. p. 98-106.
Pathogenetic relationships of chronic liver disease with disorders of other abdominal
organs, improvement of therapeutic and surgical treatment. Prof. J. Valantinas. 2014 -
2018
Variceal recurrence following endoscopic band ligation (EBL) is common. Esophageal
collateral veins (ECV) are observed by endoscopic ultrasound (EUS) in patients with portal
hypertension. The aim of the present study was to assess the role of EUS in predicting the
recurrence of esophageal varices following EBL. Forty patients who had undergone EBL for
eradication of varices were examined over a 12-month period to detect variceal recurrence.
EUS was performed before ligation to detect and describe the type, grade, and the number of
ECV. EUS findings obtained prior to EBL were compared in the variceal recurrence and non-
recurrence groups.
Of the 40 patients, 19 (47.5%) had variceal recurrence within 12 months of EBL. Univariate
logistic regression analysis showed that severe peri-ECV (p < 0.001), multiple peri-ECV (p <
0.001), and the presence of perforating veins (p < 0.014) were statistically significantly
related to the variceal recurrence after EBL. Multivariate logistic regression model found that
only severe peri-ECV (odds ratio [OR] = 24.39; 95% confidence interval [CI]: 2.34–253.78)
and multiple peri-ECV (OR = 24.39; 95% CI: 2.34–253.78) remained as independent
prognostic factors for variceal recurrence. The sensitivity and specificity of multivariate
logistic regression model in predicting variceal recurrence was 89.2% and 90.5%,
respectively (prognostic value (AUC) = 0.946).
Recurrence rate of esophageal varices after EBL is high (47.5%). EUS can clearly depict
ECV and has a value in predicting variceal recurrence after EBL; severe peri-ECV and
multiple peri-ECV were significant and independent prognostic factors associated with
variceal recurrence risk.
Main publication:
Masalaite L, Valantinas J, Stanaitis J. Endoscopic ultrasound findings predict the recurrence
of esophageal varices after endoscopic band ligation: a prospective cohort study. Scand J
Gastroenterol. 2015; 50(11):1322-30.
The value of spectroscopy and and molecular markers in diagnosis and prognosis of
urological cancer. Prof. F. Jankevičius. 2014 - 2018.
A new method discriminating cancerous kidney tissue from healthy parenchyma measuring
vibrational spectra (IR absorption or SERS) from intracellular fluid has been developed. The
method is based on spectral analysis of tumor and healthy tissue in order to find characteristic
spectral markers. The most significant spectral differences – spectral markers - were found in
in the region between 400 and 180 cm -1
, where spectral bands related to various vibrations of
fatty acids, glycoluipids and carbohydrates are located. This investigation demonstrated that
spectral markers in the IR and SERS spectra are different and the methods can complement
each other. Both of them have potential to be used directly at the time of surgery.
For better characterization of the role of ABC transporters in prostate cancer (PCa)
development, the profile of ABC transporter gene expression was analyzed by real-time PCR
in a set of prostate cancer (PCa) cases (N = 78) and noncancerous prostate tissues (NPT)
(N = 15). Expression of eight ABC transporter genes (ABCA8, ABCB1, ABCC6, ABCC9,
ABCC10, ABCD2, ABCG2, and ABCG4) was significantly down-regulated in PCa as
compared to NPT, and only two genes (ABCC4 and ABCG1) were up-regulated. Down-
regulation of ABC transporter genes was more prevalent in the TMPRSS2-ERG-negative
cases. Moreover, the TMPRSS2-ERG-negative PCa cases showed significantly lower
expression of ABCB1 in comparison to NPT (p = 0.003) and the fusion-positive tumors
(p = 0.002). Promoter methylation of ABCB1 predominantly occurred in PCa and was rarely
detected in NPT (p < 0.001). These results suggest frequent down-regulation of the ABC
transporter genes in PCa, especially in the TMPRSS2-ERG-negative tumors.
Interfocal DNA methylation heterogeneity has been investigated in ten pairs of foci from
multifocal PCa and 15 benign prostatic hyperplasia (BPH) samples obtained from
prostatectomy specimens. Methylation-specific PCR (MSP) and pyrosequencing were used to
evaluate methylation status and intensity of nine tumor suppressor genes (TSGs). Promoter
sequences of the RASSF1 and ESR1 genes were methylated in all paired PCa foci, and
frequent (≥75 %) DNA methylation was detected in RARB, GSTP1, and ABCB1 genes. MSP
revealed different methylation status of at least one gene in separate foci in 8 out of 10
multifocal tumors. The mean methylation level of ESR1, GSTP1, RASSF1, and RARB
differed between the paired foci of all PCa cases. The intensity of DNA methylation in these
TSGs was significantly higher in PCa cases than in BPH (p < 0.001).Most interestingly, that
despite divergent methylation profile of paired PCa foci revealed on hierarchical cluster
analysis, the foci of separate cases with biochemical recurrence showed similar methylation
profile and the highest mean levels of DNA methylation. Differences in DNA methylation
status observed in paired tumor foci, confirms the heterogeneity of PCa tissue, while common
epigenetic profile of recurrent tumors may provide the basis for development of novel
prognostic markers.
Main publications:
1. Demidenko R, Razanauskas D, Daniunaite K, Lazutka JR, Jankevicius F, Jarmalaite
S. Frequent down-regulation of ABC transporter genes in prostate cancer. BMC
Cancer. 2015 Oct 12; 15:683.
2. Serenaite I, Daniunaite K, Jankevicius F, Laurinavicius A, Petroska D, Lazutka JR,
Jarmalaite S. Heterogeneity of DNA methylation in multifocal prostate cancer.
Virchows Arch. 2015 Jan; 466(1):53-9.
3. Velička M, Urboniene V, Čeponkus J, Pucetaite M, Jankevicius F, Sablinskas V.
Detection of cancerous biological tissue areas by means of infrared absorption and
SERS spectroscopy of intracellular fluid. Biosensing and Nanomedicine VIII, edited
by Hooman Mohseni, Massoud H. Agahi, Manijeh Razeghi. Proc. of SPIE Vol. 9550
95500A-6. 2015 SPIE.
National Research Projects
Research council of Lithuania. Colorectal cancer: study of mortality, disability and
quality of life in Lithuania supported by (grant LIG01/2011) was continued in 2014;
prospective study of the quality of life of patients after resections for colorectal cancer was
studied; the data was submitted to the American Society of Colon and Rectal Surgeons
meeting in USA in 2015.
The project “New biomarcers for individualized chemotherapy of colon cancer:
proteomics, RNA nomics, clinics” (No SEN-15069) started in 2015. Neoplastic diseases are
a major cause aggravating the quality of life of aging society. Colorectal cancer (CRC) is the
third most common cancer in men and the second in women worldwide, affecting mainly
people over 50 years old. Adjuvant combinational chemotherapy by 5 fluorouracil and
oxaliplatin (FOLFOX) is the established second line treatment of the CRC. The potential
efficiency of FOLFOX has to be evaluated before applying the treatment. However, although
FOLFOX has been used for CRC treatment for more than decade, no successful predictive
biomarkers have been introduced into clinic. The lack of such biomarkers can be explained
by the technical limitations of biomarker discovery methods that only recently have been
overcome by applying state of art high‐throughput quantitative proteomics and microRNA
sequencing. The combination of these latest techniques enables the establishment of the set of
predictive protein and microRNA biomarkers. Introduced into clinic, such set of biomarkers
would provide successful personalized treatment of CRC. In this project we will use
chemotherapy sensitive and resistant CRC cell lines that will be established or have been
established already. We will perform highthroughput quantitative proteomic and
microRNomic analysis of the cell lines. Potential predictive biomarkers will be identified
from the bioinformatic analysis of proteomic and microRNomic data and validated in various
models of cell culture. Next, the selected set of potential protein and microRNA biomarkers
will be validated in human CRC clinical samples. The project will result in the discovery of
potential predictive biomarkers for the successful personalized CRC adjuvant chemotherapy.
The research project „Identification of early diagnostic and prognostic biomarkers of
pancreatic intraductal adenocarcinoma using protein mass spectrometry analysis” was
continued in 2015. It focuses on tissue and serum biomarkers detection, suitable for early
diagnostics of pancreatic intraductal adenocarcinoma. During the year 2015, around 30
additional samples of different pancreas tissue specimens and 5 blood samples have been
collected and fresh-frozen stored in the tissue bank. 20 of them started to investigate by
Protein mass spectrometry.
International Science Programmers and Projects
Projects Supported by COST (European Concerted Research Action designated as COST
Action BM1204) were continued in 2015. An integrated European platform for pancreas
cancer research: from basic science to clinical and public health interventions for a rare
disease. The main objective of the Action is to capitalise on emerging scientific and
technological developments in the field of Pancreatic Ductal Adenocarcinoma (PDAC). On
27 April 2015 working group meeting was in the Tissue Bank of the National Center for
Tumor Diseases in Heidelberg (Germany) and on 06-09 November 2015 working groups
meeting and the Workshop/Conference “Burning issues in Pancreatology” - the Combined
EFIS & EPC meeting, and the pancreas Annual Conference, organized by UEG, EFIS,
EAPM and EU Pancreas was in Cluj-Napoca (Romania).
The disease burden of hepatitis C virus (HCV) infection and develop strategies that can
manage the burden. The Center for Disease Analysis (CDA), Amanda Sibley, Prof. J.
Valantinas.
Recent unpublished estimates from an ongoing national seroprevalence survey suggest an
anti-HCV prevalence of 1.96% among adults in Lithuania. While prevalence may be lower
than reported averages for the Eastern Europe region, HCV accounts for a substantial
proportion of hepatocellular cancer (HCC) and liver-related deaths in Lithuania. Recent
developments in antiviral regimens achieve higher sustained viral response rates (SVR) and
greater convenience than the current standard of care. To understand the impact of new
therapies on the burden of HCV in Lithuania, a modeling approach was used.
Disease progression was modeled using age-and gender-defined cohorts to track HCV
incidence, prevalence, morbidity and mortality. Baseline assumptions were derived from
published literature and unpublished data. Under the base case, it was assumed that 450 (300-
600) patients with moderate fibrosis (≥F2) were treated annually during 2014-2030 with
moderate efficacy (G1 SVR = 40%, G2 SVR = 80%, G3 SVR = 65%). The relative impact of
a scenario to increase efficacy and change treatment restrictions was considered in 2030.
Under this scenario, efficacy was increased in 2016 (≥F3 G1 SVR = 95%) and 2017 (≥F2 G1
SVR = 95%, ≥F2 G2&3 SVR = 90%). Beginning in 2019, higher efficacy treatment was
considered available to ≥F1 patients.
Under the base case, projections suggest total viremic infections will increase 5% by 2030
(from 32 970 in 2014 to 35 440 in 2030). Additionally, prevalent HCC cases and annual
liver-related deaths will increase 110%-120% from 40 and 50, respectively, in 2014 to 90 and
110, respectively in 2030.
Under a scenario to increase treatment efficacy and expand fibrosis restrictions, there will be
32 890 total viremic cases in 2030, a 7% reduction from the base case. By 2030, prevalent
HCC (80 in 2030) and annual liver related mortality (105 in 2030), will each be reduced <5%
from the base case in 2030.
The base case results demonstrate an increasing burden of HCV-attributable HCC cases and
liver related deaths in Lithuania. The results from a scenario to increase efficacy and treat
patients with mild fibrosis (≥F1), without increasing the number of patients treated, will have
little impact on total viremic cases or advanced outcomes such as HCC or liver-related
mortality.
Main publications:
1. Valantinas J, Liakina V, Speiciene D. Strategies to manage hepatitis C virus infection
disease burden - volume 3. J Viral Hepat. 2015; Dec 22 Suppl. 4:42-65.
2. Liakina V, Speiciene D, Valantinas J. The present and future disease burden of
hepatitis C virus infections with today's treatment paradigm - volume 3. J Viral Hepat.
2015; Dec 22 Suppl 4:21-41.
3. Liakina V, Speiciene D, Valantinas J. Historical epidemiology of hepatitis C virus
(HCV) in select countries - volume 3. J Viral Hepat. 2015; Dec 22 Suppl 4:4-20.
Family Studies in Primary Biliary Cirrhosis. 2008-2015
Mount Sinai Hospital, Dr. Katherine Siminovitch, Prof. J. Valantinas.
Our data identify CCL20 as a candidate risk gene for PBC. Chemokine ligand 20 (CCL20)
and its chemokine receptor CCR6 contribute to the formation and function of mucosal
lymphoid tissues and are notably, in the context of the immune-mediated lymphocytic
cholangitis characteristic of PBC, involved in the localization of Th17 cells and CD8 effector
T cells to cholangiocytes and the periductal area in portal tracts16. This study also reinforces
the importance of IL-12 and JAK-STAT signaling in this disease.
The identification of disease-associated regulatory variants at multiple risk loci emphasizes
the potential importance of gene regulation in the pathogenesis of PBC (and presumably
other complex disorders). This possibility is corroborated by the finding of numerous risk loci
wherein the index and/or closely related SNPs that appear to represent regulatory, mQTL
and/or eQTLs variants related to the nearby gene. Via the FGWAS analysis, this study also
suggests particular importance of CD20þ B cells and Th1 cells in the pathogenesis of PBC.
However, both the cell types and the specific gene variants most relevant to PBC require
further investigation and in particular exploration of the tissue-specific functional effects of
the disease-associated variants.
Main publication:
Liakina V, Gregersen PK; Italian PBC Genetics Study Group; UK-PBC Consortium,
Gershwin ME, Anderson CA, Lazaridis KN, Invernizzi P, Seldin MF, Sandford RN, Amos
CI, Siminovitch KA. International genome-wide meta-analysis identifies new primary biliary
cirrhosis risk loci and targetable pathogenic pathways. Nat Commun. 2015 Sep 22; 6:8019.
MAIN R&D&I (RESEARCH, DEVELOPMENT AND INOVATION) PARTNERS
University Clinical Charite, Medical Faculty of Humboldt University, Berlin (Germany)
University of Heidelberg (Germany)
Ludwig Maximilian University of Munchen (Germany)
Minimally Invasive Surgery Society of Germany (Germany)
University of Minnesota (USA)
University of Warsaw (Poland)
Lithuanian University of Health Science (Lithuania)
University of Latvia (Latvia)
Christian Albrechts University (Germany)
Toronto Western Hospitals (Toronto, Canada)
The Johns Hopkins University, School or Medicine and School of Public Health, Baltimore
(USA)
R. Adams Cowley Schock Trauma Center at the University of Maryland, Baltimore (USA)
Urology Clinic of Heinrich-Heine Duesseldorf University (Germany)
Urology Clinic of Eppendorf Hamburg University (Germany)
M.D. Andersen Cancer Center of Texas University, Huston (USA)
Heidelberg University, Heilderberg (Germany)
OTHER SCIENTIFIC ACTIVITIES
Prof. K. Strupas –
past President of Lithuanian Surgical Oncology society
board member of the European Academy of Surgical Scienses (EAcSS);
member of International Hepato-Pancreato-Biliary Association
member of the Scientific Committee of Vilnius University;
board member of the Association of Lithuanian Surgeons;
member of European Association for Endoscopic Surgery (EAES)
editorial board member of the international journal Viszeralmedizin;
(http://content.karger.com/ProdukteDB/produkte.asp?Aktion=JournalHome&Produkt
Nr=223970)
editorial board member of the journal Medicinos teorija ir praktika (Theory and
Practice in Medicine)http://www.mtp.lt
editorial board member of the journal Lietuvos chirurgija (Lithuanian Surgery)
http://www.chirurgija.lt
editorial board member of the journal Medicina (Lithuania,
ISI).http://medicina.kmu.lt
Prof. V. Beiša –
chairman of Vilnius Association of Surgeons
member of the European Society of Endocrine Surgeons (ESES);
member of the International Society of Surgery (ISS).
Prof. G. Simutis –
immediate past Chairman of the Lithuanian Minimally Invasive Surgery Society
member of Vilnius Association of Surgeons
member of Lithuanian Surgical Oncology society
member of European Association for Endoscopic Surgery (EAES)
Prof. E. Poškus -
chairman of the Lithuanian Minimally Invasive Surgery Society
member of Lithuanian Surgical Oncology society
member of the Lithuanian Society of Coloproctologists
member of the European Society of Coloproctology;
member of the International Society of University Colon and Rectal Surgeons
member of European Association for Endoscopic Surgery (EAES)
Prof. A. Šileikis –
secretary of Vilnius Association of Surgeons
member of the International HepatoPancreato Biliary Association (IHPB);
member of the American Society of Clinical Oncology (ASCO)
member of Lithuanian Surgical Oncology society
member of the Lithuanian Minimally Invasive Surgery Society
Prof. T. Poškus -
Vice-president of the Lithuanian Society of Coloproctologists.
member of Lithuanian Surgical Oncology society
member of Vilnius Association of Surgeons
Doc. V. Sokolovas -
President Lithuanian Association of Transplantology
member of the Lithuanian Minimally Invasive Surgery Society
member of Vilnius Association of Surgeons
member of Lithuanian Surgical Oncology society
member of the Lithuanian Enteral and Parenteral Nutrition Society
member of the Lithuanian Society of Gastroenterology
Doc. V. Jotautas-
member of the Lithuanian Minimally Invasive Surgery Society
member of Vilnius Association of Surgeons
member of the Lithuanian Society of Coloproctologists
member of European Association for Endoscopic Surgery (EAES)
Dr. S. Mikalauskas-
board member of the Lithuanian Minimally Invasive Surgery Society
member of Vilnius Association of Surgeons
member of the Lithuanian Society of Coloproctologists
member of European Association for Endoscopic Surgery (EAES)
member of Lithuanian Surgical Oncology society
Prof. J. Valantinas –
editor of the journal „Internistas“ supplement „Gastroenterology“
editorial board member of the journal “World Journal of Gastroenterology”
editor board member of the journal „Medicinos teorija ir praktika“
member of the International “Pancreas-2000“ scientists group
member of the European Association for the Study of the Liver (EASL).
member of the World Organization of Gastroenterology (OMGE).
President of the Lithuanian Society of Gastroenterology
Doc. E. Gavelienė –
member of the Lithuanian Society of Gastroenterology
member of the European Association of Enteral and Parenteral Nutrition.
Doc. G. Denapienė –
member of the Lithuanian Society of Gastroenterology
Dr. V. Liakina -
member of the European Association for the Study of the Liver (EASL).
member of the Lithuanian Society of Gastroenterology
member of the Lithuanian Society of Immunology
Dr. J. Stundienė -
member of the Lithuanian Society of Gastroenterology
Lect., dr. L. Mašalaitė -
member of the Lithuanian Society of Gastroenterology
Dr. I. Savlan -
member of the Lithuanian Society of Gastroenterology
Lect. R. Vaicekauskas –
member of the Lithuanian Society of Gastroenterology
Prof. G. Brimas -
deputy editor-in-Chief of the journal “Lietuvos chirurgija”.
editorial board member of the journal "Videosurgery and miniinvasive techniques".
President of the Association of Lithuanian Surgeons.
President of the Bariatric Surgery Society.
Doc. A. Stašinskas -
editorial board member of the journal “Lietuvos chirurgija“.
board member of the Association of Lithuanian Surgeons.
Doc. K. Saniukas –
President of the Baltic Spinal Cord Injury Scientific Society;
President of Lithuanian Scientific Society of Paediatric Orthopaedics and
Traumatology.
Doc. K. Trainavičius -
member of the Baltic Association of Pediatric Surgeons (BAOPS);
member of the Council of Lithuanian Society of Pediatric Surgery;
editorial board member of the journal Pediatrija (Paediatrics), www.idejugrupe.lt.
Prof. F.Jankevičius -
chairman of the Lithuanian Early Prostate Cancer Detection Programme.
member of th European Association of Urology (EAU).
corresponding Member of Deutschen Gesellschaft fur Urologie.
member of Lithuanian Urological Association.
Doc. H. Ramonas-
member of the Lithuanian Urology (LUD) Society;
member of the European Association of Urology (EAU);
member of the Lithuanian Society for Sexual Medicine (LSSM).
Doc. L. Andreika -
member of the Lithuanian Urology (LUD) Society;
member of the Lithuanian Medical Society.
Doc. A. Želvys
member of the Lithuanian Urology (LUD) Society;
member of the European Association of Urology (EAU);
member European Society for Organ Transplantation (ESOT);
member of the Lithuanian Nephrology Dialysis Transplantation Association
(LNDTA);
member of the Lithuanian Society for Sexual Medicine (LSSM).
Doc. A. Černiauskienė -
member of the Lithuanian Urology (LUD) Society;
member of the Lithuanian Society for Sexual Medicine (LSSM);
member of the Minimal Invazive Surgery Society;
member of Lithuanian Surgical Oncology society
Prof. M. Miglinas -
member of the European Dialysis Transplantation Association – European Renal
Association(EDTA-ERA);
member of the European Society of Hypertension (ESH);
member of the International Society of Nephrology (ISN);
member of the International Society of Hypertension (ISH);
Vise-President of the Lithuanian Nephrology Dialysis Transplantation Association
(LNDTA);
chairman of Lithuanian Kidney Foundation.
President of the Lithuanian Hypertension Society.
Cross of the Knight of the Order of the Lithuanian Grand Duke Gediminas.
Lect. L. Rimševičius -
member of the European Dialysis Transplantation Association – European Renal
Association (EDTA-ERA);
member of the International Society of Nephrology (ISN);
member of Lithuanian Nephrology, Dialysis and Transplantation Association
(LNDTA).
CLINIC OF INFECTIOUS, CHEST DISEASES, DERMATOVENEREOLOGY AND
ALLERGOLOGY
1 Birutės, LT-08117 Vilnius
Tel: +370 5 272 4657; fax: +370 5 275 8885
E-mail: [email protected]; [email protected]
Head – Prof. Habil. Dr. Arvydas Ambrozaitis
Centre of Infectious Diseases
1 Birutės, LT-08117 Vilnius
Tel: +370 5 272 4657; fax: +370 5 275 8885
E-mail: [email protected]; [email protected] ;
Head – Prof. Habil. Dr.Arvydas Ambrozaitis
Centre of Pulmonology and Allergology
2 Santariškių, LT-08661 Vilnius
Tel. +370 5 2501871
E-mail: [email protected]; [email protected]
Head – Prof. Dr. (HP) Edvardas Danila
Centre of General Thoracic Surgery
2 Santariškių, LT–08661 Vilnius
Tel./fax +370 5 2 611 636
E-mail: [email protected]; [email protected]
Head – Habil. Dr. Ričardas Janilionis
Centre of Dermatovenereology
2 J. Kairiūkščio, LT-08411 Vilnius
Tel. +370 5 272 0385, fax +370 5 272 0256
E-mail: [email protected], [email protected]
Head – Prof. Dr. M. Bylaitė-Bučinskienė
STAFF
Professors: Habil. Dr. A. Ambrozaitis, Dr. (HP) E.Danila, Habil.Dr. R. Dubakienė, Dr. M.
Bylaitė, Dr. K. Žagminas (part-time).
Associate professors: Habil.Dr. R.Janilionis, Dr. L. Jančorienė, Dr. R. Matulionytė, Dr. A.
Blažienė, Dr.R. Zablockis, Dr. V. Gruslys, Dr. J. Grigaitienė , Dr. R. Gancevičienė (part-
time).
Lecturers: Dr. D. Radzišauskienė (part-time), Dr. R.Gancevičienė (part-time), Dr. V.
Šileikienė (part-time), A. Marcinkutė (part-time), B. Zablockienė (part-time), I.Balčiūnienė
(part-time).
Assistant professors: T.Karmazienė (part-time), Ž.Jagelavičius (part-time), R.Aleksonienė
(part-time), R.Kibarskytė (part-time), I.Kiselienė (part-time).
Research fellows: Dr. V.Kvedarienė (part-time), Dr.L. Malinauskienė (part-time), A.
Stiklerytė.
Doctoral students: Ž. Jagelavičius, R .Jurčiukonytė, R. Aleksonienė, B. Zablockienė, I.
Balčiūnienė, E. Jurevičienė.
RESEARCH INTERESTS
Pathogenesis, diagnostics, treatment and prevention of infectious diseases: scientific
assessment of the current methods used in the diagnostics, treatment and prevention of
infectious diseases; search of a new diagnostics, treatment and prevention methods; study of
the mechanisms of infectious diseases pathogenesis; study of a safety and efficacy of a new
vaccines and drugs for the treatment and prevention of infectious diseases.
Etiology, pathogenesis, diagnostics and treatment of psoriasis, atopic dermatitis, acne and
hidradenitis suppurativa: fundamental and clinical research, innovative technologies.
Epidemiology, pathogenesis, diagnostics, treatment and prevention of epithelial skin cancers
and melanoma. Strategy and tactics of the surgical management of patients with different skin
pathology.
Evaluation of the efficacy of the diagnostic and therapeutic methods in obstructive,
interstitial, neoplastic and allergic disorders.
Strategy and tactics of the surgical management of patients with different thoracic pathology.
RESEARCH PROJECTS CARRIED OUT IN 2015
Projects Supported by University Budget
Pathogenesis, Diagnostics, Treatment and Prevention of Infectious Diseases. Prof. A.
Ambrozaitis, Assoc.prof. L. Jančorienė, Assoc.prof. R.Matulionytė, Prof. K. Žagminas,
D.Radzišauskienė, B.Zablockienė, A.Marcinkutė, A.Stiklerytė. 2014 – 2018.
Safety and efficacy of the triple antiviral therapy with telaprevir in treatment-naïve and
treatment experienced genotype 1 chronic hepatitis C patients with advanced fibrosis or
compensated liver cirrhosis. Assoc.prof. L. Jančorienė. Prof. A. Ambrozaitis
The aim of this study - to assess the safety and virologic response of telaprevir-based triple
therapy in genotype 1 CHC treatment-naïve and treatment–failure patients with bridging
fibrosis or liver cirrhosis. Significantly improved SVR (70.6%) with triple therapy was
achieved in treatment-naïve patients as compared with historical SVR results (44%) in dual
therapy. In treatment-failure group statistically significant benefit in achievment of SVR was
shown in previous relapsers (p=0,001) and partial responders (p=0,004) as compare with
previous non-responders. Most common adverse effects (anemia, rash, pruritus,
thrombocytopenia, neutropenia) gradually resolved after the treatment completion.
Triple antiviral therapy with boceprevir in genotype 1 treatment experienced hepatitis C
patients with bridging fibrosis or cirrhosis: safety and virologic response. Assoc. Prof.
L.Jančorienė, prof.A.Ambrozaitis.
The aim of this study - to investigate the safety and virologic response of boceprevir-based
triple antiviral therapy in treatment experienced genotype 1 CHC patients, with bridging
fibrosis or liver cirrhosis. SVR with boceprevir –based triple therapy was achieved in 47.1%
of genotype 1 CHC patients with bridging fibrosis or cirrhosis who previously had a failure to
dual treatment. Statistically significant benefit in achievement of SVR was shown in previous
relapsers (p=0,001) and partial responders (p=0,033) as compare with previous non-
responders. Most common side effects (anemia, thrombocytopenia, neutropenia, skin
reactions and mood disorders) gradually resolved after the treatment completion.
Tick-borne ecephalitis (TBE) in Vilnius region in 2005-2014: epidemiologic and clinical
aspects. D. Radzišauskienė, prof. K.Žagminas, assoc. prof. L. Jančorienė, prof.
A.Ambrozaitis.
The aim of this retrospective study is to assess the epidemiologic and clinical aspects of TBE
in Vilnius region during 2005 - 2014, including the descriptive analysis of TBE epidemiology
and determination of the main clinical features and sequelae of TBE in Vilnius region. In
2015 data from all the source documents were collected and entered into the specially
designed Data Collection Form and finally entered into the Epi database program. The final
data analysis will be conducted in 2016 and paper will be submitted for publication.
Prevalence of viral hepatitis A, B and C serological markers in the first time non-remunerated
blood donor’s population in Lithuania. Prof. A. Ambrozaitis, prof. K. Žagminas, assoc. prof.
L. Jančorienė, A. Stikleryte.
The objective of this cross-sectional study is to estimate the prevalence viral hepatitis
serologic and virologic markers, such as anti-HAV, HBsAg, HBV-DNR, anti-HBc, anti-HBs,
anti-HCV, HCV-RNA among the first-time non-remunerated blood donors in Lithuania.
Total of 200 first-time non-remunerated blood donors were tested in 2015 for VH serologic
markers. Total of 27 (13,5%) were positive for anti-HAV, 1 (0,5%) – for HBsAg, 1 (0,5%) –
for HBV-NAT, 5 (2,5%)- for anti-HBc, 110 (55%) – for anti-HBs, 5 (2,5%) – for anti-HCV,
4 (2%) – for HCV-NAT. All 200 sera samples tested for anti-HEV were negative. The study
is in progress.
Evaluation of preventive value of suppression in nitric oxide production for the development
of influenza-induced pneumonia. B. Zablockienė, prof. A.Ambrozaitis.
The aim of the study is to evaluate how neuraminidase inhibitors and iNOS antisense
suppress the pulmonary inflammation from the overproduction of free radicals during the
influenza infection in the mouse model. The nitrotyrosine and influenza nucleoprotein levels
in mice lungs were assessed by Western Blot analysis. The levels of iNOS RNR, IFN - γ,
TNF - α were determined using reverse transcriptase - polymerase chain reactions. The study
is in the process.
Evaluation of epidemiology and efficacy of the diagnostic and treatment methods in
lung and allergic diseases and disorders. Prof. E. Danila, prof. R. Dubakienė, Assoc. prof.
habil. dr. R. Janilionis, Assoc.prof. A. Blažienė, Assoc.prof. R. Zablockis, Assoc. prof. V.
Gruslys, dr. V. Kvedarienė, dr. L. Malinauskienė, dr. V. Šileikienė, R. Aleksonienė, Ž.
Jagelavičius. 2014 – 2018.
Diagnosis and Treatment of Interstitial Lung Diseases
The aim of the study is to evaluate the significance of bronchoalveolar lavage fluid
examination in sarcoid patients and patients with rare interstitial disorders (eosinophilic
pneumonija, hypersensitivity pneumonitis). Clinical symptoms, cell differentials and
distribution of lymphocyte subgroups in BALF, chest X-ray, spirometric indices, blood gases
are evaluated. The study is in the process.
Assessment of Pulmonary Function of Patients with Lung Diseases
Comparison of different methods for evaluation of bronchial obstruction. Evaluation of lung
ventilation reserve with different methods of lung ventilation reserve evaluation. Evaluation
of metabolic changes of patients with COPD. Changes of exercise tolerance of COPD
patients after treatment with corticosteroids and respiratory muscle function reduction in
patients with COPD are evaluated. The study is in the process.
D –dimer levels in pleural fluid
A significance of pleural fluid D-dimer concentration is evaluated in patients with pleural
effusion. The patients with cancer, parapneumonic effusion, tuberculosis, congestive heart
failure, pulmmonary embolism, uremia, and nephrotic sindrome are included into the study.
Pleural D-dimer levels are measured and compared with D-dimer concentrations in plasma.
Pleural fluid LDH, protein, pH, glucose levels are assessed as well. The study is in the
process.
Evaluation of hypersensitivity reactions to cytostatic drugs in patients with lung cancer
The aim of the study is to evaluate type of adverse reactions to different type of cytostatic
drugs in patients with lung cancer. Correlations between adverse reactions and patients’ age,
lung cancer stage and histological type are investigated. The study is in the process.
Differences between self-reported drug hypersensitivity reactions in Lithuanian adults and
children
The aim of study is to assess the prevalence of self-reported DHRs in adults and in children
and to analyse the risk factors in both groups. Cross-sectional survey of a population was
made. Total of 35 questions about drug allergy symptoms and also about food and pollen
allergy, family history were assessed. Preliminary data were presented at the EAACI ENDA
meeting in 2015. Final data are in assessment, preliminary analysis and publication in the
future.
Allergen immunotherapy: patients selection, efficacy of different methods and treatment
results
The aim of the study was to evaluate the clinical efficacy and adverse reactions in adults with
allergic rhinoconjuctivitis with or without asthma. Data were collected using our made
questionnaire from 47 patients. Total of 30 patients received SLIT, 17 – SCIT. There was no
statistical significant difference between SCIT and SLIT groups in terms of nose itching,
sneezing, rhinorrhea, nasal congestion, palate‘s and eyes‘ itching and asthma symptoms.
Eye’s tearing significantly improved in SLIT group after half a year. We conclude that
treatment with ASIT is effective and safe.
Textile dye allergy and allergic contact dermatitis
A total of 214 consecutive dermatitis patients from Lithuania were tested with the mix,
consisting of Disperse Blue 35, Disperse Yellow 3, Disperse Orange 1, Disperse Orange 3,
Disperse Red 1 and 17, all at 0.5%, and Disperse Blue 106 and 124, both at 0.1%, and with
the ingredients at these concentrations if the patients were positive to the mix. Of the total
number, 6 patients (2.8%) were positive to the mix and none were positive for separate dyes.
Investigating textiles randomly obtained all over the world we noticed similar pattern of dyes
on TLC plates among different extracts. We found that disperse dyes used for patch testing
are rarely found in the textiles, therefore we plan to investigate which disperse dyes are used.
The study is in the progress.
Patch tests in allergy diagnosis: Identifying opportunities and obstacles for good clinical
practice under current EU legislation
Actions taken in 2015 are:
a review of literature for gaining evidence to define the best patch test practice;
an analysis of present practices of patch testing used in EU countries;
a survey of expectations and concerns of European allergologists regarding this method
and it’s legal frameworks;
an analysis of legal regulations of patch test materials and procedures on the EU level, as
well as local regulations in EU Member State;
Identification of opportunities and obstacles for a better clinical practice under current EU
legislation;
Issuing a position paper with evidence-based guidelines for performing patch tests within
the current scientific and legislative context;
Main publications:
1. Pimkina E, Zablockis R, Nikolayevskyy V, Danila E, Davidavičienė E. The Xpert®
MTB/RIF assay in routine diagnosis of pulmonary tuberculosis: A multicentre study
in Lithuania. Respir Med 2015; 109: 1484-1489.
2. Malinauskienė L, Blažienė A, Chomičienė A, Isaksson M. Formaldehyde may be
found in cosmetic products even when unlabelled. Open Med 2015; 10: 323-328.
3. Bousquet J, Schunemann HJ, Fonseca J, Kvedariene V, Mercier J. MACVIA-ARIA
Sentinel NetworK for allergic rhinitis (MASK-rhinitis): the new generation
guideline implementation. Allergy 2015; 70: 1372-1392.
Strategy and Tactics of the Surgical Management of Patients with Different Thoracic
Pathology. Habil.dr. R. Janilionis
New surgical methods using ultrasound intraoperatively and VATS were elaborated for the
surgical management of the patients with pleuropulmonary suppurations. Tracheobronchial
resection and reconstruction for malignant and benign stenoses. Treatment of the patients
with chest trauma and sequelae. Surgical management of the patients with lung carcinoma
and surgical pathology of the mediastinum. Conservative (bougienage, dilation, stenting) and
surgical management of patients with tumorous and benign esophageal stenosis. Surgical
management of COPD patients. The value of videomediastinoscopy and videoassisted
thoracoscopic surgery in diagnostics and management of the patients was assessed.
Publication:
Ž.Jagelavičius, G.Vaitėnas, V.Jovaišas, R.Janilionis Riboto piopneumotorakso gydymas
vakuumine žaizdų gydymo sistema //Lietuvos chirurgija ISSN 1648-9942, 2015,
Vol.14(1),P.46-51.
Diagnostic and treatment peculiarities of basal cell carcinoma. Prof. Dr. M. Bylaitė-
Bučinskienė , R. Jurčiukonytė.
The aim of the study is to assess the demographic data, etiology, pathogenesis, diagnostics
and treatment of basal cell carcinoma: fundamental and clinical research, innovative
technologies. Different morphological forms of BCC (20 of each morphological form) are
selected for the pathological and IHC evaluation. The obtained study results were presented
as poster in an international congress of EADV and national meeting. The study is in the
process.
National Research Projects
Research Council of Lithuania. Seasonal influenza vaccine effectiveness in hospitalized
patients in Lithuania in 2015-2017 (No. SEN-03/2015). Prof. A. Ambrozaitis, assoc.prof.
L.Jančorienė, B. Zablockienė. 2015 - 2018.
To assess seasonal influenza vaccine effectiveness we are going to perform a hospital-based
case-control study in 18 years and older subjects with influenza-like illness symptoms.
Patients will be swabbed and presence of influenza virus will be confirmed by RT-PCR.
Demographic and clinical information (age, sex, chronic medical conditions, use of antiviral
medication, influenza vaccination status) will be collected in order to identify risk groups
patients. This study will also contribute to the seasonal infleunza vaccination effectiveneess
assessment against the influenza virus (sub)types circulating in Eastern European Region.
International Research Projects
Genetic study of psoriasis with onset in childhood. Prof. M. Bylaitė-Bučinskienė, I.
Šaferienė, Prof. M. Stahle (Karolinska University Hospital, Stockholm, Sweden). 2013-2018.
The aim of the study is to investigate specific biomarkers of patients with onset of childhood
psoriasis (<15 years): to analyze differences between adult onset and children onset of
psoriasis at clinical, immunological and genetic levels. The prospective cohort study will be
carried out in the VU Center of Dermatovenereology in cooperation with Professor Mona
Stahle and her research group at Karolinska Institute Department of Medicine Solna,
Dermatology and Venereology Unit, Karolinska University Hospital, Stockholm, Sweden.
The study is in the process.
Contractual Research
A double-blind, randomized, stratified, multi-center trial evaluating conventional and
high dose oseltamivir in the treatment of immunocompromised patients with influenza.
Assoc.prof. R. Matulionytė.
The aim of this observational study is to evaluate the safety and effectiveness of the
conventional and high dose of oseltamivir in the treatment of immunocompromised patients
with influenza. One patient was enrolled into the study in 2015. The study is in the process.
Clinical and virological outcome of European patients infected with HIV. Assoc. prof. R.
Matulionytė.
This multi-national, multi-center study to determine and evaluate the clinical virological
outcomes of European patients infected with HIV within the frame of Copenhagen HIV
Programme (CHIP), initiated by University of Copenhagen, Faculty of Health Sciences. Total
of 61 patients was enrolled into the sudy in 2015. The study is in the process.
A multicenter, double-blind, randomized withdrawal extension study of subcutaneous
secukinumab in prefilled syringes to demonstrate long-term efficacy, safety and
tolerability up to 2 years in subjects with moderate to severe chronic plaque-type
psoriasis completing preceding psoriasis phase III studies with secukinumab. Prof. M.
Bylaitė-Bučinskienė, T. Karmazienė. 2012 – 2015. Two patients with chronic plaque
psoriasis were included. The study is in continuation.
A phase 3, randomized, double-blind, placebo-controlled study investigating the efficacy
and safety of multiple dupilumab dose regimens administered as monotherapy for
maintaining treatment response in patients with atopic dermatitis. Prof. M. Bylaitė-
Bučinskienė, assoc.prof. J. Grigaitienė, Dr. E. Aukštuolienė. 2015-2018. Four patients were
included, the study is in the process.
Long term clear skin maintenance treatment optimization in patients with moderate to
severe chronic plaque psoriasis: A randomized, multicentre, open-label with blinded-
assessment, comparative, 52 week study to evaluate the efficacy, safety and tolerability
of secukinumab 300 mg. Prof. M. Bylaitė-Bučinskienė, T. Karmazienė, M. Krivickaitė.
2015 – 2018. Two patients are already involved. The study is in the process.
MAIN R&D&I (RESEARCH, DEVELOPMENT AND INOVATION) PARTNERS
Institute of Hepatology, Foundation for Liver Research, London (UK)
Case Western Reserve University, Cleveland, OH (USA)
University of Strasbourg, (France)
Ludwig – Maximilians University, Munich (Germany)
Skåne university hospital, Lund University, Department of occupational and environmental
dermatology (Sweden)
Malmo University (Sweden)
OTHER SCIENTIFIC ACTIVITIES
Prof. A. Ambrozaitis –
chairman of the Lithuanian Society of Infectious Diseases, www.lid.lt;
country representative and member of the European Society of Clinical Microbiology
and Infectious Diseases (ESCMID), www.escmid.org;
member of the European Association of the Study of the Liver, www.easl.ch;
national representative and board member of the Infectious Diseases Section of
European Union of Medical Specialists (UEMS), www.uems.net;
board member of the Baltic Immunoprophylaxis Association, www.baltipa.lt
editor –in-chief of the journal Infekcinės ligos (Infectious Diseases), www.lid.lt
editorial Board member of the journal HIV&AIDS Review: International Journal of
HIV-related Problems, www.journals.elsevier.com/hiv-and-aids-review
editorial board member of the journal Medicinos teorija ir praktika (Theory and
Practice in Medicine), www.mtp.lt;
editorial board member of the journal Sveikatos mokslai (Health Sciences),
www.sam.lt/lt/sam/moksliniai/straipsniai/;
editorial board member of the journal Internistas (Internist), www.medpraktika.lt;
editorial council member of the journal Acta medica Lituanica, www.lmaleidykla.lt;
member of Allergology Commission of Lithuanian Academy of Sciences
(www.lma.lt )
Assoc. prof. R. Matulionytė
chair of the Vilnius Society of Infectious Diseases, www.lid.lt
board member of the Lithuanian Society of Infectious Diseases, www.lid.lt;
member of the European Society of Clinical Microbiology and Infectious Diseases,
www.escmid.org;
member of the European AIDS Clinical Society, www.eacs.ws;
Assoc. prof. L. Jančorienė
member of the European Association of the Study of the Liver, www.easl.ch;
member of the International Society of Travel Medicine, www.istm.org;
member of the Central European Vaccination Awareness Group;
board member of the Lithuanian Society of Infectious Diseases, www.lid.lt;
board member of the Baltic Immunoprophylaxis Association, www.baltipa.lt;
member of the Lithuanian Society of Gastroenterology, www.gastroenterologija.lt.
B.Zablockienė -
member of the Lithuanian Society of Infectious Diseases, www.lid.lt;
member of the European Society of Clinical Microbiology and Infectious Diseases,
www.escmid.org;
member of Lithuanian Society of Pulmonologists; http://www.chest.lt/.
A. Stiklerytė –
member of the European Society of Clinical Virology, www.escv.org;
member of the Lithuanian Society of Infectious Diseases, www.lid.lt.
Prof. E. Danila –
member of European Respiratory Society (ERS); http://www.ersnet.org/
member of Lithuanian Society of Pulmonologists; http://www.chest.lt/
editorial board member of the journal Vaikų pulmonologija ir alergologija
(Children‘s Pulmonology and Allergology);
http://www.pulmonologija.lt/informacija.htm
Prof. R. Dubakienė –
member of European Commission Scientific Committee on Consumer products;
http://ec.europa.eu/health/ph_risk/committees/04_sccp/04_sccp_en.htm
chairman of Allergology Commission of Lithuanian Academy of Sciences;
http://lma.lt/index.php?lang=lt
editor-in-chief of the journal Alergologija ir klinikinė imunologija (Allergology and
Clinical Immunology);
editor-in-chief of the on-line journal Alergologija ir klinikinė imunologija
(Allergology and Clinical Immunology);
editorial board member of the journal Acta Medica Lithuania;
http://www.lmaleidykla.lt/ojs/index.php/actamedicalituanica
editorial board member of the journal Revue of Allergology and Clinical Immunology;
editorial board member of the journal Medicinos teorija ir praktika (Theory and
Practice in Medicine); http://www.mtp.lt/
editorial board member of the journal Immunopathologia;
member of the Lithuanian Immunology Society; www.imcentras.lt/lid/
member of the European Academy of Allergy and Clinical Immunology;
http://www.eaaci.org/
vice-chairman of the Immunology Institute Council of Vilnius University;
head of internet website Alergija, astma, imunologija (Allergy, Asthma, Immunology),
http://www.aai.lt.
Assoc.prof. A. Blažienė –
editorial board member of the journal Medicinos teorija ir praktika (Theory and
Practice in Medicine); http://www.mtp.lt/
chief editor of the journal Alergija, astma, imunologija (Allergy Asthma
Immunology)
member of the European Respiratory Society (ERS); http://www.ersnet.org/
member of the European Academy of Allergy and Clinical Immunology;
http://www.eaaci.org/
member of the American Academy of Allergy, Asthma and Immunology;
http://www.aaaai.org/home.aspx
member of American College of Allergy, Asthma and Immunology;
http://www.acaai.org/Pages/default.aspx
member of European Society of Immunodeficiencies; http://www.esid.org/
member of Lithuanian Society of Immunology; www.imcentras.lt/lid/
member of Lithuanian Society of Pulmonologists. http://www.chest.lt/
Assoc.prof. R. Zablockis –
Chairman of Lithuanian Society of Pulmonologists; http://www.chest.lt/
member of European Respiratory Society (ERS); http://www.ersnet.org/
chief editor of the journal Pulmonology News http://www.chest.lt/
editorial board member of the journal Pulmonology and Allergology
http://www.pulmoalerg.lt/
Dr. L. Malinauskienė –
member of the European Academy of Allergy and Clinical Immunology;
http://www.eaaci.org/
member of Lithuanian society of Allergology and clinical immunology;
http://www.aai.mf.vu.lt/alerimun/draugija.htm
member of European Society for Pigment research; http://www.espcr.org/
Head of the Vilnius Regional Committee for Bioethical research.
http://www.mf.vu.lt/lt/content/vilniaus-regioninio-biomedicininiu-tyrimu-etikos-
komiteto-informacija
Dr. V. Šileikienė –
member of European Respiratory Society (ERS); http://www.ersnet.org/
member of Lithuanian Society of Pulmonologists; http://www.chest.lt/
Head of referential Center of Interstitial lung diseases of Vilnius University Hospital
Santariskiu klinikos http://www.santa.lt/
Dr. V. Kvedarienė –
editorial board member of the journal Pulmonologija, imunologija ir alergologija
(Pulmonology, immunology and allergolgy);
vice-chairman of rewever board of the journal Vaikų pulmonologija ir alergologija
(Children‘s Pulmonology and Allergology);
http://www.pulmonologija.lt/informacija.htm
member of Allergology Commission of Lithuanian Academy of Sciences;
http://lma.lt/index.php?lang=lt
member of the European Academy of Allergy and Clinical Immunology;
http://www.eaaci.org/
member of UCB Institute of Allergy, http://www.theucbinstituteofallergy.com/Home
member of Lithuanian Society of Allergology and Clinical Immunology,
http://www.aai.mf.vu.lt/alerimun/draugija.htm
member of Allergic Rhinitis and its Impact on Asthma (ARIA)
http://www.whiar.org/
member of European Network on Drug Allergy (ENDA);
member of Integrated Care Pathways for Airways Diseases (AIRWAYS-ICPs)
http://macvia.cr-languedocroussillon.fr/index.php/en/whoarewe
medical advisor of Lithuania Asthma Patient Association.
http://www.chest.lt/lietuvos-astmos-klubu-asociacija
R. Aleksonienė –
member of European Respiratory Society (ERS); http://www.ersnet.org/
member of Lithuanian Society of Pulmonologists; http://www.chest.lt/
Assoc.prof. habil. dr. R.Janilionis -
board member of the Lithuanian Society of Cardiothoracic Surgery; www.lkscd.lt
board member of Vilnius Surgical Society;
member of European Respiratory Society (ERS) www.ersnet.org.
member of the European Association for Cardio-Thoracic Surgery. www.eacts.org.,
editorial board member of the journal „Medicina“; www.medicina.kmu.lt
editorial boad member of the journal „Lithuanian Surgery“. http://www.chirurgija.lt
Assoc.prof. dr.V. Gruslys –
member of Lithuanian Society of Thoracic and Cardiac Surgeons; www.lkscd.lt
member of European Respiratory Society (ERS); www.ersnet.org
board member of Lithuanian Society of Minimal Invasive Surgery;
http://www.mic.lt
member of Lithuanian Respiratory Society. http://www.chest.lt
Assistant professor Ž. Jagelavičius –
member of Lithuanian Society of Thoracic and Cardiac Surgeons; www.lkscd.lt
member of European Society of Thoracic Surgeons (ESTS).www.ests.org.
member of European Respiratory Society (ERS). www.ersnet.org
Prof. M. Bylaitė –
president of the Lithuanian Society of Dermatovenereology; www.ldvd.lt;
board member of the European Academy of Dermatology and Venereology,
www.eadv.org;
board member of the European Association of Dermatooncology, www.eado.org;
board member of the Baltic association of Dermatovenereologists;
http://www.conferencelithuania.eu
national representative and board member of the Dermato-Venereology Section of
European Union of Medical Specialists (UEMS), www.uems.net;
member of the European Dermatology Forum, www.euroderm.org;
member of the European Society for Pediatric Dermatology (ESPD) www.espd.com;
member of the International Society of Dermatology, www.intsocderm.org;
board member of the Euro-Asian Association of Dermatovenerologists
www.eaad.com
editorial board of the Journal of Health Sciences http://jhs.pharm.or.jp/
Assoc.prof. J. Grigaitienė –
member of the Lithuanian Society of Dermatovenereology; www.ldvd.lt
member of the Lithuanian Society of Allergology and Clinical Immunology;
http://www.eaaci.org/
member of the Lithuanian Society of Lasers; http://www.lazerineklinika.lt/en/
member of the Baltic Society of Dermatovenereology. http://www.eadv.org/
Assoc.prof. R. Gancevičienė –
board member of the Lithuanian Society of Dermatovenereology; www.ldvd.lt
member of the European Academy of Dermatology and Venereology, www.eadv.org;
member of the Baltic Society of Dermatovenereology. http://www.eadv.org/
member of the International Federation of Societies of Cosmetic Chemists.
http://www.ifscc.org/
I. Balčiūnienė –
member of the Lithuanian Society of Dermatovenereology; www.ldvd.lt
member of the Baltic Society of Dermatovenereology. http://www.eadv.org/
T.Karmazienė –
member of the Lithuanian Society of Dermatovenereology; www.ldvd.lt
member of the Baltic Society of Dermatovenereology. http://www.eadv.org/
I.Kisielienė –
member of the Lithuanian Society of Dermatovenereology; www.ldvd.lt
member of the Baltic Society of Dermatovenereology. http://www.eadv.org/
NEUROLOGY AND NEUROSURGERY CLINIC
Santariškių str. 2, LT-08661 Vilnius
Tel. +370 688 62744, fax. +370 688 62728
E-mail: [email protected]
Head – Prof. Dr. Dalius Jatužis
STAFF
Professors: Dr. D. Jatužis; Dr. G. F. Kaubrys.
Assoc. professors: Dr. R. Mameniškienė, Dr. S. Ročka; Dr. K. Laurikėnas.
Lecturers: Dr. K. Ryliškienė; Dr. R. Kvaščevičius; Dr. R. Kaladytė-Lokominienė, Dr. G.
Terbetas, Dr. J. Valaikienė, Dr. A. Vilionskis, Dr. R. Kizlaitienė.
Senior research fellows: Habil. dr. V. Gaigalaitė.
Junior research fellows: Dr. A. Klimašauskienė; A. Preikšaitis, Ž. Chomanskis
Doctoral students: N. Giedraitienė; I. Sereikė; D. Valadkevičienė, E. Sakalauskaitė-
Juodeikienė, M. Kurminas.
RESEARCH INTERESTS
Cognitive disorders in neurodegenerative, cerebrovascular, demyelinating diseases and
epilepsy
Assessment and practical application of new diagnostic and treatment methods in stroke and
cerebrovascular disease, demyelinating, neurodegenerative diseases, epilepsy and migraine
Diagnostic evaluation and treatment of cerebrovascular disorders, traumatic brain injuries,
degenerative spinal diseases and cerebral neoplasms
Center of Neurology continued clinical research focussed on clinical and cognitive
characteristics of different neurological disorders (Alzheimer's disease, multiple sclerosis,
Parkinson's disease, epilepsy); assessment and practical application of new diagnostic and
treatment methods in cerebrovascular, demyelinating, neurodegenerative diseases, epilepsy
and migraine; evaluation of neurophysiological and clinical peculiarities of patients with
critical illness; depiction of nervous system disorders and mental diseases in historical
documents related to Vilnius and Vilnius university.
Center of Neuroangiosurgery is establishing new methods of endovascular treatment of
cerebrovascular disorders. Research in traumatic brain injury is concentrated to epidemiology
and prognostic factors, as well as clinical evaluation of new monitoring devices. New
modalities in minimally invasive degenerative spinal diseases management are being
evaluated. Research in cerebral neoplasms is based on epidemiological studies and evaluation
of new strategies of surgical treatment.
RESEARCH PROJECTS CARRIED OUT IN 2015
Projects Supported by University Budget
Assessment of new diagnostic and treatment methods in neurology and neurosurgery
(cerebrovascular, neurodegenerative, oncological, demyelinating diseases, epilepsy,
traumatic injury, degenerative spinal diseases). Prof. D. Jatužis. 2014 – 2018.
Center of Neurology continued clinical research focussed on clinical and cognitive
characteristics of different neurological disorders (Alzheimer's disease, multiple sclerosis,
Parkinson's disease, epilepsy); assessment and practical application of new diagnostic and
treatment methods in cerebrovascular, demyelinating, neurodegenerative diseases, epilepsy
and migraine; evaluation of neurophysiological and clinical peculiarities of patients with
critical illness; description of artworks related to neurology and artists with neurological
disorders.
Main publications:
1. Rotomskis A, Margevičiūtė R, Germanavičius A, Kaubrys G, Budrys V, Bagdonas A.
Differential diagnosis of depression and Alzheimer's disease with the Addenbrooke's
Cognitive Examination-Revised (ACE-R). BMC Neurol. 2015; 15: 57.
2. Kuzmickienė J, Kaubrys G. Selective Ability of Some CANTAB Battery Test
Measures to Detect Cognitive Response to a Single Dose of Donepezil in Alzheimer
Disease. Med Sci Monit. 2015; 21: 2572-82.
3. Giedraitiene N, Kaubrys G, Kizlaitiene R, Bagdonaite L, Griskevicius L, Valceckiene
V, Stoskus M. Therapeutic Plasma Exchange in Multiple Sclerosis Patients with
Abolished Interferon-beta Bioavailability. Med Sci Monit. 2015; 21: 1512-9.
Diagnostic evaluation and treatment of cerebrovascular disorders, traumatic brain
injuries degenerative spinal diseases and cerebral neoplasms. Assoc. Prof. S.Ročka 2011-
2016
Center of Neuroangiosurgery is establishing new methods of endovascular treatment of
cerebrovascular disorders. Research in traumatic brain injury is concentrated to epidemiology
and prognostic factors, as well as clinical evaluation of new monitoring devices. New
modalities in minimally invasive degenerative spinal diseases management are being
evaluated. Research in cerebral neoplasms is based on epidemiological studies and evaluation
of new strategies of surgical treatment.
Main publications:
1. Maas AIR, Menon DK, Steyerberg EW, Citerio G, Lecky F, Manley GT, Hill S, Legrand
V, Sorgner A, on behalf of the CENTER-TBI Participants and Investigators (see
Appendix) [Rocka S, Preiksaitis A]. Collaborative European NeuroTrauma Effectiveness
Research in Traumatic Brain Injury (CENTER-TBI): A Prospective Longitudinal
Observational Study // Neurosurgery 2015; 76(1):67–80.
2. Rackauskas A, Lapteva O, Rocka S. Timing of surgery for neurologically compromised
traumatic cervical spine injuries // J Neurol Surg A Cent Eur Neurosurg 2015 Oct 7 [Epub
ahead of print] – Part A. DOI http://dx.doi.org/ 10.1055/s-0035-1564052. ISSN 2193-
6315.
3. Balseris S, Strazdas G, Ročka S, Jakštas T. Endoscopic Endonasal Approach of
Congenital Meningoencephalocele Surgery: First Reported Case in Lithuania // Case
Reports in Otolaryngology, Hindawi Publishing Corporation Volume 2015, Article ID
728561, 5 pages http://dx.doi.org/10.1155/2015/728561.
National Research Projects
National Science Program “Healthy Ageing”, Project SEN-05/2015 Research on synthesis
regulation of proteins, associated with the development of Alzheimer’s disease in
cooperation with the Vilnius University Institute of Biotechnology. Prof. G. Kaubrys.
Analysis of Braing Tumors Prognostic Factors and Early Response with Visual
Biomarkers in cooperation with National Cancer Institute (No. MIP-015/2014; KT2014-
27). Assoc. prof. S. Ročka.
Clinical research Impact of modified lindy-hop dance therapy on motor condition and
quality of life in early Parkinson's Disease in collaboration with Vilnius Gediminas
Technical University. Lect. R. Kaladytė Lokominienė.
Lithuanian High Cardiovascular Risk Programme. Prof. D. Jatužis.
Laucevičius A, Rinkūnienė E, Skujaitė A, Petrulionienė Ž, Puronaitė R, Dženkevičiūtė V,
Kasiulevičius V, Jatužis D, Ryliškytė L, Šlapikas R. Prevalence of cardiovascular risk factors
in Lithuanian middle-aged subjects participating in the primary prevention program, analysis
of the period 2009-2012. Blood Press. 2015; 24(1): 41-7.
International Programmes, Projects and Contracts
SITS (Safe Implementation of Treatments in Stroke).
SITS is an academic-driven, non-profit, international collaboration with a base at Karolinska
Institutet in Sweden. It is an initiative by the medical profession to accelerate clinical trials
and to certify excellence in acute and secondary prevention stroke treatment. The SITS
Network includes a broad range of hospitals. SITS centres are therefore representative of
normal stroke care facilities, i.e. not only expert centres or very advanced centres. SITS has
engaged leading stroke scientists as National Coordinators in each participating country.
Related projects: SITS-EAST and ESO-SITS.
Main publication:
Tsivgoulis G, Kadlecová P, Kobayashi A, Czlonkowska A, Brozman M, Švigelj V, Csiba L,
Kõrv J, Demarin V, Vilionskis A, Jatuzis D, Katsanos AH, Rudolf J, Krespi Y, Mikulik R.
Safety of Statin Pretreatment in Intravenous Thrombolysis for Acute Ischemic Stroke. Stroke.
2015; 46: 2681-4.
SITS-EAST started as a study of implementation of evidence-based stroke therapy supported
by the SITS International Registry. The study was initiated in autumn 2007 with the support
of European Grant. It is now ongoing registry for the documentation and immediate statistical
evaluation of stroke management in Eastern Europe.
Main publication:
Karlinski M, Kobayashi A, Czlonkowska A, Mikulik R, Vaclavik D, Brozman M, Gdovinova
Z, Švigelj V, Csiba L, Fekete K, Kõrv J, Demarin V, Bašic-Kes V, Vilionskis A, Jatuzis D,
Krespi Y, Shamalov N, Andonova S, Ahmed N, Wahlgren N; Safe Implementation of
Treatments in Stroke–East Registry (SITS-EAST) Investigators. Intravenous Thrombolysis
for Stroke Recurring Within 3 Months From the Previous Event. Stroke. 2015; 46: 3184-9.
ESO – SITS started as project with aim to estimate the quality of stroke service in East and
Central Europe. The study was initiated in 2015. It is now developing questionnaire for the
documentation of quality of stroke service in Central and Eastern Europe.
EuroHYP-1
The EuroHYP-1 trial is a pan-European, open, randomised, phase III clinical trial which will
assess the benefit of therapeutic cooling in adult patients with acute ischaemic stroke. In
addition to efficacy and safety, the economic impact of therapeutic hypothermia will be also
evaluated. The EuroHYP consortium brings together leading European experts in statistical
design and analysis, therapeutic hypothermia, imaging, health economics, ultrasound,
biomarkers, and trial execution (implementation and monitoring) as well as European patient
and family advocacy groups and Small and Medium-size Enterprises.
The Standardised Computer-based Organised Reporting of EEG (SCORE)
The aim of the project was to create a computer-based system for EEG assessment and
reporting. The faculty was approved by the Commission on European Affairs of the ILAE.
The working group produced a consensus proposal that went through a pan-European review
process, organized by the European Chapter of the International Federation of Clinical
Neurophysiology. SCORE software was constructed based on the terms and features of the
consensus statement and it was tested in the clinical practice.
Current status of epilepsy health care for adult patients from central and eastern
European Union countries
The aim of this survey was to review and compare the current approaches to epilepsy
management in central and eastern EU countries. Experts from Bulgaria, Czech Republic,
Estonia, Hungary, Latvia, Lithuania, Poland, Romania, Slovakia, and Slovenia participated in
the project, focused on the epilepsy treatment of adults. We concluded that the lack of unified
procedures pertaining to the evaluation and therapy of epilepsy is reflected by marked
differences in access to treatment modalities for patients from CEEU countries.
Main publication:
Mameniskiene R, Sakalauskaite-Juodeikiene E, Budrys V. People with epilepsy lack
knowledge about their disease. Epilepsy Behav. 2015; 46: 192-7.
International Multicenter Register: European Register of Antileptic Drugs and
Pregnancy (EURAP)
Tomson T, Battino D, Bonizzoni E, Craig J, Lindhout D, Perucca E, Sabers A, Thomas SV,
Vajda F; EURAP Study Group (R.Mameniskiene). Dose-dependent teratogenicity of
valproate in mono- and polytherapy: an observational study. Neurology. 2015; 85(10): 866-
72.
International register of the treatment of refractory status epilepticus
International project on the EEG changes during the olfactory stimulation in patients
with epilepsy
Cochrane Neurological Network: Systematic Reviews and Metaanalysis in Neurology
MAIN R&D&I (RESEARCH, DEVELOPMENT AND INOVATION) PARTNERS
Kaunas University of Technology (Lithuania)
National Cancer Institute (Lithuania)
Vilnius Gediminas Technical University (Lithuania)
Karolinska Institutet, Stockholm (Sweden)
Dianalund Epilepsy Centre (Denmark)
University of Regensburg, Department of Neurology/ Stroke Unit/Neurovascular Laboratory
(Germany)
OTHER SCIENTIFIC ACTIVITIES
Prof. D. Jatužis -
President of the Lithuanian Stroke Association and Lithuanian Neurological
Association
educational co-ordinator of World Federation of Neurology (WFN) for Lithuania
delegate of Lithuania for the European Academy of Neurology (EAN)
executive editor of the journal Neurologijos seminarai (Seminars in Neurology)
fellow member of European Stroke Organization (FESO), member of ESO Trials
Network Committee
national coordinator of ESO-EAST “Enhancing and Accelerating Stroke Treatment”
(5-year collaboration with selected physicians from Eastern countries to optimise
stroke care in Eastern Europe)
national Coordinator in SITS (Safe Implementation of Treatments in Stroke) and
member of SITS-EAST
lead Investigator in EuroHYP-1 trial
Prof. G. Kaubrys -
member of Subspecialty Scientific panel “Dementia and cognitive disorders” of the
European Academy of Neurology (EAN)
member of Subspecialty Scientific panel “Higher cortical functions” of the European
Academy of Neurology (EAN)
voting member of the Association for the Scientific Study of Consciousness
editor-in-chief of the Journal Neurologijos seminarai (Seminars in Neurology)
member of the Council of the Lithuanian Neurological Association
Assoc. Prof. R. Mameniškienė -
President of Lithuanian Society for epileptology
member of the Council of the Lithuanian Neurological Association
editor-in-chief of the journal Nervų ir psichikos ligos
national Coordinator in European Register of Antileptic Drugs and Pregnancy
(EURAP)
national Coordinator in the international registry of the treatment of refractory status
epilepticus
Assoc. Prof. S. Ročka -
member of Lithuanian Neurosurgical Society
member of Brain IT group
member of European association of Neurosurgical societies
member of World Federation of Neurosurgical Societies
member of Lithuanian Neuroscience association
Assoc. Prof. K. Laurikėnas -
editorial board member of the journal Chirurgija (Surgery)
member of the Lithuanian society of Vascular surgery
Lect. Dr. R. Kvaščevičius
member of Lithuanian Neurosurgical Society
member of Baltic Neurosurgical Association
member of European Association of Neurosurgical Societies
member of World Federation of Neurosurgical Societies
member of Lithuanian society of vertebrology
Lect. Dr. G. Terbetas -
member of Lithuanian Neurosurgical Society
member of Lithuanian society of vertebrology
AOSpine member
Lect. R. Kaladytė-Lokominienė -
member of the Council of Lithuanian Neurological Association
member of Movement Disorders Scientific Panel of European Academy of Neurology
member of International Parkinson's Disease and Movement Disorders Society
member of Cochrane Collaboration Neurological Network
coordinator of Huntington's Disease Coordination Centre
Lect. K. Ryliškienė -
member of the Board of Nordic Stroke Society
head of Neurology Panel of Students Research Society of Vilnius University Medical
Faculty
member of international Arterial measurements collaboration
Lect. A. Vilionskis -
member of council of the Lithuanian Stroke Association
member of the Lithuanian Neurological Association
fellow member of ESO (European Stroke Organisation)
national Coordinator in SITS (Safe Implementation of Treatments in Stroke) and
member of SITS-EAST
Lect. J. Valaikienė -
member of the Lithuanian Association of Neurology
member of the Lithuanian Stroke Association
member of Lithuanian Society of Clinical Physiology
member of the European Academy of Neurology (EAN) Scientific Panel of
Neurosonology
member of the EAN Scientific Panel of Infectious diseases
member of the World Federation of Neurology
INSTITUTE OF ODONTOLOGY
115 Žalgirio, LT-08217 Vilnius
Tel. 272 7589, fax 272 8569
E-mail: [email protected]
Head - Prof. Dr. Vytautė Pečiulienė
STAFF
Professors: Dr. (HP) A. Pūrienė; Dr. V. Pečiulienė
Associate professors: Dr. R. Manelienė, Dr. L. Zaleckas (part-time), Dr. V. Rutkūnas, Dr. E.
Miliūnienė, Dr. S. Drukteinis, Dr. V. Brukiene, Dr. L. Linkevičienė, Dr. T. Linkevičius, Dr.
R. Bendinskaitė,
Lecturers: Dr. D. Ivanauskaitė (part-time)
Assistants: Dr. J. Rimkuvienė, Dr. K. Sveikata (part-time), V. Almonaitis (part-time), R.
Pletkus (part-time), A. Rimkevičius (part-time), J. Žekonienė (part-time), R. Trumpaitė-
Vanagienė (part-time), R. Rasteniene (part-time), P. Kalesinskas (part-time), V. Zaleckiene
(part-time), D.Janavičiene (part-time), G.Grigaite (part-time)
Doctoral students: P. Kalesinskas, V. Janulytė, L.Džiaugytė, I.Gendvilienė
RESEARCH INTERESTS
Oral Health and Treatment Needs of Patients with Haemophilia A and B in Lithuania
Management of traumatic dental injuries: a survey of Lithuanian dentists. Prevalence of
traumatic injuries to the permanent front teeth among 6th grade Lithuanian schoolchildren in
Vilnius city
Specialities of medical services and management of patients with odontogenic maxillofacial
infections in Lithuania
Lichen planus patients with clinical indicators and their relations with the social and lifestyle
risk factors and subjective assessment of life quality
The supply and requirement for dentists and dental specialists in Lithuania. Planning
projections
The quality of life of the retirement-age dentists in Lithuania
Complications associated with dental implants
Long term ortodontic treatment results, stability, complications, patients self evaluation
Traditional and digital implant impression techniques. Evaluation and comparison of
accuracy
Biocompatibility of prosthetic materials in implant prosthodontics
CAD/CAM and other digital technologies to improve treatment protocols in prosthodontics
Prospective randomised long term three centre study of the Baltic Cleft Network (Rostock,
Germany; Ryga, Latvia and Vilnius, Lithuania. Influence of the surgical technigues and
orthodontical treatment on facial growth of cleft patient
Prevention of Dental Caries Using Antisense Oligonucleotides to Glucosyltransferases of
Mutans Group Streptococci
Prevalence and etiology of facial bone fractures in Lithuania
Theory based oral hygiene education in adolescents
Salivary factors and caries in family members
Marginal fit of fixed prostheses and its influence on the periodontal tissues
Construction of composite bone scaffold material and in vivo evaluation of biocompatibility
and osteopromotion
Oral health and treatment needs of children with cerebral palsy in Vilnius city
Psychological preparation for dental procedures of children with autism spectrum disorders:
assessment of possibilities
RESEARCH PROJECTS CARRIED OUT IN 2015
Projects Supported by University Budget
Evaluation of prevalence, treatment methods modalities, rehabilitation and prevention
of patients with congenital and acquired diseases of stomatognatic system. Prof. Vytautė
Pečiulienė 2014-2018.
The aim of the project is to evaluate: the prevalence of congenital and acquired stomatognatic
system diseases and to select the most effective methods of treatment and prevention, attitude
of patients and dentists towards the quality of dental treatment procedures, dental health
behaviour modification in adolescents, and the dental fear. This project overwhelms different
scientific fields which are devoted to different topics in odontology.
Main publications:
1. Rastenienė R, Aleksejūnienė J, Pūrienė A. Dental treatment needs and health care-
seeking behaviours of patients with acute odontogenic infections in Lithuania. Int
Dent J. 2015 Aug; 65(4):188-95.
2. Rutkunas V, Bukelskiene V, Sabaliauskas V, Balciunas E, Malinauskas M,
Baltriukiene D. Assessment of human gingival fibroblast interaction with dental
implant abutment materials. J Mater Sci Mater Med. 2015 Apr; 26(4):169
3. Aleksejūnienė J, Brukienė V, Džiaugytė L, Pečiulienė V, Bendinskaitė R. A theory-
guided school-based intervention in order to improve adolescents' oral self-care: a
cluster randomized trial. Int J Paediatr Dent 2015 Apr 16.
National Research Projects
Lithuanian Research Council. Construction of composite bone scaffold material and in
vivo evaluation of biocompatibility and osteopromotion (No MIP-15552).
MAIN R&D&I (RESEARCH, DEVELOPMENT AND INOVATION) PARTNERS
Center for Physical Sciences and Technology (Lithuania)
University of British Columbia (Vancouver, Canada)
Institute of Biotechnology Vilnius university (Lithuania)
Institute of Biochemistry, Vilnius University (Lithuania)
Laser Research Center, Vilnius University (Lithuania)
OTHER SCIENTIFIC ACTIVITIES
Prof. V. Pečiulienė –
editorial board member of the journal Stomatologija (Dentistry); Euroepan Journal
of General Dentistry, Acta Medica Lituanica
Prof. A. Pūrienė –
editorial board member of the journal Stomatologija (Dentistry); Dental and Medical
Problems; Quintessence International Lietuva;Health Sciences
Doc. V. Rutkūnas –
editorial board member of the journal Stomatologija (Dentistry);
vice-president of organizing committee of international conference „Prevention of
complications in prosthetic dentistry“ http://lood.lt/lt/2015_m_konferencija/
Doc. V. Brukienė –
editorial board member of the journal Stomatologija (Dentistry); Quintessence
International Lietuva; “Slauga. Mokslas ir praktika”
J. Rimkuvienė –
editorial board member of the journal Stomatologija (Dentistry);
doc. S. Drukteinis –
editorial board member of the journal Quintessence International Lietuva
lect. L. Linkevičienė –
editorial board member of the journal Quintessence International Lietuva
Lect. R.Bendinskaitė –
editorial board member of the journal Quintessence International Lietuva
J. Žekonienė –
editorial board member of the journal Quintessence International Lietuva
DEPARTMENT OF PATHOLOGY, FORENSIC MEDICINE AND
PHARMACOLOGY
M. K. Čiurlionio str. 21, LT-03101 Vilnius
Tel. +370 239 8727
E-mails: [email protected]; [email protected]
Head – Prof. Dr. Virginija Grabauskienė
Interfaculty Laboratory of Research the biological active substances
29 a Geležinio Vilko, Vilnius
Tel +370 239 8992
Email: [email protected]
Head – Prof. Habil. Dr. Rūta Dubakienė
STAFF
Professors: Dr. A. Laurinavičius, Habil. Dr. V. Basys, Habil. Dr. R. Dubakienė, Dr. V.
Grabauskienė, Dr. D. Characiejus.
Associate professors: Dr. A. Jasulaitis, Dr. D. Vaitkienė. Dr. J. Gulbinovič, Dr. A.
Laurinavičienė, Dr. A. Barakauskienė, Dr. E. Žurauskas, Dr. J. Kasnauskienė, Dr. E.
Kazėnaitė.
Lecturers: Dr. M. Balčiūnas, Dr. K.Ivanauskas, V. Baltrūnienė, D.Linkevičiūtė, S.
Budrikienė, R. Dzetaveckienė, Dr. K. Garuolienė, D. Petroška, A. Gintautas, A. Šimbelytė.
Assistants: U. Mickys, T. Baltrūnas, R. Katkus, I. Lisauskienė, J.Stasiūnienė, J. Drachneris,
J.Bublevič, G. Rimeika.
Research fellows: Dr. D.Bironaitė (part-time).
Doctoral students: S. Laima, I. Lisauskienė , V. Rutkauskaitė, S. Mažeikienė, J.
Besusparis, A. Šimbelytė, V. Baltrūnienė, S. Chmieliauskas, D. Žilėnaitė
RESEARCH INTERESTS
Development of the new diagnostic and prognostic molecular markers and tools for their
quantification in the tissues. Diagnostic value of pathology tests and efficiency of cancer
prevention programs
Development of the predictive, preventive, personilize and prognostic biomarkers of the
diseases
The molecular mechanisms of the allergic diseases formation among Lithuanian population,
development of new diagnostic and treatment strategies
Genesis and gnoseology of violence
Utilization of cardiovascular medications and impact on changes in cardiovascular mortality
and morbidity in Lithuania
RESEARCH PROJECTS CARRIED OUT IN 2015
Projects Supported by University Budget
Development of the new diagnostic and prognostic molecular markers for major
disease. Diagnostic value and Clinico-Pathologic Correlations of the pathological tests.
Prof. A. Laurinavičius. 2014 - 2018.
The selected new molecular biomarkers of major disease can help more precisely predict the
course of the disease and allow the use of the most appropriate treatment, thereby reducing
the number of unnecessary radical interventions and improving patients' quality of life.
Identification and validation of such biomarkers will allow expanding range of non-invasive
disease prognosis methods. The integration of mathematical theories to the domain of human
pathology diagnosis in terms of methodology, quantitative analysis, and added value of newly
developed tissue heterogeneity metrics.
Main publications:
1. Pavyde E, Maciulaitis R, Mauricas M, Sudzius G, Didziokiene EI, Laurinavicius A,
Sutkeviciene N, Stankevicius E, Maciulaitis J, Usas A: Skeletal muscle-derived
stem/progenitor cells: A potential strategy for the treatment of acute kidney injury.
Acta Physiologica 2015;215:8-9.
2. Maciulaitis J, Deveikyte M, Rekstyte S, Bratchikov M, Darinskas A, Simbelyte A,
Daunoras G, Laurinaviciene A, Laurinavicius A, Gudas R, Malinauskas M,
Maciulaitis R: Preclinical study of sz2080 material 3d microstructured scaffolds for
cartilage tissue engineering made by femtosecond direct laser writing lithography.
Biofabrication 2015;7
3. Kantauskaite M, Laucyte-Cibulskiene A, Miglinas M, Laurinavicius A:
Histopathological classification for the prediction of renal outcome in crescentic
glomerulonephritis. Nephrology Dialysis Transplantation 2015;30
Development of the predictive, preventive, personilize and prognostic biomarkers of the
diseases. Prof. V. Grabauskienė, Prof. D. Characiejus. 2014 - 2018.
The use of the new biomarkers has evolved in a better identification of the aetiology and
pathophysiology of the disease and development of novel treatment strategies. We are
searching new immunohistochemical and molecular biology biomarkers for diagnosis,
prognosis and disease progression of dilated cardiomyopkathy and for patient selection for
novel aetiology-directed treatment strategies. We evaluate the clinical potential of titin
ligands in monitoring progression of cardiac remodeling associated with end-stage IDCM.
We investigate mechanisms of parvoB19 virus damages on mice cardiomyocites. Also we
investigate the prognostic and predictive biomarkers in cancer patients with special attention
on T lymphocytes which are most important payers of the control of neoplastic disease.
Main publications:
1. Sudžius, Gintaras, Mieliauskaitė, Diana, Šiaurys, Almantas, Vilienė, Rita, Butrimienė,
Irena, Characiejus, Dainius, & Dumalakienė, Irena. (2015). Distribution of peripheral
lymphocyte populations in primary Sjögren’s syndrome patients. Journal of
Immunology Research, 2015, 1-10.
2. Bironaite D, Daunoravicius D, Bogomolovas J, Cibiras S, Vitkus D, Zurauskas E,
Zasytyte I, Rucinskas K, Labeit S, Venalis A, Grabauskiene V. Molecular
mechanisms behind progressing chronic inflammatory dilated cardiomyopathy. BMC
Cardiovascular Disorders (2015)15:26.
3. Bogomolovas J, Brohm K, Čelutkienė J, Balčiūnaitė G, Bironaitė D, Bukelskienė V,
Daunoravičius D, Witt C C, Fielitz J, Grabauskienė V, Labeit S. “Induction of
Ankrd1 in Dilated Cardiomyopathy Correlates with the Heart Failure Progression,”
BioMed Research International, vol. 2015, Article ID 273936, 9 pages, 2015.
Genesis and Gnoseology of Violence. Doc. A. Jasulaitis. 2014 - 2018.
Comparative analysis of 1422 cases of violence of children against children was carried out,
with particular emphasis on distribution causes and consequences. Most children suffer from
different types of violence, while the most common type of violence is physical violence. A
trend towards decrease of violence against children was determined. However, it has to be
pointed out that determination of cases of violence may not be adequate, because information
is not complete in all cases.
Main publications:
1. Laima S, Fomin D, Jasulaitis A, Bareikytė A, Banionis D, Andriuškevičiūtė G,
Chmieliauskas S. (2015). Psichologinės ir somatinės streso išraiškos, jų paplitimas.
Laboratorinė Medicina, 17(3), 110-114.
2. Pūras D, Laima S, Jasulaitis A, Andriuškevičiūtė G, Chmieliauskas S. (2015). The
forensic medical assessment of psychological and physical violence experienced by
children. Journal of Chemical, Biological and Physical Sciences, 1566-1573.
3. Stasiūnienė J, Justickis V, Jasulaitis A. (2015). Newborn murder and its legal
prevention. Sveikatos Politika Ir Valdymas, (1), 91-119.
The molecular mechanisms of the allergic diseases formation among Lithuanian
population, development of new diagnostic and treatment strategies. Prof. R.
Dubakiene. 2008–2016.
Lithuania have been determined, the most common food allergens were assessed and
changes in prevalence of sensitization to them during first 30 months of life were
analyzed, also the role of possible determinants for the development of food allergies,
such as genetic background, maternal diet during pregnancy and breastfeeding, way of
birth, infections, medicines, psycho-social and environmental factors, were examined
and different food allergy diagnostic methods were evaluated. According the data
results, guidelines for food allergy diagnosis in small children have been provided.
Main publications:
1. Xepapadaki P, Fiocchi A, Grabenhenrich L, Roberts G, Grimshaw KEC, Fiandor A,
Larco JI, Sigurdardottir S, Clausen M, Papadopoulos LNG, Dahdah L, Mackie A,
Sprikkelman AB, Schoemaker AA, Dubakiene R, Butiene I, Kowalski ML, Zeman K,
Gavrili S, Keil T, Beyer K. Incidence and natural history of hen's egg allergy in the
first 2 years of life - the EuroPrevall birth cohort study. Allergy 2015;
2. Bousquet J, Schunemann HJ, Fonseca J, Dubakiene R et al. MACVIA-ARIA Sentinel
NetworK for allergic rhinitis (MASK-rhinitis): the new generation guideline
implementation. Allergy 2015; 70: 1372–1392.
Utilization of cardiovascular medications and impact on changes in cardiovascular
mortality and morbidity in Lithuania. Prof. V. Basys, Dr. J. Gulbinovič. 2014-2018
Main publication:
Lisauskienė I, Garuolienė K, Gulbinovič J. (2014). Trends and pattern of the utilization
of cardiovascular medicines in Lithuania in 2003-2012. Acta Medica Lituanica, 21(3),
129-136.
National Research Projects
Research Council of Lithuania. Significance of titin ligands MuRF and CARP in dilated
myocardium -TiMuC A (No. MIP-011/2014). Prof. V. Grabauskienė. 2014 – 2016.
Dilated cardiomyopathy (DCM) is the most common cause of the heart failure. The only
treatment for advanced or therapy-resistant end-stage DCM is heart transplantation.
Therefore, the need for new, cost –effective DCM treatment and diagnostic tools is
particularly acute in modern cardiology. However, the poor understanding of underlying
molecular mechanisms is inhibiting development of such tools. Most of the insights into the
molecular development and progression mechanisms of cardiomyopathy come from the
animal model research, that do not always reflect the processes occurring in the human body.
In this work we plan to investigate the relationship between the expression of two titin (a
protein that organize sarcomere) ligands and the myocardial injury in mice experimental
autoimmune myocarditis (EAM) model and standardized DCM patient cohort. We would
focus on the titin associated ubiquitin ligases MuRF1 and MuRF2 and the stress response
protein CARP (Cardiac Ankyrin Repeat Protein). Using DCM patient heart biopsies, we will
assess how the expression of studied proteins correlate with the nature and severity of
myocardial injury. We shall investigate causative links between studied proteins and by
comparing wildtype mice with MuRF and CARP knock-out mice during the EAM/DCMP.
Mouse model studies will assess whether titin ligands might be new molecular targets for
treatment, diagnosis and prevention of DCM. Pilot study of patient heart biopsies have shown
that CARP expression correlates with the severity of myocardial injury in DCM patients. This
study due to the cooperation between medical doctors and biologists will combine clinical
and experimental aspects of dilated cardiomyopathy. Obtained results will create a scientific
basis for further research on molecular pathogenesis of human DCM and the search for new
therapeutic targets
Main publications:
1. Bogomolovas J, Brohm K, Čelutkienė J, Balčiūnaitė G, Bironaitė D, Bukelskienė V,
Daunoravičius D, Witt C C, Fielitz J, Grabauskienė V, Labeit S. “Induction of Ankrd1
in Dilated Cardiomyopathy Correlates with the Heart Failure Progression, BioMed
Research International, vol. 2015, Article ID 273936, 9 pages, 2015.
2. Bogomolovas J; Šimoliūnas E, Rinkūnaitė I, Smalinskaitė L, Podkopajev A, Bironaitė
D, Bukelskienė V, Grabauskienė V, Cleo-Aron Weis, Marx A, Gretz N, Labeit D,
Labeit S. A novel murine model of parvovirus associated dilated cardiomyopathy
induced by immunization with VP1-unique region of parvovirus B19. In print Journal
of Cardiac Failure, 2015.
Research Council of Lithuania. Bioluminescence imaging of lymphocytes in antitumour
reactions (No. MIP-046/2013. Prof. Dainius Characiejus. 2013 - 2015
Methods of optical imaging open new avenues for studies of immune antitumour reactions.
The aim of this project was to investigate the lymphocyte migration and proliferation in vivo
using bioluminescence imaging equipment and to determine whether these properties of
lymphocytes are related to their antitumour effect. Sensitized T lymphocytes from transgenic
luciferase-expressing β-actin-luc mice rejected allogeneic SL2 tumors in RAG-/-
mice. After
rejection of primary SL2 tumor, RAG-/-
mice were able to reject second rechallenge.
Lymphocytes could be tracked in vivo using bioluminescence imaging. Rejection of the
rechallenged tumor was associated with lymphocyte proliferation and migration to the tumor
site.
Main publication:
Juršėnaitė J, Girkontaitė I, Mauricas M, Eidukevičius R, Šiaurys A, Characiejus D.
Bioluminescence Imaging of Adoptively Transferred Lymphocytes During Allogeneic Tumor
Rejection. Anticancer Res. 2015 Dec; 35(12):6573-6.
Research Council of Lithuania, Lithuanian National Non-infectious diseases program.
Development of complex biomarkers for the evaluation of clinical significance of
prostate cancer (2012-2015). Project manager (research leader) – Prof. Juozas Lazutka,
Chief researcher – Prof. Arvydas Laurinavičius, Junior researchers: D. Petroška
The main goal of current project is to select new molecular biomarkers of prostate cancer
(gene mutations and epimutations, changes in gene and microRNA expression, etc.) that can
help more precisely predict the course of the disease and allow the use of the most
appropriate treatment, thereby reducing the number of unnecessary radical interventions and
improving patients' quality of life. Biomarkers indentified in our previous studies will be
further evaluated together with new biomarkers that would be selected on basis microarray
analysis. The sensitivity of the method will be increased by using sample micro-dissection
that will allow to separate tumor cells from normal stromal cells. Special attention will be
paid to the search and analysis of biomarkers urine sediments and blood plasma.
Identification and validation of such biomarkers will allow expanding range of non-invasive
disease prognosis methods.
Main publications:
1. Serenaite I, Daniunaite K, Jankevicius F, Laurinavicius A, Petroska D, Lazutka JR,
Jarmalaite S: Heterogeneity of DNA methylation in multifocal prostate cancer.
Virchows Archiv 2015; 466:53-59.
2. Demidenko R, Daniunaite K, Laurinavicius A, Lazutka JR, Jankevicius F, Jarmalaite
S: Gene expression profile of recurrent prostate cancer. BJU international 2015;
116:6-7.
Research Council of Lithuania. A comprehensive Biomarker intra-Tumour
heterogenecity evaluation by digital Immunohistocheminstry Image Analysis. Project is
funded under measure VP1-3.1-ŠMM-07-K-03-051 Support to Research Activities of
Scientists and Other Researchers (hereinafter referred to as ‘the Global Grant Measure’),
Priority 3 „Strengthening of Capacities of Researchers and other Scientists” of the
Operational Programme for Human Resources Development for 2007–2013, EU Social fund.
Research leader – Prof. Arvydas Laurinavičius
We aim to develop and test methodologies of intra-tumour heterogeneity assessment based on
various techniques of immunohistochemistry (IHC) digital image analysis and tissue
microarray (TMA) simulations. Principles of stereology and image texture analysis will be
applied to arrive to best strategies. Selected methodologies will be optimised for efficient and
robust application on whole slide images (WSI) and TMA. Validated tools will be applied on
well-characterised breast cancer patient cohorts in Caen, Nottingham, and Vilnius to derive
new generation of prognostic models, based on multivariate analyses of the IHC biomarker
expression taking into account spatial heterogeneity of the events. The methodologies
developed and prognostic models obtained will be cross-validated in this multi-centre study.
This work is innovative due to the integration of mathematical theories to the domain of
human pathology diagnosis in terms of methodology, quantitative analysis, and added value
of newly developed tumour heterogeneity metrics.
Main publications:
1. Laurinavicius A., Green A., Laurinaviciene A., Smailyte G., Ostapenko V.,
Meskauskas R, Ellis I. (2015). Ki67/SATB1 ratio is an independent prognostic factor
of overall survival in patients with early hormone receptor-positive invasive ductal
breast carcinoma. Oncotarget, 6(38), 41134-41145.
2. Plancoulaine B, Laurinaviciene A, Herlin P, Besusparis J, Meskauskas R,
Baltrusaityte I, Iqbal Y, Laurinavicius A: A methodology for comprehensive breast
cancer ki67 labeling index with intra-tumor heterogeneity appraisal based on hexagonal
tiling of digital image analysis data. Virchows Archiv 2015
3. Laurinavicius A, Plancoulaine B, Herlin P, Laurinaviciene A. Comprehensive
immunohistochemistry: digital, analytical and integrated. Pathobiology 2015, in print.
Research Council of Lithuania. “Pharmacist assistants (Pharmatechnicians) professional
development in the pharmaceutical specialisty”. No. VP1-2.2-ŠMM-04-V-06-017.
K.Ivanauskas, PhD. 2013.10.01-2015.06.30
International Research Projects
FP7-PEOPLE-2011-IRSES project “Sarcomere based Signals in Muscle Remodelling”,
acronym “SarcoSi” No.291834. – PEOPLE MARIE CURIE ACTIONS International Research
Staff Exchange. Prof. V. Grabauskienė, 2011-2015 m.
In SARCOSI, eight European laboratories will team up that have demonstrates scientific
excellence and complementary expertise in the field of sarcomeric signalling. The network
structure reflects also the geographic diversity of ERA with participating teams from France,
Germany, Italy, Lithuania, the Netherland, and the UK. The SARCOSI network included
both senior scientists that are scientific leaders within the ERA, as well as young team leaders
that are now setting up their own independent research groups. SARCOSI will support these
teams to become internationally competitive.
FP7-PEOPLE-2013-IAPP project Academia and Industry Collaboration for Digital
Pathology AIDPATH Marie Curie Industry-Academia Partnerships and Pathways (IAPP).
Prof. A.Laurinavičius. 2013-2017 m.
The scientific and technology program of the AIDPATH project will research and develop
fundamental technologies underpinning digital pathology. Thus, it will research and develop
technologies to optimize the imaging pipeline including standardizing and calibrating the
display of digital slide images. It will research and develop mathematical models and
computer software tools for processing, analysing and mining tissue-derived images of
cancers. Using a systems approach, biologically and clinically useful features and
information will be extracted for integrated disease modelling to provide deep comprehensive
holistic insights into the relations of various disease patterns and thus laying the foundation
for personalized treatment and medicine.
MAIN R&D&I (RESEARCH, DEVELOPMENT AND INOVATION) PARTNERS
Brigham and Women’s Hospital, Harvard Medical School, Boston, MA (USA)
Leuven University, Leuven (Belgium)
Ruprecht-Karls-universitat Heidelberg, EMBL (Germany)
University Hospital Gießen and Marburg (Germany)
Division of Clinical Pharmacology, Karolinska Institutet, Karolinska University
OTHER SCIENTIFIC ACTIVITIES
Prof. V. Grabauskienė –
National coordinator of Euro Heart Survey Programme (ESC),
http://www.escardio.org/initiatives/ehs/structure/ehscoord.htm;
fellow of the European Society of Cardiology (FESC),
http://www.escardio.org/bodies/membership;
member of the European Association of Echocardiography (EAE) of the ESC,
http://www.escardio.org/bodies/associations/EAE;
member of the Heart Failure Association (HFA) of the ESC,
http://www.escardio.org/bodies/associations/HFA;
member of the American Society of Echocardiography;
UEMS (European Union of Medical Specialist) Diploma of European Cardiologist
Nr.52546,http://www.uems.net;
member of the European Association for Predictive, Preventive and Personalized
Medicine (EPMA).
Prof. R. Dubakienė –
National representative for Lithuania in EU FP7 Health programme;
member of the Scientific Committee on Consumer Products of the European
Commission, www.eu.int.sccp;
expert member of Lithuanian Academy of Sciences;
Chairmain of Allergology Commission of Lithuanian Academy of Sciences;
expert of Lithuanian State Science and Studies Foundation;
editor-in-chief of the journal Alergologija ir klinikinė imunologija (Allergology and
Clinical Immunology, www.alergija.lt;
editorial board member of the journal Acta medica Lituanica;
editorial board member of the journal Revue of Allergology and Clinical
Immunology;
editorial board member of journal Medicinos teorija ir praktika (Theory and Practice
in Medicine;
editorial board member of the journal Immunopathologia;
vice-president of Lithuanian Society of Allergology and Clinical Immunology;
member of the Lithuanian Immunology Society;
member of the European Academy of Allergy and Clinical Immunology;
member of the European Respiratory Society (ERS);
member of UEMS board for Allergology and Clinical Immunology;
vice-chairman of the Council of the Institute of Immunology, Vilnius University;
Head of internet website Alergija, astma, imunologija (Allergy, Asthma,
Immunology), http://www.aai.lt.
Prof. A. Laurinavičius –
member of the International Society of Nephrology;
affiliate-member of the College of American Pathologists;
member, Clinical Nephrology Committee, Lithuanian Association of Nephrology,
Dialysis, and Transplantation;
member, European Society of Pathology;
vice-chairman of the board of the Lithuanian Society of Pathology;
editorial board member of the journal Medicina (Medicine);
editorial board member of the journal Diagnostic Pathology;
chairman, Management Board, Lithianian Association of Health Informatics and
Bioinformatics
Prof. D. Characiejus –
National Representative of the European Association for Predictive, Preventive and
Personalized Medicine (EPMA) in Lithuania;
editorial board member of The EPMA Journal;
member of the European Association for Cancer Research (EACR);
member of the European Society of Cancer Immunology and Immunotherapy
(ESCII);
member of the Council of the Lithuanian Society of Immunology.
Prof. V. Basys –
corresp. member, Lithuanian Academy of Sciences, Chairman of the Division of
Biological, Medical and Geosciences;
corresp. member, German Society of Pediatrics;
editor-in-chief of the journal Acta medica Lituanica;
editorial board member of the journal Lietuvos akušerija ir ginekologija (Lithuanian
Obstetrics & Gynaecology);
member of Lithuanian pediatric society.
Assoc. Prof. E. Žurauskas –
member of the Lithuanian Society of Pathology.
Assoc. Prof. D. Vaitkienė –
member of the Lithuanian Society of Pathology.
Assoc. Prof. Aida Laurinavičienė-
president of Lithuanian Association of Pathology Technologists
Assoc. Prof. Jūratė Kasnauskienė-
member of European Society of Human Genetics
member of Lithuanian Society of Human Genetics
U. Mickys –
board member of the Lithuanian Society of Pathology.
D. Petroška –
member of the Lithuanian Society of Pathology.
CLINIC OF PSYCHIATRY
Vasaros str. 5, LT-10309 Vilnius
Phone: +370 5 261 10 43, fax +370 5 231 37 47
E-mail: [email protected]
Head – Prof. Dr. Vita Danilevičiūtė
STAFF
Professors: Dr. V Danilevičiūtė, Dr. D. Pūras, Dr. A. Germanavičius (part-time).
Associate professors: Dr. A. Šiurkutė, Dr. S. Lesinskienė, Dr. E. Laurinaitis, Dr. A.
Navickas, Dr. B. Diomšina (part-time).
Research fellows: Dr. A. Dervinytė-Bongarzoni (part-time).
Lecturers: Dr. R. Aranauskas, Dr. A. Deksnytė, Dr. R. Viliūnienė (part-time).
Doctoral students: J. Radzevičienė, I. Veličkienė, E. Dlugauskas (part-time).
Assistants: R. Balčiūnas, I. Gaškaitė, I. Veličkienė, L. Bukelskis, E. Dlugauskas, D.
Natkevičienė, J. Ulevičienė, S. Ašvydienė, V. Stulpinas, E. Paužienė, E. Petkutė, J.
Daškevičienė, V. Mickutė, B. Kazilionytė, B. Didžiokaitė, L. Andrikienė, R. Židonienė, A.
Nemanienė, I. Treigienė (part-time).
RESEARCH INTERESTS
Evaluation of functioning and quality of life of patients with psychiatric disorders
Analysis of outcome variables of the treatment of psychotic, affective and neurotic disorders
Different approaches on psychosocial rehabilitation and assertive outreach for comprehensive
integrated community care for people with mental disorders in the community settings
Evaluation of services for people with mental illness and their carers
RESEARCH PROJECTS CARRIED OUT IN 2015
Projects Supported by University Budget
Prevalence, clinical pecurliarities of psychotic, affective and neurotic disorders;
relation of treatment and preventive methods with functioning of patients and quality
of their life. Prof. V. Danilevičiūtė. 2014-2018
During 2015 Clinic of Psychiatry concentrated on research on affective disorders.Our clinic
conticuere research on biological markers. Psychiatric Clinic contimed research on alkoholic
withdravel. We contimed research on Resilience Scale for Adults (RSA).
Main publications:
1. Hilbig J, Viliūnienė R, Friborg O, Pakalniškienė V, Danilevičiūtė V. Resilience in a
reborn nation: Validation of the Lithuanian Resilience Scale for Adults (RSA).
Comprehensive Psychiatry. 2015, Volume 60. Pages 126-133.
2. Diomšina B, Rasmussen P, Danilevičiūtė V. Clinical experience of long-term
treatment with aripiprazole (Abilify) in children and adolescents at the child and
adolescent psychiatric clinic 1 in Roskilde, Denmark. Acta Poloniae Pharmaceutica.
2015 Vil. 72, no 3 p. 597-606. ISSN 0001-6837.
3. Čiūras E, Dlugauskas E, Danilevičiūtė V. Interaction of antidepressants with
antiepileptic, antyhypertensive, non steroidal anti-inflammatory and anti-infective
drugs. Neurologijos seminarai 2015; 19(64): 77–83
Research on Suicide Behaviour and Implementation of the Suicide Prevention Methods
in Lithuania. Assoc. prof. A. Navickas. 2014–2018.
Research of suicidal behavior within Vilnius population; total Lithuanian population,
comparative analysis of suicides among EU countries. Participation in the Commiittee of
Suicide Prevention Plan in Vilnius municipality and signed Memorandum of the action
(2015-12-17). Organized: 3 international (6 presentation) and 4 national (6 presentation)
conferences and 2 seminars. 1 article was published and 1 international articicle and 5 other
scientific articles prepared for publishing.
Main publication:
Navickas A. Violence deaths. Lithuania in context of the European Union. Spectrum, 2015.
p. 26–29.
Complex care for children with mental and developmental disorders: implementation of
the model and evaluation of need for services. Prof D. Pūras. 2014 - 2018.
Management of mental, behavioral and developmental disorders in children and adolescents:
development of effective model of services and evaluation of need of services.
Research was carried out on the need of services for children with mental, behavioral and
developmental disorders. Preliminary results identified substantial gaps in the system of
services and the need for increasing quantity and quality of mental health services for
children and adolescents. Recommendations of this research are reflected in publications.
These recommendations were used by the Ministry of Health in formulation of guidelines for
further development of child and adolescent mental health serrvices in the Republic of
Lithuania.
Main partners - Lithuanian university of health sciences (LSMU)
Main publications:
1. duRivage N., Keyes K., Leray E., Pez O., Bitfoi A, Koç C., Goelitz D., Kuijpers R.,
Lesinskiene S., Mihova Z., Otten R., Fermanian C., Kovess-Masfety V. Parental Use of
Corporal Punishment in Europe: Intersection between Public Health and Policy. PLoS
ONE 10(2): e0118059.
2. Kovess-Masfety V., Pilowsky D.J, Goelitz D., Kuijpers R., Otten R., Moro M.F., Bitfoi
A., Koç C.,Lesinskiene S., Mihova Z., Hanson G., Fermanian C., Pez O., Carta M.G.
Suicidal ideation and mental health disorders in young schoolchildren across Europe.
Journal of Affective Disorders. Published online: February 20, 2015, Vol. 177, p. 28–35.
3. Olaya B., Moneta M.V., Pez O., Bitfoi A., Carta M. G., Eke C., Goelitz D., M Keyes K.,
Kuijpers R., Lesinskiene S., MihovaZ., Otten R., Fermanian C, Haro J.M., Kovess V.
Country-level and individual of overweight and obesity among primary schoolchildren:
a cross-sectional study in seven European countries. BMC Public Health ISSN: 1471-
2458 (Online). Published online: 8 May 2015.
National Research Projects
Research Council of Lithuania. Study on history of psychiatry in Soviet Lithuania 1944-
1990 (case of one psychiatric hospital) (No. 004/55/MTS-150000-317). Dr. T. Vaiseta
(Faculty of History) 2013-2015.
Dr. T. Vaiseta (led by scientific supervisor prof. dr. A. Germanavičius) has prepared and
submitted final report to Lithuanian Research Council, where he presents analysis of all
documents from national archives for documents related to Vilnius psychiatric hospital
(Vasaros str. 5, Vilnius) together with in-depth interviews with former psychiatric clinic
employees and ex-patients. This work gave impulse for public campaign on promotion of the
research on history of psychiatry (about 20 publications and public speaches), and
contributed to popularisation of science.
Research Council of Lithuania. Paradigm Change of Mental Health and Well-being in
Lithuania: Towards Empirically Valid Model (No. GER-15070) dr. Eglė Šumskienė. This
project is aimed to contribute to the paradigmatic change by scientific research and
evaluation of efficacy of pharmaceutical and pscyhotherapeutical treatment to psychological
and social functioning, and to estimate economic burden of treatment and mental diseases
that society must pay. Interdisciplinary group was formed for this research, including
representatives of sociology, psychology, psychiatry and economics. Within this project, it is
supposed to create valid model that enables evaluation of efficacy of different patterns of
treatment by various social, psychological and economical rates. It is planned to invoke the
results and experience of foreign colleagues researchers, estimate the deficits in the system of
mental health care, and to collect and analyze empirical data from providers of medical and
social services as well as from mental health care experts and service users. The combination
of quantitative and qualitative approach will be used in this longitudinal study.
Prof. A.Germanavicius gave oral presentation about research protocol of this project during
international conference of World Federation of Mental Health in Cairo, October 2015.
COST programme project: IS1302.
Prof. A. Germanavičius is deputy coordinator of National coordinator assoc. prof. Ilona
Česnienė (Vilnius University Faculty of Philosophy, Department of Psychology) at EU
COST project Action IS1302 "Towards an EU research framework on forensic
psychiatric care": http://www.cost.eu/domains_actions/isch/Actions/IS1302. In April and
October 2014 prof. A.Germanavicius participated in two international conferences of the
project in Cyprus and in Split (Croatia) respectively, where he worked within Working Group
WG1 activities (http://lfpc-cost.eu/). In accordance of this research protocol prof. A.
Germanavicius and forensic psychiatrist Aldona Šileikaitė have collected data on the
characteristics and determinants of inpatients of forensic psychiatric patients in Lithuania
(total sample of 335 inpatients of Rokiskis Forensic psychiatric hospital).
Main publications:
A. Rotomskis, R, Margevičiūtė, A. Germanavičius, G. Kaubrys, V. Budrys, A.
Bagdonas. Differential diagnosis of depression and Alzheimer's disease with
the Addenbrooke Cognitive Examination-Revised (ACE-R). BMC
Neurology. 2015, 15(1):57 doi:10.1186/s12883-015-0315-3.
1. Lanfredi M, Zoppei S, Ferrari C, Bonetto C, Van Bortel T, Thornicroft G, Knifton L,
Quinn N, Rossi G, Lasalvia A, ASPEN Study group. Self-stigma as a mediator
between social capital and empowerment among people with major depressive
disorder in Europe: The ASPEN study. European Psychiatry. 2015 Jan 31;30(1):58-
64.
2. Antonio Lasalvia, Tine Van Bortel, Chiara Bonetto, Geetha Jayaram, Jaap van
Weeghel, Silvia Zoppei, Lee Knifton, Neil Quinn,Kristian Wahlbeck, Doriana
Cristofalo, Mariangela Lanfredi, Norman Sartorius, Graham Thornicroft, the
ASPEN/INDIGO Study Group. Cross-national variations in reported discrimination
among people treated for major depression worldwide: the ASPEN/INDIGO
international study. The British Journal of Psychiatry. Dec 2015, 207(6)507-514;
DOI:10.1192/bjp.bp.114.156992
MAIN R&D&I (RESEARCH, DEVELOPMENT AND INOVATION) PARTNERS
Institute of Psychiatry Kings College, London (UK)
Viena S. Freud private university (Austria)
Department of Child and Adolescent Psychiatry of Heidelberg University (Germany)
Vilnius University, Faculty of Philosophy (Lithuania)
Lithuanian university of health sciences (LSMU)
OTHER SCIENTIFIC ACTIVITIES
Prof Dr. V. Danilevičiūtė –
member of board of Medical Faculty of Vilnius University;
editorial board member of the journal Medicinos teorija ir praktika (Theory and
Practice in Medicine) www.mtp.lt
Prof. A. Germanavičius –
editorial board member of the scientific journals Medicina (Biomedicine), Biologinė
psichiatrija ir psichofarmakologija (Biomedicine, Biological psychiatry and
psychopharmacology), Visuomenės sveikata (Public Health), Sveikatos mokslai
(Public Health)
peer reviewer of the scientific journal Health Education Journal (SAGE publishing
company)
Prof. D. Pūras –
member of Editorial board of the national journal „Visuomenės sveikata“ („Public
health“)http://www.hi.lt/content/D2_redkolegija.html
member of Editorial board of the national journal „Medicina“.
archives of Psychiatry and Psychotherapy, member of International Advisory Board
http://www.archivespp.pl/International-Advisory-Board.html
Assoc. Prof E. Laurinaitis –
editorial board member of the International Journal of Psychotherapy;
editorial board member of the journal Medicina (Medicine) http://medicina.kmu.lt;
editorial board member of the journal Pain Medicine (Skausmo medicina);
board member of European Association for Psychotherapy (EAP)
www.europsyche.org
president of European Association for Psychotherapy (EAP) www.europsyche.org;
Assoc. Prof. A. Šiurkutė –
member of Lithuanian Psychiatric Association (LPA);
Assoc. Prof. S. Lesinskienė –
consultant for child and adolescent psychiatry, Ministry of Health Care of the
Republic of Lithuania;
vice-president of Lithuanian Psychiatric Association;
editorial board member of the journal Pediatrija (Paediatrics)
www.medpraktika.lt/leidiniai/leidinys/2/Pediatrija
Assoc. Prof. A. Navickas –
president of the Lithuanian Association of Suicidology;
president of the Lithuanian Psychiatric Association;
member of International Association of Suicide Prevention;
member of the Commiittee of North Psychiatric Associations;
member of the Streering Commiittee of the European Psychiatric Association
editorial board member of the journal Biologinė psichiatrija ir psichofarmakologija
(Biological Psychiatry and Psychopharmacology) );
http://www.pri.kmu.lt/biological-psychiatry.ht;
chief editor board member of the journal Psichiatrijos žinios (News of Psychiatry);
member of section on classification, diagnostic assessment, nomenclature of World
Psychiatric Association.
DEPARTMENT OF RADIOLOGY, NUCLEAR MEDICINE AND MEDICAL
PHYSICS
Santariškių g. 2, LT-08661 Vilnius
Tel. +370 5 688 62 803
Tel./fax. +370 5 2365 177
E-mail: [email protected]
Head - Prof. Dr. Algirdas Edvardas Tamošiūnas
STAFF
Professors: Dr. A. E. Tamošiūnas, Dr. N. R. Valevičienė.
Associate professors: Dr. J. Dementavičienė, Dr. R. Briedienė, Dr. S. Letautienė, Dr. E.
Aleknavičius, Dr. R. Grigienė.
Lecturers: Dr. A. Samuilis, Dr. B. Gricienė, Dr. M. Matačiūnas.
Doctoral students : D. Palionis, A. Neverauskienė, K. Kristinaitytė.
Assist. Professors: A. Bajorinaitė.
RESEARCH INTERESTS
To create new functional and anatomical imaging techniques and evaluate effectiveness for
diagnostics of cardiovascular and oncological diseases
Estimation of iron overload in liver and heart on 3T MRI
Physical properties in vitro of metabolites using high resolution 9.4T NMR spectrometer
RESEARCH PROJECTS CARRIED OUT IN 2015
Projects Supported by University Budget
New functional and anatomical imaging techniques in cardiovascular and oncology
diagnostics. Prof. A.E. Tamošiūnas. 2014 - 2018.
Aim: to develop and evaluate new functional and anatomical imaging techniques in
cardiovascular and oncology cancer diagnostics.
National Research Projects
Research project Multi-parametric MRI for glial and metastatic brain tumors (2013-
2019). Value of multi-parametric MRI biomarkers for glial brain tumors morphology and
physiology. Assessment of glial brain tumors morphology and physiology by multi-
parametric MRI biomarkers. The purpose of this study is to compare MRI perfusion,
spectroscopy and tractography findings with tumour histological and molecular biology
examination. We want to find if there are any specific MRI markers which can help
determine histological tumor type and grade and predict its behaviour. Trial aim is to evaluate
accuracy and applicability of multiparametric MRI biomarkers for diagnosis of brain tumours
histological type, differential grade and neovascularisation assessment. Participants include
National Cancer Institute, Neuroangiosurgery Center of Vilnius University, UZ Brussels.
Research Council of Lithuania. Research project „Healthy Aging“. Optimisation of
Computed Tomography Radiation Doses in Lithuania.
The objective of this research – reduce the adverse health effects and risk of cancer
development by using computer tomography and nuclear medicine assays, and to develop
and improve the tools and instruments for the diagnosis and medical decisions of the lifespan
shortening and life quality affecting diseases by utilizing medical imaging technologies. As
the survey result - will be provided recommendations to health care institutions, created the
optimized protocols and developed the tool (software with the database) for the collecting,
filing and analyzing patients’ doses obtained by utilizing ionization radiation in medical
assays.
International Research Projects
Euro CMR registry project. The European Cardiovascular Magnetic Resonance
(EuroCMR) Registry is an initiative of the ESC Working Group "Cardiovascular Magnetic
Resonance". Enrolment of patients on a European level started in March 2009, resulting in
the largest database on the clinical use, the impact on patient management, image quality and
safety of cardiovascular MR (CMR) available so far. Including the German pilot phase
(2007-2009) 31.500 patients from 58 centers in 15 countries all over Europe have been
collected. In addition to the questionnaire of the pilot phase, dedicated scientific issues will
be addressed by individual additional protocols.
Enhancing safety and quality of computer tomography for pediatric patients. Submitted
to IAEA as regional project for 2015-18 period. CT is the largest contributor to medical
radiation exposure among the Lithuania population. Significant increase in the use of CT has
led to higher patient doses, which has fuelled concern about the long-term consequences of
these exposures, especially for children, who have a several times higher risk of developing
the radiation-related cancer in comparison with adults, even if the received radiation dose is
the same. Obective of the project is to reduce the dose level while still answering the clinical
questions creating optimized CT scanning protocols instead of standard adapted for children.
Research data was presented in 12th International Conference “Medical Physics in the Baltic
States 2015”.
Main publications:
1. Brazaitis A, Tamošiūnas A, Tutkuvienė J. Patellofemoral joint biomechanics in the
females with anterior knee pain applying full weight bearing kinematic MRI. Acta
medica Lituanica 2015; 22 (1).
2. Neverauskienė A, Gricienė B, Petkelytė M, Vištartaitė B, Mockienė E, Jonuškaitė D,
Praninskienė R, Tamošiūnas A E. Vaikų galvos kompiuterinės tomografijos tyrimų,
atliktų dėl neurologinių simptomų, diagnostinė svarba ir apšvita. Medicinos teorija ir
praktika. 2015; 21( 4.1): 477-482. ISSN 1392-1312.
3. Palionis D., Berukstis A., Misonis N., Ryliskyte L., Celutkiene J., Zakarkaite D.,
Cerlinskaite K., Valeviciene N., Tamosiunas A., Laucevicius A. Could careful patient
selection for renal denervation warrant a positive effect on arterial stiffness and left
ventricular mass reduction?. Accepted for publishing. Acta Cardiologica, 2015-07-02
MAIN R&D&I (RESEARCH, DEVELOPMENT AND INOVATION) PARTNERS
SATT LUTECH & Université Pierre et Marie Curie (Paris, France)
OTHER SCIENTIFIC ACTIVITIES
Assoc. prof. Dr. Juratė Dementavičienė –
member of editorial board ,, Theory and Practice in Medicine“
Dr. Ruta Briedienė –
managing editor ,,Acta Medica Lituanica”
Dr. Rūta Grigienė –
member of the editorial board of the journal “World Journal of Surgical Oncology”
REHABILITATION, PHYSICAL AND SPORTS MEDICINE DEPARTMENT
Santariškių str. 2, LT-08661 Vilnius, Lithuania
Tel.: +370 52365173
E-mail [email protected]
Head – Prof. dr. (HP) Alvydas. Juocevičius
STAFF
Professors: Dr. A. Juocevičius, Dr. V. Alekna, Dr. J. Raistenskis, Dr. M. Tamulaitienė.
Associate professors: Dr. R. Dadelienė.
Lecturers: Dr. L. Būtėnaitė, Dr. J. Indriūnienė, Dr. I. E. Jamontaitė, Dr. D. Janonienė, Dr. S.
Lenickienė, Dr. I. Muntianaitė, Dr. A. Mastavičiūtė, Dr. I. Tvarijonienė, Dr. A. Valiulis.
Assistants: A. Adomavičienė, L. Aučynienė, J. Bernatavičius, F. Blužaitė, A. Budėjienė, A.
Cirtautas, J. Kesienė, S. Kilkutė, J. Kupčiūnas, A. Miezienė, dr. L. Mikulėnaitė, T. Palšytė,
D. Saprunova, J. Stasiukynienė, S. Strička, A. Šidlauskienė, L. Varnienė, R.Venskaitis.
Doctoral students: A. Adomavičienė, G. Narmontaitė, I. Raudonytė, I. Slivovskaja.
RESEARCH INTERESTS
Etiopathogenesis, diagnostics, treatment, rehabilitation and prevention of disease:
fundamental and clinical research
RESEARCH PROJECTS CARRIED OUT IN 2015
Projects Supported by University Budget
Prognostication of Comprehensive Rehabilitation Effectiveness in Patients with
Movement Disturbances. Prof. A. Juocevičius. 2014 - 2018.
The aim of this research is to search comprehensive rehabilitation effectiveness
prognostication parameters; to prepare methodology of comprehensive rehabilitation
prognosis in patients with movement disturbances; to perform comparable examination of
comprehensive rehabilitation prognostication, using functional status evaluation.
In 2015, the staff of the Department continued performance of comparable examination and
methodology development of comprehensive rehabilitation effectiveness prognostication. On
the base of these data, 11 articles were published in scientific journals, and research workers
took part at international and in Lithuanian scientific meetings: 7 poster presentations and 9
oral reports.
Main publications:
1. Indriulionis T, Raistenskis J, Saniukas K et. al. Efficiency of Orthopaedic Brace with
Laser on Knee Joint Function, Pain and Swelling. Baltic Journal of Sport & Health
Sciences. 2015; 3(98); p.13-21.
2. Muntianaitė I, Balčius T,. Jamontaitė I E. Relationship between training frequency
and functional movements of basketball players. The risk of sport injuries. Sport
science. 2015; 1(79): 56-62.
3. Adomavičienė A, Juocevičius A. Biopsychosocial factors predicted the functioning in
daily life, social activities and occupations among persons with SCI. Journal of
rehabilitation medicine, 2015, Vol. 47, No. 8, p. 782.
MAIN R&D&I (RESEARCH, DEVELOPMENT AND INOVATION) PARTNERS
National Rehabilitation Centre Vaivari (Latvia)
Haapsalu Neurological Rehabilitation Centre (Estonia)
Karolinska Institute (Sweden)
Notwill Rehabilitation Centre (Switzerland)
Hannover medical school (Germany)
OTHER SCIENTIFIC ACTIVITIES
Prof. Habil Dr. A. Juocevičius –
president of the European Union of Medical Specialists (UEMS - PRM) Physical and
Rehabilitation Medicine Board
member of the European Physical and Rehabilitation Medicine Scientific Board;
vice-president of the Baltic and North Seas forum on Physical and Rehabilitation
Medicine;
president of the Baltic Spinal Cord Injury Scientific Society;
head of Vilnius Region Physical Medicine and Rehabilitation Physicians’ Association
editorial board member of the journals “Gerontologija” (Gerontology), “Internistas”
(Internist), “Neurologijos seminarai” (Neurology seminars)
permanent secretary and member of Health Ministry Commissions on Sports
Medicine and Rehabilitation Issues
chairman of the Rehabilitation Master studies programme committee
chairman of working groups of the rehabilitation field studies programmes, and self-
study programmes.
Prof. Habil. Dr. V. Alekna –
chief editor of the journal “Gerontologija” (Gerontology)
committee member of the Rehabilitation Master’s studies programme
vice-President of Lithuanian Society of Geriatricians
president of Lithuanian Osteoporosis Foundation
Prof. Dr. M. Tamulaitienė –
editorial board member of the journal “Gerontologija” (Gerontology)
committee member of the Rehabilitation Master’s studies programme
member of the self-assessment work group of Rehabilitation study programmes
Lecturer Dr. D. Janonienė –
chairman of the Occupational Therapy Undergraduate studies programme committee
member of the Rehabilitation Master’s Studies programme committee;
member of the self-assessment work group of Rehabilitation field studies
programmes.
Lecturer Dr. I. E. Jamontaitė –
chairman of the Physiotherapy Undergraduate studies programme committee
member of the work group of Rehabilitation field studies programmes description
under Education and Science Ministry
board member of Lithuanian Physiotherapy association
Lecturer Dr. S. Lenickienė –
member of the Rehabilitation Master’s Studies programme committee;
delegate of the European Union of Medical Specialists (UEMS - PRM) Physical and
Rehabilitation Medicine Section
Assistant A. Cirtautas –
member of the Occupational Therapy Undergraduate studies programme committee
board member of ENOTHE
board member of Lithuanian Physiotherapy association
honory member of Lithuanian Ooccupational therapy Asociation
Assistant, doctorant A. Adomavičienė –
member of the working group of Rehabilitation studies programmes
DEPARTMENT OF RHEUMATOLOGY, ORTHOPEDIC TRAUMA AND
RECONSTRUCTIVE SURGERY
Santariškių g. 2, LT-08661 Vilnius-21
Tel. 236 5303, fax. +370 5 2365302
E-mail: [email protected]
Head - Prof. Habil. Dr. Algirdas Venalis
STAFF
Professors: Prof. Habil. Dr. I. Butrimienė, Prof. Habil. Dr. N. Porvaneckas, Prof. Habil. Dr.
K. Vitkus
Associate professors: Dr. M. Kocius, Dr. V. Uvarovas, Dr. R. Rugienė, Dr. S. Stropuvienė,
Dr. L. Zabulienė
Lecturers: Dr. I. Šatkauskas, Dr. S. Ryliškis, Dr. N. Jakutis
Research fellows: Dr. Š. Mažeika, Dr. R. Rugienė, Dr. D. Miltinienė
Doctoral students: T. Sveikata, D. Karpec, R. Šakalytė, E.Puncevičienė, E. Tertelienė
RESEARCH INTERESTS
Light emitting diodes effect in systemic sclerosis patients
Peculiarities of applying biological therapy to rheumatic patients in Lithuania
Evolution of immunogenicity in rheumatic patients with anti-TNF treatment
Outcomes of early undifferentiated arthritis
Evaluation of femoral head blood flow and ischemic factors after femoral neck fracture
Influens of the psychosocial factors on the early knee joint replacement outcomes
Influence of the perioperative optimization on the hip replacement outcomes
Anatomical and clinical study: Medialisation of the stitches in modified Ma Griffith MI
repair for Aciles tendon rupture
Functional outcomes after pelvic ring ant acetabulum fracture treatment
RESEARCH PROJECTS CARRIED OUT IN 2015
Projects Supported by University Budget
Phototherapy application for the systemic sclerosis patients in clinical practice. Prof. A.
Venalis. 2014–2018.
The main objective of the project is evaluation of narrow band light beam of ultraviolet A1
(UVA1) and infrared (IFR) light effect on skin elasticity, microcirculation and general
condition in patients with systemic sclerosis.
Associations between genetic, epigenetic factors and rheumatoid arthritis
ethiopathogenesis and clinical course. I. Butrimienė. Since 2015, Ongoing.
Aim of study: Scientific literature analysis about vitamin D receptor gene polymorphisms and
higher risk of autoimmune rheumatic disease, vitamin D correlation with disease activity and
severity, analysis of influence on immunomodulatory effect. Data collection of epigenetics
(DNA methylation, microRNR, histon modification, ect.) that potentially mediates genetic
risk for autoimune rheumatic diseases. Analysis of association between risk factors and
epigenetics in pathogenesis of disease. Special attention will be kept on vitamin D
concentration and oral health as external risk factors in higher susceptibility for rheumatic
diseases and influence in ethiopathogenesis by causing changes in gene function.
Sociodemographic, clinical, and laboratory parameters significance for the early
undifferentiated arthritis outcomes. Prof. A. Venalis. 2014 – 2018.
The main objective of this project is to evaluate the significance of certain clinical, laboratory
(including genetic), and sociodemographic parameters, alone or in combination, for the
outcomes of early undifferentiated arthritis. The aim of the this study is to find a method
that will diagnose chronic inflammatory joint disease as soon as possible, before irreversible
joint damage is present and to determine when to start treatment with antirheumatic disease
modifying drugs. Study design and methodology protocol is developed according to the
literature analysis. This study is already approved by Lithuanian Bioethics Committee.
Rheumatic diseases and functional-structural alterations of cardiovascular system over
time. A. Venalis. Since 2014, Ongoing.
The aim of this study is to reveal the progression of structural and functional alterations of
arteries in rheumatic diseases over time. Five years after initial examination 210 patients with
rheumatic diseases (80 patients with rheumatoid arthritis, 80 with systemic lupus
erythematosus and 50 with systemic sclerosis) will be invited to participate in this study.
Classic cardiovascular disease risk factors will be evaluated as well as occurrence of new
cardiovascular events over a period of five years; endothelial dysfunction and arterial
stiffness measurements will be performed, additional assessment of patients intima-media
thickness and arterial stiffness of the carotid artery, and the longitudinal movements of the
common carotid artery assessments will be conducted. The patient’s risk of having
cardiovascular event over the next 10 years will be calculated. Comparing clinical,
laboratory, vascular endothelial dysfunction and arterial stiffness changes in rheumatic
patients is expected to identify the factors leading to the development of early atherosclerosis.
Extensive clinical examination of the patients micro and macrovascular endothelial cell
dysfunction, their correlation with immunological blood tests, and analysing changes over
time could lead to new insights on these rare and little studied diseases.
Development of Lithuanian Database of Biologic Therapy for the Treatment of
Rheumatic Diseases. I. Butrimienė. Since 2007, Ongoing.
With the help of IT specialists a software program was created for developing a medical
database for patients treated with biological therapy in Lithuania. The Bioethics Committee
of Lithuania on November 14, 2007 issued a permit to conduct this biomedical research
project Creation of a Lithuanian database of Rheumatic illness. Since 01 December 2007
data of patients with rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis and
juvenile idiopathic arthritis treated with biologics were entered in the Lithuanian database of
biologic therapy in rheumatic diseases (BIOLIT) from 5 Centres of Rheumatology across
Lithuania.
By December 2015 information was collected and recorded from 472 patients with
rheumatoid arthritis, ankylosing spondilitis, psoriatic arthritis and juvenile idiopathic arthritis
treated with biologics in the Centre of Rheumatology at Vilnius University Hospital
Santariškių Klinikos (total 3170 questionnaires). We continue analyzing patients’ data
concerning treatment efficacy, drug immunogenicity and adverse events profile, with special
attention to latent tuberculosis and infectious complications.
Main publications:
1. Arstikyte I, Butrimiene I, Petrulioniene A, Venalis A. A rare kind of lymphoma in a
patient treated with two different biological agents. Arch Rheumatol. 2015; 30(1):75-
78. Online first: doi: 10.5606/ArchRheumatol.2015.4383.
2. Arštikytė I, Butrimienė I, Venalis A. Results of observational study on biologic
therapy for the treatment of autoimmune arthritis (data from the Lithuanian database
of biologic therapy of rheumatic diseases). Medicinos teorija ir praktika. 2015;
21(3.2):390-405. doi: 10.15591/mtp.2015.063.
Peculiarities of Applying Biological Therapy to Rheumatic Patients in Lithuania. I.
Butrimienė. Since 2007, Ongoing
Data obtained from the database of biological therapy for the treatment of rheumatic diseases
in Lithuania is used for analysis of peculiarities of applying biological therapy to rheumatic
patients in Lithuania. The data collected from paper questionnaires and in digital format are
used only by researchers. This research is conducted according to the Law on Patient
Confidentiality, i.e. only scientific research findings were published.
Evolution of Immunogenicity in Rheumatic Patients treated with Anti-TNF. I.
Butrimienė. 2012 – 2015.
The project is devoted to the investigation of secondary failure of treatment of rheumatic
patients under anti-TNF treatment. Patients treated with anti-TNF blockers are investigated
for the concentration of medication and antibodies to the drug. Correlation of these
parameters with clinical effectiveness, adverse events and other possible events were
determined.
Main publication:
Arstikyte I, Kapleryte G, Butrimiene I. Venalis A. Influence of immunogenicity on the
efficacy of long-term treatment with TNFα blockers in rheumatoid arthritis and
spondyloarthritis patients. BioMed Research International. 2015; Article ID 604872, 10
pages. Online first: http://dx.doi.org/10.1155/2015/604872.
Orthopedic trauma
Clinical, psychosomatic and radiologic peri- and postoperative evaluation of axial
skeleton and joint degenerative diseases. Prof. N.Porvaneckas. 2014-2018.
Title: Comparison of three tourniquet application methods in primary total knee arthroplasty
surgery
The protocol was approved by the Regional Ethical Committee and registered at
Clinicaltrials.gov (identifier: NCT01355900). Double blinded randomized study was
performed from January 2010 to February 2014. The scientific thesis was defended on
September 2015.
Main publications:
1. Andrijauskas A, Svensen CH, Ivaskevicius J, Porvaneckas N, Kvedaras G, Marmaite
U. Goal Directed Fluid Therapy Revised: Indirect Monitoring of Interstitial Fluid
Accumulation During Mini Fluid Challenges with Crystalloids. The Open Conference
Proceedings Journal, 2012, 3, 42-51.
2. Kvederas G, Porvaneckas N, Andrijauskas A, Svensen CH, Ivaskevicius J, Mazunaitis
J, Marmaite U, Andrijauskas P. A randomized double-blind clinical trial of tourniquet
application strategies for total knee arthroplasty. Knee Surg Sports Traumatol
Arthrosc, 2013, 21: 2790-9.
A prospective randomized study of minimally invasive treatment of acute Achilles tendon
rupture
The protocol was approved by the Regional Ethical Committee. Prospective randomized
study January 2015 - December 2019.
Main publication:
Comparative anatomical study of standard percutaneous and modified medialized
percutaneous Bunnell type repair for artificial Achilles tendon rupture: positive effect of
medialisation of the stitches with lower risk of sural nerve injury. Folia Morphologica. A.
Makulavicius, X. Martin, G. Mazarevicius, M. Klinga, V. Uvarovas, N. Porvaneckas, M.
Monzo Planella, T. Mazurek. DOI:10.5603/FM.a2015.0067. Submited: 2015-04-16,
Accepted:2015-06-23, Published online: 2015-09-03
A prospective study study of functional outcomes after pelvic ring ant acetabulum fracture
treatment
Main publications:
1. V. Uvarovas, I. Šatkauskas, G. Petryla, N. Porvaneckas, M.Kocius. Primary total hip
arthroplasty after acetabular bended plates. Acta Orthopaedica Belgica. 2015
(accepted)
2. A. Bruzauskaite, D. Bironaite, E.Bagdonas, V. A. Skeberdis, J. Denkovskij, T.
Tamulevicius, V. Uvarovas, E. Bernotiene. Relevance of HCN2-expressing human
mesenchymal stem cells for the generation of biological pacemaker. Journal of Stem
cell Research and therapy. 2015 (accepted)
National Research Projects
Research Council of Lithuania. Influence of the perioperative optimization on the results
of the hip replacement outcomes. Prof.C.Svensen, Dr.A.Andrijauskas, Prof. N.Porvaneckas.
2013-2015.
We continued the prospective randomized clinical trial within a research project The
influence of perioperative optimization on the results of primary endoprosthesis of the hip
joint funded by the European Social Fund under the Global Grant measure (VP1-3.1-ŠMM-
07-K-03-019; the EU Structural Funds).
Main publications:
1. Markevičius V, Andrijauskas A, Navikas D, Svensen C, Porvaneckas N, Andriukaitis
D, Kvederas G, Cincikas D, Andrijauskas P. Statistically Biased Calibration Method
for the Real-time Adjustment of Noninvasive Haemoglobin Measurements in
Semiautomated Infusion System. Electronics and Electrical Engineering, 2013,
19(7): 1392-1215.
2. Markevicius V, Andrijauskas A, Navikas D, Dubauskiene N, Porvaneckas N,
Stankevicius E, Uvarovas V, Gelzinis G, Cepenas M, Andriukaitis D, Malekian R. In
Silico Testing of the Semi-Closed Loop Infusion System with a New Simulator.
Electronics and Electrical Engineering, 2014; 20(9):19-24. DOI:
http://dx.doi.org/10.5755/j01.eee.20.9.8520
3. Andrijauskas A, Markevicius V, Navikas D, Porvaneckas N, Andriukaitis D,
Stankevicius E, Uvarovas V, Sipylaite J, Kvederas G, Gelzinis G. In Vivo Testing of
the Semi-Closed Loop Infusion System: the Preliminary Observations. Elektronika ir
Elektrotechnika. 2015; 21(1):28-32.
International Research Projects
The EULAR Scleroderma Trials and Research group (EUSTAR) initiated multicentral Online
study Minimum Essential Data Set. Cordinator: Walker, Ulrich A. University Basel
Minimal essential data set (MEDS) Online is an international registry established by the
European League against Rheumatism scleroderma trial and research (EUSTAR), which
collects data from over 8000 patients from 92 centres worldwide, including 21 European
centres (R. Rugiene in Vilnius University Hospital Santariskiu Klinikos) and 9 centres
outside Europe. Center contribution: clinical patient data input online, updated on an annual
basis.
Main publication:
Ingegnoli F, Boracchi P, Gualtierotti R, Smith V, Cutolo M, Foeldvari I; EUSTAR co-
authors. A comparison between nailfold capillaroscopy patterns in adulthood in juvenile and
adult-onset systemic sclerosis: A EUSTAR exploratory study. Microvasc Res. 2015
Nov;102:19-24. doi: 10.1016/j.mvr.2015.07.007.
Early rheumatoid arthritis outcomes
The aim of the study was to compare mortality in early rheumatoid arthritis cohorts
comparing patients from Lithuania and Finland (Jyvaskyla Central Hospital Jyvaskyla,
Finland and Vilnius University Hospital Santariskiu Klinikos, Vilnius, Lithuania). A 13-year
follow-up study.
Main publications:
1. Dadonienė J, Stropuvienė S, Stukas R, Venalis A, Sokka-Isler T. Predictors of
mortality in patients with rheumatoid arthritis in Lithuania: Data from a cohort study
over 10 years. Medicina (Kaunas). 2015; 51(1):25-31
2. Stropuviene S. Reumatoidinio artrito diagnostika. Lietuvos gydytojo žurnalas. 2015
Nr 3(76) 10-13.
EMerging EUlar NETwork (EMEUNET)
Diana Karpec is a working group member and country liaison of EMEUNET. EMEUNET is
a EULAR working group of young clinicians and researchers in rheumatology. The
objectives of EMEUNET are to promote education, perform research, widen collaborations
and integrate with EULAR activities. Diana Karpec as country liaison is responsible for
disseminating and promoting provided information amongst young clinicians and scientists
within the country. As a working group member she belongs to the website subgroup
(www.eular.emeunet. org).
During the last year D. Karpec took a part as a principal investigator in an international
survey concerning differences and similarities in rheumatology training programs across
European countries. D. Karpec collected data from Lithuania rheumatology trainees. The
results are analyzed and described in this publication.
Main publication:
Sivera F, Ramiro S, Cikes N, Dougados M, Gossec L, Kvien TK, Lundberg IE, Mandl P,
Moorthy A, Panchal S, da Silva JA, Bijlsma JW; Working Group on Training in
Rheumatology across Europe. Differences and similarities in rheumatology specialty training
programs across European countries. Ann Rheum Dis. 2015 Jun; 74(6):1183-7.
MAIN R&D&I (RESEARCH, DEVELOPMENT AND INOVATION) PARTNERS
Department of Clinical Science and Education, Karolinska Institutet Södersjukhuset. Section
of Anaesthesiology and Intensive CareSE 118 83 Stockholm, Sweden
VU Faculty of Physics, Department of Quantum Electronics (Lithuania)
State Research Institute Centre for Innovative Medicine (Lithuania)
The EULAR Scleroderma Trials and Research group (Italy)
The European League Against Rheumatism (Switzerland)
Södersjukhuset Section of Anaesthesiology and Intensive CareSE 118 83 Stockholm, Sweden
OTHER SCIENTIFIC ACTIVITIES
Prof. N. Porvaneckas –
editorial board member of the journal Medicina.
editorial board member of the journal Medicinos teorija ir praktika
Doc.M.Kocius –
editorial board member of the journal Medicinos teorija ir praktika
Prof. A. Venalis –
Board member of European League against Rheumatism;
member of executive committee for clinical trials in European League against
Rheumatism;
member of the Lithuanian Rheumatology Association;
editorial board member of the journals Reumatologijos seminarai (Seminars in
Rheumatology);
co-president of the organizing committee of annual conference Vilnius Rheumatology
Seminars;
editorial board member of the journal Rheumatology (Poland).
Prof. I. Butrimienė –
board member of Opinion Leaders for Biological Therapy, Europe;
member of executive committee for clinical trials in European League against
Rheumatism;
president of Lithuanian Arthritis Foundation;
member of the Lithuanian Rheumatology Association;
editorial board member of the journals Reumatologijos seminarai (Seminars in
Rheumatology) and Skausmo medicina ( Pain Medicine) ;
co-president of the organizing committee of annual conference Vilnius Rheumatology
Seminars
Dr. S. Stropuvienė -
EULAR Standing Committee on Education and Training (ESCET), Delegate member;
editorial board member of the journals Reumatologijos seminarai (Seminars in
Rheumatology);
acting secretary of the Lithuanian Rheumatology Association;
Dr. R. Rugienė –
editorial board member of the journals Reumatologijos seminarai (Seminars in
Rheumatology);
member of the organizing committee of annual conference Vilnius Rheumatology
Seminars;
member of The EULAR Scleroderma Trials and Research group (EUSTAR);
member of the Lithuanian Rheumatology Association.
DEPARTMENT OF NURSING AND FUNDAMENTALS OF INTERNAL MEDICINE
Antakalnio str. 57, LT-10207 Vilnius
Phone / fax: +370 5 271 1176, + 370 5 234 4261
E-mail: [email protected]
Head – Prof. Habil. Dr. Danutė Kalibatienė
STAFF
Professors: Habil. Dr. D. Kalibatienė, Habil. Dr. V. Gaigalaitė, Habil. Dr. R. Ėmužytė (part-
time), Dr. (HP) V. Alekna (part-time), Dr. (HP) S. Cicėnas (part-time).
Docents: Dr. V. Ožeraitienė, Dr. A. Gradauskas, Dr. Ž.Visockienė (part-time).
Senior research fellows:
Lecturers: Dr. R. Staigis, Dr. S. Varvuolytė, Dr. A. Mikaliūkštienė, Dr. Olga Nečajauskaitė
(part-time), Dr. R. Šturienė (part-time), Dr. R. Stundžienė (part-time), Dr. Z. Gierasimovič
(part-time), V. Karpavičienė, M. Buitkus (part-time), E. Gruodytė (part-time).
Assistants: I. Fomčenko (part-time), D. Jakučionis (part-time), V. Kielaite (part-time), I.
Dailidkienė (part-time), J.Gimžauskienė (part-time).
Senior specialists: Z. Svirid.
Specialists: E. Kuzienė, M. Voroneckij.
Doctoral students: V. Sinkevičienė, V. Karpavičienė, A. Jomantienė.
RESEARCH INTERESTS
Investigation Of Etiopathogenetic Risk Factors Of Internal Diseases
Development Of Optimal Methods Of Diagnosis In Ischemic Cerebral And
Cardiovascular Diseases, Internal Diseases (Gastrointestinal, Diabetes, Bone),
Pediatric Allergology, Allergology And Clinical Immunology, Abdominal surgery
Quality Of Life Of Patients With Internal Diseases
Investigation Of New Factors Influencing Lung Cancer Treatment Efficiency
Nursing Needs Of Patients With Internal, Surgical, Mental, Children’s Diseases
RESEARCH PROJECTS CARRIED OUT IN 2015
Projects Supported by University Budget
Research of the Etiopathogenesis of Internal Diseases, Detection of Optimal Diagnostic
and Treatment Methods. Prof. D. Kalibatienė. 2014–2018
There were carried out the several researches for detection of optimal diagnostic methods.
The aim of first research was to investigate the quality of life (QoL), sense of coherence in
patients with atrial fibrillationThe investigation concluded that lower education, income and
family status (single), duration of atrial fibrillation and heart failure NYHA functional class
III and IV were associated with lower QoL. Patients with AF may attribute to the medium
level of sense of coherence.
The aim of next research was to evaluate the prevalence of vertebral artery (VA) hypoplasia
in young adults and to find associations between the VA diameter and blood flow volume and
demographic as well as anthropometric indicators. The investigation concluded that VA
hypoplasia is a frequent anomaly of VA. However, high degree VA hypoplasia influencing
blood flow volume is rare. The prevalence of VA hypoplasia in general population depends
on demographic and anthropometric indicators. Further the large study is continuing to assess
the impact of VA hypoplasia on the posterior circulation stroke or transient ischemic attack.
102 patients with acute pancreatitis were included in the multicenter prospective study. The
first results of this study concluded that the BISAP score (“Bedside Index of Severity in
Acute Pancreatitis”) between the others (HAPS, CTSI, MCTSI) is sufficiently precise,
universal for early prediction of severe acute pancreatitis, necrosis, can predict the needs of
further interventions and outcomes. The laboratory marker hematocrit is a sufficiently early
and precise marker for differentiating severe pancreatitis from mild acute and moderate
severity disease course.
Main publications:
1. Karpavičienė V, Kalibatienė D. Sense of Coherence in Patients with Atrial
Fibrillation. Theory and Practice in Medicine. 2015, Vol. 21 (Nr. 4.3), p. 841- 847.
2. Gaigalaitė V, Ožeraitienė V, Vilimas A, Polevoda V. Vertebral Artery Hypoplasia in
Young Adults. Theory and Practice in Medicine. 2015, Vol. 21 (Nr. 4.3), p. 829 –
833.
3. Karpavičius A, Dambrauskas Ž, Samuilis A, Gradauskas A, Žvinienė K, Brimas G,
Činčikas J, Mečkovski A, Šileikis A, Strupas K. The value of clinical and radiological
scores for acute pancreatitis severity and complications assessment. The results of the
multicenter prospective study. Theory and Practice in Medicine. 2015, Vol. 21 (Nr.
4.3), p.814 – 822.
The Evaluation of Nursing Needs and Quality of Life and Perfection of Health Care and
Education of Patients. Prof. D. Kalibatienė. 2014–2018
The aim of scientific study in nursing was to research types of verbal and physical violence
experienced by nurses working with the patients suffering from psychomotor agitation and to
identify how various factors have impact on the psychological resilience and emotional state
of the nurses. An overview of the strategic EU documents has showed that in the last decade
patient safety has received much attention. In spite of the efforts, in all the EU countries the
process of patient safety policy formation encounters problems. The number of undesirable
events in EU country health care systems has been growing. 8-12% of the patients treated in
EU country hospitals and receiving heath care services have experienced undesirable events
that lead to financial loses of the states. A lack of information on the patient safety that would
be continuously disseminated to health care specialists, the patients and the public at large,
reduces the possibilities to improve patient safety and the quality of health care services, as
well as increases the confrontation between health care specialists and the patients and
establishes an environment of mutual mistrust. In order to improve patient safety, enough
attention should be given to team work, while teamwork in contemporary world is one of the
vital factors in determining the success of an organization.
Main publications:
1. Kymelytė-Slapšinskaitė N, Mikaliūkštienė A, D. Kalibatienė D. Assessment of the
Hospital Based End-of-Life Care on Account of the Nursing Expertise. Theory and
Practice in Medicine. 2015, Vol. 21 (Nr. 4.3), p. 752 – 759.
2. Ožeraitienė V., Gabrilavičiūtė L., Gaigalaitė V. Investigation of Psychological
Resilience and Emotional Status, Verbal and Physical Violence against the Nurses
Caring Psychomotor Agitated Patients. Theory and Practice in Medicine. 2015, Vol.
21 (Nr. 4.3), p. 834 – 840.
3. Jerdiakova N, Mikaliūkštienė A, Kalibatienė D. Insurance of the Patient Safety in
Health Care Facilities. Theory and Practice in Medicine. 2015, Vol. 21 (Nr. 4.3), p.
739 – 745.
MAIN R&D&I (RESEARCH, DEVELOPMENT AND INOVATION) PARTNERS
National Centre of Pathology http://www.vpc.lt/
The Institute of Oncology Vilnius University, Laboratory of Biomedical Physics;
http://www.vuoi.lt/index.php?541183821#
The Faculty of Physics, Laser Research Center
STŘEDNÍ ZDRAVOTNICKÁ ŠKOLA, Chech Republic
OTHER SCIENTIFIC ACTIVITIES
Prof. D. Kalibatienė -
internist-consultant and head of the Department of Internal Diseases at Vilnius
Clinical Hospital;
member of the Interuniversity Committee for Nursing studies and research;
member of the Council of the Faculty of Medicine of Vilnius University;
editorial board member of the journal Medicinos teorija ir praktika (Theory and
Practice in Medicine);
editorial board member of the journal Slauga. Mokslas ir praktika
http://www.sdtsc.lt/index.php?id=285.
member of the Lithuanian Society of Gastroenterology
http://www.gastroenterologija.lt/
member of the Lithuanian Society of Internists
member of the Lithuanian Society of Palliative Medicine
http://www.paliatyvipagalba.lt/
board member of the Society of Lithuanian Nurses with university education
http://www.lusd.lt/
head of the self-assessment work group of Nursing Studies programmes.
head of the Nursing Bachelor’s and Master’s degree final thesis Defending
Committee.
Prof. V. Gaigalaitė -
member of Lithuanian Society of Neurology
member of Lithuanian Society of Stroke
editorial board member of the journal Slauga. Mokslas ir praktika.
http://www.sdtsc.lt/index.php?id=285
Prof. R. Ėmužytė -
president of Lithuanian Society of Allergology and Clinical Immunology
chair of the Organizing Committee of the National Conference of Lithuanian Society
of Allergology and Clinical Immunology
national representative of EAACI Education and Training Committee – Paediatric
Allergology (ETC–PA)
national representative of European ARIA (Allergic Rhinitis and its Impact on
Asthma) Committee
national representative of WHO Collaborating Centre
editorial board member of the journal Vaikų pulmonologija ir alergologija (Paediatric
Pulmonology and Allergology)
editorial board member of the journal Alergologija ir klinikinė imunologija
(Allergology and Clinical Immunology);
editorial board member of the journal Alergia astma immunologia (Allergy Asthma
Immunology) (Poland);
editorial board member of the journal Pediatrija (Paediatrics)
Prof. S. Cicėnas -
board member of the ESTS (European Society of Thoracic Surgeons)
member of the IASLC (International Association for study of lung cancer)
board member of the Lung Cancer Study Group EORTC (European organization for
research and treatment of cancer)
board member of the Lithuanian Society of Cardiothoracic Surgeons.
editorial board member and of the journal (Lithuanian Surgery)
editorial board member of the journal BSM (Biological Science Monitor) expert of
malignant pleural mesothelioma issues
member of Lithuanian Society of Pulmonology and Allergy
Doc. dr. V. Ožeraitienė -
internist at Vilnius Clinical Hospital in Department of Abdominal Surgery
member of the Lithuanian Society of Gastroenterology
http://www.gastroenterologija.lt/
member of the Lithuanian Society of General Practitioners;
http://gydytojas.blogspot.com/
member of Nursing Bachelor’s and Master’s degree final thesis Defending
Committee.
the responsible Secretary of work Committee for the defense of the Masters work
editorial board member of the journal Slauga. Mokslas ir praktika
http://www.sdtsc.lt/index.php?id=285
Doc. dr. A. Gradauskas –
head of the Clinic of Surgery at Vilnius city Clinical Hospital;
vice-president of Vilnius Association of Surgeons;
board member of the Lithuanian Association of Minimally Invasive Surgery
http://www.mich.lt/.
Dr. A. Mikaliūkštienė –
member of the Lithuanian University Education Nursing Society Board
http://www.lusd.lt/
member of the Lithuanian Society of Palliative Medicine
http://www.paliatyvipagalba.lt/
member of the self-assement work group of Nursing Studies programmes
member of Nursing Bachelor’s’s degree final thesis Defending Committee.
editorial board member of the journal “Sveikatos mokslai”(Helth sciences)
editorial board member of the journal “Slauga: mokslas ir praktika”.
Dr. R. Stundžienė –
chair of the Lithuanian University Education Nursing Society Board
http://www.lusd.lt/
member of Lithuanian Nursing Specialists Organization http://www.lsso.lt/
member of Nursing Bachelor’s’s degree final thesis Defending Committee.
Dr. Z. Gierasimovič –
member of the Lithuanian University Education Nursing Society Board
http://www.lusd.lt/
editorial board member of the journal “Slauga: mokslas ir praktika”.
member of Nursing Bachelor’s’s degree final thesis Defending Committee.
CLINIC OF CARDIOVASCULAR DISEASES
2 Santariškių str., LT-08661 Vilnius
Tel. 236 5307, fax 236 52 11
E-mail [email protected]
Head – Academician Prof. Habil. Dr. Aleksandras Laucevičius
STAFF
Professors: Dr. (HP) A. Aidietis, Dr. A. Kibarskis, Dr. (HP) G. Marinskis, Dr. (HP) Ž.
Petrulionienė, Dr. (HP) K. Ručinskas, Dr. P. Šerpytis, Dr. V. Tarutis.
Associate professors: Dr. S. Aidietienė, Dr. J. Čelutkienė (part-time), Dr. R. Karalius, Dr. B.
Petrauskienė, Dr. A. Rudys, Dr. R. Steponėnienė, Dr. G. L. Vilkevičius.
Lecturers: Dr. J. Barysienė (part-time), Dr. G. Davidavičius (part-time), Dr. J. Misiūra, Dr.
N. Misonis (part-time), Dr. M. Sučila, Dr. R. Vaitkevičius (part-time).
Research fellows: Dr. J. Badarienė (part-time), G. Burneikaitė (part-time), Dr. I. Butkuvienė,
Dr. A. Čypienė (part-time), Dr. R. Čypienė, K. Drėgūnas, Dr. S. Glaveckaitė (part-time), Dr.
V. Grabauskienė, Dr. (HP) A. Grebelis, Dr. L. Gumbienė, Dr. L. Jurgauskienė, Dr. G.
Kalinauskas, Dr. Ž. Katliorienė (part-time), Dr. E. Rinkūnienė, Dr. L. Ryliškytė, Dr. P.
Semėnienė, A. Simanavičienė, Dr. R. Sipavičius (part-time), Dr. S. Sudikas (part-time), Dr.
B. Vaišnytė (part-time), Dr. A. Valaika, Dr. D. Zakarkaitė (part-time), A. Zorinas (part-time),
Dr. G. Zuozienė (part-time).
Doctoral students: A. Aliachmed, A. Baranauskas, A. Berukštis, L. Bezuška, M. Budra, G.
Burneikaitė, A. Drąsutienė, E. Gaižauskas, V. Janušauskas, J. Jarašūnas, V. Juknevičius, S.
Kutkienė, E. Lycholip, A. Lipnevičius, R. Navickas, G. Račkauskas, V. Rudienė, A.
Skrebūnas, S. Solovjova, E. Stanevičiūtė, A. Zorinas.
RESEARCH INTERESTS
Investigation of arterial wall functional and structural disorders in atherosclerosis and
metabolic syndrome
Primary and secondary prevention of cardiovascular diseases: development of high risk
strategy in prevention of cardiovascular diseases
Fundamental and clinical research in cardiac arrhythmias: improvement of methods of
complex treatment of atrial and ventricular tachyarrhythmia
Surgical treatment of atrial fibrillation (MAZE procedures, minimal invasive thoracoscopic
surgery)
Resynchronization therapy in heart failure
Complex multi imaging assessment of left and right ventricular function in coronary artery
disease, hypertension and heart failure
Myocardial regeneration therapy by cardiac pulse wave therapy in coronary heart disease
Congenital heart disease cardiac surgery in infants
New possibilities of hybrid (interventional and surgical) and minimally invasive technologies
in cardiovascular medicine
Investigation of vascular dysplasias
Investigation of endothelial function in the patients with acute peripheral arterial disease
Introduction of intraoperative angiography and analysis of the results
RESEARCH PROJECTS CARRIED OUT IN 2015
Projects Supported by University Budget
Prevention of atherosclerosis, diagnosis and treatment of induced diseases. Prof. A.
Laucevičius 2014 - 2018.
During the 2015, a large 3 year research project was completed and results accepted by the
Research Council of Lithuania. During the project, over 800 intermediate cardiovascular risk
patients were analyzed for personalized CVD risk assessment and diastolic dysfunction
diagnostic biomarkers. A separate group of patients with resistive hypertension and their
response to renal denervation procedure was investigated, for predictive biomarkers for the
long-term effect and quality of the procedure.
Main publications:
1. Laurent S., Parati G., Chazova I., Sirenko Y., Erglise A., Laucevicius A., Farsang C.
Randomized evaluation of a novel, fixed-dose combination of perindopril
3.5mg/amlodipine 2.5mg as a first-step treatment in hypertension. Journal of
Hypertension 2015;33(3):653-662.
2. Rinkūnienė E., Laucevičius A., Petrulionienė Ž., Dženkevičiūtė V., Kutkienė S., Skujaitė
A., Kasiulevičius V. The prevalence of dislipidemia and its relation to other risk factors: a
nationwide survey of Lithuania. Clinical Lipidology 2015; 10(3):219–225.
3. Laucevičius A., Ryliškytė L., Balsytė J., Badarienė J., Puronaitė R., Navickas R.,
Solovjova S. Association of cardio-ankle vascular index with cardiovascular risk factors
and cardiovascular events in metabolic syndrome patients. Medicina-Lithuania 2015;
51(3):152-158.
New technologies for management of structural heart diseases and arrhythmias. Prof.
dr. (HP) A.Aidietis, prof. dr. (HP) K.Ručinskas, 2014 - 2018.
A minimally invasive transapical mitral valve repair program using Neochord DS-1000
system (11 patients). Transapical closure approach for the treatment of a prosthetic valve
paravalvular leak (4 patients). A percutaneous (femoral and trans apical approach) aortic
valve disease treatment (11 patients). Results have been presented in cardiothoracic meetings
(WSCTS 2015, Edinburg, UK; Mitral conclave 2015, New-York, USA; Heart valve society
meeting 2015, Nica, France).
Main publications:
1. Colli A., Manzan E., Rucinskas K., Janusauskas V., Zucchetta F., Zakarkaite D., Aidietis
A., Gerosa G. Acute safety and efficacy of the NeoChord procedure. Interactive
Cardiovascular and Thoracic Surgery 2015, 20(5):575-581.
2. Merk D.R., Aidietis A., Seeburger J. Off-pump transapical neo-chordae implantation.
Annals of Cardiothoracic Surgery 2015:4(3):293-294.
3. Rackauskas G., Saygili E., Rana O.R., Saygili E., Gemein C., Laucevicius A., Aidietis A.,
Marinskis G., Šerpytis P., Plisienė J., Pauža D.H., Schauerte P. Sub-threshold high
frequency electrical field stimulation induces VEGF expression in cardiomyocytes. Cell
Transplantation 2015;24(8):1653-1659.
Improvement and evaluation of congenital heart disease surgery. Prof. dr. V. Tarutis.
2014 - 2018.
There was further evaluation of the Functional Single Ventricle type repair surgery in our
centre 45 pts. were evaluated and the results of the younger group where comparable with the
patiens in the elder group more then 3 years old, with the tendency towards less amount of
pleural effusions in the younger patients group. The impact of Coronary Arteries Anomalies
into the results of the surgical correction of the Transposition of the Great Arteries was
estimated. There was no significant influence of variable coronary arteries anatomy patterns
into the postoperative mortality, except aortic cross clamping and perfusion times were
prolonged. A very rare congenital anomaly of the right atrial aneurysm was presented as a
case report with the excellent long term results of the surgical treatment.
Main publications:
1. Bezuska L., Lebetkevicius V., Lankutis K., Sudikiene R., Sirvydis V.J., Tarutis V. Fontan
Completion for younger than 3 years of age: outcome in patients with Functional Single
Ventricle. Pediatric Cardiology 2015; 36:1680-1684.
2. Jonavičius K., Lipnevicius A., Sudikiene R., Zurauskas E., Lebetkevicius V., Tarutis V.
Surgical repair of a giant congenital right atrial aneurysm: a case report. Journal of
Cardiothoracic Surgery 2015, 10:72.
3. Jonavičius K., Lipnevicius A., Katliorienė Ž., Lankutis K., Sudikienė R., Liekienė D.
Lebetkevicius V., Tarutis V. Vainikinių arterijų anatomijos įtaka stambiųjų kraujagyslių
transpozicijos chirurginiam gydymui Vilniaus universiteto ligoninės Santariškių klinikų
Širdies chirurgijos centre. Lietuvos bendrosios praktikos gydytojo priedas 2015, 19(8):20-
24.
National Research Projects
Research Council of Lithuania. Evaluation of the novel arterial markers considering the
predicted impairment of left ventricular diastolic function and the monitoring of its
progression. (VP1-3.1-ŠMM-07-K-03-041). Prof. A.Laucevičius (2013-2015).
A prospective group of 1100 patients with metabolic syndrome was included in the study, in
770 arterial markers were repeated at the end of follow-up of 3.5 years. The relationship of
extensive list of laboratory parameters and markers of arterial stiffness to the cardiovascular
outcomes and development of diastolic dysfunction was determined. The pulse wave velocity
was found to be the most powerful predictor of diastolic dysfunction and cardiovascular
outcomes in this patient population, what is reported in two publications.
Main publications:
1. Badarienė J., Čelutkienė J., Petrikonytė D., Balsytė J., Rinkūnienė E., Ryliškytė L.,
Dženkevičiūtė V., Čypienė A., Kizlaitis R., Puronaitė R., Laucevičius A. Diagnostic
value of electrocardiogram stress testing in patients with metabolic syndrome. Seminars
in Cardiovascular Medicine 2015;21:9–15.
2. Solovjova S., Ryliškytė L., Čelutkienė J., Badarienė J., Navickas R., Puronaitė R.,
Bieliauskaitė G., Skiauterytė E., Lisaitė G., Laucevičius A. Aortic stiffness is an
independent determinant of left ventricular diastolic dysfunction in metabolic syndrome
patients. Blood Pressure 2016;25(1):11-20.
MAIN R&D&I (RESEARCH, DEVELOPMENT AND INNOVATION) PARTNERS
Ghent University Hospital, Ghent, Belgium
Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical
Centre, Maastricht, the Netherlands
Southampton University Hospital, Wessex Cardiothoracic Centre, England
The Department of Cardiothoracic Surgery, University of Pittsburgh Physicians, Pittsburgh
OTHER SCIENTIFIC ACTIVITIES
Prof. A. Laucevičius –
member of American College of Cardiology (FACC);
fellow of the European Society of Cardiology (FESC);
member and fellow of North American Society of Pacing and Electrophysiology
(NASPE);
member of the Lithuanian Academy of Sciences (full member), http://lma.lt/en/about-
lac/the-presidium/list-of-members
member of the Council of the Faculty of Medicine of Vilnius University;
member of the Lithuanian Society of Cardiology;
editorial board member of the journal Medicina (Lithuania)
http://medicina.kmu.lt/editor-l.htm;
editorial board member of the journal Seminars in Cardiovascular Medicine,
http://www.seminarsincardiology.com/archive-issues.php ;
editorial board member of the journal Internistas (Internist);
editorial board member of the journal Mediterranean Journal of Pacing and
Electrophysiology (MESPE),
editorial board member of the journal Journal of Human Hypertension,
editorial board member of the journal Blood pressure, Europace (ESC),
editorial board member of the journal Cardiology Management,
editorial board member of the journal Cardiology Journal (Folia Cardiologica)
Prof. dr (HP) A. Aidietis –
board member of Lithuanian Heart Association;
Chairman of Heart Rhythm workgroup at Lithuanian Society of Cardiology;
member of Lithuanian Society of Thoracic and Cardiac Surgeons;
member of Scandinavian Association for Thoracic Surgery
editorial board member of the journal Seminars in Cardiovascular Medicine,
http://www.seminarsincardiology.com/archive-issues.php
Prof. dr. A. Kibarskis –
vice-president of Baltic Association of Interventional Cardiology;
editorial board member of the journal Gydymo menas (Art of Treatment);
editorial board member of the journal Medicinos teorija ir praktika (Theory and
Practice in Medicine), www.mtp.lt.
Prof. dr. (HP) G. Marinskis –
editor-in-Chief of the journal Seminars in Cardiovascular Medicine,
http://www.seminarsincardiology.com/archive-issues.php
President of Lithuanian Society of Cardiology
President of organizing committees of the „4th Baltic Heart Failure meeting” and 12th
International conference „Arrhythmia Lithuania 2014”
member of the Credentials committee;
board member of Lithuanian Heart Association;
European Society of Cardiology - Member of Fellowship Committee;
European Heart Rhythm Association - Member of Nomination Committee.
Prof. dr. (HP) Ž. Petrulionienė
editorial board member of the journal Seminars in Cardiovascular Medicine,
http://www.seminarsincardiology.com/archive-issues.php
editor of chapter Cardiologic Seminars of the journal Internistas (Internist);
President of Lithuanian Heart Association.
member of the European Society of Cardiology.
Chairman of Prevention and Rehabilitation workgroup at Lithuanian Society of
Cardiology;
Prof. dr. P. Šerpytis –
Chairman of Intensive Cardiac Care workgroup at Lithuanian Society of Cardiology;
member of the European Society of Cardiology.
Prof. dr. V. Grabauskienė –
National coordinator of Euro Heart Survey Programme (ESC),
http://www.escardio.org/initiatives/ehs/structure/ehscoord.htm;
fellow of the European Society of Cardiology (FESC),
http://www.escardio.org/bodies/membership;
member of the European Association of Echocardiography (EAE) of the ESC,
http://www.escardio.org/bodies/associations/EAE;
member of the Heart Failure Association (HFA) of the ESC,
http://www.escardio.org/bodies/associations/HFA;
member of the American Society of Echocardiography;
UEMS (European Union of Medical Specialist) Diploma of European Cardiologist
Nr.52546,http://www.uems.net;
member of the European Association for Predictive, Preventive and Personalized
Medicine (EPMA).
member of Lithuanian Society of Thoracic and Cardiac Surgeons.
Prof. dr. V. Tarutis –
member of Scandinavian Association for Thoracic Surgery;
member of Lithuanian Society of Thoracic and Cardiac Surgeons;
Associate professor dr. A. Aidietienė
board member of Lithuanian Heart Association;
member of Lithuanian Society of Cardiology;
member of the European Society of Cardiology.
Associate professor dr. (HP) A. Grebelis –
member of the European Society for Cardiovascular Surgery;
member of Lithuanian Society of Thoracic and Cardiac Surgeons;
member of the Society of Lithuanian Surgeons;
member of Scandinavian Association for Thoracic Surgery.
Associate professor dr. R. Karalius –
member of the European Society for Cardiovascular Surgery;
member of Lithuanian Society of Thoracic and Cardiac Surgeons.
member of the Society of Lithuanian Surgeons;
member of the Society of Cardiology of Lithuania;
member of the European Society of Cardiology;
member of Scandinavian Association for Thoracic Surgery.
Associate professor dr. G. Vilkevičius –
editorial board member of the journal “Przegland Flebologiczny“;
editorial board member of the journal “Flebologija“;
member of European Federation of Societies for Ultrasound in Medicine and Biology;
member of Lithuanian society for vascular surgery;
vice-president of Lithuanian society for phlebology;
member of Lithuanian Association of Ultrasound Diagnostics
Associate professor dr. J. Čelutkienė –
Chairman of Heart Failure workgroup at Lithuanian Society of Cardiology;
Dr. L. Gumbienė –
member of the Lithuanian Society of Pediatric Cardiology.
Dr. Ž. Katliorienė -
member of the Lithuanian Society of Pediatric Cardiology.
Dr. D. Liekienė –
member of the Lithuanian Society of Pediatric Cardiology.
Dr. R. Malickaitė –
board member of Lithuanian Society for Immunology;
board member of Lithuanian Society for Alergology and Clinical Immunology.
Dr. R. Sipavičius –
editorial board member of the journal Lietuvos chirurgija (Lithuanian Surgery),
http://www.chirurgija.lt/;
member of Lithuanian Society of Thoracic and Cardiac Surgeons.
Dr. J. Misiūra –
member of Lithuanian Society of Thoracic and Cardiac Surgeons;
member of the ESC Working Group of Heart Failure.
Dr. S.Sudikas –
member of Lithuanian Society of Vascular Surgery
member of Society of Vilnius surgeons
member of Lithuanian Society of Surgeons.
Dr. M. Sučila –
member of Lithuanian Society of Vascular Surgery
member of Society of Vilnius surgeons
member of Lithuanian Society of Surgeons.
Dr. B. Vaišnytė -
member of Lithuanian Society of Vascular Surgery
member of Society of Vilnius surgeons
member of Lithuanian Society of Surgeons.
Prof. Dr. (HP) A. Aidietis, Prof. Dr. V. Grabauskienė, Prof. Dr. A. Kibarskis, Prof. Dr
(HP) G. Marinskis, Associate professor Dr. B. Petrauskienė, Associate professor Dr. A.
Rudys, Associate professor Dr. R. Steponėnienė, Associate professor Dr. J. Čelutkienė,
Dr. A. Čypienė, Dr. R. Čypienė, Dr. D. Liekienė, Dr. J. Misiūra, Dr. P. Semėnienė, Prof.
Dr. P. Šerpytis -
members of European Society of Cardiology;
members of Lithuanian Heart Association;
members of Lithuanian Society of Cardiology.
Dr. R. Čypienė, Dr. G. Kalinauskas, Dr. V. Lebetkevičius, Dr. D. Liekienė, Dr. R.
Malickaitė, Dr. G. Norkūnas, Prof. Dr. (HP) K. Ručinskas, Dr. P. Semėnienė, Dr. A.
Valaika, Dr. I. Butkuvienė, A. Zorinas
members of Lithuanian Society of Thoracic and Cardiac Surgeons.
Dr. G. Norkūnas, Prof. Dr. (HP) K. Ručinskas -
members of Scandinavian Society of Thoracic Surgery.
CLINIC OF CHILDREN’S DISEASES
4 Santariškių, LT- 08406 Vilnius
Tel. 249 2414
Fax 272 0368
E-mail: [email protected]
Head – Prof. Habil. Dr. Vytautas Usonis
STAFF
Professor emeritus: Habil. Dr. A. Raugalė.
Professors: Habil. Dr. V. Usonis, Habil. Dr. A. Valiulis, Dr. N. Drazdienė, Dr. A.
Jankauskienė Dr. L. Ragelienė, Dr. O. Rudzevičienė
Associate professors: Dr. R. Čerkauskienė, Dr. S. Dumčius, Dr. J. Grikinienė, Dr. O.
Kinčinienė, Dr. V. Panavienė, Dr. V. Urbonas, Dr. R. Vankevičienė, Dr. V. Žilinskaitė.
Lecturers: Dr.S.Burokienė, Dr.I.Ivaškevičienė, Dr. R. Kemežys, Dr. G. Kleinotienė,
Dr.A.Liubšys, Dr. S. Petraitienė.
Assistents: V.Radžiūnienė
Senior research fellows: Dr. R. Ėmužytė, Dr. R. Firantienė.
Junior research fellows: Dr. B. Skerlienė, K.Ažukaitis, N. Giedraitė, I.Kairienė.
Doctoral students: T.Alasevičius, V. Bilius, S. Burokienė, N.Buterlevičiūtė, R. Ivaškevičius,
A.Jagelavičienė, A.Mulevičienė, R. Selvestravičius
RESEARCH INTERESTS
Health care of mother and child: physiological and social aspects and research of natural
development of the child
Studies of functional development of organs and systems of newborns and children
Studies of neonatal pathology and perinatal mortality in Lithuania
Studies of chronic inflammation in paediatric pulmonology (asthma, cystic fibrosis, COPD)
and elaboration of markers of early diagnostics of chronic diseases in children
Development of the methods of diagnostics, treatment and prophylaxis of acute and chronic
infectious, immune, allergic, metabolic, haematologic and oncohaematologic diseases
Studies of immunoprophylaxis and vaccination
Diagnostics and treatment of inherited metabolic diseases
Diagnostics, treatment and prophylaxis of children’s abuse and trauma
Diagnostics and surgical treatment of inborn anomalies
RESEARCH PROJECTS CARRIED OUT IN 2015
Projects Supported by University Budget
Regulation of Causes and Outcomes of Children's Diseases, Traumas and Inborn
Anomalies. Prof. V. Usonis. 2014 – 2018.
Nationwide renal biopsy data in Lithuania 1994–2012 was evaluated: the most common
entity was IgA nephropathy, followed by focal segmental glomerulosclerosis and
membranoproliferative glomerulonephritis; prominent decrease in incidence of
membranoproliferative glomerulonephritis and increase in crescentic glomerulonephritis
were noted over the study period. Pre-hospital paediatric healthcare services in emergency
departments: perspectives for optimisation were analysed. The study on timing of surgery for
cryptorchidism and fertility prediction based on the evaluation of spermatogenesis in
testicular biopsies suggested early orchopexy up to 1 year of age; in particular cases
pharmacological treatment with LH-RH analogues should be considered.
Interaction between genotype and immune factors in the pathogenesis of bronchial asthma
was analysed. The significance of fetal inflammatory response syndrome in early and later
adaptation of premature infants was studied. Panton-valentine leukocidin presence and not
methicillin-resistance is associated with severe invasive community-acquired staphylococcus
aureus infections in Children – it was shown as a result of an European Multi-Centre (PISA)
study.
Main publications:
1. Nationwide renal biopsy data in Lithuania 1994–2012 / E Brazdziute, M Miglinas, E
Gruodyte, J Priluckiene, A Tamosaitis, I A Bumblyte, V Kuzminskis, S Burbaickaja,
M Sakalauskiene, A.jankauskiene, R Cerkauskiene, B Pundziene, A Laurinavicius.
International Urology and Nephrology Dordrecht, Springer Vol. 47, no 4. p. 655-662.
ISSN 0301-1623.
2. Long-term follow-up of children with typical hemolytic uremic syndrome / B
Pundzienė, D Dobilienė, R Čerkauskienė, R Mitkienė, A Medzevičienė, E
Darškuvienė, A.jankauskiene. Medicina Amsterdam, Elsevier BV Vol. 51, iss. 3. p.
146-151. ISSN 1010-660X.
3. Nauja membranoproliferacinio glomerulonefrito klasifikacija: vaikų atvejai Lietuvoje
= New classification of membranoproliferative glomerulonephritis: paediatric cases in
Lithuania /N Giedraitė, J Besusparis, R Čerkauskienė, J Masalskienė, A.Jankauskienė.
Medicinos teorija ir praktika = Theory and Practice in medicine. 2015, t. 21, Nr. 3.1.
p. 316–320. ISSN 1392-1312.
OTHER SCIENTIFIC ACTIVITIES
Prof. emeritus habil.dr. A. Raugalė –
member of the Council of Vilnius Paediatric Society;
editor-in-chief of the journal Pediatrija (Paediatrics);
editorial board member of the journal Vaikų pulmonologija ir alergologija (Paediatric
Pulmonology and Allergology).
Prof. habil dr. V. Usonis –
teaching staff member of Paediatric Infectious Diseases Programmee of the
Department for continuing education of University of Oxford;
member of Central European Vaccination Advisory Group (CEVAG);
expert on vaccine-related issues at the European Disease Control Centre (ECDC);
vice-President and a board member of the Lithuanian Paediatric Society;
Chairman of the Lithuanian Paediatric Society Committee on Immunisation;
Board member on the National Board of Immunisation of Lithuania;
Chairman of Lithuanian Committee for Poliomyelitis Eradication Certification;
editorial board member of the Paediatric Infectious Disease Journal;
editorial board member of the journal Medicinos teorija ir praktika (Theory and
Practice in Medicine);
editorial board member of the journal Vaikų pulmonologija ir alergologija (Paediatric
Pulmonology and Allergology);
editorial board member of the journal Pediatrija (Paediatrics);
Chairman of Baltic Immunoprophylaxis Association (BALTIPA);
President of the International Conference Vilnius Course 2015
Prof. habil.dr. A. Valiulis –
President of the Lithuanian Paediatric Society (till November 2015);
Lithuanian Delegate in European Academy of Paediatrics (CESP);
Lithuanian Delegate in European Paediatric Association (UNEPSA);
President of the Lithuanian Paediatric Respiratory Society;
Vice-chairman of the Committee of Mother and Child of the Lithuanian Academy of
Sciences;
Editor-in-chief Index Copernicus journal (Impact factor 3.94) Vaikų pulmonologija ir
alergologija ( Paediatric Pulmonology and Allergology);
editorial board member of ISI journal (Impact factor 2.77) Paediatric Respiratory
Reviews;
national Coordinator of WHO project Global Alliance Against Chronic Respiratory
Diseases (GARD);
member of Strategic Paediatric Alliance for the Future Health of Children in Europe
(EAP-EPA-ECPCP);
President of the international conference "XX Vilnius International Paediatric
Pulmonology and Alergology Conference-School" 2015 04 20
Prof. N. Drazdienė –
editor-in-chief of the journal Lietuvos akušerija ir ginekologija (Lithuanian Obstetrics
and Gynaecology);
editorial board member of the journal Pediatrija (Paediatrics);
editorial board member of the journal Sveikata (Health);
editorial board member of the journal Akušerijos ir ginekologijos ultragarsinė
diagnostika (Ultrasound Diagnostics in Obstetrics and Gynaecology);
vicepresident of Lithuanian Neonatology Association;
member of the European Association on Perinatal Medicine;
president of Lithuanian section of Deutsch-Baltische Arztegesellschaft www.deutsch-
baltische-aerzte.de;
Prof.A. Jankauskienė –
president of Lithuanian Society for Paediatric Nephrology;
member of Lithuanian Nephrology, Dialysis and Transplantation Association;
member of International Paediatric Nephrology Association;
member of the European Society for Paediatric Nephrology;
member of International Paediatric Hypertension Association;
member of Lithuanian Paediatric Society;
editorial board member of the journal Medicinos teorija ir praktika (Theory and
Practice in Medicine);
Prof. L. Ragelienė –
member of the Lithuanian Society of Haematology;
member of the International Society of Haematology;
member of Society of Paediatric Oncology of Northern Countries;
member of Baltic Haemophilia Council;
member of World Federation of Haemophilia;
editorial board member of the journal Pediatrija (Paediatrics);
Prof. O. Rudzevičienė –
board and council member of Lithuanian Society of Allergology and Clinical
Immunology;
member of the European Academy of Paediatrics (CESP Delegates: Lithuania);
member of the Council of Lithuanian Paediatric Society;
editorial board member of the journal Pediatrija (Paediatrics);
deputy chairman of the peer review board of the journal Vaikų pulmonologija ir
alergologija (Paediatric Pulmonology and Allergology);
Assoc.prof. R. Čerkauskienė –
Vice-president of Lithuanian Society for Paediatric Nephrology;
member of Lithuanian Nephrology, Dialysis and Transplantation Association;
member of International Pediatric Nephrology Association;
member of Vilnius Paediatric Society;
editorial board member of the journal Medicinos teorija ir praktika (Theory and
Practice in Medicine).
Assoc. Prof. S. Dumčius –
member of the European Respiratory Society;
member of the European Cystic Fibrosis Association;
editorial board member of the journal Vaikų pulmonologija ir alergologija (Paediatric
Pulmonology and Allergology).
Dr. R. Ėmužytė –
editorial board member of the journal Vaikų pulmonologija ir alergologija (Paediatric
Pulmonology and Allergology);
editorial board member of the journal Alergologija ir klinikinė imunologija
(Allergology and Clinical Immunology);
editorial board member of the journal Medinfo;
international editorial board member of the journal Alergia astma immunologia
(Allergy Asthma Immunology) (Poland);
editorial board member of the journal Pediatrija (Paediatrics);
pastmember at large of Executive Committee of European Academy of Allergology
and Clinical Immunology (EAACI);
Lithuanian representative in European Training Committee of Paediatric Allergology;
national representative of European ARIA (Allergic Rhinitis and its Impact on
Asthma) Committee;
member of the Lithuanian Society of Allergology and Clinical Immunology
Dr. R. Firantienė –
member of the Lithuanian Society of Allergology and Clinical Immunology.
Assoc.prof. J. Grikinienė –
member of Lithuanian Association of Neurology;
member of Lithuanian Paediatric Neurology Society;
member of Lithuanian Society of Epileptology;
member of Lithuanian Paediatric Society.
Dr. R. Kemežys –
editorial board member of the journal Baltic Endocrinology,
member of the Council of Lithuanian Endocrine Society;
member of Lithuanian Paediatric Society;
member of Paediatric Endocrinology Association;
member of International Growth Hormone Research Society (GRS);
member of the European Federation of Endocrine Societies (EFES);
member of International Society for Pediatric and Adolescent Diabetes (ISPAD).
Assoc.prof. O. Kinčinienė –
president of the Lithuanian Paediatric Cardiology Society;
deputy editor of the journal Pediatrija (Paediatrics);
Assoc. Prof. V. Panavienė –
member of Paediatric Rheumatology European Society (PRES);
national representative in the PRES Training and Education committee;
member of Paediatric Rheumatology International Trial Organisation (PRINTO);
member of the Council of Lithuanian Rheumatology Association;
editorial board member of the journal Pediatrija (Paediatrics);
editorial board member of the journal Reumatologija (Rheumatology).
Dr. B. Skerlienė –
member of Society for the Study of Inborn Errors of Metabolism (SSIEM);
member of the Baltic Metabolic Group;
member of Lithuanian Society of Paediatric Gastroenterology and Nutrition;
member of Lithuanian Rheumatology Association;
editorial board member of the journal Pediatrija (Paediatrics);
international editorial board member of the journal Medycyna
Środowiskowa(Environmental Medicine) (Poland).
Assoc.prof. V. Urbonas –
President of the Lithuanian Paediatric Society (since November 2015);
member and representative of the Baltic countries of the European Society for
Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN);
President of the Lithuanian Society for Paediatric Gastroenterology and Nutrition;
consultant as paediatric gastroenterologist at the Ministry of Health of the Republic of
Lithuania;
member of the peer review board of the ESPGHAN conferences (European Society of
Paediatric Gastroenterology and Nutrition);
member of the peer review board of the UEGW conferences (United European
Gastroenterology Week);
editorial board member of the journal Gastroenterologija (Gastroenterology);
Assoc.prof. R. Vankevičienė –
editorial board member of the journal Pediatrija (Paediatrics);
member of the Council of Vilnius Paediatric Society;
member of the Council of Lithuanian Paediatric Society;
member of Lithuanian Paediatric Cardiology Society.
Assoc.prof. V. Žilinskaitė –
board member of the Lithuanian Paediatric Intensive Care Society;
member of the European Society of Intensive Care Medicine;
editorial board member of the journal Pediatrija (Paediatrics);
Dr.I. Ivaškevičienė –
member of the Lithuanian Paediatric Society;
executive secretary of Baltic Immunoprophylaxis Association;
member of the European Society of Paediatric Infectious Diseases (ESPID);
member of the Young ESPID (European Society of Paediatric Infectious Diseases)
Society;
member of Central European Vaccination Advisory Group (CEVAG).
CLINIC OF INTERNAL MEDICINE, FAMILY PRACTICE AND ONCOLOGY
2 Santariškių, LT-08661 Vilnius
Phone / fax: +370 5 236 5075
E-mail: [email protected]
Head – prof.dr. Virginijus Šapoka
STAFF
Professors: Dr.V.Šapoka, Dr. V. Kasiulevičius, Dr. V. Alekna , Dr. L. Griškevičius, Dr. N.
Samalavičius, Dr.V.Ostapenko (part-time) .
Docents: Dr. V. Urbanavičius, Dr. (HP)E.Mišeikytė Kaubrienė, Dr.V.Dženkevičiūtė,
Dr.Ž.Visockienė (part-time), Dr.L.Vencevičienė (part-time)
Lecturers: Dr. A. Abraitienė, Dr. V. Pečeliūnas, Dr. A. Marcijonienė (part-time), Dr. K.
Simanauskas (part-time), N. Burokienė (part-time), Ž. Gudlevičienė (part-time)
Assistants: A. Slobinas (part-time), S.Tulytė (part-time), L.Vaitkevičiūtė (part-time),
D.Diglys (part-time), A.Galkinė (part-time)
Doctoral students: V. Andrejevaitė, R. Aškinis, A. Krasauskas, A. Urbanavičiūtė, R.
Gaidamovič, N. Lachej, R. Pileckytė, V. Dirsė, J. Mozūraitienė.
RESEARCH INTERESTS
Etiopathogenesis, Diagnostics, Treatment of Diseases: Fundamental and Clinical Research,
Innovative Technologies
Early Diagnostics and Prevention of Non-infection Diseases in Family Practice and in
Gerontology
Biomarker Research in Hematology and Oncology.
RESEARCH PROJECTS CARRIED OUT IN 2015
Projects Supported by University Budget
Early Diagnostics and Prevention of Non-Infection Diseases in Family Practice.
Prof.V.Šapoka, prof. V. Kasiulevičius. 2013 - 2018.
Relation of Cardiovascular Diseases Epidemiological Factors and Genome: the study in
the Lithuanian Population.
This study was to investigate the relation between cardiovascular diseases risk factors and
biochemical and genetic risk markers of atherosclerosis in the Lithuanian population.
Conclusions:
1. The study data showed, that 26.4% of individuals had a proper weight, one half (46.9%) of
Lithuanian adults were overweight, and 26.7 % had obesity. Our study suggests that on
average physical activity of traditional Lithuanian population is low-moderate. One third of
the study population does not routinely engage in the physical activity as basic as walking,
while up to one third would perform higher physical activity either at work or leisure. Family
history, particularly if mother or sisters have CVD, is important CVD risk factor.
2. The nutrition of most adult Lithuanians does not correspond with healthy nutrition
recommendations: insufficient consumption of vegetables, fruits, cereal products, fish and
fish products and overconsumption of meat and meat products.
3. The prevalence of dyslipidaemia - 94.2 %. Our study population had alarmingly high
levels of blood lipids with the average total cholesterol (TC) of 6.24 mmol/L and average of
LDL-C of 4.12 mmol/L.
4. Every third individual (37.7%) had the symptoms of clinical anxiety (HAD score was 8
points and above according to anxiety scale) and 17.5 % had symptoms of clinical
depression. Statistically important correlation between anxiety and CVD was found.
5. During the statistical analysis of genetic risk factors of CVD we have determined the
alleles’ frequencies of 61 SNPs and run the test of independence between the affected and
healthy subjects groups to determine the association. Six statistically significant differences
in alleles’ frequencies were found: rs2252641 (p=0.02), locus 2q22.3, ZEB2 gene, rs6903956
(p=0.01) locus 6p24.1, gene C6orf105, rs4773144 (p=0.03) loci 13q34 genes COL4A1/
COL4A2, rs2023938 (p=0.01), locus 7p21.1, HDAC9 gene, rs789335 (p=0.04), locus
10p12.31, CUBN gene and rs1751486 (p=0.01), loci 15q26.1 genes FURIN/FES . The
genetic association of those six SNPs and the CVD were shown and replicated independently
in other studies. All other remaining 55 SNPs selected for the analysis are also reported in the
literature as associated with CVD but there is no association found during this research. This
could be due to the sample size or the phenotype selected for the study. Nevertheless
rs2252641, rs6903956, rs2023938, rs4773144, rs789335, and rs1751486 could be the tag
SNPs for the risk definition (assessment) and specific markers for the general CVD
phenotype in the Lithuanian population.
Main publications
N. Burokienė, D.Karčiauskaitė, V.Kasiulevičius, V.Kučinskas, Z.A.Kučinskienė. Risk
assessment of cardiovascular diseases by assessing biochemical markers of atherosclerosis in
Lithuanian population. Laboratorinė medicina. 2015; 2(66): 47-52.
Evaluation and comparisson of disease outcomes in patients with acromegaly.
Evaluation and comparisson of disease outcomes in patients with acromegaly receiving first-
line and second-line (after transphenoidal surgery) somatostatin analogs (SSA) treatment
were performed. The study involved retrospective data collection from charts of 49 patients
with acromegaly who were consulted by an endocrinologist in Vilnius University Hospital
Santariskiu klinikos. Clinical findings include following symptoms and characteristics.
It was concluded that SSAs are more effective in the treatment of acromegaly when applied
after transphenoidal surgery, as they help to achieve control of the disease in a greater
percentage of patients. Although we observed higher mean observational period IGF-1 in the
first-line SSA treatment group as compared to second-line SSA therapy group, the difference
was not statistically significant. Control of the disease remains a challenge despite
availability of high-dose SSA treatment as 27-36% of patients receiving primary or second-
line SSA treatment remain uncontrolled. Study results were presented in the 17th European
Congress of Endocrinology, Dublin 2015 (Abstract no. EP726).
The relationship between lean mass, total and regional fat mass, bone mineral content,
bone mineral density in elderly.
Partial correlation analysis was performed and after controlling for age total body BMD,
lumbar spine BMD, femur neck BMD were positively associated with fat mass, android fat
mass in both groups. Partial correlation analysis was performed to determine if body
composition main variables were significantly related to total body BMD, site-specific BMD
after adjustment for age and weight for removing mechanical effect of loading. However after
adjustment for age and body weight fat mass was significantly negatively associated with
total body BMD and site-specific BMD. Android fat mass was negatively associated with
total body BMD and stronger with femur neck BMD in men. Partial correlation analysis
between fat mass and total body BMD showed weak inverse relationship in women. Gynoid
The multiple stepwise linear regression analysis models were designed to investigate the
influence of fat mass and regional fat distribution on total body BMD and site-specific BMD.
Fat mass negative influence on bone was observed in regression analysis.
Main publication:
Mastavičiūtė A, Alekna V, Tamulaitienė M, Strazdienė V. Fat mass, regional fat mass are
negatively associated with bone mineral density in elderly men and women. Central
European Journal of Medicine. 2015 (in process)
Values of oncological diseases and blood biological markers. Prof. L.Griškevičius, prof.
J.Didžiapetrienė. 2013-2018
Diffuse Large B Cell Lymphoma Study
A retrospective biomarker (IH, SNPa karyotyping) study on R-CHOP treated 100 DLBCL
has been completed and undergoind analysis.
Conclusions of Thyroid carcinoma study. Follow-up of the BRAF V600E mutation status in
the fine needle aspiration potentially may increase sensitivity in diagnostic of papillary
thyroid cancer. Even though the results are encouraging, larger scale prospective trials are
needed.
Development of molecular tool to identify thyroid follicular carcinoma among different
benign follicular lesions.
Progress: Patients with thyroid atypical follicular lesions (probability of follicular carcinoma)
are involved in the study and fine needle aspiration biopsies and patient vein blood is
collected and flash frozen for isolation of nucleic acids enriched in non-coding RNA. Fine
needle aspiration biopsy material undergoes cytological analysis. Patients after cytological
confirmation of probable/determined follicular carcinomas undergo thyroidectomy and
operation material undergoes histological analysis. Operation material, unused for
histological analysis is flash frozen for isolation of nucleic acids enriched in non-coding
RNA. Currently 6 cases of histologically confirmed follicular carcinoma and 36 cases of
benign follicular lesions are collected for further investigations.
In parallel three dimensional (3D) or conventional (2D) cancer cell line cultures are
cultivated and microenvironment dependent changes of gene and miRNR expression are
investigated using technologies of global analysis.
Main publication:
N. Dobrovolskienė, S. Cicėnas, N. Kazlauskaitė, E. Mišeikytė-Kaubrienė, J. A. Krasko, V.
Ostapenko, V. Pašukonienė, M. Strioga.CD8highCD57+T-cell population as an independent
predictor of response to chemoradiation therapy in extensive-stage small cell lung cancer.
Lung Cancer 90 (2015) 326–333.
In vivo reflectance confocal microscopy study to identify dysplasia of melanocytic nevus.
As morbidity of cutaneous melanoma increases, its early diagnosis and treatment become a
most important goal. According to the data from clinical studies, dysplastic nevus is
associated with elevated melanoma risks in three aspects: it shares similar features with
melanoma, it is a melanoma risk marker and it is a possible precursor of melanoma. An
accurate diagnosis of dysplastic nevus and cutaneous melanoma is important to lower
mortality and morbidity rates of cutaneous melanoma.
The progress of medical science provides new non-invasive diagnostic possibilities. In vivo
reflectance confocal microscopy offers live examination of skin morphology at the cellular
level. Hence, the aim of this study is to assess the accuracy of in vivo reflectance confocal
microscopy in the diagnosis of melanocytic dysplastic nevus.
The results of the study confirmed that features of melanocytic cutaneous lesions examined
by in vivo reflectance confocal microscopy correspond to features of cellular atypia in an
histological examination. Sensitivity and specificity of in vivo reflectance confocal
microscopy in the diagnosis of dysplastic nevi is insufficient to distinguish dysplastic nevi
from common nevi, but the accuracy of in vivo reflectance confocal microscopy is significant
in diagnosis of cutaneous melanoma.
Since the in vivo reflectance confocal microscopy examination improves the accuracy of
cutaneous melanoma diagnosis, it should be used when atypia of nevus is detected or
cutaneous melanoma is suspected.
OTHER SCIENTIFIC ACTIVITIES
Prof.V. Šapoka –
International and European Society of Internal Medicine, board member
journal Internistas (Internist), editor-in-chief
Lithuanian Evidence-Based Medicine Society, president
journals Medicinos teorija ir praktika (Theory and Practice in Medicine), Geriatrija
(Geriatrics) and Lietuvos bendrosios praktikos gydytojas (General Practitioner of
Lithuania),board member
Vilnius University Senate member
doc. V. Urbanavičius –
Eurodiabetes index 2015 committee, member
journals Lietuvos endokrinologija (Endocrinology of Lithuania), Medicinos teorija ir
praktika (Theory and Practice in Medicine), Diabetes Review and Internistas
(Internist), editorial board member
endocrinological conferences, member of the organizing commitees
European association of study of the diabetes, member
Prof. V. Kasiulevičius –
Lithuanian Society of General Practitioners, president
journal Internistas (Internist), editor
World Organization of Family Physicians and General Practitioners (WONCA), direct
member
UEMO (European Society of General Practitioner), head of Lithuanian delegation
Prof.V.Alekna-
Lithuanian Osteoporosis Foundation, President
Lithuanian Society of Gerontologists and Geriatrists, Vice- President
Journal Gerontologija (Lithuania), editor-in-Chief
INSTITUTE OF PUBLIC HEALTH
21/27 M.K. Čiurlionio, LT-03101 Vilnius
Tel. 239 8732, 239 8738
Fax 239 8738
E-mail:
Head – Prof. Dr. Rimantas Stukas
STAFF
Professors: Dr. R. Stukas, Dr. G. Šurkienė, Dr. J. Dadonienė, Dr. K. Žagminas, Dr. A.
Germanavičius, Dr. E. Gefenas
Associate professors: Dr. A. Astrauskienė (part-time), Dr. M. Jakubauskienė, Dr. V.
Giedraitis, Dr. J. Kairys (part-time), Dr. S. Vainauskas.
Lecturers: Dr. L. Ašoklienė (part-time), Dr. R. Bartkevičiūtė (part-time), Dr. A.
Bagdonavičius (part-time), A. Barzda (part-time), R. Baranauskienė (part-time), Dr. A.
Beržanskytė, D. Brogienė (part-time), Dr. M. Butikis, A. Čekanauskaitė (part-time) , Dr.
L.Murauskienė (part-time), Dr. E. Peičius (part-time), Dr. R. Sketerskienė (part-time), Dr. L.
Stundžė (part-time), Dr. A. Juodaitė – Račkauskienė (part-time), Dr. R. Vaitkienė (part-time),
Z. Javtokas (part-time), Dr. R. Jankauskas (part-time), Dr. J. Stanislavovienė, G. Smailytė
(part-time), V. Jaeck (part-time).
Research fellows: D. Austys (part-time), M. Baranauskas (part-time), Dr. A.Valiulis (part-
time).
Assistants: L. Paškevičius (part-time), N. Kuprevičienė (part-time), V. Taminskienė, J.
Lekstutienė (part-time), V. Dobrovolskij (part-time), N. Dambrauskaitė (part-time), I.
Kušeliauskaitė (part-time), Paulius Stravinskas (part-time).
Doctoral students: N. Kuprevičienė, D. Austys, V. Andreikėnaitė, I. Tamulaitytė -
Morozovienė, V. Taminskienė, I. Pačiauskaitė, A. Černovas, O. Ubartienė, D. Dudutienė, A.
Bilotienė, A. Motiejūnienė, S. Grublytė, L. Steponavičienė.
RESEARCH INTERESTS
Environmental and social factors and public health
History of medicine
Epidemiology of non-infectious and infectious diseases
Scientific basis of health care management
Assessment of health care activities and biostatistics
Health and quality of life
Medical ethics
RESEARCH PROJECTS CARRIED OUT IN 2015
Projects Supported by University Budget
Assessment of Health Risk Factors and Sense of Coherence of Elderly People. Prof. R.
Stukas. 2014 – 2018.
Data analysis of a questionnaire-based survey of elderly people was continued. 2 articles for
journals of ISI web of knowledge were prepared. The presentations in a scientific conference
on a basis of research results were prepared. Methodical material for the elderly people was
prepared. Students of public health master degree study program were involved into the
process of data analysis. Master thesis on basis of this research was prepared.
PhD thesis Peculiarities of health-determined life quality and subjective well-being of elderly
people is being prepared. This topic of research is developed by full time PhD student
Andrėjus Černovas.
Main publications:
1. Stukas R, Surkiene G, Cernovas A, Alekna V. Non-communicable diseases and
medication intake in institutionalized elderly. Eur J Pub Health. 2015; 25 Suppl
3:384-385 (stendinis pranešimas, 8th European Public Health Conference. October
14–17, 2015. Milan, Italy)
2. Tamulaityte-Morozoviene I, Alekna V, Stukas R, Surkiene G, Dadoniene J,
Tamulaitiene M. The self-reported psychological consequences of falls in elderly
women in Lithuania. Osteoporosis International with other metabolic bone diseases.
2015 Mar; Vol 26(1):P527.
Prevalence Study on Unintentional Domestic Injuries among Pre-School Children. Prof.
G. Šurkienė. 2014 – 2018.
Performed the anglysis of home related injuries among children under five attending
preschool education establishments in Lithuania.
Main publication:
Račaitė, J., Šurkienė, Jakubauskienė, M., Žiliūtė, E. The prevalence of home related injuries
among children under five attending preschool education establishments in Lithuania. Vaikų
pulmonologija ir alergologija. 2015, XVIII tomas, Nr. 2:7-14.
Ethical Aspects of Biomedical Reasearch with Human. Prof. E. Gefenas. 2009 –2015.
The aim of the project was to analyze ethical and legal aspects of biomedical research with
human biological materials. The database of Bibliography of Bioethics which gives a brief
bibliographical information about the articles published in Lithuanian and international
journals as well as legislation of Republic of Lithuania regulating ethical dilemmas in a
number of fields which involves a bioethical evaluation was updated. Issues with research
biological materials was dealt during seminar On the 9th – 16th of August in Belgrade.
International Science Programmes, Projects and Contracts
Education in Research Ethics: Central / Eastern Europe. Prof. E. Gefenas. 2004 – 2017.
In 2015 our Department continued collaboration with Union Graduate College Bioethics
Program (USA) in implementation of the project Advanced Certificate Program: Research
Ethics in Central and Eastern Europe. On the 9th – 16th of August the proseminar of
Advanced Certificate Program: E-Education in Research Ethics: Central and Eastern
Europe was held in Belgrade.Besides that was organised seminars:
1. Seminar Ethics of HIV research.
2. Seminar Advanced Certificate Program: Research Ethics in Central and Eastern Europe,
http://bioethics.uniongraduatecollege.edu/nih-grant/about
MAIN R&D&I (RESEARCH, DEVELOPMENT AND INNOVATION) PARTNERS
Lancaster University (UK)
Universidad de Deusto (Spain)
University of Verona (Italy)
Corvinus University of Budapest (Hungary)
Ministry of Health (Lithuania)
OTHER SCIENTIFIC ACTIVITIES
Prof. R. Stukas –
editorial college member of the journal Visuomenės sveikata (Public Health);
editorial board member of the journal Sveikatos mokslai (Health Sciences);
member of the National Health Board;
member of the Board of the Faculty of Medicine.
member of the board of the Lithuanian Ministry of Health
head of graduate and postgraduate study programmes Committee for Bachelor and
Master degree in Public Health;
board member of the Lithuanian Society of Hygienists and Epidemiologists;
Prof. G. Šurkienė –
editorial board member of the journal Visuomenės sveikata (Public Health);
editorial board member of the journal Sveikatos mokslai (Health Sciences);
member of the Lithuanian Society of Hygienists and Epidemiologists;
Chair of the Committee for Doctoral studies at Vilnius University in Public Health
Areas;
Public consultant to minister to health of Lithuania;
Member of graduate and postgraduate study programmes committee for Bachelor and
Master degree of Public Health
Prof. K. Žagminas –
member of editorial board of the journal Visuomenės sveikata (Public Health);
member of editorial board of the journal Medicinos teorija ir praktika (Theory and
Practice in Medicine);
member of the Lithuanian Society of Hygienists and Epidemiologists;
member of the Lithuanian Association for Infectious Diseases.
Prof. J. Dadonienė –
board member of Lithuanian Rheumatologist Association;
board member of Lithuanian Arthritis Association (patient organization);
member of European Network for Vasculitis Research (EUVAS);
member of organizing committee for the annual conference Vilnius Seminars in
Rheumatology;
member of organizing commitee of World Arthritis Day.
Assoc. Prof. E. Gefenas –
Co-director of the Advanced Certificate Program in Research Ethics in Central and
Eastern Europe sponsored by Union Graduate College Bioethics Program
(Schenectady, New York);
Member of the Council of Europe Steering Committee on Bioethics (CDBI);
Member of the bureau of the European Society for Philosophy of Medicine and
Health Care (ESPMH);
Member of the Board of Directors of the International Association of Bioethics (IAB);
Member of the advisory editorial board of the journals Medicine, Health Care and
Philosophy: A European Journal, (Springer);
International advisory board member of the journal Medical Humanities, (BMJ
Publishing Group).
Chairperson of the bureau of the Intergovernmental Bioethics Committee (IGBC).
Management Committee member of COST Action IS1201.
Prof. A. Germanavičius –
member of European Association of Psychiatrists;
board member of the European Network for Mental Health Service Research and
Evaluation (ENMESH);
member of the Committee on History of Psychiatry, World Federation of Biological
Psychiatry;
member of the Working Group in the History of Medicine, Brook University, Oxford,
UK;
member of Lithuanian Psychiatric Association (LPA);
president of Lithuanian Association for Psychosocial Rehabilitation;
editorial board member of the journal Medicina (Medicine);
editorial board member of the journal Sveikatos Mokslai (Health Sciences);
editorial board member of the journal Biologinė psichiatrija ir psichofarmakologija
(Biological Psychiatry and Psychopharmacology);
members of committee for strategic planning of mental health care development in
Lithuania 2008 –2013 at the Ministry of Health.
Dr. A. Čekanauskaitė –
member of the Lithuanian Bioethics Society;
member of the Board of the Foundation for Patient Safety, Innovations and Quality.
Dr. M. Jakubauskienė –
Vice president of the Public Mental Health Section of the European Public Health
association (EUPHA);
member of the Lithuanian Bioethics Society;
member of the Lithuanian Society of Young Researchers
member of the Board of Federation Global Initiative on Psychiatry
member of the National NGO and expert coalition on Mental Health
Leader of the international Research in Public Mental Health course
Dr. A. Beržanskytė –
national epidemiologist from Lithuania for European Antimicrobial Resistance
Surveillance Network (EARS).
Dr. V. Giedraitis –
coordinator, Erasmus Mundus Regional Health Master program;
editorial board member of the Journal of World-Systems Research;
managing editor of the journal Ekonomika (Economics).
Prof. A. Valiulis –
President of Lithuanian Paediatric Respiratory Society;
Vicepresident of Lithuanian Paediatric Society;
Chairman of Lithuanian Alliance Against Chronic Lung Diseases (WHO-GARD
Lithuania);
Vicechairman of Mother and Child Health Commission of Lithuanian Academy of
Sciences;
National coordinator in Strategic Pediatric Alliance for the Child Health in Europe;
National delegate at Global Asthma Initiative (GINA) and Global Allergic Rhinitis
Initiative (ARIA);
Chairman of Advisory Board of Lithuanian Council of Asthma Clubs;
Chief executive of IPOKRaTES Lithuania Fund;
Editor-in-Chief of the journal Paediatric Pulmonology and Allergology (Index
Copernicus);
Editor-in-Chief of the journal Lithuanian Paediatric Chronicle;
Editorial board member of the Paediatric Respiratory Reviews (ISI 2.676),
Pneumonologia i Alergologia Polska, Pediatria Polska, Russian Paediatric Journal;
Chairman of Vilnius International Paediatric Pulmonology Conference – School (20
annual international conferences of Paediatric Asthma, Pneumonia, CF, TB and
Orphan Lung Diseases; more than 8000 trained doctors);
Chairman of 4 Lithuanian National Asthma Congresses;
Chairman of 3 Lithuanian Congresses on Paediatric Pulmonology;
Chairman of 2 international conferences on Human Ecology;
Honorary fellow of British Royal College of Paediatrics and Child Health;
Member of Commissions of Rare Diseases, TB, Immunoprophylaxis, Mother &
Child, Suckling, Human Resources, Accessibility of Health Service of Lithuanian
Ministry of Health;
Chairman of Committee of Experts of Vaccination of Lithuanian Ministry of Health;
Chief Vilnius Paediatrician of Lithuanian Ministry of Health.
Assoc. Prof. J. Kairys –
editorial board member of the journal Sveikatos mokslai (Health Sciences);
Dr. R. Vaitkienė –
Representative of the Republic of Lithuania of the workshop on Health in All Policies
for Nordic and Baltic States: strenghtening capacity at national. Regional and local
level to work across sectors for Health equity and wellbeing, World Health
Organization Region Office for European, 2 December 2015, Copenhagen, Denmark
Member of the delegation of the Republic of Lithuania at the 65th session of the
World Health Organization Region Committee for European, September 14-17,
2015, Vilnius, Lithuania
Representative of the Republic of Lithuania of the session of Health Committee
Organization of Economic Cooperation and Development 24-27 June 2015, Paris,
France
Member of the delegation of the Republic of Lithuania of 51st session of the Public
Governance Committee Organization of Economic Cooperation and Development, 24
April 2015, Paris, France
Deputy member of the Administrative Commmission for the Coordination of Social
Security Systems, European Commission, since 2009, Brussels, Belgium
Dr. R. Jankauskas –
editorial board chair of the journal Visuomenės sveikata (Public Health).
R. Baranauskienė –
member of Social protection committee at European Commission;
associated partners Health Authorities representative in Orphanet Europe Joint
Action;
member of Council Working Party on Public Health at senior level
Dr. R. Bartkevičiūtė-
member of Food Quality and Safety Commission of Agricultural and Forestry
Sciences Division of Lithuanian Academy of Sciences;
member of Lithuanian Breastfeeding Committee.
Dr. R. Barzda-
member of Food Safety and Quality Commission of Agricultural and Forest Sciences
Department of Lithuanian Academy of Sciences;
representative of Republic of Lithuania in Codex Alimentarius Commis.
Dr. L. Murauskienė
Associate Editor for BMC Health Services Research
Dr. D. Brogienė
Coordinator, Erasmus Mundus Regional Health Master program;
Executive director of the Foundation for Patient Safety, Innovations and Quality;
Member of Lithuanian Society of Ostetricians and Gynaecologists. President of Legal,
Ethics and Competence evaluation commission;
Member of the Board of Lithuanian Doctors Association. President of Legal
commission;
Board member of CPME (The Standing Committee of European Doctors).
DEPARTMENT OF HUMAN AND MEDICAL GENETICS
DEPARTMENT OF HUMAN AND MEDICAL GENETICS
Santariškių str. 2, LT-08661 Vilnius
Tel. 250 1798, 250 1794
E-mail: [email protected]
www: http://www.genetika.mf.vu.lt
Head – Prof. (HP) dr. Algirdas Utkus
STAFF
Professors: Habil. Dr. V. Kučinskas (part-time), (HP) Dr. L. Cimbalistienė (part-time),
(HP)Dr. A. Utkus (part-time).
Associate professors: Dr. E. Benušienė (part-time), Dr. A. Jakaitienė (part-time), Dr. J.
Kasnauskienė (part-time), Dr. E.Pranckevičienė (part-time).
Lecturers: Dr. L. Ambrozaitytė (part-time), Dr. A. Molytė (part-time), Dr. V. Šliužas (part-
time).
Research fellows: Dr. Ž. Čiuladaitė (part-time), Dr. I. Domarkienė, Dr. V. Ginevičienė (part-
time), Dr. A. Matulevičienė (part-time), Dr. A. Morkūnienė (part-time), Dr. E. Preikšaitienė
(part-time), Dr. J. Songailienė (part-time), Dr. J. Sušinskas (part-time), Dr. I. Uktverytė, J.
Arasimavičius (part-time), I. Baškirova, B. Burnytė (part-time), Š. Germanas (part-time), R.
Meškienė, V. Mikštienė (part-time), A. Pranculis, T. Rančelis, B. Tumienė (part-time).
Assistants: B. Aleksiūnienė (part-time), A. Skučaitė (part-time).
Biologist investigator: A. Urnikytė.
Doctoral students: A. Pranculis, T. Rančelis, V. Mikštienė, B. Tumienė, B. Aleksiūnienė, B.
Burnytė, A. Urnikytė.
RESEARCH INTERESTS
Population Genetics of Lithuania
Genomics of Intellectual Disability
Genetic Basis of Imprinting Disorders
RESEARCH PROJECTS CARRIED OUT IN 2015
Projects Supported by University Budget
Diversity of Human Genome, Its Origin and Phenotypical Realization. Prof. (HP) Dr.
A.Utkus. 2014 – 2018.
National Research Projects
Research Council of Lithuania. Genetic diversity of the population of Lithuania and
changes of its genetic structure related with evolution and common diseases (LITGEN).
(No. VP1-3.1-ŠMM-07-K-01-013). Prof. Habil. Dr. V. Kučinskas. 2011 – 2015.
Whole exome sequencing of 33 samples and genome-wide SNP genotyping of 475
individuals from six ethnolinguistic groups of Lithuania were performed. The database of
whole exome sequencing data of 147 samples, whole genome sequencing data of 3 samples
and genome-wide SNP genotyping data of 475 samples was established (all data
impersonalized). Results of the LITGEN project has been presented in thesis, posters and oral
presentations, scientific publications. The main results and data (genome-wide genotyping,
whole exome and whole genome sequencing, Y chromosome genotyping and whole mtDNA
sequencing, biochemical profiling) of the LITGEN project were presented in the final
conference which was held on 6th
of March, 2015. During the conference the newest data and
results were presented by invited speaker’s prof. R. Jankauskas (Vilnius University), dr.
Giedrė Motuzaitė Matuzevičiūtė (Cambridge University) and dr. Alexandra P. Zhernakova
together with dr. Pieter Neerincx (Groningen University). Final report of the LITGEN project
was submitted and approved by the National Research Council.
Main publications:
1. Kushniarevich A, Utevska O, Chuhryaeva M, Agdzhoyan A, Dibirova K, Uktveryte I,
<…> Kucinskas V. <…> et al. Genetic Heritage of the Balto-Slavic Speaking
Populations: A Synthesis of Autosomal, Mitochondrial and Y-Chromosomal Data.
PLoS ONE, 2015; 10(9): e0135820. doi:10.1371/journal.pone.013582.
2. Pranckevičiene E, Rančelis T, Pranculis A, Kučinskas V. Challenges in exome
analysis by LifeScope and its alternative computational pipelines. BMC research
notes. London, Biomed Central. ISSN 1756-0500. Vol. 8, no 1. 2015. art no 421 [1-
15].
International Research Projects
Unique genome variants in congenital neurodevelopmental disorders: origin, genomic
mechanisms, functional and clinical consequences (UNIGENE). (No. CH-3-ŠMM-01/04).
Prof. Habil. Dr. V. Kučinskas. 2012 – 2016.
All relevant information for 145 patients (i.e.127 families) with intellectual disability and
their family members was uploaded into the database. The molecular genetic analysis using
array-based comparative genomic hybridization and next generation sequencing using whole
exome and genome sequencing approach was completed. Analysis was performed using the
optimized algorithm. Variants in potential candidate genes were identified. Clinically
significant changes were identified and published.
Main publications:
1. Preiksaitiene E, et al. Novel Missense Mutation in the NSDHL Gene Identified in a
Lithuanian Family by Targeted Next-generation Sequencing Causes CK Syndrome. Am J
Med Genet 2015 Apr 21.
2. Preikšaitienė E, Benušienė E, Matulevičienė A, Grigalionienė K, Utkus A, Kučinskas V.
p.Lys106Glu Mutation of SOX9 Gene Causes Acampomelic Campomelic Dysplasia:
Prenatal and Postnatal Clinical Findings. Am J Med Genet 2015 11.
TAIWAN-LATVIA-LITHUANIA COOPERATION PROJECT
Functional model for the mitochondrial disease evaluation and biomarker development.
Reference No.: TAP LLT-02/2015. Prof. (HP) dr. Algirdas Utkus. 2015 - 2017.
Recruitment of the patients with suspected or confirmed mitochondrial disorders and the
control group, mtDNA sequencing, and copy number analysis of patients and cybrid creation
were performed in 2015. Platelets collected from blood samples of 37 Lithuanians were fused
with Rho0 (ρ0) 143B osteosarcoma cells without functional mtDNA at Department of
Medical Research Kaohsiung Chang-Gung Memorial Hospital during junior researchers
traineeship. The quality of cybrid cells was ensured by several procedures such as mtDNA
copy number determination. Cybrids were frozen at –80°C and stocked for further
experiments.
MAIN R&D&I (RESEARCH, DEVELOPMENT AND INOVATION) PARTNERS
Thermo Fisher Scientific Baltics (Lithuania)
National Cancer Institute (Lithuania)
Lithuanian Olympic Sports Center (Lithuania)
University of Lausanne (Swiss Confederation)
Department of Medical Research Kaohsiung Chang-Gung Memorial Hospital (Taiwan,
China)
OTHER SCIENTIFIC ACTIVITIES
Prof. A. Utkus –
editorial board member of the journal Laboratorinė medicina (Laboratory Medicine),
http://www.llmd.ip.lt/lm;
member of the Lithuanian Society of Human Genetics,
http://www.geneticahumana.lt/LZGD/organizacija.htm;
President of the Lithuanian Society of Human Genetics,
http://www.geneticahumana.lt/LZGD/organizacija.htm;
editorial board member of the journal Sveikatos mokslai (Lietuva);
member of the European Society of Human Genetics (board member of Education
Committee of ESHG), www.eshg.org;
chairman of the Council of the Faculty of Medicine of Vilnius University;
dean of the Faculty of Medicine, Vilnius University;
member of the Rectorate of Vilnius University;
board member of Ministry of Health of the Republic of Lithuania;
member of the Lithuanian National Committee on Biomedical Ethics,
http://www.sam.lt/bioetika/;
Prof. V. Kučinskas –
Full member of the Lithuanian Academy of Sciences,
http://lma.lt/intranetas/index.php?m=profile&user=309;
editorial board member of the journal Laboratorinė medicina (Laboratory Medicine),
http://www.llmd.ip.lt/lm/;
editorial board member of the Journal of Applied Genetics (Poland),
http://www.jay.au.poznan.pl/JAG/;
editorial board member of the journal Medicina (Medicine);
editorial board member of the Journal Medical Genetics (Russia);
editorial council member of the Journal Acta medica Lituanica;
editorial board member of the Balkan Journal of Medical Genetisc (Makedonija);
consultant on medical genetics, Ministry of Health of the Republic of Lithuania;
board member of the Lithuanian Society of Human Genetics,
http://www.geneticahumana.lt/LZGD/organizacija.htm;
member of the European Society of Human Genetics (board member of Education
Committee of ESHG), www.eshg.org;
member of the American Society of Human Genetics, www.ashg.org;
member of Human Genome Organization (HUGO);
Prof. L. Cimbalistienė –
member of the Society for the Study of Inborn Errors of Metabolism (SSIEM),
http://www.ssiem.org;
member of the Lithuanian Society of Human Genetics (chairperson of Committee of
Financial Supervisory Commission),
http://www.geneticahumana.lt/LZGD/organizacija.htm;
member of the Lithuanian Doctors’ Union, http://www.lgs.lt/;
Dr. J. Kasnauskienė –
member of the Lithuanian Society of Human Genetics,
http://www.geneticahumana.lt/LZGD/organizacija.htm;
member of the European Society of Human Genetics, www.eshg.org;
board member of Lithuanian Society of Laboratory Medicine;
Dr. E. Pranckevičienė –
member of the European Society of Human Genetics, www.eshg.org;
Dr. E. Benušienė –
member of the Lithuanian Society of Human Genetics (chairperson of Committee of
Professional Competence and Ethics),
http://www.geneticahumana.lt/LZGD/organizacija.htm;
member of the European Society of Human Genetics, www.eshg.org;
Lithuanian Society of Doctors.
Dr A. Jakaitienė –
member of Lithuanian Mathematical Society, http://www.mif.vu.lt/lmd/index.html;
member of Lithuanian Statistics Society, http://www.statistikusajunga.lt/;
member of International Epidemiological Association.
Dr. A. Matulevičienė –
member of the European Society of Human Genetics, www.eshg.org;
member of the Committee for Orphan Medicinal Products (COMP),
http://www.emea.europa.eu/htms/general/contacts/COMP/COMP_members.html;
member of the Lithuanian Society of Human Genetics, (board member of the
Committee of Financial Supervisory Commission),
http://www.geneticahumana.lt/LZGD/organizacija.htm;
member of the Lithuanian Society of Doctors;
Dr. A. Morkūnienė –
member of the Lithuanian Society of Human Genetics;
http://www.geneticahumana.lt/LZGD/organizacija.htm;
member of the European Society of Human Genetics, www.eshg.org;
COST Action BM1208 (European Network for Human Congenital Imprinting
Disorders) group member;
Dr. J. Sušinskas –
member of the Lithuanian Mathematical Society,
http://www.mif.vu.lt/lmd/index.html;
Dr. J. Songailienė –
member of the Lithuanian Society of Human Genetics,
http://www.geneticahumana.lt/LZGD/organizacija.htm;
member of the International Society for Neonatal Screening http://www.isns-
neoscreening.org/ ;
member of the Society for the Study of Inborn Errors of Metabolism (SSIEM),
http://www.ssiem.org;
president of the Baltic Metabolic Group
http://www.ssiem.org/nationalsocieties/membercountriesdetails.asp?cid=30
National representative of Lithuania in ERNDIM/EuroGenTest (ERNDIM- European
Research Network for Evaluation and Improvement of Screening, Diagnosis and
Treatment of Inherited Disorders of Metabolism; EuroGentest - EU-funded Network
of Excellence), http://www.erndim.unibas.ch;
Dr. V. Ginevičienė –
member of the Lithuanian Society of Human Genetics,
http://www.geneticahumana.lt/LZGD/organizacija.htm;
member of the European Society of Human Genetics, https://www.eshg.org/;
member of the European College of Sport Science, http://www.ecss.mobi/;
member of the Baltic Sport Science Society,
www.leu.lt/download/6594/bsss_sutartis.pdf;
member of the Lithuanian Federation of Sports Medicine, http://www.lsmf.lt/
Dr. V. Šliužas –
member of the Lithuanian Society of Human Genetics,
http://www.geneticahumana.lt/LZGD/organizacija.htm;
member of the European Society of Human Genetics, www.eshg.org;
Dr. L. Ambrozaitytė –
member of the Lithuanian Society of Human Genetics, (board member of Committee
of Professional Competence and Ethics),
http://www.geneticahumana.lt/LZGD/organizacija.htm;
member of the European Society of Human Genetics, www.eshg.org;
member of the American Society of Human Genetics;
COST Action BM1208 (European Network for Human Congenital Imprinting
Disorders) group member;
Dr. I. Domarkienė –
member of the Lithuanian Society of Human Genetics,
http://www.geneticahumana.lt/LZGD/organizacija.htm;
member of the European Society of Human Genetics, www.eshg.org;
Dr. A. Molytė –
member of the Lithuanian Computer Society,
http://www.liks.lt;
Dr. Ž. Čiuladaitė –
member of the Lithuanian Society of Human Genetics,
http://www.geneticahumana.lt/LZGD/organizacija.htm;
member of the European Society of Human Genetics, www.eshg.org;
National scholarship program of the World Federation of Scientists,
http://www.federationofscientists.org/ ;
Dr. E. Preikšaitienė –
member of the Lithuanian Society of Human Genetics,
http://www.geneticahumana.lt/LZGD/organizacija.htm;
member of the European Society of Human Genetics, www.eshg.org;
Fellowship for the Young Scientists of Lithuanian Academy of Sciences 2015-2016.
Dr. I. Uktverytė –
member of the Lithuanian Society of Human Genetics,
http://www.geneticahumana.lt/LZGD/organizacija.htm;
member of the European Society of Human Genetics, www.eshg.org;
Prize of the Lithuanian Academy of Sciences for Research of Young Scientists, 2015,
www.lma.lt
B. Aleksiūnienė –
member of the Lithuanian Society of Human Genetics,
http://www.geneticahumana.lt/LZGD/organizacija.htm;
member of the European Society of Human Genetics, www.eshg.org;
B. Burnytė –
member of the Lithuanian Society of Human Genetics,
http://www.geneticahumana.lt/LZGD/organizacija.htm;
member of the Society for Studies of Inborn Errors of Metabolism, SSIEM,
http://www.ssiem.org;
Orphanet information scientist, http://www.orpha.net;
V. Mikštienė –
member of the Lithuanian Society of Human Genetics,
http://www.geneticahumana.lt/LZGD/organizacija.htm;
member of the European Society of Human Genetics, www.eshg.org;
R. Meškienė –
member of the Lithuanian Society of Human Genetics,
http://www.geneticahumana.lt/LZGD/organizacija.htm;
A. Pranculis –
member of the European Society of Human Genetics, www.eshg.org;
member of the Lithuanian Society of Human Genetics,
http://www.geneticahumana.lt/LZGD/organizacija.htm;
B. Tumienė –
member of the Lithuanian Society of Human Genetics,
http://www.geneticahumana.lt/LZGD/organizacija.htm;
member of the Society for Studies of Inborn Errors of Metabolism, SSIEM,
http://www.ssiem.org;
board member of Baltic Metabolic Group, http://www.ssiem.org;
member of Lithuanian Child Neurology Association, www.neuroseminarai.lt;
member of Lithuanian Society of Epileptology, tel. (8 5) 2365109;
member of Lithuanian Society of Neurosciences, www.neuromokslai.lt;
Orphanet information scientist, www.orpha.net;
A. Skučaitė –
member of the Lithuanian Mathematical Society,
http://www.mif.vu.lt/lmd/index.html;
