Faculty Fall 2019 NON-CST Faculty Research Projects 2020 Non-CST... · biology courses (with lab). Having taken organic chemistry 1 or biochemistry Biochemistr y, Chemistry, Biology,

Fall 2019 NON-CST Faculty Research ProjectsFaculty

Name

Email

Address

Faculty

School or

College

Faculty

Department

Project title Description Project

Location

Important

selection

criteria

Student

Majors

Desired

Santiago

Orrego

sorrego@te

mple.edu

Dental

School

Restorative

Dentristry

and

Bioengineerin

g

Smart

Biomaterials for

Dental and

Bone

Applications

In our research project, we develop novel biomaterials with smart

functionalities. We are focusing on biomaterials that kill bacteria and

viruses, therefore, offering anti-infection capabilities. In addition, our

biomaterial can regenerate tissue (e.g. bone) by activating the

formation and growth of minerals. Our materials could be implanted

in the body without any infection and by promoting regeneration of

tissue. Our interdisciplinary work merges areas of bioengineering,

microbiology and materials science. In our lab, we conduct

experiments by preparing novel biomaterials to exposed them to

body-like conditions with cells, viruses and bacteria. Our biomaterials

also can delivery drugs after activated by specific body signal.

TUHSC We are

seeking

talented and

self-

motivated

candidates

with a good

work ethics.

Discipline,

commitment

and

excellent

communicati

on are a

must!

Bioenginee

ring,

Mechanical

Engineering

, Chemistry,

Biochem

Bojana

Gligorijevic

bojana.glig

orijevic@te

mple.edu

Engineering BioEngineerin

g

Cancer

Bioengineering

and Cancer

Microscopy

Student would use multiphoton and confocal fluorescent

microscopes to image cancer cells labeled with 3 different

fluorescent proteins. The goal is to compare how motility of cells

relates to cell cycle stage distribution in 3D cellular spheroids

embedded in collagen matrix. We hypothesize that cells which are

motile will be arrested in G1 stage and that spatially, such cells will

be positioned in the rim of the spheroid. The results have an

application in the field of cancer drug resistance, which is the main

cause of remission today.

Main use of

microscopes,

sterile cell

culture, cell

transfection

and

transduction

, PCR,

microarrays,

immunofluo

rescence or

histology...

Biochemistr

y,

biophysics,

natural

sciences,

pre-health

10/24/2019 1


Name

Email

Address

Faculty

School or

College

Faculty

Department


Location

Important

selection

criteria

Student

Majors

Desired

Won Suh whs@temp

le.edu

Engineering Bioengineerin

g

Culture of

mammalian

cells embedded

in synthetic

hydrogels

under flow

conditions

(micro/macrofl

uidics)

Mammalian cells such as PC12 and human neural stem cells (hNSCs)

will be embedded in synthetic (polymeric) hydrogels. The first steps

involve producing synthetic hydrogels and learning basic cell culture

techniques. The ultimate goal is to assess the fate of cells embedded

in the 3D matrix. The viability and differentiation profiles of hNSCs,

for instance, will be assessed utilizing live-cell imaging,

immunocytochemistry, and protein analysis. Data analysis methods

will involve ImageJ processing and inferential statistical analysis

methods utilizing Matlab or JMP software programs.

Main No prior lab

experience

required.

Pre-requisite

courses are,

at least, two

basic

chemistry

and/or

biology

courses

(with lab).

Having taken

organic

chemistry 1

or

biochemistry

Biochemistr

y,

Chemistry,

Biology,

Neuroscien

ce

Won Suh whs@temp

le.edu


g

Synthesis of

amphiphilic

peptides for

drug delivery

Short (3-30 mer) peptide sequences will be synthesized via solid-

phase peptide synthesis (SPPS) methods. Post-modification of

peptides will involve saturated and unsaturated hydrocarbons.

Characterization will be performed via NMR and Mass Spectrometry

methods after separation of molecules via HPLC (High-Performance

Liquid Chromatography). Depending on the success of the peptide

synthesis, live-cell experiments will be conducted to test the

peptide's bioactivity.

Main No prior lab

experience

required.

Pre-requisite

courses are,

at least, two

basic

chemistry

and/or

biology

courses

(with lab).

Having taken

organic

chemistry 1

or

biochemistry

Biochemistr

y,

chemistry,

biology,

neuroscien

ce

10/24/2019 2


Name

Email

Address

Faculty

School or

College

Faculty

Department


Location

Important

selection

criteria

Student

Majors

Desired

Won Suh whs@temp

le.edu


g

Synthesis of

polymeric

particles for

tissue

engineering

Microparticles (1-500 microns) and nanoparticles (sub-micron)

comprising polyesters, polyamides, and polyethers will be produced

via emulsion and ultrasonic methodologies. Bioactive molecules such

as growth factors and hydrophobic drugs will be encapsulated and

tested for their cytotoxicities. Microscopy methods and ImageJ

processing will allow for characterization. Statistical analysis involving

ANOVA (analysis of variance) and t tests will be conducted utilizing

Matlab or JMP software. Depending on the progress of particle

synthesis and in vitro testing results, the research can be expanded

to tissue engineering applications.

Main No prior lab

experience

required.

Pre-requisite

courses are,

at least, two

basic

chemistry

and/or

biology

courses

(with lab).

Having taken

organic

chemistry 1

or

biochemistry

Biochemistr

y,

chemistry,

biology,

neuroscien

ce

Won Suh whs@temp

le.edu


g

Production of

green

fluorescent

proteins

Green fluorescent proteins will be produced from plasmids both in

bacterial cells and mammalian cells. Post-translational modification

such as amination, esterification, and carbamation will be conducted

as well. Characterization will involve gel electrophoresis after

chromatographic separation (e.g., HPLC). Live-cell experiments

utilizing a fluorescence microscope equipped with a stage-top

incubator will be conducted to test the GFP's biocompatibility. Data

analysis methods will involve ImageJ processing and inferential

statistical analysis methods utilizing Matlab or JMP software

programs.

Main No prior lab

experience

required.

Pre-requisite

courses are,

at least, two

basic

chemistry

and/or

biology

courses

(with lab).

Having taken

organic

chemistry 1

or

biochemistry

Biochemistr

y,

chemistry,

biology,

neuroscien

ce

Gangadhar

Andaluri

gangadhar

@temple.e

du

Engineering Civil and

Environmenta

l

Analytical

Testing and

Adsorbent

Preparation

Assist in the development of Analytical methods and sample Analysis.

The scope of work includes analysis on LC/MS/MS, GC/MS, BET, TOC,

FTIR, IC and any other equipment as applicable etc.

Main Chemistry

Lab

experience a

plus

Environme

ntal

Engineering

10/24/2019 3


Name

Email

Address

Faculty

School or

College

Faculty

Department


Location

Important

selection

criteria

Student

Majors

Desired

Gangadhar

Andaluri

gangadhar

@temple.e

du


Environmenta

l Engineering

Analysis of

emerging

contaminants in

environmental

matrices

Develop analytical methods for the analysis of emerging

contaminants (such as PFAS) in environmental matrices using

advanced liquid/gas chromatography techniques.

Main

Campus

Wet

Chemistry

lab

experience

Chemistry,

Biochem,

Bio

Rominder

Suri

rominder.s

uri@templ

e.edu


Environmenta

l Engineering

Degradation of

Organic

Pollutants from

Water and

Wastewater by

Advanced

Oxidation

Processes

Developing and validating analytical procedures by EMD

performance materials. Extraction methods may be involved during

analysis of analytes. Evaluation of degradation of organic pollutants

which are environmentally concerned from water and wastewater

using advanced oxidation processes.

Main Chemistry

background

is

preferable.

Chemistry

Muruganan

dham

Manickavac

hagam

tud20497@

temple.edu

Engineering Environmenet

al Engineering

Technology

development

for water and

wastewater

treatment

The Water and Environmental Technology (WET) Center (funded by

National Science Foundation and Industry), Department of Civil and

Environmental Engineering, Temple University focused to address

issues related to water and wastewater. The primary research

related to (1) Physico-chemical water and wastewater treatment

processes, 2) Analytical methods development for emerging

compounds, and 3) bio-chemical water and wastewater treatment

process.

Main environme

ntal

science/en

gineering

and or

Chemistry

background

Rominder

Suri

rominder.s

uri@templ

e.edu

Engineering Environmenet

al Engineering

Electro-

oxidative

Transformation

of Perfluoro

carboxylic acids

(PFCAs)

The electrochemical oxidation behaviour of PFCAs, determination of

optimum operation parameters, by-products formation.

Main interest in

the

project/rese

arch, critical

thinking,

problem

solving skills.

Chemistry,

physics,

engineering

10/24/2019 4


Name

Email

Address

Faculty

School or

College

Faculty

Department


Location

Important

selection

criteria

Student

Majors

Desired

Rominder

Suri

rominder.s

uri@templ

e.edu

Engineering Environmenta

l engineering

Advanced

oxidation

processes for

emerging

contaminants

removal from

water

Investigation of emerging contaminant removal by

different/combined advanced oxidation processes.

Main interest in

the

project/rese

arch, critical

thinking,

problem

solving skills.

Chemistry,

engineering

Mohamma

d Kiani

mkiani@te

mple.edu

Engineering Mechanical

Engineering

Does low doses

of ionizing

radiation

damage DNA in

HUVECs.

The effects of low and high doses of ionizing radiation on human

umbilical vein endothelial cells will be determined using cell

proliferation and comet assays.

Main Some

experience

in any lab

setting

Biology,

Engineering

Richard

Katz

Richard.Kat

[email protected]

FCCC Fox Chase

Cancer Center

Organization of

chromatin

within the cell

nucleus

The most striking feature of the eukaryotic nucleus is the spatial and

functional organization of chromatin into two fundamental units:

euchromatin (open, active) and heterochromatin (closed, Inactive).

Heterochromatin is localized largely in a compartment at the inner

nuclear periphery, in association with the fibrous nuclear lamina

framework. An emerging concept, based on evidence from C. elegans

and mammals, is that heterochromatic histone tail modifications, e.g.

H3K9me3, serve as anchoring points for the attachment of

heterochromatin to the nuclear periphery. A second well-supported

concept is “tethering”, whereby proteins serve to attach

heterochromatin to the nuclear periphery. In mammals, two

proteins, LBR and PRR14, have been implicated in H3K9me2/3-

dependent tethering of heterochromatin to the nuclear lamina.

PRR14 acts as a modular bivalent tether to link the nuclear lamina to

the heterochromatin protein 1 (HP1) adapter protein and its

H3K9me3/H3K9me2 ligands. We found unexpectedly that the N-

terminal heterochromatin binding domain of the PRR14 localizes

only with H3K9me3. Using a variety of imaging and cellular

biochemical methods, the project will be to investigate the

comparative specificities of PRR14 and LBR for H3K9me2 and

H3K9me3 in mammalian cells.

FCCC Biology

10/24/2019 5


Name

Email

Address

Faculty

School or

College

Faculty

Department


Location

Important

selection

criteria

Student

Majors

Desired

Richard

Katz

Richard.Kat

[email protected]

FCCC Fox Chase

Cancer Center

Organization of

chromatin

within the cell

nucleus

The most striking feature of the eukaryotic nucleus is the spatial and

functional organization of chromatin into two fundamental units:

euchromatin (open, active) and heterochromatin (closed, Inactive).

Heterochromatin is localized largely in a compartment at the inner

nuclear periphery, in association with the fibrous nuclear lamina

framework. An emerging concept, based on evidence from C. elegans

and mammals, is that heterochromatic histone tail modifications, e.g.

H3K9me3, serve as anchoring points for the attachment of

heterochromatin to the nuclear periphery. A second well-supported

concept is “tethering”, whereby proteins serve to attach

heterochromatin to the nuclear periphery. In mammals, two

proteins, LBR and PRR14, have been implicated in H3K9me2/3-

dependent tethering of heterochromatin to the nuclear lamina.

PRR14 acts as a modular bivalent tether to link the nuclear lamina to

the heterochromatin protein 1 (HP1) adapter protein and its

H3K9me3/H3K9me2 ligands. We found unexpectedly that the N-

terminal heterochromatin binding domain of the PRR14 localizes

FCCC Biology

10/24/2019 6


Name

Email

Address

Faculty

School or

College

Faculty

Department


Location

Important

selection

criteria

Student

Majors

Desired

Eileen Jaffe eileen.jaffe

@fccc.edu

FCCC Molecular

Therapeutics

Optimizing the

formation of

phenylalanine

hydroxylase

crystal

formation.

One overarching goal of the Jaffe lab is to understand how anomalies

in the structure and function of the enzyme phenylalanine

hydroxylase (PAH) contributes to phenylketonuria, the most

common inborn error of amino acid metabolism. The undergraduate

will be tasked with optimizing protein crystallization of human PAH,

with the ultimate goal of generating diffraction quality crystals for

crystal structure determination. The student will work under the

direct supervision of a highly experience Research Associate, Dr.

Michael Hansen. The laboratory has successfully purified sufficient

wild type hPAH (and designed variants) and Dr. Hansen has identified

several conditions resulting in 50 μm crystals using the hanging drop

vapor diffusion technique. Preliminary diffraction data (~3.5 Å),

obtained at a synchrotron light source, suggests that higher

resolution data may result from optimization of the crystallization

condition. Optimization involves systematic variation of the

crystallization conditions such as selection of precipitant, precipitant

concentration, salt, pH, and buffer. The student will prepare all stock

solutions, prepared the protein, mix the crystallization droplet, and

use light microscopy to evaluate crystal formation with time (e.g. 1-

10 days). The student will be required to keep precise records and is

expected to contribute to the experimental design after a few weeks.

The student will also master the technique of crystal seeding, which

can control the number of crystals grown and increase crystal size. In

addition, the student will be expected to participate in the

heterologous expression of hPAH and variants, and in purifying the

protein using rapid affinity purification method. Both methods are

well established in the Jaffe lab.

FCCC Excellent

performance

in

introductory

chemistry

and the

associated

laboratory

Chemistry

or

Biochemistr

y

John

Karanicolas

john.karani

colas@fccc.

edu

FCCC Molecular

Therapeutics

Developing

potent

inhibitors of

RNA-binding

protein Msi2

RNA-binding proteins play important roles in many different

diseases, including cancer. We have designed inhibitors of the RNA-

binding protein Musashi2 (Msi2), a key driver in pancreatic cancer.

While these first inhibitors are effective in cells, they are not yet

potent enough to be advanced into animals for further testing. Thus,

we would like to make several derivatives of these first compounds,

so that we can ultimately test whether they are effective in animals.

FCCC Must have

completed

organic

chemistry II

Chemistry

or Biochem

10/24/2019 7


Name

Email

Address

Faculty

School or

College

Faculty

Department


Location

Important

selection

criteria

Student

Majors

Desired

Seonhee

Kim

tue62079@

temple.edu

LKSOM Anatomy and

Cell Biology

The role of cell

signaling and

polarity in

neural

development

My laboratory’s research focuses is to understand the molecular and

cellular mechanisms controlling brain development to study the basis

of neurodevelopmental disorders. To gain in-depth knowledge of

neural development and neuronal disorders, we utilize

multidisciplinary approaches such as molecular and neuroanatomical

techniques including gene cloning, progenitor or neuronal culture,

cortical electroporation and time-lapse imaging of cortical explants.

Students will involve the characterization of animal models exhibiting

TUHSC Biology

Shin Kang shin.kang@

temple.edu

LKSOM Anatomy and

Cell Biology

Effects of glial

regeneration

promotion on

the disease

course of ALS

Unknown glial mechanisms contribute to ALS, a devastating motor

neuron disease. We recently found that a specific genetic

manipulation that enhances oligodendroglia cell regeneration

significantly extends the survival period of ALS mice. This project will

investigate whether the same manipulation slows disease

progression and attenuates symptoms and biochemical indices of the

disease. Good organization skill and professional attitude.

TUHSC Interest in

the study of

neurodegen

erative

diseases.

Experimenta

l mouse

handling

may be

required.

Strong

knowledge

of biological

concepts.

Biology-

related

sciences

Shin Kang shin.kang@

temple.edu

LKSOM Anatomy and

Cell Biology

What happens

to the adult

brain after

specific ablation

of blood vessel

pericytes?

Brain pericytes are an integral part of blood-brain-barrier and are

thought to make brain capillary contractile. We engineered a unique

genetic system to induce pericyte ablation in the adult mouse brain.

The goal of this project is to characterize brain samples after pericyte

ablation is induced. Strong knowledge of biological concepts. Good

organization skill and professional attitude.

TUHSC Interest in

the study of

neurodegen

erative

diseases.

Experimenta

l mouse

handling

may be

required.

Biology-

related

sciences

10/24/2019 8


Name

Email

Address

Faculty

School or

College

Faculty

Department


Location

Important

selection

criteria

Student

Majors

Desired

Ana

Gamero

gameroa@t

emple.edu

LKSOM Biochemistry STAT2 Signaling

in Cancer

STAT2 is a transcription factor widely recognized for its role in host

defense against microbial attack and inflammation. Published work

from my laboratory now suggests that STAT2 is also implicated in

cancer development. We have evidence in animal models of cancer

that STAT2 functions to promote tumorigenesis. Based on this

exciting finding, the main objective of my lab is determine the

underlying molecular mechanism by which STAT2 is promoting

cancer development. Able to work well with others

TUHSC Strong

knowledge

of biological

concepts

Self-

motivated

and

willingness

to work hard

Biology,

Biochemistr

y

Ana

Gamero

gameroa@t

emple.edu

LKSOM Biochemistry Understanding

the Role of

STAT2 in

Colorectal

Cancer

Cancer is a very complex disease driven by multiple genetic

alterations. The focus of my research is to investigate the mechanism

by which the transcription factor STAT2 promotes tumor progression

in colorectal cancer. The long-term goal of this project is to

determine how STAT2 cooperates with tumor oncogenes to enable

tumor progression, conversion of benign lesions to malignant and

metastasis. Understanding this process will lead to the development

of novel therapeutic interventions to treat colorectal cancer.

TUHSC Good

communicati

on skills,

attention to

detail and

able to

follow

directions

Biology,

Biochemistr

y

Madesh

Muniswam

y

yson@tem

ple.edu

LKSOM Biochemistry MCU gene

knockout using

zebra fish

model system

We are creating a knockout zebra fish for the mitochondrial calcium

uniporter (MCU) gene using Crispr/Cas9. We plan to breed the

homozygotes for the MCU deletion and then use them for functional

analyses. The goal is to measure how the deletion of MCU affects the

ATP production/Calcium handling/Oxidative stress in the

mitochondria.

TUHSC Prior

experience

in a

Biology/Life

Science Lab

Good

Laboratory

Practice

General

curiosity Bio

1, Bio 2,

Genetics

Biology,

Biochemistr

y,

Molecular

Biology

10/24/2019 9


Name

Email

Address

Faculty

School or

College

Faculty

Department


Location

Important

selection

criteria

Student

Majors

Desired

Thomas E

Sharp

tuc72715@

temple.edu

LKSOM Cardiovascula

r Research

Therapeutic

Potential of Cell

Based Therapy

in the Swine

Heart after

Myocardial

Infarction

Novel therapies are needed to improve cardiac function after MI;

one strategy is to replace lost myocardium. Despite the success of

bone marrow- and cardiac- stem cell clinical trials, we’re still

searching for the optimal stem cell type most suitable for

preservation of existing myocardium and cardiac regeneration.

Previously, we described a novel cell population derived from the

cortical bone (CBSCs) which repaired the heart post MI via

transdifferentiation and paracrine signaling mechanisms in a mouse

model. In the present study, we evaluate the translational potential

of CBSCs in swine post MI.

TUHSC Biology,

Chemistry,

Biochemistr

y,

Neuroscien

ce

Abdelkarim

Sabri

sabri@tem

ple.edu

LKSOM Cardiovascula

r Research

Center

Inflammatory

proteases and

cardiac repair

In the adult heart, cell death following myocardial infarction initiates

an inflammatory reaction that removes dead cells and contributes to

scar formation and cardiac repair. Since the regenerative capacity of

the adult mammalian heart is limited, induction of this innate

immune response could be maladaptive and compromises cardiac

contractile function. Our study uses a combination of in vivo and in

vitro model systems to define the role of inflammatory proteases on

endogenous cardiac repair and function after myocardial infarction.

TUHSC Basic cell

and

molecular

biology

techniques.

Highly

motivated

students

with sound

knowledge

in cell and

molecular

biology.

Biochemistr

y

10/24/2019 10


Name

Email

Address

Faculty

School or

College

Faculty

Department


Location

Important

selection

criteria

Student

Majors

Desired

Victor Rizzo rizzov@te

mple.edu

LKSOM Cardiovascula

r Research

Center

The role of

extracellular

vesicles in

vascular disease

Atherosclerosis, hypertension and aneurysms are the major causes of

cardiovascular disease (CVD) including heart attack and stroke.

Despite recent advances in clinical therapies, CVD remains the

leading cause of morbidity and mortality world-wide. Thus, there is a

need to discover the underlying mechanisms that lead to CVD. Inter-

cellular communication is essential for maintenance of blood vessel

homeostasis and disease development. Our laboratory is interested

in a new mechanism of cell-cell communication which involves

extracellular vesicles (EV). These vesicles carry unique cargo (lipids,

proteins, miRNAs and DNA) which can be transmitted to target cells

as well as serve as biomarkers which indicate the heath status of the

vasculature. Specific projects focus on 1) characterization of EVs in

vascular health and disease 2) functional effects of EVs in the

vasculature and 3) the potential for EVs to act as therapeutic agents

to treat CVD.

TUHSC Seeking

motivated

students

who desire

to gain

hands-on

experience

in basic

biomedical

research.

Biology,

Biochemist

y,

Chemistry ,

Bioenginee

ring

Steven

Houser

srhouser@t

emple.edu

LKSOM Cariology Role of Cortical

bone derived

stem cells for

improving heart

function after

myocardial

infarction

We are studying role of cortical bone derived stem cells (CBSCs) in

repair of heart after cardiac injury. We have previously shown that

these stem cells have capacity to improve heart function mainly by

secreting cardio protective factors and mediating cardiac repair by

differentiation into cardiac lineages. Currently, we are testing this

hypothesis in a larger animal model for clinical relevance of CBSCs.

Concurrently, we are focused on investigating if these beneficial

effects can be achieved by transfer of small vesicles called exosomes

from these cells.

TUHSC General lab

skills

Biology or

Chemistry

10/24/2019 11


Name

Email

Address

Faculty

School or

College

Faculty

Department


Location

Important

selection

criteria

Student

Majors

Desired

Minsun Lee tug35171@

temple.edu

LKSOM Center for

Asian Health

Addressing

Mental and

Brain Health

Problems in

Ethnic

Minorities

Ethnic minorities including Asian Americans experience significant

disparities in receiving mental health care despite thier existing

problems due to diverse barriers. This project is designed to examine

mental and brain helath realted problems and pattern of service use

among ethnic minority groups. Our goal is to develop intervention

strategies to enhance their service use to address the mental and

brain health related problems.

TUHSC Good writing

and data

analysis

skills; be

able to work

independent

ly and team

player,

motivated

and reliable.

Any fields,

experience

and/or

interests in

health and

social

science

preferred

Grace Ma grace.ma@

temple.edu

LKSOM Center for

Asian Health

& Clinical

Sciences

Cancer, CVDs,

Diabetes-Ethnic

populations

We have over 18 ongoing studies focusing on Cancer, CVDs, diabetes,

Hypertension and HIVin underserved ethnic minority popualtions to

reduce health disparities in clinical and community settings. Go to

"medicine.temple.edu/cah"

TUHSC Good writing

skills; be

able to work

independent

ly and team

player,

motivated

and reliable.

Any fields,

with health

science

interests

preferred

Hong Wang hongw@te

mple.edu

LKSOM Center for

Metabolic

Disease

Research

Biochemical

basis for HHcy-

induced

cardiovascular

Disease

To study how hyperhomocysteinemia (HHcy), a medical condition

characterized by an abnormally high level of homocysteine in the

blood, causes cardiovascular disease, the number one killer in the

United States and developed countries. HHcy is a potent and

independent risk factor for CVD. However, the underlying

mechanism is unknown and effective therapy is not available. We

are the leading laboratory in this field and the first to report that Hcy

selectively activates endothelial cell via hypo-methylation related

mechanism and will further explore the biochemical basis of cell type

and gene specific methylation in cell and mouse disease models.

TUHSC Motivation,

carefulness -

Students

who

completed

sophomore

year.

Biology

10/24/2019 12


Name

Email

Address

Faculty

School or

College

Faculty

Department


Location

Important

selection

criteria

Student

Majors

Desired

Hong Wang hongw@te

mple.edu

LKSOM Center for

Metabolic

Disease

Research

Metabolic

disorder-

induced

immune cell

differentiation

We have extensive expertise in the areas of cardiovascular

inflammation, atherosclerosis, vascular function, molecular

mechanism, and signal transduction. UPR studies will use

bioinformatics, cell biology and molecular biochemical approaches to

assess the potential mechanisms metabolic disorder-induced

immune cell differentiation. We will examine monocyte

differentiation, vascular and systemic inflammation, and vascular cell

growth control and apoptosis. Each UPR student will be instructed by

a PhD student or a postdoctoral fellow.

TUHSC GPA greater

than 3.4,

Cell culture

or Protein

biochemistry

, Hard

working and

dedicative

Biology,

Biochemistr

y,

Computer

Science

Wenhui Hu whu@temp

le.edu

LKSOM Center for

Metabolic

Disease

Research,

Department

of Pathology

and Lab Med

Molecular

mechanisms of

hypothalamic

neurogenesis

and neural

metabolic

syndrome

The research interest in Dr. Hu’s lab focuses on the role and

mechanisms of a novel protein NIBP, which regulates NFkB signaling

and trans-Golgi networking. Mutation of NIBP contributes to mental

retardation, autism, obesity and stroke. In particular, NIBP knockout

mice develop obesity under normal diet. Also, the lab is interested in

the novel role of the schizophrenia and autism spectrum disorder

gene TCF4 in regulating neuritogenesis and synaptic plasticity. The

qualified students will actively participate in the daily research

activities in the laboratory. These activities include: neural stem cell

culture, transfection, reporter gene assay, CRISPR/Cas9 genome

editing, molecular cloning, RT-PCR, Western blot,

immunohistochemistry, confocal imaging, genotyping and

phenotyping. The students will also participate in the weekly journal

club and weekly seminar in the department. The students are

expected to understand the research publications by Dr. Hu’s group

as well as the current progresses in the field of neural metabolic

diseases, adult neurogenesis and genome editing. The students with

previous research background will be given a small research project

that potentially generates publishable data.

TUHSC Motivation

for science,

responsible

and reliable

Neuroscien

ce, Biology,

Psychiatry,

Bioenginee

ring,

Computer

science

10/24/2019 13


Name

Email

Address

Faculty

School or

College

Faculty

Department


Location

Important

selection

criteria

Student

Majors

Desired

Wenhui Hu whu@temp

le.edu

LKSOM Center for

Metabolic

Disease

Research,

Department

of Pathology

and Lab Med

Molecular

mechanisms of

hypothalamic

neurogenesis

and neural

metabolic

syndrome

The research interest in Dr. Hu’s lab focuses on the role and

mechanisms of a novel protein NIBP, which regulates NFkB signaling

and trans-Golgi networking. Mutation of NIBP contributes to mental

retardation, autism, obesity and stroke. In particular, NIBP knockout

mice develop obesity under normal diet. Also, the lab is interested in

the novel role of the schizophrenia and autism spectrum disorder

gene TCF4 in regulating neuritogenesis and synaptic plasticity. The

qualified students will actively participate in the daily research

activities in the laboratory. These activities include: neural stem cell

culture, transfection, reporter gene assay, CRISPR/Cas9 genome

editing, molecular cloning, RT-PCR, Western blot,

immunohistochemistry, confocal imaging, genotyping and

phenotyping. The students will also participate in the weekly journal

club and weekly seminar in the department. The students are

expected to understand the research publications by Dr. Hu’s group

as well as the current progresses in the field of neural metabolic

diseases, adult neurogenesis and genome editing. The students with

previous research background will be given a small research project

that potentially generates publishable data.

TUHSC Motivation

for science,

responsible

and reliable

Neuroscien

ce, Biology,

Psychiatry,

Bioenginee

ring,

Computer

science

Lee-Yuan

Liu-Chen

lliuche@te

mple.edu

LKSOM Center for

Substance

Abuse

Research

Kappa opioid

receptor (KOR):

pharmacology,

neuroanatomy

and behaviors

1. genotyping and biochemical and behavior characterization of

mutant mouse lines, including phosphorylation-deficient KOR mutant

mice, b-arr2 knockout mice and KOR-tdTomato mice 2. Screening for

selective KOR agonists that produce analgesic and anti-itch effects,

but do not cause side effects such as aversion, sedation and motor

incoordation

TUHSC solid grades,

eager to

learn,

organized,

some lab

experience

preferred

Neuroscien

ce,

Biochemistr

y

10/24/2019 14


Name

Email

Address

Faculty

School or

College

Faculty

Department


Location

Important

selection

criteria

Student

Majors

Desired

Lee-Yuan

Liu-Chen

lliuche@te

mple.edu

LKSOM Center for

Substance

Abuse

Research

&

Department

of

Pharmacology

Characterizatio

n of a knockin

mouse line

expressing a

fusion protein

of the kappa

opioid receptor

(KOPR) and the

fluorescent

protein

tdTomato (tdT)

[KOPr-tdT]

Lack of specific antibodies against the KOPR has hindered in vivo

study of KOPR in terms of localization, trafficking, expression and

signaling. My lab has generated a knockin mouse line expressing

KOPR-tdT. The project is to do genotyping of the mice and map the

distribution of KOPR-tdT in the brain.

TUHSC solid grades,

eagerness to

learn,

organized,

some lab

experience

preferred,

experience

in handling

rodents,

perfusion

and tissue

Neuroscien

ce

Douglas

Tilley

douglas.till

ey@temple

.edu

LKSOM Center for

Translational

Medicine

Leukocytes and

Cardiorenal

Syndrome

Cardiorenal syndrome (CRS) is a growing clinical problem that

substantially increases the risk of adverse cardiovascular events and

mortality outcomes in patients and costs billions of dollars per year

in the U.S. Approximately 50% of CRS cases result from a

deterioration in cardiac function, such as during the development of

heart failure (HF), which promotes renal fibrotic remodeling and

progressive dysfunction. A number of factors contribute to the

development of CRS, including changes in hemodynamics, humoral

factors such as cytokines and sympathetic nervous system (SNS)

activation. Responsive to each of these changes are leukocytes,

particularly monocytes and macrophages, which have been

implicated in CRS. However, few reports have investigated whether

they play a reactionary or causative role in the development of CRS-

induced renal dysfunction and remodeling or how to mitigate their

impact in this process. Since renal dysfunction remains a strong

independent predictor for poor prognosis in CVD patients, targeting

leukocytes to prevent the development of renal dysfunction and

remodeling in response to cardiac stress may offer a new strategy by

which to alleviate the negative impact of CRS on patient mortality.

For this project the URP student will perform a comparative

TUHSC biochemistr

y,

chemistry,

biology

10/24/2019 15


Name

Email

Address

Faculty

School or

College

Faculty

Department


Location

Important

selection

criteria

Student

Majors

Desired

John Elrod elrod@tem

ple.edu

LKSOM Center for

Translational

Medicine

Identification of

novel sORFs in

cardiovascular

disease

elrodlab.org

It has recently become apparent that previous computational

methods used to identify genes throughout the human genome likely

missed a significant number of small genes (small open reading

frames, sORFs) that encode micropeptides that likely play a very

significant role in physiology and disease. The overall goal of this

project is to discover new genes with novel functions and regulatory

roles in cardiovascular disease. We have begun to establish a

database containing all possible sORFs in the genome to prioritize

our search for bona fide peptide encoding sORFs. In addition, we

examining the differential expression of sORFs in disease starting

with heart failure samples from two well characterized, clinically

relevant mouse models. All of these data will be computationally

integrated to generate a priority list for experimental validation and

evaluation.

TUHSC Priority

placed on

previously

molecular

biology

laboratory

experience.

Motivated,

hard-

working

individuals

are a must.

Any

Mohsin

Khan

tuf72052@

temple.edu

LKSOM Center for

Translational

Medicine

Human Cardiac

stem cell and

exosome based

therapies for

cardiac

regeneration

The goal of these studies is to develop a cardiac regeneration

strategy based on human cardiac stem cells isolated from heart

failure patients. Understanding the role of aging and disease onset

will allow development of novel strategies for enhancing human

cardiac stem ability to repair the heart after myocardial damage.

Students will work with characterizing human cardiac stem cells by

fluorescence microscopy, immunoblot analysis, viral modification

and cell proliferation/death assays. Students will be expected to

work on these projects efficiently with inclusion of their name in a

conference abstract or a publication depending on the level of their

contribution.

TUHSC General Lab

Skills

Biology

Sara Jane

Ward

saraward@

temple.edu

LKSOM CSAR Cannabinoids,

Inflammation,

and CNS Injury

Research focuses on determining the role of inflammation across a

range of CNS disorders, from stroke to substance abuse. We take a

behavioral and molecular immunological approach to studying the

role of inflammation in CNS disorders and testing the hypothesis that

cannabinoid based-treatments have a potential to reduce this

inflammation and therefore improve behavioral outcomes.

TUHSC Interest in

neuroscienc

e/experimen

tal

psychology

Neuroscien

ce,

Psychology

10/24/2019 16


Name

Email

Address

Faculty

School or

College

Faculty

Department


Location

Important

selection

criteria

Student

Majors

Desired

John Elrod elrod@tem

ple.edu

LKSOM CTM Mitochondrial

Calcium

Exchange in

Heart Disease

Summer Research Students would be assisting lab members with

general tasks ranging from mouse colony maintenance, genotyping,

histology, cell culture and various other experiments that are needed

for our current projects. You can view our recent publications and

current projects via our website. Link listed below.

http://www.elrodlab.org/projects/#/lab-publications/

TUHSC Agreeablene

ss and

willingness

to learn.

Biology

Sadia

Mohsin

tuf65474@

temple.edu

LKSOM CVRC Stem cells to

repair heart

after injury

The project would help in understanding different mechanisms that

could be involved in heart repair after stem cell or exosomes

transplantation after cardiac injury. Immune response is one of the

major events that occur after injury. We would study how stem cells

can play a part in modulating immune response after myocardial

infarction.

TUHSC Biology or

BioChem

Sadia

Mohsin

tuf65474@

temple.edu

LKSOM CVRC Cardiac repair

after ischemic

injury

The project would help in understanding different mechanisms that

could be involved in heart repair after stem cell or exosomes

transplantation after cardiac injury. Immune response is one of the

major events that occur after injury. We would study how stem cells

can play a part in modulating immune response after myocardial

infarction.

We will also study interaction of stem cells and other heart cell types

including fibroblasts and myocytes.

TUHSC Biochem or

Biology

10/24/2019 17


Name

Email

Address

Faculty

School or

College

Faculty

Department


Location

Important

selection

criteria

Student

Majors

Desired

Mahmut

Safak

msafak@te

mple.edu

LKSOM Department

of

Neuroscience

Understanding

the regulatory

roles of JC virus

agnoprotein in

viral life cycle

JC virus is a human polyomavirus that causes a fatal disease, known

as progressive multifocal leukoencephalopathy, in the central

nervous system of a sub-population of immunocompromised

individuals including AIDS and cancer patients. This virus encodes a

small regulatory protein, Agnoprotein, from its late coding region. In

the absence of its expression, this virus unable to sustain its

productive life cycle. It is a highly basic phosphoprotein that localizes

mostly to the perinuclear area of infected cells, although a small

amount of the protein is also found in nucleus. It forms highly stable

dimers/oligomers in vitro and in vivo through its Leu/Ile/Phe-rich

domain. Structural NMR studies revealed that this domain adopts an

alpha-helix conformation and plays a critical role in the stability of

the protein. It associates with cellular proteins, including YB-1, p53,

Ku70, FEZ1, HP1α, PP2A, and AP-3; and viral proteins, including small

t antigen, large T antigen, HIV Tat, and JCV VP1; and significantly

contributes the viral transcription and replication. Although much

has been learned about the function of this important protein in

recent years, its precise role in the viral life cycle remains elusive. Our

most recent studies showed that it targets mitochondria and

negatively regulates ATP production. It binds to viral RNA and CRM-1;

TUHSC Biology,

Chemistry,

Biochemistr

y,

Neuroscien

ce

Mahmut

Safak

msafak@te

mple.edu

LKSOM Department

of

Neuroscience

Investigation of

the regulatory

roles of JC virus

Agnoprotein in

viral life cycle

Agnoprotein is one of the important regulatory proteins of the

human polyomavirus, JC virus. It is a relatively small and basic

protein. we have recently demonstrated that it forms highly stable

dimers and oligomers. It exhibits the ability to be released from the

infected cells. The implications of this release unknown. It appears to

bind to viral transcripts and ins involved in the splicing and nucleo-

cytoplasmic transport of these transcripts. Three dimensional

structure of this protein has been recently resolved by our lab,

confirming the involvement of dimerization domain in alpha-helix

formation. Our lab has been heavily involved in characterization of

the regulatory roles of this protein in viral life cycle in the past and

we will to do so for the next five year. This project has been recently

funded by NIH and therefore there are ample opportunities for any

prospective student to do research and understand the molecular

mechanisms of action of this protein in JC virus life cycle.

TUHSC Student with

a good work

ethics

Biology,

Chemistry

Biochemistr

y

Neuroscien

ce

10/24/2019 18


Name

Email

Address

Faculty

School or

College

Faculty

Department


Location

Important

selection

criteria

Student

Majors

Desired

Wenhui Hu whu@temp

le.edu

LKSOM Department

of Pathology

and Lab Med

Target-specific

delivery of

CRISPR/Cas9

genome editors

to Disease-

relevant cells

CRIPSR/Cas9 genome editing has been drawing extensive attention in

both science and public. It has revitalized the gene and cell therapy.

A large number of exciting and promising preclinical studies escalate

the potential of genome editors to treat patients with genetic

diseases, infectious diseases, cancer and others. One of many

challenges before wide clinical application is the urgent need to

effectively, specifically and safely deliver the powerful genome

editing machinery to disease-relevant cells and tissues. Dr. Hu’s lab is

interested in developing novel viral and non-viral gene delivery for

Cas9/sgRNA-expressing vectors or ribonucleoprotein by targeting

neural, immune and cancer cells. The qualified students will actively

participate in the daily research activities in the laboratory. These

activities include: molecular cloning, PCR genotyping, real-time PCR,

genome editing evaluation, cell culture, transfection, reporter gene

assay, Western blot, immunohistochemistry, confocal imaging, etc.

The students are expected to understand the research publications

by Dr. Hu’s group as well as the current progresses in the field of

genome editing and gene/cell therapy. The students with previous

research background will be given a small research project that

potentially generates publishable data.

TUHSC High

motivation

for science,

responsible

and reliable,

hard-

working

Molecular

biology,

Genetics,

Biology,

Neuroscien

ce

Beata

Kosmider

tug28074@

temple.edu

LKSOM Department

of Thoracic

Medicine and

Surgery

Mutation

analysis in

emphysema.

Two million Americans suffer from chronic obstructive pulmonary

disease, costing $2.5 billion/year and contributing to 100,000

deaths/year. Emphysema is caused by the destruction of alveolar

wall septa, which is associated with inflammation. Alveolar type II

cells make and secrete pulmonary surfactant and restore the

epithelium after damage. In our preliminary data we identified 6

mutations in genomic DNA obtained from alveolar type II cells

isolated from patients with emphysema. Our hypothesis is that these

mutations may contribute to this disease pathogenesis.

Student task and responsibility: The student will first get training in

general laboratory techniques. This person will be involved in

planning experiments with a research group, preparing samples for

DNA isolation and analyze sequencing results. We will meet at least

once every week to discuss this project. The student will validate the

functional role of these novel identified mutations in A549 cell line

and human primary alveolar type II cells in vitro.

Two million Americans suffer from chronic obstructive pulmonary

TUHSC Biology or

Biochem

10/24/2019 19


Name

Email

Address

Faculty

School or

College

Faculty

Department


Location

Important

selection

criteria

Student

Majors

Desired

Beata

Kosmider

tug28074@

temple.edu

LKSOM Department

of Thoracic

Medicine and

Surgery

The role of

microvesicles in

emphysema.

Microvesicles are small membrane vesicles of 30–1,000 nm in

diameter that are released into the extracellular environment under

normal or pathological conditions by different types of cells including

alveolar type II cells. Our hypothesis is that microvesicles secreted in

emphysema may contain inflammatory factors, which can induce

injury of neighboring cells. In our preliminary data, we found higher

microvesicles secretion in alveolar type II cells isolated from patients

with this disease compared to control non-smokers and smokers. We

have also identified dysregulated expression of genes involved in

microvesicles synthesis by RNA sequencing in alveolar type II cells

isolated from patients with emphysema.

Student task and responsibility: The student will first get training in

general laboratory techniques. This person will be involved in

determining the role and mechanism of microvesicles secretion in

emphysema. The student will be responsible to determine

inflammatory response in control alveolar type II cells induced by

microvesicles secreted in emphysema in vitro. Methods include

standard molecular and cellular biology such as western blotting,

immunocytofluorescence and ELISA.

Microvesicles are small membrane vesicles of 30–1,000 nm in

TUHSC Biology or

Biochem

Tasuku

Akiyama

tasuku.akiy

ama@temp

le.edu

LKSOM Dermatology

and Anatomy

& Cell Biology

Brain

Processing of

Itch

TUHSC

Jonathan

Soboloff

soboloff@t

emple.edu

LKSOM Fels Cancer

Research

Role of STIM-

dependent

calcium signals

in T cell

differentiation

T cells are critical players in adaptive immunity. T cells are made in

the thymus and then released into peripheral blood where they seek

out foreign agents. One of the first events that occurs in T cells when

activated is a change in cytosolic calcium concentration. These

calcium responses drive their differentiation into multiple

differentiated T cell subsets that control the immune response in a

manner dependent on both the duration and intensity of the calcium

signal. We utilize a combination of cell lines and mouse models to

TUHSC Student

must be

enthusiastic

with a

genuine

interest in

learning

research.

Biology/Bio

chemistry

10/24/2019 20


Name

Email

Address

Faculty

School or

College

Faculty

Department


Location

Important

selection

criteria

Student

Majors

Desired

Kelly

Whelan

kelly.whela

n@temple.

edu

LKSOM Fels Institute Role of

STIM/Orai in

esophogeal

differentiation

and

carcinogenesis

Role of STIM/Orai in esophogeal differentiation and carcinogenesis Fels

Institute

for

Cancer

Research

Student

must be

enthusiastic

with a

genuine

interest in

learning

research.

Prior lab

experience

would be

highly

desirable

but not

required.

Project

involves cell

Biology/Bio

chemistry

Italo

Tempera

tempera@t

emple.edu

LKSOM Fels Institute

for Cancer

Research

Post-

translation

modifications of

LMP1

LMP1 is an important viral protein that is expressed by Epstein-Barr

virus, EBV, during latent infection. EBV is a human herpesvirus that

infects B cells and establishes a persistent infection in 95% of the

population worldwide. LMP1 plays an essential role in activating B

cells and inducing cell proliferation. Targeting LMP1 is an important

strategy that the host employs to counteract EBV infection. For

example, cellular transcriptional repressors can bind the LMP1

promoter and block the expression of this viral protein. However

other mechanisms can also control LMP1. We recently found that the

cellular protein PARP1 can modify LMP1. PARP1 catalyzes the post-

translational polymerization of ADP-ribose on target proteins, in a

reaction called poly(ADP-ribosyl)ation, or PARylation. The

incorporation of these long, negatively charged polymers of ADP-

ribose alters the function of target proteins. Thus, we want to

determine the effect of PARylation on LMP1 functions. The aims of

the proposed project are: 1) to map the PARylation site of LMP1 by

generating different LMP1 constructs and perform in vitro

PARylation; 2) to transfect these LMP1 constructs in 293 cells and

assess if they can be PARylated; 3) to generate LMP1-PAR-null

mutants and study their effects on cell proliferation and cell

transformation.

Fels

Institute

for

Cancer

Research

Must have

completed

Biol 1111

Biology or

Biochem

10/24/2019 21


Name

Email

Address

Faculty

School or

College

Faculty

Department


Location

Important

selection

criteria

Student

Majors

Desired

Jonathan

Soboloff

soboloff@t

emple.edu


for Cancer

Research

UV-Induced

Suppression of

calcium

signaling in

Melanoma

Metastatic

Progression

Increases in cytosolic Ca2+ concentration are a common component

of multiple signal transduction pathways regulating a wide variety of

responses ranging from rapid events such as membrane fusion and

muscle contraction to control of proliferation, differentiation and

apoptosis. STIM proteins sense changes in ER Ca2+ levels; when ER

Ca2+ levels are low, STIM proteins bind to Orai Ca2+ channels that

promote Store-Operated Calcium Entry (SOCE). Ultraviolet radiation

is a major cause of melanoma and has been linked to melanoma

progression. Among other things, UVR causes suppression of Ca2+

signals that we believe contributes to increases in melanoma

invasiveness. Working closely with a graduate student, a technician

and other undergraduate students in my lab, this project will involve

measuring calcium signals, performing fluorescence microscopy and

various cellular assays in melanoma cell lines.

Fels

Institute

for

Cancer

Research

Student

must be

enthusiastic

with a

genuine

interest in

learning

research.

Prior lab

experience

would be

highly

desirable

but not

required.

Project

involves cell

Biology/Bio

chemistry

Jonathan

Soboloff

soboloff@t

emple.edu


for Cancer

Research

Modulation of

calcium

signaling by

changes in STIM

expression

Increases in cytosolic Ca2+ concentration are a common component

of multiple signal transduction pathways regulating a wide variety of

responses ranging from rapid events such as membrane fusion and

muscle contraction to control of proliferation, differentiation and

apoptosis. Since Ca2+ signals typically occur in a time frame of

seconds to minutes, how Ca2+ transients can regulate events that

occur over hours to days is poorly understood. Recent investigations

from our lab have led to the identification of Early Growth Response

1 (EGR1) as a regulator of the expression of STIM1, a required

component of store-operated Ca2+ entry, the primary means of Ca2+

entry in non-excitable cells. A student working in my lab will

investigate how the expression and function of STIM1 and EGR1 are

coordinated in the context of receptor-mediated signals.

Fels

Institute

for

Cancer

Research

Student

must be

enthusiastic

with a

genuine

interest in

learning

research.

Prior lab

experience

would be

highly

desirable

but not

required.

Project

involves cell

Biology/Bio

chemistry

Nora Engel noraengel

@temple.e

du


for Cancer

Research

Genetics and

Epigenetics of

sex-specific

expression

patterns in

We are investigating differences between male and female

embryonic stem cells and the mechanisms by which these early

differences are established. Epigenetic assays will be performed to

detect the impact of sex on differentiation of the cells.

Fels

Institute

for

Cancer

Research

Basic

laboratory

skills, such

as pipetting

and making

Biology,

Biochemistr

y

10/24/2019 22


Name

Email

Address

Faculty

School or

College

Faculty

Department


Location

Important

selection

criteria

Student

Majors

Desired

Raza Zaidi zaidi@tem

ple.edu


for Cancer

Research

molecular

mechanisms of

Melanomagene

sis

Melanoma is the deadliest type of skin cancer, which originates from

the pigment (melanin)-producing cells (melanocytes) in the skin.

Approximately 85% of melanomas are directly caused by the UV

radiation from the sun and artificial tanning beds. However, the

molecular mechanisms of this cause-and-effect relationship remain

largely undefined. We are using cell culture and mouse models, and

cutting-edge molecular biological techniques, genomics, and

epigenomics to tease out the molecular mechanisms of UV-induced

melanomagenesis.

Fels

Institute

for

Cancer

Research

Highly

motivated

individuals

who have

the passion

for

molecular

biology

research,

and are

willing to

commit

themselves

to a steep

learning

curve,

dedication,

Biochemisr

y or Biology

Raza Zaidi zaidi@tem

ple.edu


for Cancer

Research

molecular

mechanisms of

Melanomagene

sis

Melanoma is the deadliest type of skin cancer, which originates from

the pigment (melanin)-producing cells (melanocytes) in the skin.

Approximately 85% of melanomas are directly caused by the UV

radiation from the sun and artificial tanning beds. However, the

molecular mechanisms of this cause-and-effect relationship remain

largely undefined. We are using cell culture and mouse models, and

cutting-edge molecular biological techniques, genomics, and

epigenomics to tease out the molecular mechanisms of UV-induced

melanomagenesis.

Fels

Institute

for

Cancer

Research

Highly

motivated

individuals

who have

the passion

for

molecular

biology

research,

and are

willing to

commit

themselves

to a steep

learning

curve,

dedication,

Biochemisr

y or Biology

Richard

Pomerantz

richard.po

merantz@t

emple.edu


for Cancer

Research

Development of

Drugs for

BReast and

Ovarian Cancer

Patients

DNA Polymerase Theta (Polq) is essential for the proliferation of

subsets of breast and ovarian cancers, but is dispensable for normal

cell growth. Thus Polq is considered an important new cancer drug

target. We are screening and identifying drug-like inhibitors of Polq

that will be further developed as anti-cancer drugs.

TUHSC Interest in

biochemistry

and/or

cancer

therapeutics

.

Biology,Che

mistry,Pre-

medical

10/24/2019 23


Name

Email

Address

Faculty

School or

College

Faculty

Department


Location

Important

selection

criteria

Student

Majors

Desired

Richard T.

Pomerantz

richard.po

merantz@t

emple.edu


for Cancer

Research

How the

process of

transcription

contributes to

genome

instability in

human cells.

Genome instability in the form of chromosome breaks,

rearrangements and deletions is a hallmark of cancer cells and

contributes to tumorigenesis. The research project aims to

understand how the process of transcription contributes to genome

instability in human cells. Current research in the lab reveals a direct

link between transcription and DNA deletions and rearrangements in

human cancer cells. This suggests that transcription plays a much

larger role in promoting genome instability and potentially cancer

than previously thought. The goal of the project is to analyze and

annotate the sequences of DNA deletions and rearrangements

generated at transcription sites in human cells. The results of this

research is likely to provide new important insight into how the

fundamental process of transcription can cause genome instability

and will likely be published in a high profile journal.

TUHSC Intelligent,

hard-

working,

independent

, passionate

about

science and

research. -

General

Biology,

perhaps

Chemistry --

Successful

summer

research is

likely to be

published in

Biochemistr

y, Biology,

or

Chemistry

Richard T.

Pomerantz

richard.po

merantz@t

emple.edu


for Cancer

Research

This research

will provide

important

insight into how

polymerase

theta functions

during alt-EJ

and promotes

the survival of

cancer cells and

chemotherapy

resistance and

will likely be

published in a

A newly discovered DNA repair process called alternative end-joining

(alt-EJ) or microhomlogy-mediated end-joining causes chromosome

deletions and rearrangements and promotes the survival of breast

and ovarian cancer cells. Current research in the lab has

reconstituted the process of alt-EJ in vitro and has elucidated how a

key protein in this pathway, DNA polymerase theta, generates

insertion mutations at DNA repair junctions. The goal of the project is

to analyze and annotate the sequences of insertion mutations

generated by polymerase theta during alt-EJ in vitro. This research

will provide important insight into how polymerase theta functions

during alt-EJ and promotes the survival of cancer cells and

chemotherapy resistance and will likely be published in a reputable

journal.

TUHSC Intelligent,

hard-

working,

independent

, passionate

about

science and

research. -

General

Biology,

perhaps

Chemistry --

Successful

summer

Biochemistr

y, Biology,

or

Chemistry

10/24/2019 24


Name

Email

Address

Faculty

School or

College

Faculty

Department


Location

Important

selection

criteria

Student

Majors

Desired

Xavier

Grana

xgrana@te

mple.edu


for Cancer

Research

Understanding

Substrate

Specificity of

Protein

Phosphatases

and their

regulation in

normal and

cancer cells

There are various projects available that deal with the

characterization of the substrate specificity of the B55α/PP2A

holoenzyme and its regulation in cells. (1) B55α/PP2A holoenzyme

substrate specificity This project focuses on determining the

determinants of substrate specificity of B55α/PP2A holoenzymes

using various unrelated substrates of this holoenzyme. We have and

extensive collection of B55α mutants (>20 mutants) and more to be

made to be tested for binding to various substrates using transient

co-transfections made in human cells grown in culture. The project

involves cell culture, transfections, immunoprecipitation, western

blot analysis and generation and maintenance of plasmids. (2) To

identify the domains in p107 recognized by protein phosphatases.

This project is centered on determining the amino acid residues that

mediate the interaction of p107 with the PP2A. We have an

extensive collection of GST-p107 mutants to characterize this

interaction. More mutants will be generated based on

bioinformatics docking analysis and the results of binding assays. The

project involves cell culture, GST pull-down assays, western blot

analysis and generation and maintenance of plasmids. (3) Kinetics

of activation of RAF1 and of p107 following fibroblast growth factor

stimulation. This project is centered on understanding the kinetics of

activation of RAF1 and KSR1 in the MAPK pathway and activation of

p107 following growth factor stimulation by PP2A in chondrocytes.

The project involves co-transfections with various expression

constructs to determine the complexes that form in two human cell

lines prior to attempting the same in chondrocytes that are more

technically challenging. The project involves cell culture,

transfections, immunoprecipitation, western blot analysis and

generation and maintenance of plasmids. It may also involve

immunofluorescence microscopy. Our previous references relevant

to the proposed work: 1. Kurimchak A, Haines DS, Garriga J, Wu S,

TUHSC Motivation

for Science

and

Research

Background

knowledge -

Previous lab

experience is

NOT

required

Biochemistr

y, Biology,

Bioinforma

tics -

Genetics

and/or

Biochemistr

y and/or

Cell Biology

10/24/2019 25


Name

Email

Address

Faculty

School or

College

Faculty

Department


Location

Important

selection

criteria

Student

Majors

Desired

Xavier

Graña

xgrana@te

mple.edu


for Cancer

Research

Protein

phosphatase 2A

in cancer and

the control of

cellular

processes

Project 1: While it is well accepted that PP2A plays a key tumor

suppressor function in human cells, the particular holoenzyme(s)

implicated in different tumor types is unclear at best. PP2A is a major

Ser/Thr Protein Phosphatase that functions as a trimeric holoenzyme

consisting of a scaffold protein (A), which bridges a catalytic subunit

(C) and a regulatory B subunit. The regulatory subunit is thought to

mediate substrate specificity and integrate regulatory inputs from a

variety of signaling pathways. There are four different families of B

regulatory subunits (B, B’, B’’ and B’’’), each with multiple members

encoded by distinct genes. We have found, that limited ectopic

expression of subunits of PP2A in cancer cell lines that naturally

express lower levels than normal cells and other cancer cell lines

results in dramatic toxicity. We have linked this to G2/M arrest,

without concomitant loss in DNA replication, which leads to

euploidy, nuclear enlargement and a subsequent block in

proliferation and cell death. Thus, early hemizygous loss of certain

PP2A B subunits may facilitate effective mitotic progression. We have

TUHSC - No

previous

expertise

needed. -

Strong

interest in

pursuing a

research

related

career -

Students

who have

taken Cell

structure

and

Function,

Genetics,

Biology,

Biochemistr

y

Laurie

Kilpatrick,

PhD

laurie.kilpat

rick@templ

e.edu

LKSOM Lung

Center/Physio

logy

Regulation of

neutrophil-

endothelial

interactions in

bacterial sepsis

Dr. Kilpatrick’s research focuses on investigating molecular

mechanisms regulating pro-inflammatory signaling in the innate

immune system; particularly the role of activated leukocytes in the

development of lung injury. An important focus of her work is

examining the regulation of leukocyte migration into the lung. Using

both in vitro and in vivo approaches, she is examining signaling

pathways which regulate leukocyte-endothelial interaction and the

control of transmigration. Her research group has extensive expertise

with different models of inflammation in rodents and in the isolation

and analysis of human neutrophils, monocytes and alveolar

macrophages. Dr. Kilpatrick identified Protein Kinase C-delta (PKCδ)

as a critical regulator of the inflammatory response in the lung. In

translational studies, she is studying the use of directed anti-PKCδ

therapy to the lung for the treatment of acute lung injury in a rodent

model of sepsis employing pharmacological (PKCδ inhibitor) and

TUHSC Some

previous lab

experience,

highly

motivated

with an

interest in

research

Biochemistr

y,

Chemistry,

Biology

10/24/2019 26


Name

Email

Address

Faculty

School or

College

Faculty

Department


Location

Important

selection

criteria

Student

Majors

Desired

Brad

Rothberg

rothberg@t

emple.edu

LKSOM Medical

Genetics and

Molecular

Biochemistry

Crystal

structures of

potassium

channel

proteins

Potassium channels are membrane proteins that are critical for

electrical signaling in nerve and muscle cells. Our research is focused

on crystallizing potassium channel proteins and their regulatory

domains, with the goal of solving the structures of these proteins

using X-ray diffraction. Note: This is expected to be a training

experience, so previous experience in X-ray crystallography is not

required.

TUHSC Most

important

criterion is a

strong

interest in

protein

structure

and/or

neuroscienc

e. Previous

laboratory

experience is

preferred,

but NOT

required.

Good

communicati

Biology;

Biochemistr

y;

Chemistry;

Neuroscien

ce

Glenn S.

Gerhard

tuf81289@

temple.edu

LKSOM Medical

Genetics and

Molecular

Biochemistry

A new thyroid

cancer gene.

Cellular hydrogen peroxide is associated with cancer, although the

source(s) and precise role remains unclear. We have identified a

candidate cancer gene in a family with a highly penetrant dominant

form of papillary (non-medullary) thyroid cancer. A predicted

damaging mutation in a transmembrane domain segregated with

papillary thyroid cancer in the family. We hypothesize that the

transmembrane mutation causes mis-localization of the protein to

the cytoplasm with inappropriate intra-cellular production of

hydrogen peroxide that subsequently leads to the development of

papillary thyroid cancer in carriers of the mutation. Our aims are to

determine whether the mutation causes oxidative stress in vitro and

thyroid cancer in zebrafish and mice.

TUHSC Team

oriented

Prior

laboratory

experience

Science GPA -

-If you work

with

zebrafish, be

prepared to

get wet!

Biochemistr

y Biology

Chemistry

10/24/2019 27


Name

Email

Address

Faculty

School or

College

Faculty

Department


Location

Important

selection

criteria

Student

Majors

Desired

Parkson

Lee-Gau

Chong

pchong02

@temple.e

du

LKSOM Medical

Genetics and

Molecular

Biochemistry

Design of Novel

Liposomes for

Drug Delivery

The goal of this research is to design novel liposomes for targeted

drug delivery to treat cancers. We will use bipolar tetraether lipids

(BTL) as the matrix lipids and polyethylene glycol (PEG)-linked

conventional lipids as the minor component to make liposomes (100-

200 nm in diameter) with entrapped anticancer drugs. BTL will be

isolated from the thermoacidophilic archaea Sulfolobus

acidocaldarius. Physical properties of these BTL-based liposomes will

be characterized using a variety of biophysical techniques. Drug

release and the inhibitory effect of liposomal drug against breast

cancer cells will be monitored. These BTL-based liposomes are

expected to show remarkable stability against temperature, pH

gradient, mechanical stress, pressure, serum proteins, bile salts, and

enzymatic digestions; and, they can be tailored for targeted delivery

and controllable release of anticancer drugs to solid tumors. This

multidisciplinary research involves microbe growth, lipid purification,

chemical modification and characterization of archaeal lipids,

fluorescence spectroscopy, microscopy, calorimetry, and the usage

of cell biology techniques. The obtained results may lead to new

designs of liposomal drugs to treat cancers with a higher efficacy.

TUHSC GPA,

research

interest -

Basic chem.

lab skills

Chemistry,

Biology,

and Physics

Parkson

Lee-Gau

Chong

pchong02

@temple.e

du

LKSOM Medical

Genetics and

Molecular

Biochemistry

Novel

Membranes for

Targeted Drug

Delivery/Contro

lled Release and

Other

Technological

Applications

Such As

Artificial

Photosynthesis

Project 1: Archaeal bipolar tetraether liposomes (BTL) are

remarkably stable and robust biomaterials, holding great promise for

technological applications. They can be used as targeted carriers,

slow-release drug carriers, biosensors, microbubbles for imaging and

diagnosis, sterilized storage devices, and coating materials. The goals

of this research are: (1) to gain a deeper molecular understanding of

the structure-activity relationship of BTL liposomes in order to

improve their usage as biomaterials and explore their possible new

applications, and (2) to design and fabricate liposomes (i) for

targeting phosphatidylserine- and phosphatidylethanolamine-rich

areas in cells and (ii) as thermosensitive liposomes for controlled

drug release. Project 2: The main objective of this research is to

fabricate a highly efficient and durable, membrane-based artificial

photosynthesis device using novel lipids and enzymes from

thermoacidophiles. The system would be capable of converting

sunlight, CO2 and water into carbohydrates for the production of

biofuels such as ethanol. The innovation of this research lies in (i) the

TUHSC having

passion in

science and

technology;

eager to

learn new

things;

willing to

devote a

significant

amount of

time to the

lab work; -

general

chemistry--

required;

advanced

Chemistry,

Biology,

Physics,

Bioenginee

ring

10/24/2019 28


Name

Email

Address

Faculty

School or

College

Faculty

Department


Location

Important

selection

criteria

Student

Majors

Desired

Ling Yang ling.yang@

temple.edu

LKSOM Medical

Genetics and

Molecular

Biology

Identification of

novel

therapeutic

approaches to

treat metabolic

disorders

Our current research interests are 1) long non-coding RNAs (lncRNAs)

and protein-coding genes in metabolic disorders; 2) RNA or RNA

targeted therapies to treat metabolic disorders; and 3) Multi-Omics

approach to dissect the pathological process of metabolic disorders.

Students will get exposure to both bioinformatics and experimental

biology.

TUHSC Interested in

metabolic

diseases.

Self-

motivated

and detail-

oriented.

Knowledge

of general

molecular

Biology,

Biochemistr

y,

Computer

science,

Mathmatic

s, or

related

majors

Mohan

Patnala

Achary

achary@te

mple.edu

LKSOM Metastasis

and Radiation

Research Lab

Markers for

non-metastatic

human breast

cancers and

inhibition of

human

glioblastoma In

Vivo.

Validation of genomic and gene expression markers for

differentiating human metastatic and non-metastatic primary breast

cancers. Inhibition of human glioblastoma tumors by betulinic acid

combined with ionizing radiation in a nude mouse model.

TUHSC None to one

summer lab

research

experience -

Sincerity

Biology

Tomasz

Skorski

tskorski@t

emple.edu

LKSOM Microbbiolog

y and

Immunology,

Fels Cancer

Research

Personalized

medicine-

guided

synthetic

lethality to

eradicate tumor

cells

Leukemia stem cells (LSCs), and especially quiescent LSCs, have a

dual role as tumor initiating and therapy-refractory cells. Currently

available anti-tumor treatments clear a disease burden consisting

mostly of leukemia progenitor cells (LPCs), but they usually fail to

eradicate drug-refractory quiescent LSCs and drug-resistant

proliferating LSCs/LPCs. Altered DNA repair mechanisms were

suggested to be responsible for stimulation of survival of LSCs and/or

LPCs under genotoxic stress.

DNA double-strand breaks (DSBs), the most lethal DNA lesions, are

repaired by two major mechanisms, homologous recombination (HR)

and non-homologous end-joining (NHEJ). BRCA -mediated HR (B-HR)

and DNA-PK –mediated NHEJ (D-NHEJ) repair DSBs in proliferating

cells and D-NHEJ plays a major role in quiescent cells. PARP1-

dependent NHEJ (P-NHEJ) and RAD52-dependent HR (R-HR) serve as

back-ups/alternative mechanisms in proliferating and/or quiescent

cells.

The existence of these pathways creates the opportunity to apply

“synthetic lethality” triggered by PARP1 and/or RAD52 inhibitors

(PARP1i and RAD52i, respectively) in DNA-PK –deficient therapy-

TUHSC biology

10/24/2019 29


Name

Email

Address

Faculty

School or

College

Faculty

Department


Location

Important

selection

criteria

Student

Majors

Desired

Marion

Chan

marionc@t

emple.edu

LKSOM Microbiology The action of

dietary

phytochemicals

on ovarian

cancer cells

Tumors constitute from heterogeneous cell populations. Within

them are a group of self renewing and differentiating stem cells,

named tumor initiating cells or cancer stem cells (CSCs). These CSCs

have been regarded as the cause of drug resistance and metastasis.

The goal of our project is to test whether certain dietary

phytochemicals (curcumin, EGCG, quercetin, resveratrol) and

pharmaceutical small molecules (metformin, niclosamide,

thioridazine) are effective in eliminating CSC population in ovarian

cancer. Students will learn sterile technique, pipetting accuracy,

tissue culture techniques, drug testing protocols and how to isolate

human ovarian CSCs from the cell lines A2780 and C200

TUHSC Good work

ethics,

punctual,

analytical

thinking,

dexterity

Biological

Sciences

related

majors and

Chemistry

majors -

Basic/Intro

ductory

Biology

Bettina

Buttaro

bbuttaro@

temple.edu

LKSOM Microbiology

and

Immunology

Enterococcal

pheromone

inducible

conjugative

plasmids as

virulence

factors and

disseminators

of antibiotic

resistance

genes

Pheromone inducible conjugative plasmids, such as pCF10, play a

central role in the ability of Enterococcal faecalis to cause disease.

They encode antibiotic resistance and virulence genes in addition to

mediating transfer of chromosomal determinants between strains.

These plasmids also contribute to the ability of the bacteria to cause

disease and to spread antibiotic resistance genes to other species

and genera of bacteria. The goal of the chemistry/biochemisty

projects is to characterize the molecular mechanisms that allow the

bacteria to vary the copy number of the plasmids in response to

oxidative stress. The goal of the biology projects is to understand

how the plasmid transfers antibiotic resistance genes to bacteria in

mixed species biofilms.

TUHSC desire to

learn to

design and

perform

experiments

independent

ly under

guidance --

Students are

given a

scientific

question to

answer

experimenta

lly. They will

be mentored

in designing

chemistry/

biochemistr

y and

biology

Bettina

Buttaro,

PhD

bbuttaro@

temple.edu

LKSOM Microbiology

and

Immunology

Antibiotic

Resistance

Gene Transfer

Mediated by

Enterococcus

faecalis plasmid

pCF10.

The plasmid makes helps make E. faecalis antibiotic resistant and

virulent. Current biochemistry projects focus on characterizing how

oxidative stress increases the number of plasmids in the bacterial

cell. The biology projects focus on how the plasmid transfers

antibiotic resistance genes to other bacteria in mixed species

biofilms.

TUHSC introductory

biology or

chemistry

courses are

sufficient

Chemistry

and Biology

10/24/2019 30


Name

Email

Address

Faculty

School or

College

Faculty

Department


Location

Important

selection

criteria

Student

Majors

Desired

Stefania

Gallucci

gallucci@te

mple.edu

LKSOM Microbiology-

Immunology

Regulation of

Type I

Interferons in

Autoimmunity

The project includes studies of cellular immunology and molecular

biology of signal transduction of cytokines involved in the

pathogenesis of an autoimmune disease, Systemic Lupus

Erythematosus. The goal of the project is to test novel biologics to be

used in the therapy of autoimmune diseases.

TUHSC Strong

motivation

to learn and

hard

working.

Biology_Pre

med

Bassel E

Sawaya

sawaya@te

mple.edu

LKSOM Neurology/Fel

s Institute

Can HIV-1

proteins

promote

premature

brain aging

Patients infected with HIV-1 suffer from learning and memory deficit.

The mechanisms leading to these alterations remain unknown. We

are in the process of deciphering these mechanisms

TUHSC Ask, Learn,

Enjoy, -

Serious,

ability to

learn and to

interact with

others 1-

Someone

who is

serious,

ready to

learn. If the

students

All

Ilker K

Sariyer

isariyer@te

mple.edu

LKSOM Neuroscience Neuroimmune

regulation of JC

virus gene

expression in

glial cells

Patients undergoing immune modulatory therapies for the treatment

of autoimmune diseases such as multiple sclerosis, and individuals

with an impaired-immune system, most notably AIDS patients, are in

the high risk group of developing progressive multifocal

leukoencephalopath (PML), a fatal demyelinating disease of the

white matter caused by human neurotropic polyomavirus, JC virus.

We employ multidisciplinary strategies to determine molecular

mechanism of JC virus reactivation during the latent period of viral

infection. JC virus replicates almost exclusively in glial cells, and its

promoter sequence, which has tissue-specific characteristics, tightly

modulates expression of viral genome in appropriate cell types and

immunoconditions through communication with cellular factors. We

identified the alternative splicing factor, SF2/ASF, as a potential

regulator of JCV as its overexpression in glial cells strongly suppresses

viral gene expression and replication. Our studies have demonstrated

that SF2/ASF expression in glial cells is tightly controlled by immune

mediators secreted by PBMCs suggesting a novel neuroimmune

TUHSC Biology,

Chemistry,

Neuroscien

ce -

Previous

experience

in

biochemica

l lab

techniques

preferred.

10/24/2019 31


Name

Email

Address

Faculty

School or

College

Faculty

Department


Location

Important

selection

criteria

Student

Majors

Desired

Ilker K.

Sariyer

isariyer@te

mple.edu

LKSOM Neuroscience Molecular

regulation of JC

virus

reactivation in

the brain.

Patients undergoing immune modulatory therapies for the treatment

of autoimmune diseases such as multiple sclerosis, and individuals

with an impaired-immune system, most notably AIDS patients, are in

the high risk group of developing progressive multifocal

leukoencephalopathy (PML), an often lethal disease of the brain

characterized by lytic infection of oligodendrocytes in the central

nervous system (CNS). Immune system plays an important regulatory

role in controlling JC virus reactivation from latent sites by limiting

viral gene expression and replication. However little is known

regarding the molecular mechanism of this regulation. My ongoing

studies on JC virus and demyelinating disease, PML, are focused on

understanding the molecular mechanisms involved in regulation of

viral replication and gene expression during the course of JCV

reactivation in immunocompromised individuals, discover potential

biomarkers which will indicate JCV reactivation and develop effective

therapeutic interventions for the treatment of PML.

TUHSC Talented

with good

work ethics,

Biology

Pharmacy

Prasun

Datta

dattapk@t

emple.edu

LKSOM Neuroscience Cross-talk

between HIV-1

and glucose

metabolism

Elucidate mechanism(s) by which HIV-1 protein Vpr modulates

macrophage glucose metabolism. 2. Elucidate mechanism(s) by

which HIV-1 protein Tat modulates microglia and astrocyte glucose

metabolism.

If significant progress is made by the student then he/she will be

allowed to submit an abstract to a national meeting or submit a

manuscript for publication as a contributing author.

TUHSC Willingness

to learn new

techniques. -

Prefer prior

experience

in research.

Biology,

Neuroscien

ce,

Biochemistr

y

Prasun

Datta

dattapk@t

emple.edu

LKSOM Neuroscience Regulation of

glutamate

transporter

EAAT2 in the

context of

NeuroAIDS

Research focuses on determining the role of HIV-1, cytokines and

drugs of abuse in the regulation of glutamate transporter expression

in astrocytes, microglia and macrophages. If significant progress is

made by the student then he/she will be allowed to submit an

abstract to a national meeting or submit a manuscript for publication

as a contributing author.

TUHSC Selection

criteria are

good

organization

al skills,

interest in

learning and

hardworking

. Prefer prior

Biology,

Neuroscien

ce,

Biochemistr

y

10/24/2019 32


Name

Email

Address

Faculty

School or

College

Faculty

Department


Location

Important

selection

criteria

Student

Majors

Desired

Tracy

Fischer-

Smith

tracy.fische

r-

smith@tem

ple.edu

LKSOM Neuroscience Role of systemic

immune

alterations in

the

development of

CNS disease

While the brain is often considered to be "protected" from the body

(periphery), in reality, there is continued communication between

the CNS and periphery. Under healthy conditions, this can aid the

CNS, however, it may have deleterious effects to the CNS in some

disease states, as well as aging. We are exploring the role of altered

systemic immunity in the promotion of CNS injury in HIV infection.

Our previous work suggests that in HIV infection, immune

polarization in the peripheral blood and the brain is associated with,

and likely contributes to, AIDS progression and cognitive impairment.

Our current studies focus on an expanded monocyte subset in HIV

infection and explores the mechanisms for the observed expansion,

as well as how this subset may contribute to disease progression and

CNS decline. We anticipate this work will reveal important insights

into immune polarization and disease pathogenesis, as well as help

identify targets for potential therapeutic intervention.

TUHSC Mature,

serious-

minded,

responsible,

reliable

Biology,

Biochemistr

y

Xuebin Qin xuebin.qin

@temple.e

du

LKSOM Neuroscience Applying a

novel cell

knockout model

for CNS

diseases

Conditional and targeted cell ablation is fast becoming a powerful

approach for studying cellular functions and tissue regeneration in

vivo. Taking advantage of the exclusive IL Y interaction with hCD59, I

have developed a novel tool to investigate the role of specific cells in

the pathogenesis of human diseases. IL Y administration to the

transgenic mice expressing hCD59 in specific cells can be used to

generate this cell ablation model, in which IL Y specifically damages

hCD59-expressing cells in the mice. We can utilize this concept to

develop a new cell ablation model to study the functions of different

cell types under physiologic and patho-physiologic conditions

including cell differentiation and tissue development in many

species. I have established multiple collaborations with Scientists in

USA to further utilize this approach for their research projects in

many species.

TUHSC Working

hard -

Genetics

Cell biology

Genetics or

molecular

biology

10/24/2019 33


Name

Email

Address

Faculty

School or

College

Faculty

Department


Location

Important

selection

criteria

Student

Majors

Desired

Xuebin Qin xuebin.qin

@temple.e

du

LKSOM Neuroscience Applying a

novel cell

knockout model

for CNS

diseases

Conditional and targeted cell ablation is fast becoming a powerful

approach for studying cellular functions and tissue regeneration in

vivo. Taking advantage of the exclusive IL Y interaction with hCD59, I

have developed a novel tool to investigate the role of specific cells in

the pathogenesis of human diseases. IL Y administration to the

transgenic mice expressing hCD59 in specific cells can be used to

generate this cell ablation model, in which IL Y specifically damages

hCD59-expressing cells in the mice. We can utilize this concept to

develop a new cell ablation model to study the functions of different

cell types under physiologic and patho-physiologic conditions

including cell differentiation and tissue development in many

species. I have established multiple collaborations with Scientists in

USA to further utilize this approach for their research projects in

many species.

TUHSC Working

hard -

Genetics

Cell biology

Genetics or

molecular

biology

Bruce

Vanett

Bruce.Vane

[email protected]

mple.edu

LKSOM Orthopaedic

Surgery and

Sports

Medicine

Study of Risk

Factors for

Bleeding in

Knee

Arthroplasty

Patients

In this study, we will review medical record of knee arthroplasy

patients and collect the transfusion information and other clinical

information including pre-transfusion hemoglobin, and other factors

which possibly associated with bleeding.

Then we will analyze the data to identify the risk factors for bleeding

during knee arthroplasty. Based on our results, we will revise our

criteria for ordering blood before the knee arthroplasty and to

decrease unnecessary requests for blood before surgery.

TUHSC Biology

10/24/2019 34


Name

Email

Address

Faculty

School or

College

Faculty

Department


Location

Important

selection

criteria

Student

Majors

Desired

Jian Huang jianh@tem

ple.edu

LKSOM Pathology Tracking blood

stem cell

dividing in

culture

All blood cells arise from a common precursor called the

hematopoietic stem cell (HSC) or blood stem cell. HSC is able to

differentiate into mature blood cells as well as to replenish the pool

of HSCs. Clinically, HSCs are key for bone marrow transplantation for

treating leukemia and other blood diseases. But the number of HSC is

limited in bone marrow and cord blood for transplantation. The

study aims to develop methods that can expand HSC ex vivo and be

used to improve the outcome of clinical bone marrow

transplantations. Experimentally, we use a HSC specific reporter (Evi1-

GFP) to track HSC dividing in culture. Then we treat HSC with a

variety of factors and drugs to test whether they can expand HSC

number ex vivo. Our major goal is to develop new clinical protocols

for expanding functional HSCs for therapeutic applications.

TUHSC This is a

good

opportunity

for the

students

who are

interested in

the stem cell

biology to

learn about

the best

example of

stem cell--

blood stem

cell. The

students can

Biology

Slava Rom srom@tem

ple.edu

LKSOM Pathology microRNA

analysis in

inflammatory

response

Our lab is involved in studying immune responses in mice and

humans during infection and autoimmunity. Standard techniques of

cell processing from mice and human blood for tissue culture and

standard immunological techniques such as qPCR, ELISA, Western

blotting, flow cytometry and immunofluorescence staining of cells

and tissues are performed in our laboratory . The student will be

trained in some of these techniques listed. Basic concepts of these

techniques will be taught and student will be trained to perform the

techniques independently

TUHSC biology,

neuroscien

ce

Yuri

Persidsky

yuri.persids

[email protected]

mple.edu

LKSOM Pathology Blood-brain

barrier injury

and

neuroinflammat

ion

The research in Dr. Persidsky’s laboratory uses mouse and human

models to study blood-brain barrier injury (including

neuroinflammation, tobacco, alcohol and drug abuse). The student

will have the opportunity to learn analysis of microscopic images,

histology, cell culture methods and behavioral testing.

TUHSC Some

laboratory

experience is

preferred

Biology -

Biochemistr

y -

Chemisty

10/24/2019 35


Name

Email

Address

Faculty

School or

College

Faculty

Department


Location

Important

selection

criteria

Student

Majors

Desired

He Wang - He.Wang@

tuhs.templ

e.edu

LKSOM Pathology &

Lab Medicine

Compare

microvascular

disease in right

and left

ventricular wall

at different

time after heart

transplantation

Despite significant improvement in short term survival, cardiac

allograft vasculopathy (CAV) remains the major cause of death in late

survival transplanted patients. The definition of cardiac microvessel

varies between authors, but a vascular diameter < 20 um is believed

to be “micro-” by most investigators. Coronary microvascular bed is

the site where myocardial blood flow is tightly adjusted to meet

myocardial metabolic needs. Coronary microvascular dysfunction is

well documented in hypertension, obesity, diabetes, acute

myocardial infarction, chronic stable angina, cardiomyopathies and

heart failure with preserved ejection fraction.

TUHSC Dedicated -

previous

exposure to

histology

and

morphometr

ic analysis

are

preferred/n

ot absolutely

necessary

biochemica

l science or

neuroscien

ce

Adil I. Khan

PhD

adil.khan@

temple.edu

LKSOM Pathology

and

Laboratory

Medicine

Role of

adhesion

molecules in

acute

inflammation.

In Vitro and in vivo assays would be used to investigate the role of

adhesion molecules in models of acute inflammation.

TUHSC Good writing

skills; be

able to work

independent

ly. the work

may involve

a mouse

models, so

should be

willing to

work with

live animals.

Any science

major.

10/24/2019 36


Name

Email

Address

Faculty

School or

College

Faculty

Department


Location

Important

selection

criteria

Student

Majors

Desired

Wenzhe Ho wenzheho

@temple.e

du

LKSOM Pathology

and

Laboratory

Medicine

Exoosme in

Methampheta

mine and HIV-

associated

Neurodegenera

tion

The proposed studies will reveal previous unidentified mechanisms

by which METH and/or HIV compromise the BBB innate immunity,

providing a favorable micro-environment for HIV neuroinvasion.

TUHSC Prefer to

have

students

with biology

major,

having a

great

interest in

research

(with or

without

experience,

although

research

experience is

preferred).

Students

Biology,

Neuroscien

ce

Domenico

Pratico

praticod@t

emple.edu

LKSOM Pharmacology Dietary lifestyle

and the

Alzheimer's

disease

phenotype

Aging and a family history for the disease are the strongest risk

factors for developing sporadic Alzheimer's disease (AD). In

particular, having a mother with AD poses an individual at a much

higher risk to develop the disease later in life than having a father

with the disease. However, how aging and maternal factor(s) interact

to modulate the susceptibility of developing AD remain unknown.

We hypothesize that maternal dietary lifestyle during gestation is an

important element that influences the susceptibility to develop AD in

the offspring. To address this hypothesis, we will investigate the

effect of different gestational diets on cognitive function in the

offspring; next we will study the effect of the same diet on their age-

dependent development of AD pathophysiology; third we will

determine the mechanism(s) underlying this effect.

TUHSC Highly

motivated.

Interest and

desire to

learn new

concepts

and

techniques.

Good

knowledge

of cell and

molecular

biology.

Some lab

experience.

Biochemistr

y; Biology

10/24/2019 37


Name

Email

Address

Faculty

School or

College

Faculty

Department


Location

Important

selection

criteria

Student

Majors

Desired

Xiao-feng

Yang

xfyang@te

mple.edu

LKSOM Pharmacology Regulation of

vascular

inflammation

and

atherosclerosis

Dr. Xiaofeng Yang’s laboratory, located in the MERB-10th floor-1083,

Centers of Metabolic Disease Research, Cardiovascular Research,

Thrombosis Research and Departments of Pharmacology and

Immunology, focuses on studying the regulatory mechanisms of

vascular endothelial cell, smooth muscle cell, monocyte, adipocyte

and regulatory T cell immune responses related to vascular

inflammation and atherosclerosis. Atherosclerosis is a chronic

autoimmune inflammatory disease characterized by intense

immunological activity, and is the main cause of ischemic stroke and

cardiovascular disease. Cardiovascular diseases and stroke remain as

the leading cause of morbidity and mortality in industrialized society.

There is increasing evidence that vascular endothelial cell

inflammation significantly contributes to the onset and early

development of atherosclerosis. Success of these projects will

provide new molecular targets for future development of new

therapeutics to treat cardiovascular diseases and stroke. Research

projects in Dr. Yang’s lab are to determine how immune cytokine

TUHSC Cardiovasc

ular

Research

Center

Scott Rawls scott.rawls

@temple.e

du

LKSOM Pharmacology

/ Center for

Substance

Abuse

Research

Therapeutic

secrets of

kratom alkaloid

mitragynine:

Testing efficacy

in neuropathic

pain and abuse

liability models

and

characterization

of underlying

opioid and

adrenergic

mechanisms

More than 20 alkaloids, several of which are biologically active, have

been isolated from the Mitragyna speciosa plant known as kratom,

with MG being the major one, accounting for 66.2% of the crude

base and 6% by weight of the dried plant. In Southeast Asia, kratom

has been used for centuries as a stimulant to counteract fatigue and

also as an herbal remedy for depression, pain, opioid withdrawal,

fever, anxiety, and diarrhea. Kratom’s ‘opioid-like’ effects have

gained the most public attention and are presumed to be primarily

responsible for its ‘addictive’ and analgesic properties. However, it is

notable that kratom alkaloids are derived from a coffee-like, not

opioid-like, plant and display both opioid and stimulant properties,

with stimulant effects predominant at low-to-moderate doses and

opioid effects presenting with higher doses. In fact, it is the mixed

opioid/stimulant profile of kratom that makes it so pharmacologically

intriguing, and it is the stimulant properties, likely resulting from

enhanced adrenergic transmission, that are especially understudied

and a principal focus of our proposal. Information about kratom

TUHSC Willing to

conduct

behavioral

research in

rats, mice

and

invertebrate

s

(planarians)

Interest in

studying

mechanisms

underlying

drug

addiction,

identifying

new

neuroscien

ce, biology,

chemistry,

biochemistr

y,

psychology

10/24/2019 38


Name

Email

Address

Faculty

School or

College

Faculty

Department


Location

Important

selection

criteria

Student

Majors

Desired

Conchi

Estaras

conchi.esta

ras@templ

e.edu

LKSOM Physiology Understanding

the regulatory

network that

controls human

cardiomyocyte

differentiation

using hPSCs

Estaras Lab

What we doâ€¦. During heart development, stem cells differentiate

into distinct cardiac cells, including atrial, ventricular and nodal cells.

The right decisions during cardiac cell differentiation are essential for

normal heart development. In some cases, there is an error during

the process of cardiac cell lineage acquisition and that leads to

structural defects of the heart, known as congenital heart disease

(CHD). In our lab, we focus on identifying the molecular mechanisms

that control stem cell differentiation toward specific cardiac lineages.

We aim to decipher signaling pathways, transcriptional and

epigenetic mechanisms that regulate specific cardiac cell fates. We

want to use this knowledge to identify mechanisms and factors

important for cardiac cell development and to provide new tools to

design stem cell-based strategies for cardiac repair.

Why we study this.... Nearly 1% of babies are born with Congenital

TUHSC Biology,

biochemistr

y

Fabio A.

Recchia

fabio.recchi

a@temple.

edu

LKSOM Physiology New

pharmacologica

l and biological

therapies for

heart failure

and atrial

fibrillation

The general aim of this project is to identify new pharmacological

and biological agents for the therapy of heart failure and atrial

fibrillation in experimental dog models. These are two major

pathological conditions that affect millions of Americans and there is

a pressing need for new therapies. Research in large animal models is

called "pre-clinical" in that the related discoveries can be rapidly

translated into clinical practice.

TUHSC Interest in

the

biomedical

field and

potential

interest in

future

medical

studies. At

least the

basic

courses of

biology

biology,

bioenginee

ring,

biochemistr

y,

kinesiology

10/24/2019 39


Name

Email

Address

Faculty

School or

College

Faculty

Department


Location

Important

selection

criteria

Student

Majors

Desired

Jun Yu jun.yu@te

mple.edu

LKSOM Physiology/C

MDR

Check point of

autophagy and

inflammation

The precise mechanisms of ER stress-mediated inflammation and

autophagy are yet fully understood. Nogo-B is a reticulon family

protein mainly localized to ER membrane and is highly expressed in

monocytes/macrophages. Previously, we have shown that Nogo-B

regulates ER morphology, vesicle formation and inflammation. The

objective of this study is to investigate whether Nogo-B regulates

sepsis induced inflammation via controlling autophagy. We will (1)

elucidate the molecular mechanisms of Nogo-B in regulating

autophagy and inflammasome in macrophages in vitro; (2) define the

role of Nogo-B-mediated autophagy in acute inflammation regulation

in vivo. Our study may shed light in developing new strategies in

treating inflammatory diseases.

TUHSC Basic cell

and

molecular

biology

techniques.

Understandi

ng of human

physiology.

Highly

motivated

and

responsible.

Biology or

pharmacol

ogy

Jun Yu jun.yu@te

mple.edu

LKSOM Physiology/C

MDR

Molecular

control of

vascular

remodeling

One of our lab's research focus is to identify novel signaling pathways

that regulate ischemia-induced collateral remodeling and

angiogenesis, one of the major cardiovascular problems. Prohibitin-1

is a highly conserved protein that is mainly localized to the

mitochodrial membrane and regulates mitochondria function and

vascular homeostasis. The subject of this project is to uncover the

role of prohibitin-1 in regulating endothelial cell function and the

underlying mechanism(s).

TUHSC Basic cell

and

molecular

biology

techniques.

Understandi

ng of human

physiology.

Highly

motivated

and

responsible.

Biology or

pharmacol

ogy

10/24/2019 40


Name

Email

Address

Faculty

School or

College

Faculty

Department


Location

Important

selection

criteria

Student

Majors

Desired

Michael

Autieri

mautieri@t

emple.edu

LKSOM Physiology/C

VRC

Gene

expression and

progression of

vascular disease

Restenosis, atherosclerosis, and other vascular diseases are

inflammatory in nature and are regulated by gene expression. We

have found that a number of mRNA stability proteins play a role in

vascular disease. We have generated knock out mice to some of

these proteins to test the hypothesis that mRNA stability proteins

participate in progression of vascular diseases. In this project, the

student will prepare and analyze tissue sections from these mice by

histology and immunohistochemistry to determine if these mice are

protected against vascular disease.

TUHSC manual

dexterity is

important.

ability to get

along with

others.

ability to

follow

directions.

punctuality,

dependabilit

y, honesty,

willingness

to learn new

techniques

are all

important.

Biology,

Biochemistr

y, Pre-med,

Molecular

Biology

George

Smith

george.smit

h@temple.

edu

LKSOM Shriners

Hospitals for

Pediatric

Research/Neu

roscience

Transplantation

of neural stem

cells to

promote circuit

relays in the

injured spinal

cord.

The prospects of inducing long-distance functional regeneration of

supraspinal tracts leading to connectivity and restoration of function

remain a challenge. However, selective treatments induce sprouting,

prevent dieback, or induce short distance regeneration. These

processes, particularly sprouting, contribute to spontaneous

recovery after injury by forming relays onto propriospinal

interneurons that bypass the lesion and connect to caudal locomotor

centers. Similarly, transplantation of neural stem cells or fetal spinal

cord tissue into the lesion site is thought to increase functional

recovery by recruiting supraspinal and propriospinal inputs to

reinforce relays to downstream motor targets. To date, some of the

best functional recovery has been observed in fetal transplants into

neonatal animals most likely through formation of such relays. In

adults, the addition of neurotrophins to the transplant site enhanced

the number of ingrowing supraspinal and propriospinal axons and

enhanced functional recovery, possibly by forming relays to bypass

the lesion. However, it has never been directly shown that

TUHSC Basic

understandi

ng of stem

cells,

immunoche

mistry, and

molecular

biology

Neuroscien

ce, Biology,

or

Chemistry

10/24/2019 41


Name

Email

Address

Faculty

School or

College

Faculty

Department


Location

Important

selection

criteria

Student

Majors

Desired

LIQING JIN jinliqin@te

mple.edu

LKSOM Shriners

Hospitals

Pediatric

Research

Center

molecular

mechanisms of

axon

regeneration in

the lamprey

spinal cord

With molecular biological techniques, we study the role of local

protein synthesis in axonal tips in axonal regeneration in lamprey

spinal cord.

TUHSC Diligent -

biology,

biochemistry

, molecular

biology,

neuroscienc

e, etc. --

Students are

welcome in

our center.

Medicine

or biology

Michael

Shifman

mshifman

@temple.e

du

LKSOM Shriners

Hospitals

Pediatric

Research

Center

Epigenetics

regulation of

axonal

regeneration

The goal of this research is to use the advantages of the lamprey CNS

to test the hypothesis that “good regenerating” RS neurons have

higher levels of histone acetylation, favoring activation of a

regeneration program, whereas histone deacetylation contributes to

regeneration failure after SCI.

TUHSC self-starter,

good

general

laboratory

skills

Neuroscien

ce

Shuxin Li shuxin.li@t

emple.edu

LKSOM Shriners

Hospitals

Pediatric

Research

Center

Neural repair

and CNS

neuronal

regeneration

Our lab is highly interested in neural repair and CNS axon

regeneration research. Our projects focus on the molecular/cellular

mechanisms for CNS neuronal growth failure and development of

novel and effective strategies to promote neuronal regeneration,

remyelination and functional recovery after injury and/or in

neurodegenerative disorders. We employ various in vitro and in vivo

research approaches, including molecular/cellular neurobiology,

biochemistry, genetic and pharmacological methods, transgenic over-

expression and knockout mice and multiple neuronal/axonal lesion

models (such as spinal cord injury, optic nerve crush and EAE) in mice

and rats. We have produced a number of high impact papers related

to CNS axon regeneration and treatments for CNS injury. Our lab is

nationally and internationally recognized for discovering that the

leukocyte common antigen related phosphatase (LAR) is a receptor

for CSPGs and for promoting CNS axon regeneration with available

clinical drugs that suppress Rho and GSK-3 signaling pathways.

TUHSC Motivated

person and

basic

background

on research.

10/24/2019 42


Name

Email

Address

Faculty

School or

College

Faculty

Department


Location

Important

selection

criteria

Student

Majors

Desired

Seo-Hee

Cho

seo.hee.ch

o@temple.

edu

LKSOM Shriners

Hospitals

Pediatric

Research

Center/

Anatomy and

Cell Biology

Examining the

effects of Yap

WT and Yap

mutant genes

overexpression

in the

developing

retina using

AAV (Adeno-

associated

virus) vectors.

This project consists of three parts. First, construction of AAV-Yap

(WT), AAV-YapS1A and AAV-YapS1D via recombinant DNA

technology. Second, expression of Yap, WT and mutant, genes in the

neonatal retina by electroporation or viral injection. Lastly,

characterization of resulting retinas with various analysis tools

including immunofluorescennce assay followed by microscopic

imaging.

TUHSC Biology

Seo-Hee

Cho

seo.hee.ch

o@temple.

edu

LKSOM Shriners

Hospitals

Pediatric

Research

Center/

Anatomy and

Cell Biology

A new LCA

model by

polarity gene

ablation (2)

Genetic analysis

of the

signaligng

genes during

eye

development

Our research focuses on understanding the cellular and molecular

mechanisms underlying the normal development and degenerative

diseases of the mammalian retina. Topics we currently study include:

(I) Functional analysis of apical polarity gene Pals1 during retinal

development. (II) Pathophysiology study of degenerative retinal

diseases (LCA and RP) to understand the underlying disease causing

mechanisms. We are particularly interested in polarity defect in

retinal progenitor cells, which causes early-onset, photoreceptor

degeneration in Leber Congenital Amaurosis 8 (LCA 8) and/or late-

onset Retinitis Pigmentosa 12 (RP12). (III) Cell-transplantation and

gene-based therapies: Our goal is to customize therapy strategies

using cell- and gene-based approaches to restore vision loss in LCA8-

like mouse model in preclinical settings. (IV) Investigating the

function of tumor suppressor genes, TSC2 and Hippo-Yap signal

transduction pathway components, in the eye development.

TUHSC not required Biology

related -

General

Biology

recommen

ded

10/24/2019 43


Name

Email

Address

Faculty

School or

College

Faculty

Department


Location

Important

selection

criteria

Student

Majors

Desired

Nune

Darbinian-

Sarkissian

nsarkiss@t

emple.edu

LKSOM Shriners

Peddiatric

Reserch

Center

Human Brain

Development

and Exposure to

Psychoactive

Medications

and Alcohol

Our group investigates effects of maternal exposure to psychoactive

medications and alcohol during pregnancy on the fetal brain

development. Maternal alcohol (EtOH) exposure can lead to

significant neuronal loss, synaptic dysfunction that can lead to Fetal

Alcohol Syndrome (FAS). Mechanisms of neurotoxicity have been

explored in animal models and in vitro human models, but data from

in vivo human models is scarce. Our group developed unique in vivo

human FAS model to investigate molecular mechanisms of massive

neuronal and synaptic loss, and to identify neurological diseases-

specific miRNAs that upon prenatal alcohol exposure can lead to

Fetal Alcohol Syndrome, depression or Cerebral Palsy (CP). We also

investigate molecular mechanisms in neuroprotection by human

DING protein against alcohol-induced neuronal injury, using various

advanced techniques, including RNA or miRNA studies by

quantitative Real-Time RT-PCR; protein studies including quantitative

western-blot assays and ELISA; fluorescence-based studies including

FACS, Microscopy, and functional bioactivity assays.

TUHSC

Nune

Darbinian-

Sarkissian

nsarkiss@t

emple.edu

LKSOM Shriners

Peddiatric

Reserch

Center

Effects of

Maternal

Alcohol

Consumption

and Gestational

Age on Human

Fetal Brain

Apoptosis

Maternal alcohol (EtOH) exposure can lead to significant neuronal

loss, synaptic dysfunction and fetal alcohol syndrome (FAS).

Mechanisms of neurotoxicity have been explored in animal models

and in vitro human models, but data from in vivo human models is

scarce.

TUHSC Advanced,

motivated,

interested in

research

Neuroscien

ce, Biology,

Pharmacy,

Medical,

Psychiatry,

Gynecology

Sunil

Karhadkar

sunil.karha

dkar@tuhs.

temple.edu

LKSOM Surgery BK virus

nephropathy in

post renal

transplant

biopsy

Analysis of BK virus induced injury in transplant allografts after renal

transplantation. This includes study of immunostains and patterns of

glomerular and tubular injury and correlation with

immunosuppression post renal transplantation. Analysis will include

morphometry and review of renal biopsy as well as biomarkers of

renal injury

TUHSC biology,

biochemistr

y,

chemistry,

immunolog

y

10/24/2019 44


Name

Email

Address

Faculty

School or

College

Faculty

Department


Location

Important

selection

criteria

Student

Majors

Desired

Sunil

Karhadkar

sunil.karha

dkar@tuhs.

temple.edu

LKSOM Surgery Correlation of

pre transplant

renal allograft

histology with

transplant

outcomes after

deceased donor

renal

transplantation

Analysis of donor renal histology with regard to glomerulosclerosis,

vascular changes in intra renal blood vessels and fibrosis; generation

of pathological composite score and its correlation with short term

and long term renal allograft function

TUHSC biology,

immunolog

y

Sunil

Karhadkar

sunil.karha

dkar@tuhs.

temple.edu

LKSOM Surgery /

Abdominal

Transplant

Hypothermia in

donors for

organ

transplantation

and effects on

allograft

outcomes

Hypothermia is often utilized to minimize cerebral injury after

cardiac arrest. Progression to brain death after cardiac arrest and

subsequent organ donation and recovery is associated with variable

outcomes from the procured allografts. The duration of hypothermia

and the ischemia times will be correlated with outcomes after

transplantation

TUHSC Biology,

biochemistr

y,

neuroscien

ce

Sunil

Karhadkar

sunil.karha

dkar@tuhs.

temple.edu

LKSOM Surgery /

Abdominal

Transplant

Obesity and

Frailty as risk

factors for

adverse

outcomes after

renal

transplantation

Study and analysis of indices of frailty as determinants of adverse

outcomes after renal transplantation. This will involve review of

bioinformatics data and statistical analysis and correlation with

serum markers of renal failure, morbidity and graft loss

TUHSC biology,

biochemistr

y

Uma Sajjan uma.sajjan

@temple.e

du

LKSOM Thoracic

Medicine and

Surgery

Innate immune

functions of

airway

epithelium

How does airway epithelium contributes to pathogenesis of chronic

obstructive pulmonary disease (COPD)

Epithelium lining the conductive zone is the first line of defense

against inhaled pathogens, particulates and other enviromental

pollutants. Airway epithelium which was initially thought to be

physical barrier separating the environment from the lungs and to

clear the inhaled pathogens via mucociliary escalator mechanism, is

now recognized as an active participant in detecting inhaled

pathogens and orchesterating innate and adaptive immunity in the

TUHSC Willingness

to work with

small

animals,

such as mice

Good

organization

al skills

Good writing

Any science

major.

10/24/2019 45


Name

Email

Address

Faculty

School or

College

Faculty

Department


Location

Important

selection

criteria

Student

Majors

Desired

Christopher

Thompson

ckt@templ

e.edu

Public Health Physical

Therapy

Quantifying

neural activity

underlying

motor output

This project seeks to quantify both the excitability of and synaptic

input to spinal motoneurons. For this, we use data consisting of the

discharge of several tens of individual neurons gathered from both

animals and humans with and without neurological injury. Primary

analyses will include paired unit analyses, population coherence

approaches, and General Linear Modeling. The student will focus on

the analysis of neural data, but will be encouraged to take part in

experiments and meetings with our national and international

colleagues.

Main Relatively

advanced

knowledge

of

programmin

g is required.

Mastery of

Matlab is

preferred,

though

expertise in

other

languages

will be

considered.

CS,

Math,Physi

cs

10/24/2019 46

Fall 2019 NON-CST Faculty Research ProjectsClass

Preferenc

e

Juniors or

Seniors

Sophomo

re - junior

or senior

10/24/2019 47


Preferenc

e

Sophomo

re, Junior,

Senior

Freshman

,

Sophomo

re, Junior,

Senior

10/24/2019 48


Preferenc

e

Freshman

,

Sophomo

re, Junior,

Senior

Sophomo

re, Junior,

Senior

Freshman

,

Sophomo

re, Junior,

Senior

10/24/2019 49


Preferenc

e

Freshman

,

sophomor

e, junior,

senior

Sophomo

re, Junior

Sophomo

re, Junior,

Senior

Juniors or

Seniors

10/24/2019 50


Preferenc

e

Juniors or

Seniors

Sophomo

re,Junior,

senior

10/24/2019 51


Preferenc

e

10/24/2019 52


Preferenc

e

Freshman

,

Sophomo

re, Junior

Juniors or

Seniors

10/24/2019 53


Preferenc

e

Junior or

Senior

Sophomo

re, Junior

or Senior

Sophomo

re, Junior

or Senior

10/24/2019 54


Preferenc

e

Sophomo

re, Junior,

Senior

Sophomo

re, Junior,

Senior

Juniors or

Sophomo

re

10/24/2019 55


Preferenc

e

Junior or

Senior

Junior &

Senior

10/24/2019 56


Preferenc

e

Freshman

,

Sophomo

re, Junior,

Senior

Junior or

Senior

10/24/2019 57


Preferenc

e

Sophomo

re, Junior

or Senior

Sophomo

re, Junior

or Senior

10/24/2019 58


Preferenc

e

Junior

Junior or

Senior

10/24/2019 59


Preferenc

e

Junior or

Senior

Freshman

,

sophomor

e, Junior,

Senior

10/24/2019 60


Preferenc

e

Junior or

Senior

Sophomo

re, Junior,

Senior

10/24/2019 61


Preferenc

e

Freshmen

,

Sophomo

res -

Junior or

Seniors

Junior or

Senior

Junior or

Senior

10/24/2019 62


Preferenc

e

Sophomo

re, Junior,

Senior

Sophomo

re, Juniors

Junior or

Senior

10/24/2019 63


Preferenc

e

Sophomo

res and

Juniors

Sophmor

e

10/24/2019 64


Preferenc

e

Sophomo

re, Junior

or Senior

10/24/2019 65


Preferenc

e

Sophomo

re, Junior

or Senior

10/24/2019 66


Preferenc

e

Freshman

,

Sophomo

re &

Junior

Sophomo

re, Junior

or Senior

10/24/2019 67


Preferenc

e

Sophomo

re, Junior

or Senior

Sophomo

re, Junior

or Senior

Junior

10/24/2019 68


Preferenc

e

Juniors or

Seniors

10/24/2019 69


Preferenc

e

10/24/2019 70


Preferenc

e

Sophomo

re, Junior

or Senior

10/24/2019 71


Preferenc

e

Freshman

,

sophomor

e, Junior

Juniors or

Seniors

10/24/2019 72


Preferenc

e

Juniors or

Seniors

10/24/2019 73


Preferenc

e

Sophomo

re, Junior

or Senior

10/24/2019 74


Preferenc

e

Junior or

Senior

Sophomo

re, Junior,

Senior

Junior &

Senior

10/24/2019 75


Preferenc

e

Sophomo

re, Juniors

Any

10/24/2019 76


Preferenc

e

Sophomo

re, Junior,

Senior

Sophomo

re,Junior,

senior

10/24/2019 77


Preferenc

e

Sophomo

re, Junior,

Senior

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10/24/2019 78


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10/24/2019 80


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10/24/2019 81


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10/24/2019 82


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10/24/2019 84


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10/24/2019 87


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10/24/2019 89


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10/24/2019 90


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10/24/2019 91


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10/24/2019 92

Documents

Faculty Fall 2019 NON-CST Faculty Research Projects 2020 Non-CST... · biology courses (with lab). Having taken organic chemistry 1 or biochemistry Biochemistr y, Chemistry, Biology,