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Evidence and Causality in the Sciences Conference
AHRC symposiumThursday 6th September 2012
Brendan Clarke
Department of Science and Technology Studies
UCL
'Mechanisms and the Evidence Hierarchy'
Should evidence of mechanisms have a place in the EBM evidence hierarchy?
Four problems with RCTs
• Confounding• Evidence of no mechanism• Design and interpretation• External validity
EBM as an exercise in determining research standards
Which research practices provide the most useful support to the actions of medical practitioners?
Acknowledgements