EVENT SYNOPSIS1

SAN DIEGO, HOTEL DEL CORONADO - NOV 9-12 - 2015

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4 DAYS OF BRILLIANT CONTENT

600 HIGH ENERGY PARTICIPANTS

60 STELLAR FACULTY

50 HOT STARTUPS

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10^9 CONVERSATIONS SPARKED

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From the canvas of images and conversations, Exponential Medicine 2015, was a roaring success. The beachside location at the historic Hotel del Coronado, just outside San Diego, played a prominent role in creating the magic that 550 selected participants from around the world experienced. They were joined by 60+ world class faculty and 55 selected startups for an intense 4 days exploring the cutting edge and future of health and medicine, crossing from wellness and prevention, to the future of diagnosis, therapy and discovery.

I had the honor of curating and chairing this unique and highly interdisciplinary gathering produced by Singularity University which blended a mix of talks, workshops, and hands-on demos with beach side bonding, bonfires, silent-discos, a participant Unconference and more.

Now in our 6th year, our team and conference partners are inspired by the number and quality of relationships, collaborations, new companies, and ideas sparked at this and our earlier gatherings. It’s exciting watching them take hold and create meaningful impact.

We’ve compiled key insights, video links, and summaries from the 2015 Exponential Medicine program to help you wrap your thoughts and actions around all that you experienced during the conference.

Our very best,

Daniel Kraft MDand the entire Exponential Medicine Team

DAYONE

THE FUTURE OF MEDICINE, WHERE CAN TECHNOLOGY TAKE US? ARTIFICIAL INTELLIGENCE • ROBOTICS

BIG DATA & MACHINE LEARNING • MAPPR.IO • BRINGING EXPONENTIALS TO PHARMADIGITAL MANUFACTURING • NANOTECHNOLOGY & NANOMEDICINE

BLOCKCHAIN & DIGITAL CURRENCY • BIOTECHNOLOGY & BIOHACKING RE-IMAGINING DRUG DISCOVERY AND DIAGNOSTICS

SAN DIEGO / 9 NOVEMBER 2015

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If we’re doing our job well, you asked that question many times at Exponential Medicine. It’s easy to imagine the effects of wearables or implantables, but had you considered the impact of big data, machine learning, blockchain, and autonomous vehicles on medicine, health, and care delivery?

Convergence is the key. Consider Uber. They didn’t invent the smartphone, mapping programs, taxi service, or GPS. What they discovered was the convergence point of a group of existing technologies and leveraged them to rethink transportation, create a massive shift in mobility, build a company with a multi-billion dollar valuation and a platform to support greater innovation. We need that type of thinking in health care.

We’re discovering new ways to engage and empower patients and incorporate health care into their daily lives. Telemedicine, augmented reality, and virtual reality can bring care to where people live, work, and play. As the internet of things becomes a reality, millions of sensors and connected devices can provide real-time patient data and machine learning to interpret it and guide decision making at the point of choice.

Wearables. Implantables. The microbiome and the proteome. Pharmacogenomics. Robots, the blockchain, and autonomous cars. CRISPR, robots, AI, and deep machine learning. The future of health care lies in the overlap between these technologies. Convergence is key.

“But what does that have to do with medicine?”

INTRODUCTION TO EXPONENTIALS

Will WeismanExecutive Director of Conferences, Singularity University

Daniel Kraft MDFounding Executive Director and Chair of Exponential Medicine

Brad TempletonDirector and former chairman of the Electronic Frontier Foundation Networks & Computing Chair for Singularity University Founder of ClariNet, the world’s first internet-based business

Neil JacobsteinArtificial Intelligence & Robotics Co-Chair at Singularity University Former CEO of Teknowledge Corporation

Rob Nail Associate Founder & CEO, Singularity University

Jeremy HowardFounder and CEO, Enlitic Former President and Chief Scientist at Kaggle

Kaustuv DeBiswasCo-Founder & Director of Technology, Mappr

SESSION

1

6

“We’ve been delivering reimbursement based medicine, not results based health

care. We need to be proactive, not reactive”

-- Daniel Kraft MD

INTRODUCTION TO EXPONENTIALS

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“You’ll be exposed to a wide range of ideas here. It’s easy to feel intimidated by it, so keep

in mind there was a time when Einstein couldn’t count to 10 and

Shakespeare didn’t know his ABC’s. Even if you haven’t

gotten it yet, you can with time.”

-- Will Weisman

“Our connection with technology is social and is evolving quickly.”

-- Rob Nail

“Last year I said that deep learning was about to change the world.

Today I say ‘it’s happening’”

-- Jeremy Howard

“The human brain hasn’t had a major

upgrade in over 50,000 years.”

-- Neil Jacobstein

“If you are not a software company now; you may not

be a company in the near future. If you are not a software

doctor now; you may not be a doctor in the

near future”

-- Brad Templeton

Stephane BancelChief Executive Officer, Moderna Therapeutics

Katie WeimerVice President, Medical Devices, 3D Systems Healthcare

Andrew HesselFounder, Pink Army; Distinguished Researcher with Autodesk Inc.’s Bio/Nano Programmable Matter group

Chelsea BarabasSenior Advisor for Social Impact, MIT Media Lab

Raymond McCauleyBiotech Track Chair at Singularity University Co-founder & Chief Architect for BioCurious

Atul Butte MD PhDDirector of the Institute of Computational Health Sciences, UC San Francisco

SESSION

2

Technology not only brings us new insights, it overturns commonly held medical myths. mRNA, once thought to trigger violent responses in the immune system is being repurposed to create a cocktail of antibodies in a single dose. Raymond McCauley talked about bio hackerspaces and the exciting field of recreational genomics. At BioCurious, kids are learning to sequence their own DNA and make jellyfish glow in the dark.

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“We’re experiencing a renaissance in biotechnology”

“We’ll be able to replace standard

cancer tests in this decade

and find cancer early enough

to do something about it.”

--Raymond McCauley

“The future of drug discovery is digital”

--Stephane Bancel

The first additive manufacturing patentwas filed in 1892, but we’ve only just begunto discover what 3D printing can do forthe field of medicine and the scale of impact the maker movement will have.

Kate Weimer shared how “maker philanthropy” brings prosthetics to those in need and is growing as a fashion statement. It’s changed the world of optometry. Why not the rest of the medical world? Want a teenage girl to wear her scoliosis brace? Let her design it. Make it fashionable and thin enough to wear under her clothing of choice. Getting patients involved in their treatment improves adherence, and adherence improves health.

Medicine continues to influence culture. 3D printing showed up on “Grey’s Anatomy” this year; 23andMe connects users to a whole world of people with similar genetics. The era of patient involvement is already underway. It’s up to us to harness the excitement and embrace the technology.

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“Biology is nanotechnology that works. Think small!”

“We’re coming to the end of Moore’s Law in 2D. We need to go somewhere else if we want to continue moving forward”

--Andrew Hessel

Take technology into your own hands and see what you can do with it”

--Katie Weimer

“With the Blockchain, we can make ecosystem improvements”

--Chelsea Barabas

We are treading water in a sea of data. By the end of this decade, NASA telescopes alone will be putting out exabytes of data. At this point, the US National Aeronautics and Space Administration is crowdsourcing its astrometric data because it can’t hire enough astronomers. Medicine is at the same juncture.

This has the potential to be an enormous boon for biometric research. Our current classifications are wildly imprecise. Despite the wide and varied number of lung cancers in existence today, we classify them only as “left” and “right”. We can do better. We now have the data to classify them by molecular component.

Let’s do away with the “unknown” classification, or at least shrink it to a manageable size.

People are taking control of their health and their data. Wearables are giving people more and more access to information about their health. If we don’t find a way to access and utilize that information, patients and health consumers will cut us out of the system. Our current drug discovery methods aren’t going to cut it in an exponential world. We need personalized medicine; a Match.com for drugs.

Reimagining Drug Discovery and DiagnosisAtul Butte MD PhD

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“We have the answer to almost everything; the hardest part is finding the question”

“When I think big data, I think retroactive crowdsourcing”

“My doctor’s billion dollar system doesn’t talk to my $40 gadget”

“Big data in biotech is hope”

“We need more garage level startups for biotech. The data is just sitting there”

“I don’t trust any one experiment; I trust what they have in common”

--Atul Butte MD PhD

DAYTWO

SAN DIEGO / 10 NOVEMBER 2015

OMICS, BIOTECH & BEYOND • BODY COMPUTING & COACHING • CROSSING DISCIPLINES CREATING A PANDEMIC OF HEALTH: HOW CAN WE ACHIEVE MASSIVE INDIVIDUALIZATION?

FROM EXPONENTIAL DATA TO INSIGHTS • SCALING INNOVATION ENABLING THE DISABLED & THE FUTURE OF BRAIN/COMPUTER INTERFACE

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While a great deal of medicine is focused on the “what”, it’s also important to ask “why”. Why are we doing what we do? What’s the purpose of all these technologies? We need to be having open, responsible, global conversations about the implications of applied exponential technologies. Refusing to talk about potential downsides of emerging technologies only sets us up for disaster.

Likewise, refusing to talk about the role race, gender, and other factors play in medicine is not only immoral, it’s bad science.

Our genes affect our response to drugs and our susceptibility to disease, and since, as Dr Esteban Burchard reminds us, “we are all rescue dogs”. Widening the pool of clinical trial participants is in everybody’s best interest.

Ask yourself if you’re working on the right problem. If you’re increasing the lifespan without increasing the wellspan, how much does it really matter? Be bold. Consider context and ponder the ethical implications of your work, and don’t let that make you afraid.

OMICS, BIOTECH & BEYONDMoira Gunn PhDHost, NPR’s BioTech Nation

Robert C. Green MD MPHAssociate Professor of Medicine, Harvard Medical School; Director, Genomes2People

Esteban Burchard MD MPHProfessor, UCSF Departments of Bioengineering & Therapeutic Sciences & Medicine

Joel Dudley PhD Professor of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai

Jamie Metzl Chief Strategy Officer, ORIG3N, Senior Fellow, Atlantic Council

SESSION

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“What things are we missing because we’re

focusing on the short term?”

“The next step of precision medicine is precision wellness”

--Joel Dudley PhD

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“Is precision medicine socially precise?”

--Esteban Burchard MD MPH

“I’m an academic as well as a journalist, so first I

want to tell you what, then I want to tell you why.”

--Moira Gunn PhD

“Geneticists are one of the only researchers who are afraid of their own data. We need to confront this head on”

--Robert C. Green MD MPH

“It’s an era where patients have more access to information. That’s good. It raises expectations and empowers patients.”

-- Jamie Metzl

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“If you don’t find yourself stripped down in the

backyard of a total stranger (metaphorically speaking),

then you aren’t playing”

--Moira Gunn PhD

As patients and consumers seek health solutions that interface with their lives, we need to focus on interoperability; gathering the many streams of data coming from multiple unconnected sources and interpreting them in a way that users can understand and act on. Health care has expanded outside the traditional clinic and the physical location has become less important than the convenience of how users access services.

A patient’s social support system has as much, if not more to do with their recovery and quality of life as their doctor or prescribed medications. While we can’t as yet create social networks from nothing, we can create programs and apps that provide support for the unsupported and virtual spaces where isolated patients can begin to build their own social systems.

DIGITAL HEALTH, BODY COMPUTING & COACHING

Aenor Sawyer MDClinical Professor, UCSF Department of Orthopaedic Surgery

Julia HuCo-Founder & CEO, LARK

Robert Bober MDDirector of Nuclear Cardiology, Ochsner Heart & Vascular Institute

SESSION

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“The future is wearables that interface in real time with medical technology.

The clinic will become acute care only.”

--Robert Bober MD

“I want to put a personal health team in

everyone’s pocket”

“Companies like Apple and Google are bringing together your data, so

you don’t have to look at one stream per silo.”

“Remember that your customers deserve

health, understanding and love.”

--Julia Hu

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We hold grand and important goals addressing humanity-level health advances – as well we should – but it’s important that we not lose sight of the health of the individual. In order to do this, we must consider health, not as the absence of disease, but as the ability to adapt and self-manage and not lose sight of the fact that health and medicine are not the same thing. Our aim should be to put individuals back in charge of their of their own health, provide clinical advocacy, and allow self-determination whenever possible.

Health care needs to be a community: an ecosystem instead of an ego system and data needs to escape it’s many, separate buckets, so that we can analyze the big picture, not just a tiny piece. When clinicians step out of their narrow disciplines and work where differing fields converge, that’s when medicine moves forward. When patients connect, share data, and create support networks, that’s how health is created.

CROSSING DISCIPLINESLucien EngelenDirector REshape Center, Radboud University Medical Center

Paul EppingPartner, Philips Healthcare Transformation Services

Alex Jadad MDFounder, Center for Global eHealth Innovation

SESSION

5

“Imagine that 7 billion people could enjoy a happy life until their last breath”

“The pandemic of health is near”

--Alex Jadad MD

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“What if, instead of islands cut off from

each other, we functioned like an engine, where

all the parts work together”

“Ask yourself,

‘how do I become obsolete?’”

--Lucien Engelen

If we use data correctly, we can transform the options people have today. Medicine can be a closed community and language can be difficult for out patients to understand. A lack of understanding leads to a lack of trust, and without trust, we will never create an environment in which individuals take active control of their own health. Technology needs an intuitive interface and a feature set important to it’s primary user group. No matter how advanced a technology is, it won’t be revolutionary if no one uses it.

IBM Watson started out as a Jeopardy champion, which may not seem so impressive on the surface, but when you look deeper, you’ll realize that means “he” has mastered voice recognition, reading comprehension, punning, and the use of a mechanical finger. Watson can run clinical trials, practice law, and answer the phone in call centers around the world. This is significant because as Dan Gordon shared, “people aren’t using Watson to replace people, they’re using him to augment them.”

FROM EXPONENTIAL DATA TOINSIGHTS

Jack Kreindler MDCo founder, Sentrian Remote Patient Intelligence

John Stevens MDCEO, Heartflow

Neil JordanVP of Global Health, Microsoft

Dan Gordon PhDExecutive Consultant, IBM Global Healthcare, Insurance and Life Sciences Center of Competence; Founding Board Chair, Colleaga.Org

SESSION

6

“Technology needs to put people first”

--Neil Jordan

“The triple aim of health care: Improve clinical outcomes, improve patient experience,

reduce the cost of care.”

--John Stevens, MD

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“If we use data correctly, we can

transform the options people have today”

--Jack Kreindler MD

“I don’t know where Watson is going to be on the singularity curve, but where there’s more

information than it’s humanly possible to read, he’s jolly useful”

--Dan Gordon PhD

“Darth Vader: Massive internal polytrauma, quadriplegia, 100% burns, anger issues, and really bad asthma. But with the help of

machine learning, biosensors, and robotics, he lived a full life and almost ruled the galaxy.”

--Jack Kreindler MD

In order to bring these massive amounts of data into focus, we need to go big. It’s time to start creating “plecosystems”, multi-platform ecosystems, to manage and interpret the data coming in from intersecting fields. We need the big institutions to help us out here. The US government is the biggest health care provider in the world; the NHS is the longest enduring. Both are throwing their weight behind advancing health care technology, but learning how to effectively innovate at this scale is an ongoing process. It’s taken Kaiser 45 years to implement Sidney Garfield’s vision of an integrated health system, and there’s still a long way to go. We’re moving digital with everything in the plecosystem and from there, we can take it exponential. The US Federal government has declared all federal data to be public domain. The data is out there, we just need to harness it.

SCALING INNOVATIONJohn Mattison MDAssistant Medical Director & Chief Medical Information Officer, Kaiser Permanente

Mina HsiangHealth Data Advisor, The White House US Digital Service & Office of Science and Technology Policy

Thomas Graham MDChief Innovation Officer, Cleveland Clinic

Tony Young PhD FRCSNational Clinical Director, Innovation at NHS England

Patrick Littlefield Director, U.S. Department of Veterans Affairs Center for Innovation

SESSION

7

“When you can put geographic proximity and cultural alignment together, you can create a space that

advances innovation”

--Thomas Graham MD

“In order to understand big data, we need interdisciplinary teams to communicate the results”

--John Mattison MD

18

“Big data is a reverse Big Bang; all data is converging” --John Mattison MD

Converting massive amounts of data into useable technology, we need to go small. Innovation on the grand scale is important, but we cannot afford to lose individual innovators working on projects for themselves and their communities. We need to support “napkin level” designs. We have the ability to provide data to an unprecedented number of people. If we enable a medical maker movement, we’ll find solutions in places the medical community never thought to look. The plecosystem is vast and tiny; we must provide opportunity at all levels in our quest to create a new world of health.

“Personalized medicine is going to change everything. Over the next

5-10 years . . . the doctor will no longer be the gatekeeper.”

--Tony Young PhD FRCS

“Health care is not driven by what works;

it’s driven by what services are paid for. We are significantly moving the market to a more rational

place.”

--Mina Hsiang

“We have a model of care built around acute

illnesses. That made sense 60 years ago.”

--Tony Young PhD FRCS

19

As an industry, brain/computer interfaces (BCI) are about to take off. On the exponential chart, we’re right at the end of the flat line. While we have a long way to go in realizing the potential, we’ve made huge strides in progress.

In the early days, it started with monkeys and video games. It’s fairly straightforward to teach a happy, healthy monkey to play video games. You just need a joystick and the right kind of fruit juice. After a long, long while, you disconnect the joystick and let the monkey control the game with his brain.

Now, we’re working with humans. We’ve restored a paraplegic’s ability to draw with a Microsoft Paint type program, helped a gentleman with ALS read his email, enabled a woman paralyzed from the neck down to give herself a drink for the first time in years, and watched a woman with locked-in syndrome type out “there is hope”.

In the future, we want to see devices that don’t need an expert technician at the helm, so people can access this technology at home. We want less invasive and more sustainable hardware for these interfaces. We want smaller, faster, cheaper, more accessible.

ENABLING THE DISABLED & THE FUTURE OF BRAIN / COMPUTER INTERFACE

Leigh Hochberg MD PhDProfessor of Engineering, Brown University & Associate Professor, Harvard Medical School

SESSION

8

20

“Think about people who have had injuries and illness that leave them unable to move. What

if we could tap into the desire to move and use that to move something? To tell them, ‘you’ll be

communicating tomorrow.’”

--Leigh Hochberg MD PhD

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DAYTHREE

SAN DIEGO / 11 NOVEMBER 2015

THE MICROBIOME MAY REINVENT MEDICINE AS WE KNOW IT FUTURE OF THE BRAIN & NEUROMEDICINE • GLOBAL HEALTH/HACKING HEALTH

THE FUTURE OF CLINICAL TRIALS, DIGICEUTICALS • DIGITAL TRIALS, BESPOKE THERAPIES REGENERATIVE MEDICINE & LONGEVITY • UNMENTIONABLES, PATIENT & DOCTOR

INCLUDED • LEVERAGING LOW TECH & PIONEERING PREVENTATIVE MEDICINE BRINGING INCENTIVES, BOLD THINKING & ABUNDANCE TO BIOMEDICINE

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This is a wonderful time to be in microbiome research. We’ve only just begun to understand the microbiome and its effect on human health. With autoimmune diseases on the rise, there’s evidence to suggest that this may be related to the effects of antibiotics on the microbiome. At the moment, we only have enough data to show correlation, but it’s strong enough to dig down and see if we can identify causation. What we can say is that the bugs in your gut have an effect on all the regulatory systems in your body. This research has the potential to move us from the antibiotic age into an age of bacterial therapy.

THE MICROBIOME MAY REINVENT MEDICINEAS WE KNOW IT

Lee Stein JDTrustee, XPRIZE Foundation

Paul RobenAssociate Vice Chancellor, Innovation & Technology Commercialization at University of California San Diego

SESSION

9

“The microbiome has the potential to change how we view health and education” --Paul Roben

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“The gut is quite meaningful”--Lee Stein JD

FUTURE OF THE BRAIN & NEUROMEDICINE

Divya Chander MD PhDAnesthesiologist/Neuroscientist, Stanford University

Ariel GartenCEO, InteraXon Inc.

Jamie Tyler PhDCSO and Founder, Thync

Derek HerreraCEO, Spinal Singularity

Arshya Vahabzadeh MDVice President of Health Strategy & Communications, Brain Power

Cori Lathan PhDFounder and Chief Executive Officer AnthroTronix, Inc.

Jordan Amadio MD MBACo-Founder/Partner, NeuroLaunch & Resident Physician in Neurosurgery, Emory University

SESSION

10

Currently, our primary methods of reading the brain are two very old technologies: EEG and FMRI. What we’re learning with them, though is enough to make major advances. Scientists are using brain scans to recreate visual data and for the first time we can quantify the effect of meditation and music on the human brain. Our ability to read and interpret the language of the brain is improving by leaps and bounds.

“We’re about 20 years from rolling into the doctor’s office and

walking out”

“We want patients not to worry about IF they’ll walk again, but instead how long it will take”

--Derek Herrera

24

Our ability to rewrite the brain, however, is in it’s infancy. Deep brain stimulation and mechanical brain computer interfaces are massively invasive, have significant side effects, and often provide only temporary solutions. Currently these therapies are only for those who have exhausted all other options. However, emerging fields like optogenetics have the potential to revolutionize neuroscience and bring brain therapies into the mainstream.

In the near future, we’re going to see neuroscience have a massive effect on preventative care and brain health. Right now, primary care physicians do very little to monitor and improve brain health. Even for those of us who show no symptoms of mental illness, prevention could be key. And for those already suffering, neuroscience and the technologies emerging around it promise huge improvements in standard of care and even the possibility of a cure.

“Technology offers the opportunity not only for a new kind of neuroscience, but a way to take our brain health into our own hands.” --Ariel Garten

“Can we bring the startup culture we see coming out of Silicon Valley to neuroscience?” -- Jordan Amadio MD MBA

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“For any brain interface machine to work, it requires being able to read the brain signals and then rewrite them.”

--Divya Chander MD PhD

Exponential technology gives us hope for solutions to many of humanity’s grand challenges. Infectious diseases like chikungunya are increasing around the globe, temperatures are rising, and potable water is scarce. Even in the developed world, disaster response is limited. Resources are fragmented and we have trouble pinpointing life in dense rubble. Better sensors, mobile technology, and robots all have parts to play in our humanitarian future.

Much of medical technology is unhackable - in the bad way. People are unable to access, modify, and participate in health technology, so the innovation is left to traditional medical companies who have a limited point of view. When people get involved in building their own technology, they illuminate areas where they want help that we might not see. Often we try to build Iron Man when we should be building Spider Man. After all, Spider Man can get dressed by himself.

GLOBAL HEALTH/HACKING HEALTHEric Rasmussen MD MDM FACPCEO, Infinitum Humanitarian Systems

Jose Gomez-MarquezDirector, MIT Little Devices Lab

Manish Kothari PhDPresident of SRI Ventures: VP, SRI International

SESSION

11

“We need a home robot that is a partner as you move along your life path”

“It’s all about dignity, empowerment, freedom, and fun”

--Manish Kothari PhD

“What we need for disaster preparedness: your help”

--Eric Rasmussen MD MDM FACP

“Zoonotic diseases go both ways, and that implicates the epidemiology”

--Eric Rasmussen MD MDM FACP

“Why are office technologies making things more affordable while medical technologies are going in the other direction?”

-- Jose Gomez-Marquez

“Medical technology is generally designed for a black box; it’s not designed for us to understand”

-- Jose Gomez-Marquez

26

Medicine has undergone radical transformation and yet clinical research has changed very little. Clinical trials are now more complex to design, manage, and compensate. In addition, fewer patients are enrolling in trials and retention rates are dropping. Why? We’ve pinpointed three major factors: geography, awareness, and trust.

Technology offers solutions to all three issues. In addition, it gives us the ability to expand research and improve results. We now live in a world where we can understand what the patient is doing outside the clinic. We can bring the trial to the patient and allow them insight into the process. We can improve not only recruitment, but diversity. If we can learn how to parse a hashtag and interpret an emoji, we’ll be in an even better position to hear what our patients are telling us.

THE FUTURE OF CLINICAL TRIALS, DIGICEUTICALS & BEYOND

Komathi StemStrategic Innovation Leader, Genentech

Milind KamkolkarGlobal Head Next Gen Analytics at Novartis

SESSION

12

“If we truly aim to be customer centric, we need to realize that we are not

the only people in the world with an opinion; we need to shift toward

active listening”

--Milind Kamkolar

“Empowered patients are the right ingredient

to exponentially improve clinical trials”

“There are plenty of patients living in hope who

are willing to participate if given a chance.”

--Komathi Stem

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DIGITAL TRIALS, BESPOKE THERAPIESDonald JonesChief Digital Officer, Scripps Translational Science Institute

Scott SummitDirector of Technology, Bespoke Products and Design Director, 3D Systems

Eythor BenderCEO, Unyq

SESSION

13

Patients are taking control of their own care needs. This is changing everything from the location of the clinic and the role of the primary care provider to the manufacturing of casts and prosthetics. Digital manufacturing has been making inroads in medicine for many years now. One of the biggest benefits is that complexity is free and personalization is cheap. This means that things not only fit better, but they can be beautiful. The healing process doesn’t have to be painful; prosthetics don’t have to be merely functional, and braces don’t have to be ugly.

“We’re giving a whole new dimension to

wearing prosthetics. For the last 13 years,

it’s been cookie cutter, non-personalized

products. We’re getting to the point where people finally get to be themselves.”

--Eythor Bender

“Medicine gets imposed on you; fashion is something you have agency in.”

“[A customized prosthetic] leg is load bearing, beautiful, stigma reducing, recyclable, and dishwasher safe.”

“The goal is not to improve the medicine; the medicine works. The goal is to improve adherence”

--Scott Summit

“50% of people in the US don’t have a primary care

physician. 50% of the remaining can’t name a doctor they saw in the

last two years.”

--Donald Jones

28

Sequencing the human genome has become exponentially faster and cheaper. Human Longevity, Inc has sequenced over 10,000 genomes, looking for the key to extending human life. Within the human genome lies the code to the diseases we experience and the possibility of delivering personalized medicine. By sequencing cancer tumors, we can design treatments to specifically target each one. The secrets of humanity are written in the genome, and we are almost ready to read them.

Stem cells will play a significant role in human longevity. Once we fully harness their capabilities, their ability to self renew and differentiate downstream, all sorts of damaged cells will be repaired and replaced from re-generated ones. From there, the next step is to “ceuticalize” the cells. Perhaps in the future, we’ll even see stem cells used in gene therapy, powering the cure for genetic disorders.

REGENERATIVE MEDICINE& LONGEVITY

Daniel Kraft MDChair of Medicine & Neuroscience, Singularity University

Brad Perkins MD MBAChief Medical Officer, Human Longevity Inc

Yaron Turpaz PhDChief Information Officer, Human Longevity Inc

SESSION

14

“Your genome should be part of your daily health care.” --Yaron Turpaz PhD

“Innovation is often driven by our own needs”

“Longevity is the ability to repair, regenerate,

and replace lost or damaged parts”

--Daniel Kraft MD

“We’re building the Google Earth of the body”

--Brad Perkins MD MBA

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“Your selfies can save you”

“My doctors can see my genome, my university colleagues can see my genome,

but I can’t.”

“I had awake brain surgery, and I taped it. Watch this!”

--Steven Keating

“ Illness starts with I; wellness starts with we ”

--Steven Eisenberg MD

In reality, most of life happens between medical visits. It’s asking a lot for patients to focus on their health when they’re dealing with a daily case of “life sucks”. When we provide tools for patients to function in their reality, only then can we realistically expect them to actively engage in their health care.

It is maddening how little access patients have to their own data. Lack of access actively discourages patient engagement, which is the opposite of what we strive for. Allowing patients to access and share their data is good for them, for their support system, and for medicine. The more data we can gather and share, the faster we’ll advance. If a mere .001% of Facebook’s users had access to their data and agreed to share it, it would be the largest medical study in history.

UNMENTIONABLES, PATIENT & DOCTOR INCLUDED

Alexandra DraneCo-Founder, Chief Visionary Office & Chair of the Board of Eliza Corporation

Steven KeatingDoctoral Student & Researcher, MIT Media Lab

Steven Eisenberg MDChief Medical Officer and Co-founder, Workup

SESSION

15

“The unmentionables: sex, drugs, and a crappy boss”

“Expand your definition of health to include life. When life goes wrong, health goes wrong.”

--Alexandra Drane

30

“There’s plenty of money in health care;

it’s just being put in the wrong places”

--Peter Diamandis MD

“The sheer number of people dying from lifestyle diseases diverts resources from the diseases that can only be treated with medications”

“If all we are as doctors is a collection of algorithms, then

we’ll be replaced by an iPhone”

--Dean Ornish MD

Big data, machine learning, and a wealth of emerging technologies confirm just how effective low tech solutions can be. Not only are they often equally, if not more effective than medication, they often prove more sustainable, and very rarely come with negative side effects. The challenge is that they require more engagement from both the patient and the doctor. The patient must take greater responsibility for their level of health and illness with the doctor providing both support and access to support. Make it feel good; make it fun; make it loving and supportive, and it will be sustainable.

We don’t lack resources. We’re surrounded by resources. What we lack is the ability to harness them. That’s where exponential technology comes in. More importantly, it’s where exponential thinking comes in.

We evolved in a linear world, and our way of thinking can keep us trapped there. But we are, in fact, living in a world of exponential abundance. Learn to think abundantly, and, as much as possible, surround yourself with others who think abundantly. That’s how we change the world.

“There are two systems that are going to be crushed this decade:

health care and education”

--Peter Diamandis MD

Leveraging Low Tech & Pioneering Preventative Medicine Dean Ornish MDFounder & Director, Preventive Medicine Research Institute & Clinical Professor, UCSF

Bringing Incentives, Bold Thinking, Abundance to BioMedicinePeter Diamandis MDCo-Founder, Singularity University & CEO, XPrize

SESSION

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SESSION

17

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THE MEDy AWARDS RECOGNIZE COMPANIES DESIGNING PRODUCTS AND CREATING HEALTHCARE SOLUTIONS THAT ARE INDUSTRY-CHANGING INNOVATIONS

“Healthcare is on the cusp of exciting changes as new technologies truly alter how medical care is provided to patients. These innovations will solve challenges present in the current system.

The MEDy awards are presented to companies generating disruptive and game changing solutions and driving innovation in the medical field.”

--Daniel Kraft MD, Exponential Medicine Conference Chair

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MEDyAWARDS

DAYFOUR

EXPONENTIAL THINKING, A CONVERSATION WITH RAY KURZWEIL AR/VR & VISIONING THE FUTURE OF MEDICAL EDUCATION

UNUSUAL INTERSECTIONS CROWDSOURCING IN HEALTHCARE

ESSENTIAL PRACTICES FOR HEALTHCARE INNOVATION

SAN DIEGO / 12 NOVEMBER 2015

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EXPONENTIAL THINKING: A CONVERSATION WITH RAY KURZWEIL

Ray KurzweilDirector of Engineering, Google Co-Founder & Chancellor of Singularity University

SESSION

18

“The cutting edge will always be

expensive, but very close on its heels

are very high quality open source options

that are free”

--Ray Kurzweil

“The same technologies that

are going to extend lifespans are also going to increase

resources”

--Ray Kurzweil

Radical life extension isn’t enough. We also need radical life expansion, otherwise progress is pointless. Right now, anyone with a smartphone can access all of the world’s information with a few keystrokes. With our current technology developments, someday we’ll be able to access all that information and more directly from our neocortex.

Some of this technology is closer than you think and some is further away, but all of it is coming. Human beings are different from any other species in that not only do we create, we also use our power of creativity to expand our abilities beyond our limitations.

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Telemedicine is well established, technologically speaking. It just hasn’t infiltrated the common practice yet. When it does, it will revolutionize how we practice. Telemedicine reduces wait times and delivers care to where in locations convenient to both patients and caregivers. Why require people to travel and wait when an appointment doesn’t require touch? Basic readings can be taken in the patient’s environment of choice using mobile or wearables and sent to the care team upon request.

We shouldn’t overlook simple solutions that make a world of difference. Something as basic as adding automated patient check-in that sends an alert directly to the clinician’s wearable device can streamline service and reduce wait times. No need to wait for more advanced, complex technologies when we can enact better, faster, cheaper processes right now.

AR/VR & VISIONING THE FUTURE OF MEDICAL EDUCATION

Rafael Grossmann MD FACSSurgeon & Google Glass Pioneer

Shafi Ahmed PhD FRCSConsultant Surgeon

David Metcalf PhDDirector of the Mixed Emerging Technology Integration Lab (METIL), UCF’s Institute for Simulation and Training

Kevin Sneed PharmDSenior Associate Vice President, University of South Florida Dean, University of South Florida, College of Pharmacy

SESSION

19

“Every 10 years, we pull off what Hollywood imagines. Big Hero 6 is coming.”

-- Rafael Grossman MD FACS

“A picture is worth a thousand words. A video is worth a thousand pictures”

-- Rafael Grossman MD FACS

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Augmented and virtual reality also have the ability to alter how we teach and test. Google Glass allows us to stream live surgeries to a greatly expanded audience - and nobody has to stand in the back row. Students without access to expensive equipment and medical facilities can practice complex procedures. Wearables have already far outpaced our ability to make use of the data they produce. Just think how we can redefine clinical trials when we finally catch up.

“Our students are moving ahead, whether we’re with them or not”--David Metcalf PhD

“Instead of waiting 90 days to see if a diabetic medication is

working, we can know by day 14.”

--Kevin Sneed PharmD

“Combining 360 video, 3D and interactive content, any student can be at the bedside and view the operation through the surgeon’s eyes. That’s how we make education exponential!” --Shafi Ahmed PhD FRCS

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Our current healthcare system is not only broken, it’s unsustainable. Costs and mortality rates are rising at the same time, and those costs are more and more being borne by individuals. We can’t just tinker with the system; we need to dismantle it and build a new one from the ground up. We have the ability; we have the technology; now we just need the will. Commit first. Figure it out later. It’s the only way.

UNUSUAL INTERSECTIONSGautam Gulati MD MBA MPHFounder of the Unusual Group

Pritpal S Tamber MBChBFounder, Creating Health Collaborative

SESSION

20

“Treat the sick. Prevent disease. Create health.”

--Pritpal S Tamber MD

“We have all the ingredients; it’s up to us to assemble these ingredients in a way that makes them consumable for the end user”

--Gautam Gulati MD MBA MPH

“For every 1% the income gap increases, the mortality rate in the lower group increases 4%. The rich get richer and the poor die sooner.

That’s a first world story.”

--Pritpal S Tamber MBChB

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We’ve talked a lot about big data and machine learning this week, and while technology is going to be an integral part of tackling the massive amount of data available today, there’s another solution: a massive number of people. The wisdom of the crowd contains the answers to many of our most difficult medical issues. By crowdsourcing difficult diagnoses, we can bring the best, correct, culturally appropriate, difficult-to-discover treatment to desperate patients better, faster, and cheaper.

The new economy is being built on excess capability, be it Uber using your car’s downtime or AirBnB making use of your spare room. The smartest people in the world don’t work for you; they’re out in the crowd, and often, they’re willing give you some of

their excess capability. In the next few years, we’ll add another three billion people to the networked crowd. What could we do with all that capability and capacity? And what are the second order effects and benefits of a new economy? Anywhere Uber launches, the city sees a drop in DUIs. What unintended benefits can crowdsourcing bring to the heath ecosystem?

CROWDSOURCING IN HEALTHCAREAND BEYOND

Marcus ShinglesPartner, Deloitte Consulting Innovation

Jared HeymanFounder & CEO, CrowdMed

Laurence AinouzGlobal Head, Digital Acceleration Lab at Novartis

SESSION

21

“What is the excess capability of your organization?” --Marcus Shingles

“How do you leverage the genius of the crowd? We need to because that’s where genius lives.” --Marcus Shingles

“The truth is that no doctor, no matter how brilliant, can

keep up with the massive amounts of medical knowledge

available today.”

--Jared Heyman

“What’s needed to save life is a bunch of people who want to help.

Hopefully at least one on every street.”

--Laurence Ainouz

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Innovation isn’t a mystery and it isn’t magic. It’s a knowable, learnable, teachable, quantifiable skill which you should be implementing in your organization with the same care and metrics that you would any other tool in your toolbox. Audit your organization; get a baseline, and then refer back to it when assessing your progress. Keep in mind that protocols matter. They keep airplanes in the sky and they keep your corporate innovation on track. Focus in on a manageable number of great ideas, and don’t be distracted by the rest. Strive to be both bold and effective.

Consider the coral reef. It is a self organizing, self optimizing system with no center. Fish don’t have business meetings, but they sure do get stuff done. Your organization should work the same way. Open your data to smart people. Consider how any technology you’re using or developing can connect to the ecosystem. If your idea can’t connect with others, it probably isn’t a great idea. Frame your innovation in a way that is consistent, systematic, connected, and measurable. This is your chance to be at the vanguard of a new world. Take it.

ESSENTIAL PRACTICES FOR HEALTHCARE INNOVATION

Larry KeeleyPresident, Co-Founder at Doblin GroupDirector of Deloitte Consulting

SESSION

22

“Collectively, our job now is to figure out how to think about

things in a really deep way and act on them

in a really practical way”

“When the history of 21st century business is written, it will be the age in which business solutions

gave way to business ecosystems”

“The world is creating a steady stream of old things, when

what we really need is radically new things”

“All of the innovations that are going to revolutionize medicine

are going to behave as ecosystems.”

--Larry Keeley

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HEALTHCARE INNOVATION

LABPROMISING COMPANIES AND INNOVATIONS SET TO REVOLUTIONIZE THE PRACTICE

OF MEDICINE AND RADICALLY TRANSFORM THE BIOMEDICAL INDUSTRY

50 CUTTING-EDGE, EARLY-STAGE COMPANIES

CURATED THROUGH INVITATION, NOMINATION, AND APPLICATION

HANDS-ON LEARNING AND DEMONSTRATIONS

GRATITUDE TO OUR PARTNERS, COLLABORATORS AND PARTICIPANTS

P LAT I N U M PA R T N E R O F T H E E X P O N E N T I A L C O N F E R E N C E S E R I E S

M A J O R P A R T N E R S O F E X P O N E N T I A L M E D I C I N E

E X P O N E N T I A L M E D I C I N E PA R T N E R S

P LAT I N U M PA R T N E R S O F E X P O N E N T I A L M E D I C I N E

THANKS

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PARTICIPANT COMMENTS

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“Mind-expanding, futuristic, welcoming and fun” -- Alistair Quinn, The University of Queensland

“I came to Exponential Medicine a little skeptical, but left with my head exploding with thoughts,

ideas and inspirations, the result of an intriguing collection of brilliant colleagues, aspirational startups,

engaging and diverse presenters organized in a truly unique experience.”

-- Ed MacBean, Senior Manager Market Development – Population Sequencing, Illumina Inc

“This is a dynamic and intellectually energizing experience. It changes the way you view medicine and life in general.”

-- Farzad Massoudi, Medical Director, Neuroscience and Spine Institute

“Just have to share what a beautiful and long half-life xMed is having...

I am carrying the glow of all I learned and the energy, vibrance, collaborative and feisty spirit of

the TOTALLY KICK A** xMed community you’ve created. Now I know what all the fuss is about!!”

-- Alexandra Drane, Founder of ElizaCorp

“Stimulating and disruptive yet appropriate and real.” -- Jared Heyman, CEO CrowdMed

“Game Changing experience designed to trigger curiosity and the right questions

for those who want to create change.” -- Nikolaus Weil, Managing Partner,

Alphabridge Capital

“Worth every dime we invested” -- Chuck Divita, Guidewell CFO

JOIN USOCT 8 - 11, 2016

SAN DIEGO / HOTEL DEL CORONADO

46

Singularity University (SU) is a benefit corporation headquartered at NASA’s research campus in Silicon Valley. We provide educational programs, innovative partnerships and a startup accelerator to help individuals, businesses, institutions, investors, NGOs and governments understand cutting-edge technologies, and how to utilize these technologies to positively impact billions of people.

Since our inception in 2008, SU has empowered individuals from more than 85 countries to apply exponentially growing technologies, such as biotechnology, artificial intelligence and neuroscience, to address humanity’s grand challenges: education, energy, environment, food, health, poverty, security, space and water. In just six years, our alumni, partners and members have generated more than 100 startups, and numerous patents and ideas to help advance this mission.

S I N G U LA R I T Y U N I V E R S I T Y F O U N D I N G C O R P O R AT E PA R T N E R S

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GLOBAL GRAND CHALLENGES

ENERGYAmple, accessible and sustainable energy for the needs of humanity.

FOODConsumption of sufficient, safe and nutritious food to maintain healthy and active lives for all

people at all times.

HEALTHOptimal physical and mental

health, including access to cost effective prevention, early

diagnosis, and personalized therapy for individuals and

communities.

WATERAmple and safe water for

consumption, sanitation, industry, and recreation for all people at all

times.

SECURITYSafety of all people from

physical and psychological harm, including in virtual worlds; and protection of physical, financial, digital

systems.

ENVIRONMENTSustainable and equitable

stewardship of Earth’s ecosystems for optimal

functioning both globally and locally.

LEARNINGAccess to information and

experiences that build knowledge and skills for all people at all stages of their lives for personal fulfillment

and benefit to society.

SPACESafe and equitable use, and

stewardship of, space resources and technologies for the benefit of humanity and our future as a

multi-planetary species.

DISASTER RESILIENCEEffective and efficient disaster risk reduction,

emergency response, and rehabilitation that saves lives and livelihoods, minimizes economic loss, and builds resilience both

globally and locally.

GOVERNANCEEquitable participation of all people in

formal and societal governance in accordance with principles of justice and individual

rights; free from discrimination and identity-based prejudices; and able to meet the needs

of an exponentially changing world.

PROSPERITYEquitable access to economic

and other opportunities for self-fulfillment where all people are free

from poverty.

The world needs an organization dedicated to addressing serious global issues by fully embracing the power and capacity of disruptive and exponentially growing technologies. Singularity University was founded in 2008 by Peter Diamandis and Ray Kurzweil to do just that.

Exponential technologies demonstrate continued accelerating growth of capabilities—speed, efficiency, cost-effectiveness or power. We apply these technologies to Global Grand Challenges with a strong understanding of social, cultural, economic, political and environmental factors.

The Exponential Conference Series takes Singularity University’s unique vantage point and focuses it upon the exponentially accelerating technologies that are impacting individual verticals such as finance, health & medicine, and manufacturing.

Learn more at exponential.singularityu.org

June 6 - 7, 2016NYC

Conrad Hotel

October 8 - 11, 2016San Diego

Hotel del Coronado

May 10 - 11, 2016Boston

Westin Waterfront

Aug 28 - 30, 2016San Francisco

Hilton San Francisco Union Square

ExponentialMedicine@SingularityU.org

@ExponentialMed #xMED

facebook.com/ExponentialMedicine

ExponentialMedicine

ExponentialMedicine.comSAN DIEGO / 8-11 OCTOBER 2016