ABSTRACTCholesterol and triglycerides, important lipid constituents of cell are essential to carry out several vital physiological functions. In some malignant diseases blood cholesterol and hemoglobinundergoes early and significant changes. In the present study Total cholesterol, HDL and Hemoglobinwere determined in oral precancer and healthy individuals. Total cholesterol, HDL and hemoglobinlevels were significantly lower in oral precancer patients as compared to the controls.KEY WORDS: Oral precancer (OPC), cholesterol, high density lipoprotein (HDL), hemoglobin.