Evaluation of Evaluation of thethe resistance of resistance of bacterial pathogensbacterial pathogens of of synopulmonary infections in synopulmonary infections in childrenchildren

L.ChernyshovaF.Lapiy

National Medical Academy of Postgraduate Education (Kyiv, Ukraine)

BackgroundBackgroundBacterial resistance creates a

challenge for clinicians from the viewpoint of correct and successful management of patients.

Antibiotic resistance is an important consideration when treating bacterial infections and there is some evidence that resistance is becoming more widespread.

BackgroundBackgroundEtiologic diagnosis is often

unreliable; consequently, clinicians must know epidemiology of respiratory infections for optimizing empiric antibiotic therapy. 

In recent years, all major respiratory bacterial pathogens have become more and more resistant to conventional antibiotics.

BackgroundBackgroundS.pneumoniae and H.influenzae are

the two most important bacterial causes of respiratory infection.

Penicillins and macrolides are the antibiotics most commonly used to treat such infections.

Penicillin-resistant and even multiresistant pneumococci have spread worldwide

Unfortunately, data on antibiotic resistance of S. pneumoniae or Hib in Ukraine are limited

BackgroundBackgroundPneumonia, septicemia,

meningitis are considered an important public health problem in Ukraine

Lack of evidence of Hib disease burden in Ukraine has delayed the introduction of vaccines

BackgroundBackgroundHib conjugate vaccination was

introduced in Ukraine in 2006.Mortality from pneumonia, meningitis,

septicemia decrease more then 2 time then Hib vaccination was introduced

According to the results of the case-control surveillance of Hib-vaccine effectiveness against pneumonia (sponsored by WHO) was more then 50%.

BackgroundBackgroundVaccination against pneumococc

al infections in children has not been introduced in Ukraine

Healthcare providers have little information about pneumococcal infection (burden, resistence) and may not consider the vaccine a priority.

PCV vaccines in UkrainePCV vaccines in UkrainePCV7 conjugate vaccine was

licensed in Ukraine in 2010PCV13 conjugate vaccine under

registration

Objective Objective To investigate the pathogenic

bacterial spectrum responsible for respiratory infections and their drug resistance in children.

Our plansOur plansWe are beginning research to

study the burden of pneumococcal infection among children.

We plan to explore the serotypes of S.pneumoniae, susceptibility to antibiotics, the prevalence of carriage of S.pneumoniae.

Expected benefitsExpected benefitsInformation on the burden of

pneumococcal infection, the prevalence of antibiotic-resistant strains will allow us to rationally use antibiotics in the treatment of respiratory infections and decide on the introduction of vaccination against pneumococcal infection

Welcome to collaboration!Welcome to collaboration!