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European HIV/AIDS programmes: EDCTP as a model of Europe-Africa partnership
19 July 2011IAS 2011Rome, Italy
Charles S MgoneEDCTP Executive Director
About EDCTP
• Partnership between European member states, European Commission and Africa in collaboration with like minded organisations in fighting diseases of poverty – HIV/AIDS, malaria and tuberculosis
• This is realised by funding clinical trials and research capacity to accelerate development of intervention tools including drugs, vaccines, microbicides and diagnostics against these diseases
The partnership
• Benin• Botswana • Burkina Faso• Cameroon• Congo• Cote d’Ivoire• Democratic Republic of Congo• Ethiopia• Gabon• Ghana• Guinea• Guinea-Bissau• Guinea-Conakry• Kenya• Liberia• Madagascar• Malawi• Mali
• Mozambique• Namibia• Nigeria• Rwanda• Senegal• South Africa• Sudan• Tanzania• The Gambia• Togo• Uganda• Zambia• Zimbabwe
• Austria• Belgium• Denmark• France• Germany• Greece • Ireland• Italy• Luxembourg• Netherlands• Norway• Portugal
• Spain • Sweden• Switzerland• United Kingdom
EDCTP-EEIG member states
Sub-Saharan African countries
EDCTP Regional Networks for Clinical Trials
Western Africa: WANETAMWebsite: www.wanetam.org Project Coordinator: Prof. Soleymane Mboup• Burkina Faso• The Gambia• Ghana• Guinea-Bissau•Mali• Nigeria
• Senegal• United States
Southern Africa: TESAWebsite: www.tesafrica.orgProject Coordinator: Dr Alexander Pym• Botswana• Malawi • Mozambique • South Africa • Zambia • Zimbabwe • France
• Germany• Netherlands• United Kingdom
Eastern Africa: EACCRWebsite: www.eaccr.orgProject Coordinator: Dr Pontiano Kaleebu• Kenya• Sudan• Ethiopia• Tanzania• Uganda• Germany• Sweden
• United Kingdom• United States
Central Africa: CANTAMWebsite: www.cantam.orgProject Coordinator: Prof. Francine Ntoumi• Cameroon• Congo, Republic of the• Gabon• France• Germany
Funded projects including clinical trials 2003-2011
•Treatments
13
•Vaccines
9•Mi
crobicides
4
HIV/AIDS26 clinical trials
108.30 M €
•Treatments
7 •V
accines
7•D
iagnostics
4
Tuberculosis18 clinical trials
103.33 M €
•Treatments
10
•Vaccines
2
Malaria12 clinical trials
69.63 M €
EDCTP has funded 174 projects in 29 African countries including 56 clinical trials on HIV/AIDS, malaria and TB
HIV/AIDS treatment and prevention trials
• Evaluation of paediatric formulations: fixed drug combinations/scored dispersible tablets
• Evaluation of second-line treatment
• HIV/TB co-infections
• Prevention of Mother to Child Transmission of HIV (PMTCT)
HIV preventive vaccine trials
• Capacity building in preparation for HIV vaccine trials- Joint EDCTP/BMGFgrant
• DNA+MVA-CMDR (rgp 140/GLA-AF) phase I/II clinical trial (TaMoVac + AfrEVacc) in healthy young adults
• DNA + MVA-HIVA phase I/II in healthy infants born to
HIV1 and HIV2 uninfected and infected mothers
Microbicide trials
• Site preparation/capacity strengthening
• Establishment of cohorts
• Characterisation of novel safety markers
• PRO 2000 vaginal gel phase III clinical trial
EDCTP-II
• Consolidation of the current focus on clinical trials• Phase II and III clinical trials
• Expansion to phase I and IV clinical trials• Health services/optimisation studies• Neglected Tropical Diseases including co-morbidities
• Open collaborative projects with other developing countries beyond sub-Saharan Africa