MM4TBProject reference: 260872Funded under: FP7-HEALTH

More Medicines for Tuberculosis

From 2011-02-01 to 2016-01-31, ongoing project

Project details

Total cost:

EUR 16 695 126,34

EU contribution:

EUR 11 873 052

Coordinated in:

Switzerland

Topic(s):

HEALTH.2010.2.3.2-1 - Target characterisation and hit-to-lead progression in tuberculosis (TB) Drug development. FP7-HEALTH-2010-single-stage

Call for proposal:

FP7-HEALTH-2010-single-stage

Funding scheme:

CP-IP - Large-scale integrating project

Objective

"The More Medicines for Tuberculosis (MM4TB) consortium evolved from the highly successful FP6 project, New Medicines for TB (NM4TB), that delivered a candidate drug for clinical development two years ahead of schedule. Building on these firm foundations and exploiting its proprietary pharmacophores, MM4TB will continue to develop new drugs for TB treatment. An integrated approach will be implemented by a multidisciplinary team that combines some of Europe's leading academic TB researchers with two major pharmaceutical companies and four SMEs, all strongly committed to the discovery of anti-infective agents. MM4TB will use a tripartite screening strategy to discover new hits in libraries of natural products and synthetic compounds, while concentrating on both classical and innovative targets that have been pharmacologically validated. Whole cell screens will be conducted against Mycobacterium tuberculosis using in vitro and ex vivo models for active growth, latency and intracellular infection. Hits that are positive in two or more of these models will then be used for target identification using functional genomics technologies including whole genome sequencing and genetic complementation of resistant mutants, yeast three hybrid, click chemistry and proteomics. Targets thus selected will enter assay development, structure determination, fragment-based and rational drug design programs; functionally related targets will be found using metabolic pathway reconstruction. Innovative techniques, based on microfluidics and array platforms, will be used for hit ranking, determining rates of cidality and confirming mechanism of action. Medicinal chemistry will convert leads to molecules with drug-like properties for evaluation of efficacy in different animal models and late preclinical testing."

Related information

Result In Brief New drugs for tuberculosisPage 1 of 6

Researchand Innovation

http://cordis.europa.eu/programme/rcn/852_en.htmlhttp://cordis.europa.eu/programme/rcn/12550_en.htmlhttp://cordis.europa.eu/result/rcn/92179_en.html

Report Summaries Periodic Report Summary 3 - MM4TB (More Medicines for Tuberculosis)

Periodic Report Summary - MM4TB (More Medicines for Tuberculosis)

Coordinator

BATIMENT CE 3316 STATION 1LAUSANNE, Switzerland

Administrative contact: Stewart ColeTel.: +41216931851Fax: +41216931790E-mail

EU contribution: EUR 2 301 083,2

ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE Switzerland

Participants

"'AVISHKAR', BELLARY ROAD"BANGALORE, India

Administrative contact: Tanjore BalganeshTel.: +91 80 2362 2001Fax: +91 80 2362 2002E-mail

EU contribution: EUR 742 191,5

AstraZeneca India Pvt Ltd. India

St Olofsgatan 10BUPPSALA, Sweden

Administrative contact: Leif KirsebomTel.: +46 18 471 4068Fax: +46 18 530396E-mail

EU contribution: EUR 700 000

UPPSALA UNIVERSITET Sweden

STRADA NUOVA 65PAVIA, Italy

Administrative contact: Sofia BagginiTel.: +39 0382 984202Fax: +39 0382 984633E-mail

EU contribution: EUR 600 000

UNIVERSITA DEGLI STUDI DI PAVIA Italy

"The Old Schools, Trinity Lane"CAMBRIDGE, United Kingdom

Administrative contact: Renata SchaefferTel.: +44 1223 333543Fax: +44 1223 332988E-mail

EU contribution: EUR 562 461,6

"THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE" United Kingdom

QUEEN MARY UNIVERSITY OF LONDON United KingdomPage 2 of 6

Researchand Innovation

http://cordis.europa.eu/result/rcn/150332_en.htmlhttp://cordis.europa.eu/result/rcn/57380_en.htmlhttp://cordis.europa.eu/mailanon/form_en?address=T3Lrhcrro22QfVxiXdLTR27MaGG9Jx97NzyPuyrt0SM=&name=Prof.+Stewart+Colehttp://cordis.europa.eu/mailanon/form_en?address=atPmqjasDoEXq0a7D9yzG2mnaq0nLhHzGty6IDo+mv/4zvEKZ3nPlvFFe4koiKr2&name=Dr.+Tanjore+Balganeshhttp://cordis.europa.eu/mailanon/form_en?address=qJ9IpREPB//NvuqWneOsL4gWZgTRmZ9slDDCdaswcSo=&name=Prof.+Leif+Kirsebomhttp://cordis.europa.eu/mailanon/form_en?address=L32/6O/hS6vxm3kzvHdITaNci6CwzY3zoTVbwHTkxWo=&name=Dr.+Sofia+Bagginihttp://cordis.europa.eu/mailanon/form_en?address=mzdF85cOVhKVktBwKSGNKhtH9tAzuoAHSMvtOXmvM30=&name=Ms.+Renata+Schaeffer

327 MILE END ROADLONDON, United Kingdom

Administrative contact: Tanya SzendeffyTel.: +44 20 7882 7266Fax: +44 20 7882 7276E-mail

EU contribution: EUR 300 000

RUE DU DOCTEUR ROUX 25-28PARIS CEDEX 15, France

Administrative contact: Nadia KhelefTel.: +33 1 40 61 33 78Fax: +33 1 40 61 39 40E-mail

EU contribution: EUR 500 000

INSTITUT PASTEUR France

Leninsky Prospect 33MOSCOW, Russia

Administrative contact: Vadim MakarovTel.: +7 916 6408316Fax: +7 495 9542732E-mail

EU contribution: EUR 500 000

"Institution of the Russian Academy of Sciences, A.N. Bach Institute of Biochemistry of RAS" Russia

Via VIII Febbraio 2PADOVA, Italy

Administrative contact: Giovanni AbatangeloTel.: +39 049 827 2366Fax: +39 049 827 2355E-mail

EU contribution: EUR 375 000

UNIVERSITA DEGLI STUDI DI PADOVA Italy

SAFARIKOVO NAM 6BRATISLAVA 16, Slovakia

Administrative contact: Beata RajnakovaTel.: +421 2 60296 674Fax: +421 2 65429 064E-mail

EU contribution: EUR 425 000

UNIVERZITA KOMENSKEHO V BRATISLAVE Slovakia

HERMANN OTTO UTCA 15BUDAPEST, Hungary

Administrative contact: György KériTel.: +36 1 4872080Fax: +36 1 7999990E-mail

EU contribution: EUR 400 000

VICHEM CHEMIE KUTATO KFT Hungary

"Norwich Research Park, Colney"NORWICH, United Kingdom

EU contribution: EUR 400 000

JOHN INNES CENTRE United Kingdom

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http://cordis.europa.eu/mailanon/form_en?address=Tgv/TCDpNqK4oQsyFObv8Hbtv7mAUTnSK5lnvYcEgeQ=&name=Prof.+Tanya+Szendeffyhttp://cordis.europa.eu/mailanon/form_en?address=hrmMpGPnD+rZuLgVxqeOz9MQowvnlaIgEV5HxBe/NQE=&name=Ms.+Nadia+Khelefhttp://cordis.europa.eu/mailanon/form_en?address=6tgDT82pEoJrtLIuWq7A8fvHDrugpGQQSVeMrdCq3mU=&name=Dr.+Vadim+Makarovhttp://cordis.europa.eu/mailanon/form_en?address=jVm3F8G7eJ1K5w4f4zZFIL3r81fYi1OgAELBFTyYHdU=&name=Prof.+Giovanni+Abatangelohttp://cordis.europa.eu/mailanon/form_en?address=hpKG4CHrYVb5dgviBQsI05sPGp6VHiJDBHD1PCBBXWk=&name=Dr.+Beata+Rajnakovahttp://cordis.europa.eu/mailanon/form_en?address=aTXJKx8G0m4s28lZT7QXSA==&name=Prof.+György+Kéri

Administrative contact: Mary AndersonTel.: +44 1603 450244Fax: +44 1603 450045E-mail

CROSS MALLESHWARAM 18BANGALORE, India

Administrative contact: Valakunja NagarajaTel.: +91 80 2360 0668Fax: +91 80 2360 2697E-mail

EU contribution: EUR 162 000

INDIAN INSTITUTE OF SCIENCE India

"3rd Floor, West Wing, Neil Rao Tower, EPIP Whitefield 118, Road 3"BANGALORE, India

Administrative contact: Anand AnandkumarTel.: +91 80 41574744Fax: +91 80 41158733E-mail

EU contribution: EUR 250 000

CELLWORKS RESEARCH INDIA PRIVATE LIMITED India

DUOMO 6VERCELLI, Italy

Administrative contact: Carlo MuzioTel.: +39 0321 375 632Fax: +39 0321 375 621E-mail

EU contribution: EUR 350 000

UNIVERSITA DEGLI STUDI DEL PIEMONTE ORIENTALE AMEDEO AVOGADRO Italy

BAYSHORE HIGHWAY 1633 SUITE 342BURLINGAME CA, United States

Administrative contact: Sean EkinsTel.: +1 2154810159Fax: +1 6505229498E-mail

EU contribution: EUR 255 000

COLLABORATIVE DRUG DISCOVERY INC CORPORATION United States

BARRIO SARRIENA S NLEIOA, Spain

Administrative contact: Charo SánchezTel.: +34946012142Fax: +34946013550E-mail

EU contribution: EUR 250 000

UNIVERSIDAD DEL PAIS VASCO EHU UPV Spain

Strada Gherbella 294/bModena, Italy

Administrative contact: Alberto VenturelliTel.: +390592055134Fax: +390592055131E-mail

EU contribution: EUR 499 800

TYDOCK PHARMA S.r.l Italy

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http://cordis.europa.eu/mailanon/form_en?address=wLHBpxovmOcGASMqptN7l732e2p+jWVno5Mw4UgmDwM=&name=Dr.+Mary+Andersonhttp://cordis.europa.eu/mailanon/form_en?address=fwakjTLfTwJwi63iu9Xl2p3/zwccU7Nr6lKRqP4+2pY=&name=Prof.+Valakunja+Nagarajahttp://cordis.europa.eu/mailanon/form_en?address=PMJoI1UikkAcQxHwdm7kzEWb0QLbXKp2VSfCuERmQMY=&name=Dr.+Anand+Anandkumarhttp://cordis.europa.eu/mailanon/form_en?address=AjBK22miI64xHAjFm7YvOML1bW7VuOGVNX2fZp6c+Ko=&name=Dr.+Carlo+Muziohttp://cordis.europa.eu/mailanon/form_en?address=nSgBWr3gSTZgqGAfxOwpjfAY1erLP8X6XMP6VbO2+UI=&name=Dr.+Sean+Ekinshttp://cordis.europa.eu/mailanon/form_en?address=qHxQnx85tu2U2sHt1xDleJnF3ZPXJjclIy97YWCQFCc=&name=Ms.+Charo+Sánchezhttp://cordis.europa.eu/mailanon/form_en?address=VLRwM92LJiJzm+H5C0rYuocdpW8w14qVJwWM1aAY+3k=&name=Dr.+Alberto+Venturelli

CALLE PEDRO CERBUNA 12Zaragoza, Spain

Administrative contact: Jose A. AinsaTel.: +34 976 762420Fax: +34 976 762420E-mail

EU contribution: EUR 250 000

UNIVERSIDAD DE ZARAGOZA Spain

Raemistrasse 101ZUERICH, Switzerland

Administrative contact: Karl-Heinz AltmannTel.: +41446337390Fax: +41446331369E-mail

EU contribution: EUR 450 000

EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZURICH Switzerland

Loebstedter Str. 103-105Jena, Germany

Administrative contact: Albert HinnenTel.: +49 3641 3111179Fax: +49 3641 3111244E-mail

EU contribution: EUR 150 000

Alere Technologies GmbH Germany

Pierre Brossolette 1Chilly Mazarin, France

Administrative contact: Frederic GalliTel.: +331 45362261Fax: +331 45362617E-mail

EU contribution: EUR 600 000

SANOFI-AVENTIS RECHERCHE & DEVELOPPEMENT France

PRIVATE BAG X3RONDEBOSCH, South Africa

Administrative contact: Roger WallaceTel.: +27 21 650 4718Fax: +27 114899397E-mail

EU contribution: EUR 250 000

UNIVERSITY OF CAPE TOWN South Africa

RUE DU CENTRE 70Saint-Sulpice, Switzerland

Administrative contact: Iain OldTel.: +41 21 694 04 13Fax: +41 21 694 04 19E-mail

EU contribution: EUR 150 515,62

SCIPROM SARL Participation ended Switzerland

101 Rue de TolbiacPARIS, France

Administrative contact: Virginie ChameroyTel.: +33 320 29 82 29

EU contribution: EUR 450 000

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) France

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http://cordis.europa.eu/mailanon/form_en?address=gTis25Teck2TD9keluS4tw==&name=Dr.+Jose A.+Ainsahttp://cordis.europa.eu/mailanon/form_en?address=PEPUUkQ6bS9micUMDesq3OtaI78Q6T9AX3m1bWdLO12ugkDnQk4hEdge8FE/bTD1&name=Prof.+Karl-Heinz+Altmannhttp://cordis.europa.eu/mailanon/form_en?address=Hc+YI0hKmbIeHO4WY8T54l3FVYipf7vluuVd5T8SR8s=&name=Dr.+Albert+Hinnenhttp://cordis.europa.eu/mailanon/form_en?address=xa/sGiZqEwzw7fWcp7C5UHiJ6qybH8EmejYhh26cgOX4zvEKZ3nPlvFFe4koiKr2&name=Dr.+Frederic+Gallihttp://cordis.europa.eu/mailanon/form_en?address=x/JClylYEwH/RCUq7x/hYI1X8iaPeGpVAB+U/Ep7icg=&name=Dr.+Roger+Wallacehttp://cordis.europa.eu/mailanon/form_en?address=Ixbn0dbBLm/fKNdZdVkXwf7JbWuG5Ty9ik5KD9UZ4Ao=&name=Dr.+Iain+Old

Fax: +33 320 49 01 38E-mail

Subjects

Medical biotechnology

Last updated on 2015-03-10Retrieved on 2015-07-15

Permalink: http://cordis.europa.eu/project/rcn/98754_en.html© European Union, 2015

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