Wou

dsch

oute

n C

hem

ie C

onfe

rent

ie 2

012

De

mod

erne

che

mis

che

reac

tor

Van

gero

erde

pot

naa

r mul

ti-fu

nctio

neel

app

araa

t Ja

ap S

chou

ten

…..

the

next

75

min

utes

(or s

o)

� TU

Ein

dhov

en

� Fa

culte

it Sc

heik

undi

ge T

echn

olog

ie

�

Proc

este

chno

logi

e &

Rea

ctor

kund

e � …

.. a

rapi

dly

chan

ging

Wor

ld !

� D

e m

oder

ne c

hem

isch

e re

acto

r:

�

mic

rore

acto

ren

� sp

inni

ng d

isk

reac

tore

n

� D

emo

& “

Tea

Leaf

Par

adox

”

Eind

hove

n U

nive

rsity

of

Tech

nolo

gy

Jaap

Sch

oute

n N

ovem

ber 2

012

Euro

pe -

The

Net

herla

nds

- Ein

dhov

en

… a

lead

ing

posi

tion

in th

e w

orld

as

an in

tern

atio

nal

top

rese

arch

uni

vers

ity

with

a m

ajor

impa

ct in

en

gine

erin

g sc

ienc

e an

d te

chno

logy

…

Eind

hove

n U

nive

risty

of T

echn

olog

y

Bac

helo

r Col

lege

G

radu

ate

Prog

ram

Ener

gy

Hea

lth

Smar

t Mob

ility

TU/e

Str

ateg

ic R

esea

rch

Are

as:

Ene

rgy,

Hea

lth, S

mar

t Mob

ility

TU/e

Sci

ence

Par

k:

“Whe

re in

nova

tion

star

ts”,

Inno

vatio

n La

b, C

atal

yst

TU/e

& B

rain

port

202

0:

Ambi

tion

to b

e in

the

top-

3 in

202

0 of

top

tech

nolo

gy re

gion

s of

Eu

rope

and

in to

p-10

on

wor

ld le

vel

Hig

h-Te

ch C

ampu

s Ei

ndho

ven

Che

mel

ot C

ampu

s G

elee

n TU

/e c

olla

bora

tions

: FO

M In

stitu

te D

IFFE

R (e

nerg

y, p

lasm

a ph

ysic

s)

Stra

tegi

c Al

lianc

e TU

/e –

UU

(bio

med

ical

imag

ing,

sol

ar fu

els)

3T

U F

eder

atio

n (c

hem

ical

eng

inee

ring)

C

entre

of E

xcel

lenc

e TU

/e –

RU

N (c

ompl

ex m

olec

ular

sys

tem

s)

Prof

ile T

U/e

7

Dep

artm

ent o

f Che

mic

al E

ngin

eerin

g an

d C

hem

istr

y

Dep

artm

ents

M

athe

mat

ics

& In

form

atic

s A

pplie

d P

hysi

cs

Che

mic

al E

ngin

eerin

g an

d C

hem

istr

y E

lect

rical

Eng

inee

ring

Mec

hani

cal E

ngin

eerin

g B

iom

edic

al E

ngin

eerin

g In

dust

rial E

ngin

eerin

g &

Inno

vatio

n S

cien

ces

Arc

hite

ctur

e In

dust

rial D

esig

n

TU/e

Fac

ts &

Fig

ures

(201

1)

Stud

ents

: 735

8 R

esea

rch

staf

f: 20

47

Full

prof

esso

rs: 1

32

PhD

stu

dent

s: 1

205

Part

-tim

e pr

ofes

sors

: 115

Sc

ient

ific

publ

icat

ions

: 309

8

Tota

l bud

get:

317

M€

Eind

hove

n re

gion

21

mun

icip

aliti

es, p

opul

atio

n of

730

.000

384.

000

jobs

>

70.0

00 jo

bs in

indu

stry

>

50%

of w

hich

are

hig

h- &

med

ium

-tech

R&

D e

xpen

ditu

re 3

% o

f Gro

ss D

omes

tic P

rodu

ct

Sout

heas

t Net

herla

nds

acco

unts

for 5

0% o

f Dut

ch R

&D

exp

endi

ture

Reg

iona

l fac

ts T

U/e

TU

/e S

trat

egy

2020

Inte

rnat

iona

lizat

ion

of s

tude

nts

and

educ

atio

n �

Mor

e in

tern

atio

nal M

Sc, P

DEn

g an

d Ph

D s

tude

nts

�To

p ta

lent

with

an

inte

rnat

iona

l foc

us

Bac

helo

r Col

lege

& G

radu

ate

Scho

ol

Stre

ngth

enin

g in

tern

atio

nal r

esea

rch

posi

tion

Dev

elop

ing

cam

pus

into

TU

/e S

cien

ce P

ark

of

nat

iona

l im

port

ance

and

inte

rnat

iona

l sty

le

Dev

elop

inte

rnat

iona

l uni

vers

ity c

ultu

re

TU/e

Inno

vatio

n La

b �

stra

tegi

c co

llabo

ratio

n w

ith in

dust

ry

� de

velo

pmen

t of t

echn

olog

y in

nova

tion

prog

ram

s �

new

bus

ines

s de

velo

pmen

t (sp

in-o

ffs)

� en

trepr

eneu

rshi

p (te

chno

-sta

rters

) Ed

ucat

ion

Min

or E

ntre

pren

eurs

hip

& In

nova

tion

Cer

tific

ate

Tech

nolo

gy E

ntre

pren

eurs

hip

Cat

alys

t Tec

hnol

ogy

& B

usin

ess

Incu

bato

r Ein

dhov

en (4

000

m2 )

of

fices

(200

0 m

2 ), w

orks

hops

(867

m2 )

, che

mis

try la

bs (6

00 m

2 ), o

ther

labs

(533

m2 )

Kno

wle

dge

valo

risat

ion

at T

U/e

Sp

in o

ff co

mpa

nies

– C

atal

yst B

uild

ing

(201

2)

Tim

es H

ighe

r Edu

catio

n R

anki

ng 2

011-

2012

� 6

8 U

U

� 7

5 W

UR

�

79

LU

� 9

2 U

vA

� 10

4 TU

D

� 11

5 TU

/e

� 13

4 R

UG

�

157

EU

R

� 15

9 V

U

� 19

7 M

U

� 20

0 U

T

THE

Ran

king

200

Top

Uni

vers

ities

201

1-20

12 U

SA

75

Bel

gium

3

U

K

32

Kor

ea

3

G

erm

any

12

Sing

apor

e 2

N

ethe

rland

s

11

Ire

land

2

C

anad

a 9

Nor

way

2

A

ustr

alia

7

Isra

el

2

Sw

itzer

land

7

Taiw

an

1

Fran

ce

6

So

uth

Afr

ica

1

Japa

n

5

A

ustr

ia

1

Swed

en

5

B

razi

l

1

Hon

g K

ong

4

Fi

nlan

d 1

C

hina

3

Sp

ain

1

D

enm

ark

3

Else

vier

-ond

erzo

ek S

epte

mbe

r 201

2

…..

the

next

min

utes

(or s

o)

� TU

Ein

dhov

en

� Fa

culte

it Sc

heik

undi

ge T

echn

olog

ie

�

Proc

este

chno

logi

e &

Rea

ctor

kund

e � …

.. a

rapi

dly

chan

ging

Wor

ld !

� D

e m

oder

ne c

hem

isch

e re

acto

r:

�

mic

rore

acto

ren

� sp

inni

ng d

isk

reac

tore

n

� D

emo

& “

Tea

Leaf

Par

adox

”

Dep

artm

ent o

f Che

mic

al E

ngin

eerin

g an

d C

hem

istr

y

Fact

s &

Fig

ures

Staf

f: 13

pr

ofes

sors

8

as

soci

ate

prof

esso

rs

20

assi

stan

t pro

fess

ors

76

tech

nica

l/adm

inis

trat

ive

supp

ort s

taff

Stud

ents

: B

Sc

MSc

Ph

D

PDEn

g (in

201

1)

259

199

183

38

Bud

get 2

012:

30

MEu

ro (i

ncl.

16 M

euro

ext

erna

l fun

ding

) Pu

blic

atie

s in

refe

reed

sci

entif

ic jo

urna

ls:

2008

: 246

; 200

9: 2

90; 2

010:

267

; 201

1: 2

32

Dep

artm

ent o

f Che

mic

al E

ngin

eerin

g an

d C

hem

istr

y D

epar

tmen

t of C

hem

ical

Eng

inee

ring

and

Che

mis

try

Stud

ent i

ntak

e:

BS

c:

60

– 8

0 st

uden

ts/y

ear

MS

c:

45 –

65 s

tude

nts/

year

P

hD:

35

– 4

5 st

uden

ts/y

ear

P

DE

ng:

20 –

25

stud

ents

/yea

r

Out

flow

mor

e th

an 1

00 s

tude

nts/

year

:

5

0 –

60 M

Sc/

year

30

– 40

PhD

/yea

r

20

– 2

5 P

DE

ng/y

ear

Tops

ecto

ren:

Mas

terp

lan

Bèt

a en

Tec

hnol

ogie

V

MB

O

M

BO

HB

O

W

O

T

otaa

l To

taal

inst

room

19

3.70

0 62

3.80

0 32

8.50

0 18

3.50

0

1.32

9.50

0 ar

beid

smar

kt

Tota

al b

èta

&

6

3.10

0 18

7.30

0 5

4.30

0 3

2.70

0

33

7.40

0 te

chno

logi

e %

tech

nisc

h

33%

30%

17%

18%

25%

ge

dipl

omee

rden

P

rogn

ose

inst

room

201

1-20

16

Mee

r tec

hnol

ogie

tale

nt v

oor N

eder

land

Doe

lste

lling

202

5: 4

0%

Imag

o –

Wer

ving

Af

stem

min

g ar

beid

smar

kt –

Soc

iale

inno

vatie

In

tern

atio

nalis

erin

g

Die

Zei

t – S

tudi

enfu

ehre

r – C

HE

Ran

king

Res

earc

h Fo

cal A

reas

Mol

ecul

ar S

yste

ms

an

d M

ater

ials

Che

mis

try

Che

mic

al

and

Pr

oces

s Te

chno

logy

Dep

artm

ent o

f Che

mic

al E

ngin

eerin

g an

d C

hem

istr

y

Mol

ecul

ar S

yste

ms

and

Mat

eria

ls C

hem

istr

y M

acro

-Org

anic

Che

mis

try

Pr

of. B

ert M

eije

r M

olec

ular

Mat

eria

ls a

nd N

anos

yste

ms

Prof

. Ren

é Ja

nsse

n Su

pram

olec

ular

Pol

ymer

Che

mis

try

Prof

. Rin

t Sijb

esm

a Fu

ncti

onal

Mat

eria

ls a

nd D

evic

es

Prof

. Dic

k Br

oer

Mat

eria

ls a

nd In

terf

ace

Chem

istr

y

Pr

of. B

ert d

e W

ith

Poly

mer

Mat

eria

ls

Va

canc

y Ch

emic

al a

nd P

roce

ss T

echn

olog

y Ch

emic

al R

eact

or E

ngin

eeri

ng

Prof

. Jaa

p Sc

hout

en

Mul

tisc

ale

Mod

ellin

g of

Mul

tiph

ase

Flow

s

Prof

. Han

s Ku

iper

s M

icro

Flo

w C

hem

istr

y &

Pro

cess

Tec

hnol

ogy

Pr

of. V

olke

r H

esse

l Po

lym

er R

eact

ion

Engi

neer

ing

Prof

. Jan

Meu

ldijk

M

olec

ular

Het

erog

eneo

us C

atal

ysis

Prof

. Em

iel H

ense

n Ch

emic

al P

roce

ss In

tens

ifica

tion

Pr

of. M

arti

n va

n Si

nt A

nnal

and

Sepa

rati

on T

echn

olog

y

Prof

. Maa

ike

Kroo

n

Exci

ting

rese

arch

the

mes

: �

com

plex

mol

ecul

es

� m

acro

-mol

ecul

ar a

ssem

blie

s

� m

ater

ials

with

spe

cial

func

tiona

litie

s � su

pram

olec

ular

arc

hite

ctur

es a

nd o

rgan

ic m

ater

ials

for e

lect

roni

cs

� st

ruct

ure

and

func

tiona

l per

form

ance

of m

ulti-

mat

eria

ls

� co

ntro

l of m

olec

ular

and

mat

eria

l str

uctu

res

and

mor

phol

ogy

� in

terf

acia

l phe

nom

ena

and

mul

ti-m

ater

ials

� no

vel m

olec

ular

con

cept

s in

pol

ymer

, mat

eria

ls a

nd o

rgan

ic c

hem

istr

y � ad

vanc

ed n

ew m

ater

ials

: con

duct

ing

poly

mer

s, s

olar

cel

ls, d

ispl

ays

� an

d m

any

mor

e …

…

Mol

ecul

ar S

yste

ms

and

Mat

eria

ls C

hem

istr

y

Exci

ting

rese

arch

the

mes

: �

com

plex

mul

ti-ph

ase

flow

s

� m

ulti-

scal

e CF

D m

odel

ing

� pr

oces

s in

tens

ifica

tion

� no

vel r

eact

ors

� hi

gh-s

hear

& h

igh-

grav

ity s

yste

ms

� m

icro

-str

uctu

red

reac

tors

� flo

w c

hem

istr

y

� ad

vanc

ed s

epar

atio

n sy

stem

s

� em

ulsi

on p

olym

eriz

atio

n

� ca

taly

sis

engi

neer

ing

� pr

oces

s sy

stem

s en

gine

erin

g

� an

d m

any

mor

e …

…

Che

mic

al a

nd P

roce

ss T

echn

olog

y

Spin

-off

com

pani

es a

t dep

artm

ent C

EC

Mai

n st

rate

gic

rese

arch

par

tner

s

Publ

ic-P

riva

te P

artn

ersh

ips:

D

utch

Pol

ymer

Inst

itute

(DPI

) In

stitu

te fo

r Su

stai

nabl

e Pr

oces

s Te

chno

logy

(ISP

T)

Aca

dem

ic P

artn

ersh

ips:

D

elft

and

Tw

ente

Uni

vers

ities

of T

echn

olog

y (3

TU)

Uni

vers

ities

of U

trec

ht a

nd N

ijmeg

en

FOM

Ene

rgy

Inst

itute

DIF

FER

Indu

stri

al P

artn

ersh

ips:

D

SM, A

kzoN

obel

, She

ll, P

hilip

s, A

lfaLa

val,

MSD

, Evo

nik,

BA

SF,

and

man

y m

ore

indu

stri

al (c

hem

ical

) com

pani

es

…..

the

next

min

utes

(or s

o)

� TU

Ein

dhov

en

� Fa

culte

it Sc

heik

undi

ge T

echn

olog

ie

�

Proc

este

chno

logi

e &

Rea

ctor

kund

e � …

.. a

rapi

dly

chan

ging

Wor

ld !

� D

e m

oder

ne c

hem

isch

e re

acto

r:

�

mic

rore

acto

ren

� sp

inni

ng d

isk

reac

tore

n

� D

emo

& “

Tea

Leaf

Par

adox

”

“Pro

cest

echn

olog

ie”

Fy

sisc

he C

hem

ie

Ther

mod

ynam

ica

Stro

min

gsle

er

Fysi

sche

Tra

nspo

rtve

rsch

ijnse

len

Stof

- en

War

mte

over

drac

ht

Rea

ctie

kine

tiek

& K

atal

yse

Che

mis

che

Rea

ctor

tech

nolo

gie

Sche

idin

gste

chno

logi

e Pr

oces

- en

Prod

ucto

ntw

erp

Proc

esdy

nam

ica

Proc

esre

gelin

g Pr

oces

s Sy

stem

s En

gine

erin

g Te

chni

sche

Bed

rijfs

kund

e Te

chno

logi

e M

anag

emen

t

Che

mic

al a

nd P

roce

ss T

echn

olog

y

Che

mic

al R

eact

or –

Its

Fun

ctio

ns

… e

nabl

es th

e

nece

ssar

y re

actio

n tim

e

… re

mov

es o

r ad

ds h

eat

… p

rovi

des

phas

e in

terf

aces

Stir

red

Tan

k R

eact

or

Slu

rry

Bu

bble

Col

um

n

Gas

Li

quid

So

lid

Rea

ctor

s

Geo

rgii

Agr

icol

ae

De

Re

Met

allic

a, 1

55

6

(Ada

pted

fro

m A

. Sta

nki

ewic

z, T

U D

elft

)

Proc

ess

& R

eact

or In

tens

ifica

tion

…..

the

next

min

utes

(or s

o)

� TU

Ein

dhov

en

� Fa

culte

it Sc

heik

undi

ge T

echn

olog

ie

�

Proc

este

chno

logi

e &

Rea

ctor

kund

e � …

.. a

rapi

dly

chan

ging

Wor

ld !

� D

e m

oder

ne c

hem

isch

e re

acto

r:

�

mic

rore

acto

ren

� sp

inni

ng d

isk

reac

tore

n

� D

emo

& “

Tea

Leaf

Par

adox

”

�Su

stai

nabi

lity

& C

radl

e-to

-Cra

dle

� C

O2

& C

limat

e C

hang

e � R

esou

rces

& B

ioba

sed

Econ

omy

� En

ergy

, Wat

er, H

ealth

& M

obili

ty

� Ec

onom

ic G

row

th &

Em

ploy

men

t �Ed

ucat

ion

& E

xcel

lenc

e � O

pen

Inno

vatio

n &

Res

earc

h � G

loba

lisat

ion

& W

ar fo

r Tal

ent

…..

a ra

pidl

y ch

angi

ng w

orld

! K

ey J

ourn

als

Che

mic

al E

ngin

eerin

g

Jour

nal

#

Pape

rs

Shar

e

# Pa

pers

: art

icle

s &

revi

ews,

195

1 –

2011

Indu

stri

al E

ngin

eeri

ng C

hem

istr

y Re

sear

ch (I

ECR)

183

05

31.2

%

Chem

ical

Eng

inee

ring

Sci

ence

(CES

)

163

40

27.9

%

AIC

hE Jo

urna

l (A

IChE

J)

103

36

17.6

%

Chem

ical

Eng

inee

ring

Jour

nal (

CEJ)

5

234

8

.9%

Chem

ical

Eng

inee

ring

Res

earc

h D

esig

n (C

ERD

)

311

3

5.3

%

Chem

ical

Eng

iner

ing

Tech

nolo

gy (C

ET)

301

3

5.1

%

Chem

ical

Eng

inee

ring

Pro

cess

ing

(CEP

)

2

339

4

.0%

Tota

l

586

89

100

%

Key

Cou

ntrie

s C

hem

ical

Eng

inee

ring

Peri

od:

1951

– 2

011

20

02 –

201

1

2008

– 2

011

Pape

rs:

5868

9

2950

5

14

542

Shar

e:

100

%

50

.3%

24.8

%

Top

10 c

ount

ries

U

SA

1495

1

U

SA

562

0

CHIN

A

268

2 CH

INA

4

472

CHIN

A

393

0

USA

2

312

ENG

L 3

801

GER

M

224

3

IND

IA

108

7 G

ERM

3

566

IND

IA

198

2

GER

M

9

46

CAN

3

016

ENG

L 1

753

SP

AIN

803

IN

DIA

2

874

CAN

1

607

FR

AN

CE

778

FR

AN

CE

2650

FR

AN

CE

1601

CAN

754

JA

PAN

2

306

SPA

IN

149

5

ENG

L

675

SP

AIN

2

078

JAPA

N

120

5

JAPA

N

5

17

NL

200

3

N

L

984

IRA

N

4

57

Tota

l 41

717

(71%

)

Tota

l 22

420

(76%

) To

tal

1101

1 (7

6%)

Mos

t Cite

d Pa

pers

200

8 –

2011

1.Pr

etre

atm

ent

of b

iom

ass

and

biof

uel p

rodu

ctio

n, IE

CR (2

009)

, #19

2

2.D

iscr

ete

part

icle

sim

ulat

ion,

IECR

(200

8), #

111

3.CO

2 se

para

tion

in io

nic

liqui

ds, I

ECR

(200

8), #

110

4.Ch

emic

al lo

opin

g co

mbu

stio

n an

d CO

2 se

para

tion

, CES

(200

9), #

106

5.M

odel

ing

of a

dsor

ptio

n an

d tr

ansp

ort i

n M

OF

mat

eria

ls, I

ECR

(200

9), #

101

6.H

ydro

gen

prod

ucti

on fr

om b

iom

ass

and

CO2

capt

ure,

CES

(200

8), #

100

7.So

rpti

on-e

nhan

ced

hydr

ogen

pro

duct

ion,

IECR

(200

8), #

86

8.M

odel

ing

of d

iffus

ion

and

reac

tion

in a

por

ous

cata

lyst

, CEJ

(200

8), #

82

9.M

embr

ange

gas

sep

arat

ion,

IECR

(200

9), #

81

10.M

esop

orou

s si

lica

for

drug

del

iver

y, C

EJ (2

008)

, #78

� CH

INA

obt

aine

d to

p-1

posi

tion

larg

est n

umbe

rs o

f pap

ers

� EN

GL

drop

ped

out o

f top

-5 ra

nkin

g �

IND

IA fi

rm p

osit

ion

in to

p-5

rank

ing

larg

est n

umbe

rs o

f pap

ers

� U

SA h

ighe

st im

pact

(num

ber

of c

itat

ions

per

pap

er)

Reg

iona

l Im

pact

on

Che

mic

al E

ngin

eerin

g

1971

-198

0 19

81-1

990

1991

-200

0 20

01-2

010

2007

-201

1

USA

40

.7

USA

29

.6

USA

25

.9

USA

13

.7

CHIN

A

4.5

ENG

L 29

.8

ENG

L 24

.4

ENG

L 19

.7

CHIN

A

8.6

U

SA

6.1

CAN

34

.0

CAN

28

.9

GER

M

16.1

G

ERM

11

.1

IND

IA

5.5

JAPA

N

29.3

JA

PAN

20

.8

CAN

21

.4

IND

IA

10.4

G

ERM

4.

9 IN

DIA

21

.3

FRG

25

.7

FRA

NCE

18

.1

ENG

L 11

.5

SPA

IN

6.1

(NL

25.2

N

L 27

.0

NL

25.2

N

L 13

.4

NL

6.8)

Top-

5 ra

nkin

g la

rges

t num

ber

of p

aper

s A

vera

ge n

umbe

r of

cit

atio

ns p

er p

aper

Reg

iona

l Im

pact

on

Scie

nce

& T

echn

olog

y

Peri

od:

Jan

2002

– F

eb 2

012

CHEM

ISTR

Y

PHYS

ICS

#pap

ers

#c

itat

ions

/pap

er

#p

aper

s

#cit

atio

ns/p

aper

U

SA

2272

77

USA

20

.93

U

SA

2154

16

SWIT

Z 14

.33

CHIN

A

2099

33

NL

18.2

3

CHIN

A

1392

85

NL

13.9

4 JA

PAN

10

8603

SW

ITZ

17.6

7

JAPA

N

1080

08

AU

STRI

A 1

3.27

G

ERM

9

5023

D

ENM

15

.69

G

ERM

10

1656

U

SA

12.9

8 IN

DIA

7

0188

EN

GL

15.0

1

FRA

NCE

7

3266

SC

OTL

12

.89

ENG

INEE

RIN

G

MAT

ERIA

LS S

CIEN

CE

#p

aper

s

#cit

atio

ns/p

aper

#pap

ers

#c

itat

ions

/pap

er

USA

20

2149

SW

ITZ

7.21

CHIN

A

1015

46

NL

13.4

2 CH

INA

10

2848

D

ENM

7.

17

U

SA

738

09

DEN

M

13.0

0 JA

PAN

6

1334

BE

LG

6.40

JAPA

N

494

77

USA

12

.57

ENG

L 4

7586

U

SA

6.33

GER

M

332

55

SWIT

Z 12

.57

GER

M

465

57

NL

6.17

STH

KO

R

2905

0 SC

OTL

12

.04

Reg

iona

l Im

pact

on

Scie

nce

& T

echn

olog

y

Peri

od:

Jan

2002

– F

eb 2

012

ENV

IRO

NM

ENT/

ECO

LOG

Y

BIO

LOG

Y/BI

OCH

EMIS

TRY

#pap

ers

#c

itat

ions

/pap

er

#p

aper

s

#cit

atio

ns/p

aper

U

SA

8941

5 SW

ITZ

17.3

9

USA

19

0727

SW

ITZ

23.7

7 CH

INA

22

525

SWED

EN 1

6.25

JAPA

N

553

35

USA

22

.30

CAN

20

423

ENG

L 16

.04

G

ERM

4

2964

SC

OTL

21

.56

ENG

L 18

796

SCO

TL

15.6

5

ENG

L 3

7871

EN

GL

21.3

7 G

ERM

17

694

NL

15.2

1

CHIN

A

367

22

DEN

M

19.3

4 M

ICRO

BIO

LOG

Y

PH

ARM

ACO

LOG

Y/TO

XICO

LOG

Y #p

aper

s

#cit

atio

ns/p

aper

#pap

ers

#c

itat

ions

/pap

er

CHIN

A

1015

46

NL

13.4

2

USA

54

069

SCO

TL

20.3

6

USA

7

3809

D

ENM

13

.00

JA

PAN

20

034

SWIT

Z 16

.65

JAPA

N

494

77

USA

12

.57

CH

INA

15

693

ENG

L 16

.12

GER

M

332

55

SWIT

Z 12

.57

G

ERM

12

580

USA

15

.91

STH

KO

R

2905

0 SC

OTL

12

.04

EN

GL

1139

2 SW

EDEN

15.

57

…..

the

next

min

utes

(or s

o)

� TU

Ein

dhov

en

� Fa

culte

it Sc

heik

undi

ge T

echn

olog

ie

�

Proc

este

chno

logi

e &

Rea

ctor

kund

e � …

.. a

rapi

dly

chan

ging

Wor

ld !

� D

e m

oder

ne c

hem

isch

e re

acto

r:

�

mic

rore

acto

ren

� sp

inni

ng d

isk

reac

tore

n

� D

emo

& “

Tea

Leaf

Par

adox

”

Geo

rgii

Agr

icol

ae

De

Re

Met

allic

a, 1

55

6

(Ada

pted

fro

m A

. Sta

nki

ewic

z, T

U D

elft

)

Proc

ess

& R

eact

or In

tens

ifica

tion

From

Bat

ch to

Con

tinuo

us P

roce

ssin

g

Con

tinuo

us p

roce

ssin

g � B

ulk

& P

etro

chem

ical

indu

stry

� S

ingl

e pu

rpos

e se

t-up

� S

ame

chem

istry

in s

ame

reac

tor

� Aut

omat

ed o

pera

tion

� Eur

os /

ton

prod

uced

� >

> 90

% y

ield

� O

pen

air f

acili

ties

Bat

ch p

roce

ssin

g � F

ine-

chem

ical

s &

Pha

rmac

eutic

als

� M

ulti-

purp

ose

set-u

p � D

iffer

ent p

rodu

cts

in s

ame

reac

tor

� Sem

i-aut

omat

ed o

pera

tion

� > 1

000

Eur

os /

gram

pro

duct

� 2

-3 %

yie

ld; 4

kg

was

te /

kg p

rodu

ct

� Clo

sed

build

ings

Gas

-Liq

uid-

Solid

Rea

ctio

n Pr

oces

ses

a gl

a s

Cg

CB

Gas

Li

quid

So

lid

Gas

Li

quid

So

lid

Ag

ggl

lgl

ss

tr

HH

Hr

Cka

ka

ka

mLk

�

��

��

��

��

�

�

�

11

Reaction rate

Cat

alys

t con

cent

ratio

n

… m

ass

tran

sfer

li

mite

d

… k

inet

ical

ly

lim

ited

Ag

ggl

lgl

ss

tr

HH

Hr

Cka

ka

ka

mLk

�

��

��

��

��

�

�

�

11

Ag

ggl

lgl

ss

tr

HH

Hr

Cka

ka

ka

mLk

�

��

��

��

��

�

�

�

11

Min

i & M

icro

Flo

w S

yste

ms

Hyd

rody

nam

ics

and

Tran

spor

t

mic

roch

anne

ls

mac

ropo

res

mic

ropo

res

clus

ters

re

acto

r pla

tes

10-3

10

-4

10-5

10

-6

10-7

10

-8

10-9

m

Kin

etic

s an

d C

atal

ytic

Act

ivity

Ato

mic

sca

le: a

ppro

pria

te c

atal

yst w

ith m

eso/

mic

ro p

ore

syst

em

Nan

o sc

ale:

met

allic

clu

ster

s, n

arro

w p

artic

le s

ize

dist

ribut

ion,

des

ired

met

al lo

adin

gs

Mic

ro s

cale

: thi

n ca

taly

st la

yer

to a

void

long

diff

usio

n pa

thw

ays

in m

acro

pore

s M

acro

sca

le: s

ame

resi

denc

e tim

e an

d re

actio

n co

nditi

ons

in e

very

(mic

ro)c

hann

el

Para

digm

: Ful

l Con

trol

at M

ultip

le L

engt

h Sc

ales

(M

icro

) Rea

ctor

Map

ping

Poly

mer

Inte

rmed

iate

Pro

duct

ion

Met

hane

Ref

orm

ing

in a

Mic

ro R

eact

or

Met

hane

Ref

orm

ing

in a

Mic

ro R

eact

or

Met

hane

Ref

orm

ing

in a

Mic

ro R

eact

or

Met

hane

Ref

orm

ing

in a

Mic

ro R

eact

or

Gas

-Liq

uid-

Liqu

id F

low

in a

Mic

ro C

hann

el

Out

let

Dec

ane

N2

Wat

er

Dec

ane

Inte

rmitt

ent –

inte

rmitt

ent f

low

Th

ree-

phas

e sl

ug fl

ow

Wat

er

N2

Wat

er

Para

llel –

inte

rmitt

ent f

low

N2

Dec

ane

W

HW

= 3

00 �

m, H

= 6

0 �m

Tran

sitio

nal f

low

pat

tern

Dec

ane

Wat

er

N2

Ch

arac

teri

stic

fea

ture

s:

� ch

anne

l dim

ensi

ons

100-

1000

�m

�

shor

t di

ffus

ion

leng

ths

� ex

celle

nt h

eat

& m

ass

tran

sfer

�

cata

lytic

ally

act

ive

supp

ort

stru

ctur

es

� ca

rbon

nan

ofib

ers

to e

nlar

ge s

urfa

ce a

rea

�

high

rea

ctio

n ra

tes

Pilla

red

Cat

alyt

ic M

icro

Rea

ctor

s

“Str

uct

ure

d M

icro

Rea

ctor

s”

Larg

e P

itch

C

lass

ic F

low

Map

UL

= 0

.1 m

s-1

UG =

0.2

7 m

s-1

UL

= 0

.52

m s

-1 U

G =

0.3

2 m

s-1

UL

= 0

.15

m s

-1 U

G =

1.2

m s

-1

UL

= 0

.2 m

s-1

UG =

5.9

m s

-1

UL

= 0

.3 m

s-1

UG =

4.1

m s

-1

UL

= 0

.1 m

s-1

UG =

22

.9 m

s-1

Smal

l Pit

ch

On

ly T

rick

le F

low

7 �

m

17

�m

50

�m

2 �

m

3 μm

50 μ

m 1

mm

x 5

0 μm

x 6

6 m

m

Ch

arac

teri

stic

fea

ture

s:

� m

icro

chan

nel w

ith 2

50 �

m d

iam

eter

�

gas-

liqui

d-so

lid in

terf

aces

�

nano

stru

ctur

ed fi

lms

as s

uppo

rt

� co

lloid

s-de

rived

act

ive

nano

part

icle

s �

exce

llent

hea

t &

mas

s tr

ansf

er

� be

tter

yie

ld a

nd s

elec

tivity

Mic

ro C

apill

ary

Che

mic

als

Synt

hesi

s

1 mm

Liqu

id

Liqu

id

Gas

Dop

ing

with

Pt 50

Sn50

co

lloid

s

Gen

tle A

ctiv

atio

nP

t 50S

n 50

Nan

ostr

uctu

red

activ

e fil

ms

Coa

ted

fuse

d si

lica

capi

llary

con

tain

ing

a Pd

Zn /

TiO

2 thi

n fil

m w

ith a

cub

ic m

esos

truc

ture

Zn

Pd

Fuse

d si

lica

TiO

2

TiO

2

Fuse

d si

lica

Fuse

d si

lica

TiO

2

TiO

2

Fuse

d si

lica

A. A

ota

et a

l., A

ngew

. Che

m. I

nt. E

d. 4

6 (2

007)

878

–88

0

Sepa

ratio

n in

Mic

ro C

hann

els

� H

igh

rat

es o

f m

ass

tran

sfer

�

Hig

h s

epar

atio

n e

ffic

ien

cy

Gas

-Liq

uid

Extr

actio

n in

a M

icro

Cha

nnel

Liqu

id: A

queo

us a

min

es

Gas

: CO

2 in

nitr

ogen

P G –

P L

��

Pc

P L

P G

P C

Perf

orat

ed W

all S

epar

ator

100 �m

25 �

m

5 �m

25

�m

25 �

m

Stab

le o

pera

tion

250

�m

Emul

sion

�

k la =

1.5

– 2

.5 s

-1 1)

�

diffi

cult

sepa

ratio

n of

pha

ses

�hi

gh e

nerg

y di

ssip

atio

n

Tayl

or fl

ow

�k la

= 0

.1 –

0.5

s-1

1)

�ea

sy s

epar

atio

n of

pha

ses

�lo

w e

nerg

y di

ssip

atio

n

Flow

: 5 m

l/min

Tu

bing

ID: 2

50 �

m

Effic

ienc

y: 9

5 %

Vo

lum

e: 7

or 3

2 �l

1) K

ashi

d et

al.,

Ind.

Eng

. Che

m. R

es. (

2011

)

Dis

pers

ed F

low

Ext

ract

ion

in a

Mic

ro C

hann

el

0

0.2

0.4

0.6

0.81

020

040

060

080

010

0012

00

extraction efficiency (-)tu

bing

leng

th (m

m)

k la

= 2.

5 s-

1

k la

= 0.

5 s-

1

250

�m

Mem

bran

e se

para

tor 1

)

�0.

5 �m

por

e P

TFE

mem

bran

e �

Are

a: 1

x 2

1 m

m

�Fl

ow ra

te: 0

.01

– 2

ml/m

in

Y-ju

nctio

n se

para

tor 2

)

�O

utle

ts: s

teel

and

Tef

lon

�ID

= 1

mm

�

30%

bre

ak th

roug

h at

1 m

l/min

1)

Kra

lj et

al.,

Lab

on

a C

hip

(200

7)

2) K

ashi

d et

al.,

Ind.

Eng

. Che

m. R

es. (

2007

)

Slow

Ext

ract

ion:

Sep

arat

ion

of P

hase

s

Flow

rate

reac

tion

mix

ture

: 0.0

5-0.

1 m

l/min

Fl

ow ra

te c

oola

nt:

2

5 m

l/min

Ap

plie

d po

wer

:

~ 5

0 W

MW

Mic

row

ave–

Hea

ted

Mill

i–R

eact

or

62

1 35

4

7

Seco

nd G

ener

atio

n “h

igh-

g” S

yste

ms

GLS

Pro

cess

Inte

nsifi

catio

n

a gl

a s

Cg

CB

Gas

Li

quid

So

lid

Gas

Li

quid

So

lid

Ag

ggl

lgl

ss

tr

HH

Hr

Cka

ka

ka

mLk

�

��

��

��

��

�

�

�

11

Reaction rate

Cat

alys

t con

cent

ratio

n

… m

ass

tran

sfer

li

mite

d

… k

inet

ical

ly

lim

ited

Ag

ggl

lgl

ss

tr

HH

Hr

Cka

ka

ka

mLk

�

��

��

��

��

�

�

�

11

Ag

ggl

lgl

ss

tr

HH

Hr

Cka

ka

ka

mLk

�

��

��

��

��

�

�

�

11

� O

pen-

celle

d re

ticul

ated

mat

eria

l �

Uni

form

and

isot

ropi

c �

Inte

rcon

nect

ing

pore

s

� 1

0 –

100

pore

s pe

r lin

ear i

nch

(ppi

) �

Wel

l-def

ined

por

e si

zes:

0.2

5 –

5 m

m

� H

igh

void

age:

88

– 97

%

� H

igh

geom

etric

sur

face

are

a: 1

03 –

104

m2 /m

3 �

Any

sha

pe p

ossi

ble

� C

arbo

n, m

etal

, cer

amic

s, p

last

ic

� C

omm

erci

ally

ava

ilabl

e

Wha

t is

a So

lid F

oam

?

Foam

geo

met

rical

ly

repr

esen

ted

by a

n so

-cal

led

inte

rlink

ed

tetr

akai

deca

hedr

a

(Fou

rie, 2

002)

20 p

pi

10 p

pi

45 p

pi

100

ppi

1 cm

Wha

t is

a H

airy

Foa

m ?

100

ppi

10 p

pi

1 cm

Por

ous

pack

ed b

ed

Inve

rse

pack

ed b

ed

Hai

ry F

oam

re

duce

d 10

0 �m

CN

i(NO

3)2=

5 g N

i/gfo

am; t

oxid

atio

n=60

min

; tde

posi

tion=

30 m

in

S7

SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS77777777777777777777777777777777777777777777777777777777777777777777

Hai

ry F

oam

5 �m

10

�m

100 �m

500

o C:

smal

l thi

n fib

ers

30-9

0 nm

ca

. 3 �

m

thic

k lo

ng fi

bers

40

-160

0 nm

12

-75 �m

100 �m

10

0 �m

10

0 �m

ni

ckel

cov

ered

500

C

700

C

Exam

ples

of C

arbo

n N

ano

Fibe

rs

I-Tric

kle

III-P

ulse

II-

Bub

ble

G

L

Cou

nter

-cur

rent

flow

�

Larg

e co

ncen

tratio

n gr

adie

nts

�H

igh

gas-

liqui

d m

ass

trans

fer

�

Flow

lim

ited

by fl

oodi

ng

G

L

Co-

curr

ent u

p-flo

w

�H

igh

flow

rate

s ac

hiev

able

�

No

flood

ing

�H

igh

gas-

liqui

d m

ass

trans

fer

�In

tens

e m

ixin

g

III-P

ulse

II-

Bub

ble

Floo

ding

Poi

nts

II- B

ubbl

e

III-P

ulse

I-Tric

kle

Coc

urre

nt U

p

Cou

nter

curr

ent

Coc

urre

nt D

own

Incr

easi

ng

liqui

d ve

loci

ty

Incr

easi

ng

liqui

d ve

loci

ty

Solid

Foa

m R

eact

or: F

low

Reg

imes

Mas

s tr

ansf

er c

oeff

icie

nt

can

be r

elat

ed t

o th

e en

ergy

dis

sipa

ted

in t

he li

quid

pha

se,

calc

ulat

ed w

ith e

ither

the

fri

ctio

nal

or

tota

l pre

ssu

re d

rop

Foam

Tric

kle

bed

Mic

rore

acto

rs

Pac

ked

bed

M

onol

ith

… E

ner

gy s

avin

g

Solid

Foa

m R

eact

or: M

ass

Tran

sfer

Con

vent

iona

l Spi

nnin

g D

isc

Rea

ctor

Thi

n liq

uid

film

(��0

.30

– 0.

01 m

m)

e

.g. B

urns

et a

l., C

hem

. Eng

. Sci

. 200

3, 5

8, 2

245-

2253

Nar

row

resi

denc

e tim

e di

strib

utio

n

e.g.

Boo

dhoo

et a

l., B

HR

Gro

up C

onf.

Serie

s Pu

bl.,

19

97, 2

8, 1

25-1

33

Sur

face

wav

es in

crea

se g

as-li

quid

m

ass

tran

sfer

e.g.

Aou

ne &

Ram

shaw

, Int

. J. H

eat M

ass

Tran

sfer

,

1999

, 42,

254

3-25

56.

Hea

t tra

nsfe

r

e.g.

Woo

d et

al.,

Tra

ns. I

nst.

Che

m. E

ng.,

1973

, 51,

315

-322

68

Dis

c di

amet

er: 2

7 cm

Rot

or-s

tato

r gap

: 5 m

m

R

otat

iona

l dis

c sp

eed:

26

rad

s-1

G

as fl

ow ra

te:

7.3

10-

6 m3 s

-1

“Hig

h-g”

Spi

nnin

g D

isc

Syst

ems

69

Dis

c di

amet

er: 2

7 cm

Rot

or-s

tato

r gap

: 1 m

m

R

otat

iona

l dis

c sp

eed:

20

9 ra

d s-

1

G

as fl

ow ra

te:

7.3

10-6

m3 s

-1

5 cm

“Hig

h-g”

Spi

nnin

g D

isc

Syst

ems

Rot

or –

Sta

tor S

pinn

ing

Dis

c R

eact

or

Liqu

id fl

ow o

nly

II

I II

I

IV

35 rp

m; s

low

ed d

own

fact

or 4

10

00 rp

m; s

low

ed d

own

fact

or 1

20

Rot

or –

Sta

tor S

pinn

ing

Dis

c R

eact

or

v r

v �

Gas

bub

bles

det

ach

from

gas

inle

t due

to s

hear

: In

crea

se in

gas

-liqu

id in

terf

acia

l are

a a G

L

Hig

h ra

te o

f ren

ewal

of l

iqui

d at

bub

ble

inte

rfac

e:

Incr

ease

in m

ass

tran

sfer

coe

ffici

ent k

L

Rot

or –

Sta

tor S

pinn

ing

Dis

c R

eact

or

dis

c ro

tatio

nal s

peed

: 150

0 rp

m; g

as fl

ow ra

te: 5

00 m

l/min

mov

ies

slow

ed d

own

fact

or 1

20

1 ga

s in

let

8 ga

s in

lets

Rot

or –

Sta

tor S

pinn

ing

Dis

c R

eact

or

Li

quid

film

mas

s tr

ansf

er

�

Bub

bles

larg

er th

an ro

tor-

stat

or

dist

ance

�M

ass

tran

sfer

thro

ugh

liqui

d fil

m, c

onta

ct ti

me

dete

rmin

es

mas

s tr

ansf

er c

oeffi

cien

t:

Tur

bule

nt s

urfa

ce re

new

al

�

Bub

bles

sm

alle

r tha

n ro

tor-

stat

or d

ista

nce

�

Mas

s tr

ansf

er d

ue to

turb

ulen

t ed

dies

:

GL

b

kd�

�

112

111

163

164

11

724

424

DG

Ld

R

Rk

Eh

Vh

��

��

�

Rot

or –

Sta

tor S

pinn

ing

Dis

c R

eact

or

RD =

0.1

35 m

, h =

1 m

m

Rot

or –

Sta

tor S

pinn

ing

Dis

c R

eact

or

R

D =

0.1

35 m

�

< 7

0 ra

d s-

1

Onl

y “l

arge

” bu

bble

s

�

> 1

10 ra

d s-

1

Onl

y “s

mal

l” b

ubbl

es

Gas

-liqu

id m

ass

tran

sfer

incr

ease

s w

ith d

ecre

asin

g

ro

tor-

stat

or d

ista

nce

Rot

or –

Sta

tor S

pinn

ing

Dis

c R

eact

or

Rot

or –

Sta

tor S

pinn

ing

Dis

c R

eact

or

Sca

le-u

p: la

rger

dis

c?

R

D =

0.0

66 m

:

R

D =

0.1

35 m

:

Fr

om e

nerg

etic

poi

nt o

f vie

w:

Se

vera

l sm

alle

r dis

cs a

re b

ette

r

than

one

larg

er d

isc

!

31

1.1

m M

JL

GG

L

d

Lk

a E�

�

31

0.4

m M

JL

GG

L

d

Lk

a E�

�

Rot

or –

Sta

tor S

pinn

ing

Dis

c R

eact

or

Mul

tiple

Spi

nnin

g D

iscs

Rea

ctor

�D

iam

eter

dis

c 13

.2 c

m

�M

axim

um d

isc

spee

d 40

00 rp

m

�D

isc

spac

ing

0.5

– 5

mm

�

Coo

led

or h

eate

d di

scs

�D

iscs

coa

ted

with

cat

alys

t �

Co-

and

cou

nter

curr

ent o

pera

tion

Spin

ning

Dis

c Ex

trac

tor

To

tal f

low

rate

of 4

.7 1

0-6 m

³ s-1

.

Hep

tane

app

ears

whi

te, w

ater

app

ears

blu

e

Spin

ning

Dis

c Pe

rfor

man

ce

…..

the

next

min

utes

(or s

o)

� TU

Ein

dhov

en

� Fa

culte

it Sc

heik

undi

ge T

echn

olog

ie

�

Proc

este

chno

logi

e &

Rea

ctor

kund

e � …

.. a

rapi

dly

chan

ging

Wor

ld !

� D

e m

oder

ne c

hem

isch

e re

acto

r:

�

mic

rore

acto

ren

� sp

inni

ng d

isk

reac

tore

n

� D

emo

& “

Tea

Leaf

Par

adox

”

Bro

n: h

ttp://

en.w

ikip

edia

.org

/wik

i/File

:Tea

_Lea

f_Pa

rado

x_St

irrin

g.og

v

Tea

Leaf

Par

adox

Bro

n: A

. Ein

stei

n, N

atur

wis

sens

chaf

ten

26, (

1926

), 22

3

Tea

Leaf

Par

adox

Tea

Leaf

Par

adox

Doo

r het

roer

en k

rijgt

de

thee

een

bep

aald

e ho

eksn

elhe

id. D

eze

zal m

inde

r zijn

in

de b

uurt

van

de b

odem

, om

dat d

e th

ee d

aar d

oor w

rijvi

ng a

frem

t. D

it ge

bied

hee

t de

gren

slaa

g. In

dez

e gr

ensl

aag

wor

dt d

e st

rom

ing

niet

mee

r bep

aald

doo

r de

draa

isne

lhei

d va

n de

thee

, maa

r doo

r min

iem

e dr

ukve

rsch

illen

in d

e vl

oeis

tof.

D

oor d

e ce

ntrif

ugaa

lkra

cht i

s de

dru

k gr

oter

als

we

verd

er v

an h

et m

idde

n ki

jken

. D

e dr

uk a

an d

e w

and

van

de k

op is

dus

hog

er d

an d

ie in

het

mid

den,

waa

rdoo

r een

st

rom

ing

van

de v

loei

stof

van

bui

ten

naar

bin

nen

op g

ang

kom

t, w

elke

de

thee

blaa

djes

mee

slee

pt.