12
Content eurobio ingen PRODUCTION .................................................................................................................................. 1 Customised Antibody production .................................................................................................................... 1 ANTIBODY RANGE .................................................................................................................................................... 2 KitS for human B cell immortalization ............................................................................................................... 2 HuBBB .................................................................................................................................................................. 2 Antibodies for neuroscience .............................................................................................................................. 3 psa-ncam........................................................................................................................................................... 3 Monoclonal Anti-human Alpha -synuclein.................................................................................................. 4 Antibodies for dendritics cells ............................................................................................................................ 5 DC subtypes ...................................................................................................................................................... 5 Toll-like receptors .............................................................................................................................................. 7 DC migration ..................................................................................................................................................... 8 PDC depletion................................................................................................................................................... 8 Others.................................................................................................................................................................. 8 Isotype control ...................................................................................................................................................... 9 Therapeutic antibodies ..................................................................................................................................... 10 Diaxonhit is a key player in the field of specialty in vitro diagnostics and life sciences. It is involved from research to manufacturing and commercialization of diagnostic tests in the fields of transplantation, immunology and infectious diseases, and markets instruments and products for life- science research laboratories, including biotechnology and pharmaceutical companies. Through many partnerships and a strong presence in hospitals, Diaxonhit has established its own distribution network and a portfolio of proprietary products in the molecular biology field. The Diaxonhit Group, based in the Paris region and in the United States, has more than 120 employees. The company is publicly listed on the Euronext Growth market in Paris, and is part of the Euronext Growth BPI Innovation, PEA-PME 150 and Next Biotech indices.

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Page 1: eurobio ingen is a Diaxonhit Group subsidiary company that ... · certification system for medical devices). ... NCAM: catalogue Number AbC0019) was raised against the viable Meningococcal

Content

eurobio ingen PRODUCTION .................................................................................................................................. 1

Customised Antibody production .................................................................................................................... 1

ANTIBODY RANGE .................................................................................................................................................... 2

KitS for human B cell immortalization ............................................................................................................... 2

HuBBB .................................................................................................................................................................. 2

Antibodies for neuroscience .............................................................................................................................. 3

psa-ncam ........................................................................................................................................................... 3

Monoclonal Anti-human Alpha -synuclein .................................................................................................. 4

Antibodies for dendritics cells ............................................................................................................................ 5

DC subtypes ...................................................................................................................................................... 5

Toll-like receptors .............................................................................................................................................. 7

DC migration ..................................................................................................................................................... 8

PDC depletion ................................................................................................................................................... 8

Others.................................................................................................................................................................. 8

Isotype control ...................................................................................................................................................... 9

Therapeutic antibodies ..................................................................................................................................... 10

Diaxonhit is a key player in the field of specialty in vitro diagnostics and life sciences. It is involved

from research to manufacturing and commercialization of diagnostic tests in the fields of

transplantation, immunology and infectious diseases, and markets instruments and products for life-

science research laboratories, including biotechnology and pharmaceutical companies. Through

many partnerships and a strong presence in hospitals, Diaxonhit has established its own distribution

network and a portfolio of proprietary products in the molecular biology field. The Diaxonhit Group,

based in the Paris region and in the United States, has more than 120 employees. The company is

publicly listed on the Euronext Growth market in Paris, and is part of the Euronext Growth BPI

Innovation, PEA-PME 150 and Next Biotech indices.

Page 2: eurobio ingen is a Diaxonhit Group subsidiary company that ... · certification system for medical devices). ... NCAM: catalogue Number AbC0019) was raised against the viable Meningococcal

eurobio ingen

7, avenue de Scandinavie - 91 953 les Ulis - FRANCE

Tel: +33 169 79 64 80

Email: [email protected]

1

EUROBIO INGEN PRODUCTION

Quality, Delay, Reliability

Eurobio ingen is a subsidiary of the Diaxonhit Group, which designs and manufactures innovative

cellular and molecular solutions dedicated to diagnostics, research and transplantation. Its know-

how and production expertise enable it to develop innovative systems compliant with the European

pharmacopoeia standards.

Eurobio ingen designs and produces a complete range of dedicated media, sera

and antibodies. It has extensive experience in biologic systems production. The

facility’s cutting-edge equipment and direct contact with its customers allow it to

achieve very competitive deadlines.

By 2020, the new facilities of 1,000 m2 will boost production even more and

guarantee its commitment to a high-quality service, compliant with the GMP.

Located in the Parisian suburbs close to an international airport, Eurobio ingen has

everything necessary to be able to ship anywhere under ideal conditions.

Quality is essential to Eurobio ingen. The facility is ISO-certified 14001 - French

certification related to the company internally - and ISO 13485 (specific

certification system for medical devices).

The Quality and Regulatory Affairs department strives to satisfy the

rigorous specifications requested by our customers.

Thanks to the merge with Dendritics, the group benefits from a long expertise in human monoclonal

antibody production

Thanks to the merge with Dendritics, we propose to produce antibodies against customer-predefined

targets. We provide customised services for the production of animal and human monoclonal

antibodies. Their recognized efficiency in immunization strategies, hybridoma development and

screening desgin is key to rapid success.

We also propose to purify and conjugate antibodies in addition to mouse and rat hybridoma

technology.

Qualification of the immunogen before starting the program

Production of recombinant proteins in eukaryotic systems

Tolerization step before immunization if necessary

Specific medium additive (booster: an average of 20.000 hybrides/fusion)

Screening using micro-methods (rapid, specific)

CUSTOMISED ANTIBODY PRODUCTION

Page 3: eurobio ingen is a Diaxonhit Group subsidiary company that ... · certification system for medical devices). ... NCAM: catalogue Number AbC0019) was raised against the viable Meningococcal

eurobio ingen

7, avenue de Scandinavie - 91 953 les Ulis - FRANCE

Tel: +33 169 79 64 80

Email: [email protected]

2

ANTIBODY RANGE

Immortalization of human B lymphocytes from peripheral blood samples

HUBBB

Thanks to its long-standing expertise in B-cell physiology, notably in in vitro activation and

immortalization of circulating B lymphocytes, DENDRITICS develops animal (DDXK-AnBBB) and human

monoclonal antibodies (DDXK-HuBBB). This innovative technology allows the development of genuine

antibodies directly starting from the target species (human, rat, mouse, sheep, dog, horse or rabbit).

Scientists aiming to study the physiology of circulating B cells have developed several approaches.

They are generally limited both by the low number of B cells and by their low capacity to enter cell

cycle. Dendritics has developed the innovative Kit HuBBB® that allows the combination of a strong B

cell activation and an efficient B cell transformation using EBV viral suspension prepared according to

proprietary procedures. The Kit HuBBB targets the largest B cell population from peripheral blood in

order to obtain immortalized B cells representative of the overall peripheral B repertoire. Under the

best conditions, the kitHuBBB® allows the immortalization of up to 20% of the starting B cell population.

Easy to handle

Different sizes available

Reference Description Size Price

DDXK-HuBBB-10 Kit for human B cell immortalization 10 x 96 tests 5 355 €

DDXK-HuBBB-5 Kit for human B cell immortalization 5 x 96 tests 3 749 €

DDXK-HuBBB-2 Kit for human B cell immortalization 2 x 96 tests 1 714 €

DDXK-AnBBB-6 Kit for animal B cell immortalization 6 x 96 tests 3 803 €

KITS FOR HUMAN B CELL IMMORTALIZATION

Page 4: eurobio ingen is a Diaxonhit Group subsidiary company that ... · certification system for medical devices). ... NCAM: catalogue Number AbC0019) was raised against the viable Meningococcal

eurobio ingen

7, avenue de Scandinavie - 91 953 les Ulis - FRANCE

Tel: +33 169 79 64 80

Email: [email protected]

3

PSA-NCAM

The PSA-NCAM antibody is the referent biomarker of neural stem cells.

Neural Cell Adhesion Molecule (NCAM) and its polysialylated form PSA

are involved in various aspects of neural and synaptic plasticity.

The Eurobio ingen mouse antibody against PolySialic Acid NCAM (PSA-

NCAM: catalogue Number AbC0019) was raised against the viable

Meningococcal B (strain 355). AbC0019 reacts with alpha 2-8 linked

neuroaminic acid (NeuAc-alpha 2-8) n, with n > 10. This polymer is called

polysialic acid (PSA). In vertebrates, PSA is essentially, if not exclusively,

linked to NCAM (CD56). In bacteria, it is associated with the capsula of

Meningococcal group B.

Neurogenesis

Plasticity

Neural

Neurotoxicology

Diagnostics

Neuroblastoma prognosis

Monoclonal 2-2B (mouse IgM) : Western Blot, immunochemistry, cell sorting and

Radioimmunoassay.

AbC0019 is Universal: it is not restricted to a single species and it can be used in various species

(including mice).

ABC0019 anti-PSA-NCAM monoclonal antibody clone 2-2B 50µl 452

ABC0027B Elisa PSA-NCAM assay 96 wells 887

ABC0026 anti-NCAM 200µl 378

ABC0020 endo-N ( endoneuraminidase-N) 50µl 553

ABC0101 anti-Glu-Tubulin 300µg 1113

ABC0102 anti-Tubulin Delta-2 300µg 507

ANTIBODIES FOR NEUROSCIENCE

Applications

Page 5: eurobio ingen is a Diaxonhit Group subsidiary company that ... · certification system for medical devices). ... NCAM: catalogue Number AbC0019) was raised against the viable Meningococcal

eurobio ingen

7, avenue de Scandinavie - 91 953 les Ulis - FRANCE

Tel: +33 169 79 64 80

Email: [email protected]

4

MONOCLONAL ANTI-HUMAN ALPHA -SYNUCLEIN

Dendritics Product reference: DDX0910

α-synuclein (snca) is a140 aas neuronal protein predominantly

present in synaptic junctions, specially studied for its relevance

in understanding sporadic and familial forms of Parkinson’s

disease and related neurodegenerative disorders. In an

attempt to break the immunotolerance since the amino-

acid sequence is highly conserved between species

(95.3% homology between human and mouse), we have

immunized C57BL/6 inbred mice presenting a natural

deletion for snca with recombinant human α-synuclein and

obtained a murine mAb (AS11) recognizing endogenous human α-

synuclein.

Clone: AS11

Species: mouse

Specificity: N-terminal portion of human α-synuclein (aa1-60)

Immunogen: rhu α-synuclein (SIGMA)

Species cross-reactivity: negative for murine α-synuclein

Isotype: IgG Purification: QMA Hyper D ion exchange chromatography

Formulation/size: Purified: 100 µg in 200 µl /50 µg in 100 µl Tris-NaCl pH 8

Coupled: 100 µg in 200µl /50 µg in 100 µl PBS 50% glycerol Available format

Applications tested : IHC, IF

(Kahle et al.,2000, J Neurosci 2000;20:6365–73 ; Specht and Schoepfer, BMC Neurosci 2001;2:11 ;

Mougenot AL et al, J Neurosci Methods. 2010 Oct 15;192(2):268-76).

Reference Description Size Price €

DDX0910P-100 anti-α-Synuclein clone AS11purifié 100µg 293

DDX0910A488-100 anti-α-Synuclein clone AS11 alexa 488 labeled 100µg 364

DDX0910A546-100 anti-α-Synuclein clone AS11 alexa 546 labeled 100µg 364

DDX0910A647-100 anti-α-Synuclein clone AS11 alexa 646 labeled 100µg 364

DDX0910-HRPO-100 anti-α-Synuclein clone AS11 HRPO labeled 100µg 334

Publications:

Page 6: eurobio ingen is a Diaxonhit Group subsidiary company that ... · certification system for medical devices). ... NCAM: catalogue Number AbC0019) was raised against the viable Meningococcal

eurobio ingen

7, avenue de Scandinavie - 91 953 les Ulis - FRANCE

Tel: +33 169 79 64 80

Email: [email protected]

5

Thanks to the acquisition of DENDRITICS, Eurobio ingen provides a large range of

antibodies for dendritic cells and human antibodies you can find. A panel of

monoclonal antibody phenotypes and function characterization of dendritic cells

(DC) will allow you to solve various issues in DC biology.

DC SUBTYPES

Reference Description Size Price €

DDX0010 ASGPR/CD301 clone 125A10.03

(Alexa 488 - Alexa 546 - Alexa 647 - Biotin - Purified) 100 µg *

DDX0011 ASGPR/CD301 clone 121A5.01 (Alexa 488 - Alexa 546 - Alexa 647 -

Biotin - Purified) 100 µg *

DDX0080 CD1a clone 214A9.01 (Alexa 488 - Alexa 546 - Alexa 647 - Biotin -

Purified) 100 µg *

DDX0081 CD1a clone 201B5.08 (Alexa 488 - Alexa 546 - Alexa 647 - Biotin -

Purified) 100 µg *

DDX0040 CD303/BDCA2 clone 108H10.03 (Alexa 488 - Alexa 546 - Alexa 647

- Biotin - Purified) 100 µg *

DDX0041 CD303/BDCA2 clone 104C12.08 (Alexa 488 - Alexa 546 - Alexa

647 - Biotin - Purified) 100 µg *

DDX0042 CD303/BDCA2 clone 110H7.05 (Alexa 488 - Alexa 546 - Alexa 647 -

Biotin - Purified) 100 µg *

DDX0043 CD303/BDCA2 clone 124B3.13 (Alexa 488 - Alexa 546 - Alexa 647 -

Biotin - Purified) 100 µg *

DDX0045 CD303/BDCA2 clone 109B8 (Alexa 488 - Alexa 546 - Alexa 647 -

Biotin - Purified) 100 µg *

DDX0440 CD304/Neuropilin-1 clone 211H6.01 (Alexa 488 - Alexa 546 - Alexa

647 - Biotin - Purified) 100 µg *

DDX0130 CD40 clone G28-5 (Purified) 100 µg *

DDX0131A488-

100 CD40 clone mAb89 (Alexa 488) 100 µg 314

DDX0131P-100 CD40 clone mAb89 (Purified) 100 µg 250

DDX0140 CD40L/CD154 clone LL48 (Purified) 100 µg *

DDX0141 CD40L/CD154 clone LL2 (Alexa 647 - Purified) 100 µg *

DDX0150 CD54 clone 117G12.02 (Purified) 100 µg *

ANTIBODIES FOR DENDRITICS CELLS

Referring prices for DDX subtypes

ALEXA 488 507 €

ALEXA 564 507 €

ALEXA 647 507 €

BIOTIN 465 €

PURIFIED 405 €

HRPO 465 €

Page 7: eurobio ingen is a Diaxonhit Group subsidiary company that ... · certification system for medical devices). ... NCAM: catalogue Number AbC0019) was raised against the viable Meningococcal

eurobio ingen

7, avenue de Scandinavie - 91 953 les Ulis - FRANCE

Tel: +33 169 79 64 80

Email: [email protected]

6

DDX0151 CD54 clone 217E2.10 (Alexa 488 - Alexa 546 - Alexa 647 - Purified) 100 µg *

DDX0180 DCIR clone 111F8.04 (Alexa 488 - Alexa 546 - Alexa 647 - Biotin -

Purified) 100 µg *

DDX0190A488-

100 DC-LAMP/CD208 clone 104G4 (Alexa 488) 100 µg 314

DDX0190A546-

100 DC-LAMP/CD208 clone 104G4 (Alexa 546) 100 µg 314

DDX0190A647-

100 DC-LAMP/CD208 clone 104G4 (Alexa 647) 100 µg 314

DDX0190B-100 DC-LAMP/CD208 clone 104G4 (Biotin) 100 µg 291

DDX0190P-100 DC-LAMP/CD208 clone 104G4 (Purified) 100 µg 250

DDX0191 DC-LAMP/CD208 clone 1010E1.01 (Alexa 488 - Alexa 546 - Alexa

647 - Biotin - Purified) 100 µg *

DDX0192 DC-LAMP/CD208 clone 1006F7.05 (Alexa 488 - Alexa 546 - Alexa

647 - Biotin - Purified) 100 µg *

DDX0193 DC-LAMP/CD208 clone 109G3 (Alexa 488 - Alexa 546 - Alexa 647 -

Biotin - Purified) 100 µg *

DDX0195 DC-LAMP/CD208 clone 208B5 (Alexa 488 - Alexa 546 - Alexa 647 -

Biotin - Purified) 100 µg *

DDX0202 DC-SIGN/CD209 clone 102E11.06 (Alexa 488 - Alexa 546 - Alexa

647 - Biotin - Purified) 100 µg *

DDX0203 DC-SIGN/CD209 clone 103G2.07 (Alexa 488 - Alexa 546 - Alexa

647 - Biotin - Purified) 100 µg *

DDX0204 DC-SIGN/CD209 clone 108C7.01 (Alexa 488 - Alexa 546 - Alexa

647 - Biotin - Purified) 100 µg *

DDX0205 DC-SIGN/CD209 clone 102F10.04

(Alexa 488 - Alexa 546 - Alexa 647 - Purified) 100 µg *

DDX0207 DC-SIGN/CD209 clone 109H12.03 (Alexa 488 - Alexa 546 - Alexa

647 - Biotin - Purified) 100 µg *

DDX0208 DC-SIGN/CD209 clone 120C11.01 (Alexa 488 - Alexa 546 - Alexa

647 - Biotin - Purified) 100 µg *

DDX0209 DC-SIGN/CD209 clone 111H2.02 (Alexa 488 - Alexa 647 - Biotin -

Purified) 100 µg *

DDX0020 DEC205/CD205 clone NLDC145 (Alexa 488 - Alexa 546 - Biotin -

Purified) 100 µg *

DDX0220 DORA/IgSF6 clone 104A10.01 (Alexa 488 - Alexa 546 - Alexa 647 -

Biotin - Purified) 100 µg *

DDX0230 FDF03 CLONE 36H2

(Alexa 488 - Alexa 546 - Alexa 647 - Biotin - Purified) 100 µg *

DDX0300A488-

100 IL3R alpha/CD123 clone 107D2.08 (Alexa 488) 100 µg 314

DDX0300A546-

100 IL3R alpha/CD123 clone 107D2.08 (Alexa 546) 100 µg 314

DDX0300A647-

100 IL3R alpha/CD123 clone 107D2.08 (Alexa 647) 100 µg 314

DDX0300B-100 IL3R alpha/CD123 clone 107D2.08 (Biotin) 100 µg 291

DDX0300P-100 IL3R alpha/CD123 clone 107D2.08 (Purified) 100 µg 250

DDX0301 IL3R alpha/CD123 clone 106C2.02 (Alexa 488 - Alexa 546 - Alexa

647 - Biotin - Purified) 100 µg *

Page 8: eurobio ingen is a Diaxonhit Group subsidiary company that ... · certification system for medical devices). ... NCAM: catalogue Number AbC0019) was raised against the viable Meningococcal

eurobio ingen

7, avenue de Scandinavie - 91 953 les Ulis - FRANCE

Tel: +33 169 79 64 80

Email: [email protected]

7

DDX0360 Langerin/CD207 clone 808E10.01 (Alexa 488 - Alexa 546 - Alexa

647 - Biotin - Purified) 100 µg *

DDX0361 Langerin/CD207 clone 310F7.02 (Alexa 488 - Alexa 546 - Alexa 647

- Biotin - Purified) 100 µg *

DDX0362 Langerin/CD207 clone 929F3.01 (Alexa 488 - Alexa 546 - Alexa 647

- Biotin - Purified) 100 µg *

DDX0363A488-

100 Langerin/CD207 clone DCGM4 / 122D5.03 (Alexa 488) 100 µg 314

DDX0363A546-

100 Langerin/CD207 clone DCGM4 / 122D5.03 (Alexa 546) 100 µg 314

DDX0363A647-

100 Langerin/CD207 clone DCGM4 / 122D5.03 (Alexa 647) 100 µg 314

DDX0363B-100 Langerin/CD207 clone DCGM4 / 122D5.03 (Biotin) 100 µg 291

DDX0363P-100 Langerin/CD207 clone DCGM4 / 122D5.03 (Purified) 100 µg 250

DDX0368 Langerin/CD207 clone 306G9.01 (Alexa 488 - Alexa 546 - Alexa

647 - Biotin - Purified) 100 µg *

DDX0373 Langerin/CD207 clone 923B7 100 µg *

DDX0375 Langerin/CD207 clone 929F7 100 µg *

DDX0376 Langerin/CD207 clone 918A11 100 µg *

DDX0377 Langerin/CD207 clone 817G7 100 µg *

DDX0380 Mannose-Receptor/CD206 clone 122D2.08 (Purified) 100 µg *

DDX0462 Sema6A clone 104B3 (Alexa 488 - Alexa 546 - Alexa 647 - Purified) 100 µg *

DDX0463 Sema6A clone 118E7 (Alexa 488 - Alexa 546 - Alexa 647 - Purified) 100 µg *

TOLL-LIKE RECEPTORS

The Toll-like receptors (TLRs) represent the prototype pattern recognition receptors (PRRs)

characterized by a high degree of evolutionary conservation. Since the discovery of Drosophila “Toll”,

a number of homologous TLRs have been identified in mammals (1). 10 genes encoding TLRs have

been identified in humans. In the mouse, 13 such genes are described, although the murine equivalent

of human Tlr10 is a pseudogene

Reference Description Size Price €

DDX0340 IRAK4 clone 6F8 (Alexa 488 - Alexa 546 - Alexa 647 - Biotin - Purified) 100 µg *

DDX0341 IRAK4 clone 7F8 (Alexa 488 - Alexa 546 - Alexa 647 - Purified) 100 µg *

DDX1400 Myd88 clone 603E10.05 (Purified) 100 µg *

DDX1401 Myd88 clone 603E10.06 (Purified) 100 µg *

DDX0490 TLR10/CD290 clone 25F9 (Purified) 100 µg *

DDX0492 TLR10/CD290 clone 9F4 (Purified) 100 µg *

DDX0200 TLR3/CD283 clone 619F7.06 (Alexa 488 - Alexa 546 - Alexa 647 - Biotin -

Purified) 100 µg *

DDX0201 TLR3/CD283 clone 722E2.01 (Alexa 488 - Alexa 546 - Alexa 647 - Biotin -

Purified) 100 µg *

DDX0474 TLR3/CD283 clone 713E4.06 (Alexa 488 - Alexa 546 - Alexa 647 - Biotin -

Purified) 100 µg *

Page 9: eurobio ingen is a Diaxonhit Group subsidiary company that ... · certification system for medical devices). ... NCAM: catalogue Number AbC0019) was raised against the viable Meningococcal

eurobio ingen

7, avenue de Scandinavie - 91 953 les Ulis - FRANCE

Tel: +33 169 79 64 80

Email: [email protected]

8

DDX0475 TLR3/CD283 clone 716G10.15 (Alexa 488 - Alexa 546 - Alexa 647 - Biotin -

Purified) 100 µg *

DDX0476 TLR3/CD283 clone 1213F10 (Alexa 488 - Alexa 546 - Alexa 647 - Purified) 100 µg *

DDX0477 TLR3/CD283 clone 1210F1 (Alexa 488 - Alexa 546 - Alexa 647 - Purified) 100 µg *

DDX0500 TLR7/CD287 clone 66H3 (Purified) 100 µg *

DDX0501 TLR7/CD287 clone 85D6 (Alexa 488 - Alexa 546 - Alexa 647 - Biotin - Purified) 100 µg *

DC MIGRATION

Reference Description Size Price €

DDX0280 MMP12/HME clone 603E6.22 (HRPO - Biotin - Purified) 100 µg *

DDX0281 MMP12/HME clone 706F9.01 (HRPO - Biotin - Purified) 100 µg *

DDX0282 MMP12/HME clone 705D10.11 (HRPO - Biotin - Purified) 100 µg *

DDX0283 MMP12/HME clone 703D10 (HRPO - Biotin - Purified) 100 µg *

DDX0284 MMP12/HME clone 701E4.03 (HRPO - Biotin - Purified) 100 µg *

DDX0420

MIP3 alpha/CCL20 clone 206D9.05 (Alexa 488 - Alexa 546 -

HRPO- Biotin - Purified) 100 µg *

DDX0430 MIP3 alpha/CCL20 clone 319F6.07 (Purified) 100 µg *

DDX0431 MIP3 alpha/CCL20 clone 308B7.06 (HRPO - Biotin - Purified) 100 µg *

PDC DEPLETION

Reference Description Size Price €

DDX0390

pDC/BST2 clone 120G8.04

(Alexa 488 - Alexa 546 - Alexa 647 - Biotin - Purified) 100 µg *

DDX0390HD01 pDC/BST2 clone 120G8.04 (Purified) 1 mg 835

DDX0390HD05 pDC/BST2 clone 120G8.04 (Purified) 5 mg 2 981

DDX0390HD10 pDC/BST2 clone 120G8.04 (Purified) 10 mg 4 771

OTHERS

Reference Description Size Price €

DDX0700A488-100 IL7-R alpha/CD127 clone R34.34 (Alexa 488) 100 µg 314

DDX0700A546-100 IL7-R alpha/CD127 clone R34.34 (Alexa 546) 100 µg 314

DDX0700A647-100 IL7-R alpha/CD127 clone R34.34 (Alexa 647) 100 µg 314

DDX0700P-100 IL7-R alpha/CD127 clone R34.34 (Purified) 100 µg 250

Page 10: eurobio ingen is a Diaxonhit Group subsidiary company that ... · certification system for medical devices). ... NCAM: catalogue Number AbC0019) was raised against the viable Meningococcal

eurobio ingen

7, avenue de Scandinavie - 91 953 les Ulis - FRANCE

Tel: +33 169 79 64 80

Email: [email protected]

9

Reference Description Size Price €

DDXCM01A488-100 mouse isotype control IgG1 (Alexa 488) 100 µg 123

DDXCM01A546-100 mouse isotype control IgG1 (Alexa 546) 100 µg 123

DDXCM01A647-100 mouse isotype control IgG1 (Alexa 647) 100 µg 123

DDXCM01P-100 mouse isotype control IgG1 (Purified) 100 µg 93

DDXCM02A488-100 mouse isotype control IgG2a (Alexa 488) 100 µg 123

DDXCM02A546-100 mouse isotype control IgG2a (Alexa 546) 100 µg 123

DDXCM02A647-100 mouse isotype control IgG2a (Alexa 647) 100 µg 123

DDXCM02P-100 mouse isotype control IgG2a (Purified) 100 µg 93

DDXCM03A488-100 mouse isotype control IgG3 (Alexa 488) 100 µg 123

DDXCM03A546-100 mouse isotype control IgG3 (Alexa 546) 100 µg 123

DDXCM03A647-100 mouse isotype control IgG3 (Alexa 647) 100 µg 123

DDXCM03P-100 mouse isotype control IgG3 (Purified) 100 µg 93

DDXCM04A488-100 mouse isotype control IgM (Alexa 488) 100 µg 123

DDXCM04A546-100 mouse isotype control IgM (Alexa 546) 100 µg 123

DDXCM04A647-100 mouse isotype control IgM (Alexa 647) 100 µg 123

DDXCM04P-100 mouse isotype control IgM (Purified) 100 µg 93

DDXCR01A488-100 rat isotype control IgG1 (Alexa 488) 100 µg 123

DDXCR01A546-100 rat isotype control IgG1 (Alexa 546) 100 µg 123

DDXCR01A647-100 rat isotype control IgG1 (Alexa 647) 100 µg 123

DDXCR01P-100 rat isotype control IgG1 (Purified) 100 µg 93

DDXCR02A488-100 rat isotype control IgG2a (Alexa 488) 100 µg 123

DDXCR02A546-100 rat isotype control IgG2a (Alexa 546) 100 µg 123

DDXCR02A647-100 rat isotype control IgG2a (Alexa 647) 100 µg 123

DDXCR02P-100 rat isotype control IgG2a (Purified) 100 µg 93

DDXCR03A488-100 rat isotype control IgG2b (Alexa 488) 100 µg 123

DDXCR03A546-100 rat isotype control IgG2b (Alexa 546) 100 µg 123

DDXCR03A647-100 rat isotype control IgG2b (Alexa 647) 100 µg 123

DDXCR03P-100 rat isotype control IgG2b (Purified) 100 µg 93

DDXCR04A488-100 rat isotype control IgG3 (Alexa 488) 100 µg 123

DDXCR04A546-100 rat isotype control IgG3 (Alexa 546) 100 µg 123

DDXCR04A647-100 rat isotype control IgG3 (Alexa 647) 100 µg 123

DDXCR04P-100 rat isotype control IgG3 (Purified) 100 µg 93

DDXCR05A488-100 rat isotype control IgM (Alexa 488) 100 µg 123

DDXCR05A546-100 rat isotype control IgM (Alexa 546) 100 µg 123

DDXCR05A647-100 rat isotype control IgM (Alexa 647) 100 µg 123

DDXCR05P-100 rat isotype control IgM (Purified) 100 µg 93

ISOTYPE CONTROL

Page 11: eurobio ingen is a Diaxonhit Group subsidiary company that ... · certification system for medical devices). ... NCAM: catalogue Number AbC0019) was raised against the viable Meningococcal

eurobio ingen

7, avenue de Scandinavie - 91 953 les Ulis - FRANCE

Tel: +33 169 79 64 80

Email: [email protected]

10

The therapeutic use of chimeric or humanized antibodies such as Remicade®, Mabthera® or

Roactemra® has greatly improved the treatment of several autoimmune diseases (rheumatoid

arthritis, psoriasis, inflammatory bowel disease, Crohn's disease, ulcerative colitis, leukemias, or

lymphomas). However, therapeutic failure is observed in a significant proportion of patients treated

with therapeutic antibodies. Among several hypothesis, the development of an anti-drug response

(Anti-drug antibody (ADA)) may explain the loss of response due either to degradation and/or to

neutralization of the drug effect. Therefore, accurate monitoring of drug and anti-drug antibody levels

should be implemented in routine clinical practices.

Eurobio ingen provides a panel of murine monoclonal antibodies against Remicade®, Mabthera® or

Roactemra® intended to monitor the level of therapeutic antibodies and anti-drug antibodies in

patient’s sera

Reference Description Size Price €

DDX5030P-100 Anti-Humira (Adalimumab) clone 304B12.04 (Purified) 100 µg 153

DDX5030B-100 Anti-Humira (Adalimumab) clone 304B12.04 (Biotin) 100 µg 177

DDX5032P-100 Anti-Humira (Adalimumab) clone 305A4.06 (Purified) 100 µg 153

DDX5032B-100 Anti-Humira (Adalimumab) clone 305A4.06 (Biotin) 100 µg 177

DDX5031P-100 Anti-Humira (Adalimumab) clone 310D9.03 (Purified) 100 µg 153

DDX5031B-100 Anti-Humira (Adalimumab) clone 310D9.03 (Biotin) 100 µg 177

DDX5011P-100 Anti-Mabthera(Rituximab) clone 108F11.02 (Purified) 100 µg 153

DDX5011B-100 Anti-Mabthera(Rituximab) clone 108F11.02 (Biotin) 100 µg 177

DDX5010P-100 Anti-Mabthera(Rituximab) clone 109H9.06 (Purified) 100 µg 153

DDX5010B-100 Anti-Mabthera(Rituximab) clone 109H9.06(Biotin) 100 µg 177

DDX5040P-100 Anti-Orencia (Abatacept) clone 309C2.01 (Purified) 100 µg 153

DDX5040B-100 Anti-Orencia (Abatacept) clone 309C2.01 (Biotin) 100 µg 177

DDX5041P-100 Anti-Orencia (Abatacept) clone 310G6.01 (Purified) 100 µg 153

DDX5041B-100 Anti-Orencia (Abatacept) clone 310G6.01 (Biotin) 100 µg 177

DDX5002P-100 Anti-Remicade(Infliximab) clone 103A8.03 (Purified) 100 µg 153

DDX5002B-100 Anti-Remicade(Infliximab) clone 103A8.03 (Biotin) 100 µg 177

DDX5001P-100 Anti-Remicade(Infliximab) clone 108G4.03 (Purified) 100 µg 153

DDX5001B-100 Anti-Remicade(Infliximab) clone 108G4.03 (Biotin) 100 µg 177

DDX5021P-100 Anti-Roactemra(Tocilizumab) clone 101G1.01 (Purified) 100 µg 153

DDX5022B-100 Anti-Roactemra(Tocilizumab) clone 105D9.05 (Biotin) 100 µg 177

DDX5020P-100 Anti-Roactemra(Tocilizumab) clone 107D8.04 (Purified) 100 µg 153

DDX5020B-100 Anti-Roactemra(Tocilizumab) clone 107D8.04 (Biotin) 100 µg 177

THERAPEUTIC ANTIBODIES

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DDX5001108G4.03 Remicade/Infliximab Mouse IgG1 Remicade (Infliximab) and anti-remicade (anti-Infliximab) detection antibody

DDX5002103A8.03 Remicade/Infliximab Mouse IgG1 Remicade (Infliximab) and anti-remicade (anti-Infliximab) detection antibody

DDX5010109H9.06 Mabthera/Rituximab Mouse IgG1 Mabthera (Rituximab) and anti-mabthera (anti-Rituximab) detection antibody

DDX5011108F11.02 Mabthera/Rituximab Mouse IgG1 Mabthera (Rituximab) and anti-mabthera (anti-Rituximab) detection antibody

DDX5020107D8.04 Roactemra/Tocilizumab Mouse IgG2a Roactemra (Tocilizumab) and anti-roactemra (anti-Tocilizumab) detection antibody

DDX5021101G1.01 Roactemra/Tocilizumab Mouse IgG1 Roactemra (Tocilizumab) and anti-roactemra (anti-Tocilizumab) detection antibody

DDX5030304B12.04 Humira/Adalimumab Mouse IgG1 Humira (Adalimumab) and anti-Humiar (anti-Adalimumab) detection antibody

DDX5031310D9.03 Humira/Adalimumab Mouse IgG2a Humira (Adalimumab) and anti-Humira (anti-Adalimumab) detection antibody

DDX5032305A4.06 Humira/Adalimumab Mouse IgM Humira (Adalimumab) and anti-Humiar (anti-Adalimumab) detection antibody

DDX5040309C2.01 Orencia/Abatacept Mouse IgG1 Orencia (Abatacept) and anti-Orencia (anti-Abatacept) detection antibody