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8/14/2019 Eternity Soup by Greg Critser - Excerpt
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8/14/2019 Eternity Soup by Greg Critser - Excerpt
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Soup
GREG CRISER
H a r m o n y B o o k s
new york
Eternity
Inside
the
Ques t
to
End
Aging
8/14/2019 Eternity Soup by Greg Critser - Excerpt
3/15
Copyrigh by Grg Crisr
All righs rsrvd.
Publishd in h Unid Sas by Harmony Books,
an imprin o h Crown Publishing Group,
a division o Random Hous, Inc., Nw York.
www.crownpublishing.com
Harmony Books is a rgisrd radmarkand h Harmony Books colophon
is a radmark o Random Hous, Inc.
Library o Congrss Caaloging-in-Publicaion Daa
Crisr, Grg.
Ernit soup / Grg Crisr
p. cm.Includs bibliographical rrncs and indx.
. Longvit. . AgingPrvnion. I. il.
RA..C
.dc
ISBN -
Prind in h Unid Sas o Amrica
Desgn by Elzabeh Rendeich
Illusraons by Andrew Barhelmes
Firs Ediion
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To purchase a copy of
Eternity Soup
visit one of these online retailers:
www.HarmonyBooks.com
http://www.randomhouse.com/catalog/display.pperl?isbn=9780307407900&ref=other_scribd-pdf-random-eterni-0210http://www.powells.com/biblio/62-9780307407900-0http://www.indiebound.org/book/9780307407900http://www.tkqlhce.com/click-2665379-10568661?url=http://www.borders.com/online/store/TitleDetail?sku=030740790X&cmpid=pub-rh-56http://search.barnesandnoble.com/Eternity-Soup/Greg-Critser/e/9780307462503&afsrc=1&lkid=J28248944&pubid=K124596&byo=1http://www.amazon.com/Eternity-Soup-Inside-Quest-Aging/dp/030740790X?tag=randohouseinc2-208/14/2019 Eternity Soup by Greg Critser - Excerpt
5/15
Contents
INRODUCION x i i i
book one Calories
book two Cash
book three Engineering
book four The New Longevity Bestiary
book five One Million Centenarians
REC IPES FOR EERNIY
NOES
SELEC BIBLIOGRAPHY
ACKNOWLEDGMENS
C REDIS
INDEX
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INTRODUCTION
W wr lunching in Gods waiing room, which is wha Bob
Hop likd o call Palm Springs, whn h subjc o aging
cam up.
I was a good abl or h subjc, bcaus i you wrlooking or o raional xampls o halhy aging, you prob-
ably couldn do br han my mohr, B , svnt-six, and
hr husband, Jrry, svnt-v. Tyv go i down: a simpl,
snsibl di wih an occasional splurg, rouin daily xrcis,
som yoga, los o socializing, and los o mnal simulaion
via ravl, books, hobbis, and adul ducaion. Tyr h
griaric dram amsnsibl, modra, willing o ry nw
hings, and proaciv whn i coms o seing hir kids and
grandkids. Tyr no going o si and rumina ovryourno
coming o se hm. Tyll com o seyou.
Ty ar also hug and airly discriminaing consumrs o
halh and mdical inormaion, and so i was wih som rlish
ha, on day ovr lunch no long ago, I old hm abou somnw rsarch Id ben rading on aging and halh. You se,
I said, dropping ino PowrPoin mod, h ral issu isn
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xiv i n t r o d u c t i o n
li span, is healhspan. And wha do w know abou ha?
Wll, w know ha halhy aging is jus haand ha wha
mdicin should aim or is lnghning h healhspan, no h
li span.
Ty lookd a m a lil blankly and pickd a hir salads.
I wn on. And so, has ld o kind o a nw Holy Grail in
aging rsarchh ida o rcangularizaion o morbidit.
Mor blank sars. Forks now on pla.
. . . caus, se, i you look a aging dmographics, you seha h survival curv gos lik his . . .
I racd a downward-sloping lin on h ablcloh wih my
ngr.
. . . wih incrasing sicknss and disas as popl g oldr.
Wha w rally wan o do is mak i squar off, lik his, a,
say, ag ight-v.I racd a nint-dgre angl, downward.
Wha dos ha man? my mom askd.
Oh, simpl, I said. I mans ha h goal o mdical
and aging rsarch should b o g you o, say, ight-o or
ight-v in good halh, and hn you drop off as, say, in
hre o six monhs, wihou xndd illnss.
Tr was a silnc, and I knw I was in roubl.
Oh, my mohr said, I don go along wih ha a all. . . .
Uh-uh, said Jrry. Tas no how wr seing i a all.
T way I se i, Im going o liv o on hundrd and
mayb mor, my mohr said. Why no? And a halhy hun-
drd a ha! Sh pickd up hr ork andniclysabbd
an arichok har o dah.I sid mysl fom poining ou ha hir gn pools did
no augur wll or such opimism, bu, a his poin, hy ownd
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i n t r o d u c t i o n xv
h convrsaion. I wasn aking ino considraion somhing
hy boh semd o know a lo abou: aniaging mdicin. Ty
boh had a longvit docor. Tir ramns includd pr-
scripion compoundd hormons, sosron or him and
progsron cram or hr. Tr wr all kinds o hings you
could do o slow down h aging procss.
Bu, Ma, I said, you know ha hrs no vidnc ha
ha suff dos any mor or lss or you han aking prscrip-
ion hormons!Ah! Bu hr is! T diffrnc is h cram is ailor-
mad or m! I g a blood s vry monh o mak sur. And
GrgoryI know you wro a book abou all hisbu I am
lling you i works! My skin hasn ben lik his or nt
yars! And my nrgy lvl oo. And Im no vn doing my
yoga as much, so I know is h cram. Is dnily makingm el youngr. And fankly, Grgory, I don vn hink o
aging h sam way anymor. Aging, lik ha I man, whn
you rally hink abou i, is so unnaural!
Driving hom ha day, I hough a lo abou ha las sa-
mn, h noion ha aging was somhow unnaural. I was h
kind o dimnsional shi in prcpion ha lads you o hink
ha, onc again, jus lik ha crazy Inrn hing, modrn
li has passd you by. Eihr ha, or ha vryon around you
has gon oally off h grid.
Ar all, vryon knows ha aniaging mdicin is bogus,
righ? Crainly all h righ-hinking olk hink so. Evn h
somnoln FDA rcnly raidd a bunch o pharmacis or
slling aniaging compounds. T Gronological Socit oAmricals call i Big Gsponsors sminars on aniag-
ing quackry. A group o Big G rsarchrs has vn akn o
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xvi i n t r o d u c t i o n
issuing consnsus dics agains aniaging mdicin, on no-
ing is mor obvious fauds whil impaling h whol noion as
quackry. Som o hs aacks ar srangly prsonal, singling
ou bona d rsarchrs who diffrd fom h sablishmn
lin as rogus and impaling ohrs or bing clbriis.
Bu somhing has bohrd ohrs in h lds o aging
and mdicin abou his consnsus. Whn you lookd a lil
hardr, you saw ha som o h biggr nams had rusd o
sign on. I was oo soon o ak such a cnsoring posiion, hysaid. Youngr sciniss viwd i as a gnraional a on. As a
gradua sudn namd Adam Spong, a cll biology rsarchr
a Souhrn Illinois Univrsit Mdical School, old m, Tir
whol hing is jus so, so . . . posmodrn in ha s way. I
man, you canno alk abou aging as a disas, bcaus ha
would b agis. You canno alk abou somhing objcivlyacualha i is br, physiologically, o b young han
b oldwihou supposdly causing sigma or vicimizing h
ldrly. o m i all sinks o som wird, sl-daing orho-
doxy, call i poliical corrcnss, i you wan.
In ac, h mor on looks a aniaging, or longvit, sci-
nc and mdicin, h mor on ses ha hr is no ral con-
snsus abou i a all, and ha myriad nrpriss, boh public
and priva, ar orging onward ino a brav nw pro-longvis
world. Considr, or xampl, ha:
Sanord Univrsit prossor Shripad uljapurkar, an
xpr in populaion mahmaics, projcs ha ani-
aging advancs in dvlopd counris could incrasli xpcancy by a year for each yearo h dcads
o .
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i n t r o d u c t i o n xvii
T Naional Insiu on Aging, h counrys d-
rally undd arbir o gronology, is now undr-
wriing a long- rm, wid-ranging program o s
li-span-xnding compounds on mic a hre lad-
ing rsarch insiuions. Alhough dsignd o dbunk
commrcial claims, h arly rsuls hav alrady
idnid hre compounds ha xnd maximum li
span in mica hug surpris o h ddicad skp-
ics running h rials. Anohr NIA sudy, h rs on humans, showd ha
hickning o h caroid arry, a ky sign o aging and
a risk acor or srok, was dramaically rducd in
praciionrs o caloric rsricion.
Whn h nod RAND Corporaion askd h naions
lading gronologiss, cardiologiss, and griariciansabou h possibilit o a major li-span-xnding
compound, many wr surprisingly bullish, wih a
numbr prdicing a prcn chanc o such a com-
pound in h nx n yars.
T cooundr o PayPal, Pr Til, on o h nan-
cial worlds shrwds invsors, has pu $. million
ino a projc o do nohing lss han nd aging.
T pharmacuicals gian Glaxo rcnly paid $
million or h dvlopmn righs o rsvrarol, a
compound ha sems, among ohr hings, o slow h
undrlying aging procss in som lab animals
T had o Ric Univrsits prsigious nvironmn-
al nginering dparmn, considrd on o h bsin h world, is now lading an xprimn ha will
us soil bacria o arg and dsroy human arrial
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xviii i n t r o d u c t i o n
plaqu, ssnially craing a way, in h words o on
rsarchr, o nd arrial aging as w know i.
T NIH is unding rials in pig-o-prima organ rans-
planaion, hoping o push h scinc closr o usul-
nss bor currn dmographic rnds worsn and
organ dmand ousrips supply vn mor dramaically
han a prsn.
Aging Amricans ar no longr waiing or brak-
hrough scinc or Big Pharma. A soaring numbr oprscripions going ou h pharmacy door hs days
is or a hormon-basd produc, mos o hm usd or
aniaging purposs. Insrucivly, i is almos always
paid or in cash.
I com o his rmarkabl and as-moving world wih myown biass and prjudics. Lik mos popl, I wan aniag-
ing mdicin o work, spcially sinc mn in my linag don
nd o liv vry long. Tr ar lovd ons all around m whom
Id lik o njoy a lo longr. And, surpris: I hink h bodily
and mnal dgradaion ha coms wih advancd yars is
crul, capricious, and unrlning, and h amps o main-
ain ons dignit in h ac o i ar oo on clownish, pii-
ul and, ulimaly, inffciv. A rcn concussionwhich
rsuld in a orm o acclrad brain aging and or which
I sough ramn in aniaging mdicin ar convnional
mdicin ailddrov ha poin hom in a prsonal way. A
jock would say ha Iv go skin in h gam.
T mor I lookd, h mor i semd o m ha, ovr hnx y yars, scinc, mdicin, and chnology will rans-
orm agingand h way w hink abou i. Tis chang will
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i n t r o d u c t i o n xix
com in ways small and larg, is voluion gradual bu inxo-
rabl, uld by boh sl-xprimnaion and publicly undd
rials. Much o i will ak plac in rra incognia; aging may
bcom asir and mor comorabl, bu mor xpnsiv and
vn a lil riskir, oo.
So whr dos aniaging, or longvit, scinc com fom,
wha dos i ll us, how dos i connc (or no) wih radi-
ional mdicin and mdical scinc, and how will w hink
o our own bodis as a rsul? Tos ar h qusions hisbook will ry o answr. o sar, w mus rs go o ucson,
Arizona.
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Clve McCay, he faher of modern longevt scence,and one of hi subjecs, crca .
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About the Author
GREG CRITSERis a longime journalis and observer
of he medical indusry. He is he auhor of Fa Land:
How Americans Became he Fates People in he Worldand Generaion Rx: How Prescripion Drugs Are Alering
American Lives, Minds, and Bodies. His work has ap-
peared in dozens of magazines and newspapers, and he
is a well-known commenaor on medicine, healh, and
food, wih regular appearances on public radio and TV.
He lives in Pasadena wih his wife, Anoinete Mongelli.
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To purchase a copy of
Eternity Soup
visit one of these online retailers:
http://www.randomhouse.com/catalog/display.pperl?isbn=9780307407900&ref=other_scribd-pdf-random-eterni-0210http://www.powells.com/biblio/62-9780307407900-0http://www.indiebound.org/book/9780307407900http://www.tkqlhce.com/click-2665379-10568661?url=http://www.borders.com/online/store/TitleDetail?sku=030740790X&cmpid=pub-rh-56http://search.barnesandnoble.com/Eternity-Soup/Greg-Critser/e/9780307462503&afsrc=1&lkid=J28248944&pubid=K124596&byo=1http://www.amazon.com/Eternity-Soup-Inside-Quest-Aging/dp/030740790X?tag=randohouseinc2-20