Embed Size (px)
Citation preview
ERS SHORT-TERM RESEARCH TRAINING FELLOWSHIP
FREGONEZI Guilherme
Fellowship Number STRTF 24 - 2010
ERS SHORT-TERM RESEARCH TRAINING FELLOWSHIPS APPLICATION
No. STRTF 24-2010 – Prof. Guilherme FREGONEZI Section 1 – Fellowship Sought Fellowship number: STRTF 24-2010
Title of proposed project: Strategies of breathing and Dynamic Hyperinflation during exercise in COPD
ERS Fellowship programme: STRTF
Keywords: Pursed Lips Breathing,Diaphragm breathing Dynamic hyperinflation, Optoelectronic Pletismography
Expected starting date: 01.03.2011
Expected finishing date: 01.06.2011
Do you intend to return home after the Fellowship?
Yes
What are you plans after the Fellowship?
The Universidade Federal do Rio Grande do Norte my home Institution has a recent acquire a Optoeletronic Pletismography equipment, this moment is important because Brazilian government has improve your financial support to research equipment. With this is a innovative technology that can help in diagnosis and determine the importance of some rehabilitation techniques, However, to operate the equipment is necessary training and technology transference. At the end of the short-term research training fellowship knowledge acquire will be help to implement an lung mechanics assessment Laboratory in public health system.
Section 2 – Applicant personal details Title:
Last name:
Prof.
FREGONEZI
First names: Guilherme
Gender Male
Date of birth: 29.01.1975
Nationality: BRAZIL
Present position: Full Profesor of Physical Therapy Department / Respiratory Performance Laboratory
Since when: 2006
Name and address of the home institution:
Physical Therapy Department / Respiratory Performance Laboratory Universidade Federal do Rio G. Norte Caixa Postal 1524 - Campus Universitário Lagoa Nova CEP 59072-970 Natal - RN - Brasil
Country: BRAZIL
Telephone: 55 84 33422013
E-mail: [email protected]
ERS membership number: 126573
Are you now based in your Home country?:
Yes
Home/Host address: Rua das Algarobas sn Apto 1402 Torre 2. Cond Parque Itatiaia, Bairro Cidade Verde- parnamirim CEP 59151907- Rn- Brazil
Section 3 – Home supervisor Title:
Last name:
Prof.
BRUNO
First names: Selma
Present position: Full Professor
Since when: 1994 Name and address of the home institution:
Departamento de Fisioterapia Centro de Ciências da Saúde - UFRN Campus Universitário Lagoa Nova Caixa Postal 1524 - CEP:59072-970-Natal-RN
Country: BRAZIL
Telephone: 55 84 33422013
E-mail: [email protected]
ERS member? No
ERS membership number: Section 4 – Host supervisor
Title:
Last name:
Dr.
ALIVERTI
First names: Andrea
Present position: Assistant Professor (Ricercatore Universitario)
Since when: 1998
Name and address of the home institution:
Dipartimento di Bioingegneria, Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133 Milano, Italy;
Country: ITALY
Telephone: 39 02 2399 9006
E-mail: [email protected]
ERS member? Yes
ERS membership number: 29618
Section 5 – Professional qualifications and experience of the applicant
Postdoctoral researcher since:
--
PhD holder since: 2005
MSc holder since 2003
MD holder since --
Other: Graduate in Physical Therapy - State University of Londrina - 1999. Neuroscience Specialist at Universitat Autònoma de Barcelona, 2001-2002. Master in Neuroscience at Universitat Autònoma de Barcelona?, 2002-2003. Promoter: Dr. Pere Casan Spécialise in Kinésithérapie Respiratoire et Cardio-Vasculaire, Université Renne- Descartes, Paris V, Paris 2003-2004, France. PhD in Neuroscience at Facultat de Medicina, Hospital de la Santa Creu i Sant Pau Universidad Autónoma Barcelona. Fellowship from National Research and Technology Council- Brazil, 2001-2005. Promoter: Dr. Pere Casan
List degrees/diplomas/field of study/ years in which obtained and name of institutes):
Graduate in Physical Therapy - State University of Londrina - 1999. Neuroscience Specialist at Universitat Autònoma de Barcelona, 2001-2002. Master in Neuroscience at Universitat Autònoma de Barcelona, 2002-2003. Promoter: Dr. Pere Casan Spécialise in Kinésithérapie Respiratoire et Cardio-Vasculaire, Université Renne- Descartes, Paris V, Paris 2003-2004, France. PhD in Neuroscience at Facultat de Medicina, Hospital de la Santa Creu i Sant Pau Universidad Autónoma Barcelona. Fellowship from National Research and Technology Council- Brazil, 2001-2005. Promoter: Dr. Pere Casa
Number of years fulltime research experience
10
Please provide other information on your research experience (part time, full time, while working, while studying, etc.)
Full Professor at Physical Therapy Department- Health Science Center Federal University of Rio Grande do Norte
Number of years professional experience (list: years, position, name of employer)
Profesor and Research since 2006 until now. Research at al de la Santa Creu i Sant Pau Universidad Autónoma Barcelona Clinical reserach from 2001 to 2005.
Last two positions:
Position 1
Name of employer
From-To:
Full Professor
Federal University of Rio Grande do NOrte
2006 to now
Position 2
Name of employer
From-To:
researcher
Hospital de la Santa Creu i Sant Pau Universidad Autónoma Barcelona?
2000-2005
Do you have 1 first author publication:
Yes - 1.FREGONEZI, GAF ; RESQUETI, V. R. ; Guell, M. R. Pursed lips breathing. Archivos de Bronconeumología, Espanha, v. 40, n. 6, p. 279-282, 2004. 2.FREGONEZI, GAF ; RESQUETI, Vanessa ; Guell, M. R. ; Pradas, J. ; CASAN, Pere . Effects of 8-week, Interval-Based Inspiratory Muscle Training and Breathing Retraining in Patients with Generalized Myasthenia Gravis. Chest, USA, v. 128, p. 1524-1530, 2005. 3FREGONEZI, GAF ; RESQUETI, V. R. ; Pradas, J. ; VIGIL, Laura ; CASAN, Pere . Domiciliary respiratory muscle training in myotonic dystrophy.Archivos de Bronconeumología, ESPAÑA, v. 42, p. 218-224, 2006. 4.FREGONEZI, GAF ; RESQUETI, Vanessa ; Pradas, J. ; VIGIL, Laura ; CASAN, Pere . The relationship between lung function and health-related quality of life in patients with generalized myasthenia gravis. Archivos de Bronconeumología, España, v. 42, n. 5, p. 218-224, 2006. 5.Fregonezi, GAF ; Resqueti, V. ; Ferreira, S. ; LIMA, A. P. Use of an inelastic bandage as an daptation of the lymphatic Drainage technique in lower limbs. BMJ Case Reports, v. 2009, p. bcr0620080050-bcr0620080050, 2009. 6.Fregonezi, Guilherme A. F. ; Azevedo, Ingrid G. ; Araujo, Thaise L. ; Dias, Fernando A. L. ; Resqueti, Vanessa R. Adaptation of the Threshold IMT with double spring load allows higher inspiratory pressure for muscle training. Clinical Physiology and Functional Imaging, v. 29, p. 462-464, 2009. 7.FREGONEZI, GAF ; RESQUETI, V. R. . Inspiratory muscle training in COPD where we are?. Respirology (Carlton South), v. 12, p. 937-938, 2007.-
Section 6 – ERS Fellowship application details Number of publications in international peer-reviewed periodicals as per date of this application
In English: 10
In other language: 3
Professional societies or associations of which you are a member:
ERS, SEPAR, Brazilian Physiology Society
Guilherme A F Fregonezi – Applicant
PROFESSIONAL EDUCATION
Graduation at Physiotherapy‐ Universidade Estadual de Londrina (1999)
Master's Degree in Neuroscience‐ Universidad Autonoma de Barcelona (2003)
Specialist in “Kinesiotherapie Respiratoire et CardioVasculaire – Université Paris V – Rene Descartes
(2004)
Ph.D. In Neuroscience Universidad Autonoma de Barcelona (2005)
CURRENT POSITION
Associate professor of Physical Therapy and health Science in “Universidade Federal do Rio Grande
do Norte”
RESEARCH ACTIVITIES
Research field: Physical Therapy and Rehabilitation that include: 1)respiratory assessment and
rehabilitation in Chronic Respiratory Diseases and Neuromuscular Diseases; 2) Measurements of
Respiratory muscle electrical signs; 3) Rehabilitation of Vascular Diseases.
The research activities were support by National Council for Scientific and Technological
Development (CNPq) and National Coordination for research and Education (CAPES) inside the
research programs Research Productivity and research financial to Health Science that support the
follow projects wich Professor Guilherme was Coordinator:
1) Deployment of Network Multicentric study of kinematics of Torax.Projeto Funded by CAPES
through the National Program of Academic Cooperation NF‐New Frontiers Procad resources
with 116.353,64 euros (2010‐2014)
2) Implementation costs and benefits of a physical activity program for Chronic Obstructive
Pulmonary Disease: Application of Primary Health Centres in the SUS. Financial support
Edital MCT / CNPq 14/2009 ‐ Universal 4.325,32 euros ( 2010‐2012);
3) Prevalence of signs and symptoms of PAD and neuropathy in diabetic patients seen by
national health care system in the city of Natal. Sub‐ Coordinator. Funded 011/2009 III
FAPERN PPSUS ( Brazilian Health Care System) 12,861,33 euros (2010‐2012);
4) Treatment of wounds and burns with carboxymethylcellulose dressings: a systematic review
of randomized controlled trials with meta‐analysis. Financial support CNPq and Brazilian
Health Care System 33,520.47 euros ( 2010‐2011);
TEACHING ACTIVITIES
Physical Therapy Graduated Course – since 2006‐ actual
Master degree Program in Physical Therapy – since 2007‐ actual
HONOURS AND AWARDS
2010 Silver Sponsorship to the European Respiratory Annual Congress, European Respiratory
Society.
2007 Bronze Sponsorship to the European Respiratory Annual Congress, European Respiratory
Society (ERS).
2005 Allied Respiratory Professionals Congress Travel Grants to attend European Respiratory
Annual Congress, Allied Respiratory Professionals Assembly ‐ European Respiratory Society (ERS).
2004 ERS Young Scientist Sponsorship European Respiratory Annual Congress, European
Respiratory Society (ERS).
2003 Young Investigators Award 2nd Prize European Respiratory Annual Congress, European
Respiratory Society (ERS).
1999 Award Graduate Scientific Research ‐ third best abstract, “Universidade do Norte do Parana‐
UNOPAR”.
GUILHERME A F FREGONEZI – Applicant
LIST of PUBLICATIONS
Original Peer‐reviwed
1. Severino FG, Resqueti VR,Bruno SS, Azevedo IG, Gurgel RH, Fregonezi, GAF . Comparison
between a national and a foreign manovacuometer for nasal inspiratory pressure measurement.
Brazilian Jorunal of Physical Therapy, 2010 ( In press).
2. ARAUJO TL, Resqueti VR, Bruno SS, Azevedo IG, Dourado Junior ME, Fregonezi GAF. Respiratory
muscle strength and quality of life in myotonic dystrophy patients. Revista Portuguesa de
Pneumologia, v. 16, p. 892‐898, 2010.
3. Jácome Gonçalves M, do Lago ST, de Paiva Godoy E, de Freitas Fregonezi GAF, Sousa Bruno S
Influence of Neck Circumference on Respiratory Endurance and Muscle Strength in the Morbidly
Obese.Obes Surg. 2010 Feb 3. [Epub ahead of print]
4. Fregonezi GA, Azevedo IG, Araujo TL, Dias FA, Resqueti VR. Adaptation of the Threshold IMT
with double spring load allows higher inspiratory pressure for muscle training. Clin Physiol Funct
Imaging. 2009 Nov;29(6):462‐4. Epub 2009 Aug 4
5. Resqueti VR, Oliveira GWS, Dourado JuniorME, Andrade A D, Casan P, Fregonezi GAF.
Confiabilidade do teste da caminhada de seis minutos em pacientes com miastenia gravis
generalizada. Fisioterapia e Pesquisa, v. 16, p. 223‐228, 2009.
6. de Freitas Fregonezi GA, Resqueti VR, Casan P. Domiciliary respiratory muscle training in
myotonic dystrophy. Arch Bronconeumol. 2006 Nov;42(11):605‐7
7. Fregonezi GA, Regiane‐Resqueti V, Pradas J, Vigil L, Casan P. The relationship between lung
function and health‐related quality of life in patients with generalized myasthenia gravis. Arch
Bronconeumol. 2006 May;42(5):218‐24.
8. Fregonezi GA, Resqueti VR, Güell R, Pradas J, Casan P. Effects of 8‐week, interval‐based
inspiratory muscle training and breathing retraining in patients with generalized myasthenia gravis.
Chest. 2005 Sep;128(3):1524‐30. Erratum in: Chest. 2005 Nov;128(5):3779.
Review articles and letter to editor
9FREGONEZI GAF, RESQUETI VR, Inspiratory muscle training in COPD where we are?. Respirology
(Carlton South), v. 12, p. 937‐938, 2007.
10. Fregonezi GA, Resqueti VR, Güell Rous R. Pursed lips breathing. Arch Bronconeumol. 2004
Jun;40(6):279‐82.
Meeting abstracts
1. Fregonezi, GAF ; Araujo, Thaise L. ; Azevedo, Ingrid G. ; Gurgel, R., H. ; SEVERINO, F. G. ; Dornelas
de Andrade, A. F. D. ; Resqueti, Vanessa R. . Maximal voluntary ventilation: dynamic compliance
and determinants in healthy subjects. In: XIV European Respiratory Society Annual Congress, 2009,
Viena. European Respiratory journal. Wakefield : The Charlesworth Group, 2009. v. 34.
2. Fregonezi, GAF ; Azevedo, Ingrid G. ; Gurgel, R., H. ; SEVERINO, F. G. ; Dornelas de Andrade, A. F.
D. ; Resqueti, Vanessa R. . Maximal voluntary ventilation: determination of respiratory pressure
developed in health subjects. In: XIV European Respiratory Society Annual Congress, 2009, Viena.
European Respiratory journal. England : Wakefield, 2009. v. 34.
3. Fregonezi, GAF ; SEVERINO, F. G. ; Tavares, JB ; Azevedo, Ingrid G. ; Dornelas de Andrade, A. F. D.
; Resqueti, Vanessa R. . Use of face mask adaptation to evaluated sniff nasal inspiratory pressure
and maximal respiratory pressure in healthy young. In: XIV European Respiratory Society Annual
Congress, 2009, Viena. European Respiratory journal. England : The Charlesworth Group, 2009. v.
34.
4. Arruda, R ; Paiva D ; Vieira F ; Marinho P ; Alcoforado L ; Dornelas de Andrade, A. F. D. ;
Fregonezi, GAF . Analysis of heating and humidification provided to patients after coronary artery
bypass surgery using an in‐line heat and moisture exchanger and heater‐water humidifier. In: XIV
European Respiratory Society Annual Congress, 2009, Viena. European Respiratory journal.
England : The Charlesworth Group, 2009. v. 34.
5. FREGONEZI, GAF ; Resqueti, Vanessa R. ; Araujo, Thaise L. ; Dornelas de Andrade, A. F. D. ;
Dourado Junior, ME . Reliability of the 6 minutes walking test (6MWT) in generalized myasthenia
gravis. In: XIV European Respiratory Society Annual Congress, 2009, Viena. European Respiratory
journal. Wakefield : The Charlesworth Group, 2009. v. 34.
6. Fregonezi, GAF ; Araujo, Thaise L. ; Azevedo, Ingrid G. ; Gurgel, R., H. ; Dourado Junior, ME ;
Dornelas de Andrade, A. F. D. ; Resqueti, Vanessa R. . Sniff nasal inspiratory pressure, maximal
respiratory pressures and quality of life in myotonic muscular distrophy. In: XIV European
Respiratory Society Annual Congress, 2009, Viena. European Respiratory journal. Wakefield : The
Charlesworth Group, 2009. v. 34.
7. Galindo Filho V ; Rodrigues Machado MG ; Brandão D ; Alcoforado L ; Galvão AM ; Fregonezi,
GAF ; Marinho P ; Dean E ; Dornelas de Andrade, A. F. D. . Coupling of noninvasive mechanical
ventilation and nebulization during asthma exacerbations: higher amount of aerosol deposition
into the airways or effective mechanical brochodilation due to positive pressure?. In: XIV European
Respiratory Society Annual Congress, 2009, Viena. European Respiratory journal. Wakefield : The
Charlesworth Group, 2009. v. 34.
8. Paiva D ; Alcoforado L ; Travassos E ; Arruda, R ; Advincula J ; Brandão D ; Marinho P ; Fregonezi,
GAF ; Galindo Filho V ; Dornelas de Andrade, A. F. D. . Comparative bacteriological study between
heat moisture exchanger filter and heated‐water humidifier and identification of infectious
pulmonary comorbidity in patients submitted to mechanical ventilation. In: XIV European
Respiratory Society Annual Congress, 2009. European Respiratory journal. Wakefield : The
Charlesworth Group. v. 34.
9. Lima I ; Ribeiro A ; Brandão D ; Alcoforado L ; Galindo Filho V ; Galvão AM ; Fregonezi, GAF ;
Marinho P ; Dornelas de Andrade, A. F. D. . Effects of hemiplegy in pulmonary function and
diaphragmatic domes displacement. In: XIV European Respiratory Society Annual Congress, 2009,
Viena. European Respiratory journal. Wakefield : The Charlesworth Group, 2009. v. 34.
10. Brandão D ; Galindo Filho V ; Pessoa M ; Barros R ; Silva T ; Fregonezi, GAF ; Alencar W ; Britto
M ; Dornelas de Andrade, A. F. D. . Effectiveness of nebulizing heliox coupled to bronchodilators
and body positioning in severe asthma patients. In: XIV European Respiratory Society Annual
Congress, 2009, Viena. European Respiratory journal. Wakefield : The Charlesworth Group, 2009. v.
34.
11. Alencar W ; Campelo A ; Mousinho R ; Brandão D ; Fregonezi, GAF ; Dornelas de Andrade, A. F.
D. . The impact of different peep values on intracranial pressure, cerebral perfusion pressure and
arterial pressure. In: XIV European Respiratory Society Annual Congress, 2009, Viena. European
Respiratory journal. Wakefield : The Charlesworth Group, 2009. v. 34.
12. CASTRO, L. P. L. B. ; Lago, STS ; Gonçalves, M., J. ; Fregonezi, GAF ; BRUNO, S. . Avaliação do
TC6M em obesos considerando a distribuição de gordura corporal. In: XIV Simpósio Internacional
de Fisioterapia Respiratória e Fisioterapia em Terapia Intensiva, 2008, Recife. Revista Brasileira de
Fisioterapia (Brazilian Journal of Physical Therapy). Sao Paulo : Zeppelini Editorial, 2008. v. 12 Sup.
p. 109‐109.
13. CASTRO, L. P. L. B. ; Lago, STS ; Gonçalves, M., J. ; Fregonezi, GAF ; BRUNO, S. . Comportamento
da FCmáx durante o TC6M em obesos grau III e IV. In: XIV Simpósio Internacional de Fisioterapia
Respiratória e Fisioterapia em Terapia Intensiva, 2008, Recife. Revista Brasileira de Fisioterapia
(Brazilian Journal of Physical Therapy). Sao Paulo : Zeppelini Editorial, 2008. v. 12 Sup. p. 109‐109.
14. CASTRO, L. P. L. B. ; Lago, STS ; Gonçalves, M., J. ; Fregonezi, GAF ; BRUNO, S. . Perfi l do grupo
de obesos pertencente ao ambulatório de tratamento da obesidade da HUOL entre 2007 e 2008.
In: XIV Simpósio Internacional de Fisioterapia Respiratória e Fisioterapia em Terapia Intensiva,
2008, Recife. Revista Brasileira de Fisioterapia (Brazilian Journal of Physical Therapy). Recife :
Zeppelini Editorial, 2008. v. 12 Sup. p. 115‐115.
15. Gonçalves, M., J. ; GOMES, P. I. P. G. ; Lago, STS ; Fregonezi, GAF ; BRUNO, S. . Avaliação da
função pulmonar durante pré e pósoperatório de cirurgia bariátrica. In: XIV Simpósio Internacional
de Fisioterapia Respiratória e Fisioterapia em Terapia Intensiva, 2008, Recife. Revista Brasileira de
Fisioterapia (Brazilian Journal of Physical Therapy)/. Sao Paulo : Zeppelini Editorial, 2008. v. 12 Sup.
p. 116‐116.
16. Gonçalves, M., J. ; Lago, STS ; CASTRO, L. P. L. B. ; Fregonezi, GAF ; BRUNO, S. . Análise da força
muscular respiratória em idosos com e sem sinais de SAOS. In: XIV Simpósio Internacional de
Fisioterapia Respiratória e Fisioterapia em Terapia Intensiva, 2008, Recife. Revista Brasileira de
Fisioterapia (Brazilian Journal of Physical Therapy). Sao Paulo : Zeppelini Editorial, 2008. v. 12 Sup.
p. 119‐119.
17. Gonçalves, M., J. ; Lago, STS ; CASTRO, L. P. L. B. ; Fregonezi, GAF ; BRUNO, S. . Comportamento
das variáveis espirométricas entre os obesos com e sem sinais de SAOS. In: XIV Simpósio
Internacional de Fisioterapia Respiratória e Fisioterapia em Terapia Intensiva, 2008, Recife. Revista
Brasileira de Fisioterapia (Brazilian Journal of Physical Therapy). Sao Paulo : Zeppelini Editorial,
2008. v. 12 Sup. p. 122‐122.
18. RESQUETI, V. R. ; AZEVEDO, I. G. ; Gurgel, R., H. ; BRUNO, S. ; FREGONEZI, GAF . Adaptação do
manuvacuômetro digital MVD300 para a manobra de pressão inspiratória nasal. In: XIV Simpósio
Internacional de Fisioterapia Respiratória e Fisioterapia em Terapia Intensiva, 2008, Recife. Revista
Brasileira de Fisioterapia (Brazilian Journal of Physical Therapy). Sao Paulo : Zeppelini Editorial,
2008. v. 12 Sup. p. 113‐113.
19. ARAUJO, T. L. ; AZEVEDO, I. G. ; RESQUETI, V. R. ; BRUNO, S. ; FREGONEZI, GAF . Força muscular
respiratória e qualidade de vida na distrofi a de Steinert. In: XIV Simpósio Internacional de
Fisioterapia Respiratória e Fisioterapia em Terapia Intensiva, 2008, Recife. Revista Brasileira de
Fisioterapia (Brazilian Journal of Physical Therapy). Sao Paulo : Zeppelini Editorial, 2008. v. 12 Sup.
p. 113‐113.
20. ARAUJO, T. L. ; AZEVEDO, I. G. ; RESQUETI, V. R. ; BRUNO, S. ; FREGONEZI, GAF . Evolução das
pressões respiratórias máximas na distrofi a de Steinert. In: XIV Simpósio Internacional de
Fisioterapia Respiratória e Fisioterapia em Terapia Intensiva, 2008, Recife. Revista Brasileira de
Fisioterapia (Brazilian Journal of Physical Therapy). Sao Paulo : Zeppelini Editorial, 2008. v. 12 Sup.
p. 113‐113.
21. FREGONEZI, GAF ; ARAUJO, T. L. ; Gurgel, R., H. ; RESQUETI, V. R. ; BRUNO, S. . Comparison of
controlled breathing and free breathing submaximal inspiratory endurance test in health
individuals. In: European Respiratory Society Annual Congress, 2008, Berlin. European Respiratory
Journal, 2008. v. 28. p. 727s‐727s.
22. FREGONEZI, GAF ; AZEVEDO, I. G. ; RESQUETI, V. R. ; BRUNO, S. . Adaptation of thethreshold
IMT with double spring load. In: European Respiratory Society Annual Congress, 2008, Berlin.
European Respiratory journal, 2008. v. 28. p. 726s‐726s.
23. FREGONEZI, GAF ; VIGIL, Laura ; RESQUETI, Vanessa ; BRUNO, S. ; CALAF, Nuria ; Casan, P. .
Comparison of VO2max from predicted equations with direct measured during exercise in COPD
patients. In: XVII European Respiratory Society Annual Congress, 2007, Estocolmo. European
Respiratory Journal. Wakefield : The Charlesworth Group, 2007. v. 30. p. 685s‐685s.
24. RESQUETI, Vanessa ; FREGONEZI, GAF ; BRUNO, S. ; CALAF, Nuria ; Casan, P. . Maximal
voluntary ventilation in myasthenia gravis: is the way to access respiratory muscle endurance?. In:
XVII European Respiratory Annual Congress, 2007, Estocolmo. European Respiratory Journal.
Wakefield : Charlesworth Group, 2007. v. 30. p. 239‐239.
25. BRUNO, S. ; SIlva JD ; FREGONEZI, GAF . Breathing pattern and postural changes in mouth
breathing syndrome childrens. In: XVII European Respiratory Society Annual Congress, 2007,
Estocolmo. European Respiratory Journal. Wakefield : The Charlesworth Group, 2007. v. 30. p.
239s‐239s.
26. FREGONEZI, GAF ; Mendonça APL ; FERREIRA, M. S. . AVALIAÇÃO DA CINTA ANELASTICA COMO
ADAPTAÇÃO NA TÉCNICA DE DLM EM LINFEDEMA DE MMII: RELATO DE CASO. In: XVII COBRAF ‐
Congresso Brasileiro de Fisioterapia, 2007, Sao Paulo. REvista Brasileira de Fisioterapia. Sao Carlos,
2007. v. 11. p. 168‐168.
27. VIGIL, Laura ; FREGONEZI, GAF ; RESQUETI, Vanessa ; CALAF, Nuria ; CODINA, Esperança ;
CASAN, Pere . Estimacion del VO2 max a partir de la frecuencia cardiaca máxima en pacientes con
enferemedad intersticial. In: XXXVIII Congreso Nacional de la Sociedad Española de Neumologia,
2005, Valencia. Archivos de Bronconeumologia. Valencia : DOYMA, 2005. v. 41. p. 141‐141.
28. FREGONEZI, GAF ; VIGIL, Laura ; RESQUETI, Vanessa ; CALAF, Nuria ; CODINA, Esperança ;
SOLANES, I. ; CASAN, Pere . Estimation of VO2máx through heart rate ratios method in COPD
patients.. In: XV European respiratory Annual congress, 2005, Copenhagem. European Respiratory
Journal, 2005. v. 26. p. 498s‐498s.
29. FREGONEZI, GAF ; VIGIL, Laura ; RESQUETI, Vanessa ; CALAF, Nuria ; CODINA, Esperança ;
SOLANES, I. ; CASAN, Pere . Consumo máximo de Oxigenio estimado en EPOC a partir de la relación
de frecuencia cardíaca máxima/basal durante el ejercício. In: XXXVIII Congreso Nacional de la
Sociedad Española de Neumología y Cirurgía Torácica, 2005, Valencia. Archivos de
bronconeumologia. Barcelona : DOYMA, 2005. v. 41. p. 40‐40.
30. FREGONEZI, GAF ; RESQUETI, V. R. ; Guell, M. R. ; Pradas, J. ; Casan, P. . Efectos del
entrenamiento a intervalos de los músculos inspiratorios asociado a ejercicios respiratorios en la
miastenia gravis. In: XXXVII Congresso Nacional de la SEPAR ( Sociedad Española de neumologia),
2004, Madrid. Archivos de Neumologia. Barcelona : Doyma, 2004. v. 40. p. 31‐32.
31. FREGONEZI, GAF ; RESQUETI, V. R. ; Guell, M. R. ; Pradas, J. ; Casan, P. . Sensation of dyspnea,
fatigue and respiratory effort does not influence 6MWD in MG. In: 14th Annual European
Respiratory Congress, 2004, Glasgow. European Respiratory Journal, 2004. v. 24. p. 405s‐405s.
32. FREGONEZI, GAF ; RESQUETI, V. R. ; Guell, M. R. ; Pradas, J. ; Casan, P. . Health‐related quality
of life in myasthenia gravis patients and its correlation with respiratory function.. In: 14th Annual
European Respiratory Congress, 2004, Glasgow. European Respiratory Journal, 2004. v. 24. p. 405s‐
405s.
33. RESQUETI, V. R. ; GOROTIZA, A. ; SANGENIS, M. ; SANTA MARIA, E. L. ; FREGONEZI, GAF ;
GALDIZ, J. B. ; Casan, P. ; Guell, M. R. . Nine‐weeks home respiratory rehabilitation in severe COPD
patients‐ Preliminary Results. In: 14th Annual European Respiratory Congress, 2004, Glasgow.
European Respiratory Journal, 2004. v. 24. p. 633s‐633s.
34. FREGONEZI, GAF ; Guell, M. R. ; Pradas, J. ; Casan, P. . Effects of Inspiratory muscle training
program in generalized myasthenia gravis. In: European Respiratory Society Annual Congress, 2003,
Vienna‐ Austria. European Respiratory Journal, 2003. v. 22. p. 426s‐426s.
35. FREGONEZI, GAF ; RESQUETI, V. R. . Respiração em freno‐labial: estado atual do tema. In: XVIII
Congresso de Pneumologia Portuguesa, II Congresso Luso‐Brasileiro de Pneumologia, 2002, Porto‐
Portugal. Revista Portuguesa de Pneumologia. Lisboa : Publicação Ciencia e Vida, 2002. v. VIII. p.
507‐507.
Project
Strategies of breathing and Dynamic Hyperinflation during exercise in COPD
Project description submitted for consideration for ERS Short-Term Research Training Fellowships 2010
Applicant: Guilherme A F Fregonezi Host Supervisor: Prof. Andrea Aliverti
Project summary The aim of this project is to evaluate the effects of different breathing
strategies (pursed-lip breathing, diaphragmatic breathing and use of positive
endexpiratory pressure) on dynamic hyperinflation in COPD during incremental
exercise testing.
The researchers plan to enroll and study 8-12 COPD patients (estimated
sample size) using spirometry and incremental exercise testing associated
with optoelectronic plethysmography. All patients will be submitted to the
two incremental exercise tests described below. The first exercise test will be
used to establish dynamic hyperinflation and chest wall volume regulation at
baseline. The remaining incremental exercise tests will involve the use of
three randomize different breathings, namely pursed-lip breathing,
diaphragmatic breathing and use of positive end expiratory pressure.
The host selection, “Laboratorio di Tecnologie biomediche, Dipartimento di
Bioingegneria, Politecnico di Milano University ” is a public institution dedicated
to scientific research in the fields of Biomedical Engineering, as well as to the
formation of highly qualified investigators in these areas. The production of
knowledge, as well as the laboratory and research groups, are internationally
respected. The current technology used in this project (optoelectronic
plethysmography) was developed by Prof. Dr. Andrea Aliverti and his group.
Professor Aliverti has trained researchers and has led his group in the study of
important topics within bioengineering of the respiratory system, including the
mechanics of breathing and exercise in COPD.
The respiratory laboratory of the “Universidade Federal do Rio Grande do Norte
is linked to the Doctoral Program in Health Sciences, which has recently
acquired an optoelectronic plethysmography system to study the implication
of lung volume in chronic pulmonary disease during exercise and use of
respiratory rehabilitation techniques. Furthermore, this new technology can be
implemented for long-term care in the public health system. This mechanism
can also be useful in treating other chronic diseases, such as obesity and
neuromuscular disease. The ERS Fellowship will improve the ability of the
applicant to develop and design research in the field of respiratory medicine .
Research Aim and Specific Objectives The aim of this proposal is to evaluate the effects of different breathing
strategies on dynamic hyperinflation -in COPD patients. COPD, a slowly
progressing chronic respiratory disorder, is characterized by a rarely reversible
obstructive ventilatory pattern very often related to tobacco smoking and
which can lead to chronic respiratory failure1. Exercise limitation in COPD
patients is related to a number of physiopathological mechanisms. In the last
year dynamic hyperinflation has gained importance in the study of exercise
limitation and it has been shown that it is one of the factors limiting exercise in
these patients On the other hand, some rehabilitative exercises used in
physiotherapy have the potential for decreasing volume, specifically end-
expiratory lung volume 2.
This proposal will take advantage of the experience of the host group in the
mechanics of breathing and exercise. The innovations of the project include the
study of different breathing strategies during exercise using continuous
analysis of optoelectronic plethysmography.
Aim: To evaluate the effects of different breathing strategies on dynamic
hyperinflation in COPD patients during incremental exercise testing using
optoelectronic plethysmography.
Objective 1: To evaluate the effectiveness of different breathing exercise
strategies: pursed-lip breathing , diaphragmatic breathing and the use of
positive end expiratory pressure to decrease end expiratory lung volume
Objective 2: To determine which breathing strategies can improve exercise
performance and decrease end expiratory lung volume.
Data from this study, which will be collected at the Istituto di Ricovero e Cura-
INRCA – Casatenovo - Lecco will be used to design and implement physical
therapy exercises to improve rehabilitation outcomes techniques.
Background Exercise limitation is a common characteristic in most patients with COPD
and progressive dynamic hyperinflation, which is closely linked to shortness of
breath, is the main phenomenon responsible for this limitation. 3.
During exercise, most patients with COPD exhibit a rapid and short
breathing pattern4 that is strongly related to CO2 retention5-11. Therefore,
modulating respiratory pattern using different breathing strategies during
exercise could influence exercise behavior. Some of the techniques used by
respiratory physical therapy, such as respiratory exercises (pursed-lip
breathing and diaphragmatic breathing)4,12-14 and positive expiratory end
pressure (PEEP)15,16, have physiological characteristics capable of modulating
respiratory pattern during exercise, thereby improving gas exchanges and
reducing hyperinflation. However, results to date have not assessed the main
marker of dynamic hyperinflation: end-expiratory lung volume (EELV). End-
expiratory lung volume is an important outcome in assessing the effects of
therapeutic interventions on the development of dynamic hyperinflation during
exercise 17-19.
Detailed Research Plan
Activities/Period* 1 2 3 4 5 6
Preparation and training techniques X Recruitment & screening X
Baseline testing, spirometry and first incremental exercise test
X
Training in breathing techniques X
Second incremental exercise test X
Third incremental exercise test X
Fourth incremental exercise test X
Conclusion, data analysis, evaluation, final reports, and publications.
X X X
* Each period corresponds to two weeks
Methods
In summary, the number of patients will be selected according to the
following formula n = 1.962 * s2/E2 ,where n represents sample size, 1.96 a
confidence interval of 95%, s the standard deviation of the reference study
(Aliverti et al 20) and E the error or lowest intergroup difference. The standard
deviation previously published in the reference study was adopted. This
corresponded to 277 ml in relation to dynamic hyperinflation measured by end
expiratory lung volume (EELV), assessed using electronic plethysmography and
the lowest intergroup difference of 80 to 100 ml (mean hyperinflation
measured by EELV during exercise, resulting in a sample of 8 to 12 patients).
Inclusion criteria will be patients diagnosed with COPD, with no clinical
history of bronchial asthma or worsened condition in the previous six months,
with no comorbidities that could limit incremental exercise on an ergometric
stationary bicycle. The use of short-acting and long-acting bronchodilator will
be suspended 4 and 12 hours, respectively, before exercise. Groups with
sample n between 24 and 36 patients will be submitted to basal evaluations
such as spirometry and anthropometric assessment. The experimental protocol
will also be analysed. The patients will be randomly divided into 3 groups:
pursed-lip breathing group, diaphragmatic breathing group and PEEP breathing
group (10% expiratory resistance). All the groups will be evaluated 3 times,
where kinematics of the thoracoabdominal complex will be studied, using
optoelectronic plethysmography. Evaluation 1: measure of tidal volume at rest;
evaluation 2: measure of tidal volume during symptoms-limited maximum
incremental test on an ergometric bicycle using one of the respiratory patterns
or of PEEP10 ; evaluation 3: measure of tidal volume after the use of
respiratory patterns or PEEP10 .
Facilities available at the home institution Upon returning, I will use the knowledge acquired to establish a research
group to study the different physical therapy breathing techniques applied to
lung mechanics and exercise limitation in chronic respiratory diseases. The
Physical Therapy Department of the Federal University of Rio Grande do Norte
inaugurated the PneumoCardioVascular Physical Therapy Laboratory in 2008
and has recently acquired an optoelectronic and gas analysis system to
enhance investigations of exercise limitation and breathing mechanics.
References 1.Raherison C and P-O. Girodet P-O. Epidemiology of COPD. Eur Respir Rev 2009; 18: 114,
213–221.
2. Ugalde V, Breslin EH, Walsh SA, Bonekat HW, Abresch Carter GT. Pursed lips breathing
improves ventilation in myotonic muscular dystrophy. Arch Phys Med Rehabil 2000;81:472-8.
3. Vogiatzis I, Georgiadou O, Golemati S, Aliverti A, Kosmas E, Kastanakis E, Geladas N,
Koutsoukou A, Nanas S, Zakynthinos S, Roussos C.Patterns of dynamic hyperinflation during
exercise and recovery in patients with severe chronic obstructive pulmonary disease.Thorax.
2005 Sep;60(9):723-9.
4. P.T. Macklem. Therapeutic implications of the pathophysiology of COPD,Eur Respir J 2010;
35: 676–680.
5.Nerini M, Bianchi R, Romagnoli I, et al. Non-invasive measurement of breathing pattern in
eucapnic and hypercapnic patients with COPD. Am J Resp Crit Care Med 2002; 165: A45.
6. Gigliotti F, Bianchi R, Duranti R, et al. Ventilatory determinants of Pa,CO2 in COPD. Eur
Respir J 2005; 26: Suppl. 49, 360s.
7. Javaheri S, Blum J, Kazemi H. Pattern of breathing and carbon dioxide retention in chronic
obstructive lung disease. Am J Med 1981; 71: 228–234.
8. Parot S, Miara B, Milic-Emili J, et al. Hypoxemia, hypercapnia, and breathing pattern in
patients with chronic obstructive pulmonary disease. Am Rev Respir Dis 1982; 126: 882–886.
9. Scano G, Spinelli A, Duranti R, et al. Carbon dioxide responsiveness
in COPD patients with and without chronic hypercapnia. Eur Respir J 1995; 8: 78–85.
10. Loveridge B, West P, Anthonisen NR, et al. Breathing patterns in patients with chronic
obstructive pulmonary disease. Am Rev Respir Dis 1984; 130: 730–733.
11. Rochester DF. Respiratory muscle weakness, pattern of breathing,
and CO2 retention in chronic obstructive pulmonary disease. Am Rev Respir Dis 1991; 145:
901–903.
12.Cahalin LP, Braga M, Matsuo Y, Hernandez ED. Efficacy of diaphragmatic breathing in
persons with chronic obstructive pulmonary disease: a review of the literature. J Cardiopulm
Rehabil. 2002 Jan-Feb;22(1):7-21.)
13.Visser FJ, Ramlal S, Dekhuijzen PN, Heijdra YF. Pursed-Lips Breathing Improves Inspiratory
Capacity in Chronic Obstructive Pulmonary Disease. Respiration. 2010.
14.Spahija J, Marchie M, Ghezzo H, Grassino ª Factors discriminating spontaneous pursed-lips
breathing use in patients with COPD.COPD. 2010 Aug;7(4):254-61.
15. Padkao T, Boonsawat W, Jones CU. Conical-PEP is safe, reduces lung hyperinflation and
contributes to improved exercise endurance in patients with COPD: a randomised cross-over
trial.J Physiother. 2010;56(1):33-9.
16.Borghi-Silva A, Mendes RG, Toledo AC, Malosá Sampaio LM, da Silva TP, Kunikushita LN,
Dutra de Souza HC, Salvini TF, Costa D. Adjuncts to physical training of patients with severe
COPD: oxygen or noninvasive ventilation?Respir Care. 2010 Jul;55(7):885-94.
17. Belman MJ, Botnick WC, Shin JW. Inhaled bronchodilators reduce dynamic hyperinflation
during exercise in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care
Med 1996;153:967–75.
18. O’Donnell DE, Bertley JC, Webb KA, et al. Mechanism of relief of exertional
breathlessness following unilateral bullectomy and lung volume reduction
surgery in advanced chronic airflow limitation. Chest 1996;110:18–27.
19. Dolmage TE, Waddell TK, Maltais F, et al. The influence of lung volume
reduction surgery on exercise in patients with COPD. Eur Respir J 2004;23:275–80.
20.A Aliverti, N Stevenson, R L Dellaca` , A Lo Mauro, A Pedotti, P M A CalverleyRegional chest
wall volumes during exercise in chronic obstructive pulmonary disease.Thorax 2004;59:210–
216.
Armele de Fátima Dornelas de Andrade
Fellow suport by National Research Council- Brasil
PROFESSIONAL EDUCATION
Graduation at Physiotherapy- Universidade Federal de Pernambuco (1983)
Master's Degree Physiology- Universidade Federal de Pernambuco (1988)
Ph.D. at Chimie de L Environment Option Santé Pneumoalergol by Universite
d'Aix-Marseille III (1995)
Postdoctoral Fellow University of British Columbia (2006)
CURRENT POSITION
Associate Professor of Physical Therapy – Universidade Federal do Rio Grande
do Norte
RESEARCH ACTIVITIES
Research field: Physical Therapy and Rehabilitation that include: 1)respiratory
rehabilitation in elderly and Chronic Respiratory Diseases; 2) Mesurements of
Respiratory muscle electrical signs; 3) Aerosol therapy.
The research activities were support by National Council for Scientific and
Technological Development (CNPq) and National Coordination for research and
Education (CAPES) inside the research programs Research Productivity and
research financial to Health Science that support the follow projects witch
Professor Armele was Coordinator:
1) Noninvasive ventilation associated with nebulization in acute asthma:
evaluation of pulmonary deposition of aerosols, spirometric parameters
and the level of exhaled nitric oxide;
2) Establishment of a multi-user laboratory evaluation of cardio pulmonary
system by Optoelectronic Plethysmography (OEP Optoelectronic
plethysmography) associated with Ergospirometry;
3) Abdominal muscle activity during use of the Valsalva maneuver in
different lung volumes in the third trimester of pregnancy;
4) Influence of respiratory muscle training and the degree of pulmonary
obstruction in patients with COPD and inspiratory muscle activity in
diaphragmatic excursion using different inspiratory loads;
5) Depressive symptoms and assessment of levels of TNF alpha and IL-2 in
elderly patients with COPD;
6) influence of different nebulized solutions on the effect of aerosol
distribution and airway;
All projects were support with grants that sums are approximately 600.000
euros.
TEACHING ACTIVITIES
Physical Therapy Graduated Course – since 1989- actual
PhD and Master degree Program in health Science – since 2002 – actual
Master degree Program in Physical Therapy – since 2007- actual
HONOURS AND AWARDS
2007 ERS Silver Sponsorship to attend European Respiratory Annual Congress
Stockolm, European Respiratory Society.
2006 13 International Congress of Respiratory Physical Therapy – Third best
abstract- National Association of Respiratory Physical Therapy.
2004 ERS Gold Sponsorship to attend European Respiratory Annual Congress
Glasgow, European Respiratory Society.
2003- actual Fellow suport by National Research Council- Brasil
ARMELE DE FÁTIMA DORNELAS DE ANDRADE – Home supervisor
LIST of PUBLICATIONS
10 most important/relevant
1. MARINHO, Patricia Érika de Melo ; Melo, K.P.B. ; APOLINÁRIO, A. D. ; Bezerra E. ; Freitas, J. ; MELO, D. M. ; GUERRA, Ricardo de Oliveira ; DORNELAS DE ANDRADE, Armele F. . Undertreatment of depressive symptomatology in the elderly. Archives of Gerontology and Geriatrics, v. 50, p. 151-155, 2010. 2. LEMOS, A. ; SOUZA, A. I. ; Figueiroa, J.N. ; CABRAL FILHO, J. E. ; DORNELAS DE ANDRADE, Armele F. . Respiratory muscle strength in pregnancy. Respiratory Medicine, v. on lin, p. on line-on line, 2010. 3. BRANDÃO, Daniela Cunha ; LIMA, V. M. ; GALINDO FILHO, V. C. ; SILVA, T. N. S. ; CAMPOS, T. F. ; DEAN, Elizabeth ; DORNELAS DE ANDRADE, Armele F. . Reversal of Bronchial Obstruction with Bilevel Positive Airway Pressure and Nebulization in Patients with Acute Asthma. The Journal of Asthma, v. 46, p. 356-361, 2009. 4. Guedes, L.U. ; PARREIRA, Verônica Franco ; DIÓRIO, A. L. M. ; Goulart, F.R.P. ; DORNELAS DE ANDRADE, Armele F. ; Britto, R.R. . Electromyographic activity of sternocleidomastoid muscle in patients with Parkinson s disease. Journal of Electromyography and Kinesiology, v. 19, p. 591-597, 2009. 5. Resqueti, V.R. ; Souza, G.W. ; Dourado Junior ; DORNELAS DE ANDRADE, Armele F. ; CASAN, P. ; FREGONEZI, G. A. F. . Confiabilidade do teste da caminhada de seis minutos em pacientes com miastenia gravis generalizada. Fisioterapia e Pesquisa, v. 16, p. 223-228, 2009. 6. DORNELAS DE ANDRADE, Armele F. ; NOBRE, Maria Elizabeth Pereira . Inspiratory muscle endurance testing: Pulmonary ventilation and electromyographic analysis. Respiratory Physiology and Neurobiology, Estados Unidos, v. 155, n. line, p. 41-48, 2007. 7. DORNELAS DE ANDRADE, Armele F. ; SILVA, T. N. S. ; NOBRE, Maria Elizabeth Pereira . Eletromyographic activity of respiratory muscles: The possibility of considering diaphragmatic EMG as an isolated signal. Respiratory Physiology and Neurobiology, v. 158, p. 3-5, 2007. 8. DORNELAS DE ANDRADE, Armele F. ; FRANÇA, E. E. T. ; CABRAL, Geovana ; ALMEIDA, Paulo ; SILVA, Thayse ; SILVA, Kamary Coriolano Lins da ; GALINDO FILHO, Valdecir Castor ; PARREIRA, Verônica Franco . Nebulization associated with bi-level noninvasive ventilation: analysis of pulmonary radioaerosol deposition. Respiratory Medicine, Estados Unidos, v. 100, p. 721-728, 2006.
9. DORNELAS DE ANDRADE, Armele F. ; SILVA, Thayse Neves Santos ; VASCONCELOS, Helga ; MORAES, Nelson H ; Marinho,PEM ; GALINDO FILHO, Valdecir Castor ; AMORIM, C. F. . Inspiratory Muscular activation during threshold therapy in elderly healthy and patients with COPD. Journal of Electromyography and Kinesiology, Estados Unidos, v. 15, p. 631-639, 2005. 10. DORNELAS DE ANDRADE, Armele F. ; CHARPIN, D. ; VERVLOET, D. ; LANTEAUME, A. ; PASCAL, L. ; DUTAU, H. ; ARMENGAUD, A. ; SAMBUC, R. . The prevalence of reported asthma is independent of exposure in house dust mite sensitized. The European Respiratory Journal, Inglaterra, v. 13, n. 5, p. 983-987, 2000.
Andrea Aliverti, Curriculum Vitae – Page 1
ANDREA ALIVERTI- CURRICULUM VITAE
Born in Como, Italy on 14 March 1966. Actual address: Via Mocchetti 23, Como, Italy. Married, 3 children
CURRENT POSITION
Associate Professor, Dipartimento di Bioingegneria, Politecnico di Milano, Italy
PROFESSIONAL EDUCATION
1992. Master Degree (Laurea) in Electronic Engineering. Politecnico di Milano
1997. PhD (Dottorato di Ricerca) in Biomedical Engineering. Politecnico di Milano. Thesis title: “Innovative
methods and techniques to study respiratory mechanics”.
RESEARCH ACTIVITIES
Research field: bioengineering of the respiratory system. Current areas of interest include: a) Development of
innovative methods for optoelectronic analysis of thoraco-abdominal kinematics and volumes during
respiration; b) Development of double body Plethysmography for measuring blood shifts from and to the trunk;
c) modelling of respiratory mechanics: functional models of the actions of respiratory muscles; rib cage
mechanics; measurement of the viscoelastic properties of the respiratory system; cardiopulmonary interactions
during exercise; d) Creating a deeper understanding of the physiology and pathophysiology of the respiratory
system in exercise; the effects of flow limitation on chest wall mechanics during exercise; the effects of
mechanical ventilation and anesthesia on thoraco-abdominal motion; electrical stimulation of respiratory
muscles; respiratory kinematics in pulmonary and neuromuscular disease; f) development of software and
hardware systems particularly with regard to measurement problems (volume, flow, pressure, gas
concentration and motion) of the respiratory system; development of new methods of respiratory mechanics
analysis based on the forced oscillation technique; development of new methods for the measurements of
oxygen consumption on a breath-by-breath basis; g) analysis of mono- and bi-dimensional physiologic signals,
in particular, the correlation between motion of the external thoraco-abdominal surface area with the internal
motion of the lung and diaphragm (measured by ultrasound); h) development of new methods for the
functional and morphometric analysis of healthy and emphysematous lung by Computed Tomography (CT).
The research activities were mainly carried out within the following research programs: MURST (Italian
Ministry of Research) program: “Respiratory mechanics: three dimensional analysis by optoelectronic
systems”, BREATH project: “Biomedical technology for Respiration Analysis Through optoelectronics.”
CARED project: “Computer Aided Rehabilitation of Respiratory Diseases. In all these three programs I was
Technical Coordinator.
Andrea Aliverti, Curriculum Vitae – Page 2
I am an active member of the ERS, where I am the Secretary of the group 4.03 ‘Respiratory Structure and
Function’.
On September 27-28, 2007 I chaired the ERS Research Seminar: “The Limits to Exercise in COPD: New
Insights from New Methods” (Como, Italy)
I was visiting scientist at the following Universities: McGill University, Canada (1994, 1995, 1996, 1999,
2002, 2006), University of Pennsyvania, Philadelphia, USA (2006, 2007, 2008, 2009), Washington University
in St Louis, USA (2004, 2007, 2009), University of Zurich, Svizzera (2006, 2007), University of Athens,
Grecia (2004, 2005, 2006, 2007, 2009), University of Uppsala, Svezia (2006, 2009)
I am currently doing collaborative research with the following Universities: McGill University, Montreal,
Canada (Prof. P.T. Macklem), Universitè de Geneve (Prof. B. Kayser), University of Liverpool (Prof. P.M.
Calverley), Saarland University, Homburg (Prof. G.W. Sybrecht), University of Athens (Proff. C. Roussos, I.
Vogiatzis, Zakhynthinos), Boston University (Proff. K. Lutchen, B. Suki), University of Pennsylvania (Prof.
J.D. Cooper), University of Uppsala (Prof. G. Hedenstierna), Washington University (Prof. J. Woods),
TEACHING AND OTHER DIDACTIC ACTIVITIES
From the academic year 2002-3 I am in charge of the course on “Technologies for Sensors and
Instrumentation” of the Laurea Program in Biomedical Engineering of the Politecnico di Milano
University.
From the academic year 2003-4 I am in charge of the integrated course on “Bioengineering of
Autonomic Control and Respiratory Systems” of the Laurea Specialistica Program in Biomedical
Engineering of the Politecnico di Milano University.
In 2001 I was organizer and lecturer of the post-graduate course “What is new in mechanics of
breathing: implications for diagnosis and treatment” financed by the European Community
Since 1993 I supervised or co-supervised 58 Laurea Theses in Biomedical Engineering or Electronic
Engineering at the Politecnico di Milano (Faculty of Engineering) of 67 students.
HONOURS AND AWARDS
2005 - Selected young investigator of the European Respiratory Society (ERS) for the Annual Meeting of the
Japanese Respiratory Society (JRS)
2004 – Winner of the 2nd prize (20,000 €) of the “ERS (European Respiratory Society) - COPD Award 2004”
1998 – Winner of the Prize Paolo Durst, Microtec, from the Interdisciplinary Centre of Bioengineering,
Università di Padova, for the best Italian PhD thesis in Biomedical Engineering .
ANDREA ALIVERTI Host supervisor
LIST of PUBLICATIONS
10 most important/relevant
1. Aliverti A, Uva B, Laviola M, Bovio D, Lo Mauro A, Tarperi C, Colombo E, Loomas B, Pedotti A,
Similowski T, Macklem PT. Concomitant ventilatory and circulatory functions of the diaphragm and
abdominal muscles. J Appl Physiol. 2010 Sep 2. [Epub ahead of print]
2. Wilkens H, Weingard B, Lo Mauro A, Schena E, Pedotti A, Sybrecht GW, Aliverti A. Breathing
pattern and chest wall volumes during exercise in patients with cystic fibrosis, pulmonary fibrosis
and COPD before and after lung transplantation. Thorax. 2010 Sep;65(9):808‐14.
3. Romei M, Mauro AL, D'Angelo MG, Turconi AC, Bresolin N, Pedotti A, Aliverti A. Effects of gender
and posture on thoraco‐abdominal kinematics during quiet breathing in healthy adults. Respir
Physiol Neurobiol. 2010 Jul 31;172(3):184‐91.
4. Aliverti A, Kayser B, Cautero M, Dellacà RL, di Prampero PE, Capelli C. Pulmonary V(O)(2) kinetics at
the onset of exercise is faster when actual changes in alveolar O2 stores are considered. Respir
Physiol Neurobiol. 2009 Oct 31;169(1):78‐82.
5. Aliverti A, Bovio D, Fullin I, Dellacà RL, Lo Mauro A, Pedotti A, Macklem PT. The abdominal
circulatory pump. PLoS One. 2009;4(5):e5550. Epub 2009 May 14.
6. Aliverti A, Quaranta M, Chakrabarti B, Albuquerque AL, Calverley PM. Paradoxical movement of the
lower ribcage at rest and during exercise in COPD patients. Eur Respir J. 2009 Jan;33(1):49‐60.
7. Aliverti A. Lung and chest wall mechanics during exercise: effects of expiratory flow limitation.
Respir Physiol Neurobiol. 2008 Nov 30;163(1‐3):90‐9.
8. Aliverti A, Macklem PT. Last Word on Point:Counterpoint: The major limitation to exercise
performance in COPD is 1) inadequate energy supply to the respiratory and locomotor muscles, 2)
lower limb muscle dysfunction, 3) dynamic hyperinflation. J Appl Physiol. 2008 Aug;105(2):763.
9. Aliverti A, Rodger K, Dellacà RL, Stevenson N, Lo Mauro A, Pedotti A, Calverley PM. Effect of
salbutamol on lung function and chest wall volumes at rest and during exercise in COPD. Thorax.
2005 Nov;60(11):916‐24.
10. Aliverti A, Kayser B, Macklem PT. Breath‐by‐breath assessment of alveolar gas stores and exchange.
J Appl Physiol. 2004 Apr;96(4):1464‐9.
11. Aliverti A, Iandelli I, Duranti R, Cala SJ, Kayser B, Kelly S, Misuri G, Pedotti A, Scano G, Sliwinski P,
Yan S, Macklem PT. Respiratory muscle dynamics and control during exercise with externally
imposed expiratory flow limitation. J Appl Physiol. 2002 May;92(5):1953‐63.
12. Aliverti A, Cala SJ, Duranti R, Ferrigno G, Kenyon CM, Pedotti A, Scano G, Sliwinski P, Macklem PT,
Yan S. Human respiratory muscle actions and control during exercise. J Appl Physiol. 1997
Oct;83(4):1256‐69.
