Embed Size (px)
Citation preview
ERS SHORT-TERM RESEARCH TRAINING FELLOWSHIP
SHAH Naveed Nazir
Fellowship Number STRTF 153-2010
ERS SHORT-TERM RESEARCH TRAINING FELLOWSHIPS APPLICATION
No. STRTF 153-2010 – Dr. Naveed Nazir SHAH Section 1 – Fellowship Sought
Fellowship number: STRTF 153-2010
Title of proposed project: TRADITIONAL TBNA vs EBUS GUIDED TBNA IN THE LUNG CANCER STAGING AND IN THE DIAGNOSIS OF MEDIASTINAL LESIONS: a prospective randomized study
ERS Fellowship programme: STRTF
Keywords: transbronchial needle aspiration, endobronchial ultrasound, lung cancer,mediastinum
Expected starting date: 01.04.2011
Expected finishing date: 30.06.2011
Do you intend to return home after the Fellowship?
Yes
What are you plans after the Fellowship?
Our hospital has been upgraded to the level of an institute with the facilities of video bronchoscope with accessories, video-thoracoscope, rigid bronchoscope with the accessories and polysomnography. So we are having all the facilities of starting interventional pulmonology in our department and we plan to start a separate unit of interventional pulmonology on completion of the training.
Section 2 – Applicant personal details
Title:
Last name:
Dr.
SHAH
First names: Naveed Nazir
Gender Male
Date of birth: 04.09.1978
Nationality: INDIA
Present position: lecturer/consultant
Since when: 2008
Name and address of the home institution:
Department Of Chest Medicine, Government Medical College, Srinagar, J&K
Country: INDIA
Telephone: 91
E-mail: [email protected]
ERS membership number: 158626
Are you now based in your Home country?:
Yes
Are you now based in your Host country?:
No - INDIA
Home/Host address: Opposite Bhaba Atomic Research Centre, Zakoora, Srinagar, J&K, India. 190006
Since Section 3 – Home supervisor
Title:
Last name:
Prof.
MIRZA
First names: Mohammad Muzaffar
Present position: PROFESSOR AND HEAD OF DEPARTMENT
Since when: 2006 Name and address of the home institution:
DEPARTMENT OF CHEST MEDICINE, CHEST DISEASES HOSPITAL(GOVERNMENT MEDICAL COLLEGE, DRUGJAN, SRINAGAR,J&K,INDIA 190001
Country: INDIA
Telephone: -9797019913
Fax: -2422486
E-mail: [email protected]
ERS member? No
ERS membership number: Section 4 – Host supervisor
Title:
Last name:
Prof.
GASPARINI
First names: Stefano
Present position: DIRECTOR
Since when: JUNE 2000
Name and address of the home institution:
Head Respiratory Diseases Unit Department of Internal Medicine, Immunoallergic and Respiratory Diseases Azienda Ospedaliero-Universitaria 'Ospedali Riuniti' Via Conca, 60020 Ancona, Italy
Country: ITALY
Telephone: +39 071 5965694,
Fax: +39 071 5964344
E-mail: [email protected]
ERS member? Yes
ERS membership number: 9171
Section 5 – Professional qualifications and experience of the applicant
Postdoctoral researcher since:
2007
PhD holder since: --
MSc holder since --
MD holder since 2007
List degrees/diplomas/field of study/ years in which obtained and name of institutes):
MBBS Jawahar Lal Nehru Medical College, AMU, Aligarh. 2003 MD Tuberculosis & Respiratory Diseases , Jawahar Lal Nehru Medical College, AMU,Aligarh. 2007.
Number of years fulltime research experience
6
Please provide other information on your research experience (part time, full time, while working, while studying, etc.)
Thesis work done on ?Role of Bronchoscopy in Diagnosis and Management of Hemoptysis? during MD course. Research work done on immunotherapy in COPD, therapeutics in asthma, Intrapleural Streptokinase in Management of Multiloculated Thoracic Empyemas, bronchoscopy in Pulmonary Tuberculosis, Oral N-Acetylcysteine in COPD, Effectiveness of DOT strategy in treatment of tuberculosis, Antimycobacterial Drug Resistance in Pulmonary Tuberculosis, Severity Scoring Systems in Community Acquired Pneumonia, Low Pressure Suction for Non Resolving Pneumothorax/ Pyopneumothorax, Sclerosing Agents in Pleurodesis of Malignant Pleural Effusions, Non-invasive ventilation in COPD, High Resolution Computed Tomography Findings in asthma and COPD, Serum C reactive protein Levels and Other Clinically Important Predictive Markers of Outcome in COPD Patients, Endobronchial sclerotherapy for management of hemoptysis.
Number of years professional experience (list: years, position, name of employer)
Rotatory Internship Training. Including 9 months of Clinical Postings including one month of emergency posting and 6 weeks of rural health and training centre and 6 weeks of urban health training centre. J.N. Medical College, AMU Aligarh, India.(12 months) Resident, Department of TB & Chest Diseases. J.N. Medical College, AMU Aligarh, India. 26th Feb 2004-25th Feb 2007. (36 months) Senior Resident, Department of TB & Chest Diseases, Department of TB & Chest Diseases, J.N. Medical College, AMU Aligarh, India. 2nd March 2007-2nd May 2007. Registrar, Department of Chest Medicine, Government Medical College, Srinagar from August 2007 to June 2008. Lecturer, Department of Chest Medicine, Government Medical College, Srinagar from June 2008 till date.
Last two positions:
Position 1
Name of employer
From-To:
Registrar,
Government Medical College, Srinagar.
August 2007 to June 2008.
Position 2
Name of employer
From-To:
Lecturer.
Government Medical College, Srinagar.
June 2008 till date
Do you have 1 first author publication:
Yes - Role of Intrapleural Streptokinase in Management of Multiloculated Thoracic Empyemas. Naveed Nazir Shah, Arshad Altaf Bachh, Rakesh Bhargava, Zuber Ahmad, DK Panday, Mohd Shameem. J K Practitioner 2006;13(2):91-94 International Journal of Current Medical Science & Practice.-
Section 6 – ERS Fellowship application details Number of publications in international peer-reviewed periodicals as per date of this application
In English: 25
In other language: 0
Professional societies or associations of which you are a member:
Fellow, American College of Chest Physicians. ACCP ID: 300967 Fellow of Academy of General Education (FAGE) Manipal, India. Registration. No.11321 Member, European Respiratory Society. Membership No 158626. Member, American Association for Respiratory Care. Membership No. 9465666. Member, Asian Pacific Society of Respirology. Membership Number 1674 Member, Medical Council of India. Registration No. 5569. Member, J & K State Medical Council. Registration No. 468. Life Member, National College of Chest Physicians (India). Membership No LM- 0973. Life Member, Indian Chest Society. Membership No L-1136. Life Member, Indian Association of Bronchology. Membership No 295. Life Member, Indian Society for Study of Lung Cancer. Membership No179. Life Member, Indian College of Allergy, Asthma and Applied Immunology. LM-593
1
AZIENDA OSPEDALIERO-UNIVERSITARIA OSPEDALI RIUNITI UMBERTO I°- G.M. LANCISI – G. SALESI
ANCONA Dipartmento di Medicina Interna,
Malattie Immunoallergiche e Respiratorie S.O.D. DI PNEUMOLOGIA
(Direttore Dr. Stefano Gasparini
Ancona, August 2nd, 2010 ................................................................
Tel..: (071) 5964374 - 5964375 –5964338 Fax: (071) 5964344 Dr. NAVEED NAZIR SHAH POST BOX NO 1178, GENERAL POST OFFICE, SRINAGAR, J&K. INDIA. 190001 _________________________________________________ Dear Dr. Naveed Nazir Shah, I am pleased to invite you to attend the Thoracic Endoscopy Service of the Pulmonary Diseases Unit of the Azienda Ospedaliero-Universitaria “Ospedali Riuniti” of Ancona (Italy), for a period of three months training in 2011 (ERS short term fellowship), under my supervision. At the end of your training you will be able to know:
- the indication for bronchoscopy and medical thoracoscopy, - the instruments, accessories and how to organize a thoracic endoscopy room, - the management of the instrumentation (sterilization techniques), - how to manage the patients before, during and after the interventional procedures, - the role of bronchoscopy in the diagnosis of central and peripheral lesions, - the role of transbronchial needle aspiration in the diagnosis of hilar-mediastinal lesions, - the role of rigid bronchoscopy procedures (laser, electrocauthery, stents) in the management of
tracheobronchial obstruction, - the role of thoracoscopy in the diagnosis, staging and treatment of lung cancer, - the performing techniques for diagnostic and therapeutic purposes, - the management of chest tube drainage, - the possible complications of interventional procedures and their treatment.
During your fellowship you will not receive any income from the host supervisor. Yours sincerely, PROF. STEFANO GASPARINI, Director of Pulmonary Diseases Unit Azienda Ospedaliero-Universitaria "Ospedali Riuniti" of Ancona (Italy).
Department of Chest Medicine, Chest Disease Hospital, Srinagar
Fellowship in Interventional Pulmonology of Dr. Naveed Nazir Shah, Lecturer, Department of Chest Medicine, Chest Disease Hospital, Srinagar.
I wish to bring to your notice that Dr. Naveed Nazir Shah [M.D TB/RD} currently working as Lecturer in this department has been offered a research training fellowship in Interventional Pulmonology by Professor Stefano Gasparini, MD[Respiratory Medicine], University of Ancona, Director of Respiratory Diseases Unit, Azienda Ospedali Riuniti, Ancona, Italy in 2011. The fellowship is for three months to start next year in April 2011.
Pulmonology has become a vast field now and our department is starting full fledged interventional pulmonology facilities like rigid and video bronchoscopy with diagnostic and therapeutic procedures, video assisted thoracoscopy and polysomnography in our hospital. Presently we are not having any interventional pulmonologist in our institute. Interventional pulmonology is not part of the current program in pulmonology in India and there are no training institutes imparting training for the same. After completion of this fellowship, Dr Naveed Nazir Shah will be able to start a separate unit of interventional pulmonology in our institute.
I would like to mention that Dr Naveed is a promising doctor and extremely diligent. He is sincere, devoted and a keen learner. I strongly recommend him for the training programme during which he will research on project titled “TRADITIONAL TBNA vs EBUS GUIDED TBNA IN THE LUNG CANCER STAGING AND IN THE DIAGNOSIS OF MEDIASTINAL LESIONS: a prospective randomized study" for support by the ERS Fellowship Programme.
This fellowship program has no financial implication on the institution. He has been granted leave for the same period. However, he will not be paid any travelling allowance /dearness allowance/salary for the period of the training.
Dr M.M.Mirza
Head of the Department Department of Chest Diseases/Tuberculosis,
Chest Diseases Hospital, Srinagar
Curicullum Vitae Dr. Naveed Nazir Shah - Born in srinagar, J&K, India. (September 4, 1978) - Married, 1 daughter. Post Box No 1178, General Post Office, Srinagar. J&K.190001 Opposite Bhaba Atomic Research Centre, Zakoora, Srinagar, 190006. Jammu & Kashmir, India. +91-194-2422383, 2421101.Mobile: +91-9419016438. Email: [email protected]. Education:
S.S.C. (10th) 78.6 % Distinction JK Board. (1994) S.S.S.C. (12th) 84.6 % Distinction JK Board. (1997) Medical Degree (MBBS) at J.N. Medical College, AMU Aligarh, India with 65% marks with University Gold Medal In Pediatrics. (2003)
Registered in Medical Council of India. Registration No. 25133 (2003) Registered in J & K State Medical Council. Registration No. 7844. (2003) Specialized in Tuberculosis & Respiratory diseases at J.N. Medical College, AMU Aligarh, India. (2007)
Registered in Medical Council of India. Registration No. 5569. (2007) Registered in J & K State Medical Council. Registration No. 468. (2007)
Professional Career:
Consultant, Department of Chest Medicine, Government Medical College, Srinagar, J&K, India. 23rd June 2008 till date.
Academic Career:
Rotatory Internship Training. Including 9 months of Clinical Postings including one month of emergency posting and 6 weeks of rural health and training centre and 6 weeks of urban health training centre. J.N. Medical College, AMU Aligarh, India.(12 months)
Resident, Department of TB & Chest Diseases. J.N. Medical College, AMU Aligarh, India. 26th Feb 2004-25th Feb 2007. (36 months)
Senior Resident, Department of TB & Chest Diseases, Department of TB & Chest Diseases, J.N. Medical College, AMU Aligarh, India. 3rd April 2007-2nd May 2007. & 2nd March 2007- 1st April 2007.(2 months)
Registrar, Department of Chest Medicine, Government Medical College, Srinagar, J&K, India. 10th August 2007-23rd June 2008.
Lecturer/ Assistant professor, Department of Chest Medicine, Government Medical College, Srinagar, J&K, India. 23rd June 2008 till date.
MEMBERSHIP:
1. Fellow, American College of Chest Physicians. ACCP ID: 300967 2. Fellow of Academy of General Education (FAGE) Manipal, India. Fellow No. 11321. 3. Member, American Association for Respiratory Care. Membership No. 9465666. 4. Member, European Respiratory Society. Membership No 158626. 5. Member, Asian Pacific Society of Respirology. Membership Number 1674 6. Life Member, National College of Chest Physicians (India). Membership No LM-0973. 7. Life Member, Indian Chest Society. Membership No L-1136. 8. Life Member, Indian Association of Bronchology. Membership No 295. 9. Life Member, Indian Society for Study of Lung Cancer. Membership No179. 10. Life Member, Indian College of Allergy, Asthma and Applied Immunology. LM-593.
Research Achievements: Thesis work done on “Role of Bronchoscopy in Diagnosis and Management of
Hemoptysis”. Research work done on immunotherapy in COPD, therapeutics in asthma,
Intrapleural Streptokinase in Management of Multiloculated Thoracic Empyemas, bronchoscopy in Pulmonary Tuberculosis, Oral N-Acetylcysteine in COPD, Effectiveness of DOT strategy in treatment of tuberculosis, Antimycobacterial Drug Resistance in Pulmonary Tuberculosis, Severity Scoring Systems in Community Acquired Pneumonia, Low Pressure Suction for Non Resolving Pneumothorax/ Pyopneumothorax, Sclerosing Agents in Pleurodesis of Malignant Pleural Effusions, Non-invasive ventilation in COPD, High Resolution Computed Tomography Findings in asthma and COPD, Serum C reactive protein Levels and Other Clinically Important Predictive Markers of Outcome in COPD Patients, Endobronchial sclerotherapy for management of hemoptysis.
PARTICIPATION
• National and International Scientific Meetings, Conferences and CME’s Attended:30 • National and International Workshops Attended: 14
Papers presented at conferences: 25 including oral presentations in
• International Respiratory Congress 2007 at Las Vegas, USA, • European Respiratory Society 2008 and • Chest, American College of Chest Physicians 2009 & a • Guest lecture on World Tuberculosis Day 2006.
ORGANIZATIVE ACTIVITY
- Joint organising secretary of the conference of State task force for RNTCP. 2010 PUBLICATIONS - Author of 35 pubblications.
Additional Achievements:
1. Got Geeta Bajaj and University Gold Medals for getting highest marks in Pediatrics in MBBS.
2. Was member of the Pulse Polio Eradication team. 3. Was the HOUSE CAPTAIN of Tyndale Biscoe School. 4. Was declared the BEST ALL ROUND BOY at Tyndale Biscoe School in 1994. 5. Got the award for being the BEST IN ACADEMICS in Tyndale Biscoe School. 6. Have qualified the All India UN information test conducted by the Council for
UN information, United Schools Organisation of India, VEC for the United Nations securing 89% marks.
7. Have qualified the All India General Knowledge Tests conducted by the All India Board of General Knowledge test, United Schools Organisation of India, VEC for the United Nations securing 81% marks at pre-senior level and 88% marks at senior level.
8. Have qualified the All India UNESCO Information Test conducted United Schools International, United Nations securing 74% marks.
9. Got prizes in essay competitions, debates and quizzes at school and college level. 10. Am an active in sports and a have been member of cricket, football, and
basketball, volleyball and hockey teams in school and college and have won prizes at different levels.
Dr. Naveed Nazir Shah. LIST OF PUBLICATIONS in the Order
1. Effect of Bronchovaxom on Incidence and Severity of Upper Respiratory Tract
Infections in COPD Patients. Mohd Shameem, Rakesh Bhargav, Zuber Ahmed, Devendra Sharma, Naveed Nazir Shah. Indian Journal of Allergy, Asthma and Immunology 2005;19(1):37-42.
Official Publication of the Indian College of Allergy, Asthma and Applied Immunology.
2. Monotherapy with Long Acting β2 Agonists as an Alternative Therapy to Inhaled Corticosteroids in Stable Persistent Asthma.
Arshad Altaf Bachh, Naveed Nazir Shah, Rakesh Bhargava, Zuber Ahmad, DK Panday, Mohd Shameem. Indian Journal of Allergy, Asthma and Immunology 2005;19(2): 81-84. Official Publication of the Indian College of Allergy, Asthma and Applied Immunology. 3. Multiple Bilateral Rib Fractures Associated with Severe Coughing. Mohd Shameem, R Bhargava, Z Ahmed, Naveed.
J K Practitioner 2005;12(4):199-200. International Journal of Current Medical Science & Practice.
4. Role of Intrapleural Streptokinase in Management of Multiloculated Thoracic Empyemas. Naveed Nazir Shah, Arshad Altaf Bachh, Rakesh Bhargava, Zuber Ahmad, DK Panday, Mohd Shameem. J K Practitioner 2006;13(2):91-94 International Journal of Current Medical Science & Practice. 5. Mediastinal Hydatid Cyst rupturing into the Pleural Cavity Associated with
Pneumothorax: Case Report and Review of the Literature. M Shameem, Rakesh Bhargava, Zuber Ahmad, Nazish Fatima, Naveed Nazir Shah. Canadian Respiratory Journal 2006;13(4):211-213. Official Journal of the Canadian Thoracic Society.
6. Comparison of Bronchoalveolar Lavage Fluid with Sputum Culture in Diagnosis of Sputum Smear Negative Pulmonary Tuberculosis.
Naveed Nazir Shah, Arshad Altaf Bachh, Rakesh Bhargava, Mohammad Muzaffar Mirza, Zuber Ahmed, D.K. Pandey, Mohd Shameem, Khurshid A Dar, Inaamul Haq.
Journal of Medical Sciences.2006;9(2):136-139. Official publication of Sheri-I-Kashmir Institute of Medical Sciences.
7. Pulmonary Artery Aneurysm Mimicking a Lung Mass. Mohd Shameem, Rakesh Bhargava, Zuber Ahmad, Naveed Nazir Shah, Nazish Fatima, Ashish Bhargava. Lung India 2007;24(1):22-24. Official Publication of the Indian Chest Society.
8. Unilateral Bullous Emphysema of Lung. Naveed Nazir Shah, Rakesh Bhargava, Zuber Ahmed, D.K. Pandey, Mohd Shameem, Arshad Altaf Bachh, Md. Shamim Akhtar, Khurshid A Dar, Mir Mohsin.
Lung India 2007; 24(1):30-32. Official Publication of the Indian Chest Society.
9. Effect of Oral N-Acetylcysteine in COPD-A Randomised Controlled Trial. Arshad Altaf Bachh, Naveed Nazir Shah, Rakesh Bhargava, Zuber Ahmed, D.K. Pandey, Khurshid A Dar, Inaamul Haq. J K Practitioner 2007;14(1):12-16. International Journal of Current Medical Science & Practice. 10. Epidural Extension of Tuberculosis Pleural Empyema Causing Cord Compression. Mohd Shameem, Rakesh Bhargava, Zuber Ahmed, Naveed Nazir Shah, Faisal Haque, Zafar Abas, Syed Ameer.
Indian Journal of Chest diseases and Allied Sciences 2007;49(2):107-110. Publication of Vallabhbhai Chest Institute, University of Delhi, & National College of Chest Physicians (India). 11. Bilateral Pneumothorax, Pneumomediastinum and Subcutaneous Emphysema – Rare Complications of Percutaneous Tracheostomy. Naveed Nazir Shah, Rakesh Bhargava, Zuber Ahmed, Mohd Shameem, Mohammad Muzaffar Mirza, Arshad Altaf Bachh, Khurshid Ahmad Dar, Nisar H Dar, Mir Mohsin. J K Practitioner. 2007;14(3):91-94. International Journal of Current Medical Science & Practice.
12. The Vanishing Lung Naveed Nazir Shah, Arshad Altaf Bachh, Rakesh Bhargava, Zuber Ahmed, D.K. Pandey, Mohd Shameem, Khurshid Ahmad Dar. Canadian Journal of Emergency Medicine 2007;9(3):170,233-34. Official Journal of the Canadian Association of Emergency Physicians/ Association. 13. Endobronchial aspergilloma in a 30-year-old male. Khurshid Ahmad Dar, Naveed Nazir Shah, Rakesh Bhargava, Zuber Ahmed, Deepak Kumar Pandey, Nisar Hussain Dar, Arshad Altaf Buchh, Md S Akhtar, Faiz Ahmed. Journal of Bronchology 2007 14(3):207-209. Official Journal of American Association for Bronchology and World Association for Bronchology.
14. Nasogastric tube knotting with tracheoesophageal fistula – a rare association. Mir Mohsin, Iqbal Saleem Mir, Mohammed Hanief Beg, Naveed Nazir Shah, Suraiya Arjumand Farooq, Arshad Altaf Bachh, Abdul Quadir. Interactive CardioVascular and Thoracic Surgery 2007; 6:508-510. Official Publication of European Association for Cardio-Thoracic Surgeons. 15. To study the effectiveness of DOTS at J.N. Medical College, Aligarh. Shamim Akhtar, Rakesh Bhargava, Zuber Ahmad, D K. Pandey, Naveed Nazir Shah, Khurshid Ahmad Dar. Lung India 2007; 24(4):128-131.
Official Publication of the Indian Chest Society.
16. Hydatid Disease of the Breast: A Case Report. Mir Mohsin, Iqbal S Mir, Naveed N Shah, Saifuddin B Fakir, Abdul Quadir. JIMA 2008; Volume 40 February, 35-37. Journal of the Islamic Medical Association of North America.
17. Eventration of diaphragm with gastric volvulus: a case report Naveed N Shah, Mir Mohsin, Syed Q Khursheed, Syed SA Farooq, Arshad A Buchh, Abdul Q Quraishi. Cases Journal 2008, 1:404.
18. Study of Antimycobacterial Drug Resistance in Pulmonary Tuberculosis in Kashmir. Javid A. Malik, Naveed N.Shah, Mir Sadaqat, Tanuja A Makhdoomi, Shuba N. Molvi.
Indian Journal for the Practising Doctor. 2008; 4: 4. 19. Mature mediastinal teratoma in adult.
Mohammad Shameem , Syed M. Danish Qaseem, M Azfar Siddiqui, Naveed Nazir Shah, Asrar Ahmad. Respiratory Medicine CME 2009; 1–2.
20. Validity of Pneumonia Severity Index and CURB-65 Severity Scoring Systems in Community Acquired Pneumonia in an Indian Setting
Bashir Ahmed Shah, Wasim Ahmed, Ghulam Nabi Dhobi, Naveed Nazir Shah, Syed Quibtiya Khursheed, Inaamul Haq. Indian Journal of Chest diseases and Allied Sciences 2010; 52(1):9-17. Publication of Vallabhbhai Chest Institute, University of Delhi, & National College of Chest Physicians (India).
21. To study the effectiveness of DOTS at Chest Disease Hospital, Srinagar. Mohammad Muzaffar Mirza, Naveed Nazir Shah, Mushtaq Ahmad Wani.
Kashmir Medical Journal 2010; 24(2):128-131.
22. Low Pressure Suction for Non Resolving Pneumothorax/ Pyopneumothorax. Mohd Shameem, R. Bhargava, Z. Ahmad, D.K. Sharma, Naveed. Indian Journal of Tuberculosis 2005;52(3):159-60.
Official Publication of the Tuberculosis Association of India.
23. Oral Immunostimulating Therapy in COPD. Mohd Shameem, Rakesh Bhargav, Zuber Ahmad, Devandra Sharma, Naveed Nazir. Respirology 2005;10 Suppl:A100. Official Journal of Asian Pacific Society of Respirology.
24. Comparison of Bronchoalveolar Lavage Fluid with Sputum Culture in
the Diagnosis of Sputum Smear Negative Pulmonary Tuberculosis. Naveed Nazir Shah, Arshad Altaf Bachh, Rakesh Bhargava, Zuber Ahmed, D.K. Pandey, Mohd Shameem. Indian Journal of Tuberculosis 2006;53(3):163-164. Official Publication of the Tuberculosis Association of India.
25. A Comparative Study of Use of Bleomycin and Talc as Sclerosing Agent in Pleurodesis of Malignant Pleural Effusions. Naveed Nazir Shah, Arshad Altaf Bachh, Rakesh Bhargava, Zuber Ahmed, DK Pandey, Mohd Shameem. Indian Journal of Tuberculosis 2006;53(3):166-167. Official Publication of the Tuberculosis Association of India.
25. Comparative study between Bi-level positive pressure (BiPAP) ventilation combined with oxygen therapy and oxygen mono therapy in acute exacerbation of COPD. Mohd Shameem, Rakesh Bhargava, Zuber Ahmad, Naveed Nazir Shah.
Respiratory Care 2006;51(11):1277. Official Journal of American Association of Respiratory Care. 26. Immunostimulant therapy in preventing respiratory infections in COPD Patients. Mohd Shameem, Rakesh Bhargava, Zuber Ahmad, Naveed Nazir Shah.
Respiratory Care 2006;51(11):1277. Official Journal of American Association of Respiratory Care. 27. Correlation of High Resolution Computed Tomography Findings with Disease Severity in Asthma.
Naveed Nazir Shah, Khurshid A Dar, Rakesh Bhargava, Zuber Ahmed, Ibne Ahmad, D.K Pandey, Md. Shameem, Arshad Altaf Bachh, Md Shamim Akhtar, Inam ul Haque.
Respiratory Care 2006;51(11):1277. Official Journal of American Association of Respiratory Care.
28. Correlation of high resolution computed tomography (HRCT) findings with disease severity in chronic obstructive pulmonary disease (COPD). Rakesh Bhargava, Khurshid A Dar, Zuber Ahmed, Ibne Ahmad, Naveed Nazir Shah, DK Pandey, Mohd Shamim Akhtar, Arshad Altaf Bachh, Imran Ahmad Khan, Inaamul Haq
European Respiratory Journal 2007 478s Official Publication of the European Respiratory Society. 29. To Co-Relate Serum C - reactive protein Levels and Other Clinically Important Predictive Markers of Outcome in COPD Patients Mohammad Shameem, Rakesh Bhargava, Zuber Ahmad, Talha Saad, Nazish Fatima, Naveed Shah. Chest 2007; 132(4): 532b. Official Publication of the American College of Chest Physicians.
30. Endobronchial Aspergilloma – Presenting as Solitary Pulmonary Nodule. Nazish Fatima, Mohammad Shameem, Rakesh Bhargava, Zuber Ahmad, Talha Saad, Naveed Nazir.
Respirology 2007;12 Suppl 4: A231. Official Journal of Asian Pacific Society of Respirology.
31. Endobronchial sclerotherapy for management of hemoptysis. Naveed Nazir Shah, Rakesh Bhargava, Zuber Ahmad , Quibtiya Syed, Khurshid Dar, Mohammad Shameem, Mohammad Muzaffar Mirza.
European Respiratory Journal 2008. 251s Official Publication of the European Respiratory Society. 32. Oral immunotherapy in preventing exacerbations of COPD. Naveed Nazir Shah, Rakesh Bhargava, Zuber Ahmed, Mohammad Shameem, Khurshid Ahmad Dar, Quibtiya Syed, Mohammad Muzaffar Mirza, Arshad Altaf Bachh. European Respiratory Journal 2008. 630s Official Publication of the European Respiratory Society.
33. Assessment of airway remodeling in asthma by indirect methods.
Rakesh Bhargava, Khurshid A Dar, Zuber Ahmad, Deepak K Pandey, Najm ul Islam, Rana Sherwani, Ibne Ahmed, Inam-Ul Haq, Naveed N. Shah, Arshad A Bachh, Mudasir Mushtaq.
European Respiratory Journal 2008. 748s Official Publication of the European Respiratory Society.
34. Can long-acting β2 agonists substitute inhaled corticosteroids In stable Persistent Asthma. Quibtiya K Syed, Naveed N Shah, Arshad A. Bachh, Rakesh Bhargava, Zuber Ahmed, Deepak K Pandey, Mohammad Shameem, Khurshid A Dar. Chest 2008; 134(4).
Official Publication of the American College of Chest Physicians. 35. Validity of Pneumonia Severity Index and CURB-65 Severity Scoring Systems in Community-Acquired Pneumonia in a Third World Country.
Naveed Nazir Shah, Syed Quibtiya Khursheed, Bashir Ahmed Shah, Wasim Ahmed, Ghulam Nabi Dhobi, Inaamul Haq.
Chest 2009. Official Publication of the American College of Chest Physicians.
Papers Accepted for Publication:
Unilateral Pulmonary Edema Resulting From Drainage of Spontaneous Pneumothorax. Naveed Nazir Shah, Rakesh Bhargava, Zuber Ahmed, DK Pandey, Mohammad Muzaffar Mirza, Mohd Shameem, Arshad Altaf Bachh, Khurshid A Dar.
In J K Practitioner. International Journal of Current Medical Science & Practice. Papers under Communication:
A Comparative Study of Use of Bleomycin and Talc as Sclerosing Agent in Pleurodesis of Malignant Pleural Effusions. Naveed Nazir Shah, Arshad Altaf Bachh, Rakesh Bhargava, Zuber Ahmed, DK Pandey, Mohd Shameem, Khurshid A Dar, Inaamul Haq.
In Turkish Respiratory Journal. Official Publication of Turkish Thoracic Society.
Project Description The aim of the project is to get training in the new techniques in interventional
pulmonology like Endobronchial Ultrasound, transbronchial needle aspiration/biopsy electromagnetic navigation, autoflouresence bronchoscopy, rigid bronchoscopy procedures (laser, electrocautery, stents) and thoracoscopy. During the training period I will work on research project titled “TRADITIONAL TBNA vs EBUS GUIDED TBNA IN THE LUNG CANCER STAGING AND IN THE DIAGNOSIS OF MEDIASTINAL LESIONS: a prospective randomized study".
Introduction: 1) TBNA is a safe technique for hilar-mediastinal lymph node staging and for the diagnosis of mediastinal lesions. 2) Traditional TBNA has a sensitivity of about 78% that is lower in comparison to diagnostic yield of EBUS-TBNA. 3) However, traditional TBNA has several advantages: it can be performed during the first diagnostic bronchoscopy; it can be performed in every bronchoscopic service; it is cheaper in comparison to EBUS TBNA 4) there are no randomized studies that really assess the differences in diagnostic yield and in costs of both techniques
Objective of the study: To compare the results obtained by traditional TBNA and by EBUS-TBNA and to verify in which cases (lymph node location, lymph node size, kind of pathology) the use of EBUS is really advantageous.
Methods: The study is a prospective randomized study. All patients with a mediastinal lymph node enlargement or lesion that require a cyto-histological assessment will be included in the study. Patients will be randomized in two groups: 1) EBUS-TBNA; 2) Traditional TBNA. The samples obtained by traditional TBNA will be evaluated by rapid on-site cytological evaluation. If specimens will be not diagnostic, EBUS will be performed. For each patient, the following parameters will be recorded: size and location of the lymph nodes; time of the procedure; EBUS-TBNA or traditional TBNA diagnosis; final diagnosis.
Results: The results obtained in two arms will be compared. The cost-effectiveness of both strategies will be evaluated (EBUS-TBNA as first step or EBUS-TBNA just in case of traditional TBNA not diagnostic).
I have done my MD in Pulmonary Medicine. I have basic knowledge of interventional pulmonology and I am already experienced in the basic procedures of pulmonology like thoracentesis, chest tube placement, intubation with laryngoscopy and flexible bronchoscopy during my post graduation. However, Interventional pulmonology is not part of the current program of pulmonology in my country, India. The interventional procedures are performed in only a small proportion of respiratory centres in India. There are no centres in India which impart training in interventional pulmonology. I am presently working as Lecturer in the Department of Chest Medicine, Government Medical College, Srinagar, J&K, India, which is a tertiary care centre. Our hospital has been upgraded to the level of an institute with the facilities of video bronchoscope with accessories, video-thoracoscope, rigid bronchoscope with the accessories and polysomnography. So we are having all the facilities of starting interventional pulmonology in our department and we plan to start a separate unit of interventional pulmonology in near future and the present training stint will help me in a huge way to accomplish the task and carry out research in the field. Since I am already well versed in the basic procedures, a training stint of three months will be sufficient for me to complete the project.
I have been invited by Dr. Stefano Gasparini, the Head of the Respiratory Diseases Unit of the Department of Internal Medicine, Immunoallergic and Respiratory Diseases, Azienda Ospedaliero-Universitaria "Ospedali Riuniti" Via Conca, Ancona, Italy, to attend the Thoracic Endoscopy Service for training in interventional pulmonology for a period of three months from April to June 2011. The institute has a recognized prestige and is a pioneering centre of interventional pulmonology. Dr. Stefano Gasparini, who is also the Secretary of the Study Group “Interventional Pulmonology” of the European Respiratory Society (ERS) is a known figure in bronchology and has agreed for research on the given topic.
After completion of the training and research project, I can carry on the research and the procedures and as we have the facilities for the same in my home institute.
Introduction: The assessment of mediastinal lymph nodes and masses is important for both
diagnostic purposes and (lung) cancer staging. Imaging methods, such as computed tomography (CT) and positron emission tomography (PET), indicate size and metabolic activity, respectively, of mediastinal nodes with a sensitivity and specificity of 57–82% (CT) and 84–89% (PET), respectively [1]. Surgical staging by mediastinoscopy has a high sensitivity (81%) and specificity (100%) [2]. However, it is an invasive procedure that requires general anaesthesia and clinical admission. Endoscopic techniques provide a minimally invasive alternative for surgical staging. The addition of transbronchial needle aspiration (TBNA) to fibrebronchoscopy bronchoscopy has not only improved bronchoscopy’s diagnostic yield, it further extended the role of bronchoscopy in the evaluation of mediastinal pathology, and in the diagnosis and staging of bronchogenic carcinoma [3,4].
The first description of sampling mediastinal lymph nodes through the tracheal carina using a rigid bronchoscope was by SCHIEPPATI [5], an Argentinian physician. In 1978, WANG et al. [6] demonstrated that it was feasible to sample paratracheal nodes using TBNA. In 1979, OHO et al. [7] introduced a flexible needle that could be utilised through a flexible fibrebronchoscope and in 1983, WANG and co-workers [8] reported the use of TBNA for lung cancer staging and developed new types of needles.
The integration of ultrasound technology and flexible fibrebronchoscopy enables imaging of lymph nodes, lesions and vessels located beyond the tracheobronchial mucosa. The available EBUS application are the radial endobronchial ultrasound (EBUS) probe (mini-probe) where an ultrasound transducer with a frequency of 20 MHz is used and a linear or longitudinal EBUS scope channel where a 7.5 MHz curved linear array ultrasound scanner is used. A large randomised trial, between conventional TBNA and TBNA after EBUS localisation, for mediastinal staging of enlarged nodes demonstrated that EBUS guidance significantly increased the yield of TBNA in all stations (84 versus 58%)[9].
The aim of our study is to compare the results obtained by traditional TBNA and by EBUS-TBNA and to verify in which cases (lymph node location, lymph node size, kind of pathology) the use of EBUS is really advantageous.
Materials & Methods This will be a prospective randomized study and will be carried out in Respiratory
Diseases Unit of the Department of Internal Medicine, Immunoallergic and Respiratory Diseases, Azienda Ospedaliero-Universitaria "Ospedali Riuniti" Via Conca, Ancona, Italy. All patients with a mediastinal lymph node enlargement or lesion that require a cyto-histological assessment will be included in the study. Patients will be randomized in two are: 1) EBUS-TBNA; 2) Traditional TBNA. The samples obtained by traditional TBNA will be evaluated by rapid on-site cytological evaluation. If specimens will be not diagnostic, EBUS will be performed. For each patient, the following parameters will be recorded: size and location of the lymph nodes; time of the procedure; EBUS-TBNA or traditional TBNA diagnosis; and the final diagnosis.
Material: All needle systems for transbronchial aspiration consist of: a retractable, sharp, bevelled, flexible needle; a flexible catheter; a proximal control device to manipulate the needle, the stylet, or both; and a proximal port through which suction can be applied. To obtain cytology specimens, 20–22-gauge needles are usually used, while 19-gauge needles are needed to obtain a ‘‘core’’ of tissue for histology [10].
Procedure: The CT of the patient will be reviewed for proper selection of the proper site for needle insertion to increase diagnostic yield. TBNA can be performed safely and successfully for unexpected endobronchial lesions encountered during routine flexible bronchoscopy. The fiberbronchoscope is kept straight as possible, with its distal tip in the neutral position during catheter insertion. The bevelled end of the needle is secured within the metal hub and is advanced and locked in place only after the metal hub is visible beyond the tip of the working channel. The catheter is retracted, keeping the tip of the needle distal to the end of the fibrebronchoscope. The scope is then advanced to the target area and the tip of the needle is anchored in the intercartilaginous space in an attempt to penetrate the airway wall as
perpendicularly as possible. The following techniques will be used to insert the needle through the airway wall. 1) The ‘‘jabbing method’’, whereby the needle is thrust through the intercartilaginous space with a quick, firm jab to the catheter. 2) The ‘‘hub against the wall method’’, whereby the distal end of the catheter (the metal hub) is be placed directly in contact with the target, with the needle in the retracted position, and held firmly while the needle is pushed out of the catheter for its spontaneous penetration through the tracheobronchial wall. 3) The ‘‘piggyback method’’, whereby, once the needle is advanced and locked in position, the catheter is fixed against the proximal end of the insertion port, to prevent recoil when resistance is met; the bronchoscope and catheter are then pushed forward as a single unit, until the entire needle penetrates the tracheobronchial wall. 4) The ‘‘cough method’’, where the patient is asked to give a hard cough to encourage the spontaneous penetration of the needle while applying the jabbing or piggyback technique. All of these techniques can be used alone or in combination.
With the needle inserted, suction is applied at the proximal port using a syringe. When there is no blood in the aspirate, the catheter is moved up and down with continuous suction. The needle is withdrawn from the target site after suction is released. The tip of the scope is straightened and the needle assembly is pulled out of the scope in a single, smooth motion. The specimen for cytology is prepared by using air from a 60-mL syringe to ‘‘blow’’ the specimen out to the slide before smearing it using another slide.
The technique of obtaining a histology specimen via TBNA requires use of the 19-gauge needle assembly and is a variation on the technique used to obtain cytology specimens. Once the metal hub is visible beyond the tip of the fibrebronchoscope, the 19-gauge needle is advanced beyond the metal hub and locked in place. The automatically advanced 21-gauge needle is used to puncture the airway wall and anchored at the target site using any of the techniques previously described. The 21- gauge needle acts as a trocar for the 19-gauge needle and prevents its plugging by bronchial wall tissue. Using a syringe, suction is applied at the proximal port to ascertain the safety of the location. This is followed by the insertion of the 19-gauge needle to its fullest extent. Under continuous suction, the 19-gauge needle is moved up and down, 4–5 times, to obtain a core of tissue.
At least two satisfactory core specimens are obtained at each location and multiple passes may be required to increase the diagnostic yield. Rapid on-site evaluation of the specimen by the cytopathologist for sample adequacy has been shown to increase diagnostic yield.
EBUS-TBNA: A linear or longitudinal EBUS scope (BF-UC160F-OL8; Olympus Medical Systems, Tokyo, Japan) with an outward diameter of 6.9 mm, a 35-degree forward oblique optic, a 2.0 mm working channel and a 7.5 MHz curved linear array ultrasound scanner. EBUS-TBNA can be performed in an ambulatory setting under conscious sedation using midazolam. The probe is conventionally inserted through the working channel of a flexible bronchoscope and positioned near the target area. EBUS images detail the airway wall as well as parabronchial structures. The actual TBNA is performed by direct transducer contact with the wall of the trachea or bronchus. When a lesion is outlined, a 22-gauge full-length steel needle is introduced through the biopsy channel of the endoscope. Under real-time ultrasonic guidance, the needle is placed in the lesion. Suction is applied with a syringe, and the needle is moved back and forth inside the lesion.
Discussion The diagnostic yield of TBNA in the assessment of hilar–mediastinal lymph nodes
involvement in lung cancer varies greatly in the published literature, from 15%, reported by SHURE and FEDULLO [11], to 85%, obtained by SCHENK et al. [12]. Recently, a meta-analysis regarding TBNA for the mediastinal staging for nonsmall cell lung cancer demonstrated that TBNA is highly specific for the identification of mediastinal metastases, whereas the sensitivity depends heavily on the study population under investigation [13]. In studies that included patients with a prevalence of mediastinal metastases of 34%, sensitivity was only 39%, whereas in a population with a prevalence of 81% it was 78%. A higher sensitivity is obtained in patients with established lymph node enlargement on CT. SHURE
and FEDULLO [11] found that the sensitivity increased from 15 to 38% if only subjects with evidence of lymphadenopathy at CT were considered.
The kind of needle employed can influence the results and that the use of histology needles, introduced by WANG et al. [8], can further improve the sensitivity of the technique.SCHENK et al. [10] found the sensitivity of the 19-gauge needle (85.5%) was statistically higher than that of the 22-gauge needle (52.7%). The sensitivity of the combined cytology and histology samples was higher (89.1%) than either individual sampling.
PATELLI et al. [4] and HARROW et al. [14], found that the overall sensitivity of the technique in assessing lymph node metastases significantly less sensitive in left than those performed in the right paratracheal or in the subcarinal stations. HARROW et al. [14] also underline the fact that increase in lymph node size increased results of TBNA.
CHIN et al. [15] reported a tumour-positive aspiration rose incrementally with successive aspirates upto at the seventh sample. The presence of rapid on-site cytopathologic examination (ROSE) was associated with a significantly higher yield (71%) of than the value obtained if ROSE was absent (25%). DAVENPORT [16], too found a significant increase in the percentage of specimens containing malignant cells in 31% using ROSE in comparison with routinely processed TBNAs (56 versus 31%). HAPONIK and STURE [17] demonstrated that the diagnostic yield on TBNA increased from 21.4 to 47.6% during a 3-yr period of training and of educational intervention. The role of experience in performing TBNA is also supported by the analysis of the results of more recent studies, which consistently report sensitivities of TBNA 70% [4,14].
No cases of mortality related to TBNA have been described. The rare complications reported are pneumothorax, pneumomediastinum, haemomediastinum, bacteraemia and pericarditis. None of these complications determined major clinical consequences.
Several studies have been conducted using EBUS for the localisation of mediastinal nodes. In a prospective study of 242 patients with enlarged mediastinal nodes (mean diameter 1.7 cm) at chest CT, all target nodes could be identified by EBUS, independently of size or location. Adequate samples were obtained in 86% of cases and malignant lymph node involvement was assessed in 72% of cases [18]. A large (n5200) randomised trial, between conventional TBNA and TBNA after EBUS localisation, for mediastinal staging of enlarged nodes demonstrated that EBUS guidance significantly increased the yield of TBNA in all stations (84 versus 58%), except in the subcarinal region (86 versus 74%) [9].
Mediastinal and hilar nodal staging is the main indication for EBUS-TBNA. Additionally, intrapulmonary tumours located adjacent to the main bronchi can be aspirated. Biopsies obtained on 11 patients in 15 intrapulmonary lesions through EBUS-TBNA showed malignant cells in 13 lesions and benign cells in two.[19] YASUFUKU et al. [20] found in 70 patients with suspected lung cancer and enlarged mediastinal or hilar nodes with EBUS-TBNA the sensitivity, specificity and accuracy of EBUS-TBNA in distinguishing benign from malignant lymph nodes were 96, 100 and 97%, respectively. In a subsequent study from the same group, in 108 patients with (suspected) lung cancer and enlarged mediastinal nodes on CT, EBUS-TBNA had a sensitivity of 95%, specificity of 100% and accuracy of 96% in assessing mediastinal nodes [21]. In the largest study to date, by HERTH et al. [22], real-time EBUS-TBNA was performed in patients with (suspected) lung cancer and enlarged mediastinal nodes on chest CT resulted in a diagnosis in 94% patients and a sensitivity of 94% and a specificity of 100% for mediastinal staging was reported. In contrast to all prior studies, which were performed in selected patients with enlarged mediastinal nodes on chest CT, EBUS-TBNA was evaluated in a prospective study in 100 patients with non-small cell lung cancer without enlarged nodes at chest CT. Surgical verification was performed in all patients. In assessing mediastinal nodal status, EBUS-TBNA had a sensitivity of 92% a specificity of 100% and a negative predictive value of 96% [23].
To date, no complications have been reported in EBUS-TBNA studies. Results so far indicate that real-time EBUS-TBNA is a safe and accurate method for the mediastinal staging in patients with (suspected) lung cancer.
Training in TBNA is urgently advocated as it will optimise the care of patients with lung cancer [54].
REFERENCES
1. Toloza EM, Harpole L, McCrory DC. Noninvasive staging of non-small cell lung cancer: a review of the current evidence. Chest 2003;123: Suppl. 1, 137S–146S.
2. Sihoe AD, Yim AP. Lung cancer staging. J Surg Res 2004; 117: 92–106. 3. Gasparini S. Bronchoscopic biopsy techniques in the diagnosis and staging of lung cancer.
Monaldi Arch Chest Dis 1997; 52: 392–398. 4. Patelli M, Agli LL, Poletti V, et al. Role of fiberscopic transbronchial needle aspiration in the
staging of N2 disease due to non-small cell lung cancer. Ann Thorac Surg 2002; 73: 407–411.
5. Schieppati E. La puncion mediastinal a traves del espolon traqueal. [Trans-tracheal aspiration of the mediastinum]. Rev As Med Argent 1949; 663: 497–499.
6. Wang KP, Terry PB, Marsh B. Bronchoscopic needle aspiration biopsy of paratracheal tumors. Am Rev Respir Dis 1978; 118: 17–21.
7. Oho K, Kato H, Ogawa I, Hayashi N, Hayata Y. A new needle for transfiberoptic bronchoscope use. Chest 1979; 76: 492.
8. Wang KP, Marsh BR, Summer WR, Terry PB, Erozan YS,Baker RR. Transbronchial needle aspiration for diagnosis of lung cancer. Chest 1981; 80: 48–50.
9. Herth F, Becker HD, Ernst A. Conventional vs endobronchial ultrasound-guided transbronchial needle aspiration: a randomized trial. Chest 2004; 125: 322–325.
10. Schenk DA, Chambers SL, Derdak S, et al. Comparison of the Wang 19 gauge and 22 gauge needles in the mediastinal staging of lung cancer. Am Rev Respir Dis 1993; 147: 1251–1258.
11. Shure D, Fedullo PF. The role of transcarinal needle aspiration in the staging of bronchogenic carcinoma. Chest 1984; 86: 693–696.
12. Schenk DA, Bower JH, Bryan CL, et al. Transbronchial needle aspiration staging of bronchogenic carcinoma. Am Rev Respir Dis 1986; 134: 146–148.
13. Holty JE, Kuschner WG, Gould MK. Accuracy of transbronchial needle aspiration for mediastinal staging of nonsmall cell lung cancer: a meta-analysis. Thorax 2005; 60:949–955.
14. Harrow EM, Abi-Saleh W, Blum J, et al. The utility of transbronchial needle aspiration in the staging of bronchogenic carcinoma. Am J Respir Crit Care Med 2000; 161: 601–607.
15. Chin R Jr, McCain TW, Lucia MA, et al. Transbronchial needle aspiration in diagnosing and staging lung cancer.How many aspirates are needed?Am J Respir Crit Care Med 2002; 166: 377–381.
16. Davenport RD. Rapid on-site evaluation of transbronchial aspirates. Chest 1990; 98: 59–61. 17. Haponik EF, Sture D. Underutilization of transbronchial needle aspiration: experience of
current pulmonary fellows. Chest 1997; 112: 251–253. 18. Herth FJ, Becker HD, Ernst A. Ultrasound-guided transbronchial needle aspiration: an
experience in 242 patients.Chest 2003; 123: 604–607. 19. Krasnik M, Vilmann P, Larsen SS, Jacobsen GK. Preliminary experience with a new method
of endoscopic transbronchial real time ultrasound guided biopsy for diagnosis of mediastinal and hilar lesions. Thorax 2003; 58: 1083–1086.
20. Yasufuku K, Chiyo M, Sekine Y, et al. Real-time endobronchial ultrasound-guided transbronchial needle aspiration of mediastinal and hilar lymph nodes.Chest 2004; 126:122–8.
21. Yasufuku K, Chiyo M, Koh E, et al. Endobronchial ultrasound guided transbronchial needle aspiration for staging of lung cancer. Lung Cancer 2005; 50: 347–354.
22. Herth FJ, Eberhardt R, Vilmann P, Krasnik M, Ernst A. Real-time, endobronchial ultrasound-guided, transbronchial needle aspiration: a new method for sampling mediastinal lymph nodes. Thorax 2006; 61: 795–798.
23. Herth FJ, Ernst A, Eberhardt R, Vilmann P, Dienemann H, Krasnik M. Endobronchial ultrasound-guided transbronchial needle aspiration of lymph nodes in the radiologically normal mediastinum. Eur Respir J 2006; 28: 910–914.
24. Gasparini S, Silvestri GA. Usefulness of transbronchial needle aspiration in evaluating patients with lung cancer. Thorax 2005; 60: 890–891.
1
CURRICULUM VITAE - Dr. Mohammad Muzaffar Mirza - Born in Srinagar, J&K (India) (June 1st 1956) - Married, 1 son, 2 daughters EDUCATION - Medical Degree at the Govt Medical College, Kashmir University(November 3, 1978) - Registered at the Jammu & Kashmir Medical Council (December, 1978) - Specialized in Internal Medicine, Govt Medical College, Kashmir University.(1988) PROFESSIONAL CAREER - Medical Officer, JK Health Services 1982-1985, JK, India. - Consultant, Department of Chest Medicine, Government Medical College, Srinagar from 1990 to 2006. - Chief Consultant and Head of Department of Chest Medicine, Government Medical College, Srinagar from 2006 ACADEMIC CAREER - Registrar of Chest Medicine at the Government Medical College, Srinagar from
1988 to 1990. - Lecturer of Chest Medicine at the Government Medical College, Srinagar from
1990 to 2006. - Assistant Professor of Chest Medicine at the Government Medical College, Srinagar
from 2001 to 2006. - Associate Professor and Head of Department of Chest Medicine at the Government
Medical College, Srinagar from 2006 MEMBERSHIP - Member, Indian Chest Society. - Member of National College of Chest physicians. - Member, Kashmir lung society. HONORS - Nodal Officer, State Task Force in RNTCP of JK. - President, Kashmir Lung Society. - Member Editorial Board, JK Practitioner from January 2004 - Member Editorial Board, Kashmir Medical Journal from January 2004 PARTICIPATION AS INVITED SPEAKER OR CHAIRMAN - 42 National and International Scientific Meetings - 17 National and International Courses
Thesis work done on “Role of sigmoidoscopy and rectal biopsy in acute diarrheos” during MD.
Research work done on immunotherapy in COPD, therapeutics in asthma, effectiveness of DOT strategy in treatment of tuberculosis, Antimycobacterial Drug Resistance in Pulmonary Tuberculosis, High Resolution Computed Tomography Findings in asthma and COPD.
2
ORGANIZATIVE ACTIVITY - Member of Organizing Committee of 12 conferences and CMEs on internal medicine and pulmonology held in the Government Medical College, Srinagar. PUBLICATIONS - Author of 23 publications. GRANTS - No major supporting grants in the past five years
Dr.Mohammad Muzaffar Mirza
LIST OF PUBLICATIONS
1. Role of fibreoptic bronchoscopy in patients with hemoptysis and a normal chest roentenogram. Mohammad yousuf Kawoosa, Mohammad Muzaffar Mirza, Mushtaq Wani,Shammasuddin, Nazir Malik. Journal of Medical Sciences: 2003;6(1):36-41. Official publication of Sheri-I-Kashmir Institute of Medical Sciences.
2. Non invasive ventilation in COPD. Mohammad Muzaffar Mirza, Mushtaq Wani, Ghullam Hassan Dar. Indian Medical Journal:2004;32(2):66-71.
3. Comparison of Bronchoalveolar Lavage Fluid with Sputum Culture in Diagnosis of Sputum Smear Negative Pulmonary Tuberculosis.
Naveed Nazir Shah, Arshad Altaf Bachh, Rakesh Bhargava, Mohammad Muzaffar Mirza, Zuber Ahmed, D.K. Pandey, Mohd Shameem, Khurshid A Dar, Inaamul Haq.
Journal of Medical Sciences.2006;9(2):136-139. Official publication of Sheri-I-Kashmir Institute of Medical Sciences.
4. Bilateral Pneumothorax, Pneumomediastinum and Subcutaneous Emphysema–Rare Complications of Percutaneous Tracheostomy. Naveed Nazir Shah, Rakesh Bhargava, Zuber Ahmed, Mohd Shameem, Mohammad Muzaffar Mirza, Arshad Altaf Bachh, Khurshid Ahmad Dar, Nisar H Dar, Mir Mohsin. J K Practitioner. 2007;14(3):91-94. International Journal of Current Medical Science & Practice.
5. To study the effectiveness of DOTS at Chest Disease Hospital, Srinagar.
Mohammad Muzaffar Mirza, Naveed Nazir Shah, Mushtaq Ahmad Wani. Kashmir Medical Journal 2010; 24(2):128-131.
6. Endobronchial sclerotherapy for management of hemoptysis. Naveed Nazir Shah, Rakesh Bhargava, Zuber Ahmad , Quibtiya Syed, Khurshid Dar, Mohammad Shameem, Mohammad Muzaffar Mirza.
European Respiratory Journal 2008. 251s Official Publication of the European Respiratory Society.
7. Oral immunotherapy in preventing exacerbations of COPD. Naveed Nazir Shah, Rakesh Bhargava, Zuber Ahmed, Mohammad Shameem, Khurshid Ahmad Dar, Quibtiya Syed, Mohammad Muzaffar Mirza, Arshad Altaf Bachh. European Respiratory Journal 2008. 630s Official Publication of the European Respiratory Society.
8. Antimycobacterial Drug Resistance in Pulmonary Tuberculosis in Kashmir. Mohammad Muzaffar Mirza.
Kashmir Medical Journal 2009; 3: 49-53. 9. Extremely drug resistant tuberculosis-the danger ahead.
Mohammad Muzaffar Mirza. Journal of Medical Sciences.2009;9(2):136-138. Official publication of Sheri-I-Kashmir Institute of Medical Sciences.
10. Usefulness and Cost Effectiveness of Bronchial Washing in Diagnosing Endobronchial Malignancies.
Kashmir Medical Journal 2010; 3: 234-38.
Papers Accepted for Publication:
Unilateral Pulmonary Edema Resulting From Drainage of Spontaneous Pneumothorax. Naveed Nazir Shah, Rakesh Bhargava, Zuber Ahmed, DK Pandey, Mohammad Muzaffar Mirza, Mohd Shameem, Arshad Altaf Bachh, Khurshid A Dar.
In J K Practitioner. International Journal of Current Medical Science & Practice.
1
CURRICULUM VITAE - DR. STEFANO GASPARINI - Born in Ancona (Italy) (September 2, 1952) - Married, 1 son EDUCATION - Medical Degree at the University of Ancona (November 3, 1978) - Registered at the Medical Association of Province of Ancona (December, 1978) - Specialized in Pulmonary Diseases at the University of Neaples (July 1982) - Specialized in Respiratory Phisiopathology at the University of Neaples (July 1985) - Specialized in Anesthesiology and Intensive Care at the University of Ancona
(July 1990) PROFESSIONAL CAREER - 1 year teaching at the Pulmonary Division, Regional Hospital of Ancona (1979) - Medical Assistent of Pulmonary Division, Regional Hospital of Ancona, from March 1980 to May 1989 - Vice Head of Pulmonary Division, Regional Hospital of Ancona, from May 1989 - Director of Service of Thoracic Endoscopy of Pulmonary Division, Regional Hospital of Ancona, from April 1993 to present - Director of Pulmonary Diseases Unit of the Hospital of Ancona (Azienda
Ospedaliero-Universitaria Ospedali Riuniti) from June 2000 up today. ACADEMIC CAREER - Professor of Respiratory Medicine at the Ancona Medical School from 2006 MEMBERSHIP - Member of European Respiratory Society from 1981 - Member of Italian Society of Thoracic Endoscopy from 1988 - Member of Italian Association of Pulmonologists from 1990 - Fellow of American College of Chest Physician from 1994 - Fellow of American Thoracic Society from 1995 - Member of American Association for Bronchology from 1995 - Member of World Association for Bronchology from 1995 - Member of the European Association for Bronchology from 2002 - Member of International Association Study of Lung Cancer from 2008 HONORS - National Representative for Italy in the Advisory Council of World Association
for Bronchology (WAB) from 1995 - President Section Center Italy of Italian Association of Pulmonologists from 1995 - Chairman Regional Section Italian Society of Thoracic Endoscopy from 1990 - Chairman Thoracic Endoscopy Study Group of Italian Association of
Pulmonologist from 2000 to 2004 - Member Editorial Board Journal for Bronchology from January 2004 - Member Board of Directory World Association for Bronchology from 2004 - Member of Executive Committee of the Italian Association of Pulmonologist
from 2005
2
- Associate Editor of Respiration from 2007 - Secretary of the Study Group “Interventional Pulmonology” of the European
Respiratory Society (ERS) from 2009 PARTICIPATION AS INVITED SPEAKER OR CHAIRMAN - 231 National and International Scientific Meetings - 144 National and International Courses ORGANIZATIVE ACTIVITY - Member of Organizing Committee of 28th National Conference of Italian Association of Pulmonologists, Ancona, September 22-24, 1988 - Member of Organizing Committee and Scientific Secretary of 1st National
Course on "Bioptic techniques in the diagnosis of peripheral pulmonary lesions and mediastinal masses”, Ancona, September 27-30, 1989
- Member of Organizing Committee and Scientific Secretary of 2nd National Course on "Bioptic techniques in the diagnosis of peripheral pulmonary lesions and mediastinal masses”, Ancona, May 9-12, 1990
- Member of Organizing Committee and Scientific Secretary of National Conference of Thoracic Endoscopy, Ancona, May 8-9, 1992
- Co-Director of the 1st European Course on "Bioptic techniques in the diagnosis of peripheral pulmonary lesions and mediastinal masses”, Ancona, May 25-27, 1994 - Member of Scientific and Organising Committee of the 1st international Meeting
on Endoscopy of the Upper and Lower Airways, Ancona, June 18-21, 2003 - Organizer and Director of 27 Hands-on Courses in Interventional Pulmonology
held in Ancona from 2005 to 2010 PUBLICATIONS - Author of 233 pubblications. GRANTS - No major supporting grants in the past five years
1
DR. STEFANO GASPARINI
LIST OF LAST 10 YEARS PUBLICATIONS 1) “TRANSBRONCHIAL NEEDLE ASPIRATION OF MEDIASTINAL
LESIONS” S.Gasparini, L.Zuccatosta, M. De Nictolis Monaldi Arch Chest Dis 2000; 55: 29-32.
2) “LA PONCTION TRANSBRONCHIQUE DANS LE DIAGNOSTIC DES PROCESSUS EXPANSIFS DU MEDIASTIN” S.Gasparini, A. Bourdin La Lettre du Pneumologue 2000; 3: 9-13.
3) “THE UTILITY OF TRANSBRONCHIAL NEEDLE ASPIRATION IN THE
STAGING OF BRONCHOGENIC CARCINOMA” E.M.Harrow, W. Abi-Saleh, J. Blum, T. Harkin, S. Gasparini, D.J. Addrizzo-Harris, A.C.Arroliga, G. Wight, A.C.Mehta. Am J Respir Crit Care Med 2000; 161: 601-607.
4) “TRANSBRONCHIAL NEEDLE ASPIRATION IN THE EARLY DIAGNOSIS AND STAGING OF LUNG CANCER”
R. Chockani, S. Gasparini Indian J Allied Sci 2003; 45: 111-115. 5) “RISK ASSESSMENT OF PATIENTS WITH HEMATOLOGIC
MALIGNANCIES WHO DEVELOP FEVER ACCOMPANIED BY PULMONARY INFILTRATES”
M. Offidani, L. Corvatta, L. Malerba, M. Marconi, E. Bichisecchi, S. Cecchini, E. Manso, T. Principi, S. Gasparini, P. Leoni
Cancer 2004; 101:567-577. 6) “HEMOMEDIASTINUM AS A CONSEQUENCE OF TRANSBRONCHIAL
NEEDLE ASPIRATION” M. Talebian, L. Zuccatosta, A Recanatini and S. Gasparini J Bronchol 2004; 11: 178-181. 7) “USEFULNESS OF TRANSBRONCHIAL NEEDLE ASPIRATION IN
EVALUATING PATIENTS WITH LUNG CANCER” (Editorial). S.Gasparini, GA Silvestri Thorax 2005; 60: 890-89. 8) “IT IS TIME FOR THIS ROSE TO FLOWER” (Editorial) S.Gasparini Respiration 2005; 72: 129-131. 9) “AN UNUSUAL IATROGENIC FOREIGN BODY (SURGICAL GAUZE) IN
THE TRACHEA” R. Tabuena, L. Zuccatosta, A Tubaldi and S.Gasparini Respiration 2008; 75: 105-108
2
10) “ENDOSCOPIC ULTRASOUND-GUIDED BIOPSY IN THE CHEST” J. Jannsen, AC Mehta, S. Gasparini Eur Respir J 2006; 27: 238-239 11) “TRANSBRONCHIAL AND TRANSESOPHAGEAL (ULTRASOUND
GUIDED) NEEDLE ASPIRATIONS FOR THE ANALYSIS OF MEDIASTINAL LESIONS”
F.J.F. Herth, K.F. Rabe, S.Gasparini,J.T. Annema Eur Respir J 2006; 28: 1264-1275. 12) “EVOLVING ROLE OF INTERVENTIONAL PULMONOLOGY IN THE
INTERDISCIPLINARY APPROACH TO THE STAGING AND MANAGEMENT OF LUNG CANCER: BRONCHOSCOPIC MEDIASTINAL STAGING OF LUNG CANCER”
S. Gasparini Clinical Lung Cancer 2006; 8: 110-115. 13) “EXTENDED TRACHEAL RESECTION FOR CHONDROMA” F. Rea, G.Marulli, L.Bortolotti, F.Sartori, F.Calabrese, C.Giacometti,
G.Rizzardi, S.Gasparini Lung Cancer 2007; 55: 233-236. 14) “SAFETY OF PLEURODESIS WITH TALC POUDRAGE IN
MALIGNANT PLEURAL EFFUSION: A PROSPECTIVE COHORT STUDY” Janssen JP, Collier G, Astoul P, Tassi GF, Noppen M, Rodriguez-Panadero F,
Loddenkemper R, herth FJ, Gasparini S, Marquette CH, Becke B, Froudarakis ME, Driesden P, Bolliger CT, Tschopp JM
Lancet 2007; 369: 1535-1539 15) “GPS MAY HELP DRIVERS TO REACH THEIR DESTINATION, BUT THE
CAPABILITY TO DRIVE A CAR IS STILL NECESSARY. TRADITIONAL AND TECHNOLOGY-GUIDED TRANSBRONCHIAL NEEDLE ASPIRATION”. Editorial.
S. Gasparini Respiration 2007; 74: 379-381 16) “POST-INTUBATION TRACHEAL STENOSES: WHAT IS THE CURATIVE
YIELD OF THE INTERVENTIONAL PULMONOLOGY PROCEDURES?” M.Patelli, S.Gasparini Monaldi Arch Chest Dis 2007; 67: 71-72 17) “THE EVOLVING ROLE OF INTERVENTIONAL PULMONARY IN THE
INTERDISCIPLINARY APPROACH TO THE STAGING AND MANAGEMENT OF LUNG CANCER. PART III: DIAGNOSIS AND MANAGEMENT OF MALIGNANT PLEURAL EFFUSIONS”
KY Yoneda, PN Mathur, S Gasparini Clinical Lung Cancer 2007; 8: 535-547
3
18) “PILOT FEASIBILITY STUDY OF TRANSBRONCHIAL NEEDLE FORCEPS. A NEW TOOL FOR OBTAINING HISTOLOGY SAMPLES FROM MEDIASTINAL SUBCARINAL LYMPH NODES” S Gasparini, L Zuccatosta, M Sediari, F Mei J Bronchol Intervent Pulmonol 2009; 16: 183-187
19) “SILVER NITRATE THROUGH FLEXIBLE BRONCHOSCOPE IN THE
TREATMENT OF BRONCHOPLEURAL FISTULAE” G Stratakos, L Zuccatosta, I Porfyridis, M Sediari, C Zisis, V Mariatou, E Kostopoulos, A Psevdi, S Zakynthinos and S Gasparini J Thorac Cardiovasc Surg 2009; 138: 603-607
20) “CLINICAL PREDICTIVE FACTORS FOR ADVANCED NON-SMALL CELL LUNG CANCER (NSCLC) PATIENTS RECEIVING THIRD-LINE THERAPY: SELECTING THE UNRESECTABLE?” M Scartozzi, P Mazzanti, R Giampieri, R Berardi, E Galizia, S Gasparini, L Zuccatosta and S Cascinu Lung Cancer 2009. E-pub ahead of print.
21) “STENTING RIGHT MAIN BRONCHUS WITH MONTGOMERY T TUBE FOR UPPER LOBE VENTILATION” Vikrant Deshmukh, Lina Zuccatosta, Michele Sediari, Federico Mei, Stefano Gasparini, Luca Salvolini J Bronchol Intervent Pulmonol 2010; 17: 90-92
22) “HISTOLOGY VERSUS CYTOLOGY IN THE DIAGNOSIS OF LUNG CANCER. IT IS A REAL ADVANTAGE?” Stefano Gasparini J Bronchol Intervent Pulmonol 2010; 17: 103-105
23) “WHILE WAITING TO BUY A FERRARI, DO NOT LEAVE YOUR
CURRENT CARE IN THE GARAGE!” (Editorial) R Trisolini, M Patelli, S Gasparini Respiration 2010; 79: 452-453
24) “DIAGNOSTIC MANAGEMENT OF SOLITARY PULMONARY NODULES”
Stefano Gasparini Eur Respir Mon 2010; 48: 90-108
