EXTRA EXCELLENCE EXPERIENCE EXCLUSIVE EXPERTISE EXCEPTIONAL EXTRA EXCELLENCE EXPERIENCE SIVE EXPERTISE EXCEPTIONAL EXTRA EXCELLENCE EXPERIENCE EXCLUSIVE EXPERTISE EXCEPTIONALEXTRA EXCELLENCE EXPERIENCE EXCLUSIVE EXPERTISE EXCEPTIONAL EXTRA EXCELLENCE EXCLUSIVE EXPERTISE EXCEPTIONAL EXPERIENCE EXTRA EXCLUSIVE EXPERTISE EXCEPTIONAL EXTRA EXCELLENCE EXPERIENCE EXCLUSIVE EXPERTISE EXPERIENCE EXTRA EXCELLEN EXPERIENCE EXCLUSIVE EXPERTISE EXCEPTIONAL EXTRA EXCELLENCE EXPERIENCE EXPERTISE EXCEPTIONAL EXTRA EXCELLENCE EXPERIENCE EXCLUSIVE EXPERTISE EXCEPTIONAL EXTRA EXCELLENCE EXPERIENCE EXCLUSIVE EXPERTISE EXCEPTIONAL EXTRA EXCELLENCE EXPERIENCE SIVE EXPERTISE EXCEPTIONAL EXTRA EXCELLENCE EXPERIENCE EXCLUSIVE EXPERTISE EXCEPTIONALEXTRA EXCELLENCE EXPERIENCE EXCLUSIVE EXPERTISE EXCEPTIONAL EXTRA EXCELLENCE EXCLUSIVE EXPERTISE EXCEPTIONAL EXPERIENCE EXTRA EXCLUSIVE EXPERTISE EXCEPTIONAL EXTRA EXCELLENCE EXPERIENCE EXCLUSIVE EXPERTISE EXPERIENCE EXTRA EXCELLEN EXPERIENCE EXCLUSIVE EXPERTISE EXCEPTIONAL EXTRA EXCELLENCE EXPERIENCE EXPERTISE EXCEPTIONAL EXTRA EXCELLENCE EXPERIENCE EXCLUSIVE EXPERTISE EXCEPTIONAL EXTRA EXCELLENCE EXPERIENCE EXCLUSIVE EXPERTISE EXCEPTIONAL EXTRA EXCELLENCE EXPERIENCE SIVE EXPERTISE EXCEPTIONAL EXTRA EXCELLENCE EXPERIENCE EXCLUSIVE EXPERTISE EXCEPTIONALEXTRA EXCELLENCE EXPERIENCE EXCLUSIVE EXPERTISE EXCEPTIONAL EXTRA EXCELLENCE EXCLUSIVE EXPERTISE EXCEPTIONAL EXPERIENCE EXTRA EXCLUSIVE EXPERTISE EXCEPTIONAL EXTRA EXCELLENCE EXPERIENCE EXCLUSIVE EXPERTISE EXPERIENCE EXTRA EXCELLEN EXPERIENCE EXCLUSIVE EXPERTISE EXCEPTIONAL EXTRA EXCELLENCE EXPERIENCE EXPERTISE EXCEPTIONAL EXTRA EXCELLENCE EXPERIENCE EXCLUSIVE EXPERTISE EXCEPTIONAL EXTRA EXCELLENCE EXPERIENCE EXCLUSIVE EXPERTISE EXCEPTIONAL EXTRA EXCELLENCE EXPERIENCE SIVE EXPERTISE EXCEPTIONAL EXTRA EXCELLENCE EXPERIENCE EXCLUSIVE EXPERTISE EXCEPTIONALEXTRA EXCELLENCE EXPERIENCE EXCLUSIVE EXPERTISE EXCEPTIONAL EXTRA EXCELLENCE EXCLUSIVE EXPERTISE EXCEPTIONAL EXPERIENCE EXTRA EXCLUSIVE EXPERTISE EXCEPTIONAL EXTRA EXCELLENCE EXPERIENCE EXCLUSIVE EXPERTISE EXPERIENCE EXTRA EXCELLEN EXPERIENCE EXCLUSIVE EXPERTISE EXCEPTIONAL EXTRA EXCELLENCE EXPERIENCE EXPERTISE EXCEPTIONAL EXTRA EXCELLENCE EXPERIENCE EXCLUSIVE EXPERTISE EXCEPTIONAL EXTRA EXCELLENCE EXPERIENCE EXCLUSIVE EXPERTISE EXCEPTIONAL EXTRA EXCELLENCE EXPERIENCE SIVE EXPERTISE EXCEPTIONAL EXTRA EXCELLENCE EXPERIENCE EXCLUSIVE EXPERTISE EXCEPTIONALEXTRA EXCELLENCE EXPERIENCE EXCLUSIVE EXPERTISE EXCEPTIONAL EXTRA EXCELLENCE EXCLUSIVE EXPERTISE EXCEPTIONAL EXPERIENCE EXTRA EXCLUSIVE EXPERTISE EXCEPTIONAL EXTRA EXCELLENCE EXPERIENCE EXCLUSIVE EXPERTISE EXPERIENCE EXTRA EXCELLEN EXPERIENCE EXCLUSIVE EXPERTISE EXCEPTIONAL EXTRA EXCELLENCE EXPERIENCE EXPERTISE EXCEPTIONAL EXTRA EXCELLENCE EXPERIENCE EXCLUSIVE EXPERTISE EXCEPTIONAL EXTRA EXCELLENCE EXPERIENCE EXCLUSIVE EXPERTISE EXCEPTIONAL EXTRA EXCELLENCE EXPERIENCE SIVE EXPERTISE EXCEPTIONAL EXTRA EXCELLENCE EXPERIENCE EXCLUSIVE EXPERTISE EXCEPTIONALEXTRA EXCELLENCE EXPERIENCE EXCLUSIVE EXPERTISE EXCEPTIONAL EXTRA EXCELLENCE EXCLUSIVE EXPERTISE EXCEPTIONAL EXPERIENCE EXTRA EXCLUSIVE EXPERTISE EXCEPTIONAL EXTRA EXCELLENCE EXPERIENCE EXCLUSIVE EXPERTISE EXPERIENCE EXTRA EXCELLEN EXPERIENCE EXCLUSIVE EXPERTISE EXCEPTIONAL EXTRA EXCELLENCE EXPERIENCE EXPERTISE EXCEPTIONAL EXTRA EXCELLENCE EXPERIENCE EXCLUSIVE EXPERTISE EXCEPTIONAL EXTRA EXCELLENCE EXPERIENCE EXCLUSIVE EXPERTISE EXCEPTIONAL EXTRA EXCELLENCE EXPERIENCE SIVE EXPERTISE EXCEPTIONAL EXTRA EXCELLENCE EXPERIENCE EXCLUSIVE EXPERTISE EXCEPTIONALEXTRA EXCELLENCE EXPERIENCE EXCLUSIVE EXPERTISE EXCEPTIONAL EXTRA EXCELLENCE EXCLUSIVE EXPERTISE EXCEPTIONAL EXPERIENCE EXTRA EXCLUSIVE EXPERTISE EXCEPTIONAL EXTRA EXCELLENCE EXPERIENCE EXCLUSIVE EXPERTISE EXPERIENCE EXTRA EXCELLEN EXPERIENCE EXCLUSIVE EXPERTISE EXCEPTIONAL EXTRA EXCELLENCE EXPERIENCE EXPERTISE EXCEPTIONAL EXTRA EXCELLENCE EXPERIENCE EXCLUSIVE EXPERTISE EXCEPTIONAL EXTRA EXCELLENCE EXPERIENCE EXCLUSIVE EXPERTISE EXCEPTIONAL EXTRA EXCELLENCE EXPERIENCE SIVE EXPERTISE EXCEPTIONAL EXTRA EXCELLENCE EXPERIENCE EXCLUSIVE EXPERTISE EXCEPTIONALEXTRA EXCELLENCE EXPERIENCE EXCLUSIVE EXPERTISE EXCEPTIONAL EXTRA EXCELLENCE EXCLUSIVE EXPERTISE EXCEPTIONAL EXPERIENCE EXTRA EXCLUSIVE EXPERTISE EXCEPTIONAL EXTRA EXCELLENCE EXPERIENCE EXCLUSIVE EXPERTISE EXPERIENCE EXTRA EXCELLEN EXPERIENCE EXCLUSIVE EXPERTISE EXCEPTIONAL EXTRA EXCELLENCE EXPERIENCE EXPERTISE EXCEPTIONAL EXTRA EXCELLENCE EXPERIENCE EXCLUSIVE EXPERTISE EXCEPTIONAL

C E F T I O F U R I N P O W D E R F O R I N J E C TA B L E S O L U T I O N

(1) SARAH A, SALMON SA, WATTS JL, YANCEY RJ JR. In vitro activity of ceftiofur and its primary metabolite, desfuroylceftiofur, against organisms of veterinary importance.

J Vet Diagn Invest. 8(3):332-6. 1996. (2) BROES A, MARTINEAU GP, GOTTSCHALK M.

Dealing with unexpected Actinobacillus pleuropneumoniae serological results. J of Swine Health and Production 15(5): 264-9. 2007.(3) WISSELINK HJ, VELDMAN KT, VAN DEN EEDE C, SALMON SA, MEVIUS DJ.

Quantitative susceptibility of Streptococcus suis strains isolated from diseased pigs in seven european countries to antimicrobial agents licenced in veterinary medicine. Vet Mic. 113 : 73-82. 2006.

CEVAXEL® 50 mg/ml: powder and solvent for solution for injection for cattle and pigs. COMPOSITION: Powder vials contains: Ceftiofur (as sodium) 1 g or 4 g One ml solvent contains: Water for injections 1 ml INDICATIONS: Cattle: treatment of bacterial respiratory disease associated with Pasteurella multocida and Mannheimia haemolytica sensitive to ceftiofur. Treatment of cattle with interdigital necrobacillosis (foot rot) in which Fusobacterium necrophorum and Bacteroides melaninogenicus (Porphyromonas asaccharolytica) sensitive to ceftiofur are involved. Pigs: treatment of bacterial respiratory disease in which Pasteurella multocida, Actinobacillus pleuropneumonia and Streptococcus suis sensitive to ceftiofur are involved. AMOUNTS TO BE ADMINISTERED AND ADMINISTRATION ROUTE: Intramuscular use. Cattle: For respiratory disease: 1 mg ceftiofur (as sodium) per kg bodyweight per day for 3 to 5 days, i.e. 1 ml of reconstituted solution per 50 kg bodyweight per day for 3 to 5 days. For interdigital necrobacillosis: 1 mg ceftiofur (as sodium) per kg bodyweight per day for 3 days, i.e. 1 ml of reconstituted solution per 50 kg bodyweight per day for 3 days. Pigs: 3 mg ceftiofur (as sodium) per kg bodyweight per day for 3 days, i.e. 1 ml of reconstituted solution per 16 kg bodyweight per day for 3 days. WITHDRAWAL PERIODS: Meat and offal: Cattle: 2 days. Pigs: 2 days. Milk: zero days. CONTRAINDICATIONS: Do not use in animals previously found to be hypersensitive to ceftiofur or other beta-lactamines. ADVERSE REACTIONS: Fleeting symptoms of pain may be observed at the injection site. Hypersensitivity reactions can occasionally occur. In the case of an allergic reaction, treatment should be stopped. LEGAL CATEGORY: List I. Use only under veterinary prescription. PACK SIZES: Box containing 1 vial of CEVAXEL 50 mg/ml 1 g and box containing a vial of 20 ml solvent. AMM N° XXXXXXX Box containing 1 vial of CEVAXEL 50 mg/ml, 4 g and box containing a vial of 80 ml solvent. AMM N° XXXXXXX. Not all pack sizes may be marketed.

ExPERTISE

Your first choice antibiotic

Supplied with its solvent

ExCLUSIvE

Cost effective

ExT RA

C E F T I O F U R I N P O W D E R F O R I N J E C TA B L E S O L U T I O N

CEVA SANTÉ ANIMALE S.A. La Ballastière - B.P. 126 - 33501 Libourne Cedex - FranceTél : 33(0)5 57 55 40 40 - Fax : +33 (0)5 57 55 41 98www.ceva.com - Mail : contact @ ceva.com

ExPERIENCE

BEYOND ExC...ellence!

ExC LUSIvITYYOU NO LONGER HAVE TO PAY fOR

0

Time (h)

Pla

sma

Con

c. (m

g/L)

Treatment A (Test item)

Treatment B (Reference item)

16

12

8

6

10

14

18

4

2

0 2 4 6 8 10 12 14 16 18 20 22 24 26 28 30

Evolution of plasmatic concEntrations in pigs aftEr injEction of 2 diffErEnt prEparations of cEftiofur a = cEvaXEl® - B = rEfErEncE cEftiofur

CEVA has A long eXPerIence in manufacturing injectable anti-infectives in its modern GMP plant.

CEVA has A gooD know How in developing differentiated generics in antibiotherapy.

CEVAxEL has shown

ItS Perfect bIoeQuIVAlence

compared to the reference product.

CEVAxEL IS ABSORBED qUICKLY AT THE INJECTION SITE, REACHING PEAK PLASMA LEVELS IN LESS THAN ONE HOUR. MOREOVER, CONCENTRATIONS REMAIN ABOVE THE MICS fOR 24 Hrs.

CE EXPERIENCE EXCLUSIVE EXPERTISE EXCEPTIONALEXTRA EXCELLENCE EXCEPTIONAL EXTRA EXCELLENCE EXPERIENCE EXCLUSIVE EXPERTISE EXCECE EXPERIENCE EXCLUSIVE EXPERTISE EXCEPTIONAL EXTRA EXCELLENCE EPTIONAL EXTRA EXCELLENCE EXPERIENCE EXCLUSIVE EXPERTISE EXCEPTCE EXPERIENCE EXCLUSIVE EXPERTISE EXCEPTIONAL EXTRA EXCELLENCE PERTISE EXCEPTIONAL EXTRA EXCELLENCE EXPERIENCE EXCLUSIVE EXPER

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XCEPTIONAL EXTRA EXCELLENCE EXPERIENCE EXCLUSIVE EXPERTISE EXCECE EXPERIENCE EXCLUSIVE EXPERTISE EXCEPTIONAL EXTRA EXCELLENCE XCELLENCE EXPERIENCE EXCLUSIVE EXPERTISE EXCEPTIONAL EXTRA EXCEENCE EXCLUSIVE EXPERTISE EXCEPTIONAL EXTRA EXCELLENCE EXPERIENCPERTISE EXCEPTIONAL EXTRA EXCELLENCE EXPERIENCE EXCLUSIVE EXPERCE EXPERIENCE EXCLUSIVE EXPERTISE EXCEPTIONALEXTRA EXCELLENCE E

XCEPTIONAL EXTRA EXCELLENCE EXPERIENCE EXCLUSIVE EXPERTISE EXCE

BEYONDExC...ellence!

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GOOD ExTRACELLULAR

DIffUSION AND TOTAL

BIOAVAILABILITY Of CEfTIOfUR

only two days withdrawal pEriod for mEat and offal

BEYOND ExC...ellence!

Porcine Respiratory Disease(PASTEURELLA mULTOC IDA , ACT INOBAC I LLUS PLEUROPNEUmON IAE

AND STREPTOCOCCUS SU I S ) .

PASTEURELLA MULTOCIDA : typical secondary bacteria contributing to the development of complicated enzootic pneumonia of growing and fattening pigs.

ACTINOBACILLUS PLEUROPNEUMONIAE (APP) : a frequent worldwide spread primary infection, which can cause significant direct and indirect losses. The mortality after infection of susceptible animals can reach 50%(2).

STREPTOCOCCUS SUIS : most common pathogen involved in mixed respiratory viral and bacterial coinfections(3).

, TO HELP YOU to fIgHt AgAInSt :

ExCLUSIVELYsupplied with its solvent

pig nEck musclE

24h aftEr injEction of cEvaXEl. Moreover, Cevaxel did not impared general behaviour, appetite and weight gain.

. In the 14 days following injection, no clinical signs like pain, swelling,

erythema and induration have been reported..No macroscopic lesions were observed.

LESS STRESS fOR SUCKLING PIGLETS

ExCELLENT locAl tolerAnce

AT THE INJECTION POINT fOLLOWING INTRAMUSCULAR ADMINISTRATION Of CEVAxEL(Tolerance study, CEVA file)

RECONSTITUTION Of THE PRODUCT

POWDERSOLVENT1. 2. 3. 4.

1. fILL THE SYRINGE WITH THE REqUIRED qUANTITY Of SOLVENT

2. INJECT THE SOLVENT IN THE VIAL Of POWDER UNTIL THE SYRINGE RESISTS

3. RELEASE THE PISTON IN A WAY THAT THE AIR BRINGS IN THE SYRINGE

4. RE-INJECT THE REST Of THE SOLVENT

. Ceftiofur belongs to the 3rd generation of cephalosporins

. With bactericidal properties related to the inhibition of bacteria cell wall synthesis

. Wide spectrum against Gram + and Gram - bacteria(1)

CEFTIOFUR: TO ExCEL in antibiotherapy

CEfTIOfUR, A WIDE RANGE

Of ACTIONS AGAINST SWINE

PATHOGENS

ExT RA ExPERTISE ExCEPTIONAL

CEVAxEL IS A SAfE AND TISSUE fRIENDLY PRODUCT

0 % 20 % 40 % 60 % 80 % 100 %

Pasteurella multocida(171 isolated strains)

Actinobacillus pleuropneumoniæ (133)

Streptococcus suis (62)

SUSCEPTIBILITY Of THE MAIN ISOLATED PATHOGENS

intErnal cEva studiEs, 2007

AnaerobiaeGram +

Cl. Perfringens

AnaerobiaeGram -

Enterobacter(E.Coli)

Actinobacilluspleuropneumoniae

Pasteurella multocida

Streptococcussuis

Ceftiofur X X X X X X

Tulathromycine X X No X X X

Spectinomycine X X +/- X +/- +/-

Enrofloxacine +/- +/- X X X X

fOR MORE

PRACTICAL USE