ERICH GROTEWOLD, Ph · P., and Grotewold. (2012) A genome-wide regulatory framework identifies maize ... L.* (2012) A regulatory switch enforced by bHLH and ACT domain-mediated dimerizations

Erich Grotewold

1

ERICH GROTEWOLD, Ph.D.

CURRICULUM VITAE

PRESENT ADDRESS Center for Applied Plant Sciences

206 Rightmire Hall, 1060 Carmack Road

The Ohio State University, Columbus, OH 43210

Phone: (614) 292-2483, FAX: (614) 292-5379, E-mail: [email protected]

EDUCATION 1985-1988 Ph.D., Chemistry, Instituto de Ingeniería Genética y Biología Molecular,

and University of Buenos Aires, Buenos Aires, Argentina.

1981-1985 B.Sc., Chemistry, Faculty of Science, University of Buenos Aires,

Argentina

POSTDOCTORAL TRAINING

1989 - 1993 Post-Doctoral Research Fellow, Cold Spring Harbor Laboratory, Cold

Spring Harbor, NY.

ACADEMIC APPOINTMENTS 10/11 – present Director, Center for Applied Plant Sciences (CAPS), The Ohio State

University, Columbus, OH.

8/09 - present Director, Arabidopsis Biological Resource Center (ABRC), The Ohio

State University, Columbus, OH.

9/06 – present Professor, Department of Molecular Genetics (previously Plant Cellular

and Molecular Biology) and Department of Horticulture and Crop

Sciences, The Ohio State University, Columbus, OH.

9/07 - 6/08 Visiting Professor, Mathematical Bioscience Institute, The Ohio State


2001 – 2006 Associate Professor, Department of Plant Cellular & Molecular Biology

And Department of Horticulture and Crop Sciences, The Ohio State


1997 - 2001 Assistant Professor, Department of Plant Biology and Department of

Horticulture and Crop Sciences, The Ohio State University, Columbus,

OH.

1995 - 1997 Assistant Investigator, Cold Spring Harbor Laboratory, Cold Spring

Harbor, NY.

1993 - 1995 Staff Associate, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.

1989 - 1993 Post-Doctoral Research Fellow, Cold Spring Harbor Laboratory, Cold

Spring Harbor, NY.

CONSULTING POSITIONS

1/04 – 12/05 Consultant CERES, Inc. Thousand Oaks, CA.

Erich Grotewold

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HONORS AND AWARDS

2009 Elected Fellow of the American Association for the Advancement of

Science (AAAS)

2006 Dean’s Award for Excellence in Undergraduate Research Mentoring

1995 Demerec-Kaufmann-Hollaender Fellow in Developmental Genetics

1989 - 1990 Long Island Biological Association Fellow

1986 - 1989 Fellow of the National Research Council of Argentina

1985 - 1986 University of Buenos Aires Fellow

EDITORIAL BOARDS

2011 – present Editor-in-Chief, Plant Science

2011 – present Member Review Editorial Board of Frontiers in Plant Metabolism and

Chemodiversity

2010 – present Editor, Biochemistry and Physiology Section, BMC Plant Biology

2011 – present Editorial Board, Scientific Reports

2010 – present Honorary Editorial Board, Research and Reports in Biology

2010 – present Member Review Editorial Board, Frontiers in Plant Physiology

2009 – present Editorial Board, BBA – Gene Regulatory Mechanisms

2009 – 2010 Editorial Board, Plant Science Journal

2008 – 2010 Associate Editor, BMC Plant Biology Journal

2005 – 2008 Member Editorial Board, BMC Plant Biology Journal

2007 – 2008 Guest Co-Editor, 2008 Plant Issue of Current Opinions in Biotechnology

2006 – 2010 Member, Faculty of 1000 Plant Biology (http://www.f1000biology.com/)

2005 – 2008 Member Editorial Board, Molecular Biotechnology

2004 – 2005 Editorial Board, MaizeGDB (http://www.maizegdb.org/)

SCIENTIFIC CONFERENCE ORGANIZER

6/10 Co-Chair, Ohio Conference Computational Biology (OCCBIO).

Columbus, OH.

4/09 Co-Chair, The DNA-Proteome: Recent Advance Towards Establishing the

Protein-DNA Interaction Space. Barcelona BioMed Conference, Spain.

7/07 Co-Founder and Co-Chair Gordon Kenan Research Seminars in Plant

Metabolic Engineering, Tilton, NH

7/07 Chair, Gordon Research Conference in Plant Metabolic Engineering,

Tilton, NH

7/05 Co-Founder and Co-Chair, Gordon Research Conference in Plant

Metabolic Engineering, Tilton, NH

8/03 Chairperson, Symposium on Maize Phytochemicals at the Phytochemical

Society of North America Annual Conference, Peoria, IL

7/03 – 7/04, 7/10 Member, Scientific Program Committee for the 2004 & 2010 International

Workshop on Anthocyanins.

http://www.f1000biology.com/

Erich Grotewold

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WORKSHOP ORGANIZER

7/05 and 7/10 Organizer and Director, Practical Summer Workshop in Functional

Genomics, The Ohio State University, Columbus, OH

MEMBERSHIPS AND OFFICES IN PROFESSIONAL SOCIETIES

2009 - Member, American Association for the Advancement of Science

2004 - Member, American Society for Biochemistry and Molecular Biology

2002 - Member, Phytochemical Society of North America

2000 - Member, American Society of Cell Biology

1997 - Member, Genetics Society of America

1997 - Member, American Society of Plant Biology

PEER REVIEWED PUBLICATIONS

1. Morohashi, K., Casas, M.I., Ferreyra, M.F., Mejía-Guerra, M.K., Pourcel, L., Yilmaz, A.,

Feller, A., Carvalho, B., Emiliani, J., Rodriguez, E., Pellegrinet, S., McMullen, M., Casati,

P., and Grotewold. (2012) A genome-wide regulatory framework identifies maize

Pericarp Color1 (P1) controlled genes. Plant Cell, In Press.

2. Kong, Q., Pattanaik, S., Feller, A., Werkman, J.R., Chai, C., Wang, Y., Grotewold, E.*,

and Yuan, L.* (2012) A regulatory switch enforced by bHLH and ACT domain-mediated

dimerizations of the maize transcription factor R. Proc. Natl. Acad. Sci. USA. In Press.

3. Bolduc, N., Yilmaz, A., Mejia-Guerra, M.K., Morohashi, K., O’Connor, D., Grotewold, E.

and Hake, S. (2012) Unraveling the KNOTTED1 regulatory network in maize meristems.

Genes & Dev. accepted pending minor revisions.

4. Rius, S., Grotewold, E., and Casati, P. (2012) Analysis of the P1 promoter in response to UV-

B radiation in allelic variants of high-altitude maize. BMC Plant Biology 12: 92.

5. Falcone-Ferreyra, M.L., Casas, M.I., Questa, Q., Herrera, L., Deblasio, S., Wang, J., Jackson,

D., Grotewold, E., and Casati., P. (2012) Evolution and expression of tandem duplicated

maize flavonol synthase genes. Frontiers Plant Gen. & Genom. 3: Article 101.

6. Sharma, M., Chai, C., Morohashi, K., Grotewold, E., Snook, M.E., and Chopra, S. (2012)

Maize flavonoid 3' hydroxylase is required for multiple branches of phlobaphene

biosynthetic pathway. BMC Plant Biology, accepted pending revisions.

7. Cannon, E.K.S., Birkett, S.M., Braun, B.L., Kodavali, S., Jennewein, D.M., Yilmaz, A.,

Antonescu, V., Antonescu, C., Harper, L.C., Gardiner, J.M., Schaeffer, M.L., Campbell,

D.A., Andorf, C.M., Andorf, D., Lisch, D.R., Koch, K.E., McCarty, D., Lawrence, C.J.

(2011) POPcorn: an online resource providing access to distributed and diverse maize

project data. Intl. J. Plant Genomics 2011: ID923035.

8. Beeckman, T., Vanneste, S., Coppens, F., Lee, E., Donner, T., Xie, A., Van Isterdael, G.,

Dhondt, S., De Winter, F., De Rybel, B., De Veylder, L., Friml, J., Inze, D., Grotewold,

G., Scarpella, E., Sack, F., Beemster, G., and Vuylsteke., M. (2011) Developmental

regulation of CYCA2s contributes to tissue-specific proliferation in Arabidopsis. EMBO J.

30: 3430-3441.

Erich Grotewold

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9. Machemer, K., Shaiman, O., Salts, Y., Shabtai, S., Sobolev, I., Belausov, E., Grotewold, E.,

and Barg, R. (2011) MYB factors interplay in differential cell expansion and

consequences for tomato fruit development. Plant J. 68: 337-350.

10. Anastasio, A.E., Platt, A., Horton, M., Grotewold, E., Scholl, R., Borevitz, J.O., Nordborg,

M., and Bergelson, J. (2011) Source verification of misidentified Arabidopsis thaliana

accessions. Plant J. 67: 554-566.

11. Siegal-Gaskins, D., Mejia-Guerra, M.K., Smith, G.D., and Grotewold, E. (2011) Emergence

of switch-like behavior in a large family of simple biochemical networks. PLoS Comp

Biol. 7: e1002039.

12. Yilmaz, A., Mejia-Guerra, M.K., Kurz, K., Liang, X., Welch, L., Grotewold, E. (2011)

Arabidopsis Gene Regulatory Information Server, an update. Nucl Acids Res. 39: D1118-

1122.

13. Fornale, S., Shi, X., Chai, C., Encina, A., Irar, S., Capellades, M., Fuguet, E., Torres, J-L.,

Rovira, P., Puigdomenech, P., Rigau, J., Grotewold, E., Gray, J., and Caparros-Ruiz, D.

(2010). ZmMYB31 directly represses maize lignin genes and redirects the

phenylpropanoid metabolic flux. Plant J. 64: 633-644.

14. Xie, Z., Li, D., Wang, L., Sack, F., and Grotewold, E. (2010). Role of the stomatal

development regulators FLP/MYB88 in abiotic stress responses. Plant J. 64: 731-739.

15. Xie, Z., Lee, E., Lucas, J.R., Morohashi, K., Li, D., Murray, J.A.H., Sack, F.D., and

Grotewold, E. (2010). Regulation of stomatal lineage cell proliferation by the Arabidopsis

MYB four lips via direct targeting of core cell cycle genes. Plant Cell 22: 2306-2321.

16. Falcone Ferreyra, M., Rius, S., Emiliani, J., Pourcel, L., Feller, A., Morohashi, K., Casati, P.,

and Grotewold, E. (2010). Cloning and characterization of a UV-B inducible maize

flavonol synthase. Plant J. 62: 77-91.

17. The International Brachypodium Initiative. (2010) Genome sequence and analysis of the

model grass Brachypodium distachyon. Nature 463: 763-768.

18. Pourcel, L. Irani, NG, Lu, Y., Riedl, K., Schwartz, S., and Grotewold, E. (2010) The

formation of anthocyanic vacuolar inclusions in Arabidopsis thaliana and implications for

the sequestration of anthocyanin pigments. Molecular Plant 3: 78-90.

19. Lichtenberg, J., Yilmaz, A., Welch, J.D., Kurz, K., Liang, X., Drews, F., Ecker, K., Lee, S.S.,

Geisler, M., Grotewold E., and Welch, L.R. (2009) The word landscape of the non-coding

segments of the Arabidopsis thaliana genome. BMC Genomics 10: 463.

20. Siegal-Gaskins, D., Grotewold, E., and Smith, G.D. (2009) The capacity for multistability in

small gene regulatory networks. BMC Syst. Biol. 3: 96.

21. Gray, J., Bevan, M., Brutnell, T., Buell, R., Cone, K., Hake, S., Jackson, D., Kellogg, E.A.,

Lawrence, C., McCouch, S., Mockler, T., Moose, S.P., Paterson, A., Peterson, T.,

Rokshar, D., Souza, G.M., Springer, N., Stein, N., Timmermans, M.C., Wang, G.-L., and

Grotewold, E. (2009) A recommendation for naming transcription factor proteins in the

grasses. Plant Physiol.149: 4-6.

22. Morohashi, K. and Grotewold, E. (2009) A systems approach reveals regulatory circuitry for

Arabidopsis trichome initiation by the GL3 and GL1 selectors. PLoS Genetics. 5:

e1000396.

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23. Yilmaz, A., Nishiyama, M.Y., Garcia-Fuentes, B., Souza, G.M., Janies, D., Gray,

J. and

Grotewold, E. (2009) GRASSIUS: A platform for comparative regulatory genomics

across the grasses. Plant Physiol. 149: 171-180.

24. Xie, Z., and Grotewold, E. (2008) Serial ChIP as a tool to investigate the co-localization or

exclusion of proteins on plant genes. Plant Methods 4: 25.

25. Zhao, M., Morohashi, K., Hatlestad, G., Grotewold, E. and Lloyd, A. (2008) The TTG1-

bHLH-MYB complex controls trichome cell fate and patterning through direct targeting of

regulatory loci. Development 135: 1991-1999.

26. Poustka, F., Irani, N.G., Feller, A., Lu, Y., Pourcel, L., Frame, K., Grotewold, E. (2007) A

trafficking pathway for anthocyanins overlaps with the endoplasmic reticulum-to-vacuole

protein sorting route in Arabidopsis and contributes to the formation of vacuolar

inclusions. Plant Physiol. 145: 1323-1335.

27. Hernandez, J.M., Feller, A., Morohashi, K., Frame, K. and Grotewold, E. (2007) The bHLH

domain of maize R links transcriptional regulation and histone modifications by

recruitment of an EMSY-related factor. Proc. Natl. Acad. Sci. USA. 104: 17222-17227.

28. Morohashi, K., Zhao, M., Yang, M., Read, B., Lloyd, A., Lamb, R., and Grotewold, E.

(2007) Participation of the Arabidopsis bHLH factor GL3 in trichome initiation regulatory

events. Plant Physiol. 145: 736-746.

29. Nicholas, C., Batra, S., Vargo, M.A., Voss, O.H., Gavrilin, M., Wewers, M.D., Guttdridge,

D.C., Grotewold, E., and Doseff, A.I. (2007) Apigenin blocks lipopolysaccharide-induced

lethality in vivo and pro-inflammatory cytokines expression by inactivating NF-B

through the suppression of p65 phosphorylation. J. Immunol. 179: 7121-7127.

30. Heine, G.F., Malik, V., Dias, A.P., and Grotewold, E. (2007) Expression and molecular

characterization of ZmMYB-IF35 and related R2R3-MYB transcription factors. Mol.

Biotech. 37: 155-164.

31. Serpa, V., Vernal, J., Lamattina, L., Grotewold, E., Cassia, R., Terenzi, H. (2007) Inhibition

of AtMYB2 DNA-binding by nitric oxide involves cysteine S-nitrosylation. Biochem.

Biophys Res. Comm. 361: 1048-1053.

32. Cheng, L., Xu, Y., Grotewold, E., Jin, Z., Wu, F., Fu, C., and Zhao, D. (2007)

Characterization of anthocyanidin synthase (ANS) gene and anthocyanidin in rare

medicinal plant - Saussurea medusa. Plant Cell. Tiss. Organ Cult. 89: 63–73.

33. Feller, A., Hernandez, J.M., and Grotewold, E. (2006) An ACT domain participates in the

dimerization of several plant bHLH transcription factors. J. Biol. Chem. 281: 28964 –

28974.

34. Vargo, M.A., Voss, O.H., Poustka, F., Cardounel, A.J., Grotewold, E., and Doseff, A.I.

(2006) Apigenin-induced-apoptosis is mediated by the activation of PKC and caspases in

leukemia cells. Biochem. Pharmacol. 72: 681-692.

35. Palaniswamy, K., James, S., Sun, H., Lamb, R., Davuluri, R.V. and Grotewold, E. (2006)

AGRIS and AtRegNet: A platform to link cis-regulatory elements and transcription factors

into regulatory networks. Plant Phyisiol. 140: 818-829.

36. Lu, Y., Irani, N.G., and Grotewold, E. (2005) Covalent attachment of the plant natural

product naringenin to small glass and ceramic beads. BMC Chemical Biology 5: 3.

Erich Grotewold

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37. Jin, Z., Grotewold, E., Qu, W., Fu, G., and Zhao, D. (2005) Cloning and characterization of a

flavanone 3-hydroxylase gene from Saussurea medusa. DNA Sequence 16: 121-129.

38. Irani, N.G., and Grotewold, E. (2005) Light-induced morphological alteration in

anthocyanin-accumulating vacuoles of maize cells. BMC Plant Biology 5: 7.

39. Molina, C., and Grotewold, E. (2005) Genome-wide analysis of Arabidopsis core promoters.

BMC Genomics 6: 25.

40. Barg, R., Sobolev, I., Eilon, T., Gur, A., Chmelnitsky, I., Shabtai, S., Grotewold, E. and

Salts, Y. (2005) The tomato early fruit specific gene Lefsm1 defines a novel class of plant-

specific SANT/MYB domain proteins. Planta 221: 197-211.

41. Grotewold, E. (2005) Plant metabolic diversity: A regulatory perspective. Trends Plant Sci.

10: 57-62.

42. Hernandez, J., Heine, G., Irani, N.G., Feller, A., Kim, M.-G., Matulnik, T., Chandler, V.L.,

and Grotewold, E. (2004) Different mechanisms participate in the R-dependent activity of

the R2R3 MYB transcription factor C1. J. Biol. Chem. 279: 48205-48213.

43. Heine, G.F., Hernandez, J.M., and Grotewold, E. (2004) Two cysteines in plant R2R3 MYB

domains participate in REDOX-dependent DNA binding. J. Biol. Chem. 279: 37878-

37885.

44. Rangarajan, S., Raj, M.L.S., Hernandez, J.M., Grotewold, E., Gopalan, V. (2004) RnaseP as

a tool for disrupting gene expression in maize cells. Biochem. J. 380: 611-616.

45. Henry, I.M., Wilkinson, M.D., Hernandez, J.M., Schwarz-Sommer, Z., Grotewold, E., and

Mandoli, D.F. (2004) Comparison of ESTs from juvenile and adult phases of the giant

unicellular green alga Acetabularia acetabulum. BMC Plant Biology 4: 3.

46. Lin, Y., Irani, N.G., and Grotewold, E. (2003) Sub-cellular trafficking of phytochemicals

explored using auto-fluorescent compounds in maize cells. BMC Plant Biology 3: 10.

47. Davuluri, R.V., Sun, H., Palaniswamy, S.K., Matthews, N., Molina, C., Kurtz, M., and

Grotewold,

E. (2003) AGRIS: Arabidopsis Gene Regulatory Information Server, an

information resource of Arabidopsis cis-regulatory elements and transcription factors.

BMC Bioinformatics 4: 25 – 35.

48. Dias, A.P., Braun, E.L., McMullen, M.D., and Grotewold, E. (2003) Recently duplicated

maize R2R3 Myb genes provide evidence for distinct mechanisms of evolutionary

divergence after duplication. Plant Physiol. 131: 610-620.

49. Dias, A.P., and Grotewold, E. (2003) Manipulating the accumulation of phenolics in maize

cultured cells using transcription factors. Biochem. Engineering J. 14: 207-216.

50. Pooma, W., Gersos, C., and Grotewold, E. (2002) Transposon insertions in the promoter of

the Zea mays a1 gene differentially affect transcription by the Myb factors P and C1.

Genetics 161: 793-801.

51. Dong, X., Braun, E.L., and Grotewold, E. (2001) Functional conservation of plant secondary

metabolic enzymes revealed by complementation of Arabidopsis flavonoid mutants with

maize genes. Plant Physiol. 127: 46-57.

52. Braun, E.L., and Grotewold, E. (2001) Fungal Zuotin proteins evolved from MIDA1-like

factors by lineage-specific loss of MYB domains. Mol. Biol. & Evol. 18: 1401-1412.

Erich Grotewold

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53. Grotewold, E., Sainz, M.B., Tagliani, L., Hernandez, J.M., Bowen, B., and Chandler, V.L.

(2000) Identification of the residues in the Myb domain of C1 that provide the specificity

of the interaction with the bHLH cofactor R. Proc. Natl. Acad. Sci. USA 97: 13579-13584.

54. Rabinowicz, P.D., and Grotewold, E. (2000) A novel reverse-genetic approach (SIMF)

identifies Mutator insertions in new Myb genes. Planta 211: 887-893.

55. Braun, E.L., and Grotewold, E. (1999) Newly discovered plant c-myb-like genes rewrite the

evolution of the plant myb gene family. Plant Physiol. 121: 21-24.

56. Rabinowicz, P. D., E. L. Braun., A. D. Wolfe, B. Bowen, and E. Grotewold. (1999) Maize

R2R3 Myb genes: Sequence analysis reveals amplification in higher plants. Genetics 153:

427-444.

57. Grotewold, E., Chamberlain, M., St. Claire, G., Swenson, J., Siame, B.A., Butler, L.G.,

Snook, M. and Bowen, B. (1998) Engineering secondary metabolism in maize cells by

ectopic expression of transcription factors. Plant Cell 10: 721-740. (Featured in This

Issue commentary)

58. van Aalten, D.M.F., Grotewold, E. and Joshua-Tor, L. (1998) Essential dynamics from

NMR structures: dynamic properties of the Myb DNA-binding domain and a hinge-

bending enhancing variant. Methods - A companion to Methods in Enzymology. 14: 318-

328.

59. Sainz, M., Grotewold, E. and Chandler, V. (1997) Evidence for direct activation of an

anthocyanin promoter by the maize C1 protein and comparison of DNA-binding by

related Myb-domain proteins. Plant Cell. 9: 611-625.

60. Williams, C.E. and Grotewold, E. (1997) Differences between plant and animal Myb

domains are fundamental for DNA-binding activity and chimeric Myb domains have

novel DNA-binding specificities. J. Biol. Chem. 272: 563-571.

61. Rabinowicz, P.D., Roberts, C., and Grotewold, E. (1996). A gene encoding a putative

Mixta-homologous Myb-domain protein from Arabidopsis thaliana. Plant Physiol. 112:

863.

62. Grotewold, E., Drummond, B., Bowen, B. and Peterson, T. (1994). The Myb-homologous

gene controls phlobaphene pigmentation in maize floral organs by directly activating a

flavonoid biosynthetic gene subset. Cell 76: 543-553.

63. Grotewold, E. and Peterson, T. (1994). Isolation and characterization of a maize gene

encoding chalcone flavanone isomerase. Mol. Gen. Genet. 242: 1-8.

64. Athma, P., Grotewold, E. and Peterson, T. (1992). Insertional mutagenesis of the maize P

gene by intragenic transposition of Ac. Genetics 131: 199-209.

65. Grotewold, E., Athma, P. and Peterson, T. (1991). A possible hot spot for Ac insertion in the

maize P gene. Mol. Gen. Genet. 230: 329-331.

66. Grotewold, E., Athma, P. and Peterson, T. (1991). Alternatively spliced products of the

maize P gene encode proteins with homology to the DNA-binding domain of Myb-like

transcription factors. Proc. Natl. Acad. Science USA 88: 4587-4591.

67. Taccioli, G.E., Grotewold, E., Aisemberg, G.O. and Judewicz, N.D. (1991). The cDNA

sequence and expression of an ubiquitin-tail gene fusion in 102: 133-137.

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68. Grotewold, E., Aisemberg, G.O., Taccioli, G.E. and Judewicz, N.D. (1990). Genes

responsive to the alteration of polyamine biosynthesis in Neurospora crassa. Cell Biology

International Reports 14: 69-77.

69. Grotewold, E., Taccioli, G.E., Aisemberg, G.O. and Judewicz, N.D. (1989). Early response

and induced tolerance to cycoloheximide in Neurospora crassa. Current Genetics 15:

429-434.

70. Aisemberg, G.O., Grotewold, E., Taccioli, G.E. and Judewicz, N.D. (1989). A major

transcript in the response of Neurospora crassa to protein synthesis inhibition by

cycloheximide. Experimental Mycol. 13: 121-128.

71. Attar, R.M., Grotewold, E., Taccioli, G.E., Aisemberg, G.O., Torres, H.N. and Judewicz,

N.D. (1989). A cycloheximide inducible gene of Neurospora crassa belongs to the

cytochrome P-450 superfamily. Nucl. Acid Res. 17: 7535-7536.

72. Taccioli, G.E., Grotewold, E., Aisemberg, G.O. and Judewicz, N.D. (1989). Ubiquitin

expression in Neurospora crassa: cloning and sequencing of a polyubiquitin gene. Nucl.

Acid Res. 17: 6153-6164.

73. Grotewold, E., Taccioli, G.E., Aisemberg, G.O. and Judewicz, N.D. (1988). A single-step

purification of an exocellular fungal laccase. 4: 357-363.

74. Aisemberg, G.O., Taccioli, G.E., Grotewold, E. and Judewicz, N.D. (1987). Differential

gene expression promoted by cycloheximide in Neurospora crassa. Experimental Mycol.

11: 122-127.

REVIEWS (PEER REVIEWED)

75. Mejia-Guerra, M.K., Pomeranz, M., Morohashi, K., and Grotewold, E. (2012) From Plant

Gene Regulatory Grids to Network Dynamics. BBA - Gene Regulatory Mechanisms.

1819: 454-465.

76. Gray, J., Caparrós, D., and Grotewold, E. (2012). Grass phenylpropanoids: Regulate before

using! Plant Sci. 184: 112-120.

77. Brkljacic, J., Grotewold, E., Scholl, R., Mockler, T., Garvin, D.F., Vain, P., Brutnell, T.,

Sibout, R., Bevan, M., Budak, M., Caicedo, A.L., Gao, C., Gu, Y., Hazen, S.P., Holt III,

B.F., Hong, S.-Y., Jordan, M., Manzaneda, A.J., Mitchell-Olds, T., Mochida, K., Mur,

L.A.J., Park, C.-M., Sedbrook, J., Watt, M., Zheng, S.J., and Vogel, J.P. (2011)

Brachypodium as a model for the grasses: Today and the future. Plant Phyisiol. 157: 3-13.

78. Feller, A., Machemer, K., Braun, E.L., and Grotewold, E. (2011) Evolutionary and

comparative analysis of MYB and bHLH plant transcription factors. Plant J. 66: 94-116.

79. Dubos, C., Stracke, R., Grotewold, E., Weisshaar, B., Martin, C., and Lepiniec, L. (2010)

MYB transcription factors in Arabidopsis. Trends Plant Sci. 15: 573-581.

80. Grotewold, E. and Davies, K. (2008) Trafficking and sequestration of anthocyanins. Nat

Prod Comm. 3: 1251-1258.

81. Grotewold, E. (2008) Transcription factors for predictive plant metabolic engineering: Are

we there yet? Curr. Opin. Biotech. 19: 138-144.

82. Grotewold, E. (2006) The genetics and biochemistry of flower pigments. Ann. Rev. Plant

Biol. 57: 761-780.

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83. Taylor, L. P., and Grotewold, E. (2005) Flavonoids as developmental regulators Curr. Opin.

Plant Biol. 8: 317-323.

84. Grotewold, E. (2004) The challenges of moving chemicals within and out of cells: Insights

into the transport of plant natural products. Planta. 219: 906-909.

85. Walker, T.S., Bais, H.P., Grotewold,E. and Vivanco, J.M. (2003) Root exudation and

rhizosphere biology. Plant Physiol. 132: 44-51.

86. Mol, J., Grotewold, E., and Koes, R. (1998) How genes paint flowers and seeds. Trends

Plant Sci. 3: 212-217.

INVITED PUBLICATIONS, EDITORIALS, BOOK CHAPTERS AND REVIEWS

87. Chai, C., Xie, Z., and Grotewold, E. (2011) SELEX (Systematic Evolution of Ligands by

Exponential Enrichment), as a Powerful Tool for Deciphering the Protein-DNA

Interaction Space. Methods Mol Biol 754: 249-258.

88. Lichtenberg, J., Yilmaz, A., Kurz, K., Liang, X., Nelson, C., Bitterman, T., Stockinger, E.,

Grotewold, E., Welch, L.R. (2011) Encyclopedias of DNA elements for Plant Genomes.

In Advances in Genomic Sequence Analysis and Pattern Discovery. Elnitski, L.,

Piontkivska, H., Welch, L. (ed.). Hackensack, NJ: World Scientific Publishing Company

Volumen 7, pp. 159-178.

89. Knee, E.M., Rivero L., Crist, D., Grotewold, E., and Scholl, R. (2011) Germplasm and

molecular resources. In: I. Bancroft and R. Schmidt (eds) Genetics and Genomics of the

Brassicaceae. Plant Genetics and Genomics: Crops and Models. Springer, New York. pp

437-468.

90. Gray, J., and Grotewold, E. (2011) Transcription factors, gene regulatory networks and

agronomic traits. In Sustainable Agriculture and New Biotechnologies. N. Benkeblia

(ed.). CRC Press, Boca Rator, FL. Pp 65-94.

91. International Arabidopsis Informatics Consortium. (2010) An international bioinformatics

infrastructure to underpin the Arabidopsis community. Plant Cell, 22: 1-7.

92. Yilmaz, A. and Grotewold, E. (2010) Components and mechanisms of regulation of gene

expression. Methods Mol Biol, 674: 23-32.

93. Pourcel, L., and Grotewold, E. (2009) Phytochemicals, plant development and growth – Who

is in control? In Plant-Derived Natural Products: Synthesis, Function and Application.

Osbourn, A., and Lanzotti, V. (eds). Springer, New York, NY. Pp. 269-279.

94. Grotewold, E. and Gray, J. (2009) Maize transcription factors. In The Maize Handbook.

Hake, S. and Bennetzen, J. (ed). Springer, New York, NY. Vol 2 pp. 693 - 714.

95. Morohashi, K., Xie, Z., and Grotewold, E. (2009) Gene-specific and genome-wide ChIP

approaches to study plant transcriptional networks. Methods Mol Biol 553: 3-12.

96. Grotewold, E, and Springer, N. (2009) Decoding the transcriptional hardwiring of the plant

genome. In Annual Plant Reviews: Systems Biology. Coruzzi, G. and Gutierrez, R. (eds).

Blackwell Publishing. 35: 196-227.

97. Chappell, J. and Grotewold, E. (2008) Plant biotechnology -- predictive, green and

quantitative. Curr. Opin. Biotechnol. 19:129-130.

Erich Grotewold

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98. Quattrocchio, F., Baudry, A., Lepiniec, L., and Grotewold, E. (2006) The regulation of

flavonoid biosynthesis. In The Science of Flavonoids. Grotewold, E. (ed.) Springer, New

York, NY. pp. 97-122.

99. Wurtzel, E.T., and Grotewold, E. (2006) Plant Metabolic Engineering. In Encyclopedia of

Chemical Processing. Taylor & Francis, pp. 2191-2200

100. Onyilagha, J., and Grotewold, E. (2004) The biology and structural distribution of

surface flavonoids. Recent Res. Devel. Plant Sci. 2: 53-71

101. Pooma, W., and Grotewold, E. (2003) Transposons and the regulation of plant gene

expression. Adv. Plant Physiol. 6: 37-58.

102. Dias, A., Brown, J., Bonello, P., and Grotewold, E. (2003) Metabolite profiling as a

functional genomics tool. In Plant Functional Genomics: Methods & Protocols.

Grotewold, E. (ed) Humana Press , NJ. pp. 415-426.

103. Irani, N., Hernandez, J.M., and Grotewold, E. (2003) Regulation of anthocyanin

pigmentation. Recent Adv. Phytochem. 37: 59-78.

104. Grotewold, E. Subcellular trafficking of phytochemicals. (2001) Recent Res. Dev. Plant

Physiol. 2: 31-48.

105. Braun, E.L., Matulnik, T., Dias, A., and Grotewold, E. (2001) Transcription factors and

metabolic engineering: Novel applications for ancient tools. Recent. Adv. Phytochem. 35:

79-109.

PROCEEDINGS AND REPORTS

106. Grotewold, E., and Auer, H. (2010) The DNA-Proteome: Recent Advances Towards

Establishing the Protein-DNA Interaction Space. Intl. J. of Comp. Biosci. 1:1-3.

107. Yilmaz, A., Davuluri, R., Palaniswamy, S., and Grotewold, E. (2009) Discovery of

regulatory networks in plants by linking promoter and transcription factor databases.

Proceedings of the Ohio Collaborative Conference on Bioinformatics, IEEE Computer

Society Press, June 2009, pp. 61-64.

108. Lichtenberg, J., Alam, M., Bitterman, t., Drews, F., Ecker, K., Elnitski, L., Evans, S.,

Grotewold, E., Gu, G., Jacox, E., Kurz, K., Lee, S.S., Liang, X., Majmudar, P.M., Morris,

P., Nelson, C., Stockinger, E., Welch, J.D., Wyatt, S., Yilmaz, A., and Welch, L.R.

Construction of genomic regulatory encyclopedias: Strategies and case studies,”

Proceedings of the Ohio Collaborative Conference on Bioinformatics, IEEE Computer

Society Press, June 2009, pp. 65-70.

109. Smialek, J.L., Hernandez, J.M., and Grotewold, E. (2001). The C-terminal domain of the

maize p1 gene has a putative activation domain. Maize Genet. Coop. Newsl. 75: 18.

110. Lin, Y., Dong, X., and Grotewold, E. (2000). Preliminary analysis of green fluorescent

compounds induced by ectopic expression of the P gene. Maize Genet. Coop. Newsl. 74:

24-26.

111. Hernandez, J.M., Pizzirusso, M., and Grotewold, E. (2000). The maize MP1 gene encodes

a WD-protein similar to An11 and TTG. Maize Genet. Coop. Newsl. 74: 24.

112. Braun, E.L., and Grotewold, E. (1999). Diversification of the R2R3 Myb gene family and

the segmental allotetraploid origin of the maize genome. Maize Genet. Coop. Newsl. 73:

26-27.

Erich Grotewold

11

113. Grotewold, E. (1999). Ectopic expression of P and R+C1 induce few new proteins. Maize

Genet. Coop. Newsl. 73: 23-24.

114. Wang, H., and Grotewold, E. (1999). Aleurone and pericarp pigmentation in the a1-mum2

allele. Maize Genet. Coop. Newsl. 73: 24-25.

115. Rabinowicz, P.D., Ma, H., and Grotewold, E. (1997). Consequences of the ectopic

expression of the Myb-domain protein P. Maize Genet. Coop. Newsl. 71: 21-22.

116. Grotewold, E. (1995). Does P protein require a partner, as C1 protein does? Maize Genet.

Coop. Newsl. 69: 32.

117. Grotewold, E., Peterson, T., Drummond, B., Roth, B. and Bowen, B. (1992). Differential

regulation of flavonoid biosynthetic genes by the P gene. Maize Genet. Coop. Newsl. 66:

33-34.

118. Grotewold, E. and Peterson, T. (1991). Cloning of a P-regulated chalcone-flavanone

isomerase gene from maize. Maize Genet. Coop. Newsl. 65: 46-47.

119. Grotewold, E. and Peterson, T. (1990). Isolation of cDNA clones homologous to the P-

gene flanking regions. Maize Genet. Coop. Newsl. 64: 37.

BOOKS EDITED

Grotewold, E. (Editor) The Science of Flavonoids. (2006 & 2008) Springer, New York, NY.

Grotewold, E. (Editor) Plant Functional Genomics: Methods & Protocols. (2003) Humana Press,

Totowa, NJ.

PATENTS AND INVENTIONS

Transgenic plants with altered levels of phenolic compounds. Pat. No. 7,154,023.

Transgenic turfgrasses which signal exposure to chemicals and stress conditions. Pat. No.

6,709,867

Inhibition of monocyte survival, differentiation, or proliferation. Application No.

PCT/US06/020905

FEDERAL GRANT SUPPORT

Current

NSF IOS-1125620 PI: Grotewold, co-PI: Gray & Doseff 01/15/12 – 01/14/16

Title: Systems Approaches to Identify Gene Regulatory Networks in the Grasses

Total funding: $4,234,908

NSF MCB-1143813 PI: Grotewold, co-PI: Brkljacic 03/15/12 – 03/14/13

Title: Making the Arabidopsis Biological Resource Center Business Model Possible

Total Funding: $573,590

ASPB PI: Grotewold, co-PI: Brkljacic 08/15/11 – 10/31/12

Title: TRAINED - Translating Research on Arabidopsis Into a Network of EDucational

resources

Total Funding: $28,641

Erich Grotewold

12

NSF MCB-1062348 PI: Meyers, co-PI Grotewold (+3 others) 11/01/10 – 10/31/15

Title: RCN – An International Arabidopsis Informatics Consortium

Total funding: $499,373

NSF MCB-1048847 PI: Grotewold, co-PI: Otegui 03/01/11 – 02/28/14

Title: Trafficking and Sequestration of Anthocyanins


NSF DBI-0542034 PI: Grotewold, co-PI: Brkljacic 04/01/11 – 03/31/16

The Arabidopsis Biological Resource Center at the Ohio State University

Total funding: $ 1,843,728

USDA 2010-65115-20408 PI: Grotewold 11/01/09 – 10/31/12

Title: Regulation of anthocyanin biosynthesis


NSF PGRP-0701405 PI: Grotewold, co-PI: Gray 09/01/07 – 08/31/12

Title: Grass Regulome Initiative: Integrating control of gene expression and agronomic traits

across the grasses


Completed

BARD PI: Barg, co-PI Grotewold 09/01/07 – 08/31/11

Title: Regulation of tomato fruit development by interacting MYB proteins


DOE DE-FG02-07ER15881 PI: Grotewold 08/01/07 – 06/30/11

Title: Engineering phenolic metabolism in the grasses using transcription factors


NSF DBI-0542034 PI: Grotewold, co-PI: Scholl 05/01/06 – 03/31/11

The Arabidopsis Biological Resource Center at the Ohio State University

Total funding: $ 2,943,879

USDA-NRICGP 2007-01697 PI: Grotewold 09/01/07 – 08/31/10

Title: Transposons as gene control elements





NSF MCB-0705415 PI: Grotewold 03/01/07 – 02/28/09

Title: Development of CREMA: A high throughput method for the identification of promoter

mutations


Erich Grotewold

13

NSF MCB-0418891 PI: Grotewold, co-PI: Read, Davuluri, Lamb 09/01/04 – 08/31/08

Title: Establishing regulatory networks in Arabidopsis: Integrating AGRIS with the

Identification of direct targets for transcription factors


Ohio Plant Biotechnology Consortium PI: Grotewold 07/01/07 – 06/30/08

Title: Mutation enrichment: enhancing the opportunities for the identification of plant mutants


Ohio Plant Biotechnology Consortium PI: Gray, co-PI: Grotewold 07/01/07 – 06/30/09

Title: Identification of carbohydrate and phenolic metabolism regulatory genes in corn


OARDC PI: Francis, co-PIs: Schwartz & Grotewold 05/01/05 – 04/30/07

Tomato as a functional food: Metabolic engineering of carotenoid biosynthesis


NIH PI: Grotewold, co-PI: Chappell 04/07/07 – 12/31/07

Title: 2007 Gordon Research Conference Plant Metabolic Engineering


DOE PI: Grotewold, co-PI: Chappell 04/07/07 – 12/31/07

Title: 2007 Gordon Research Conference Plant Metabolic Engineering


NSF PI: Grotewold, co-PI: Chappell 04/07/07 – 12/31/07

Title: 2007 Gordon Research Conference and Graduate Seminar in Plant Metabolic Engineering

Total funding: $5,000)

Office of Naval Research PI: Grotewold, co-PI: Chappell 04/07/07 – 12/31/07

Title: 2007 Gordon Research Conference and Graduate Seminar in Plant Metabolic Engineering


NSF–MCB 0210413 PI: Grotewold 9/1/02 – 8/31/06

Title: Investigating promoter function in vivo and the role of transposons as control elements


USDA-NRICGP 2003-35318-13689 PI: Grotewold 10/01/03 – 09/30/06



NSF-MCB 0437318 PI: Grotewold 07/01/04 – 06/30/05

Title: Solid support-assisted screen of complex protein libraries with small molecules



Erich Grotewold

14

Title: Regulation of important agronomic traits by P


NSF-MCB-0130062 PI: Grotewold 2/1/02 – 1/31/05

Title: Organization of plant metabolic pathways and subcellular trafficking of phytochemicals


MCB-9974474 PI: Grotewold 9/1/99 - 8/31/02

Title: Dissecting promoter function in vivo


CPBR Inc./DOE PI: Gopalan, co-PI:Grotewold 1/1/01 - 12/31/02

Title: Ribozyme-mediated disruption of gene expression in plants


NSF-MCB-9896111 PI: Grotewold 10/1/97 - 6/01/01

Title: Regulatory specificity of the maize Myb-domain proteins P and C1


Pioneer Hi-Bred Intl PI: Grotewold 1/10/98 - 9/30/00

Title: Elucidation of the role of maize Myb-domain proteins


NSF-DBI-9970610 PI: Verma, co-PI: Grotewold 10/1/99 - 9/30/00

Title: Protein purification and detection system for plant biology


NSF-MCB-9406233 PI: Grotewold 11/1/94 -10/31/97

Title: Transcriptional regulation by P and C1, two maize Myb-homologs;


SCIENTIFIC ACTIVITIES

Program Reviewer

2012 Member Committee for the Evaluation of the Unidad de Biotecnología

Vegetal (UBV) at the Univesridad Javeriana, Bogotá, Colombia.

2010 Member Committee for the Evaluation of the Department of Biochemistry

at Purdue University, Purdue, IN.

Scientifc Publication Reviewer

2011 - Nature Chemical Biology

2011 - PLoS Genetics

2010 - Nature Review Genetics

2009 - Bioinformatics

2008 - Development

2008 - BMC Biotechnology

2008 - PLoS Biology

Erich Grotewold

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2008 - Sexual Plant Reproduction

2007 - Annals of Applied Biology

2007 - Genome Biology

2007 - Journal of Biological Chemistry

2006 - BMC Bioinformatics

2006 - Marine Biotechnology

2005 - BMC Plant Biology

2005 - Plant Biology

2005 - Physiologia Plantarum

2005 - BMC Evolutionary Biology

2005 - Molecular Biotechnology

2005 - Australian Journal of Agriculture

2004 - Journal of Biomedicine & Biotechnology

2004 - Electronic Journal of Biotechnology

2004 - Biochimica et Biophysica Acta

2004 - Journal of Experimental Botany

2004 - BMC Biology

2004 - Plant Biotechnology Journal

2004 - Biochemistry

2004 - Trends in Plant Science

2004 - Plant, Cell & Environment

2003 – Molecular Genetics & Genomics

2003 – Plant Functional Biology

2003 – Plant Science

2003 – Genome Research

2002 Eukaryotic Cell

2002 Biochemical Engineering Journal

2002 - Journal of Agricultural and Food Chemistry

2001 - Plant Science

2001 - Molecular and Cellular Biology

2001 - Nucleic Acids Research

2001 - Journal of Heredity

2000, 2009 Science

1999 - Proc. Natl. Acad. Sci. USA

1999 - Genetics

1999 - Molecular Plant-Microbe Interactions

1999 - Plant Journal

1998 - Genes & Development

1998 - Plant Physiology

1998 - Plant Molecular Biology

1998 - Biotechnology Progress

1997 - The Plant Cell

1997 - Gene

Grant Reviewer

Erich Grotewold

16

2012 Panel Member, Basic Research to Enable Agricultural Development

(BREAD) at the National Science Foundation

2011 Panel Member, Metabolism & Bacterial Communities Program at the

National Science Foundation

2011 Panel Member, FONCyT, Buenos Aires, Argentina

2009 Panel Member, Plant Genome Project at the National Science Foundation

2006 Ad hoc reviewer for GABI-FUTURE, German Federal Ministry of

Education and Research

2006 Ad hoc reviewer for Netherlands Organization for Scientific Research

2005 Panel Member, Functional Utilization of Plant Genomes US Dept. of

Agriculture-ARS

2005, 2002 Panel Member, Interagency Activity in Metabolic Engineering at the

National Science Foundation

2004 Panel Member, Plant Biochemistry at the US Dept. of Agriculture

2004 - Ad hoc reviewer for FONCyT, Ministerio de Educación, Ciencia y

Tecnología, Argentina

2003 Ad hoc reviewer for AAAS Research Competitiviness Service

2002 Panel Member, Eukaryotic Genetics at the National Science Foundation

2002 Ad hoc reviewer for the International Foundation for Sciences

2001 Ad hoc reviewer for the Ministry of Agriculture & Rural Development,

Israel

2000 - Ad hoc reviewer for the Consortium of Plant Biotechnology Research Inc.

grants

2000 - Ad hoc reviewer for US Dept. of Agriculture grants

1999, 2004, 2005 Panel Member, Biochemistry of Gene Expression Program at the National

Science Foundation

1997 - Ad hoc reviewer for National Science Foundation grants

Other

2010 Reviewer, Dept. Biochemistry, Purdue University, West Laffayette, IN

INVITED PRESENTATIONS

International

2012 “Systems Approaches to Unravel Plant Gene Regulatory Networks”. Universidad

Nacional. Bogotá, Colombia.


Javeriana. Bogotá, Colombia.


de los Andes. Bogotá, Colombia.

2011 “Combinatorial Control of Plant Gene Expression”. Volcani Center, Bet-Dagan,

Israel.

2011 “Systems Approaches to Unravel Regulatory Networks”. Weizmann Institute,

Rehovot, Israel.

2010 “Trafficking and Sequestration of Anthocyanins”. CEFOBI & University of

Rosario, Rosario, Argentina.

Erich Grotewold

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2010 “Plant Regulatory Networks and Development”. In SAIB 2010 (Argentine Society

of Biochemistry) Conference. Puerto Madryn, Argentina.

2010 “Trafficking and Sequestration of Anthocyanins”. In XXVth International

Conference on Polyphenols. Montpellier, France. (Plenary lecture)

2010 “The Arabidopsis Biological Resource Center”. RIKEN, Tsukuba, Japan.

2010 “The Arabidopsis Biological Resource Center”. In 21th

International Conference

on Arabidopsis Research, Yokohama, Japan.

2010 “From Gene Sequence to Systems Biology: The Emergence of Plant Model

Systems”. Tokyo University of Science, Tokyo, Japan.

2010 “Systems Approaches to Unravel Plant Regulatory Networks”. Fundacion Instituto

Leloir, Buenos Aires, Argentina.

2010 “Plant Regulatory Networks and Development”. CEFOBI & University of Rosario,

Rosario, Argentina.

2009 “From Gene Regulatory Networks to Plant Metabolic Engineering”. In Tripartite

Workshop of the Americas in Biotechnology and Bioenergy. University of São

Paulo, São Paulo, Brazil.

2009 “Systems Approaches to Unravel Plant Regulatory Networks”. RIKEN Center,

Yokohama, Japan.

2009 “Trafficking and Sequestration of Anthocyanins”. In 5th

International Workshop

on Anthocyanins”. Nagoya University, Nagoya, Japan. (Plenary Lecture)

2009 “Systems Approaches to Unravel Plant Regulatory Networks”. In The DNA

Proteome: Recent Advances Towards Establishing the Protein-DNA Interaction

Space. BBVA Foundation – IRB Barcelona, Spain.

2009 “Anthocyanins: From Regulation to Sequestration”. Centre de Recerca en

AgriGenomica (CRAG) – CSIS. Barcelona, Spain.

2008 "Combinatorial Control of Plant Gene Expression". University of São Paulo,

Brazil.

2008 "Establishing the Architecture of Regulatory Networks in Maize and Other

Grasses". In 54th

Congresso Brasileiro de Genética. Salvador de Bahia, Brazil.

2008 "Intriguing Aspects of Flavonoids and their Biosynthesis". In Plant Metabolism.

Banff, Canada.

2008 "Anthocyanins: From Regulation to Sequestration". Pleanary Talk in 19th

International Conference on Arabidopsis Research. Montreal, Canada.

2008 "Flavonoids: From Regulation to Sequestration". Interdisciplinary Studies in the

Chemical Biology of the Tropics. Explorer's Inn, Tambopata National Reserve,

Peru.

2008 "Combinatorial Control of Plant Gene Expression". Flanders Institute for

Biotechnology (VIB), Gent, Belgium.

2008 "A Regulatory Perspctive on Plant Metabolic Diversity". Institute for Plant

Biology, Halle, Germany.

2007 “Combinatorial Contral of Plant Gene Expression by MYB and bHLH Proteins”.

HortResearch, Auckland, New Zealand.

Erich Grotewold

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2007 “From Gene Sequences to Regulatory Netwroks”. In Queenstown Molecular

Biology Satellite Meeting on Gene Expression and Development. Quennstown,

New Zealand.

2007 “Combinatorial Control of Plant Gene Expression by MYB and bHLH Proteins”.

CEFOBI and University of Rosario, Rosario, Argentina.

2006 “Transcription Factors, Evolution and Metabolic Engineering: Beyond

Establishing Plant Regulatory Networks”. Miami University, Oxford, OH.

2006 “Combinatorial Conrol of Gene Expression by MYB and bHLH Transcription

Factors”. Colorado State University, Fort Collins, CO.

2006 “Establishing Plant Regulatory Networks”. Ohio University, Athens, OH.

2006 “Plant Regulatory Networks”. Nebraska Research Expo, Lincoln, NE.

2006 “Plant Transcription Factors and Metabolic Engineering”. U. Minnesota, Twin

Cities, MN.

2005 “Trafficking and Storage of Anthocyanins”. Suntory Ltd, Mishima, Japan.

2005 “Building Regulatory Networks in Arabidopsis: A Complex Puzzle with Too

Many Pieces”. In CREST-JST International Symposium 2005: Functional

Network of Transcription Factors in Plants. Tsukuba, Japan.

2004 “Regulation of Flavonoid Biosynthesis”. Free University Amsterdam, The

Netherlands.

2003 “Subcellular Trafficking of Phytochemicals”. In 5th

Symposium Mexico-USA,

Acapulco, Mexico.

2003 “Regulación de la Expresión Génica en Plantas” (Regulation of Plant Gene

Expression). INGEBI-University of Buenos Aires, Buenos Aires, Argentina.

2003 “Metabolic Engineering with Transcription Factors and Subcellular Trafficking of

Phytochemicals”. Lecture for Graduate Course in Plant Biotechnology, Faculty

of Pharmacy and Biochemistry, University of Buenos Aires, Argentina.

2003 “The Next Generation: Plant Metabolic Engineering with Transcription Factors”.

3rd

Biotechnology Workshop, Piracicaba, Brazil.

2002 “Regulatory Specificity of Myb Transcription Factors”. Brock University, St.

Catherine, Ontario, Canada.

2002 “Transcription Factors and Metabolic Diversity”. Phytochemical Society of

North America 2002 Conference, Mérida, Mexico.

2002 “Regulatory Specificty of R2R3 Myb Transcription Factors”. CSIRO, Canberra,

Australia.

2002 “Biosynthesis and Trafficking of Phytochemicals”. Univ. of Adelaide, Adelaide,

Australia.

2002 “Transcriptional Regulation of Flavonoid Biosynthetic Genes”. International

Workshop of Anthocyanins, Adelaide, Australia.

2001 “Regulation of Flavonoid Biosynthesis”. Symposium presentation at X Congreso

Nacional de Bioquímica y Biología Molecular de Plantas, La Paz, Mexico.

2000 “Evolution and Regulatory Specificity of Myb Transcription Factors”. Free

University Amsterdam, The Neatherlands

Erich Grotewold

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2000 “Transcription Factors and Plant Metabolic Engineering”. Plenary lecture at the

Fifth International Symposium on P450 Biodiversity, Elsinore, Denmark.

2000 “Regulatory Specificity of Plant Myb-Domain Proteins: Tools for Metabolic

Engineering?” Institut des Sciences Vegetales, CNRS, Gif-sur-Yvette, France.

1999 “Myb Proteins and Plant Diversity: Tools for Metabolic Engineering?” IX

Congreso Nacional de Bioquímica y Biología Molecular de Plantas, Mérida,

Mexico.

1996 “Regulation of Flavonoid Biosynthesis in Maize”. Free University Amsterdam,

The Neatherlands.

1996 “Transcriptional Regulation by Plant Myb-Domain Proteins”. Institut fuer

Allgemaine Botanik, University Hamburg, Germany.

1996 “Regulation of Transcription by Myb-Domain Proteins”. John Innes Centre,

Norwich, UK.

National

2012 “Systems Approaches to Unravel Plant Gene Regulatory Networks”. University of

Wisconsin-Madison, WI.

2012 “Systems Approaches to Unravel Plant Gene Regulatory Networks”. Institute of

Biological Chemistry, Washington State University, Pullman, WA.

2011 “From Plant Systems Biology to Renewable Fuels”. In FAPESP Week: 50 Years

of Science in Brazil and Challenges Ahead. Woodrow Wilson International Center

for Scholars. Washington DC.

2011 “Systems Approaches to Unravel Regulatory Networks”. State Univeristy of New

York at StonyBrook, NY.

2011 “Systems Approaches to Unravel Metabolic and Regulatory Networks”. University

of Northern Texas, Denton, TX.

2010 “Systems Approaches to Unravel Metabolic and Regulatory Networks”.

Brookhaven National Laboratory, Upton, NY.

2010 “Systems Approaches to Unravel Plant Regulatory Networks”. University of

Michigan, Ann Arbor, MI.

2010 “Plant Regulatory Networks and Development”. Plant Gene Expression

Center/Unv. California at Bereley, Albany, CA.

2010 “Plant Regulatory Networks and Development”. University of California at Davis,

Davis, CA.

2010 “Plant Regulatory Networks and Development”. North Carolina Biotechnology

Center, Research Triangle Park, NC.

2009 “Trafficking and Sequestration of Anthocyanins”. In Gordon Research Conference

in Plant Metabolic Engineering, Waterville, NH.

2008 "Combinatorial Control of Plant Gene Expression". University of Missouri-

Columbia, MI.

2007 “Phenolic Compounds in the Grasses: Regulation and Sequestration”. In Fifth

Tripartite Workshop in Biotechnology and BioEnergy, East Brunswick, NJ

Erich Grotewold

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2006 “Transcription Factors, Evolution and Metabolic Engineering: Beyond

Establishing Plant Regulatory Networks”. Miami University, Oxford, OH.

2006 “Combinatorial Control of Gene Expression by MYB and bHLH Transcription

Factors”. Colorado State University, Fort Collins, CO.

2006 “Establishing Plant Regulatory Networks”. Ohio University, Athens, OH.

2006 “Plant Regulatory Networks”. Nebraska Research Expo, Lincoln, NE.

2006 “Plant Transcription Factors and Metabolic Engineering”. U. Minnesota, Twin

Cities, MN.

2005 “Establishing Plant Regulatory Networks”. Michigan State University, East

Lansing, MI.

2005 “Control of Flavonoid Biosynthesis in Maize: A case for the Combinatorial

Control of Plant Gene Expression”. In Plant & Animal Genome XIII. San Diego,

CA.

2004 “Regulation of Flavonoid Biosynthesis: A Window Into the Combinatorial

Control of Plant Gene Expression”. University of Missouri-St. Louis, MO.

2004 “Regulatory Specificity of Plant MYB Transcription Factors”. Penn State

University, College Station, PA.

2003 “Regulatory Specificity of Plant MYB Transcription Factors”. Lehman College

of CUNY, New York, NY.

2003 “Regulation of Plant Gene Expression and Metabolic Engineering”. Ceres, Inc.

Malibu, CA.

2003 “Combinatorial Control of Plant Gene Expression”. Duke University, Durham,

NC.

2003 “Combinatorial Control of Plant Gene Expression”. Plant Gene Expression

Center/UC Berekely, Albany, CA.

2003 “Combinatorial Control of Plant Gene Expression”. UC Davis, Davis, CA.

2003 “Understanding Combinatorial Control of Plant Gene Expression”. Purdue

University, West Laffayette, IN.

2002 “Regulation of Plant Gene Expression”. California State University, San Marcos,

CA.

2002 “Regulatory Specificity of Plant Myb Domain Proteins”. DuPont, Wilmington,

Delaware.

2001 “Evolution of Novel Regulatory Functions in Plants”. Virginia Tech University,

Blacksburg, VA.

2001 “Engineering Plant Metabolism with Transcription Factors”. Pioneer Hi-Bred.

Intl., Johnston, IA.

2000 “Myb Transcription Factors and the Regulation of Plant Gene Expression”.

University of California at Davis, CA.

2000 “Myb Transcription Factors and the Regulation of Plant Gene Expression”.

Stanford University, CA.

2000 “Myb proteins and plant diversity: Tools for Metabolic Engineering?” University

of Kentucky, Lexington, KY.

Erich Grotewold

21

1999 “Regulation of Gene Expression by Plant Myb Proteins: New Tools for Old

Questions?” Institute of Biological Chemistry, Washington University, Pullman,

WA.

1999 “Regulatory Specificity, Function and Evolution of Plant Myb Proteins”. Univ. of

Illinois, Urbana, IL.

1999 “Myb proteins and plant diversity: Tools for Metabolic Engineering?” DuPont,

Wilmington, Delaware.

1999 "Evolution and Regulatory Specificity of Plant Myb-Domain Proteins". Iowa

State University, Ames, Iowa.

1999 “Myb Proteins and Plant Diversity: Tools for Metabolic Engineering?” Pioneer

Hi-Bred, Intl, Johnston, Iowa.

1999 “Plant Myb-Domain Proteins and Metabolic Diversity: Tools for Engineering

Secondary Metabolism?” First PBMB Symposium on Metabolic Networking in

Plants, Ames, IA.

1997 “Specificity and Biological Functions of Plant Myb-Domain Proteins”. Lehman

College, New York.

1997 “Plant Myb-Domain Proteins: Function and Biological Specificity”. Yale

University, New Haven, CT.

1996 “Myb Protein Function In Color”. Iowa State University, Ames, Iowa

1994 “Transcriptional Regulation by the Maize Myb-Homologs P and C1”. Gordon

Conference: Regulatory Mechanisms in Plants, New Hampton, NH.

1992 “Regulation of Transcription by the Maize Myb Gene”. Yale University, New

Haven, CT.

TEACHING ACTIVITIES

The Ohio State University

MG660 – Integrated Molecular & Cellular Biology for Non-Biologists (5 cr) – taught Autumn

2009 & Autumn 2010 (course co-developed by Erich Grotewold)

PCMB/MG 622 - Plant Molecular Biology (4 cr) – taught Winter quarters of 2000, 2001, 2002,

2003, 2004, 2005, 2006, 2007, 2009, 2010, 2011

PCMB 625 – Plant Metabolic Engineering (3 cr) – taught Spring quarter 2000 and Winter

quarters of 2001, 2003, 2009 (course developed by Erich Grotewold)

PCMB/HCS/PP 604.02 – Research Methods in Plant Science (4 cr) – taught Winter quarter 2004

ARTSCI 137 - Biotechnology & Society: What are the Issues Today? (1 cr) – taught Winter

quarters 2004 and 2007

Lecturer PCMB 736 - Plant Biochemistry (4/4/06)

Lecturer PP 703 – Agricultural Genomics (5/26/06)

Cold Spring Harbor Laboratory

Molecular Techniques in Plant Science - Lecturer and Instructor (7/8/07; 7/5/08; 7/5-6/09)

Documents

ERICH GROTEWOLD, Ph · P., and Grotewold. (2012) A genome-wide regulatory framework identifies maize ... L.* (2012) A regulatory switch enforced by bHLH and ACT domain-mediated dimerizations