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Epigenetics in disease and well-being
“Trans-generational disease vulnerability: does epigenesis explain it all?”
Linköping University, January 20-21, 2016
Many diseases and dysfunctions of non-microbiological origin have substantially increased over
the past 40-50 years. Common to many of these is the metabolic syndrome (MS) a series of metabolic risk
factors that increase the predisposition of an individual to atherosclerotic vascular disease, hypertension
and type-2 diabetes. Alongside there is increasing evidence that environmental factors, including exposure
to pharmaceutical and toxic chemicals, diet or stress, pre-conception, intra-utero or even post-natal are
able to modify the expression of genes and lead to dysfunction. However, this modification is run through
positive or negative modifications in the epigenome (e.g. the complex of modifications associated with
genomic DNA, which imparts a unique cellular and developmental identity, without leading to mutations).
Such epigenetic modifications can have lasting effects on development, metabolism and health even at
later age, evidencing profound alterations of the epigenetic profile of an individual, animal or human, that
could well be passed over generations. On the other hand, if a phenotype is caused by epigenetic
modifications (as DNA-methylation, histone modifications of the action of non-codingRNAs) some of
these pathways could be chemically reversed. The latter opens for the development of eventual
therapeutics of epigenesis, to modulate/reverse unfavorable processes.
This research education seminar intends to gather researchers working in different aspects of
comparative epigenetics, from basic research to epidemiological, animal and human cohort studies,
bridging animal models with clinical human medicine. The goal is to provide a broad spectrum of research
and current knowledge on trans-generational effects for graduate students, junior researchers and
clinicians stimulating future research projects and the improvement of personalized medicine.
Programme
Day 1 (20) Registration opens Get-together (light lunch) Programme starts - Moderator: Prof Heriberto Rodriguez-Martinez, IKE, Linköping University Introduction to JSPS and SAC: Dr Hideo Akutsu, Director JSPS Stockholm office; Ma Li Svensson, SAC-Chair Feast, Famine and Fatness - A fly model of paternally induced obesity, Dr Anita Öst, IKE, Linköping University, Sweden ([email protected]) Perinatal nutritional status alters anxiety- and depression- like behaviors in the offspring: evidence for trans-generational effects mediated via epigenetic mechanisms, Dr Annika Thorsell,
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IKE, Linköping University, Sweden ([email protected]) Trans-generational epigenetic effects of stress on animal welfare, Prof Per Jensen, IFM-Biology, Linköping University, Sweden ([email protected]) Epigenetic alterations induced by environmental stresses associated with metabolic and neurodevelopmental disorders, Prof Takeo Kubota, Yamanashi University, Japan ([email protected]) 17.00- Discussion seminars Day 2 (21) Premature birth and low birth-weight – consequences for reproduction in adulthood: a Swedish population-based registry study, Prof Gunilla Sydsjö, University Hospital, Linköping ([email protected]) ”Stress in five-year-old children is associated with hypo-methylation across the human genome” Dr D Nätt, IKE. Linköping University, Sweden ([email protected]) “Cause, consequence or cure; dissecting the function and therapeutic potential of DNA methylation in complex immune disease”, Dr Colm Nestor, Centre for Individualized Medicine, LiU, Sweden ([email protected]) “Early psychosocial exposures increase infant HPA axis activity and risk of common childhood diseases - a prospective cohort study “, Dr Jerker Karlén, IMH, Linköping University, Sweden ([email protected]) ICSI is more often used when assisting infertile men born small for gestational age; why?, Dr Susanne Liffner, University Hospital, Linköping - ([email protected] “Trans-generational and epigenetic effects of endocrine disruptors”, Dr Carlos Guerrero-Bosagna, IFM-Biology, Linköping University, Sweden ([email protected]) “The developmental origins of chronic physical aggression: biological pathways triggered by early life adversity”, Dr Nadine Provencal, Max-Planck Institute of Psychiatry, Germany ([email protected]) Discussion seminars Concluding ceremony: Ma Li Svensson, SAC-Chair & Prof Mats Hammar (IKE/County Univ Hospital)
