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Epidemiology of HIV Among Pediatric* Cases in Florida, through 2011 HIV/AIDS and Hepatitis Program Data as of 07/31/2012 *Infected prior to age 13 Created: 07/31/12 Revision:

Epidemiology of HIV Among Pediatric* Cases in Florida, through 2011 HIV/AIDS and Hepatitis Program Data as of 07/31/2012 *Infected prior to age 13 Created:

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Page 1: Epidemiology of HIV Among Pediatric* Cases in Florida, through 2011 HIV/AIDS and Hepatitis Program Data as of 07/31/2012 *Infected prior to age 13 Created:

Epidemiology of HIV Among Pediatric* Cases

in Florida, through 2011

HIV/AIDS and Hepatitis ProgramData as of 07/31/2012*Infected prior to age 13

Created: 07/31/12

Revision: 12/11/12

Page 2: Epidemiology of HIV Among Pediatric* Cases in Florida, through 2011 HIV/AIDS and Hepatitis Program Data as of 07/31/2012 *Infected prior to age 13 Created:

Pediatric HIV Surveillance

Pediatric HIV cases include those persons who were infected with HIV UNDER 13 years of age.

Pediatric AIDS cases include those pediatric HIV cases that have developed AIDS, regardless of age of AIDS diagnosis.

The first pediatric AIDS case was born in 1979, diagnosed in 1982 and reported in 1983.

HIV (not AIDS) reporting began 07/1997.

Page 3: Epidemiology of HIV Among Pediatric* Cases in Florida, through 2011 HIV/AIDS and Hepatitis Program Data as of 07/31/2012 *Infected prior to age 13 Created:

Pediatric HIV SurveillanceLimitations

Limitations: Due to reporting lags, the most recent

calendar year data are considered to be provisional.

HIV/AIDS Surveillance data are always being updated as newly diagnosed pediatric cases are identified, even if years later.

Page 4: Epidemiology of HIV Among Pediatric* Cases in Florida, through 2011 HIV/AIDS and Hepatitis Program Data as of 07/31/2012 *Infected prior to age 13 Created:

Acronyms

ART = Antiretroviral TherapyAZT = Antiretroviral Zidovudine TherapyIDU = Injecting Drug UseNIR = No Identified Risk

Page 5: Epidemiology of HIV Among Pediatric* Cases in Florida, through 2011 HIV/AIDS and Hepatitis Program Data as of 07/31/2012 *Infected prior to age 13 Created:

Pediatric AIDS Cases by Age Group at Diagnosisand Year of Diagnosis, 1990-2011, Florida

These data represent an 90% decline in pediatric AIDS cases by year of diagnosis 1992 (N=178) to 2011 (N=17). Due to reporting lags, 2011 data by year of diagnosis are provisional. Data as of 12/31/2011

0

20

40

60

80

100

120

90 91 92 93 94 95 96 97 98 99 00 01 02 03 04 05 06 07 08 09 10 11

Year of Diagnosis

Nu

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ases

Aged <2 years at AIDS diagnosis

Aged >=2 years at AIDS diagnosisN=1,500

Page 6: Epidemiology of HIV Among Pediatric* Cases in Florida, through 2011 HIV/AIDS and Hepatitis Program Data as of 07/31/2012 *Infected prior to age 13 Created:

Pediatric AIDS Cases, By Age Group and Year of Diagnosis, 1990-2011, Florida

0

10

20

30

40

50

60

70

80

90

90 91 92 93 94 95 96 97 98 99 00 01 02 03 04 05 06 07 08 09 10 11

Year of Diagnosis

Nu

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ases

<1 yrs 1-5 yrs 6-12 yrs 13+ yrs

Age Group

As time goes on, the pediatric HIV case are more likely to NOT develop AIDS until after age 12.

N=1,501

Page 7: Epidemiology of HIV Among Pediatric* Cases in Florida, through 2011 HIV/AIDS and Hepatitis Program Data as of 07/31/2012 *Infected prior to age 13 Created:

0

20

40

60

80

100

120

90 91 92 93 94 95 96 97 98 99 00 01 02 03 04 05 06 07 08 09 10 11

Year of Diagnosis

Pe

rce

nt

of

Ca

se

s

<1 yrs 1-5 yrs 6-12 yrs 13+ yrs

Age Group

The number of perinatally infected persons aging to adolescence and adulthood before being diagnosed with AIDS is increasing gradually. This may be an indication of successful treatment and care.

Pediatric AIDS Cases, by Age Group and Year of Diagnosis, 1990-2011, Florida

N=1,501

Page 8: Epidemiology of HIV Among Pediatric* Cases in Florida, through 2011 HIV/AIDS and Hepatitis Program Data as of 07/31/2012 *Infected prior to age 13 Created:

Cumulative Pediatric AIDS CasesReported 1983 through 2011, By County, Florida

Statewide data:N=1,860Number of Cases

0

1 - 10

11 - 25

26 - 50

over 50

Note: The first pediatric AIDS case was reported in 1983.Data as of 07/31/2012

Page 9: Epidemiology of HIV Among Pediatric* Cases in Florida, through 2011 HIV/AIDS and Hepatitis Program Data as of 07/31/2012 *Infected prior to age 13 Created:

Cumulative Pediatric HIV (not AIDS) CasesReported 07/1997 through 12/2011, By County, Florida

Statewide data:N=649

Note: HIV (not AIDS) reporting began 07/1997.Data as of 07/31/2012

Number of Cases

0

1 - 10

11 - 20

over 20

Page 10: Epidemiology of HIV Among Pediatric* Cases in Florida, through 2011 HIV/AIDS and Hepatitis Program Data as of 07/31/2012 *Infected prior to age 13 Created:

Cumulative Pediatric AIDS Cases Reported For Selected States, Reported through 2010*

Reporting State # of Cases % of TotalNew York 2,437 25%Florida 1,570 16%New Jersey 811 8%California 703 7%Texas 398 4%Pennsylvania 378 4%Maryland 338 3%Illinois 290 3%Georgia 252 3%Massachusetts 231 2%Connecticut 188 2%Virginia 188 2%District of Columbia 190 2%Remaining States 1,924 19%

Total Cases 9,898 100% Source: Cumulative Data from CDC, HIV/AIDS Surveillance Report, 2010 Table 20

*Remainder of Area includes the remaining states

Note: National 2010 data not yet available.

Page 11: Epidemiology of HIV Among Pediatric* Cases in Florida, through 2011 HIV/AIDS and Hepatitis Program Data as of 07/31/2012 *Infected prior to age 13 Created:

10%

74%

14%

1% White

Black

Hispanic

Other

44%20%

29% 7%

Pediatric HIV/AIDS Cases N=2,520 Population Estimates

N= 2,841,831

Note: Non-Hispanic blacks are disproportionately affected by HIV/AIDS compared with those of other race/ethnicities. This same trend is seen in adult HIV/AIDS cases but is more pronounced in those diagnosed with HIV Disease under 13 years of age. *The first pediatric AIDS case was reported in 1983.**Source: Population estimates are provided by Florida CHARTS

Pediatric* HIV/AIDS Cases and State Population** in Children <13 years of age, by Race/Ethnicity,

Reported* through 2011, Florida

Page 12: Epidemiology of HIV Among Pediatric* Cases in Florida, through 2011 HIV/AIDS and Hepatitis Program Data as of 07/31/2012 *Infected prior to age 13 Created:

Cumulative Pediatric (<13 yr.) HIV/AIDS Cases by Mode of Exposure

United States*(AIDS cases reported through 2010)

(N=9,475)

Florida (reported through 2011)

(N=2,509)

Other Pediatric

Risk**9%

Perinatally Acquired

91%

*US data include estimated AIDS cases from the US and DC. 2011 data not yet available.**Other Pediatric Risk includes receipt of blood products or unknown risk.

Other Pediatric

Risk**5%

Perinatally Acquired

95% N=2,389N=8,640

Page 13: Epidemiology of HIV Among Pediatric* Cases in Florida, through 2011 HIV/AIDS and Hepatitis Program Data as of 07/31/2012 *Infected prior to age 13 Created:

Cumulative Pediatric HIV/AIDS Cases, by “Expanded” Modes of Exposure,

Reported through 2011, Florida

22%

11%

2%

34%

25%1%

1%2%

<1%1%

1%

22% Mom-Injection Drug User

11% Mom-Sex w/ Injection Drug User

2% Mom-sex w/ Male Sex with Male

34% Mom-sex w/ person w/ HIV/AIDS

1% Mom-Blood Recipient

<1% Mom-sex w/ blood recipient

25% Mom-HIV/AIDS, Risk Unknown

2% Ped-Hemophilia*

1% Ped-Transfus/Transplant*

1% Ped-Confirmed Other*

1% Ped-No Identified Risk*

*Note: 5% (exploded pieces) are NOT perinatal transmission cases

N=2,509

Page 14: Epidemiology of HIV Among Pediatric* Cases in Florida, through 2011 HIV/AIDS and Hepatitis Program Data as of 07/31/2012 *Infected prior to age 13 Created:

Prevalence of AIDS-Defining Conditions* Most Commonly Reported among Pediatric Cases

Reported through 2011, FloridaAIDS Defining Condition # Cases % Cases

Pneumocystis pneumonia 489 26%

Bacterial infections 432 23%

Candidiasis, esophageal 407 22%

Wasting syndrome 371 20%

Lymphoid interstitial pneumonia 301 16%

HIV encephalopathy 256 14%

Cytomegalovirus disease 145 8%

Herpes simplex 117 6%

Candidiasis, bronchi or lungs 84 5%

Cryptosporidiosis 81 4%

No Disease (Immune suppressed only)** 229 12%

Total Cases 1,861

Note: Of the 2,509 HIV/AIDS pediatric cases, 1,861 (74%) have developed AIDS. *Data are NOT mutually exclusive, many cases have more than one disease.**Immune suppressed: CD4 count <200ul or CD4 percent <14%.

Page 15: Epidemiology of HIV Among Pediatric* Cases in Florida, through 2011 HIV/AIDS and Hepatitis Program Data as of 07/31/2012 *Infected prior to age 13 Created:

Perinatal Acquired HIV Infected Cases

Page 16: Epidemiology of HIV Among Pediatric* Cases in Florida, through 2011 HIV/AIDS and Hepatitis Program Data as of 07/31/2012 *Infected prior to age 13 Created:
Page 17: Epidemiology of HIV Among Pediatric* Cases in Florida, through 2011 HIV/AIDS and Hepatitis Program Data as of 07/31/2012 *Infected prior to age 13 Created:
Page 18: Epidemiology of HIV Among Pediatric* Cases in Florida, through 2011 HIV/AIDS and Hepatitis Program Data as of 07/31/2012 *Infected prior to age 13 Created:
Page 19: Epidemiology of HIV Among Pediatric* Cases in Florida, through 2011 HIV/AIDS and Hepatitis Program Data as of 07/31/2012 *Infected prior to age 13 Created:

0

20

40

60

80

100

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79 81 83 85 87 89 91 93 95 97 99 01 03 05 07 09 11

Year of Birth

Nu

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ases

Perinatally Acquired HIV Infected Cases,Born in Florida, by Year of Birth, 1979-2011

Birth # % change

2001 372002 20 -46%2003 20 0%2004 13 -35%2005 14 8%2006 19 36%2007 17 -11%2008 11 -35%2009 9 -18%2010 6 -33%2011 3 -50%

Note: These data represent a 97% decline in HIV-perinatally infected births from 1993 (N=110) to 2011 (N=3)Includes ALL perinatally acquired HIV Infection cases BORN in Florida.2011 data are provisional. Data as of 03/31/2012

N=1,185

Page 20: Epidemiology of HIV Among Pediatric* Cases in Florida, through 2011 HIV/AIDS and Hepatitis Program Data as of 07/31/2012 *Infected prior to age 13 Created:

0102030405060708090

100

93 94 95 96 97 98 99 00 01 02 03 04 05 06 07 08 09 10 11

Year of Report

Nu

mb

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ases

Black

HispanicWhite

Note: The majority of the perinatally acquired HIV Infection cases born in Florida are black. They represent greater than 70% of the cases for most years. Data for other/mixed race/ethnicity groups (N=19) not shown.

Perinatally Acquired HIV Infection Cases,Born in Florida, by Race/Ethnicity

and Year of Birth, 1979-2011

N=1,193

Page 21: Epidemiology of HIV Among Pediatric* Cases in Florida, through 2011 HIV/AIDS and Hepatitis Program Data as of 07/31/2012 *Infected prior to age 13 Created:

0

10

20

30

40

50

60

70

80

79 81 83 85 87 89 91 93 95 97 99 01 03 05 07 09 11

Year of Birth

Nu

mb

er

of

Ca

se

s

Heterosexual Contact Mother's Risk not Specified Injection drug use Transfusion

Note: From 1990, the risk of Injection drug use decreased as the risk of heterosexual contact continued to increase.

Perinatally Acquired HIV Infection CasesBorn in Florida, by Mother’s Mode of Exposure

and Year of Birth, 1979-2011

N=1,193

Page 22: Epidemiology of HIV Among Pediatric* Cases in Florida, through 2011 HIV/AIDS and Hepatitis Program Data as of 07/31/2012 *Infected prior to age 13 Created:

58%

27%

0%

15%

Mother's risknot specified

Heterosexualcontact

Injection druguse

Transfusion

15%

1%

67%

17%

Born 1979-1993N =626

Born 1994-2011N =567

Perinatally Acquired HIV Infection CasesBorn in Florida, by Mother’s Mode of Exposure

and Year of Birth, 1979-2011

Note: among children who were infected perinatally with HIV/AIDS, the distribution of their mothers’ exposure categories has changed over time. For both time periods, heterosexual contact was the highest risk, with 58% of the cases born 1979-1993, increasing to 67% of cases born 1994-2011.

N=1,193

Page 23: Epidemiology of HIV Among Pediatric* Cases in Florida, through 2011 HIV/AIDS and Hepatitis Program Data as of 07/31/2012 *Infected prior to age 13 Created:

8%

81%

9%

1%White

Black

Hispanic

Other 47%

21%

28%4%

Perinatally Acquired HIV Infection Cases

N=1,193

Population EstimatesN= 2,950,829

Perinatally Acquired HIV Infection CasesBorn in Florida, and State Population*

by Race/Ethnicity, Born through 2011, Florida

Note: Perinatally acquired HIV infection cases among non-Hispanic blacks are disproportionately affected compared with those of other race/ethnicities. *Source: Population estimates are provided by FloridaCHARTS

Page 24: Epidemiology of HIV Among Pediatric* Cases in Florida, through 2011 HIV/AIDS and Hepatitis Program Data as of 07/31/2012 *Infected prior to age 13 Created:

020406080

100120140160180200

0-5 6-11 12-17

18-23

2 3 4 5 6 7 8 9 10 11 12 13

Nu

mb

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ases

Age in Months Age in Years

Nearly one half (49%, N=187) of the 380 perinatal HIV (not AIDS) cases born through 2011 were diagnosed less than the first 6 months of life. Two-thirds (66%, N=253) of these perinatal HIV cases were diagnosed under the age of two. Furthermore, 2 (1%) were diagnosed with a perinatal risk after the age of 12.

< 2 yrs of age

Perinatally Acquired HIV (not AIDS) CasesBorn in Florida 1979-2011

By Age at HIV Diagnosis (N=380)

Page 25: Epidemiology of HIV Among Pediatric* Cases in Florida, through 2011 HIV/AIDS and Hepatitis Program Data as of 07/31/2012 *Infected prior to age 13 Created:

0

50

100

150

200

250

0-5 6-11

12-17

18-23

2 3 4 5 6 7 8 9 10 11 12 13* 14* 15* 16* 17* 18* 19* 20+

Nu

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ases

Age in Months

Age in Years

< 2 yrs of age

More than one half (59%) (N=477) of the perinatal AIDS cases born through 2011 (N=813), were diagnosed with AIDS prior to the age of two. The number of AIDS cases diagnosed after age two decreases by age. Twelve percent (N=95) of the cumulative AIDS cases were not diagnosed with AIDS until after the age of twelve (up from 5% in 2003).

Perinatally Acquired AIDS CasesBorn in Florida 1979-2011

By Age at AIDS Diagnosis, (N=813)

Page 26: Epidemiology of HIV Among Pediatric* Cases in Florida, through 2011 HIV/AIDS and Hepatitis Program Data as of 07/31/2012 *Infected prior to age 13 Created:

AIDS-Defining Conditions for Perinatally Acquired AIDS Cases Less than Two Years of Age

Born in Florida 1979-2011By Age at AIDS Diagnosis (N=477)

0

10

20

30

40

50

0 2 4 6 8 10 12 14 16 18 20 22

Age in Months

Nu

mb

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ases Pneumocystis pneumonia

Other AIDS definingconditions

The peak of PCP in children with perinatally acquired AIDS is four months of age. The age at diagnosis for the other AIDS-defining conditions is much more evenly distributed during the first two years of life.

Page 27: Epidemiology of HIV Among Pediatric* Cases in Florida, through 2011 HIV/AIDS and Hepatitis Program Data as of 07/31/2012 *Infected prior to age 13 Created:

Note: These data represent a 100% decline in HIV-perinatally infected births from 1992 (N=95) to 2011 (N=0). 2011 data are provisional. Data as of 07/31/2012.

0

20

40

60

80

90 91 92 93 94 95 96 97 98 99 00 01 02 03 04 05 06 07 08 09 10 11

Year of Birth

Nu

mb

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f C

ases

<2 yrs.

>=2 yrs.

Age Group

Perinatally Acquired AIDS CasesBorn in Florida 1990-2011

By Age Group and Year of Birth (N=620)

Page 28: Epidemiology of HIV Among Pediatric* Cases in Florida, through 2011 HIV/AIDS and Hepatitis Program Data as of 07/31/2012 *Infected prior to age 13 Created:

Living Perinatally Acquired HIV Infection CasesBy County of Birth, Born in Florida 1979 through 2011

N=821

Number of Cases

0

1 - 10

11 - 25

26 - 50

over 50

Florida has 821 living Perinatally Acquired HIV Infection cases born 1979 through 2011, with the majority (57%) of these cases born in South Florida: Miami-Dade (N=234), Broward (N=134) and Palm Beach (N=100). Data as of 07/31/2012

Page 29: Epidemiology of HIV Among Pediatric* Cases in Florida, through 2011 HIV/AIDS and Hepatitis Program Data as of 07/31/2012 *Infected prior to age 13 Created:

0

20

40

60

80

0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31

Current Age

Nu

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ases

HIV (not AIDS) AIDS

Current Age* Distribution OfLiving Perinatally Acquired HIV Infection Cases

By Disease Status, Born in Florida 1979 through 2011 (N=821)

*Current age of living (not known dead) HIV/AIDS perinatal cases born through 2011.Data as of 07/31/2012

Page 30: Epidemiology of HIV Among Pediatric* Cases in Florida, through 2011 HIV/AIDS and Hepatitis Program Data as of 07/31/2012 *Infected prior to age 13 Created:

Region of Birth # of cases % of TotalArea 01* 2 3%Area 03* 1 1%Area 08 (Lee Only) 3 4%Area 08 (not Lee)* 0 0%Area 15* 4 5%Broward County 15 19%Duval County 9 11%Hillsborough/Pinellas Counties 5 6%Miami-Dade County 17 22%Orange County 10 13%Palm Beach County 5 6%Polk 2 3%Remainder of state 6 8%TOTAL CASES 79 100%*Area 1 = Escambia, Okaloosa, Santa Rosa & Walton Counties;

*Area 3 = Alachua, Bradford, Columbia, Dixie, Gilchrist, Hamilton, Lafayette, Levy, Putnam, Suw annee, & Union Counties;

* Area 8 (not Lee) = Charlotte, Collier, DeSoto, Glades, Hendry & Sarasota Counties.

*Area 15 = St. Lucie, Indian River, Martin, and Okeechobee Counties.

Born 2005-2011

*A total of 4 perinatal cases reported in Florida were born outside of the US and NOT included in these data.

Perinatally Acquired HIV Infection CasesBy Selected Regions of Birth

Born in Florida 2005 through 2011

Page 31: Epidemiology of HIV Among Pediatric* Cases in Florida, through 2011 HIV/AIDS and Hepatitis Program Data as of 07/31/2012 *Infected prior to age 13 Created:

74%

8%

10%

8% 0-5 months

6-12 months

1 year

2+ years

62%

12%

13% 13%

HIV (not AIDS) Cases (N=71) AIDS Cases (N=8)

Perinatally Acquired HIV Infection CasesBorn in Florida 2005-2011

By Disease Status and Age Group (N=79)

Note: Eighty-two percent (82%) of the HIV (not AIDS) cases perinatally infected and born in Florida 2005-2011 were diagnosed with HIV within the first year of life. Ten percent (N=8) have been diagnosed and reported with AIDS. Eight-seven percent of these cases (N=7) developed AIDS within the first year of life.

Page 32: Epidemiology of HIV Among Pediatric* Cases in Florida, through 2011 HIV/AIDS and Hepatitis Program Data as of 07/31/2012 *Infected prior to age 13 Created:

Time of Maternal HIV Testingamong Perinatally Acquired HIV Infection Cases

Born in Florida, 2005-2011 (N=79)

Note: Two-thirds (N=49 ,66%) of the 78 HIV-infected mom’s who gave birth in Florida between 2005 & 2011 knew they were infected before delivery. It is important for HIV-infected pregnant women to know their HIV infection status in order to make informed decisions about antiretroviral therapy to reduce perinatal transmission of HIV to their infants. The Public Health Service recommends that all pregnant women be offered HIV counseling and voluntary HIV tests.

48%

18%

10%

23%

1%Before Pregnancy (N=37)

During Pregnancy (N=14)

At Delivery ( N=8)

After Birth (N=18)

Unknown ( N=1)

Page 33: Epidemiology of HIV Among Pediatric* Cases in Florida, through 2011 HIV/AIDS and Hepatitis Program Data as of 07/31/2012 *Infected prior to age 13 Created:

Women Giving Birth to Perinatally Acquired HIV Positive Babies in FloridaBy Mother’s Knowledge of HIV Status at Delivery

By Year of Birth 2005-2011

0%

20%

40%

60%

80%

100%

2005 2006 2007 2008 2009 2010 2011

Before Delivery After Delivery

Note: The proportion of pregnant women giving birth to a child diagnosed with HIV and who knew their HIV status prior to delivery varies from year to year, ranging from 53 to 90%.

Page 34: Epidemiology of HIV Among Pediatric* Cases in Florida, through 2011 HIV/AIDS and Hepatitis Program Data as of 07/31/2012 *Infected prior to age 13 Created:

Possible Missed Opportunities that Could Have PreventedPerinatal Transmission of HIV among HIV Positive Babies

Born in Florida, 2005-2011

Total Born Florida, 2005-2011 79

Missed Opportunities Number PercentMom's HIV Status NOT Known Before Birth 19 24%Inadequate Prenatal Care* 55 70%No Prenatal Antiretroviral Therapy 48 61%No Antiretroviral Therapy at Delivery 34 43%Non-Caesarean Birth 34 43%No Neonatal Antiretroviral Therapy 18 23%Breast Fed 7 9%Other Contributing Factors** Number PercentMom was a substance abuser 25 32%Mom acquired an STD 26 33%*Inadequate prenatal care indicates prenatal care after the 4th month and less than 5 visits

**The same child can be in multiple categories

Page 35: Epidemiology of HIV Among Pediatric* Cases in Florida, through 2011 HIV/AIDS and Hepatitis Program Data as of 07/31/2012 *Infected prior to age 13 Created:

Perinatally Acquired HIV Infection Cases in ChildrenWhose Mom’s HIV status was Known Prior to Delivery

Born in Florida 2005-2011By Receipt of Adequate Prenatal Care and

Any Prenatal Antiretroviral Therapy (ART) (N=52)

Adequate Prenatal CareBegan by 4th month with 5+ visits

Any Prenatal ARTAZT and/or antiretrovirals

Yes No

31%

69%

58%

42%

Page 36: Epidemiology of HIV Among Pediatric* Cases in Florida, through 2011 HIV/AIDS and Hepatitis Program Data as of 07/31/2012 *Infected prior to age 13 Created:

Elective CaesareanDelivery

Yes No

38%

62%

ART During LaborAZT and/or antiretrovirals

79%

21%

Perinatally Acquired HIV Infection Cases in ChildrenWhose Mom’s HIV status was Known Prior to Delivery

Born in Florida 2005-2011By Receipt of Antiretroviral Therapy (ART) During Delivery

And Elective Caesarean Delivery (N=52)

Page 37: Epidemiology of HIV Among Pediatric* Cases in Florida, through 2011 HIV/AIDS and Hepatitis Program Data as of 07/31/2012 *Infected prior to age 13 Created:

Maternal Drug AbuseHistory of an STDDuring Pregnancy

Yes35%

No65%

Note: A total of 9 (11%) of the mothers had BOTH abused drugs and had an STD during pregnancy.

Yes32%

No68%

Perinatally Acquired HIV Infection Cases in ChildrenBorn in Florida 2005-2011

By Maternal Drug Abuse andHistory of a Sexually Transmitted Disease (STD) (N=79)

Page 38: Epidemiology of HIV Among Pediatric* Cases in Florida, through 2011 HIV/AIDS and Hepatitis Program Data as of 07/31/2012 *Infected prior to age 13 Created:

Received any Neonatal ART Breastfed

No23%

Yes77%

Yes9%

No/Unkn91%

Perinatally Acquired HIV Infection Cases in ChildrenBorn in Florida 2005-2011

By Receipt of Neonatal Antiretroviral Therapy (ART)And Exposure to Breastfeeding (N=79)

Page 39: Epidemiology of HIV Among Pediatric* Cases in Florida, through 2011 HIV/AIDS and Hepatitis Program Data as of 07/31/2012 *Infected prior to age 13 Created:

Perinatally Acquired HIV Infection CasesBorn in Selected South Florida Counties 2005-2011

By Mother’s Exposure Category (N=37)

12%

82%

6%

Mom IDU Mom-Sex Risk Mom’s Risk-Other/Unkn.

93%

7%

40%

60%

Miami-Dade (N=17) Broward (N=15) Palm Beach (N=5)

Note: A total of 37 (47% of the state total) perinatally acquired HIV Infection cases born in Florida 2005-2011were born in Miami-Dade, Broward and Palm Beach counties. There is some variation in the Mother’s exposure category by county.

Page 40: Epidemiology of HIV Among Pediatric* Cases in Florida, through 2011 HIV/AIDS and Hepatitis Program Data as of 07/31/2012 *Infected prior to age 13 Created:

82%

12%6%

<1 year 1 year 2+ years

87%

0% 13%

100%

0%0%

Perinatally Acquired HIV Infection CasesBorn in Selected South Florida Counties 2005-2011

By Age at First Diagnosis (N=37)

Note: Eighty percent (32 of 37) of the perinatally acquired HIV Infection cases born in South Florida were diagnosed within the first year of life. As noted earlier, an early diagnosis of perinatally acquired HIV infection allows the opportunity of early treatment, thus possibly prolonging the onset of AIDS.

Miami-Dade (N=17) Broward (N=15) Palm Beach (N=5)

Page 41: Epidemiology of HIV Among Pediatric* Cases in Florida, through 2011 HIV/AIDS and Hepatitis Program Data as of 07/31/2012 *Infected prior to age 13 Created:

86%

7%

7%

82%

18%

White Black Hispanic Other/Unknown

Note: pediatric AIDS in Florida disproportionately affects non-Hispanic blacks. In South Florida, 81%,

(30 of 37) of the pediatric HIV/AIDS cases were among blacks. These data differ greatly from

the population by race/ethnicity for women of childbearing age (15-44) living in these counties.

Miami-Dade (N=17) Broward (N=15) Palm Beach (N=5)

60%

20%

20%

Perinatally Acquired HIV Infection CasesBorn in Selected South Florida Counties 2005-2011

By Race/Ethnicity (N=37)

Page 42: Epidemiology of HIV Among Pediatric* Cases in Florida, through 2011 HIV/AIDS and Hepatitis Program Data as of 07/31/2012 *Infected prior to age 13 Created:

HIV Status for Babies BornTo an HIV-Infected Mother in Florida

2007-2011

99.4%

0.6%

Exposed Only

HIV-Infected

# % # % # % # % # %Infected 17 2.5% 11 1.8% 9 1.4% 6 1.1% 3 0.6%Not Infected 655 97.5% 617 98.2% 612 98.6% 563 98.9% 522 99.4%Total Births 672 628 621 569 525

201120102007 2008 2009

2011 Births

A total of 525 babies were known to be born to HIV-Infected mothers in Florida in 2011, of which 3 (0.6%) were known to be HIV-infected. (Data as of 07/31/2012)Note: Perintal Exposure became reportable 11/20/2006, 2007 is the first complete year.

Page 43: Epidemiology of HIV Among Pediatric* Cases in Florida, through 2011 HIV/AIDS and Hepatitis Program Data as of 07/31/2012 *Infected prior to age 13 Created:

STEPS TO PERINATAL SUCCESS

Get an HIV TestGet Prenatal Care If HIV+, MaintainMedication Adherence

Keep All Prenatal Appointments

Follow Up for MomAnd Baby

Ensure Baby Gets6-weeks of AZT

Page 44: Epidemiology of HIV Among Pediatric* Cases in Florida, through 2011 HIV/AIDS and Hepatitis Program Data as of 07/31/2012 *Infected prior to age 13 Created:

STEPS TO PERINATAL SUCCESS, CONTINUED

Link to Birth Control if thatIs the Client’s Choice

Ensure that BabyReceives HIV testing By 4 months

Counsel Against Breast Feeding

Page 45: Epidemiology of HIV Among Pediatric* Cases in Florida, through 2011 HIV/AIDS and Hepatitis Program Data as of 07/31/2012 *Infected prior to age 13 Created:

Perinatal Programs

• Perinatal Prevention is focused on:

– Prevention Services for women of child bearing age.

– Ensuring services for HIV-infected pregnant women and their newborns

– Education and technical assistance for clinicians who treat pregnant women.

Page 46: Epidemiology of HIV Among Pediatric* Cases in Florida, through 2011 HIV/AIDS and Hepatitis Program Data as of 07/31/2012 *Infected prior to age 13 Created:

The Targeted Outreach for Pregnant Women Act (TOPWA) program.

Collaboration with state agencies and organizations to ensure that perinatal HIV issues are addressed.

Perinatal social marketing campaign on Face Book and Twitter

The Perinatal HIV Program” is located on the HIV/AIDS and Hepatitis Program internet site

A Perinatal website through USF that is widely used

Provide 6-weeks of free AZT for newborns of families with no medical coverage

Page 47: Epidemiology of HIV Among Pediatric* Cases in Florida, through 2011 HIV/AIDS and Hepatitis Program Data as of 07/31/2012 *Infected prior to age 13 Created:

The Baby RxPress Program provides a voucher that can be exchanged at Walgreens for the six-weeks of AZT that is prescribed for all HIV-exposed newborns.

Vouchers can be obtained from a local HIV perinatal nurse or the HIV/AIDS and Hepatitis Program Prevention Section.

Page 48: Epidemiology of HIV Among Pediatric* Cases in Florida, through 2011 HIV/AIDS and Hepatitis Program Data as of 07/31/2012 *Infected prior to age 13 Created:

AETC staff work to:• educate medical professionals who provide care for

HIV-infected pregnant women and their babies.• Assist hospitals in implementing rapid HIV testing in

labor & delivery units.• Maintain a comprehensive website with CDC

guidelines, forms, and resources for clinicians

http://www.usfcenter.org/Perinatal/

Page 49: Epidemiology of HIV Among Pediatric* Cases in Florida, through 2011 HIV/AIDS and Hepatitis Program Data as of 07/31/2012 *Infected prior to age 13 Created:

8 programs (3 also have jail components)

Conducts outreach to high-risk pregnant women and actively links them with services

Offers on-site pregnancy and HIV testing.

Assists mothers with obtaining family planning services if they choose to delay the birth of a subsequent baby

Page 50: Epidemiology of HIV Among Pediatric* Cases in Florida, through 2011 HIV/AIDS and Hepatitis Program Data as of 07/31/2012 *Infected prior to age 13 Created:

HIV-Infected Newborns 2007-2012HIV-Infected Newborns 2007-2012

MADISON

TAYLOR

JEFFERSON

SANTA ROSAOKALOOSA

WALTON

HOLMES

JACKSON

WASHINGTON

CALHOUNBAY

GULF

GADSDEN

LIBERTY

FRANKLIN

LEON

WAKULLA

HAMILTON

SUWANNEE

LAFAYETTE

DIXIE

COLUMBIA

GILCHRIST

LEVY

ALACHUAPUTNAM

MARION

LAKECITRUS

SUMTER

HERNANDO

BAKER

NASSAU

DUVAL

CLAYST JOHNS

FLAGLER

VOLUSIA

SEMINOLE

ORANGEBREVARD

OSCEOLA

PASCO

HILLSBOROUGHPOLK

MANATEEHARDEE

HIGHLANDS

PINELLAS

UNION

INDIAN RIVER

OKEECHOBEEST LUCIE

MARTIN

PALM BEACH

BROWARD

DADEMONROE

COLLIER

HENDRYLEE

CHARLOTTE GLADES

DESOTOSARASOTA

ESCAMBIA

2007 Births

Updated 7/31/12

(17)

(12) 2008 Births

2009 Births(9)

(6) 2010 Births

2011 Births

+

(3)

2012 Births(2)

Page 51: Epidemiology of HIV Among Pediatric* Cases in Florida, through 2011 HIV/AIDS and Hepatitis Program Data as of 07/31/2012 *Infected prior to age 13 Created:

MADISON

TAYLOR

JEFFERSON

ESCAMBIA

SANTA ROSAOKALOOSA

WALTON

HOLMES

JACKSON

WASHINGTON

CALHOUN

BAY

GULF

GADSDEN

LIBERTY

FRANKLIN

LEON

WAKULLA

HAMILTON

SUWANNEE

LAFAYETTE

DIXIE

CO

LU

MB

IA

GILCHRIST

LEVY

BRADFORD

ALACHUA

PUTNAM

MARION

LAKECITRUS

SUMTER

HERNANDO

BAKER

NASSAU

DUVAL

CLAY ST JOHNS

FLAGLER

VOLUSIA

SEMINOLE

ORANGEBREVARD

OSCEOLA

PASCO

HILLSBOROUGHPOLK

MANATEE

HARDEE

HIGHLANDS

PINELLAS

UNION

INDIAN RIVER

OKEECHOBEE

ST LUCIE

MARTIN

PALM BEACH

BROWARD

DADEMONROE

COLLIER

HENDRYLEE

CHARLOTTEGLADES

DESOTOSARASOTA

3

2

6

89

2

8

1

399

1

2

1

1

2

452

3

3

15

16

73

116

2

2

35

6

54

4

15 10

2

3

2

13

9

1

1

2011HIV-Exposed/InfectedBabiesExposed: 552Infected: 3

Updated 10/1/12

11

5

7

1

1

3

1

11

Page 52: Epidemiology of HIV Among Pediatric* Cases in Florida, through 2011 HIV/AIDS and Hepatitis Program Data as of 07/31/2012 *Infected prior to age 13 Created:

HIV-Infected Newborns 2007-2012HIV-Infected Newborns 2007-2012

MADISON

TAYLOR

JEFFERSON

SANTA ROSAOKALOOSA

WALTON

HOLMES

JACKSON

WASHINGTON

CALHOUNBAY

GULF

GADSDEN

LIBERTY

FRANKLIN

LEON

WAKULLA

HAMILTON

SUWANNEE

LAFAYETTE

DIXIE

COLUMBIA

GILCHRIST

LEVY

ALACHUAPUTNAM

MARION

LAKECITRUS

SUMTER

HERNANDO

BAKER

NASSAU

DUVAL

CLAYST JOHNS

FLAGLER

VOLUSIA

SEMINOLE

ORANGEBREVARD

OSCEOLA

PASCO

HILLSBOROUGHPOLK

MANATEEHARDEE

HIGHLANDS

PINELLAS

UNION

INDIAN RIVER

OKEECHOBEEST LUCIE

MARTIN

PALM BEACH

BROWARD

DADEMONROE

COLLIER

HENDRYLEE

CHARLOTTE GLADES

DESOTOSARASOTA

ESCAMBIA

2007 Births

Updated 7/31/12

(17)

(12) 2008 Births

2009 Births(9)

(6) 2010 Births

2011 Births

+

(3)

2012 Births(2)

Page 53: Epidemiology of HIV Among Pediatric* Cases in Florida, through 2011 HIV/AIDS and Hepatitis Program Data as of 07/31/2012 *Infected prior to age 13 Created:

Region of Birth # of cases % of TotalArea 01* 2 3%Area 03* 1 1%Area 08 (Lee Only) 2 3%Area 08 (not Lee)* 0 0%Area 15* 4 5%Broward County 15 20%Duval County 8 11%Hillsborough/Pinellas Counties 3 4%Miami-Dade County 16 22%Orange County 9 12%Palm Beach County 6 8%Polk 2 3%Remander of state 6 8%TOTAL CASES 74 100%*Area 1 = Escambia, Okaloosa, Santa Rosa & Walton Counties;

*Area 3 = Alachua, Bradford, Columbia, Dixie, Gilchrist, Hamilton, Lafayette, Levy, Putnam, Suw annee, & Union Counties;

* Area 8 (not Lee) = Charlotte, Collier, DeSoto, Glades, Hendry & Sarasota Counties.

*Area 15 = St. Lucie, Indian River, Martin, and Okeechobee Counties.

Born 2005-2010

22%7%

2%

55%

13%

Screened(N =197,893)

Enrolled(N =36,955)

Proportion of Women Screened and Enrolled in TOPWA by Race/Ethnicity

~January 1999 – December 2011~

Page 54: Epidemiology of HIV Among Pediatric* Cases in Florida, through 2011 HIV/AIDS and Hepatitis Program Data as of 07/31/2012 *Infected prior to age 13 Created:

Proportion of Women Screened and Enrolled in TOPWA by Age

~January 1999 – December 2011~

47%

2%

3%

13%

34%

1%

<15

15-24

25-34

35-44

45 +

Missing

33%

8%

1%

58%

1%

0%

Screened(N =197,893)

Enrolled(N =36,955)

Page 55: Epidemiology of HIV Among Pediatric* Cases in Florida, through 2011 HIV/AIDS and Hepatitis Program Data as of 07/31/2012 *Infected prior to age 13 Created:

Prenatal HIV Testing among Women Delivering a Live Birth, Florida, 1996-2007

65

70

75

80

85

90

95

100

96 97 98 99 00 01 02 03 04 05 07

Year

Per

cen

t T

este

d

= 95% C.I.

Note: Florida’s percentage of childbearing women tested perinatally for HIV is the highest in the U.S., which has probably contributed to the continued decline in pediatric HIV/AIDS cases. Source: Florida Pregnancy Risk Assessment Monitoring System (PRAMS),(2006 or 2008 not available, 2007 had half of normal sample size).http://www.doh.state.fl.us/disease_ctrl/epi/Chronic_Disease/PRAMS/Data_Books.htm

Page 56: Epidemiology of HIV Among Pediatric* Cases in Florida, through 2011 HIV/AIDS and Hepatitis Program Data as of 07/31/2012 *Infected prior to age 13 Created:

HIV Seroprevalence among Childbearing Women by Survey Cycle and Mother’s Race

Florida, 1988-1995

0

5

10

15

20

1988 1989 1990 1992 1992 1993 1994 1995

Survey Cycle

Rat

e p

er 1

,000

White

Black

Total

*Number Positive/Number Tested x 1,000.Survey Cycles are October through March, except for the last cycle which was 10/95-12/95.This survey ended in 1995.

Page 57: Epidemiology of HIV Among Pediatric* Cases in Florida, through 2011 HIV/AIDS and Hepatitis Program Data as of 07/31/2012 *Infected prior to age 13 Created:

Cases of HIV Disease among Women of Childbearing Age (Ages 15-44),

by Age of Diagnosis, and Year of Diagnosis, 2002–2011, Florida

0

100

200

300

400

500

600

700

800

900

2002 2003 2004 2005 2006 2007 2008 2009 2010 2011Year of Diagnosis

Nu

mb

er o

f C

ases

15-24 25-29 30-39 40-44

Decreases in newly diagnosis HIV/AIDS cases among women ages 15-44 have been observed by all age groups.

Page 58: Epidemiology of HIV Among Pediatric* Cases in Florida, through 2011 HIV/AIDS and Hepatitis Program Data as of 07/31/2012 *Infected prior to age 13 Created:

0

200

400

600

800

1,000

1,200

1,400

1,600

1,800

2002 2003 2004 2005 2006 2007 2008 2009 2010 2011

Year of Diagnosis

Nu

mb

er

of

Ca

se

sCases of HIV Disease among

Women of Childbearing Age (Ages 15-44), by Mode of Exposure,

and Year of Diagnosis, 2002–2011, Florida

Heterosexual

IDU

Note: NIRs redistributed.

Page 59: Epidemiology of HIV Among Pediatric* Cases in Florida, through 2011 HIV/AIDS and Hepatitis Program Data as of 07/31/2012 *Infected prior to age 13 Created:

Cases of HIV Disease among Women of Childbearing Age (Ages 15-44),

by Race/Ethnicity, and Year of Diagnosis, 2002–2011, Florida

0

200

400

600

800

1,000

1,200

1,400

2002 2003 2004 2005 2006 2007 2008 2009 2010 2011

Year of Diagnosis

Nu

mb

er o

f C

ases

Black

Hispanic

White

Note: Although the majority of HIV cases among women are black, the percent of black female HIV cases has decreased from 74% in 2002 to 69% in 2011. Increases have been observed among both white and Hispanic female HIV cases over this same time period. *Other races represent less than 1% of the cases and are not included. Data as of 05/16/12

Page 60: Epidemiology of HIV Among Pediatric* Cases in Florida, through 2011 HIV/AIDS and Hepatitis Program Data as of 07/31/2012 *Infected prior to age 13 Created:

Annual Prevalence of HIV Disease, among Women of Childbearing Age (Ages 15-44),

By Race/Ethnicity, Reported 1995-2011, Florida

0

2,000

4,000

6,000

8,000

10,000

12,000

95 96 97 98 99 00 01 02 03 04 05 06 07 08 09 10 11

Year of Diagnosis

Nu

mb

er

of

Cases

White Black Hispanic

Page 61: Epidemiology of HIV Among Pediatric* Cases in Florida, through 2011 HIV/AIDS and Hepatitis Program Data as of 07/31/2012 *Infected prior to age 13 Created:

For Florida HIV/AIDS Surveillance Data Contact: (850) 245-4444

Lorene Maddox, MPH Ext. 2613 Tracina Bush, BSW Ext. 2612 Julia Fitz, MPH Ext. 2373

Visit Florida’s internet site for:•Monthly Surveillance Reports•Slide Sets and Fact Sheets•Annual Reports and Epi Profiles http://www.doh.state.fl.us/disease_ctrl/aids/trends/trends.html

Visit CDC’s HIV/AIDS Internet site for:Surveillance Reports, fact sheets and slide sets http://www.cdc.gov/hiv/topics/surveillance/resources/reports/index.htm