EP-147: A dult-Derived Mesenchymal Stem Cells and Stromal Vascular Fraction from Adipose Tissue as a...
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EP-147: A dult-Derived Mesenchymal Stem Cells and Stromal Vascular Fraction from Adipose Tissue as a Therapeutic Treatment for Osteoarthritis H. Mahmood,
EP-147: A dult-Derived Mesenchymal Stem Cells and Stromal
Vascular Fraction from Adipose Tissue as a Therapeutic Treatment
for Osteoarthritis H. Mahmood, N. Smith, J. Feller, M. Berman, E.
Lander, J. Braslow, J. See, K. Abeyratne, C. Hancock
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Disclosure Statement This presentation does not depict any
activity regarding financial interest or other relationships (i.e.,
grants, research support, consultant, speakers bureau, major stock
holder, etc) with the manufacturer(s) of any commercial product(s),
(drugs, devices, or services) and with any commercial supporters of
the activity.
1908 The term stem cell was proposed by the histologist
Alexander Maksimov 1978 Haematopoietic stem cells are discovered in
human cord blood 1981 "Embryonic Stem Cell described in mice 1992
Neural stem cells are cultured in-vitro as neurospheres 2003 Adult
stem cells found in childrens primary teeth 2005 UC Irvine
partially restores the ability of rats with paralyzed spines to
walk through the injection of human neural stem cells History of
Stem Cells Harper, Alicia. "Stem Cell Therapy." Global
Hydranencephaly Foundation. 2013 Global Hydranencephaly Foundation,
n.d. Web. 21 Apr. 2014.
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Stem Cells A History October 2006: Scientists in England create
the first ever artificial liver cells using umbilical cord blood
stem cells. March 2008: Cartilage regeneration in the human knee
using autologous adult mesenchymal stem cells. 30 October 2008:
Embryonic-like stem cells from a single human hair. January 2009:
Reversal of autoimmune-caused type 1 diabetes by Cord Blood Derived
Multipotent Stem Cells in an animal experiment. 2011: Stem cells
from endangered species, a breakthrough that could save animals in
danger of extinction. 2013: First time mice adult cells were
reprogrammed into stem cells in vivo. 2013: 3D printer that can
produce clusters of living human ESCs,.
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Disk Regeneration 15 Guinea Pigs Disk Lanced Levels Randomized
Spine (Phila Pa 1976). 2011 Mar 15;36(6):E373-9. Autologous stem
cell therapy maintains vertebral blood flow and contrast diffusion
through the endplate in experimental intervertebral disc
degeneration. Bendtsen M 1, Bnger CE, Zou X, Foldager C, Jrgensen
HS
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T2 Mapping
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JBJS January -2014 55 Patients Partial medial menisectomy Three
Groups - Randomized 50 Million Stem Cells 150 Million Stem Cells
Control Hyaluronate (Hyaluronic Acid/ hyaluronan) C. Thomas
Vangsness, Jr. MD. Et al. Adult Human Mesenchymal Stem Cells (MSC)
Delivered via IntraArticular Injection to the Knee, Following
Partial Medial Menisectomy, Journal of Bone and Joint Surgery,
January 2014
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JBJS 2014 Stem Cell - Conclusions No Abnormal (ectopic) tissue
formation No Clinically Important Safety Issues Identified
Significant Increase in Meniscal Volume in Test group and none in
Control group Osteoarthritis patients Reduction in Pain in Test
group and none in Control group AAOS - Stem Cell Therapy Following
Meniscus Knee Surgery May Reduce Pain, Restore Meniscus
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Patient Safety First Concern IRB Approved Study Patient - Study
Enrollment Determine Target Site Suppress Fat Signal Osseous Edema
Capsulitis Pericapsulitis
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T2 Prolongation Suppress Fat Signal Osseous Edema Capsulitis
Pericapsulitis STIR or T2 FSInflamed Facets
Benefits of Image Guidance to Perform Therapeutic Stem Cell
Injections: Accurate targeting of pain generator Accurate delivery
to target Objective evidence of response to therapy CT Guidance:
80% Improvement Fluoroscopy: 50% Improvement Blind Injection: 30%
Improvement ASSR Spine Injection Background
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Materials: CT Image Guidance
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Cervicalgia Facet Joint Pain Determine Inflamed Facet Joint/s
T2 Fat Sat, STIR, or T1 Fat Sat Post contrast
Summary Conclusion: Image Guidance SVF & Stem Cell Therapy
I.Determine Target. II.Delivery of Stem cells & SVF to the
target. III.Follow up response to therapy. IV.Positive Therapeutic
Experience Observed V.Propose further Research Thank you!
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