Enzyme Sources Guide final - · PDF fileThe!Enzyme!Sources!Guide!includes!profiles!of!244!companies!that!are!developers,!manufacturers!or! suppliers!of!enzymes;

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Sustainable!Chemistry!Solutions,!Inc.:!http://www.bio:catalyst.com!! 1!!

Enzyme'Sources'Guide'

Published'by'Sustainable'Chemistry'Solutions,'Inc.'

2014'Edition'

For'regular'updates'on'the'enzyme'industry'sent'directly'to'your'inBbox,'subscribe'to'the'Mainstream'

Biocatalysis'Newsletter:'http://www.bioBcatalyst.com'

Enzyme'industry'information'and'news'you'can'use'

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Introduction'

The!enzyme!market!is!growing!and!changing.!Enzymes!and!biocatalysts!have!become!increasingly!important!in!a!an!ever:broadening!range!of!applications!that!include!chemicals,!pharmaceuticals,!food!and!feed,!textiles,!pulp!and!paper,!brewing!and!winemaking,!diagnostics!and!analytics,!molecular!biology,!detergents,!baking,!and!more.!Some!of!these!applications!have!been!long!served!by!well:known!enzymes,!but!recent!rapid!advances!in!protein!engineering!and!expression!techniques!have!greatly!expanded!the!scope!and!usefulness!of!enzymes!in!many!other!contexts.!Particularly!in!chemical!processing,!enzymes!can!be!engineered!to!fit!process!conditions!using!laboratory!evolution!techniques,!allowing!biocatalysts!to!replace!chemical!alternatives!in!an!increasingly!wider!range!of!processes.!These!recent!advances!have!resulted!in!a!growing!number!of!companies,!both!large!and!small,!that!provide!enzymes!and!enzyme!technology.!!!

New!suppliers!and!developers!of!enzymes!are!entering!the!market,!and!existing!enzyme!companies!are!expanding!their!offerings!and!capabilities.!Smaller!companies!are!being!acquired!by!larger!ones!(BASF!‘s!acquisition!of!Verenium!or!Novozymes’!acquisition!of!Allopartis!are!two!recent!examples),!and!large!companies!are!merging!to!create!even!larger!companies!(for!example:!Genencor:Danisco:DuPont).!

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Keeping!abreast!of!the!changes!in!the!enzyme!market!is!challenging,!and!knowing!which!company!offers!competitive!products!in!the!varied!and!changing!competitive!landscape!is!even!tougher.!!

Did!you!know!that!there!are!more!than!240!developers!and!sellers!of!enzymes!around!the!world?!!How!do!you!know!which!suppliers!to!trust,!which!enzyme!developers!can!best!meet!your!needs?!How!do!you!contact!them?!Are!you!interested!in!contact!manufacturing!or!custom!enzyme!development?!How!do!navigate!such!a!rapidly!developing!and!evolving!marketplace?!!

The!Enzyme!Sources!Guide!helps!you!answer!all!these!questions!and!more.!The!information!contained!in!the!Guide!will!inform!you!about!the!players!in!the!enzyme!industry!and!facilitate!the!search!for!an!enzyme!provider!or!technology!provider!or!partner!that!meets!your!needs.!!!

The!Enzyme!Sources!Guide!includes!profiles!of!244!companies!that!are!developers,!manufacturers!or!suppliers!of!enzymes;!these!companies!span!the!range!from!large!established!multi:national!corporations!with!many!enzyme!offerings!to!small!start:up!companies!providing!a!handful!of!enzymes!in!relatively!small!amounts.!!The!guide!is!comprehensive!and!covers!enzyme!companies!worldwide.!!The!selection!criteria!for!company!inclusion!required!that!a!company!is!a!seller!or!developer!of!enzyme!products!or!a!provider!enzyme!research!or!manufacturing!services.!Developers!and!suppliers!of!enzymes!for!industrial,!animal!feed,!food!and!beverage!processing!are!included,!along!with!suppliers!of!enzymes!for!biocatalysis,!research,!diagnostics,!and!life!sciences!applications.!

Looking!for!a!commercially:stable!supplier!of!lipases?!The!Enzyme!Sources!Guide!lists!suppliers!from!around!the!world!and!tells!you!the!size!of!the!company!and!how!long!that!company!has!been!in!business.!

Need!a!conveniently!located!supplier!of!a!range!of!different!enzymes!for!biocatalysis?!The!Enzyme!Sources!Guide!shows!you!all!the!suppliers!of!enzymes!for!biocatalysis!and!their!product!lines,!listed!by!geographical!region,!so!that!you!can!find!the!most!convenient!provider,!no!matter!where!your!business!is!located.!

Interested!in!identifying!a!contract!research!partner?!The!Enzyme!Sources!Guide!tells!you!which!enzyme!developers!also!offer!contract!research!services.!

Need!to!find!a!contract!manufacturer!for!an!enzyme?!The!Enzyme!Sources!Guide!has!a!listing!of!contract!manufacturers!for!enzymes!around!the!world.!The!Enzymes!Sources!Guide!also!contains!profiles!of!all!the!companies!so!that!you!can!more!quickly!identify!the!best!supplier!for!your!enzyme!needs.!

Looking!for!immobilized!enzymes?!A!comprehensive!list!of!companies!supplying!immobilized!enzymes,!support!materials,!and!immobilization!technology!is!included.!

The!Enzyme!Sources!Guide!will!give!you!actionable!information!on!enzyme!suppliers!around!the!world!so!that!you!will!save!time!in!sourcing!enzymes!and!biocatalysis!partners.!

The!Enzyme!Sources!Guide!is!the!only!comprehensive!listing!of!more!than!200!enzyme!suppliers!around!the!world!so!that!you!can!identify!all!options!for!enzyme!supply,!not!just!a!few.!

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The!Enzyme!Sources!Guide!breaks!down!enzyme!suppliers!around!the!world!so!that!you!can!easily!locate!the!supplier!nearest!your!location,!most!convenient!!

The!Enzyme!Sources!Guide!breaks!down!enzyme!suppliers!around!the!world!so!that!you!can!easily!identify!the!most!conveniently!located!providers.!

The!Enzyme!Sources!Guide!lists!all!the!suppliers!of!immobilized!enzymes!so!that!so!can!quickly!identify!a!supplier!for!immobilized!biocatalysts.!

Each!company!profile!provides!an!overview!of!each!company’s!offerings,!history,!size,!financial!heath,!technology,!and!R!&!D!capabilities.!!This!information!was!gathered!mostly!from!public!sources!including!regulatory!filings,!published!scientific!articles,!patents,!press!articles,!company!websites,!public!presentations,!and!similarly!available!sources.!!In!some!cases,!the!companies!themselves!provided!us!with!additional!information!via!interviews!or!other!communication.!!!

In!addition,!Tables!list!enzyme!companies!by!geographical!location,!enzyme!market,!and!specialization.!A!separate!section!listing!150+!enzyme!distributors!around!the!world!is!also!included.!

We!hope!you!will!find!the!Enzyme!Sources!Guide!to!be!an!indispensable!resource!and!information!source!about!companies!in!the!enzyme!industry.!

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Disclaimer:!We!have!tried!to!insure!that!the!information!provided!here!is!accurate!as!of!the!date!of!publication,!but!the!enzyme!market!is!rapidly!changing.!Some!recent!changes!in!companies!and!product!lines!may!not!be!incorporated!here,!and!we!cannot!guarantee!that!some!innacuracies!may!be!present.!This!guide!is!not!intended!to!be,!and!should!not!be!construed!as,!legal!or!financial!advice.!!!

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Copyright!©!2014!by!Sustainable!Chemistry!Solutions,!Inc.!

Copying!or!redistribution!of!this!publication!is!forbidden!by!law.!! !

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Table'of'Contents'

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Table!1:!Companies!Classified!by!Types!of!Enzymes!Produced!or!Sold!!………………….………….……….…!!5:13!

Table!2:!Companies!Classified!as!Manufacturers,!Distributors,!and!Service!Providers!………….….…..!14:24!

Table!3:!Enzyme!Companies!Offering!Immobilized!Enzymes,!Materials,!Services!………………………………!25!

Table!4:!Enzyme!Companies!Listed!According!Geographical!Location!or!Sales!Region!……………….…!26:40!

Profiles!of!Enzyme!Companies!Worldwide,!Listed!Alphabetically!…………………………………………………!41:414!

Distributors!of!Animal!Feed!Enzymes!World:wide!………………………………………………………………..…..!415:448!

Distributors!of!Life!Science!Enzymes!World:wide!……………….…………………………………………………….!449:465!

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Table'1:'Companies'Categorzed'by'Types'of'Enzymes'Produced/Sold'

Compa

ny!

Biocatalysts!

Textiles!a

nd!

Detergen

ts!

Pulp!and

!Pap

er!

Food

,!Baking,!and

!Juices!

Winem

aking!an

d!Brew

ing!

Anim

al!fe

ed!

Oil!Field!

Diagno

stic!and

!An

alytical!

Leathe

r!

Carboh

ydrates!

Other!

Molecular!Biology!

AB!Enzymes! 'x' x' x' x' x'

' ' 'x'

' 'AB!Vista! ' ' ' ' '

x'' ' ' ' ' '

Acore!Pharmatech! x'' ' ' ' ' '

x'' ' ' '

Actygea! ' ' ' ' ' ' ' ' ' ' ' 'Addiseo! ' ' ' ' '

x'' ' ' ' ' '

Advanced!Enzyme!Technologies,!Ltd.! x' x' x' x' x' x'

' 'x' x'

' '

Agrimex! ' ' ' ' 'x'

' ' ' ' ' 'Ajinomoto! ' ' '

x'' ' ' ' ' ' ' '

Aldevron! ' ' ' ' ' ' ' ' ' ' ' 'Alea!Evolution! ' ' ' '

x'' ' ' ' ' ' '

Alfa!Kimya!Company! 'x'

' ' ' ' ' ' ' ' ' 'AlfaNzyme!Bio:Tech! '

x' x' x' x' x'' ' ' ' ' '

Alliance!Enzyme!Pvt!Ltd! ' ' '

x'' ' ' ' ' ' ' '

Alltech!USA! ' ' ' ' 'x'

' ' ' ' ' 'Almac!Sciences! x'

' ' ' ' ' ' ' ' ' ' 'Alpha!Diagnostic!International! ' ' ' ' ' ' '

x'' ' ' '

Amano!Enzyme!Co.!Ltd.! x'

' 'x'

'x'

'x'

' ' ' '

American!Biosystems! 'x'

' ' 'x'

' ' ' ' ' 'American!Laboratories,!Inc! ' ' '

x''

x''

x'' ' ' '

Americos!Industries!Inc! ' '

x' x'' ' ' ' ' ' ' '

Amit!Biotech!Pvt.!Ltd.! ' ' ' ' 'x'

' ' ' ' ' 'AMPLICON! ' ' ' ' ' ' ' ' '

x''

x'

Ampliqon!A/S! ' ' ' ' ' ' ' ' ' ' 'x'

ANC!Enzymes! 'x' x' x' x' x'

' ' ' ' ' 'Andrés!Pintaluba,!S.A.!!!!! ' ' ' ' '

x'' ' ' ' ' '

Anil!Bioplus! 'x' x' x' x' x'

' 'x'

' ' 'Anthem!Cellutions! '

x' x' x'' '

x''

x'' ' '

Apollo!Chemical!Company! ' '

x'' ' ' ' ' ' ' ' '

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Compa

ny!

Biocatalysts!

Textiles!a

nd!

Detergen

ts!

Pulp!and

!Pap

er!

Food

,!Baking,!and

!Juices!

Winem

aking!an

d!Brew

ing!

Anim

al!fe

ed!

Oil!Field!

Diagno

stic!and

!An

alytical!

Leathe

r!

Carboh

ydrates!

Other!

Molecular!Biology!

Apollo!Scientific! 'x'

' ' ' ' 'x'

' ' 'x'

Applied!Biotechnology!Institute! ' ' ' ' ' ' ' ' ' ' ' '

Archaenzyme!Ltd! x'' ' ' ' ' ' ' ' ' ' '

ArcticZymes! ' ' ' ' ' ' 'x'

' ' 'x'

Ares!Bioscience!GmbH!(Genecraft)! ' ' ' ' ' ' ' ' ' ' '

x'

Arun!and!Co! ' ' ' ' ' ' 'x'

' ' 'x'

ASA!Spezialenzyme!GmbH! x' x' x'

' ' ' 'x'

' 'x'

'

Asahi!Kasei!Pharma! ' ' ' ' ' ' 'x'

' ' ' 'AUMEnzymes! '

x''

x' x' x'' '

x'' ' '

Aumgene! x' x' x' x' x' x'' '

x' x'' '

BASF!! 'x'

' ' 'x' x'

' ' ' ' 'BBI!Enzymes! ' ' ' ' ' ' '

x'' ' ' '

BehnMeyer! ' ' ' ' 'x'

' ' ' ' ' 'Beldem! ' ' '

x''

x'' ' ' ' ' '

Berg!+!Schmidt!GmbH!&!Co.!KG! ' ' ' ' '

x'' ' ' ' ' '

Bergerow! ' ' 'x' x'

' ' ' ' ' ' 'Berlin!Chemical! '

x'' ' ' ' ' ' ' ' ' '

BiCT!srl! x'' ' ' ' ' ' ' ' ' ' '

BIO:CAT! 'x'

'x' x' x'

' ' ' ' ' 'Biocat!Collection! x'

' ' ' ' ' ' ' ' ' ' 'Biocatalysts!Ltd.! ' ' '

x' x'' ' ' ' ' ' '

Biochem! ' ' ' ' 'x'

' ' ' ' ' 'Biomin! ' ' ' ' '

x'' ' ' ' ' '

BIO:PORT!Europe!s.r.o.! ' ' ' ' ' ' ' ' '

x''

x'

BioPox! 'x' x'

' ' ' ' ' ' 'x'

'Biorbyt!Ltd.!! ' ' ' ' ' ' '

x'' ' '

x'BioResearch!Products! x'

' ' ' ' ' 'x'

' ' ' '

Bioron!GmbH! ' ' ' ' ' ' ' ' ' ' 'x'

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Compa

ny!

Biocatalysts!

Textiles!a

nd!

Detergen

ts!

Pulp!and

!Pap

er!

Food

,!Baking,!and

!Juices!

Winem

aking!an

d!Brew

ing!

Anim

al!fe

ed!

Oil!Field!

Diagno

stic!and

!An

alytical!

Leathe

r!

Carboh

ydrates!

Other!

Molecular!Biology!

Bioseutica! ' ' 'x' x' x'

' ' ' ' ' 'BioSphere! x'

' ' ' ' ' ' ' ' ' ' 'biovet! ' ' ' ' '

x'' ' ' ' ' '

Biozym! ' ' ' ' ' ' ' ' ' ' 'x'

BioZyme! ' ' ' ' ' ' ' ' ' ' 'x'

BRAIN!AG! ' ' ' ' ' ' ' ' ' ' ' 'Brenntag! ' ' ' ' '

x'' ' ' ' ' '

BSC!Biochemicals! ' ' 'x'

'x'

' ' ' ' ' 'C.Schliessmann! ' ' ' '

x'' ' ' ' ' ' '

C5.6!Technologies! ' ' ' ' ' ' ' ' 'x'

' 'Calzyme! ' ' ' ' ' ' '

x'' '

x''

Cambrex!IEP!GmbH! ' ' ' ' ' ' ' ' ' ' ' 'Cellectis!SA! ' ' ' ' ' ' ' ' ' ' '

x'

Centerchem! ' ' 'x'

' ' ' ' ' ' ' 'Chematics! ' ' ' ' ' ' '

x'' ' ' '

CHEMOS!GmbH! x'' ' ' ' ' ' ' ' '

x''

Chimab! ' ' 'x'

' ' ' ' ' ' ' 'Chiral!Vision! x'

' ' ' ' ' ' ' ' ' ' 'Chr.!Hansen! ' ' '

x'' ' ' ' ' ' ' '

CHT/BEZEMA! 'x'

' ' ' ' ' ' ' ' ' 'CLEA!Technologies! x'

' ' ' ' ' ' ' ' ' ' 'c:LEcta!GmbH! x'

' ' ' ' ' ' ' ' 'x'

'Codexis,!Inc.! x'

' ' ' ' ' ' ' 'x'

' 'Colotex!Company!Ltd! '

x''

x''

x'' ' ' '

x''

Concord!Biotech! x'' ' ' ' ' ' ' ' ' ' '

Condor!Specialty!Products! '

x'' ' ' ' ' ' ' ' ' '

CPC!Biotech! x'' ' ' ' ' '

x'' ' ' '

Creative!BioMart! 'x' x' x' x' x'

'x' x'

'x'

'Deltagen!Bioproducts!N.A.! ' ' '

x'' ' ' ' ' ' ' '

Direvo!Industrial!Biotechnology!GmbH! ' ' ' ' ' ' ' ' '

x'' '

Discovery!Biocatalysts! x'

' ' ' ' ' ' ' ' ' ' '

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Compa

ny!

Biocatalysts!

Textiles!a

nd!

Detergen

ts!

Pulp!and

!Pap

er!

Food

,!Baking,!and

!Juices!

Winem

aking!an

d!Brew

ing!

Anim

al!fe

ed!

Oil!Field!

Diagno

stic!and

!An

alytical!

Leathe

r!

Carboh

ydrates!

Other!

Molecular!Biology!

DNA!Polymerase!Technology!Inc.! ' ' ' ' ' ' ' ' ' ' '

x'

Dong!Nam!Chemicals!&!Equipments!Corporation! ' ' ' ' ' ' '

x''

x'' '

DSM! ' ' 'x' x' x'

' 'x'

' ' 'DuPont!(Danisco:Genencor)! '

x' x' x' x' x'' ' ' ' ' '

Dyadic! 'x' x' x'

' ' ' ' 'x'

' 'DyStar! '

x'' ' ' ' ' ' ' ' ' '

Elanco!(Chem!Gen)! ' ' ' ' 'x'

' ' ' ' ' 'elementalenzymes! ' ' ' ' ' ' ' ' ' ' ' 'EMELCA!Bioscience! ' ' ' ' ' ' '

x''

x'' '

Emp!Biotech!GmbH! ' ' ' ' ' ' ' ' ' 'x'

'Enantis! ' ' ' ' ' ' ' ' ' '

x''

Enartis!Vinquiry! ' ' ' 'x'

' ' ' ' ' ' 'Engrain! ' ' '

x'' ' ' ' ' ' ' '

ENGroup! ' ' ' ' 'x'

' ' ' ' ' 'EnMex!SA!DE!CV! '

x''

x' x' x'' '

x'' ' '

Enzagen! x' ' ' ' ' ' ' ' ' ' ' '

Enzybel!International! ' ' 'x'

'x'

' ' ' ' ' 'Enzymatic!Deinking!Technologies,!LLC! ' '

x'' ' ' ' ' ' ' ' '

Enzymatics! ' ' ' ' ' ' ' ' ' ' 'x'

Enzyme!Development!Corporation! '

x' x' x' x'' ' ' ' ' ' '

Enzyme!Solutions! x' x' x' x'' ' ' '

x' x'' '

Enzyme!Solutions!(USA)! ' ' ' ' ' ' ' ' ' '

x''

Enzyme!Supplies! ' 'x' x' x'

' 'x'

'x'

' 'EnzymeKing!Biotechnology!Co.!Ltd! ' ' '

x'' ' ' ' ' '

x''

Enzymes!Naveen! 'x'

'x'

' ' ' ' ' ' ' 'EnzymeWorks! x'

' ' ' ' ' ' ' ' ' ' '

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Compa

ny!

Biocatalysts!

Textiles!a

nd!

Detergen

ts!

Pulp!and

!Pap

er!

Food

,!Baking,!and

!Juices!

Winem

aking!an

d!Brew

ing!

Anim

al!fe

ed!

Oil!Field!

Diagno

stic!and

!An

alytical!

Leathe

r!

Carboh

ydrates!

Other!

Molecular!Biology!

Enzymicals!AG! x'' ' ' ' ' ' ' ' ' ' '

Enzymology!Research!Center!Inc! ' ' ' ' ' ' ' ' ' '

x''

Enzyvia!LLC! ' ' ' ' 'x'

' ' ' ' ' 'epicentre! ' ' ' ' ' ' ' ' ' '

x' x'

epygen! 'x' x' x'

'x' x'

'x' x'

' 'ERA!Biotech! ' ' ' ' ' ' ' ' ' ' ' 'Erbsloh!Geisenheim!AG! ' ' ' '

x'' ' ' ' ' ' '

Eucodis!Biosciences!GmbH! x'

' ' ' ' ' ' ' ' ' ' '

Evocatal!GmbH! x'' ' ' ' ' ' ' ' ' ' '

Fenkin!Kimya!Sanayi!Ve!Ticaret!Ltd! '

x'' ' ' ' ' ' ' ' ' '

Fermenta!Biotech!Ltd! x'' ' ' ' ' ' ' ' ' ' '

Fermentia! x'' ' ' ' ' ' ' ' ' ' '

Fytozimus! ' ' 'x'

' ' ' ' ' ' ' 'Galilaeus!Oy! ' ' ' ' ' ' ' ' ' ' ' 'Genkim! '

x'' ' ' ' ' ' ' ' ' '

GenScript!USA!Inc! ' ' ' ' ' ' ' ' ' 'x'

'GNCBioferm! ' ' ' ' '

x'' ' ' ' ' '

Habio!Bioengineering!(Sichuan)! x'

' 'x'

'x'

' ' 'x'

' '

Huvepharma! ' ' ' ' 'x'

' ' ' ' ' 'IBEX! ' ' ' ' ' ' ' ' ' '

x''

Imperial!Jade!Bio:Technology!Co.,!Ltd.! ' ' '

x''

x'' '

x'' ' '

Infinite!Enymzes! ' ' ' ' ' ' ' ' 'x'

' 'InnoTech!MSU! x'

' ' ' ' ' 'x'

' ' ' 'Iris!Biotech!GmbH! x'

' ' ' ' ' ' ' ' ' ' 'Jena!Bioscience!GmbH! ' ' ' ' ' ' ' ' ' ' '

x'

Jiangsu!Boli!Bioproducts!Co.!Ltd! '

x''

x' x' x'' ' '

x'' '

Jiangsu!OGO!Biotech!Co.,!Ltd.! ' ' ' ' ' ' ' ' '

x'' '

! ! !!



Compa

ny!

Biocatalysts!

Textiles!a

nd!

Detergen

ts!

Pulp!and

!Pap

er!

Food

,!Baking,!and

!Juices!

Winem

aking!an

d!Brew

ing!

Anim

al!fe

ed!

Oil!Field!

Diagno

stic!and

!An

alytical!

Leathe

r!

Carboh

ydrates!

Other!

Molecular!Biology!

Jinan!Tiantianxiang!Co.,!Ltd.! ' ' ' ' '

x'' ' ' ' ' '

Johnson!Matthey! x'' ' ' ' ' ' ' ' ' ' '

Kemikalia! ' ' 'x'

' ' ' ' ' ' ' 'Kemin! ' ' ' ' '

x'' ' ' ' ' '

Kerry!Americas! ' ' 'x'

' ' ' ' ' ' ' 'Kiotechagil! ' ' ' ' '

x'' ' ' ' ' '

Kiwienzyme.com!Ltd! ' ' 'x'

' ' ' ' ' 'x'

'Lactosan!GmbH! ' ' ' ' ' ' ' ' ' ' ' 'Laffort! ' ' ' '

x'' ' ' ' ' ' '

Lallemand! ' ' 'x' x'

' ' ' ' ' ' 'Lamothe:Abiet! ' ' ' '

x'' ' ' ' ' ' '

Lanxess! ' ' ' ' ' ' ' 'x'

' ' 'Larbus!s.a.! ' ' '

x'' ' ' ' ' ' ' '

Lentikats!Biotechnologies! ' ' ' ' ' ' ' ' ' ' ' '

Leveking!Enzymes! ' 'x' x'

'x'

' ' ' ' ' 'Libragen! x'

' ' ' ' ' ' ' ' 'x'

'Life!Technologies!(GeneArt)! ' ' ' ' ' ' ' ' ' ' '

x'

Lonza! ' ' ' ' ' ' ' ' ' ' 'x'

Lucigen! ' ' ' ' ' ' ' ' 'x'

'x'

Lumis!Biotech! 'x'

'x' x' x'

' ' ' ' ' 'Lybradyn! x'

' ' ' ' ' ' ' ' 'x'

'Lyven! '

x''

x' x' x'' ' ' ' ' '

M!L!CHEMICALS!(INDIA)!PVT!LTD.! '

x'' ' ' ' ' '

x'' ' '

Maps!Enzyme!Limited! '

x''

x' x' x'' '

x'' ' '

Megazyme!Ireland! 'x'

'x' x' x'

'x'

'x'

' 'Meito!Sangyo! x'

' ' ' ' ' ' ' ' ' ' 'Menlo!Biotech/Ecozymes! ' ' ' ' ' ' ' ' '

x' x''

Merck!KGaA!(EMD!Millipore,!Calbiochem)!

x'' ' ' ' ' ' ' ' ' '

x'

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Compa

ny!

Biocatalysts!

Textiles!a

nd!

Detergen

ts!

Pulp!and

!Pap

er!

Food

,!Baking,!and

!Juices!

Winem

aking!an

d!Brew

ing!

Anim

al!fe

ed!

Oil!Field!

Diagno

stic!and

!An

alytical!

Leathe

r!

Carboh

ydrates!

Other!

Molecular!Biology!

Metabomics! x'' ' ' ' ' ' ' ' ' ' '

Metgen!Oy! ' 'x'

' ' ' ' ' 'x'

' 'Millbo! ' ' '

x'' ' ' ' ' ' ' '

Mirpain! ' ' 'x'

' ' ' ' ' ' ' 'Mühlenchemie! ' ' '

x'' ' ' ' ' ' ' '

MP!Biomedical! x'' ' ' ' ' '

x'' '

x' x'

Nagase! 'x'

'x' x'

' ' ' ' ' ' 'Najing!Chemlin!Chemical!Industry! x'

' ' ' ' ' ' ' 'x'

' '

NEB! ' ' ' ' ' ' ' ' ' ' 'x'

Nordmann,!Rassmann! ' ' '

x'' ' ' ' ' ' ' '

Novozymes! 'x' x' x' x' x'

' 'x' x'

' 'Novus! ' ' ' ' '

x'' ' ' ' ' '

Nutreco! ' ' ' ' 'x'

' ' ' ' ' 'Nzomics!Biocatalysis! x'

' ' ' ' ' ' ' ' ' ' 'NZYTech! ' ' ' ' ' ' '

x''

x''

x'

OenoBioTech!SAS! ' ' ' 'x'

' ' ' ' ' ' 'Oenobrands! ' ' ' '

x'' ' ' ' ' ' '

OptiGene! ' ' ' ' ' ' ' ' ' ' 'x'

ORBA! ' ' 'x' x' x'

' ' ' ' ' 'Oriental!Yeast! x'

' ' ' ' ' 'x'

' ' ' 'Parchem! ' ' '

x''

x'' ' ' ' ' '

Prochimica!Group! 'x'

' ' ' ' ' ' ' ' ' 'Proenzimas!Ltda! ' ' '

x' x' x'' ' ' ' ' '

Promega! ' ' ' ' ' ' ' ' ' 'x' x'

Protean! ' ' ' ' ' ' ' ' ' ' ' 'Proteogen!Bio! ' ' ' ' ' ' ' ' ' '

x''

Prozomix! x'' ' ' ' ' ' ' ' ' ' '

Prozyme! ' ' ' ' ' ' 'x'

' ' ' 'Purolite! x'

' ' ' ' ' ' ' ' ' ' 'Research!Products!Company! ' ' '

x'' ' ' ' ' ' ' '

Roal!Oy! 'x' x' x' x' x'

' ' ' ' ' 'RobinsonBioproducts! ' ' ' ' '

x'' ' ' ' ' '

! ! !!



Compa

ny!

Biocatalysts!

Textiles!a

nd!

Detergen

ts!

Pulp!and

!Pap

er!

Food

,!Baking,!and

!Juices!

Winem

aking!an

d!Brew

ing!

Anim

al!fe

ed!

Oil!Field!

Diagno

stic!and

!An

alytical!

Leathe

r!

Carboh

ydrates!

Other!

Molecular!Biology!

Roche! ' ' ' ' ' ' 'x'

' ' 'x'

Rossari!Biotech! 'x' x' x'

'x'

' 'x'

' ' 'S!I!CHEMICAL!INDUSTRIES! '

x''

x'' ' ' '

x'' ' '

Sartoris!Stedim!Biotech! ' ' ' ' ' ' ' ' ' ' '

x'

Scott!Laboratories! ' ' ' 'x'

' ' ' ' ' ' 'Season!Chemicals!Dyestuffs! '

x'' ' ' ' ' ' ' ' ' '

Sekisui!Enzymes! ' ' ' ' ' ' 'x'

' ' ' 'Senson!Ltd! ' ' '

x'' ' ' ' ' ' ' '

Shandong!Longda!Bio:Products!Co.,!Ltd.! '

x''

x''

x'' ' ' ' ' '

SHIN!NIHON!CHEMICAL!CO.,!LTD.! ' ' '

x'' ' ' ' ' ' ' '

SibEnzyme! ' ' ' ' ' ' ' ' ' ' 'x'

Sigma:Aldrich! x'' ' ' ' ' '

x'' '

x' x'

SinoBios!! 'x' x' x' x' x'

' 'x'

' ' 'Specialty!Enzymes!and!Biotechnologies!Inc.! '

x' x' x' x' x'' '

x'' ' '

SpheriTech! x'' ' ' ' ' '

x'' ' ' '

Sprin! x'' ' ' ' ' ' ' ' ' ' '

SternEnzym! ' ' 'x'

' ' ' ' ' ' ' 'Strem! x'

' ' ' ' ' ' ' ' ' ' 'Sukahan! '

x' x'' '

x'' ' ' ' ' '

Sunson!Industry!Group!Company!Limited! '

x''

x' x' x'' '

x'' ' '

SynBioCat!Ltd! x'' ' ' ' ' ' ' ' ' ' '

Syncozymes! x'' ' ' ' ' '

x'' ' ' '

Takabio! ' ' 'x'

' ' ' ' ' ' ' 'tebu:bio! ' ' ' ' ' ' '

x'' '

x' x'

Tegaferm! ' ' 'x' x'

' ' ' ' ' ' 'Tex!Biosciences! '

x' x'' '

x'' '

x'' ' '

The!Seydel! 'x'

' ' ' ' ' ' ' ' ' '

! ! !!



Compa

ny!

Biocatalysts!

Textiles!a

nd!

Detergen

ts!

Pulp!and

!Pap

er!

Food

,!Baking,!and

!Juices!

Winem

aking!an

d!Brew

ing!

Anim

al!fe

ed!

Oil!Field!

Diagno

stic!and

!An

alytical!

Leathe

r!

Carboh

ydrates!

Other!

Molecular!Biology!

Companies!

ThermoFisher! ' ' ' ' ' ' ' ' ' ' 'x'

Toyobo!Enzymes! ' ' ' ' ' ' 'x'

' ' ' 'TransBiodiesel! ' ' ' ' ' ' ' ' ' '

x''

Tri:Tex!Co! 'x'

' ' ' ' ' ' ' ' ' 'Ultra!Bio:Logics!Inc.! ' ' ' ' '

x'' ' ' ' ' '

Unikbio!Biotech(Guangzhou)!Ltd! ' '

x' x' x'' ' ' ' ' ' '

Unitaka! x'' ' ' ' ' '

x'' ' ' '

VEMO!99!Ltd!! ' ' 'x'

'x'

' ' ' ' ' 'Verenium! '

x' x'' '

x' x''

x'' ' '

Veskim! 'x'

' ' ' ' ' ' ' ' ' 'W42!Industrial!Biotechnology!GmbH! x'

' ' ' ' ' ' ' ' ' ' 'Wako!Pure!Chemical!Industries! ' ' ' ' ' ' '

x'' ' ' '

Weiss!Biotech!GmbH! ' ' 'x' x'

' ' ' 'x'

' 'Worthington! x'

' ' ' ' ' 'x'

' 'x' x'

Yakult! ' ' 'x' x' x'

' ' ' 'x'

'Zymetech! ' ' ' ' ' ' ' ' ' '

x''

Zytex! 'x'

' ' ' ' ' ' ' ' ' ''

'

'

'

'

' '

! ! !!


'

Table'2:'Classification'as'Manufacturers,'Distributors,'Service'Providers'Co

mpa

ny!

Head

quarters!

Web

site!

Prim

ary!

Man

ufacturer!

Distrib

utor!

Contract!

Man

ufacturer!

Contract!

Research!

Service!

AB!Enzymes! Germany! www.abenzymes.com!! x'' ' '

AB!Vista! UK! www.abvista.com!! 'x'

' 'Acore!Pharmatech! USA! www.acorePharmatech.com!! '

x'' '

Actygea! Italy! www.actygea.com!! ' ' 'x'

Addiseo! France! www.adisseo.com!! x'' ' '

Advanced!Enzyme!Technologies,!Ltd.! India!

www.advancedenzymes.com!!

x'' ' '

Agrimex! Belgium! www.agrimex.be!! 'x'

' 'Ajinomoto! Japan! www.ajinomoto.com!! x'

' ' 'Aldevron! USA! www.aldevron.com!! ' '

x' x'

Alea!Evolution! Italy! www.alea:evolution.com!! 'x'

' 'Alfa!Kimya!Company! Turkey! www.en.alfakimya.com!!!!! '

x'' '

AlfaNzyme!Bio:Tech! India! www.alfanzymebiotech.com!! '

x'' '

Alliance!Enzyme!Pvt!Ltd! India! www.papainenzyme.com!! x' x'

' '

Alltech!USA! USA! www.alltech.com!! 'x'

' 'Almac!Sciences! UK! www.almacgroup.com!! x' x'

'x'

Alpha!Diagnostic!International! USA! www.4adi.com!! '

x'' '

Amano!Enzyme!Co.!Ltd.! Japan! www.amano:enzyme.co.jp!! x' x'

' 'American!Biosystems! USA!

www.americanbiosystems.com!! '

x'' '

American!Laboratories,!Inc! USA!

www.americanlaboratories.com!!

x''

x''

Americos!Industries!Inc! India! www.kenencoregroup.com!! '

x'' '

Amit!Biotech!Pvt.!Ltd.! India! www.amitbiotech.com!! '

x'' '

! ! !!


Table'2:'Classification'as'Manufacturers,'Distributors,'Service'Providers'

Compa

ny!

Head

quarters!

Web

site!

Prim

ary!

Man

ufacturer!

Distrib

utor!

Contract!

Man

ufacturer!

Contract!

Research!

Service!

AMPLICON!Czech!Republic! www.amplicon.cz!!

'x'

' '

Ampliqon!A/S! Denmark! www.ampliqon.com!! x'' ' '

ANC!Enzymes! Singapore! www.ancenzymes.com!! 'x'

' 'Andrés!Pintaluba,!S.A.!!!!! Spain! www.pintaluba.com!! '

x'' '

Anil!Bioplus! India! www.anilbioplus.com!! x'' ' '

Anthem!Cellutions! India! www.anthemcell.com!! x'

' ' 'Apollo!Chemical!Company! USA! www.apollochemical.com!! '

x'' '

Apollo!Scientific! UK! www.apolloscientific.co.uk!! 'x'

' 'Applied!Biotechnology!Institute! USA! www.appliedbiotech.org!! ' '

x' x'

Archaenzyme!Ltd! Israel! www.archaezyme.com!! ' '

x' x'

ArcticZymes! Norway! www.arcticzymes.com!!! x'' ' '

Ares!Bioscience!GmbH!(Genecraft)! Germany! www.genecraft.de!! '

x'' '

Arun!and!Co! India! www.arunandco.com!! 'x'

' 'ASA!Spezialenzyme!GmbH! Germany! www.asa:enzyme.de!!

x''

x' x'

Asahi!Kasei!Pharma! Japan! www.asahi:kasei.com!! x'

' ' '

AUMEnzymes! India! www.aumenzymes.com!! x'' ' '

Aumgene! India! www.aumgene.com!! x''

x' x'

BASF!! Germany! www.basf.com!! x'' ' '

BBI!Enzymes! UK! www.bbienzymes.com!! x'' ' '

BehnMeyer! Germany! www.behnmeyer.com!! 'x'

' 'Beldem! Belgium! www.beldem.com!! x'

' ' 'Berg!+!Schmidt!GmbH!&!Co.!KG! Germany! www.berg:schmidt.de!! '

x'' '

Bergerow! Germany! www.begerow.com!! 'x'

' 'Berlin!Chemical! China! www.berlinchem.com!! '

x'' '

BiCT!srl! Italy! www.bict.it!! x''

x' x'

! ! !!



Compa

ny!

Head

quarters!

Web

site!

Prim

ary!

Man

ufacturer!

Distrib

utor!

Contract!

Man

ufacturer!

Contract!

Research!

Service!

BIO:CAT! USA! www.bio:cat.com!! 'x'

' 'Biocat!Collection! Germany! www.biocatcollection.net!! '

x'' '

Biocatalysts!Ltd.! UK! www.biocatalysts.com!!!! x''

x' x'

Biochem! Germany! www.biochem.net!! 'x'

' 'Biomin! Austria! www.biomin.net!! x'

' ' 'BIO:PORT!Europe!s.r.o.!

Czech!Republic! www.bio:port.cz!!!! '

x'' '

BioPox! Italy! www.biopox.com!! x'' '

x'

Biorbyt!Ltd.!! UK! www.biorbyt.com!! 'x'

' 'BioResearch!Products! USA! www.bio:researchprod.com!! x'

'x' x'

Bioron!GmbH! Germany! www.bioron.net!! x'' ' '

Bioseutica! Netherlands! www.bioseutica.com!! x'' ' '

BioSphere! Italy! www.biospheresrl.com!! x''

x' x'

biovet! Bulgaria! www.biovet.com!! x'' ' '

Biozym! Germany! www.biozym.com!!!! 'x'

' 'BioZyme! Romania! www.biozyme.ro!!! '

x'' '

BRAIN!AG! Germany! www.brain:biotech.de!! ' ' 'x'

Brenntag! Germany! www.brenntag.com!! 'x'

' 'BSC!Biochemicals! !Belgium! www.bscbio.be!! x'

' ' '

C.Schliessmann! Germany! www.c:schliessmann.de!! 'x'

' 'C5.6!Technologies! USA! www.c56technologies.com!!!! x'

' ' '

Calzyme! USA! www.calzyme.com!! x'' ' '

Cambrex!IEP!GmbH! USA! www.cambrex.com!! ' ' '

x'

Cellectis!SA! France! www.cellectis.com!! x'' ' '

Centerchem! USA! www.centerchem.com!! 'x'

' 'Chematics! USA! www.chematics.com!! x'

' ' 'CHEMOS!GmbH! Germany! www.chemos:group.com!! '

x'' '

Chimab! Italy! www.chimab.it!! ?'' ' '

Chiral!Vision! Netherlands! www.chiralvision.com!! x''

x' x'

Chr.!Hansen! Denmark! www.chr:hansen.com!! x'' ' '

CHT/BEZEMA! Germany! www.cht:group.com!! ?'' ' '

! ! !!



Compa

ny!

Head

quarters!

Web

site!

Prim

ary!

Man

ufacturer!

Distrib

utor!

Contract!

Man

ufacturer!

Contract!

Research!

Service!

CLEA!Technologies! Netherlands! www.cleatechnologies.com!! x'

' ' '

c:LEcta!GmbH! Germany! www.c:lecta.com!! x''

x' x'

Codexis,!Inc.! USA! www.codexis.com!! x'' '

x'Colotex!Company!Ltd! Hong!Kong! www.colotexbiotech.com!! x'

' ' 'Concord!Biotech! India! www.concordbiotech.com!! x'

' ' 'Condor!Specialty!Products! USA! www.condorspecialty.com!! '

x'' '

CPC!Biotech! Italy! www.cpcbiotech.it!! x''

x' x'Creative!BioMart! USA! www.creativebiomart.net!! x' x' x' x'

Deltagen!Bioproducts!N.A.!

Netherlands!Antilles! www.deltagenbiop.com!!! '

x'' '

Direvo!Industrial!Biotechnology!GmbH! Germany! www.direvo.com!!

x'' ' '

Discovery!Biocatalysts! UK! www.discovery:bc.co.uk!! '

x''

x'

DNA!Polymerase!Technology!Inc.! USA! www.klentaq.com!!

x'' ' '

Dong!Nam!Chemicals!&!Equipments!Corporation! Vietnam! www.dongnamlab.com!!

'x'

' '

DSM! Netherlands! www.dsm.com!! x'' ' '

DuPont!(Danisco:Genencor)! USA! www.dupont.com!!

x'' ' '

Dyadic! USA! www.dyadic.com!!! x''

x' x'

DyStar! Germany! www.dystar.com!! 'x'

' 'Elanco!(Chem!Gen)! USA! www.elanco.us!! x'

' ' '

elementalenzy USA! www.elementalenzymes.co ' ' 'x'

! ! !!



Compa

ny!

Head

quarters!

Web

site!

Prim

ary!

Man

ufacturer!

Distrib

utor!

Contract!

Man

ufacturer!

Contract!

Research!

Service!

mes! m!!EMELCA!Bioscience! Belgium! www.emelcabio.com!!! '

x'' '

Emp!Biotech!GmbH! Germany! www.empbiotech.com!! x'

' ' '

Enantis!Czech!Republic! www.enantis.com!! x'

' 'x'

Enartis!Vinquiry! Italy! www.enartis.com!! 'x'

' 'Engrain! USA! www.engrain.us!! '

x'' '

ENGroup! China! www.engroup.cn!! x'' ' '

EnMex!SA!DE!CV! Mexico! www.enzymes.com.mx!! x'

' ' '

Enzagen! UK! www.enzagen.com! ' x' ' 'Enzybel!International! !Belgium! www.enzybel.com!! x'

' ' 'Enzymatic!Deinking!Technologies,!LLC! USA! www.edt:enzymes.com!!

'x'

' '

Enzymatics! USA! www.enzymatics.com!! x''

x''

Enzyme!Development!Corporation! USA!

www.EnzymeDevelopment.com!!

x' x'' '

Enzyme!Solutions! Australia!

www.enzymesolutions.com.au!! '

x'' '

Enzyme!Solutions!(USA)! USA! www.enzymesolutions.com!! x'

'x'

'Enzyme!Supplies! UK! www.enzymesupplies.com!! '

x'' '

EnzymeKing!Biotechnology!Co.!Ltd! China! www.enzymeking.com!!

x'' ' '

Enzymes!Naveen! India! !! '

x'' '

EnzymeWorks! China! www.enzymeworking.com!! x''

x' x'

Enzymicals!AG! Germany! www.enzymicals.com!!! x''

x' x'Enzymology!Research!Center!Inc! USA! www.ercenzymes.com!!

x''

x''

! ! !!



Compa

ny!

Head

quarters!

Web

site!

Prim

ary!

Man

ufacturer!

Distrib

utor!

Contract!

Man

ufacturer!

Contract!

Research!

Service!

Enzyvia!LLC! USA! www.enzyvia.com!! x'' ' '

epicentre! USA! www.epibio.com!! x''

x''

epygen! UAE! www.epygen.com!! x'' ' '

ERA!Biotech! Spain! www.erabiotech.com!! ' 'x' x'

Erbsloh!Geisenheim!AG! Germany! www.erbsloeh.com!! x' x'

' 'Eucodis!Biosciences!GmbH! Austria! www.eucodis.com!!

x' x' x' x'

Evocatal!GmbH! Germany! www.evocatal.com!! x'' '

x'Fenkin!Kimya!Sanayi!Ve!Ticaret!Ltd! Turkey! www.fenkim.com!! '

x'' '

Fermenta!Biotech!Ltd! India! www.fermentabiotech.com!! x'

' 'x'

Fermentia! Hungary! www.fermentia.eu!! x''

x' x'

Fytozimus! Canada! www.fytozimus.com!! x'' ' '

Galilaeus!Oy! Finland! www.galilaeus.fi!! ' 'x'

'Genkim! Turkey! www.genkim.com.tr!! '

x'' '

GenScript!USA!Inc! USA! www.genscript.com!! x'

'x'

'

GNCBioferm! Canada! www.gncbioferm.ca!! x'' ' '

Habio!Bioengineering! Bulgaria! www.habio.net!! x'

' ' '

Huvepharma! Bulgaria! www.huvepharma.com!! x'' ' '

IBEX! Canada! www.ibex.ca!! x'' ' '

Imperial!Jade!Bio:Technology!Co.,!Ltd.! China!

www.imperialjade12.en.china.cn!!

x'' ' '

Infinite!Enymzes! USA! www.infiniteenzymes.com!!! x'

' ' '

InnoTech!MSU! Russia! www.innotech:msu.com!! x'' ' '

Iris!Biotech!GmbH! Germany! www.iris:biotech.de!! '

x'' '

Jena!Bioscience!GmbH! Germany! www.jenabioscience.com!! x' x'

' 'Jiangsu!Boli!Bioproducts!Co.! China! www.bolibio.com!! x'

' ' '

! ! !!



Compa

ny!

Head

quarters!

Web

site!

Prim

ary!

Man

ufacturer!

Distrib

utor!

Contract!

Man

ufacturer!

Contract!

Research!

Service!

Ltd!Jiangsu!OGO!Biotech!Co.,!Ltd.! China! www.ogo:biotech.com!!

x'' ' '

Jinan!Tiantianxiang!Co.,!Ltd.! China! www.jnttx.com!!

x'' ' '

Johnson!Matthey! UK! www.jmcct.com!! x'

' ' '

Kemikalia! Sweden! www.kemikalia.se!! x'' ' '

Kemin! USA! www.kemin.com!! 'x'

' 'Kerry!Americas! USA! www.kerry.com!! '

x'' '

Kiotechagil! UK! www.kiotechagil.com!! x'' ' '

Kiwienzyme.com!Ltd!

New!Zealand! www.kiwienzyme.com!! x'

' ' '

Lactosan!GmbH! Austria! www.lactosan.at!! ' 'x'

'Laffort! France! www.laffort.com!! '

x'' '

Lallemand! Canada! www.lallemand.com!! 'x'

' 'Lamothe:Abiet! France! www.lamothe:abiet.com!! '

x'' '

Lanxess! Germany! www.lanxess.com!!!! 'x'

' 'Larbus!s.a.! Spain! www.larbus.com!! '

x'' '

Lentikats!Biotechnologies!

Czech!Republic! www.lentikats.eu!! ' '

x' x'

Leveking!Enzymes! China! www.levekingenzymes.com!! x'

' ' '

Libragen! France! www.libragen.com!! x''

x' x'Life!Technologies!(GeneArt)! USA! www.lifetechnologies.com!!

x' x' x' x'

Lonza! Switzerland! www.lonza.com!! x'' ' '

Lucigen! USA! www.lucigen.com!!! x'' ' '

Lumis!Biotech! Inda! www.lumisbiotech.com!! x'' ' '

Lybradyn! USA! www.lybradyn.com!! x'' '

x'

Lyven! !France! www.lyven.com!! x'' ' '

M!L!CHEMICALS!(INDIA)!PVT!LTD.! India! www.mlindia.com!!

x'' ' '

! ! !!



Compa

ny!

Head

quarters!

Web

site!

Prim

ary!

Man

ufacturer!

Distrib

utor!

Contract!

Man

ufacturer!

Contract!

Research!

Service!

Maps!Enzyme!Limited! India! www.mapsenzymes.com!! x'

' ' 'Megazyme!Ireland! Ireland! www.megazyme.com!! x'

' ' '

Meito!Sangyo! Japan!www5.mediagalaxy.co.jp/meito/kaseihin/index_e.html!!! x'

' ' 'Menlo!Biotech/Ecozymes! UK! www.menlobiotech.com!!!! '

x'' '

Merck!KGaA!(EMD!Millipore,!Calbiochem)! Germany! www.emdgroup.com!! '

x'' '

Metabomics! China! www.metabomics.com!! ' 'x' x'

Metgen!Oy! Finland! www.metgen.fi!! x'' ' '

Millbo! Italy! www.millbo.com!! 'x'

' 'Mirpain! Turkey! www.mirpain.com!! '

x'' '

Mühlenchemie! Germany! www.muehlenchemie.de!! 'x'

' 'MP!Biomedical! USA! www.mpbio.com!! '

x'' '

Nagase! Japan! www.nagasechemtex.co.jp!! x'' ' '

Najing!Chemlin!Chemical!Industry! China!

www.chemlin.guidechem.com!! '

x'' '

NEB! USA! www.neb.com!! x''

x' x'Nordmann,!Rassmann! Germany!

www.nordmann:rassmann.com!! '

x'' '

Novozymes! Denmark! www.novozymes.com!! x'' ' '

Novus! USA! www.novusint.com!! 'x'

' 'Nutreco! Netherlands! www.nutreco.com!!!!! '

x'' '

Nzomics!Biocatalysis! UK! www.nzomics.com!! x'

' 'x'

NZYTech! Portugal! www.nzytech.com!! x'' ' '

OenoBioTech!SAS! France! www.oenobiotech.com!! '

x'' '

Oenobrands! France! www.oenobrands.com!! 'x'

' 'OptiGene! UK! www.optigene.co.uk!! x'

' ' 'ORBA! Turkey! www.orba.com.tr!! x'

' ' 'Oriental!Yeast! Japan! www.oyc.co.jp!! x'

' ' '

! ! !!



Compa

ny!

Head

quarters!

Web

site!

Prim

ary!

Man

ufacturer!

Distrib

utor!

Contract!

Man

ufacturer!

Contract!

Research!

Service!

Parchem! USA! www.parchem.com!! 'x'

' 'Prochimica!Group! Italy! www.prochimicagroup.com!! '

x'' '

Proenzimas!Ltda! Columbia! www.proenzimas.com!! '

x'' '

Promega! USA! www.promega.com!! x''

x''

Protean!Czech!Republic! www.protean.cz!! ' '

x' x'

Proteogen!Bio! Italy! www.proteogenbio.com!! x'' ' '

Prozomix! UK! www.prozomix.com!! x' x'' '

Prozyme! USA! www.prozyme.com!! x'' ' '

Purolite! USA! www.purolite.com!!! ' ' ' 'Research!Products!Company! USA! www.researchprod.com!!! '

x'' '

Roal!Oy! Finland! www.roal.fi!! x'' ' '

RobinsonBioproducts! Canada!

www.robinsonbioproducts.com!! '

x'' '

Roche! Switzerland! www.roche.com!! x'' ' '

Rossari!Biotech! India! www.rossari.com!! x'' ' '

S!I!CHEMICAL!INDUSTRIES! India! www.papain.in!! x'

' ' 'Sartoris!Stedim!Biotech! France! www.sartorius:stedim.com!! '

x'' '

Scott!Laboratories! USA! www.scottlab.com!! '

x'' '

Season!Chemicals!Dyestuffs! Hong!Kong! www.sesaonchemicals.com!! '

x'' '

Sekisui!Enzymes! UK! www.sekisuienzymes.com!! x''

x''

Senson!Ltd! Finland! www.senson.fi!! 'x'

' 'Shandong!Longda!Bio:Products!Co.,!Ltd.! China! www.enzymeinchina.com!!

x'' ' '

SHIN!NIHON!CHEMICAL!CO.,!LTD.! Japan!

www.aichi:brand.jp/corporate/type/chemical/shin:nihon:e.html!!

x'' ' '

! ! !!



Compa

ny!

Head

quarters!

Web

site!

Prim

ary!

Man

ufacturer!

Distrib

utor!

Contract!

Man

ufacturer!

Contract!

Research!

Service!

SibEnzyme! Russia! www.sibenzyme.com!! x'' ' '

Sigma:Aldrich! USA! www.sigmaaldrich.com!! 'x'

' 'SinoBios!! China! www.sinobios.com!! x' x'

' 'Specialty!Enzymes!and!Biotechnologies!Inc.! USA! www.specialtyenzymes.com!!

x' x'' '

SpheriTech! UK! www.spheritech.com!! ' ' 'x'

Sprin! Italy! www.sprintechnologies.com!! x''

x' x'

SternEnzym! Germany! www.sternenzym.de!! x' x'' '

Strem! USA! www.strem.com!! 'x'

' 'Sukahan! China! www.sukahan.com!! x'

' ' 'Sunson!Industry!Group!Company!Limited! China! www.chinaenzymes.com!!

x'' ' '

SynBioCat!Ltd! Hungary! www.synbiocat.hu!! x''

x' x'

Syncozymes! China! www.syncozymes.com!! x' x' x' x'

Takabio! France! www.takabio.com!! 'x'

' 'tebu:bio! France! www.tebu:bio.com!! x' x' x' x'

Tegaferm! Austrial! www.tegaferm.com!! 'x'

' 'Tex!Biosciences! India! www.texbiosciences.com!! x'

' ' 'The!Seydel!Companies! USA! www.seydel.com!! '

x'' '

ThermoFisher! USA! www.thermoscientific.com!! x'' ' '

Toyobo!Enzymes! Japan! www.toyobo:global.com!! x'

' ' '

TransBiodiesel! Israel! www.transbiodiesel.com!! x'' ' '

Tri:Tex!Co! Canada! www.tritex.com!! 'x'

' 'Ultra!Bio:Logics!Inc.! Canada! www.ublcorp.com!! x'

' ' 'Unikbio!Biotech(Guangzhou)!Ltd! China! www.unikbio.com!! '

x'' '

Unitaka! Japan! www.unitika.co.jp!! x'' ' '

VEMO!99!Ltd!! Bulgaria! www.vemo:vsv.com!! x'' ' '

Verenium! USA! www.verenium.com!! x'' ' '

! ! !!



Compa

ny!

Head

quarters!

Web

site!

Prim

ary!

Man

ufacturer!

Distrib

utor!

Contract!

Man

ufacturer!

Contract!

Research!

Service!

Veskim! Turkey! www.veskim.com!! 'x'

' 'W42!Industrial!Biotechnology!GmbH! Germany! www.w42biotechnology.de!!

x''

x' x'

Wako!Pure!Chemical!Industries! Japan! www.wako:chem.co.jp!!

x'' ' '

Weiss!Biotech!GmbH! Germany! www.weissbiotech.com!! '

x'' '

Worthington! USA!www.worthington:biochem.com!! x'

' ' '

Yakult! Japan! www.yakult.co.jp/ypi/en/!! x'' ' '

Zymetech! Iceland! www.zymetech.com!! x'' ' '

Zytex! India! www.zytex.com!!! x' x' x''

'

'

'

'

'

'

'

'

'

'

'

'

'

'

! ! !!


'

Table'3:'Companies'Offering'Immobilized'enzymes,'Materials,'Services'

'Com

pany

'

Hea

dBqu

arters'

Web

site'

Immob

ilized'

Enzymes'

Immob

ilizaB

tion

'service'

Solid

'pha

ses'

for'pu

rcha

se'

Acore!Pharmatech! USA! www.acorePharmatech.com!! x' x''

Advanced!Enzyme!Technologies,!Ltd.! India! www.advancedenzymes.com!! x'

' '

Almac!Sciences! UK! www.almacgroup.com!! 'x'

'Amano!Enzyme!Co! Japan! www.amano:enzyme.co.jp!! x'

' 'BiCT!srl! Italy! www.bict.it!! x' x'

'BioSphere! Italy! www.biospheresrl.com!! x' x'

'CHEMOS!GmbH! Germany! www.chemos:group.com!! x'

' 'Chiral!Vision! Netherlands! www.chiralvision.com!! x' x' x'

CLEA!Technologies! Netherlands! www.cleatechnologies.com!! x' x''

Codexis,!Inc.! USA! www.codexis.com!! x'' '

CPC!Biotech! Italy! www.cpcbiotech.it!! 'x'

'elementalenzymes! USA! www.elementalenzymes.com!! '

x''

Emp!Biotech!GmbH! Germany! www.empbiotech.com!! x'

' '

EnzymeWorks! China! www.enzymeworking.com!! 'x'

'Fermenta!Biotech!! India! www.fermentabiotech.com!! x' x' x'

Fermentia! Hungary! www.fermentia.eu!! x' x''

Iris!Biotech!GmbH! Germany! www.iris:biotech.de!! x'' '


Czech!Republic! www.lentikats.eu!! '

x' x'

Meito!Sangyo! Japan!www5.mediagalaxy.co.jp/meito/kaseihin/index_e.html!!! x'

' '

Proteogen!Bio! Italy! www.proteogenbio.com!! x'' '

Prozomix! UK! www.prozomix.com!! x'' '

Purolite! USA! www.purolite.com!!! ' 'x'

Sigma:Aldrich! USA! www.sigmaaldrich.com!! x'' '

SpheriTech! UK! www.spheritech.com!! 'x' x'

Sprin! Italy! www.sprintechnologies.com!! x' x' x'

SynBioCat!Ltd! Hungary! www.synbiocat.hu!! x' x''

Syncozymes! China! www.syncozymes.com!! x' x''

TransBiodiesel! Israel! www.transbiodiesel.com!! x'' '

W42!Industrial!Biotechnology!! Germany! www.w42biotechnology.de!! x' x'

'

Wako!Pure!Chem.!! Japan! www.wako:chem.co.jp!! x'' '

! ! !!


'

'

Table'4:'Companies'Listed'by'Geographical'Location'or'Sales'Regions'Co

mpa

ny!

Head

quarters!

Web

site!

Globa

l!

North!America!

Europe

!

Asia!

South!Am

erica!

Afric

a!

Australia!

AB!Enzymes! Germany! www.abenzymes.com!! x'' ' ' ' ' '

AB!Vista! UK! www.abvista.com!! x'' ' ' ' ' '

Acore!Pharmatech! USA! www.acorePharmatech.com!!'

x'' ' ' ' '

Actygea! Italy! www.actygea.com!!' '

x'' ' ' '

Addiseo! France! www.adisseo.com!! x'' ' ' ' ' '

Advanced!Enzyme!Technologies,!Ltd.! India! www.advancedenzymes.com!!

x'' ' ' ' ' '

Agrimex! Belgium! www.agrimex.be!!' '

x'' ' ' '

Ajinomoto! Japan! www.ajinomoto.com!! x'' ' ' ' ' '

Aldevron! USA! www.aldevron.com!! x'' ' ' ' ' '

Alea!Evolution! Italy! www.alea:evolution.com!!'

x'' ' ' ' '

Alfa!Kimya!Company! Turkey! www.en.alfakimya.com!!!' '

x'' ' ' '

AlfaNzyme!Bio:Tech! India! www.alfanzymebiotech.com!!' ' '

x'' ' '

Alliance!Enzyme!Pvt!Ltd! India! www.papainenzyme.com!!' ' '

x'' ' '

Alltech!USA! USA! www.alltech.com!! x'' ' ' ' ' '

Almac!Sciences! UK! www.almacgroup.com!! x'' ' ' ' ' '

Alpha!Diagnostic!International! USA! www.4adi.com!!

x'' ' ' ' ' '

! ! !!


Table'4:'Companies'Listed'by'Geographical'Location'or'Sales'Regions'

Compa

ny!

Head

quarters!

Web

site!

Globa

l!

North!America!

Europe

!

Asia!

South!Am

erica!

Afric

a!

Australia!

Amano!Enzyme!Co.!Ltd.! Japan! www.amano:enzyme.co.jp!! x'' ' ' ' ' '

American!Biosystems! USA!www.americanbiosystems.com!! '

x'' ' ' ' '

American!Laboratories,!Inc! USA!

www.americanlaboratories.com!! '

x'' ' ' ' '

Americos!Industries!Inc! India! www.kenencoregroup.com!!' ' '

x'' ' '

Amit!Biotech!Pvt.!Ltd.! India! www.amitbiotech.com!!' ' '

x'' ' '

AMPLICON!Czech!Republic!

www.amplicon.cz!!' '

x'' ' ' '

Ampliqon!A/S! Denmark! www.ampliqon.com!! x'' ' ' ' ' '

ANC!Enzymes! Singapore! www.ancenzymes.com!!' ' '

x'' ' '

Andrés!Pintaluba,!S.A.!!!!! Spain! www.pintaluba.com!! x'' ' ' ' ' '

Anil!Bioplus! India! www.anilbioplus.com!! x'' ' ' ' ' '

Anthem!Cellutions! India! www.anthemcell.com!!' ' '

x'' ' '

Apollo!Chemical!Company! USA! www.apollochemical.com!! '

x'' ' ' ' '

Apollo!Scientific! UK! www.apolloscientific.co.uk!! x'' ' ' ' ' '

Applied!Biotechnology!Institute! USA! www.appliedbiotech.org!! '

x'' ' ' ' '

Archaenzyme!Ltd! Israel! www.archaezyme.com!!' ' '

x'' ' '

ArcticZymes! Norway! www.arcticzymes.com!!! x'' ' ' ' ' '

Ares!Bioscience!GmbH!Germany! www.genecraft.de!! x'

' ' ' ' ' '

! ! !!



Compa

ny!

Head

quarters!

Web

site!

Globa

l!

North!America!

Europe

!

Asia!

South!Am

erica!

Afric

a!

Australia!

(Genecraft)!

Arun!and!Co! India! www.arunandco.com!!' ' '

x'' ' '

ASA!Spezialenzyme!GmbH! Germany! www.asa:enzyme.de!! ' '

x'' ' ' '

Asahi!Kasei!Pharma! Japan! www.asahi:kasei.com!! x'' ' ' ' ' '

AUMEnzymes! India! www.aumenzymes.com!!' ' '

x'' ' '

Aumgene! India! www.aumgene.com!!' ' '

x'' ' '

BASF!! Germany! www.basf.com!! x'' ' ' ' ' '

BBI!Enzymes! UK! www.bbienzymes.com!! x'' ' ' ' ' '

BehnMeyer! Germany! www.behnmeyer.com!! x'' ' ' ' ' '

Beldem! Belgium! www.beldem.com!! x'' ' ' ' ' '

Berg!+!Schmidt!GmbH!&!Co.!KG! Germany! www.berg:schmidt.de!!

x'' ' ' ' ' '

Bergerow! Germany! www.begerow.com!! x'' ' ' ' ' '

Berlin!Chemical! China! www.berlinchem.com!!' ' '

x'' ' '

BiCT!srl! Italy! www.bict.it!!' '

x'' ' ' '

BIO:CAT! USA! www.bio:cat.com!!'

x'' ' ' ' '

Biocat!Collection! Germany! www.biocatcollection.net!!' '

x'' ' ' '

Biocatalysts!Ltd.! UK! www.biocatalysts.com!!! x'' ' ' ' ' '

Biochem! Germany! www.biochem.net!!' '

x' x'' ' '

! ! !!



Compa

ny!

Head

quarters!

Web

site!

Globa

l!

North!America!

Europe

!

Asia!

South!Am

erica!

Afric

a!

Australia!

Biomin! Austria! www.biomin.net!! x'' ' ' ' ' '

BIO:PORT!Europe!s.r.o.!Czech!Republic! www.bio:port.cz!!! ' '

x'' ' ' '

BioPox! Italy! www.biopox.com!!' '

x'' ' ' '

Biorbyt!Ltd.!! UK! www.biorbyt.com!! x'' ' ' ' ' '

BioResearch!Products! USA! www.bio:researchprod.com!!'

x'' ' ' ' '

Bioron!GmbH! Germany! www.bioron.net!! x'' ' ' ' ' '

Bioseutica! Netherlands!www.bioseutica.com!! x'' ' ' ' ' '

BioSphere! Italy! www.biospheresrl.com!! x'' ' ' ' ' '

biovet! Bulgaria! www.biovet.com!! x'' ' ' ' ' '

Biozym! Germany! www.biozym.com!!!!' '

x'' ' ' '

BioZyme! Romania! www.biozyme.ro!!!' '

x'' ' ' '

BRAIN!AG! Germany! www.brain:biotech.de!! x'' ' ' ' ' '

Brenntag! Germany! www.brenntag.com!! x'' ' ' ' ' '

BSC!Biochemicals! Belgium! www.bscbio.be!!' '

x'' ' ' '

C.Schliessmann! Germany! www.c:schliessmann.de!!' '

x'' ' ' '

C5.6!Technologies! USA! www.c56technologies.com!!!'

x'' ' ' ' '

Calzyme! USA! www.calzyme.com!! x'' ' ' ' ' '

Cambrex!IEP!GmbH! USA! www.cambrex.com!! x'' ' ' ' ' '

Cellectis!SA! France! www.cellectis.com!! x'' ' ' ' ' '

! ! !!



Compa

ny!

Head

quarters!

Web

site!

Globa

l!

North!America!

Europe

!

Asia!

South!Am

erica!

Afric

a!

Australia!

Centerchem! USA! www.centerchem.com!! x'' ' ' ' ' '

Chematics! USA! www.chematics.com!!'

x'' ' ' ' '

CHEMOS!GmbH! Germany! www.chemos:group.com!!' '

x'' ' ' '

Chimab! Italy! www.chimab.it!!' '

x'' ' ' '

Chiral!Vision! Netherlands!www.chiralvision.com!! x'' ' ' ' ' '

Chr.!Hansen! Denmark! www.chr:hansen.com!! x'' ' ' ' ' '

CHT/BEZEMA! Germany! www.cht:group.com!! x'' ' ' ' ' '

CLEA!Technologies! Netherlands!www.cleatechnologies.com!! x'' ' ' ' ' '

c:LEcta!GmbH! Germany! www.c:lecta.com!! x'' ' ' ' ' '

Codexis,!Inc.! USA! www.codexis.com!! x'' ' ' ' ' '

Colotex!Company!Ltd! Hong!Kong! www.colotexbiotech.com!!' ' '

x'' ' '

Concord!Biotech! India! www.concordbiotech.com!! x'' ' ' ' ' '

Condor!Specialty!Products! USA! www.condorspecialty.com!! '

x'' ' ' ' '

CPC!Biotech! Italy! www.cpcbiotech.it!! x'' ' ' ' ' '

Creative!BioMart! USA! www.creativebiomart.net!! x'' ' ' ' ' '

Deltagen!Bioproducts!N.A.!

Netherlands!Antilles! www.deltagenbiop.com!!! ' ' ' '

x'' '

Direvo!Industrial!Biotechnology!GmbH! Germany! www.direvo.com!!

x'' ' ' ' ' '

Discovery!Biocatalysts! UK! www.discovery:bc.co.uk!! x'' ' ' ' ' '

! ! !!



Compa

ny!

Head

quarters!

Web

site!

Globa

l!

North!America!

Europe

!

Asia!

South!Am

erica!

Afric

a!

Australia!

DNA!Polymerase!Technology!Inc.! USA! www.klentaq.com!! '

x'' ' ' ' '

Dong!Nam!Chemicals!&!Equipments!Corporation!Vietnam! www.dongnamlab.com!! ' ' '

x'' ' '

DSM! Netherlands!www.dsm.com!! x'' ' ' ' ' '

DuPont!(Danisco:Genencor)! USA! www.dupont.com!!

x'' ' ' ' ' '

Dyadic! USA! www.dyadic.com!!! x'' ' ' ' ' '

DyStar! Germany! www.dystar.com!! x'' ' ' ' ' '

Elanco!(Chem!Gen)! USA! www.elanco.us!! x'' ' ' ' ' '

elementalenzymes! USA! www.elementalenzymes.com!!'

x'' ' ' ' '

EMELCA!Bioscience! Belgium! www.emelcabio.com!!!!' '

x'' ' ' '

Emp!Biotech!GmbH! Germany! www.empbiotech.com!!' '

x'' ' ' '

Enantis!Czech!Republic! www.enantis.com!! ' '

x'' ' ' '

Enartis!Vinquiry! Italy! www.enartis.com!! x'' ' ' ' ' '

Engrain! USA! www.engrain.us!!'

x'' ' ' ' '

ENGroup! China! www.engroup.cn!!' ' '

x'' ' '

EnMex!SA!DE!CV! Mexico! www.enzymes.com.mx!!'

x'' ' ' ' '

Enzagen! UK! www.enzagen.com! ' ' x' ' ' ' '

Enzybel!International! Belgium! www.enzybel.com!! x'' ' ' ' ' '

! ! !!



Compa

ny!

Head

quarters!

Web

site!

Globa

l!

North!America!

Europe

!

Asia!

South!Am

erica!

Afric

a!

Australia!

Enzymatic!Deinking!Technologies,!LLC! USA! www.edt:enzymes.com!! '

x'' ' ' ' '

Enzymatics! USA! www.enzymatics.com!!'

x'' ' ' ' '

Enzyme!Development!Corporation! USA!

www.EnzymeDevelopment.com!! '

x'' ' ' ' '

Enzyme!Solutions! Australia!www.enzymesolutions.com.au!! ' ' ' ' ' '

x'

Enzyme!Solutions!(USA)! USA! www.enzymesolutions.com!!'

x'' ' ' ' '

Enzyme!Supplies! UK! www.enzymesupplies.com!!' '

x'' ' ' '

EnzymeKing!Biotechnology!Co.!Ltd! China! www.enzymeking.com!! ' ' '

x'' ' '

Enzymes!Naveen! India! !!' ' '

x'' ' '

EnzymeWorks! China! www.enzymeworking.com!!' ' '

x'' ' '

Enzymicals!AG! Germany! www.enzymicals.com!!!' '

x'' ' ' '

Enzymology!Research!Center!Inc! USA! www.ercenzymes.com!! '

x'' ' ' ' '

Enzyvia!LLC! USA! www.enzyvia.com!!'

x'' ' ' ' '

epicentre! USA! www.epibio.com!! x'' ' ' ' ' '

epygen! UAE! www.epygen.com!! x'' ' ' ' ' '

ERA!Biotech! Spain! www.erabiotech.com!!' '

x'' ' ' '

Erbsloh!Geisenheim!AG! Germany! www.erbsloeh.com!! x'' ' ' ' ' '

Eucodis!Biosciences!Austria! www.eucodis.com!! x'

' ' ' ' ' '

! ! !!



Compa

ny!

Head

quarters!

Web

site!

Globa

l!

North!America!

Europe

!

Asia!

South!Am

erica!

Afric

a!

Australia!

GmbH!

Evocatal!GmbH! Germany! www.evocatal.com!! x'' ' ' ' ' '

Fenkin!Kimya!Sanayi!Ve!Ticaret!Ltd! Turkey! www.fenkim.com!! ' '

x'' ' ' '

Fermenta!Biotech!Ltd! India! www.fermentabiotech.com!! x'' ' ' ' ' '

Fermentia! Hungary! www.fermentia.eu!!' '

x'' ' ' '

Fytozimus! Canada! www.fytozimus.com!!'

x'' ' ' ' '

Galilaeus!Oy! Finland! www.galilaeus.fi!!' '

x'' ' ' '

Genkim! Turkey! www.genkim.com.tr!!' '

x'' ' ' '

GenScript!USA!Inc! USA! www.genscript.com!! x'' ' ' ' ' '

GNCBioferm! Canada! www.gncbioferm.ca!! x'' ' ' ' ' '

Habio!Bioengineering! China! www.habio.net!! x'' '

x'' ' '

Huvepharma! Bulgaria! www.huvepharma.com!! x'' ' ' ' ' '

IBEX! Canada! www.ibex.ca!! x'' ' ' ' ' '

Imperial!Jade!Bio:Technology!Co.,!Ltd.! China!

www.imperialjade12.en.china.cn!!! ' ' '

x'' ' '

Infinite!Enymzes! USA! www.infiniteenzymes.com!!!'

x'' ' ' ' '

InnoTech!MSU! Russia! www.innotech:msu.com!!' '

x'' ' ' '

Iris!Biotech!GmbH! Germany! www.iris:biotech.de!!' '

x'' ' ' '

Jena!Bioscience!GmbH! Germany! www.jenabioscience.com!! x'' ' ' ' ' '

! ! !!



Compa

ny!

Head

quarters!

Web

site!

Globa

l!

North!America!

Europe

!

Asia!

South!Am

erica!

Afric

a!

Australia!

Jiangsu!Boli!Bioproducts!Co.!Ltd! China! www.bolibio.com!! ' ' '

x'' ' '

Jiangsu!OGO!Biotech!Co.,!Ltd.! China! www.ogo:biotech.com!! ' ' '

x'' ' '

Jinan!Tiantianxiang!Co.,!Ltd.! China! www.jnttx.com!! ' ' '

x'' ' '

Johnson!Matthey! UK! www.jmcct.com!! x'' ' ' ' ' '

Kemikalia! Sweden! www.kemikalia.se!!' '

x'' ' ' '

Kemin! USA! www.kemin.com!! x'' ' ' ' ' '

Kerry!Americas! USA! www.kerry.com!! x'' ' ' ' ' '

Kiotechagil! UK! www.kiotechagil.com!! x'' ' ' ' ' '

Kiwienzyme.com!Ltd!New!Zealand! www.kiwienzyme.com!! ' ' ' ' ' '

x'

Lactosan!GmbH! Austria! www.lactosan.at!! x'' ' ' ' ' '

Laffort! France! www.laffort.com!! x'' ' ' ' ' '

Lallemand! Canada! www.lallemand.com!! x'' ' ' ' ' '

Lamothe:Abiet! France! www.lamothe:abiet.com!! x'' ' ' ' ' '

Lanxess! Germany! www.lanxess.com!!!!! x'' ' ' ' ' '

Larbus!s.a.! Spain! www.larbus.com!!' '

x'' ' ' '


Czech!Republic! www.lentikats.eu!!

x'' ' ' ' ' '

Leveking!Enzymes! China! www.levekingenzymes.com!! x'' ' ' ' ' '

! ! !!



Compa

ny!

Head

quarters!

Web

site!

Globa

l!

North!America!

Europe

!

Asia!

South!Am

erica!

Afric

a!

Australia!

Libragen! France! www.libragen.com!! x'' ' ' ' ' '

Life!Technologies!(GeneArt)! USA! www.lifetechnologies.com!!

x'' ' ' ' ' '

Lonza! Switzerland! www.lonza.com!! x'' ' ' ' ' '

Lucigen! USA! lucigen.com!! x'' ' ' ' ' '

Lumis!Biotech! Inda! www.lumisbiotech.com!!' ' '

x'' ' '

Lybradyn! USA! www.lybradyn.com!!'

x'' ' ' ' '

Lyven! France! www.lyven.com!!' '

x'' ' ' '

M!L!CHEMICALS!(INDIA)!PVT!LTD.! India! www.mlindia.com!! ' ' '

x'' ' '

Maps!Enzyme!Limited! India! www.mapsenzymes.com!! x'' ' ' ' ' '

Megazyme!Ireland! Ireland! www.megazyme.com!! x'' ' ' ' ' '

Meito!Sangyo! Japan!www5.mediagalaxy.co.jp/meito/kaseihin/index_e.html!!

x'' ' ' ' ' '

Menlo!Biotech/Ecozymes! UK! www.menlobiotech.com!!! ' ' ' ' '

x''

Merck!KGaA!(EMD!Millipore,!Calbiochem)! Germany! www.emdgroup.com!!

x'' ' ' ' ' '

Metabomics! China! www.metabomics.com!!' ' '

x'' ' '

Metgen!Oy! Finland! www.metgen.fi!! x'' ' ' ' ' '

Millbo! Italy! www.millbo.com!! x'' ' ' ' ' '

Mirpain! Turkey! www.mirpain.com!! x'' ' ' ' ' '

! ! !!



Compa

ny!

Head

quarters!

Web

site!

Globa

l!

North!America!

Europe

!

Asia!

South!Am

erica!

Afric

a!

Australia!

Mühlenchemie! Germany! www.muehlenchemie.de!! x'' ' ' ' ' '

MP!Biomedical! USA! www.mpbio.com!! x'' ' ' ' ' '

Nagase! Japan! www.nagasechemtex.co.jp!!' ' '

x'' ' '

Najing!Chemlin!Chemical!Industry! China!

www.chemlin.guidechem.com!!! ' ' '

x'' ' '

NEB! USA! www.neb.com!! x'' ' ' ' ' '

Nordmann,!Rassmann! Germany!www.nordmann:rassmann.com!!

x'' ' ' ' ' '

Novozymes! Denmark! www.novozymes.com!! x'' ' ' ' ' '

Novus! USA! www.novusint.com!! x'' ' ' ' ' '

Nutreco! Netherlands!www.nutreco.com!!!! x'' ' ' ' ' '

Nzomics!Biocatalysis! UK! www.nzomics.com!!' '

x'' ' ' '

NZYTech! Portugal! www.nzytech.com!! x'' ' ' ' ' '

OenoBioTech!SAS! France! www.oenobiotech.com!!' '

x'' ' ' '

Oenobrands! France! www.oenobrands.com!! x'' ' ' ' ' '

OptiGene! UK! www.optigene.co.uk!! x'' ' ' ' ' '

ORBA! Turkey! www.orba.com.tr!!' '

x'' ' ' '

Oriental!Yeast! Japan! www.oyc.co.jp!! x'' ' ' ' ' '

Parchem! USA! www.parchem.com!!'

x'' ' ' ' '

Prochimica!Group! Italy! www.prochimicagroup.com!!' '

x'' ' ' '

! ! !!



Compa

ny!

Head

quarters!

Web

site!

Globa

l!

North!America!

Europe

!

Asia!

South!Am

erica!

Afric

a!

Australia!

Proenzimas!Ltda! Columbia! www.proenzimas.com!!' ' ' '

x'' '

Promega! USA! www.promega.com!! x'' ' ' ' ' '

Protean!Czech!Republic! http://www.protean.cz! ' '

x'' ' ' '

Proteogen!Bio! Italy! www.proteogenbio.com!!' '

x'' ' ' '

Prozomix! UK! www.prozomix.com!!' '

x'' ' ' '

Prozyme! USA! www.prozyme.com!!'

x'' ' ' ' '

Purolite! USA! www.purolite.com!!! x'' ' ' ' ' '

Research!Products!Company! USA! www.researchprod.com!!! '

x'' ' ' ' '

Roal!Oy! Finland! www.roal.fi!!' '

x'' ' ' '

RobinsonBioproducts! Canada!www.robinsonbioproducts.com!! '

x'' ' ' ' '

Roche! Switzerland! www.roche.com!! x'' ' ' ' ' '

Rossari!Biotech! India! www.rossari.com!!' ' '

x'' ' '

S!I!CHEMICAL!INDUSTRIES! India! www.papain.in!! ' ' '

x'' ' '

Sartoris!Stedim!Biotech! France! www.sartorius:stedim.com!! x'' ' ' ' ' '

Scott!Laboratories! USA! www.scottlab.com!!'

x'' ' ' ' '

Season!Chemicals!Dyestuffs! Hong!Kong! www.sesaonchemicals.com!! ' ' '

x'' ' '

Sekisui!Enzymes! UK! www.sekisuienzymes.com!! x'' ' ' ' ' '

! ! !!



Compa

ny!

Head

quarters!

Web

site!

Globa

l!

North!America!

Europe

!

Asia!

South!Am

erica!

Afric

a!

Australia!

Senson!Ltd! Finland! www.senson.fi!!' '

x'' ' ' '

Shandong!Longda!Bio:Products!Co.,!Ltd.! China! www.enzymeinchina.com!! ' ' '

x'' ' '

SHIN!NIHON!CHEMICAL!CO.,!LTD.! Japan!

www.aichi:brand.jp/corporate/type/chemical/shin:nihon:e.html!!

x'' ' ' ' ' '

SibEnzyme! Russia! www.sibenzyme.com!! x'' ' ' ' ' '

Sigma:Aldrich! USA! www.sigmaaldrich.com!! x'' ' ' ' ' '

SinoBios!! China! www.sinobios.com!!' ' '

x'' ' '

Specialty!Enzymes!and!Biotechnologies!Inc.! USA! www.specialtyenzymes.com!! '

x'' ' ' ' '

SpheriTech!Ltd.! UK! www.spheritech.com!!!' '

x'' ' ' '

Sprin! Italy! www.sprintechnologies.com!!' '

x'' ' ' '

SternEnzym! Germany! www.sternenzym.de!!' '

x'' ' ' '

Strem! USA! www.strem.com!! x'' ' ' ' ' '

Sukahan! China! www.sukahan.com!!' ' '

x'' ' '

Sunson!Industry!Group!Company!Limited! China! www.chinaenzymes.com!!

x'' ' ' ' ' '

SynBioCat!Ltd! Hungary! www.synbiocat.hu!!' '

x'' ' ' '

Syncozymes! China! www.syncozymes.com!!' ' '

x'' ' '

Takabio! France! www.takabio.com!!' '

x'' ' ' '

tebu:bio! France! www.tebu:bio.com!!' '

x'' ' ' '

! ! !!



Compa

ny!

Head

quarters!

Web

site!

Globa

l!

North!America!

Europe

!

Asia!

South!Am

erica!

Afric

a!

Australia!

Tegaferm! Austria! www.tegaferm.com!!' '

x'' ' ' '

Tex!Biosciences! India! www.texbiosciences.com!!' ' '

x'' ' '

The!Seydel!Companies! USA! www.seydel.com!!'

x'' ' ' ' '

ThermoFisher! USA! www.thermoscientific.com!! x'' ' ' ' ' '

Toyobo!Enzymes! Japan! www.toyobo:global.com!! x'' ' ' ' ' '

TransBiodiesel! Israel! www.transbiodiesel.com!!' ' '

x'' ' '

Tri:Tex!Co! Canada! www.tritex.com!!'

x'' ' ' ' '

Ultra!Bio:Logics!Inc.! Canada! www.ublcorp.com!! x'' ' ' ' ' '

Unikbio!Biotech(Guangzhou)!Ltd! China! www.unikbio.com!! ' ' '

x'' ' '

Unitaka! Japan! www.unitika.co.jp!! x'' ' ' ' ' '

VEMO!99!Ltd!! Bulgaria! www.vemo:vsv.com!!' '

x'' ' ' '

Verenium! USA! www.verenium.com!! x'' ' ' ' ' '

Veskim! Turkey!! www.veskim.com!!' '

x'' ' ' '

W42!Industrial!Biotechnology!GmbH! Germany! www.w42biotechnology.de!! ' '

x'' ' ' '

Wako!Pure!Chemical!Industries! Japan! www.wako:chem.co.jp!!

x'' ' ' ' ' '

Weiss!Biotech!GmbH! Germany! www.weissbiotech.com!!' '

x'' ' ' '

Worthington! USA!www.worthington:biochem.com!!

x'' ' ' ' ' '

! ! !!



Compa

ny!

Head

quarters!

Web

site!

Globa

l!

North!America!

Europe

!

Asia!

South!Am

erica!

Afric

a!

Australia!

Yakult! Japan! www.yakult.co.jp/ypi/en/!! x'' ' ' ' ' '

Zymetech! Iceland! www.zymetech.com!! x'' ' ' ' ' '

Zytex! India! www.zytex.com!! x'' ' ' ' ' '

'' '

! ! !!


AB'Enzymes'GmbH'

http://www.abenzymes.com/!!

Feldbergstrasse!78!

64293!Darmstadt!

Germany!

Tel:!+49!(0)!61!51:36!80:100!|!Fax:!+49!(0)!61!51:36!80:120!

Email:[email protected]!

Year!Founded! 1907!Size!($!or!employee!count!or!both)!

201:500!employees!

Company!type! Subsidiary!of!public!company:!Associated!British!Foods!plc,!ticker!ABF!Enzyme!sales!absolute!and/or!as!a!percentage!of!company!sales!

Enzymes!sales!are!grouped!together!with!other!ingredients,!and!the!total!for!all!such!sales!in!2012!was!about!£1!billion,!or!$1.6!billion.!

Enzyme!markets! Textiles,!paper!and!pulp,!detergents,!baking,!food,!animal!feed,!biofuels,!brewing,!and!winemaking.!

Expression!systems! Trichoderma,,Aspergillus,,Bacillus,,and,other,standard,hosts!Capacity/scale! Multi:ton.!!In:house!production!Key!People! Aryan!Moelker,!CEO;!Karl:Heinz!Maurer,!Director!of!Business!Development!Partnerships! Distributes!in!part!through!Barentz,!partnered!with!Genedata!for!strain!

engineering,!distributes!enzymes!for!Finnish!enzyme!company!Roal!Oy.!!Roal!Oy!is!a!joint!venture!of!Associated!British!Foods!plc!and!Altia.!

Customers! Extensive,!global!Financial!Health! +++!(profitable!company!generating!dividends!for!shareholders)!Catalog!of!Enzymes! +++!!Toll!Manufacturing! :!!

AB!Enzymes!is!a!subsidiary!of!ABF!Ingredients,!which!is!in!turn!a!subsidiary!of!Associated!British!Foods!plc,!and!has!its!origins!in!1907!when!Röhm!and!Haas!was!founded.!!The!company!sells!industrial!enzymes!worldwide!and!has!offices!in!several!countries.!!The!company!engineers!both!enzymes!and!production!strains,!and!has!manufacturing!plants!in!multiple!countries.!

Products:!

Amylases!

Xylanases!

Transglutaminases!

! ! !!


Proteases!

Lipases!

Cellulases!

Pectinases!

Arabinases!

Beta:glucanases!

Papain!

Phytase!

Phospholipase!

Mannanase!

Catalase!

!

!

!

' '

! ! !!


A.B.'Vista'

www.abvista.com!!

Woodstock!Court!

Blenheim!Road!

Marlborough!Business!Park!

Marlborough!

Wiltshire!

SN8!4AN!

UK!

Tel:!+44(0)1672!517!650!

[email protected]!


51:200!employees!

Company!type! Part!of!Associated!British!Foods!Enzyme!sales!absolute!and/or!as!a!percentage!of!company!sales!

Significant!portion!

Enzyme!categories! Animal!feed.!Expression!systems! Trichoderma,,Aspergillus,,Bacillus,,and!other!standard!hosts!via!AB!Enzymes,,Capacity/scale! Bulk.!!Done!in:house!by!parent!company!AB!Enzymes.!Key!People! Richard!Cooper,!Managing!Director!Partnerships! AB!Vista!is!the!distributor!of!feed!enzymes!for!AB!Enzymes!GmbH,!the!sole!

distributor!of!Roal!Oy.!Both!AB!Vista!and!AB!Enzymes!are!part!of!the!Associated!British!Food!plc!(ABF)!group.!Roal!has!the!brand!expertise,!R&D!expertise!and!production!technology!to!produce!a!range!of!enzyme!products!for!the!feed!industry.!AB!Vista!provides!supplementary!marketing!and!technical!support!for!the!feed!market,!along!with!the!sales,!logistics!and!customer!service!support!to!optimise!its!feed!enzyme!offering.!

Customers! Global!Financial!Health! +++!Catalog!of!Enzymes! +!Toll!Manufacturing! :!!

AB!Vista!is!focused!on!animal!nutrition!enzymes.!

Products:!Phytases,!Xylanases' !

! ! !!


Acore'Pharmatech!

www.acorePharmatech.com!!

29!Tennyson!Dr.!

Plainsboro,NJ!08536!

USA!

Tel:!+1:609:755:4073!

Fax:!+1:609:755:0590!

Email:[email protected]!!

Year!Founded! 2008!(as!Syncore!Labs,!now!Syncozymes)!Size!($!or!employee!count!or!both)!

About!$5:10!million!annually!(Syncozymes),!11:50!employees!

Company!type! Private!Enzyme!sales!absolute!and/or!as!a!percentage!of!company!sales!

The!company!offers!both!enzymes!and!chemical!intermediates.!

Enzyme!categories! Biocatalysis,!diagnostics.!Expression!systems! NA;!see!Syncozymes!Capacity/scale! Syncozymes’!fermentation!capabilities!include!fermenters!of!greater!than!

100!L!capacity,!and!the!company!offers!enzyme/chiral!products!on!a!100!kg!scale!with!a!3:4!month!lead!time.!!!

Key!People! James!Wen!is!listed!as!Founder!and!CEO!in!his!LinkedIn!profile!Partnerships! Acore!is!the!US!division!of!the!Chinese!company!Syncozymes!Customers! Pharmaceutical!and!chemical!companies!for!biocatalysis!applications!Financial!Health! +!(a!CRO/CMO,!which!has!experienced!uneven!revenues!year!to!year)!Catalog!of!Enzymes! +++!(extensive)!Toll!Manufacturing! +!(small!scale)!!

Acore!is!the!US!business!office!and!distributor!for!Syncozymes.!!Syncozymes!in!turn!is!the!current!name!for!the!company!founded!in!2008!as!Syncore!Labs!in!Shanghai!China.!!Acore!distributes!enzymes!and!chemical!intermeidates!developed!in!and!shipped!from!Syncozymes.!!Therefore,!all!data!above!are!indicative!of!Syncozymes,!the!parent!company.!!For!more!information,!see!the!entry!for!Syncozymes.!!

Products:!

The!catalog!from!SYncozymes!includes!hundreds!of!enzymes!in!many!enzyme!classes!including!the!following!in!both!individual!enzyme!and!enzyme!kit!format:!!

Ene!reductases!!

! ! !!


Ketoreductases!

Transaminases!

Lipases!

Proteases!

Amidases!

Nitrilases!

Nitro!reductases!

Alcohol!oxidases!

Glycosidases!

Nitrile!hydratases!

Cytochrome!P450s!

Aldolases!

Cofactor!regeneration!enzymes!

Amino!acid!dehydrogenases!

Glucose!dehydrogenase!

Glucose:6:phosphate!dehydrogenase!

3a:hydroxysteroid!dehydrogenase!

Bilirubin!oxidase!

Uricase!

Ascorbate!oxidase!

Peroxidase!

Xanthine!oxidase!

Glutamate!dehydrogenase!

Glycerol!kinase!

Pyruvate!kinase!

! ! !!


Urease!

Adenosine!deaminase! !

! ! !!


Actygea'

http://www.actygea.com/!!

Insubrias!BioPark!

via!R.!Lepetit!34!

21040!Gerenzano!(VA)!!

Italy!

Tel:!!+39!02!96474!1!

Fax:!+39!02!96474!500!



Very!small!


None!

Enzyme!categories! NA!Expression!systems! Proprietary!strains,!bacteria,!fungi!Capacity/scale! One!2000!L!fermenter,!two!200!L!fermenters,!one!!50!L!fermenter,!one!30!L!

fermenter!and!many!other!smaller!vessels!Key!People! Fabrizio!Beltrametti,!CEO!and!Co:Founder!Partnerships! NA!Customers! NA!Financial!Health! NA!Catalog!of!Enzymes! :!Toll!Manufacturing! +!!

Actygea!S.r.l.,!specializes!in!novel!organisms,!strains,!and!contract!fermentation,!as!well!as!downstream!processing!and!purification!of!those!products.!!The!company!seeks!to!produce!enzymes!and!other!products!on!a!contract!basis.!!Actygea!is!taking!part!in!a!European!grant!called!MetaExplore!to!identify!novel!enzymes.!

!

!

' '

! ! !!


Adisseo'

http://www.adisseo.com/!!

Immeuble!Antony!Parc!2!

10,!Place!du!Général!de!Gaulle!

92160!Antony!

France!

Tel:!+33!(0)1!46!74!70!00!


1700!employees!including!parent!

Company!type! Adisseo!Group!is!one!of!the!main!subsidiaries!of!China!National!BlueStar,!a!key!player!in!the!chemical!industry!in!China!with!30,478!staff!and!a!turnover!of!6.9!billion!euros.!

Enzyme!sales!absolute!and/or!as!a!percentage!of!company!sales!


Enzyme!categories! Animal!feed!!Expression!systems! A!non:genetically!modified!strain!of!Penicillium,funiculosu,!and!

Schizosaccharomyces,pombe!Capacity/scale! Bulk.!!In:house!production!likely.!Key!People! NA!Partnerships! NA!Customers! Global.!Financial!Health! +++!Catalog!of!Enzymes! ++!Toll!Manufacturing! :!!

Adisseo!is!an!animal!nutrition!company.!

Products:!

Xylanases!

Phytases!

Beta:glucanases!

' '

! ! !!


Advanced'Enzyme'Technologies'Ltd.'

http://www.advancedenzymes.com/!!

Corporate!Office!

5th!Floor,!'A'!wing,!Sun!Magnetica!

LIC!Service!Road,!Louiswadi!

Thane!(W)!400!604!

India!

Tel:!+91:22:4170!3200!

Fax:!+!91:22:25835159!



33!million!USD!in!2012,!201:500!employees.!

Company!type! Expected!to!go!public!soon!Enzyme!sales!absolute!and/or!as!a!percentage!of!company!sales!

100%!of!sales!from!enzymes!and!formulated!enzyme!–based!products.!

Enzyme!categories! Biocatalysis,!leather,!textiles,!pharmaceutical,!animal!feed,!food,!paper,!biofuels.!

Expression!systems! Mostly!natural!hosts!in!plants,!bacteria,!animals,!and!fungi!Capacity/scale! More!than!500!MT!per!month!in!enzyme!concentrate,!four!total!plants.!!In:

house!production.!Key!People! Run!by!Chandrakant!L.!Rathi,!CEO!and!Vasant!L.!Rathi,!Chairman!Partnerships! Specialty!Enzymes!and!Biotechnologies!in!the!US!is!a!subsidiary!Customers! More!than!700!customers!across!45!countries!worldwide!Financial!Health! +++!(profitable,!dividend!payer)!Catalog!of!Enzymes! +++!(55+!enzymes,!extensive!offerings)!Toll!Manufacturing! :!!

Advanced!Enzymes!is!a!large!and!growing!enzyme!manufacturing!company!with!a!long!history!in!India.!!The!first!product!was!papain,!extracted!from!locally:grown!papayas.!Now!Advanced!Enzymes!operate!4!manufacturing!plants,!with!offices!in!countries!around!the!world,!and!a!major!subsidiary!in!the!USA!(Specialty!Enzymes!and!Biotechnologies).!!The!company!filed!for!an!IPO!in!India!in!2013,!and!expects!to!raise!money!to!expand!manufacturing!capacity.!!Advanced!Enzymes!is!the!second!largest!enzyme!seller!in!India!behind!Novozymes,!and!the!company!sells!53%!of!their!products!in!Europe!and!the!United!States.!!

! ! !!


Products:!

Serropeptidase!

Lipases:!CAL:B!(soluble!and!immobilized);!Aspergillus!niger;!Lipase!TL!(Thermomyces!lanuginosus);!Rhizopus!delemar;!Candida!rugosa!

Proteases:!papain;!bromelain;!!

Peptidases:!Serrariopeptidase;!Endo!Proline!Peptidase;!Leuicine!Amino!Peptidase!Exo;!Exo!Proline!Peptidase!!Ferulic!acid!esterase!!Lactase!!Nattokinase!

Alpha:galactosidase!

Beta:glucosidase!

Beta:xylosidase!

Beta:mannosidase!(Mannanase)!

Cellulase!

Hemicellulase!(xylanase)!

Amylases!(Alpha:amylase,!glucoamylase)!

Beta:glucanases!

Xylo:oligosidase!

Manno:oligosidase!

Pectinase!

Phytase!

Phospholipase!

Glucose!oxidase!

Tannase!

Catalase!

! ! !!


Agrimex'NV'

http://www.agrimex.be/!!

Achterstenhoek!5!

2275!Lille!

Belgium!

Tel:!+32!14!88!22!11!

Fax:!+32!14!88!33!40!


11:50!

Company!type! Private,!owned!by!the!Kuge!Invest!Group,!a!Belgian!holding!company.!Enzyme!sales!absolute!and/or!as!a!percentage!of!company!sales!

Small!

Enzyme!categories! Animal!feed!Expression!systems! NA!Capacity/scale! Bulk.!!No!in:house!production.!Key!People! NA!Partnerships! Distributes!for!Beldem.!Customers! NA!Financial!Health! NA!Catalog!of!Enzymes! +!Toll!Manufacturing! :!!

From!the!website:!“Agrimex!is!specialized!in!the!development,!production!and!marketing!of!specialty!products!for!the!feed!industry.!Besides!sales!and!marketing!of!its!own!products!throughout!Europe,!Agrimex!is!the!exclusive!distributor!in!the!Benelux!market!for!a!number!of!reputable!manufacturers!of!high!quality!feed!ingredients!and!raw!materials.”!

Products:!

Xylanase!

!

' '

! ! !!


Ajinomoto'

www.ajinomoto.com/en/!!

15:1,!Kyobashi!1:chome!

Chuo:ku,!Tokyo!104:8315!

Japan!

Tel:!+81!3!5250!8111!


27,000!employees!

Company!type! Public!Enzyme!sales!absolute!and/or!as!a!percentage!of!company!sales!

Less!than!1%!

Enzyme!categories! Food!ingredients,!meat!tenderizing.!Expression!systems! NA!Capacity/scale! Bulk.!!In:house!production,!particularly!for!amino!acids!for!animal!feed!and!

food!Key!People! Masatoshi!Ito,!CEO!Partnerships! Torray!for!biobased!nylon;!OmniChem!subsidiary!for!manufacture!of!

pharmaceutical!fine!chemicals!Customers! Global!Financial!Health! +++!Catalog!of!Enzymes! +!Toll!Manufacturing! :!!

From!the!website:!“Ajinomoto!Co.,!Inc.!is!the!Tokyo:based!food,!beverage,!and!amino!acid!powerhouse!that!is!one!of!East!Asia’s!best:known!and!most!respected!brands,!with!annual!sales!of!US$10!billion!worldwide.!Manufacturing!and!marketing!a!diverse!range!of!products!around!the!globe,!Ajinomoto!is!a!leading!producer!of!amino:acid!based!specialty!chemicals!:!humectants,!surfactants,!emollients,!and!functional!powders!for!the!cosmetics!and!toiletries!industries.”!

Products:!

Transglutaminase!(Brand!name!Activa®)!

!

!

' '

! ! !!


Aldevron'

www.aldevron.com!!

3233!15!Street!South!!

Fargo,!ND!58104!!

USA!

Tel:!+1:701:297:9256!

Tel:!+1+877:PURE:DNA!(787:3362)!

Fax:!+1:701:280:1642!



51:200!employees!


None!

Enzyme!categories! NA!Expression!systems! E.,coli,!Insect,!Mammalian!Capacity/scale! Scale!—!1!ml!to!240!L.!!In:house!production.!Key!People! Michael!Chambers,!CEO!and!Co:Founder!Partnerships! NA!Customers! USA,!Germany!Financial!Health! ++!(growing)!Catalog!of!Enzymes! :!Toll!Manufacturing! +!!

Aldevron!produces!DNA,!proteins,!and!antibodies!on!a!contract!research!and!development!and!contract!manufacturing!organization.!!!

!

!

!

' '

! ! !!


Alea'Evolution'

http://www.alea:evolution.com/!!

Via!S.!Pertini!n.!12!

40062!Molinella!(BO)!

Italy!

Tel:!+39!335!7668356!

Fax:!+39!051!0544133!

Email:!info@alea:evolution.com!!

Year!Founded! NA!Size!($!or!employee!count!or!both)!

NA!


Enzymes!are!about!25%!of!the!company’s!offerings,!which!include!tannins!and!other!additives,!yeasts,!and!bacteria.!

Enzyme!categories! Winemaking!!Expression!systems! NA!Capacity/scale! Bulk.!!No!in:house!production.!Key!People! GIanpaolo!Guinelli,!Sales!manager;!Enrico!Bortolini,!Technical!Manager;!

Stefano!Guinelli,!Director!and!Technical!Manager!Partnerships! Verenium!supplies!the!enzymes!that!the!company!sells.!Partners!include!

Lallemand!and!various!wine!companies!Customers! Lallemand,!DIversey,!Win!&!Tech!Pura,!Enotrading,!Exacta!Optech,!Enopoint!Financial!Health! NA!Catalog!of!Enzymes! +!(small!assortment)!Toll!Manufacturing! :!!

Alea!Evolution!primarily!supplies!materials!to!the!wine!industry!in!Italy.!

Products:!

Pectinases!

Lysozyme!

Hemicelluase!

Beta:glucosidase!

' '

! ! !!


Alfa'Kimya'

http://en.alfakimya.com/!!!

Merkez!Mah.!Dereboyu!Cad.!No:55!

34303!Halkalı,!Istanbul!

Turkey!

Tel:!+90!(212)!548!88!28!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!

Fax:!+90!(212)!548!88!27!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!

Email:[email protected]!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!


NA!

Company!type! NA!Enzyme!sales!absolute!and/or!as!a!percentage!of!company!sales!

Small!

Enzyme!categories! Textiles!Expression!systems! NA!Capacity/scale! Bulk.!!No!in:house!production.!Key!People! NA!Partnerships! BASF,!Akkim,!Novozymes,!Zschimmer&Schwarz!Mohsdorf!Customers! NA!Financial!Health! NA!Catalog!of!Enzymes! ++!(selection!of!about!a!dozen!enzymes)!Toll!Manufacturing! :!!

Alfa!Kimya!is!a!distributer!for!enzymes!from!Novozymes!and!BASF!in!Turkey.!!!

Products:!

Amylase!

Pectinase!

Catalase!

Cellulase!

Protease!(Savinase)!

Laccase!!

! ! !!


AlfaNzyme'BioBTech'

www.alfanzymebiotech.com!!

Plot!No.!72,!Kanbargi!Layout,!Ramteertha!Nagar!

Belgaum!590016!Karnataka!

India!

Tel:!+91:831:3194000/6535248!

Fax:!+91:831:2454688!

Email:[email protected];[email protected]!!


Below!US$1!Million!


Major!source!of!revenues!

Enzyme!categories! Pulp!and!paper,!baking,!animal!feed,!grain!processing,!alcohol!fermentation,!textiles!

Expression!systems! NA!Capacity/scale! Bulk.!!In:house!manufacture!not!specified.!Key!People! Mr.!Manas!Ranjan!Samal!Partnerships! NA!Customers! NA!Financial!Health! NA!Catalog!of!Enzymes! +!Toll!Manufacturing! :!!

AlfaNzyme!Bio:Tech!sells!a!variety!of!agricultural!and!industrial!chemicals!and!bioproducts,!including!enzymes.!

Products:!

Non:specified!enzymes!for!the!enzyme!categories!above,!including:!!

Proteases!

Carbohydrate!hydrolases!

Amylases!

Phytase!

! ! !!


Alliance'Enzyme'Pvt'Ltd!

www.papainenzyme.com!!

2027:2028,!Jash!Market,!Ring!Road!

Surat!:!395002,!Gujarat!

India!

Tel:!+1:91:261:2339493/2363774/3073388!

Fax:!+1:91:261:2334135!


NA!


Nearly!all!revenues!are!enzyme!sales!

Enzyme!categories! Food!and!human!health!applications!Expression!systems! Extraction!from!plant!tissue!Capacity/scale! Bulk.!!In:house!production.!Key!People! Chandresh!Vasani,!Director!Partnerships! NA!Customers! NA!Financial!Health! NA!Catalog!of!Enzymes! +!Toll!Manufacturing! :!!

From!the!website:!“We!are!a!manufacturer,!supplier,!exporter,!importer,!and!trader!of!Pharmaceuticals!Enzyme!such!as!Refined!Papain!Powder!and!Ultra!Refined!Papain!Powder.!We!also!proivde!Food!Enzyme!like!Liquid!Papain!and!Industrial!Enzyme!such!as!Crude!Papain,!USP!Papain!and!IP!Papain.!We!offer!these!products!in!various!grades!and!specifications!as!per!the!needs!of!the!clients.”!

Products:!

Papain!

Bromelain!

!

!

! !

! ! !!


Alltech'

http://www.alltech.com/!!

3032!Catnip!Hill!Pike!Nicholasville!!

Lexington!KY!40356!!

USA!

Tel:!+1:859:885:9613!


1001:5000!employees!


Small!

Enzyme!categories! Animal!feed!enzyme.!!It!calls!its!enzyme!product!Allzyme,!which!is!a!mixture!of!carbohydrate:degrading!enzymes!and!phytase.!

Expression!systems! Naturally!selected!(non:genetically!modified)!strain!of!Aspergillus,niger.!Capacity/scale! Bulk.!!In:house!production!unlikely.!Key!People! NA!Partnerships! NA!Customers! Global,!128!countries.!Financial!Health! +++!Catalog!of!Enzymes! +!Toll!Manufacturing! :!!

Alltech!is!a!manufacturer!and!supplier!of!animal!feed!and!feed!additives.!

Products:!

Phytase!

Xylanase!

Protease!

Cellulase!

Beta:glucanase!

Amylase,!pentosanase,!pectinase!

! !

! ! !!


!

Almac'Sciences'

http://www.almacgroup.com/!!

Almac!House!

20!Seagoe!Industrial!Estate!

Craigavon!BT63!5QD!

UK!

Tel:!+44!28!3833!2200!

Fax:!+44!28!3833!2299!



3,300!

Company!type! Private,!owned!by!Alan!McClay!Foundation!Enzyme!sales!absolute!and/or!as!a!percentage!of!company!sales!

Low!percentage!of!total!sales!

Enzyme!categories! Biocatalysis!Expression!systems! Company!literature!cites!a!‘diverse!range!of!micro:organisms’!and!this!would!

include!E.,coli,Capacity/scale! Grams!to!multi:Kg!scale!in:house!production!(larger!scale!with!partner!DSM!

possible)!Key!People! Stephen!Barr,!PhD,!President!and!Managing!Director;!Denis!Geffroy,!VP,!

Business!development;!Tom!Moody,!!Head!of!Biocatalysis!&!Isotope!Chemistry!

Partnerships! DSM!(DSM!and!Almac!have!access!to!each!other’s!enzyme!collections!in!a!collaboration!that!began!in!2012.)!University!College!of!London!and!Queens!University!are!partners!for!biocatalysis!research.!

Customers! 600+!companies!worldwide,!Pfizer!Financial!Health! +++!(Almac!has!been!growing!organically!and!states!that!it!is!profitable!and!

stable)!Catalog!of!Enzymes! +++!(Offerings!are!growing)!Toll!Manufacturing! +++!!Via!the!partnership!with!DSM,!Almac!manufactures!on!a!relatively!small!

scale!up!to!100s!of!g!or!low!Kgs!of!enzyme!(larger!amounts!of!chemical!intermediates!and!APIs),!and!transfers!manufacturing!to!DSM!or!other!partners!for!larger!orders.!Also!potent!compound!capabilities!using!chemo:biocatalytic!methods.!

!

! ! !!


Based!in!Craigavon,!UK!(near!Belfast,!Northern!Ireland),!Almac!Sciences!is!a!contract!research!organization!for!the!pharmaceutical!industry!offering!a!broad!array!of!services!to!support!pharmaceutical!developments!from!concept!to!product!launch.!Almac!is!a!relatively!new!entrant!in!the!field!of!biocatalysis,!using!enzymes!and!biocatalysts!to!further!expand!the!scope!of!its!pharma!services!to!include!enzymatic!process!development.!As!of!2013,!Almac!has!developed!its!capatilities!in!enzyme!discovery,!evolution,!and!biocatalysis!to!be!one!of!the!leading!companies!in!the!field!worlwide.!!Aimed!primarily!at!applications!for!the!synthesis!of!pharmaceutical!intermediates,!Almac!has!quickly!established!its!reputation!for!high!quality!and!excellent!service.!!Almac!has!branded!its!enzymes!and!technology!as!the!SelectAZymeTM!platform.!

Almac!offers!to!either!conduct!R!&!D!using!biocatalysts!for!route!development!using!in!house!enzymes,!or!to!provide!off!the!shelf!enzymes!directly!to!the!customer.!!The!company!offers!enzyme!kits!with!collections!of!enzymes!as!follows:!

Carbonyl!Reductase!:!CESK:6000!(60!enzymes)! !

Hydrolase!:!HESK:4800!(48!enzymes)! !

Nitrile!Manipulators!:!NESK:2400!(24!enzymes)! !

Nitrilase!:!NiTESK!1500!(15!enzymes)!

Nitrile!Hydratase!:!NiHESK!900!(9!enzymes)!

Aldehyde!Reductase!:!AESK:1600!(16!enzymes)! !

Transaminase!:!TESK:3600!(36!enzymes)!!

Phenylalanine!Dehydrogenase!–!PDESK:500!(5!enzymes)!!

Amine!Oxidase!–!AoESK:800!(8!enzymes)!

Epoxide!Hydrolase!–!EHESK:500!(5!enzymes)! !

P450!Monooxygenase!–!OxESK:1000!(10!enzymes)! !

Ene!Reductase!–!ERESK:1300!(13!enzymes)! !

Hyperactivated!Hydrolase!–!HAHESK:1000!(10!enzyme)!

Human!P450!monooxygenase!–!HosESK:1000!(10!enzymes)!

In!2012,!Almac!began!offering!screening!and!scale!up!services!for!producing!and!identifying!drug!metabolites!using!a!collection!of!cytochrome!P450!enzymes!and!related!catalysts.!!!

!

! ! !!


Alpha'Diagnostic'International,'Inc.'

http://www.4adi.com/!!

6203!Woodlake!Center!!

San!Antonio,!Texas!78244!!

USA!

Tel:!+1:800:786:5777!!

Tel:!+1:210:561:9515!!

Fax:!+1:210:561:9544!



5:20!employees!


Small!

Enzyme!categories! Diagnostics!Expression!systems! NA!Capacity/scale! No!manufacturing!in!house!Key!People! NA!Partnerships! NA!Customers! NA!Financial!Health! NA!Catalog!of!Enzymes! ++!Toll!Manufacturing! :!!

From!the!website:!“Alpha!Diagnostic!International!(ADI)!located!in!San!Antonio,!Texas,!USA,!is!a!major!provider!of!custom!services!such!as!peptides!synthesis!and!polyclonal!antibodies.!ADI!specializes!in!the!development,!manufacture,!and!distribution!of!variety!of!ELISA!reagents!and!kits!for!animal!and!human!research.!ADI!maintains!an!USDA!inspected!and!approved,!animal!facility.!We!have!introduced!a!number!of!specialized!anitbodies!to!a!variety!of!new!genes!including!obese/leptin,!membrane!receptors,!and!neurotransmitter!transporters.”!

Products:!

Acylase!

Alkaline!phosphatase!

! ! !!


Butrylylcholine!esterase!

Beta:glucosidase!

Beta:glucuronidase!

Carbonic!anhydrase!

Catalase!

Cholesterol!oxidase!

Creatinase!

Deoxyribonuclease!

D:amino!acid!oxidase!


Glucose!oxidase!

Peroxidase!

Hyaluronidase!

Lactate!dehydrogenase!

Mutarotase!

Pepsin!

Pyruvate!kinase!

Pyranose!oxidase!

Ribonuclease!

!

!

' '

! ! !!


Amano'Enzyme'

http://www.amano:enzyme.co.jp/!!

1:2:7,!Nishiki,!Naka:ku!

Nagoya!460:8630!!

Japan!!

Tel:!+81:(0)52:211:3032!!

Fax:!+81:(0)52:211:3054!

Email:!www:info@amano:enzyme.ne.jp!!

Year!Founded! 1899!(parent!company),!1948!(Amano!Enzyme),!1981!(Amano!USA)!Size!($!or!employee!count!or!both)!

440!employees!


Almost!all!sales!are!enzymes,!a!small!amount!is!yeast!extract!

Enzyme!categories! Pharmaceutical,!food!processing,!dietary!supplement,!nutraceutical,!biotransformation,!and!diagnostics.!

Expression!systems! A!variety!of!culturable!organisms!Capacity/scale! Muliton!scale,!Amano!owns!about!4!large!manufacturing!plants!in!Japan!and!

China!Key!People! Motoyuki!Amano,!President!Partnerships! NA!Customers! NA!Financial!Health! ++!(estimated)!Catalog!of!Enzymes! +++!(extensive!catalog!of!enzymes!across!many!fields)!Toll!Manufacturing! +!(though!not!advertised!as!a!service,!Amano!has!produced!enzymes!for!

others!including!Altus)!!

Amano!Enzyme!Inc.,!along!with!its!subsidiaries,!develops,!produces,!and!sells!enzymes!for!pharmaceutical,!food!processing,!dietary!supplement,!nutraceutical,!biotransformation,!and!diagnostic!industries!in!Japan.!It!offers!medical!and!food!processing!enzymes!that!are!used!in!digestive!aid!products,!antiinflammatory!enzyme!preparations,!chiral!synthesis,!diagnostic!kits,!dairy!products,!seasonings,!alcoholic!drinks,!and!breads.!The!company!also!offers!non:animal!and!non:GMO!enzymes!in!the!United!States,!Canada,!and!Central!and!South!America;!and!animal!organ!extracts.!Its!enzymes!are!also!used!in!proteins!processing,!starch!processing,!yeast!extract!manufacturing,!oil!and!fat!processing,!and!others.!The!company!was!founded!in!1899!and!is!based!in!Nagoya,!Japan!with!locations!in!Japan,!the!United!States,!the!United!Kingdom,!Switzerland,!Mexico,!China,!and!Malaysia.!

! ! !!


In!biocatalysis!Amano!was!the!developer!of!one!of!the!best!known!lipases!for!resolution!of!chiral!esters,!carboxylic!acids,!and!alcohols:!Lipase!PS!(originally!from!Pseudomonas,cepacia).!

For!food,!diagnostics,!and!biocatlaysis,!Amano!Enzyme!USA,!Inc.!is!an!important!division.!As!a!subsidiary!of!Amano!Enzyme,!Inc.,!Japan,!Amano!Enzyme!USA!supplies!the!North!and!South!American!markets!with!high!quality,!non:animal!and!non:GMO!enzymes!for!the!dietary!supplement,!nutraceutical,!food,!diagnostic!and!pharmaceutical!industries.!

Amano!Enzyme!USA!

2150!Point!Boulevard,!Elgin,!IL!60123!!

[email protected][email protected]!!

847:649:0101!

Products:!

Amano!offers!enzymes!in!the!following!product!categories:!

Acylases!!

Lipases!

Lipoprotein!lipase!

Glycerol!kinase!

L:alpha:glycerophosphate!oxidase!

Cholesterol!dehydrogenase!


Glucose!oxidase!


Malate!dehydrogenase!

Bilirubin!oxidase!

Ascorbate!oxidase!

Peroxidase!

Uricase!

Collagenase!

! ! !!


Hyaluronidase!

Proteases!

Glutaminase!

Laccase!

Lactase!

Hyderase!

Dextranase!

Catalase!


Cellulase!

Diastase!

!

!

' '

! ! !!


American'Biosystems,'Inc.'

http://www.americanbiosystems.com/!!

P.O.!Box!1523!

Roanoke,!VA!24007!

USA!

Tel:!+1:540:344:6469!

Tel:!+1:888:344:6469!!

Fax:!+1:540:301:6451!



11:50!employees!


Important!minority!revenue!source.!

Enzyme!categories! Animal!feed,!textiles!Expression!systems! Trichoderma,reesei,,Trichoderma,sp.,,Trichoderma,viridue,,Pichia,pastoris,,

Aspergillus,oryzae,,Bacillus,subtilis.,Capacity/scale! Bulk,!no!in:house!production.!Key!People! Edward!Goyette,!President!Partnerships! NA!Customers! NA!Financial!Health! NA!Catalog!of!Enzymes! +!(about!10!entries)!Toll!Manufacturing! NA!!

“American!Biosystems,!Inc.!specializes!in!the!production!of!direct:fed!microbials.!!Microbials!can!be!used!in!a!variety!of!different!applications.!Some!are!used!for!animal!feed!and!aquaculture!products.!Others!are!used!in!domestic,!municipal!and!industrial!waste!treatment!products.!Concentrated!enzyme!products!are!useful!in!both!agricultural!and!industrial!applications.”!!!

Products:!

Amylases!

Beta:glucosidase!

! ! !!


Cellulase!

Hemicellulase!

Lipase!

Xylanase!

Phytase!

Beta:mannase!

' '

! ! !!


American'Laboratories,'Inc.''

www.americanlaboratories.com!!

4410!South!102nd!Street!!

Omaha,!Nebraska!68127!!

USA!

Tel:!+1:402:339:2494!!

Fax:!+1:402:339:0801!



30:50!employees!


Major!revenue!source.!

Enzyme!categories! Animal!nutrition,!diagnostics,!food.!Expression!systems! Enzymes!are!isolated!from!natural!materials,!plants!or!animal!glands!Capacity/scale! Three!buildings,!including!a!60,000!sq!ft!manufacturing!facility!Key!People! Jeff!Jackson,!CEO!Partnerships! NA!Customers! Global!Financial!Health! ++!(estimate)!Catalog!of!Enzymes! ++!(about!30!enzyme!products)!Toll!Manufacturing! +!(will!isolate!enzymes!from!animal!or!plant!material!for!customer)!!

From!the!website:!“American!Laboratories,!Inc.!(ALI)!was!started!in!1967!in!Omaha,!NE.!ALI!is!a!specialty!processor!of!Enzymes!(Pancreatin,!Pepsin,!Bromelain,!Papain,!Fungal!and!Custom!Fungal!Enzyme!Blends);!Proteins!(Beef,!Pork!and!Chicken!Liver!Powders);!and!Peptones!(Casein!Hydrolysate,!Microbiotone,!and!Proteose!Micro)!and!sells!to!customers!in!food!processing,!pharmaceutical,!veterinary!health,!nutritional,!and!companion!animal!industries!in!45!countries!!around!the!world.!For!more!information,!visit!www.americanlaboratories.com”!

Products:!

Pancreatin!

Pepsin!

Bromelain!

! ! !!


Papain!

Proteases!


Amylogucosidase!

Beta:glucanase!

Cellulase!

Amylases!

Lactase!

Lipase!

Glucose!oxidase!

Hemicellulase!

Invertase!

Maltase!

Penctinase!

Phytase!

Xylanase!

Diastase!

Trypsin!

' '

! ! !!


Americos'Industries'Inc.'

http://www.kenencoregroup.com/!!

B/610/611,!Ganesh!Plaza!

Nr.!Navrangpura!Post!Office!

Ahmedabad!:!380!009,!Gujarat!

India!

Tel:!+(91)!:!(79)!:!26447781/82,!26447736!

Fax:!+(91)!:!(79)!:!26447736!



50!employees!


Important!minority!revenue!stream.!

Enzyme!categories! Textiles!and!food.!Expression!systems! Fungal!and!bacterial!Capacity/scale! Bulk.!!In:house!production!not!likely.!Key!People! NA!Partnerships! NA!Customers! NA!Financial!Health! NA!Catalog!of!Enzymes! +++!(Americos’!lists!of!enzymes!in!each!textiles!and!food!enzymes!are!very!

extensive)!Toll!Manufacturing! :!!

From!the!website:!“Welcome!to!Americos!Industries!Incorporation,!Manufacturer!and!Supplier!of!Chemical,!Auxiliaries,!Smart!Colorants,!Dyestuffs!and!Enzymes.!The!Company!was!incorporated,!at!Ahmedabad.!We!have!spread!our!wings!to!UK,!USA!and!Indonesia.!Accurate!composition,!International!quality!standards!and!excellent!logistic!support!are!the!factors!that!help!us!to!stay!ahead!of!our!competitors.!We!offer!a!huge!gamut!of!Enzymes,!Colorants,!Dyestuffs,!Flavors!and!Probiotics.!Our!organization!is!instrumental!in!offering!a!wide!gamut!of!Enzymes!and!Colorants.!Abrasives!offered!by!us!are!in!huge!demand!across!the!global!markets.!We!also!provide!Dyestuffs,!Flavors!and!Probiotics!that!are!best!in!the!industry!amongst!others.!Our!Softeners!and!Speciality!Chemicals!are!extremely!reliable.!Along!with!that!we!offer!Finishes,!Auxiliaries!and!Brighteners!that!are!cost!effective.!For!more!information!log!on!at:!http://www.kenencoregroup.com/”!

! ! !!


Products:!

Amylases!

Pectinases!

Cellulases!

Proteases!

Catalase!

Maltase!

Pentosnase!

Glucose!oxidase!

Lipases!

Phospholipase!

Beta:glucosidases!

Esterases!

!

' '

! ! !!


Amit'Biotech'Pvt.'Ltd.'

www.amitbiotech.com!!

Unit!No.!21,!3rd!Floor!

21,!Ballygunge!Circular!Road!

Kolkata!:!700019!

West!Bengal!

India!

Tel:!+91:33:24864118!

Fax:!+91:33:24866454!



51:200!employees!


Very!small!

Enzyme!categories! Animal!nutrition!Expression!systems! NA!Capacity/scale! Bulk.!!In:house!production!not!likely.!Key!People! Amit!Kumar!Rastogi,!Director!Partnerships! NA!Customers! NA!Financial!Health! NA!Catalog!of!Enzymes! +!Toll!Manufacturing! :!!

Amit!is!a!manufacturer!and!distributor!of!a!broad!range!of!products!in!agriculture,!plantation,!animal!and!fish!farming,!and!others.!!!

Products:!

Phytase,!Gluconase,!Pectinase,!Cellulase!

!

' '

! ! !!


AMPLICON'

www.amplicon.cz!!!

Business!dept.!of!Forenzni!DNA!servis,!s.r.o.!

Budinova!2!

180!81!Praha!8!

Czech!Republic!

Tel:!+420!233!123!/!+420!731!503!250!

Fax:!+420!233!123!



NA!


Small!

Enzyme!categories! Life!science!enzymes!Expression!systems! NA!Capacity/scale! No!in:house!production.!!Supplies!laboratory!quantities.!Key!People! NA!Partnerships! Sells!enzymes!from!NZYTech.!Customers! NA!Financial!Health! NA!Catalog!of!Enzymes! +!Toll!Manufacturing! :!!

Amplicon!is!a!supplier!of!life!science!products.!!!

Products:!

Carbohydrate:active!enzymes:!feruloyl!esterase,!glucomannan!acetyl!esterase,!pectin!acetyl!esterase,!xylan!acetyl!esterase,!arabinofuranosidase,!arabinoxylanase,!β:1,4:Glucosidase,!cellobiohydrolase,!chitinase,!cellulases,!β:1,3(4):glucanase,!β:1,3:glucanase,!endo:β:1,4:galactanase,!endo:β:1,4:galactanase,!exo:β:1,3:galactanase,!exo:β:1,4:mannanase,!mannanase,!endo:β:1,4:mannanase,!mannosidase,!xylanase,!xyloglucanase,!α:galactosidase.!

Analytical!and!diagnostic!enzymes:!!

! ! !!


Acetyl:CoA!syntethase!

D:alanine!aminotransferase!!

Alcohol!dehydrogenase!

Aldehyde!reductase!

Arginase!

Aspartate!aminotransferase!

Citrate!synthase!

Glucokinase!


Glucose:6:phosphate!isomerase!


Glutaminase!

Lactadehyde!dehydrogenase!

D:lactate!dehydrogenase!

D:malate!dehydrogenase!

L:malate!dehydrogenase!

NADH!peroxidase!

Sulfite!oxidase.!

!

' '

! ! !!


Ampliqon'A/S'

www.ampliqon.com!!

Stenhuggervej!22!!

5230!Odense!M!!

Denmark!

Tel:!+45!70!20!11!69!!

Fax:!+45!70!20!11!79!!



Small!


Important!minority!revenue!stream!

Enzyme!categories! Life!science,!molecular!biology!Expression!systems! NA!Capacity/scale! Laboratory!scale!Key!People! NA!Partnerships! Distributors!in!many!countries.!Customers! Global!Financial!Health! NA!Catalog!of!Enzymes! +!Toll!Manufacturing! :!!

From!the!website:!“Ampliqon!is!a!small:scale!PCR!enzyme!and!bioreagent!manufacturer.”!

Products:!

DNA!Polymerases!(Recombinant!Taq)!

!

!

!

' '

! ! !!


ANC'Enzyme'Solutions'

http://www.ancenzymes.com/!!

20!Cecil!St,!#14:01!Equity!Plaza!

Singapore,!049705!

Singapore!

Tel/Fax:!+6566185774!



11:50!


Major!revenue!source.!

Enzyme!categories! Textiles,!Pulp!and!Paper,!Starch!and!related!Industries,!Brewing,!Potable!and!Industrial!Alcohol,!Fruit!Juice/Wine!and!Seed/Essential!Oil!Extraction,!Waste!Tratment!and!Animal!Feed!

Expression!systems! Aspergllus,niger,,Bacillus,subtilis,Capacity/scale! Bulk,!a!distributor!only;!no!manufacturing!Key!People! NA!Partnerships! NA!Customers! Asia!Financial!Health! NA!Catalog!of!Enzymes! ++!Toll!Manufacturing! :!!

From!the!web!site:!“ANC!Enzymes!Solutions!Pte.!Ltd.!is!a!privately!owned,!Singapore!based!organization!with!Joint!Ventures!in!India!and!Indonesia.!The!strength!of!ANC!Enzyme!Solutions!Pte.!Ltd.,!in!our!chosen!Industries!of!operation,!arises!from!specific!hands!on!experience!and!first!hand!knowledge!of!the!various!working!parameters!of!the!individual!processes.!!

Our!team!has!extensive!experience!in!Textiles,!Pulp!and!Paper,!Animal!Feed,!Juice!and!Wine,!Brewing,!Potable!and!Industrial!Alcohol,!Wine!and!Edible!Oils.!Also!involved!in!Food,!Seafood/Shrimp!and!Pharma!applications.!We!not!only!have!the!experience!in!applying!various!enzymes!to!these!industries,!we!also!have!been!active!in!many!industries!applying!the!complimentary!Auxiliary!Chemicals!and!Additives!for!the!various!processes.”!

!

! ! !!


Products:!

Amylases!

Xylanase!

Beta:glucosidase!

Mannase!

Pectinases!

Proteases!

Papain!

Laccase!

Phytase!

! !

! ! !!


Andrés'Pintaluba,'S.A.'''''

www.pintaluba.com!!

www.myaenzimas.com!(subsidiary!that!registers!and!markets!the!enzymes)!

Edificio!Grupo!Pintaluba!

Polígono!Industrial!Agro:Reus!

Prudenci!Bertrana,!5!

E:43206!Reus!

Spain!

Tel:!+34!977!317!111! ! ! Fax:!+34!977!323!188!



Medium!to!large!company!



Enzyme!categories! Animal!nutrition!Expression!systems! NA!Capacity/scale! Bulk.!!In:house!production!unlikely.!Key!People! NA!Partnerships! Enzymes!manufactured!by!partner!GNCBioferm!in!Canada.!!Azelis!distributes!

products!in!UK.!Customers! European!market,!Brazil,!Libya,!Argentina.!Financial!Health! NA!Catalog!of!Enzymes! +!Toll!Manufacturing! :!!

From!the!website:!“The!company,!which!initially!focused!on!marketing!additives,!currently!manufactures!and!markets!additives!and!medicated!premixes!for!animal!feed,!nutrition!and!health,!growing!organically!and!developing!in!this!sector!and!in!new!related!fields.”!

Products:!

Pig!and!poultry!enzyme!mixture!formulations!containing:!Beta:glucanases,!Beta:xylanases,!Alpha:amylases,!Phytases!

! ! !!


Anil'Bioplus'

http://www.anilbioplus.com/!!

P.O.!Box!:!10009!

Anil!Road,!Ahmedabad!380025!

Gujarat!!

India!

Tel:!+91(79)22203222!

Tel:!+91(79)22200731!



>1000!employees,!ca.!$100!million!in!annual!revenues!


Major!revenue!stream!

Enzyme!categories! Applications!in!fruit!juices,!brewing,!feed,!food,!pulp!and!paper,!leather,!and!textiles.!!!

Expression!systems! NA!Capacity/scale! Multi:ton!Key!People! Shri!Amol!S.!Sheth,!Director!of!the!Company!Partnerships! NA!Customers! NA!Financial!Health! +++!Catalog!of!Enzymes! ++!!Toll!Manufacturing! :!!

Anil!Bioplus!is!a!public!company!associated!with!the!large!Indian!conglomerate!Anil!Group.!!The!Anil!Group!is!an!association!of!companies!in!everything!from!real!estate,!to!starch!and!milling,!to!enzymes!and!ingredients,!industrial!machinery,!and!more.!!!

From!the!website:!“Anil!Bioplus!Limited!(ABL)!is!a!pioneer!in!manufacturing!of!Industrial!Enzymes,!Microbes!(with!enzymes)!and!Bio:Chemicals!(Calcium!&!Sodium!Gluconate)!through!fermentation!process,!developed!by!in:house!Research!&!Development!Laboratories.!The!company!manufactures!different!grades!of!enzymes!for!end:user!industries!like!Textile,!Paper,!Food!&!Beverages,!Pharmaceuticals,!Feed,!Distilleries!etc.!and!Mineral!Gluconates,!which!are!used!as!source!of!energy!in!

! ! !!


veterinary!applications,!construction!and!chemical!industries.!The!range!of!enzymes!is!marketed!in!both!India!and!international!destinations!through!dedicated!marketing!teams.!

With!growing!globalization!and!increasing!requirements!for!customized!solutions,!the!Application!Development!Cell!at!Anil!Bioplus!works!closely!with!R&D!department!to!provide!the!necessary!support!in!improving!the!customer's!manufacturing!efficiencies!and!the!overall!end!product!quality.!Another!key!function!of!this!cell!is!to!identify!applications!and!areas!for!introducing!new!products!and!new!applications!for!the!existing!products!to!expand!the!markets!and!create!newer!horizons!for!business.!The!cell!also!provides!support!in!trouble!shooting!and!other!technical!services!to!its!customers.!Cell!is!manned!by!specialists!in!end!user!industry.!

The!company,!through!continuous!interaction!with!Research!&!Development!fraternity,!is!steadily!making!efforts!towards!technology!absorption,!adoption!and!innovation.!The!thrust!areas!have!been!ongoing!improvement!of!quality!of!products,!increase!in!productivity!through!costs!and!development!of!new!related!products!for!various!end!uses.”!

Products:!

Amylases!

Cellulase!

Catalase!

Pectinase!

Proteases!

Phytase!

Galactosidases!

Glucoamylases!

!

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Anthem'Cellutions'

http://www.anthemcell.com/!!

F1&F2,!Canara!Bank!Road!

Bommasandra!Industrial!area!Phase!I!

Hosur!Road,!Bangalore!:560099!

India!

Tel:!+91:80:40444000/66724000!

Fax:!+91:80:40444020/66724020!



Parent!company!has!over!400!employees.!

Company!type! Private,!a!division!of!Anthem!BioSciences!Enzyme!sales!absolute!and/or!as!a!percentage!of!company!sales!


Enzyme!categories! Enzymes!for!baking,!fruit!juice!processing,!starch!processing,!textiles,!detergents,!leather,!pulp!and!paper,!and!oil!field!applications.!!!

Expression!systems! NA!Capacity/scale! Large!Key!People! Ajay!Bharadwaj,!CEO!Partnerships! One!supplier!of!Anthem’s!offerings!is!Verenium!through!WeissBiotech!Customers! NA!Financial!Health! NA!Catalog!of!Enzymes! ++!Toll!Manufacturing! NA!!

From!IRCA!Lt!credit!rating:!“Anthem!Cellutions!(India)!Limited!is!primarily!engaged!in!the!manufacturing!and!processing!of!nutraceutical!products,!enzymes!and!actives!for!various!applications!in!healthcare,!food!&!beverages,!textiles,!detergents!and!animal!health!industries!etc.!!The!Company!derives!majority!of!its!revenues!from!the!nutraceutical!and!animal!feeds!segment.!!Presently,!the!company’s!manufacturing!facility!is!situated!in!Bommasandra!Industrial!Area!in!Bangalore!where!the!company!manufactures!actives,!enzymes!and!probiotics.!Along!with!the!associated!concern!ABPL,!ACIL!employs!over!400!employees!including!over!200!scientists!who!work!!towards!developing!differentiated!molecular!formulations.!Using!these!capabilities,!the!Company!focuses!on!producing!niche!variants!of!already!existing!products.”!

! ! !!


Products:!

Proteases!

Papain!

Pectinases!

Amyloglucosidases!

Amylases!

Glucoamylases!

Cellulases!

Xylanases!

Lipases!

Catalase!

Mannase!

!

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Apollo'Chemical'Company'

http://www.apollochemical.com/!!

2001!Willow!Springs!Lane!

Burlington,!NC!27215!

USA!

Tel:!+1:336:226:1161!

Fax:!+1:336:570:6246!


NA!


Small!

Enzyme!categories! NA!Expression!systems! NA!Capacity/scale! Bulk.!!No!in:house!production.!Key!People! NA!Partnerships! NA!Customers! NA!Financial!Health! NA!Catalog!of!Enzymes! +!Toll!Manufacturing! NA!!

From!the!website:!“Our!products!supply!the!Graphic!Arts,!Carpet,!Coatings,!Industrial!Chemicals,!Apparel,!Hosiery,!Denim,!Automotive!Fabric,!and!Home!Furnishings!markets.”!

Products:!

Listed!are!“enzymes”!and!“scouring!enzymes”(e.g.!pectinase)!and!catalase!

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Apollo'Scientific'

http://www.apolloscientific.co.uk/!!

Apollo!Scientific!Ltd,!Whitefield!Rd!

Bredbury,!Stockport,!Cheshire,!SK6!2QR!

UK!

Tel:!+44!(0)161!406!0505(5!lines)!

Fax:!+44!(0)161!406!0506(4!lines)!



11:50!


Small!

Enzyme!categories! A!diverse!selection!of!188!enzymes!is!offered.!!Applications!include!cofactor!regeneration,!life!science/DNA!manipulation,!diagnostics,!and!biocatalysis.!

Expression!systems! NA!Capacity/scale! Lab!scale,!distributor!only!Key!People! NA!Partnerships! Many!suppliers.!Customers! Global!Financial!Health! NA!Catalog!of!Enzymes! ++!Toll!Manufacturing! :!!

Apollo!is!a!supplier!of!laboratory!chemicals,!and!it!supplies!laboratory!amounts!of!enzymes!as!a!distributor.!

Products:!

Extensive!list,!188!different!enzymes!for!research!

!

!

!

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Applied'Biotechnology'Institute'

http://www.appliedbiotech.org/!!

Cal!Poly!Technology!Park!

Building!83:1D!

San!Luis!Obispo,!CA!93407:3405!

USA!

Tel:!+1:805:756:6458!!!!!!!!!!!!!!!!!!!!!!!!!!!


Year!Founded! Mid:!to!late:2000’s!Size!($!or!employee!count!or!both)!

1:10!employees!


none!

Enzyme!categories! NA!Expression!systems! Recombinant!production!in!plants!including!corn!Capacity/scale! NA!Key!People! John!Howard,!Founder!and!President!Partnerships! Works!with!Infinite!Enzymes!to!produce!a!cellulose:degrading!enzyme!in!

corn!seed.!Customers! NA!Financial!Health! NA!Catalog!of!Enzymes! :!Toll!Manufacturing! +!(small!scale)!!

From!the!website:!“ABI!is!a!research!company!that!develops!new!product!concepts!and!performs!early!stage!product!development.!ABI!partners!with!other!companies!for!latter!stages!of!product!development,!production!and!sales.!ABI!uses!its!platform!technology!is!to!express!recombinant!proteins!that!provide!health!and!environmental!benefits!to!society.!!ABI!takes!advantage!of!the!unique!characteristics!of!plants!to!overproduce!recombinant!proteins.!In!particular,!it!selects!proteins!that!are!suited!for!this!particular!technology!to!achieve!an!advantage!over!traditional!methods!of!over:expressing!proteins.!!ABI’s!system!of!choice!is!maize!grain!to!produce!recombinant!proteins.!!In!addition!to!the!general!features!of!maize!grain!that!make!it!attractive,!ABI!has!issued!and!pending!patents!that!favor!high!expression.”!

! !

! ! !!


Archaezyme'Ltd'

http://www.archaezyme.com/!!

16!Hacharash!Street,!Room!213!

Ness!Ziona!70!400!

Israel!

Tel:!+972:8:940:6210!

Fax:!+972:8:940:9819!



1:10!employees!


NA!

Enzyme!categories! Enzymes!are!in!development!for!the!synthesis!of!oligosaccharides!including!polyphosphate!glucokinase!(PPGK)!and!polyphosphate!kinase!(PPK).!!Thermostable!enzymes!from!thermophilic!organisms.!

Expression!systems! NA!Capacity/scale! Small!Key!People! Mathew!Weisman,!CEO!Partnerships! NA!Customers! Markets!worldwide!Financial!Health! NA!Catalog!of!Enzymes! +!(2!products!in!development)!Toll!Manufacturing! +!(small!operation)!!

Archaezyme!Ltd.,!is!a!contract!enzyme!developer.!!The!company!offers!biochemistry!services!in!purifying!and!analyzing!proteins,!and!offers!consulting!services!in!enzyme!applications.!!Archaezyme!is!named!as!such!because!it!has!investigated!stable!enzymes!from!thermophiles.!!The!company!appears!to!be!a!small!1:2!person!firm.!

Products:!

Polyphosphate!glucokinase!(PPGK)!

Polyphosphate!kinase!(PPK)!

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ArcticZymes'

http://arcticzymes.com/!!

Sykehusveien!23!

9019!Tromsø!

Norway!

Tel:!+47!77!64!89!00!



About!25!employees!

Company!type! 96%!owned!by!public!company!Biotec!Pharmacon!ASA!(Oslo!Stock!Exchange!under!the!BIOTEC!ticker!symbol)!


Enzyme!sales!are!about!75%!of!revenue,!remainder!is!government!grants!

Enzyme!categories! Molecular!biology!and!diagnostics.!!Heat:labile!enzymes.!!!Expression!systems! Shrimp!alkaline!phosphatase!originally!isolated!from!shrimp!now!produced!

recombinantly!in!Pichia,pastoris.!!E.,coli!(ung:)!for!Cod!UNG.!!SAN!and!dsDNase!produced!recombinantly!in!Pichia,pastoris.!

Capacity/scale! Laboratory!to!kg!scale!Key!People! Svein!W.!F.!Lien,!CEO!(also!CEO!of!parent!company!Biotech!Pharmacon)!Partnerships! GE!Healthcare!Life!Sciences;!Percorso!Life!Sciences,!LLC!located!in!Plymouth!

Meeting,!PA!for!establishment!of!USA!branch!of!company;!New!England!Biolabs!and!Affymetrix!Inc!for!distribution!of!products;!Research!Council!of!Norway!for!funding!of!multiple!projects!

Customers! Global!through!distributors!Financial!Health! +!(small!operating!loss,!parent!company!recently!raised!capital)!Catalog!of!Enzymes! +!(small!catalog,!valuable!well:selling!enzymes)!Toll!Manufacturing! :!!

From!the!company!website:!!

“ArcticZymes!AS!has!a!long!history!dating!back!to!the!late!1980’s!with!its!foundation!firmly!planted!in!the!fishing!industry!of!Northern!Norway.!In!the!mid:1990’s!Biotec!Pharmacon!acquired!the!technology!for!production!of!Shrimp!Alkaline!Phosphatase!and!built!a!department!for!production!of!molecular!grade!enzymes.!In!June!2009!Biotec!Pharmacon!created!ArcticZymes,!a!96%!owned!subsidiary.!

ArcticZymes!has!a!rich!history!in!the!ability!to!leverage!its!access!to!the!marine!Arctic;!identify!novel!cold:adapted!enzymes!for!us!in!molecular!research!and!diagnostics,!manufacture,!and!commercialize!our!enzyme!portfolio.”!

! ! !!


Products:!

Shrimp!alkaline!phosphatase!

Cod!Uracil:DNA!Glycosylase!(Cod!UNG)!

dsDNase!

Salt!Active!Nuclease!(SAN)!

Kits!of!the!preceding!enzymes!

!

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Ares'Bioscience'GmbH'(Genecraft)'

http://www.genecraft.de/!!

Graeffstr.!5!

50823!Köln!

Germany!

Phone:! +49!(0)221!17072583!

Fax:!+49!(0)221!17072585!



NA!


NA!

Enzyme!categories! Life!science!enzymes:!restriction!enzymes,!polymerases.!Expression!systems! NA!Capacity/scale! Lab!scale!Key!People! Dimitrij!Plachov,!CEO!Partnerships! NA!Customers! NA!Financial!Health! NA!Catalog!of!Enzymes! +++!(extensive!catalog)!Toll!Manufacturing! :!!

The!most!recent!catalog!on!the!website!of!Genecraft!dates!to!2008,!so!there!is!some!doubt!to!whether!or!not!this!company!remains!in!existence.!!

From!the!company!website:!“GENECRAFT!is!an!German!biotechnology!company!that!markets!molecular!biology!products.!Since!its!founding!in!1996,!the!company!continues!to!expand!its!marketing!worldwide.!Our!growth!has!been!built!on!long!term!experience!of!Russian!scientists!in!the!development!and!production!of!unique!molecular!biology!products.!As!a!result,!we!are!able!to!supply!the!life!sciences!market!with!inexpensive,!top!quality!products,!generally!at!half!the!cost!of!competitive!products!on!the!European!market.!

Its!core!competencies!encompass!several!areas:!PCR!and!PCR:based!technologies;!cDNA!technologies;!gene!analysis;!and!nucleic!acid!chemistry.!

! ! !!


Recently,!the!company!has!released!a!number!of!innovative!products.!The!list!of!restriction!enzymes!offered!by!GENECRAFT!includes!some!unique!isoschizomeres,!not!provided!by!other!suppliers.!Several!tools!and!kits!for!molecular!biology!are!also!offered.”!

Products:!

Restriction!enzymes!

DNA!Polymerases!

!

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Arun'and'Co'

http://www.arunandco.com/!!

Polaris,!6th!floor!

Off!Marol!Maroshi!Road,!Behind!Sangeet!Plaza!

Marol,!Andheri!(east)!

Mumbai!:!400!059!

India!

Tel:!+91:22:6772!3000!!

Fax:!+91:22:6725!3399!



5:10!million!USD!


Important!minority!revenue!source.!

Enzyme!categories! Diagnostics,!molecular!biology!Expression!systems! Limited!!Capacity/scale! Likely!no!in:house!production!Key!People! NA!Partnerships! Suppliers:!Novozymes!A/S,!Denmark;!Dishman!Netherlands!B.V.!(formerly!

Solvay);!BBI,!U.K.;!Organo!Technie!S.A.,!France,!Worthington!Biochemical!Corporation,!USA;!Institut!Rosell!/!Lallemand,!Canada;!Boval!Company,!USA;!Kem:en:tec,!Denmark!

Customers! “rich!list!of!customers,!which!includes!almost!all!leading!companies!in!pharmaceutical,!textile,!diagnostics,!oil,!starch,!baking!and!other!industries”!in!India!

Financial!Health! ++!(estimation!based!on!company!size,!long!history!and!distribution!model)!Catalog!of!Enzymes! +++!Toll!Manufacturing! :!!

Arun!and!Co.!began!as!a!distributor!for!enzymes!from!international!manufacturers,!and!continues!to!operate!primarily!as!a!distributor.!The!company!is!a!primary!manufacturer!for!only!a!few,!if!any,!enzyme!products,!buying!n!the!enzymes!it!sells!from!Novozymes,!BBI,!and!others.!!Product!offerings!have!expanded!beyond!enzymes!to!include!a!range!of!biology:based!products.!

! ! !!


From!the!company!website:!“Arun!&!Co.!currently!develops,!manufactures!and!markets!a!wide!range!of!products!including!enzymes!of!diagnostics,!research!&!industrial!grades,!biochemicals,!probiotics,!enzyme!/!probiotic!formulations!and!reagents!for!research!&!diagnostics.!!Arun!&!Co.!has!set!up!a!full:fledged!laboratory!for!its!R&D!activities!in!the!commercial!capital!of!India,!Mumbai!alongside!its!corporate!office.!From!the!very!inception,!Arun!&!Co.!has!believed!in!building!a!strong!base,!not!only!for!new!products,!but!also!for!application!technology.”!

Products:!

Elastase!

Enterokinase!

Leucine!aminopeptidase!

Pepsin!

Prolidase!

Trypsin!

Acetylcholinesterase!

Acylase!


Arginase!

Butyrylcholine!esterase!

Carbonic!anhydrase!

Catalase!

Hyaluronidase!

Lactoperoxidase!

Lipoxidase!

Superoxide!dismutase!

Triose:phosphate!isomerase!

Xanthine!oxidase!

Alpha:amylase!

! ! !!


Alpha:glucosidase!

Deoxyribonucleases!

Lysozyme!

Ribonuclease!

Collagenase!


Alcohol!oxidase!

Aldehyde!dehydrogenase!

Aminolevulinate!dehydratase!

Ascorbate!oxidase!

Cholesterol!esterase!


Glucose!oxidase!

Beta:glucosidase!


Glyceraldehyde:3:phosphate!dehydrogenase!

Hexokinase!


Lipoamide!dehydrogenase!



Mutarotase!

Peroxidase!

Phosphoenolpyruvate!carboxylase!

Pyruvate!kinase!

! ! !!


Urease!

Xanthine!oxidase!

Phosphatase!

Creatine!kinase!

Glutamic:oxaloacetic!transaminase!

Glutamic:pyruvic!transaminase!

Gama:glutamyl!transferase!

!

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ASA'Spezialenzyme'GmbH'

http://www.asa:enzyme.de/!!

Am!Exer!19c!

38302!Wolfenbüttel!

Germany!

Tel:!+49!(0)!5331!8825:30!

Fax:!+49!(0)!5331!8825:32!

Email:!grotrian@asa:enzyme.de!!


ca.!10:20!employees!



Enzyme!categories! Food!and!feed,!pulp!and!paper,!textiles,!biocatalysis,!biopolymer!degradation,!biofuels.!!!

Expression!systems! Bacillus,,Aspergillis,,Trichoderma,,Kluvyermyces,,Pichia,,Rhizopas,,Candida,,E.,coli,,Rhodococcus,!others.!

Capacity/scale! Bulk,!in:house!production!likely.!Key!People! Arno!Cordes,!Founder!Partnerships! Has!collaborated!with!academia,!has!participated!in!government!grants.!Customers! NA!Financial!Health! ++!(estimated!to!be!profitable,!long!history)!Catalog!of!Enzymes! +++!(wide!range!of!typical!and!hard:to:find!enzymes)!Toll!Manufacturing! ++!(offers!R+D!services,!can!produce!batch!amounts)!!

ASA!earns!a!substantial!portion!of!its!revenue!from!bacteria!mixed!cultures!for!pond!and!lake!water!quality!management.!!The!company!manufactures!a!diverse!group!of!enzymes!in!an!equally!diverse!set!of!expression!hosts.!!!

From!the!company!website:!“The!business!activities!of!ASA!Spezialenzyme!GmbH!cover!the!

development,!production!and!marketing!of!enzymes,!microbial!mixed!cultures!and!other!

biotechnological!products.!Since!the!foundation!in!the!year!1991!we!have!continuously!developed!our!

competence!in!the!area!of!special!enzymes.!Our!product!range!covers!the!fields!of!application!in:!food!

and!feed!processing,!organic!synthesis,!analytics,!biosensors,!textile!industry,!paper!industry.!In!the!area!

of!mixed!cultures!we!offer!products!for!industrial!and!private!use.!The!main!applications!for!

! ! !!


microorganisms!are!the!lake!and!pond!restoration!as!well!as!the!improvement!of!water!quality!in!

aquariums,!garden!ponds!and!commercial!aquacultures.”!

Products:!

Proteases!

Pectinase!

Lactase!

Lipase!

Cellulase!

Amylases!

Alcohol!oxidases!

Chitinase!

Chlorperoxidase!

Esterases!

Laccases!

Peroxidase!

Phytase!

Tannases!

Penicillin!acylase!

L:Phenylalanine!dehydrogenase!

S:Oxynitrilase!

R:Oxynitrilase!

Manganese!peroxidase!

L:Leucine!dehydrogenase!

!

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Asahi'Kasei'

http://www.asahi:kasei.com/!!

1:105!Kanda!Jinbocho,!Chiyoda:ku!

Tokyo!101:8101!

!Japan!

Year!Founded! 1931!(parent!company)!Size!($!or!employee!count!or!both)!

28,000!employees!(parent!company)!


Small!

Enzyme!categories! Diagnostics!Expression!systems! A!wide!range!of!native!and!recombinant!hosts!including!Arthrobacter,,

Pseudomonas,,Pyrococcus,,Candida,,Acremonium,,Bacillus,,Rhodococcus,,Streptococcus,,Chromobacterium,,Vibrio,,Geobacillus,!etc.!!

Capacity/scale! Bulk.!!In:house!production!likely.!Key!People! NA!Partnerships! NA!Customers! Global!Financial!Health! +++!(large!public!company)!Catalog!of!Enzymes! +++!(about!50!enzymes)!Toll!Manufacturing! :!!

Through!its!subsidiary!Asahi!Kasei!Pharma,!the!parent!company!Asahi!Kasei!sells!enzymes!for!diagnostic!applications.!!Asahi!Kasei!offers!a!large!product!range!in!the!diagnostic!enzyme!market.!

Products:!!

Lipases!

Kinases!

Aminotransferases!

Amylases!

Alkaline!phosphatases!

Dehydrogenases!

Uricase!

! ! !!


Tyramine!oxidase!

Sphingomyelinase!

Pyruvate!oxidase!

Isomerases!

Phospholipases!

Phosphorylases!

Hexokinses!

Daphorase!

Cholesterol!oxidases!

Bilirubin!oxidase!

Alcohol!oxidase!

!

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AUM'Enzyme'

www.aumenzymes.com!!

30,!Bhakti!Nagar,!Nr.!Jalaram!Mandir!

BORSAD:388!540!

Dist.!Anand.!(Gujarat)!!

India!

Tel:!+91:2696:221891:!9898383455!



NA!


NA!

Enzyme!categories! Textiles,!leather,!animal!feed,!baking,!detergents,!alcohol!production,!starch!processing,!brewing,!waste!water!treatment.!!

Expression!systems! Bacillus,,Trichoderma,,Aspergillus,Capacity/scale! Bulk.!!In:house!production!likely.!Key!People! NA!Partnerships! NA!Customers! NA!Financial!Health! NA!Catalog!of!Enzymes! ++!Toll!Manufacturing! :!!

From!the!company!web!site:!“Aumenzymes'is!a!metabolic!engineering!firm!specializing!in!generally!regards!safe!microbial!origin!industrial!technical!grade!enzymes!produced!by!solid!state!fermentation!and!submerge!fermentation.!The!firm's!core!skills!are!total!enzymes!solution!under!one!roof.!AUM'Enzyme!has!been!serving!the!needs!of!technical!grade!enzymes!users!in!various!field!viz.!Like!Enzymes!for!Textile!Industry,!Enzymes!for!Leather!Industry,!Enzymes!for!Animal!Feed!Industry,!Enzymes!for!Baking!Industry,!Enzymes!for!Detergent,!Enzymes!for!Alcohol!Industry,!Enzymes!for!Starch!Processing,!Enzymes!for!Brewing!Industry,!Enzymes!for!Protein!Modification,!Enzymes!for!Effluent!Treatment,!etcAUM!Enzymes!may!be!associated!with!Aumgene,!a!company!nearby!in!India.“!AUM!Enzymes!claims!to!be!the!number!1!enzyme!producer!in!India.!!

!

! ! !!


Products:!Extensive!list,!including!

Phytase!

Amylases!

Proteases!

Beta:glucanase!

Xylanase!

Cellulase!

Hemicellulase!

Catalase!

Lipases!

Peptidases!!

Glucoamylase!

Naraginase!

!

!

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Aumgene'Enzyme'

http://www.aumgene.com/!!

Aumgene!Biosciences!Pvt.!Ltd.!

8201/5,!Road!No.!8!

GIDC!Sachin,!Surat!

India!

Tel:!+91:261:!3255755,!2399499!

Tel:!+91:9825062475,!9377755550!

Fax:!+91:261:2399409!



5:10!employees!



Enzyme!categories! Textile,!leather,!pulp!and!paper,!detergent,!fruit!juice,!baking,!animal!feed,!brewing,!biofuels,!pharma,!biocatalysis.!

Expression!systems! NA!Capacity/scale! Fermenters!up!to!3000!L.!!In:house!production.!Key!People! Anand!Daga,!Founder!&!Director!Partnerships! NA!Customers! NA!Financial!Health! NA!Catalog!of!Enzymes! +!(wide!range!of!offerings)!Toll!Manufacturing! +++!(fermenters!up!to!3000!L)!!

From!the!company!web!site:!“Aumgene!Biosciences!Pvt.!Ltd.!is!a!research!driven!Biotech!company!based!in!Surat,!India.!The!company!focuses!on!development,!production!and!commercialization!of!enzymes!and!microbial!products!through!classical!as!well!as!recombinant!approach.!The!company!has!extensive!experience!in!development!&!manufacturing!of!enzymes.!The!company!has!commercialized!several!enzymes!for!food,!pharma!,Industrial,!and!biocatalysis!applications.!The!company's!present!R&D!product!pipeline!has!three!high!value!enzymes!in!late!stage!development.!The!company!also!offers!contract!research!and!fermentation!process!development!&!manufacturing!services!to!clients!in!and!outside!India.!

! ! !!


Aumgene!is!one!of!the!few!biotech!companies!in!India!with!R&D,!Pilot!and!Production!scale!fermentation!infrastructure!under!the!same!roof.”!

Aumgene!also!offers!contract!research!services!in!enzyme!development!and!applications.!

Products:!

Amylases!

Amyloglucosidases!

Cellulases!

Catalase!

Lipases!(including!lipases!for!biocatalysis)!

Glucanases!

Hemicellulases!

Phytase!

Proteases!

Mannanase!

Xylanase!

Laccase!

Pectinase!

!

!

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BASF'(Also'see'Verenium,'acquired'in'late'2013)'

www.basf.com!!

Carl:Bosch:Strasse!38!

67056!Ludwigshafen!

Germany!

Telephone:!+49!(0)621!60:0!

Fax:!+49!(0)621!60:42525!


110,000!employees!


Very!small!as!percentage!of!total!chemical!sales,!but!aggressively!growing.!

Enzyme!categories! Detergents,!animal!feed,!proteases,!likely!cellulases!pending,!textile!and!oil!field!enzymes.!

Expression!systems! Many,!including!Dyadic’s!C1!platform!Capacity/scale! Nearly!unlimited!Key!People! Kurt!Bock,!Chairman!of!the!Board!of!Executive!Directors;!Kai!Baldenius,!Head!

of!Biocatalysis!Partnerships! BASF!scientists!are!involved!in!numerous!alliances!with!leading!universities,!

research!institutes,!startups,!industry!partners,!and!customers,!more!than!1300!of!which!are!based!in!Europe.!

Customers! Global!Financial!Health! +++!!Catalog!of!Enzymes! ++!(growing,!and!produced!on!large!scale)!Acquisition!of!Verenium!will!

expand!the!list!of!industrial!enzymes!Toll!Manufacturing! :!!

BASF!is!the!world’s!largest!chemical!company,!and!the!company!produces!and!sells!chemicals,!plastics,!performance!products,!agricultural!products,!enzymes,!and!fine!chemicals.!!!The!company!has!recently!been!pushing!aggressively!into!the!use,!manufacture,!and!sale!of!enzymes.!!!

In!May!2013,!BASF!announced!a!partnership!with!Dyadic!to!use!the!Dyadic!C1!expression!and!production!platform!to!manufacture!industrial!enzymes,!and!this!partnership!also!gives!BASF!access!to!cellulases.!!BASF!is!collaborating!with!Direvo!to!develop!a!protease!for!pig!and!poultry!feed!applications.!!!BASF!also!purchased!Henkel’s!detergent!enzymes!business!in!2013.!!!

! ! !!


Continuing!its!aggressive!expansion!into!enzyme!markets,!in!September!of!2013!BASF!announced!that!it!is!acquiring!San!Diego,!California:based!Verenium,!which!will!give!it!immediate!access!to!new!enzyme!products!and!market!channels!including!amylases,!phytases,!cellulases,!and!xylanase.!!The!acquisition!of!Verenium!in!late!2013!will!also!add!a!US!location,!research!in!enzyme!evolution,!and!manufacturing!capabilities.!See!the!entry!for!Verenium!for!additional!information.!

Enzyme!Products:!

Cellulase!

Protease!

Amylases!

Phytase!

Lipase!for!biocatalysis!applications!

Ketoreductases!for!biocatalysis!applications!

!

See!entry!for!Verenium,!page!400:401,!for!additional!enzymes!now!produced!and!offered!by!BASF.!

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BBI'Enzymes'

http://www.bbienzymes.com!!

73!Ty!Glas!Avenue!

Cardiff,!CF14!5DX!!

UK!

Tel!(UK):!08444!176393!

Tel!(USA):!+1:800:423:8199!

Tel!(International):!+44!(0)!2920!747!232!



450!employees!(parent!company)!

Company!type! Private.!!BBI!enzymes!is!part!of!BBI!solutions,!which!is!in!turn!a!company!within!the!BBI!group.!


Small!

Enzyme!categories! Diagnostics!Expression!systems! Multiple!sources,!mainly!isolation!from!natural!organisms,!but!some!

recombinant!production!as!well.!Capacity/scale! Up!to!700!Kg!batches.!!In:house!production.!Key!People! NA!Partnerships! NA!Customers! Global!Financial!Health! +++!(estimated!to!be!profitable)!Catalog!of!Enzymes! +++!(50+!enzymes)!Toll!Manufacturing! :!!

From!the!company!website:!“BBI!Enzymes!is!a!manufacturer!of!enzymes!for!diagnostic!and!pharmaceutical!applications.!Manufacturing!sites!Blaenavon,!Wales!(formerly!Biozyme)!and!Cape!Town,!S!Africa!(formerly!Seravac).!Key!products!include!Glucose!Oxidase,!Horse!Radish!Peroxidase,!Alkaline!Phosphatase,!Trypsin/Chymotrypsin!and!Hyaluronidase.!

BBI!Solutions!manufacture!a!diverse!range!of!enzymes!derived!from!microbial,!animal!and!plant!tissues,!including!our!market!leading!glucose!oxidase!and!horseradish!peroxidase.!These!are!manufactured!in!our!purpose!built!laboratories!in!the!UK!and!South!Africa,!enabling!us!to!provide!you!with!economical!

! ! !!


batch!sizes!of!up!to!700!kg.!BBI!Solutions!enzymes!are!ideal!for!a!variety!of!applications!including!clinical!chemistry,!biosensor!manufacture!and!ELISA!assay.!

BBI!Solutions!products!are!not!intended!for!use!in!pharmaceutical!applications!and!does!not!offer!active!pharmaceutical!ingredients!for!sale!in!the!USA.”!

Products:!

Acylase!

Alanine!transaminase!

Alkaline!phosphatase!

Alpha:amylase!

Ascorbate!oxidase!

Aspartate!aminotransferase!

Beta:glucuronidase!

Butyrylcholine!esterase!

Catalase!

Cathepsin!G!



Chymotrypsin!

Chymotrypsinogen!

Creatine!kinase!

Creatinine!amidohydrolase!

Creatinine!deiminase!

Cytochrome!C!


Deoxyribonuclease!

Elastase!

! ! !!



Gamma:glutamyl!transaminase!


Glucose!oxidase!


Glycerol!kinase!

Glycerophosphate!oxidase!

Hexokinase!

Hyaluronidase!


Lipoprotein!lipase!

Lipoxidase!

Lysozyme!


Mucopolysaccharidase!

Mutarotase!

Pepsinogen!

Peroxidase!

Phosphoenolpyruvate!carboxylase!

Ribonuclease!

Sarcosine!oxidase!


Trypsin!

Uricase!

Urease!

! ! !!


Xanthine!oxidase!

!

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BehnMeyer'

www.behnmeyer.com!!

Ballindamm!1!

20095!Hamburg!

Germany!

Tel:!+49!40!30299!0!

Fax:!+49!40!30299!319!


950!employees!


Small!

Enzyme!categories! Animal!nutrition!Expression!systems! Trichoderma,,Bacillus,Capacity/scale! Bulk.!!In:house!production!not!likely.!Key!People! Christian!Traxel,!Hoh!Sooi!Kim,!Christa!Lorenz:Meyer,!Supervisors!Partnerships! NA!Customers! Global!Financial!Health! ++!Catalog!of!Enzymes! +!Toll!Manufacturing! :!!

Behn!Meyer!is!a!conglomerate!including!business!interests!in!paper!and!board,!agriculture,!ingredients,!performance!chemicals,!and!polymers.!!!

Products:!

Phytase!

Carbohydrate!hydrolases!

!

!

!

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BELDEM'(A'Puratos'Group'Company)'

http://www.beldem.com/!!

Industrialaan!25:28!

Zone!Maalbeek!

1702!GROOT!BIJGAARDEN!

Belgium!

Tel:!+!32!2!481!44!44!

Fax:!+!32!2!466!25!81!!



Large!company!

Company!type! Private,!part!of!the!Puratos!Group!Enzyme!sales!absolute!and/or!as!a!percentage!of!company!sales!

Enzymes!are!a!part!of!overall!product!mix!of!emulsifiers,!yeasts,!sourdoughs,!yeast!extracts,!and!enzymes.!

Enzyme!categories! Animal!feed!&!pet!food,!baking!industry,!beverages!industry,!milling!industry.!!!Expression!systems! Aspergillus,,Bacillus.!Capacity/scale! Bulk.!!In:house!production.!!!Key!People! NA!Partnerships! NA!Customers! Global!Financial!Health! +++!Catalog!of!Enzymes! ++!Toll!Manufacturing! :!!

From!the!company!website:!“Beldem!is!integrated!in!the!new!PURATOS!Group!organization!as!a!part!of!the!Strategic!Business!Unit!Bakery!and!has!been!divided!into!3!Business!Units!:!B.U.!Enzymes,!B.U.!Emulsifiers!and!B.U.!Bioflavours!&!Yeast.”!

Products:!

Xylanases!

Alpha:amylases!

Pectinases!

Beta:glucanase' !

! ! !!


Berg'+'Schmidt'GmbH'&'Co.'KG'

www.berg:schmidt.de!!

An!der!Alster!81!!

20099!Hamburg!!

Germany!

Tel:!+49!(0)!40/284!039:0!!

Fax:!+49!(0)!40/284!039:33!!

Email:!info@berg:schmidt.de!!!

Year!Founded! Founded!more!than!50!years!ago.!Size!($!or!employee!count!or!both)!


Company!type! Owned!by!parent!company!the!Stern:Wywiol!Gruppe!Enzyme!sales!absolute!and/or!as!a!percentage!of!company!sales!

Significant!revenue!source,!likely!a!minority!portion.!

Enzyme!categories! Animal!nutrition.!Expression!systems! NA!Capacity/scale! Bulk.!!No!in:house!production.!Key!People! Andreas!Reith,!Torsten!Wywiol,!Volkmar!Wywiol:!Managing!Directors!Partnerships! Enzymes!are!made!by!other!companies!within!the!Stern:Wywiol!Group.!Customers! Global!Financial!Health! NA!Catalog!of!Enzymes! +!Toll!Manufacturing! :!!

Berg!+!Schmidt!is!a!supplier!of!both!specialty!fat!powders!and!enzyme!formulations!for!animal!nutrition.!!The!fats!are!refined!products!of!palm!oil.!!!

Products:!

The!company!sells!enzyme!formulations!under!the!trade!name!Bergazyme!that!include:!

Pentosanases!(probably!xylanases)!

Glucanases!

!

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! ! !!


Begerow'

www.begerow.com!!

Branch!Langenlonsheim!

An!den!Nahewiesen!24!

55450!Langenlonsheim!

Germany!

Tel:!+49!6704!204:0!

Fax:!+49!6704!204:121!

Email:!info:[email protected]!!


270!

Company!type! Owned!by!public!company!Eaton!(Ticker:!ETN)!Enzyme!sales!absolute!and/or!as!a!percentage!of!company!sales!

Small!

Enzyme!categories! Fruit!juice,!beverage,!winemaking.!Expression!systems! Aspergillus,,extraction!from!animal!tissue,Capacity/scale! Bulk.!!In:house!production!unlikely.!Key!People! Hans:Jakob!Vogt,!Anton!Mandt,!Managing!Directors!Partnerships! NA!Customers! Global!Financial!Health! +++!Catalog!of!Enzymes! ++!Toll!Manufacturing! :!!

From!the!company!website:!“We!are!the!specialists!for!liquid!filtration!processes!in!the!beverage!and!food!industry!as!well!as!in!the!chemical,!pharmaceutical!and!industrial!sector.”!

Products:!

Pectinases,!Beta:glucosidases,!Beta:glucanases,!Lysozyme,!Amylases,!Amyloglucosidase!

!

!

'

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BERLIN'TEXTILE'CHEMICALS'(ZHONGSHAN)'CO.,'LTD'

www.berlinchem.com!!

South!Area,!Jinxi!Village!

Zhongshan!City,!Guangdong!Province,!528455!

China!

Tel:!+86:760:88899180!!

Fax:!+86:760:88899280!!



NA!


Small!

Enzyme!categories! Textiles!Expression!systems! NA!Capacity/scale! Bulk.!!No!in:house!production.!Key!People! NA!Partnerships! NA!Customers! NA!Financial!Health! NA!Catalog!of!Enzymes! +!Toll!Manufacturing! :!!

From!the!company!website:!“We!have!been!supplying!a!wide!range!of!products!to!the!textile!dyeing,!printing,!washing,!finishing!and!non!woven!industry!since!1982.!Besides!formulating!our!own!products,!we!are!also!representing!a!number!of!world!renowned!chemical!manufacturers!as!agents!or!distributors!in!Asia!and!mainland!China.!While!our!headquarters!is!in!Hong!Kong!,!we!set!up!Berlin!Textile!Chemicals!(Zhongshan)!Company!Limited!in!1999,!introducing!advanced!technology!into!the!production!of!dyeing!and!printing!auxiliaries,!and!special!printing!paste!series!as!well.!In!order!to!meet!customers'!demand,!we!have!established!our!own!Research!&!Development,!laboratory,!customer!service,!formulation!facilities!and!delivery!team.”!

Products:!

Cellulases! !

! ! !!


BiCT'srl'

http://www.bict.it/!!

P.Iva!e!Cf!01274450194!!

Parco!Tecnologico!Padano,!Via!Einstein!SNC!loc.!Cascina!Codazza!!

26900!Lodi!(LO)!

Italy!

Tel:!+39!0371!4662452!

Tel:!+39!0371!4662523!



11:50!


LIkely!small!

Enzyme!categories! Immobilized!enzymes;!beta:Galactosidase,!Acylase,!Proteases,!Lipases!Expression!systems! E.,coli,,Saccharomyces,cerevisiae,,Kluyveromyces,lactis,and,Pichia,pastoris,Capacity/scale! Small!scale!manufacture,!mg!scale.!Key!People! Roberto!Verga,!CEO!and!Business!Development!Manager!Partnerships! Works!with!Resindion!for!enzyme!immobilization.!!BiCT!takes!part!in!several!

European!grants,!for!example!the!INNOVAZYME!2012!and!Kyrobio!grants.!Customers! NA!Financial!Health! NA!Catalog!of!Enzymes! +!(small!catalog)!Toll!Manufacturing! +!(at!small!scale)!!

From!the!company!website:!“BiCT!is!a!company!focused!on!the!research!and!production!of!bio:molecules!such!as!enzymes!and!secondary!metabolites,!obtained!either!from!natural!source!(plant,!animal!and!micro!organism)!and!through!recombinant!DNA!techniques.!!BiCT!expertise!ranges!from!molecular!biology!until!heterologous!expression,!purification!and!immobilization!of!biocatalysts!for!selective!biotransformation.!!The!main!company!goal!is!to!provide!very!cost:effective!and!industrial!scale!biocatalyst!and!bioprocesses,!tailoring!them!on!a!client!specific!basis,!thanks!to!our!tight!cooperation!with!Resindion,!a!subsidiary!of!Mitsubishi!Chemical!Corporation!producing!chromatography!resins!and!enzyme!carriers.!!The!R&D!in!molecular!biology!and!protein!expression!is!actually!focused!on!GRAS!(Generally!Regarded!As!Safe)!micro:organisms,!such!as!conventional!and!unconventional!yeasts.!!

! ! !!


The!BiCT!technology!on!biocatalysis!is!currently!applied!in!several!processes!in!different!fields!(from!food!to!pharma,!from!nutraceutics!to!cosmetics).”!

Products:!

Immobilized!enzymes!

Beta:Galactosidase!

Acylase!

Proteases!

Lipases!

!

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BIOBCAT'

www.bio:cat.com!!

9117!Three!Notch!Road!

Troy,!VA!22974!!

USA!

Tel:!+1:877:912:4622!!

Tel:!+1:434:589:4777!


50!employees!


Enzymes,!enzyme!testing!and!blending!services,!and!microbe!formulations!make!up!all!revenues.!

Enzyme!categories! Food,!beverage,!baking,!animal!nutrition,!detergents,!textiles,!cleaning.!!!Expression!systems! Bacillus,,Aspergillus,,Trichoderma,,Chaetomium,,Rhizopus,,Carica,,Candida.!Capacity/scale! Multi:ton!blending.!!No!in:house!production.!Key!People! Edward!Schuler,!CEO!and!Founder!Partnerships! Distributor!for!Amano!Enzyme!and!Shin!Nihon!Chemical.!Customers! NA!Financial!Health! +++!(growing!and!profitable)!Catalog!of!Enzymes! ++!Toll!Manufacturing! :!(Bio:Cat!does!custom!blending!and!is!the!largest!enzyme!custom!blender!in!

the!USA)!!

Bio:Cat!is!a!manufacturer,!blender,!and!supplier!of!enzyme!formulations.!!!The!company!also!custom!blends!and!tests!enzyme!products!as!a!service,!and!additionally!supplies!microbial!cultures.!!It!is!unclear!how!much!fermentative!enzyme!production!expertise!the!company!has,!if!any.!!The!company!purchases!many!of!its!enzymes!from!leading!enzyme!bulk!suppliers!and!does!the!blending!and!formulating!in!house.!!!

Products:!!

Proteases!


Amyloglucosidase!

Beta:glucanase!

! ! !!


Bromelain!

Catalase!

Cellulases!

Dextranase!

Amylases!

Lactase!

Hemicellulase!

Invertase!

Lipase!

Papain!

Pectinase!

Peptidase!

Phytase!

Xylanase!

Glucose!oxidase!

!

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BiocatCollection'

http://www.biocatcollection.net/!!

Harburger!Schloßstraße!6:12!

D:21079!Hamburg!

Germany!

Tel:!+49:40:42878:4368!

Fax:!+49:40:42878:2729!!


Year!Founded! ca.!2007!Size!($!or!employee!count!or!both)!

1:10!employees!

Company!type! BiocatCollection!is!set!up!by!TuTech!Innovation!GmbH,!a!private!company.!Enzyme!sales!absolute!and/or!as!a!percentage!of!company!sales!

100%!

Enzyme!categories! Biocatalysis!Expression!systems! !Capacity/scale! Lab!scale!Key!People! Helmut!Thamer,!CEO;!Garabed!Antranikian,!President!and!CSO!Partnerships! The!BiocatCollection!was!initiated!by!the!Deutsche!Bundesstiftung!Umwelt!

(German!Environmental!Foundation,!www.dbu.de).!Customers! Global!Financial!Health! NA!Catalog!of!Enzymes! ++!Toll!Manufacturing! :!!

The!BiocatCollection!is!a!spin:off!of!the!InnovationCentre!for!Biocatalysis!at!the!Hamburg!University!of!Technology,!Germany.!!Its!mission!is!to!bring!enzymes!discovered!in!academia!to!become!widely!available!for!reasonable!prices.!!Academic!and!other!institutions!can!submit!their!enzymes!to!BiocatCollection!for!purchase!by!others.!!BiocatCollection!in!this!regard!is!an!enzyme!broker.!!There!are!about!300!enzymes!in!the!company’s!collection,!and!they!are!available!in!small!quantities!at!relatively!low!prices.!!!

Products:!

Lipases!

Esterases!

! ! !!


Cellulases!

Amylases!

Pullulanases!

Sugar!modifying!enzymes!

Proteases!

Nitrile!hydratases!

Nitrilases!

Amidases!

Alcohol!dehydrogenases!

Aldolases!!

Kinases!

Carbonic!anhydrases!

Unique!enzymes,!e.g.!an!amylomaltase!and!a!branching!enzyme.!!!

Many!of!the!above!enzymes!are!‘extremozymes,’!active!in!a!broad!temperature!and!pH.!!!

!

! !

! ! !!


!

Biocatalysts'Limited'

http://www.biocatalysts.com!!!

Cefn!Coed!

Parc!Nantgarw!

CF15!7QQ!

Wales!

UK!

Tel:!+44!(0)!1443!843!712!

Fax:!+44!(0)!1443!846!500!



51:100!


Enzyme!sales,!enzyme:derived!product!sales,!and!contract!R+D!all!generate!revenue.!

Enzyme!categories! Food,!dairy,!baking,!and!beverage.!!!Expression!systems! Probably!many!Capacity/scale! Multi:kilogram,!750!L!fermentor.!!In:house!production.!Key!People! Stuart!West,!Managing!Director;!Andrew!Ellis,!New!Product!Development!

Manager!Partnerships! Many!partnerships!globally.!!Sales!office!in!the!USA.!Customers! Many!globally.!Financial!Health! ++!(reports!20%!growth!annually)!Catalog!of!Enzymes! +++!Toll!Manufacturing! +++!!

Biocatalysts!Ltd!is!both!a!provider!of!a!range!of!off!the!shelf!enzymes!and!a!CRO/CMO.!!The!contract!service!business!has!grown!steadily!and!the!company!has!had!many!partners!and!customers!over!the!years.!!The!catalog!of!enzymes!is!substantial.!Recombinant!capabilities!include!host!strains!E.,coli!and!Bacillus.!Company!has!worked!on!a!variety!of!other!enzymes!on!a!contract!basis,!including!many!applicable!to!pharmaceutical!biocatalysis.!

!

! ! !!


Products:!

Muramylodextrinase!

Phenylalanine!dehydrogenase!

Glucanase!

Amylases!

Catalase!

Pepsin!

Mannitol!dehydrogenase!

Pectinase!

Tannase!

Trypsin!

Proteases!

Lipases!

Esterases!

!

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Biochem'Zusatzstoffe'HandelsB'und'Produktionsgesellschaft'mbH'

www.biochem.net!!

Küstermeyerstraße!16!!

49393!Lohne!

Germany!

Tel:!+49!4442!92890!

Fax:!+49!4442!928928!



NA!


Minority!revenue!stream!

Enzyme!categories! Animal!feed!Expression!systems! NA!Capacity/scale! Bulk.!!No!in:house!production.!Key!People! NA!Partnerships! Sister!companies!in!France,!Russia,!Ukraine,!Egypt,!Poland,!Serbia,!Romania,!

Iran!and!Turkey!serve!further!regions!within!and!outside!Europe.!!Suppliers!include!DuPont!and!AB!Enzymes.!

Customers! Europe,!Middle!East.!Financial!Health! NA!Catalog!of!Enzymes! +!Toll!Manufacturing! :!!

Biochem!is!a!distributor!of!animal!feed!additives.!

Products:!

Phytase!

Amylases!

Xylanases!

Proteases!

! !

! ! !!


Biomin'

http://www.biomin.net/!!

Industriestrasse!21!

3130!Herzogenburg!

Austria!

Tel.:!+43!2782!803!0!

Fax:!+43!2782!803!11308!



Large!


Relatively!small!but!important!portion!

Enzyme!categories! Animal!feed!enzyme!phytase.!!FUMzyme,!a!unique!enzyme!that!degrades!toxic!fungal!derived!fumonisins!in!animal!feed.!

Expression!systems! NA!Capacity/scale! Bulk.!!In:house!production.!Key!People! NA!Partnerships! NA!Customers! Global.!Financial!Health! +++!Catalog!of!Enzymes! +!Toll!Manufacturing! :!!

Biomin!is!an!animal!nutrition!company.!

Products:!

Phytase!

FUMzyme,!an!esterase!that!hydrolyzes!fumonisins!

!

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BIOBPORT'Europe's.r.o.'

www.bio:port.cz!!!

Svinaře!98!

267!28!Svinaře!!

Czech!Republic!

Tel:!+420!272!659!617!!!!!!!

Fax:!+420!296!150!761!

Email:!obchod@bio:port.cz!!!


Small!


Small!

Enzyme!categories! Life!science!enzymes!Expression!systems! NA!Capacity/scale! No!in:house!production.!!Laboratory:scale!quantitites.!Key!People! NA!Partnerships! Many.!!Sells!NZYTech!enzymes!Customers! NA!Financial!Health! NA!Catalog!of!Enzymes! +!Toll!Manufacturing! :!!

BioPort!is!a!supplier!of!life!science!products.!!!

Products!from!NZYTech:!


Analytical!enzymes:!acetyl:CoA!syntethase,!D:alanine!aminotransferase!alcohol!dehydrogenase,!aldehyde!reductase,!arginase,!aspartate!aminotransferase,!citrate!synthase,!glucokinase,!glucose:6:phosphate!dehydrogenase,!glucose:6:phosphate!isomerase,!glutamate!dehydrogenase,!glutaminase,!

! ! !!


lactadehyde!dehydrogenase,!D:lactate!dehydrogenase,!D:malate!dehydrogenase,!L:malate!dehydrogenase,!NADH!peroxidase,!sulfite!oxidase.!

!

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BioPox'

http://www.biopox.com!!

Salita!Arenella,!9!80129!Naples!

Italy!



1:10!employees!


NA!

Enzyme!categories! Pulp!and!paper,!textiles,!biofuels,!waste!water!treatment,!drug!manufacture,!biosensors.!

Expression!systems! NA!Capacity/scale! Small!Key!People! Alessandra!Piscitelli!Partnerships! NA!Customers! NA!Financial!Health! Startup,!likely!unprofitable!currently.!Catalog!of!Enzymes! +!(about!5!listed!laccases)!Toll!Manufacturing! +!(service:based!small!scale!operation)!!

BioPox!was!founded!to!commercialize!laccase!enzymes.!!They!intend!to!engineer!laccases!using!directed!evolution!for!a!broad!range!of!enzymes!including!pulp!and!paper,!textiles,!effluent!treatment,!biofuels,!biosensors,!drug!manufacture,!etc.!!BioPox!also!offers!protein!expression!services!to!generate!revenue.!!!

Key!Enzyme!Products:!

Laccases!

!

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'Biorbyt'Ltd.'

www.biorbyt.com!!

5!Orwell!Furlong!

Cowley!Road!

Cambridge!

Cambridgeshire!

CB4!0WY!

UK!

Tel:!+44!(0)1223!859!353!!!!!!!!!!!!!!!!!!!!!!!!!!!!!

!Fax:!+44(0)1223!280!240!



11:50!employees!


Very!small!

Enzyme!categories! Life!science!and!molecular!biology!Expression!systems! None!Capacity/scale! Laboratory!scale.!!No!in:house!production.!Key!People! NA!Partnerships! Global!distributors!Customers! Global!Financial!Health! NA!Catalog!of!Enzymes! ++!Toll!Manufacturing! :!!

Biorbyt!is!a!supplier!of!an!extensive!catalog!of!laboratory!reagents.!

Products:!

More!than!200!enzyme!offerings!including!restriction!enzymes!and!other!enzymes!for!DNA!and!RNA!manipulation,!diagnostic!enzymes,!and!life!science!enzymes.!

! !

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BioResearch'Products'

http://www.bio:researchprod.com/!!

323!West!Cherry!Street!

North!Liberty,!IA!52317!

USA!

Tel:!+1:800:326:3511!

Tel:!+1:319:626:2423!

Fax:!+1:319:626:2240!

Email:!pbaehr@bio:researchprod.com;!bio@bio:researchprod.com!!!


About!25!employees,!about!$4!million!annual!revenues!

Company!type! Subsidiary!of!IBEX!since!2013!Enzyme!sales!absolute!and/or!as!a!percentage!of!company!sales!

Revenues!comprised!of!enzyme!sales!and!custom!manufacturing!

Enzyme!categories! Diagnostics,!biocatalysis,!industrial!applications!Expression!systems! Caldariomyces,fumago!wild:type!and!plant!sources.!Capacity/scale! In:house!capacity!for!!40!L!and!300!L!fermentations,!scale!up!to!1000!L!at!the!!

Biocatalysis!and!Bioprocessing!Center!of!the!University!of!Iowa!Key!People! Paul!Baehr,!President!and!CEO!Partnerships! NA!Customers! NA!Financial!Health! +!Catalog!of!Enzymes! ++!Toll!Manufacturing! ++!!

BioResearch!Products!was!acquired!by!IBEX!Technologies,!Inc.!(www.IBEX.ca)!in!on!December!31,!2012,!and!now!operates!as!a!wholly:owned!subsidiary.!As!of!October!2013,!the!North!Liberty,!Iowa!site!is!still!in!operation.!

From!the!website:!“Founded!in!1975,!Bio:Research!Products,!Inc.!(BRP)!specializes!in!manufacture!of!enzymes!for!biomedical!manufacturing!and!research.!Recognized!as!the!worlds!leading!producer!of!wheat!germ!phosphoenolpyruvate!carboxylase!(PEPC),!BRP!provides!the!following!services:!Protein!purification,!characterization!and!analysis,!diagnostic!reagent!components,!custom!enzyme!production,!contract!manufacturing!of!raw!material!enzymes!for!diagnostics,!pharmaceutical!and!industrial!applications.”!

! ! !!


!

Products:!

Chloroperoxidase!

Immobilized!chloroperoxidase!

Soybean!peroxidase!

Immobilized!soybean!peroxidase!

Wheat:germ!phosphoenolpyruvate!carboxylase!

Maize!phosphoenolpyruvate!carboxylase!

Glutathione!reductase!

Diamine!oxidase!

!

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Bioron'GmbH'

http://www.bioron.net/!!

Rheinhorststr.!18!

67071!Ludwigshafen!

Germany!

Tel:!+49!621!5720!915!

Fax:!+49!621!5720!916!



20:50!employees!


Substantial!portion!

Enzyme!categories! Molecular!biology!Expression!systems! E.,coli,Capacity/scale! Lab!scale!Key!People! Sergei!Kovalenko,!Managing!Director!(CEO)!Partnerships! NA!Customers! Multiple!countries,!Germany!and!the!Middle!East!Financial!Health! NA!Catalog!of!Enzymes! +!Toll!Manufacturing! :!!

Bioron!supplies!molecular!biology!tools!and!enzymes!for!research!use.!!!

Products:!

Proteinase!K!

T4!Ligase,!T4!RNA!Ligase,!T4!Polynucleotide!kinase!!

DNA!polymerase!

Exonuclease!III!

Inorganic!pyrophosphatase!

Uracil:DNA!glycosylase!(UDG)!

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Bioseutica'Group'

www.bioseutica.com!!

!

Bioseutica!B.V.!!!

Landbouwweg!83!

3899!BD!Zeewolde!

The!Netherlands!!!

Tel:!+31.36.522.6300!!!

Fax:!+31.36.522.6833!

!

Neova!Technologies!Inc.!!!

31212!Peardonville!Road!

Abbotsford!BC!V2T!6K8!!!

Canada!!

Tel:!+1.604.504.0695!!!

Fax:!+1.604.859:2679!!

Email:[email protected]!!!

!

FORDRAS!SA!!!

Corso!Elvezia!4!

6900!Lugano!

Switzerland!!!

Tel:!+41.091.972.5005!!!

Fax:!+41.091.972.9411!


! ! !!


!


201:500!employees!


Major!portion!of!revenues!

Enzyme!categories! Dairy,!animal!and!human!health,!winemaking!and!brewing!Expression!systems! All!enzymes!are!extracted!from!animal!tissue!Capacity/scale! Bulk!Key!People! Henk!Altena,!Financial!Controller!Partnerships! Company!is!comprised!of!three!businesses:!Bioseutica!(Netherlands),!Fordras!

SA!(Switzerland),!and!Neova!Technologies!(Canada)!Customers! Global!Financial!Health! NA!Catalog!of!Enzymes! +!Toll!Manufacturing! :!!

From!the!website:!“Bioseutica!is!an!integrated,!specialty!pharmaceutical!group!dedicated!to!the!development!of!the!highest!quality!products,!using!natural,!renewable!sources!for!the!healthcare,!food!and!feed!industries.!!Bioseutica!focuses!on!the!global!supply!of!the!highest!quality!bioactive!proteins,!including!egg!derived!proteins,!such!as!egg!lysozyme,!avidin!or!ovotransferrin!and!pancreatic!enzymes.!Bioseutica’s!manufacturing!processes!are!built!on!high:end,!cutting:edge!proprietary!technology!and!allow!us!to!produce!ingredients!of!highest!purities!in!our!manufacturing!facilities!in!Canada!and!Europe.”!

Products:!

Lysozyme!

Trypsin!

Phospholipase!

!

!

!

!

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Biosphere'

http://www.biospheresrl.com/!!

Via!Cellaimo!3532!Bertinoro!(Forlì:Cesena)!

Italia!47032!!

Italy!

Tel:!+39.0543444597!!

Fax:!+39.0543444600!!



1:10!employees!



Enzyme!categories! Biocatalysis!Expression!systems! Burkholderia,cepacia,,Aspergillus,,Pseudomonas,fluorescens,,Candida,rugosa,,

Candida,antarctica,,Kluyveromyces,lactis,,Bacillus,megaterium,,Escherichia,coli,,Bacillus,licheniformis,,Saccharomyces,cerevisiae,,Pichia,pastoris,,Hansenula,polymorpha,

Capacity/scale! Fermenters!up!to!1500!L!Key!People! Marco!Pistocchi,!Chief!Operating!Officer;!Arianna!Andreotti,!Business!

Development!Manager!Partnerships! BiCT,!Actygea,!BioPox!Customers! NA!Financial!Health! NA!Catalog!of!Enzymes! ++!(medium!sized!selection,!all!immobilized)!Toll!Manufacturing! ++!!!

From!the!company!website:!“With!more!than!ten!years!of!hands:on!experience!in!pharmaceutical,!cosmetic!and!food!biotech!industry,!our!scientists!and!technical!staff!developed!skills!ranging!from!microbial!fermentation!process!development,!to!process!scale!up!and!recovery!of!products.!Biosphere!provides!a!qualified!contract!manufacturing!service!for!the!production!of!microbial!biomass,!enzymes!and!metabolites.!Our!laboratories,!pilot!plants!and!production!facilities!are!designed!to!work!with!microorganisms!up!to!bio!safety!level!2!and!GMOs.!Biosphere!collaborates!with!companies,!universities,!research!institutes!and!scientific!networks!in!several!research!projects,!with!private!or!public!funding.!The!contract!R&D!service!is!mainly!addressed!to:!!the!study!of!new!enzymes!for!the!Pharmaceutical!sector;!the!improvement!and!innovation!of!traditional!products!and!valorisation!of!by:products!in!the!

! ! !!


Food!and!Feed!sectors;!the!development!of!active!substances!from!microbial!source!for!the!cosmetic!industry.!Biosphere!was!founded!in!1999!as!the!biotechnology!division!and!R&D!center!of!SFIR!Group,!a!leading!Italian!player!in!the!sugar!industry.!In!2002!Biosphere!became!an!independent!company!after!the!development!of!new!projects!and!the!start!of!the!production!activities.!In!2012!Orogel!SpA,!Softer!SpA!and!Ayrion!Sustech!SpA!became!new!shareholders!of!the!company,!together!with!SFIR!SpA.”!

Products:!

Immobilized!enzymes!

Lipases:!7!enzymes!

Beta:galactosidases!(2!enzymes)!

Amidases!(2!enzymes)!

Subtilisin!

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Biovet'

http://www.biovet.com/!!

3а!Nikolay!Haytov!Str.!

1113!Sofia!

Bulgaria!

Tel:!+!359!2!862!53!ext.!30,!31,!36!

Tel:!+!359!2!868!2095!

Fax:!+!359!2!862!5334!


Over!1000!employees!

Company!type! Public:!53b!(SOFIX)!Enzyme!sales!absolute!and/or!as!a!percentage!of!company!sales!

Important!minority!contributor!to!revenues!

Enzyme!categories! Animal!feed,!human!health.!!!Expression!systems! Trichoderma,longibrachiatum,!others!not!disclosed!Capacity/scale! Multi:ton.!In:house!production!likely.!Key!People! Kiril!Domuschiev,!President!Partnerships! NA!Customers! Global.!!50%!of!sales!in!European!Union!Financial!Health! +++!Catalog!of!Enzymes! ++!Toll!Manufacturing! :!!

From!the!company!website:!“BIOVET!is!a!leading!European!manufacturer!and!marketer!of!medicated!and!nutritional!feed!additives,!enzymes,!bulk!active!substances!and!pharmaceuticals!for!farm!animal!productivity!and!animal!health.!The!company!offers!intermediates,!active!ingredients!and!medicines!for!the!human!pharmaceuticals!industry.!We!provide!enzymes,!enzyme!complexes!and!other!ingredients!for!the!baking,!brewing,!juice!production,!alcohol!production,!wine:making,!oil!extraction,!pharmaceuticals,!paper,!detergents,!leather!and!textiles!industries.”!!

Products:!

Endo:1,4:beta!glucanase!

Endo:1,3(4):ß:glucanase!

Pentosanase!

! ! !!


Hemicellulase!

α:Amylase!

Protease!

Xylanase!

Phytase!

!

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Biozym'Scientific'GmbH'

www.biozym.com!!!

Steinbrinksweg!27!

31840!Hessisch!Oldendorf!

Germany!

Tel:!+49!(0)!51!52!/!90!20!

Fax:!+49!(0)!51!52!/!20!70!



NA!


Small!

Enzyme!categories! Molecular!biology!enzymes.!Expression!systems! NA!Capacity/scale! Lab!scale!Key!People! Hartmut!Groth,!President!Partnerships! Finnzymes,!Enzymatics!Customers! NA!Financial!Health! NA!Catalog!of!Enzymes! +!Toll!Manufacturing! :!!

Biozym!Scientific!sells!life!science!tools!and!reagents.!!The!company!is!a!reseller/retailer!and!does!not!carry!out!manufacturing!of!enzymes!in!house.!!!

Products:!

Ligases,!DNA!and!RNA!polymerases,!Reverse!transcriptase,!Nucleases,!Kinase!

Glycosylase!

Phosphatase!

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Bio'Zyme'

www.biozyme.ro!!!

Strada!Zorilor,!nr.!40!ap.15!

400335!Cluj:Napoca!

Romania!

Tel:!+40!264!523!281!

Fax:!+40!264!523!281!



NA!


Small!

Enzyme!categories! Life!science!enzymes.!Expression!systems! NA!Capacity/scale! No!in:house!production.!!Supplies!laboratory:quantities.!Key!People! NA!Partnerships! Many.!!Sells!NZYTech!enzymes.!Customers! NA!Financial!Health! NA!Catalog!of!Enzymes! +!Toll!Manufacturing! :!!

BioZyme!is!a!supplier!of!a!broad!range!of!life!science!products.!!!



Analytical!enzymes:!acetyl:CoA!syntethase,!D:alanine!aminotransferase!alcohol!dehydrogenase,!aldehyde!reductase,!arginase,!aspartate!aminotransferase,!citrate!synthase,!glucokinase,!glucose:6:phosphate!dehydrogenase,!glucose:6:phosphate!isomerase,!glutamate!dehydrogenase,!glutaminase,!

! ! !!


lactadehyde!dehydrogenase,!D:lactate!dehydrogenase,!D:malate!dehydrogenase,!L:malate!dehydrogenase,!NADH!peroxidase,!sulfite!oxidase.!

!

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BRAIN'AG!(Biotechnology!Research!And!Information!Network!AG)!

http://www.brain:biotech.de!!

Darmstädter!Straße!34:36!

64673!Zwingenberg!

Germany!!

Tel:!+49!(0)!62!51!/!9331:0!

Fax:!+49!(0)!62!51!/!9331:11!

Email:!public@brain:biotech.de!!!


105!employees!


Revenue!is!from!contract!R+D,!some!government!grants.!

Enzyme!categories! NA!Expression!systems! Actinomyces,,E.,coli,,others!Capacity/scale! Probably!pilot!scale,!up!to!a!few!hundred!L!fermentation.!Key!People! Holger!Zinke,!CEO!and!founder;!Jürgen!Eck,!CTO.!!!Partnerships! Partnership!with!Enzymicals!for!biocatalysis!in!the!pharmaceutical!industry.!!

In!its!history,!BRAIN!has!more!than!80!collaborations/partnerships!with!leading!companies!like!BASF,!Ciba,!Clariant,!DSM,!Evonik!Degussa,!Henkel,!Nutrinova,!Sandoz,!Schering,!Südzucker!und!Symrise.!!BRAIN!purchased!the!German!cosmetic!firm!LA!Schmitt,!giving!it!integration!of!the!development,!production,!and!sale!of!cosmeticals.!Ownbs!an!equity!stake!in!German!enzyme!developer!!Enzymicals!AG!(vide!infra).!

Customers! Contract!research!carried!out!for!mostly!European!companies:!BASF,!Ciba,!Clariant,!DSM,!Evonik!Degussa,!Henkel,!Nutrinova,!Sandoz,!Schering,!Südzucker!und!Symrise.!!

Financial!Health! ++!(well!funded)!Catalog!of!Enzymes! :!Toll!Manufacturing! +!(mostly!R+D)!!

BRAIN!has!traditionally!focused!on!contract!research!services!rather!than!product!sales.!!The!company!has!been!a!contract!research!organization!for!most!of!its!existence,!and!has!worked!with!many!well:known!companies.!!In!November!2012,!the!company!raised!€60!million!from!the!Putsch!family!and!MIG!Fonds.!!It!has!outlined!a!‘buy!and!build’!strategy!to!make!use!of!its!new!capital!infusion,!indicating!that!more!acquisitions!will!be!initiated!by!BRAIN.!!BRAIN!has!extensive!libraries!of!microorganisms!and!

! ! !!


recombinantly!expressed!genes!from!culturable!and!unculturable!organisms.!!It!calls!its!platform!EvoSolution®,!and!this!platform!encompasses!its!BioArchive!of!tens!of!thousands!of!microbial!strains!and!its!Biodiversity!library.!!The!Biodiversity!library!consists!of!genes!from!culturable!and!unculturable!organisms!expressed!as!large!insert!libraries,!LIL®.!!The!company!has!strong!robotics!and!screening!capabilities.!!BRAIN!applies!its!technology!to!enzymes!and!biocatalysts,!to!designer!microorganisms,!and!to!producing!bioactive!compounds.!!!

!

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Brenntag'

www.brenntag.com!!

Stinnes:Platz!1!

D:45472!Mülheim/Ruhr!!

Germany!

Tel:!+49!(0)!208/7828:0!


13,000!employees!

Company!type! Public.!!Ticker:!BNR!Enzyme!sales!absolute!and/or!as!a!percentage!of!company!sales!

Very!small!

Enzyme!categories! Animal!nutrition!Expression!systems! None!Capacity/scale! Bulk.!!No!in:house!production.!Key!People! Steven!Holland,!CEO!Partnerships! Distributes!enzymes!for!AB!Enzymes.!Customers! Global!Financial!Health! +++!Catalog!of!Enzymes! +!Toll!Manufacturing! :!!

From!the!press:!“Brenntag,!the!global!market!leader!in!chemical!distribution,!covers!with!its!extensive!product!and!service!portfolio!all!major!markets.”!

Products:!

A!chemical!distributor!whose!distributed!products!include!enzymes.!Product!line!not!specified!on!web!site,!but!distributes!for!AB!Enzymes.!!See!AB!Enzymes!entry!for!details!on!their!product!lines.!In!September!2013!Brenntag!acquired!the!chemical!distribution!business!of!ZYtex!Group!in!India.!The!biotechnology!and!food!ingredients!distribution!business!will!become!part!of!Brenntag!India,!headquartered!in!Mumbai.!The!acquired!business!has!its!focus!on!enzymes!and!yeast!for!a!broad!application!range!in!the!food!and!beverage!industries!in!India.!!

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B.S.C.'nv'

www.bscbio.be!!

Zwaarveld!41!!

9220!Hamme!

Belgium!

Tel:!+32!52!47.05.36!!

Fax:!+32!52!47.26.64!



Small!



Enzyme!categories! Food,!feed,!beverage,!human!health.!Expression!systems! Extraction!from!papaya!(plant!tissue)!Capacity/scale! Bulk!Key!People! NA!Partnerships! NA!Customers! NA!Financial!Health! NA!Catalog!of!Enzymes! +!Toll!Manufacturing! :!!

From!the!company!website:!“B.S.C.!is!deeply!committed!in!the!development,!formulation!and!marketing!of!niche!market!biochemicals!based!on!natural!active!components!for!the!food–feed:beverage!and!pharma!industry.”!

Products:!

Papain!

!

!

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!

C.Schliessmann'

http://www.c:schliessmann.de/!!

Kellerei:Chemie!GmbH!&!Co.KG!

Auwiesenstrasse!5!

DE!:!74523!Schwäbisch!Hall!

Germany!

Tel:!+49:(0)791/97191:0!

Fax:!+49:(0)791/97191:25!

Email:!service@c:schliessmann.de!!


Small!

Company!type! Private,!family!owned!by!the!Heller!family!Enzyme!sales!absolute!and/or!as!a!percentage!of!company!sales!

Relatively!small!

Enzyme!categories! Winemaking!and!distillation!alcohol!production!enzymes.!Expression!systems! None!Capacity/scale! None!Key!People! Rudolf!Heller,!President!Partnerships! Distributes!enzymes!from!WeissBiotech,!which!in!turn!are!manufactured!by!

Verenium.!Customers! NA!Financial!Health! NA!Catalog!of!Enzymes! ++!Toll!Manufacturing! :!!

C.Schliessmann!is!a!provider!of!winemaking!and!distillation!alcohol!production!goods!including!yeasts,!enzymes,!fermentation!additives,!analytical!services,!and!equipment.!!!

Products:!

Pectinases,!Amylases,!Proteases,!Xylanases,!Hemicellulases,!Beta:glucanase!

!

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C5.6'Technologies'

http://c56technologies.com/!!

2905!Parmenter!Street!

Middleton,!WI!53562!

USA!

Tel:!+1:608:836:3587!

Fax:!+1:608:836:3626!



4!employees!


Small!

Enzyme!categories! 34!cellulase!degrading!enzymes!sold!through!partner!Lucigen!Expression!systems! NA!Capacity/scale! Small!Key!People! David!Mead,!CEO!and!Co:Founder!Partnerships! Spun!out!of!Lucigen!Customers! NA!Financial!Health! NA!Catalog!of!Enzymes! ++!(unique!cellulase:degrading!enzymes)!Toll!Manufacturing! NA!!

From!the!company!website:!“C5•6!Technologies!Inc.!creates!bio:based!solutions!to!efficiently!convert!biomass!into!five!and!six!carbon!sugars.!The!company!is!developing!the!next!generation!of!enzyme!solutions!that!are!up!to!50!fold!more!potent!than!competing!products.!As!part!of!its!enzyme!screening!and!development!program!the!company!has!commercialized!34!new!enzyme!products!called!CAZyme™!Carbohydrases!through!its!reagent!partner,!Lucigen!Corp.!Several!of!these!CAZymes!hold!promise!in!the!therapeutic!industry!in!fighting!infectious!diseases.!C5•6és!microbial!and!enzyme!technology!platform!has!been!developed!over!the!course!of!seven!years!using!US!Government!SBIR!grants!and!private!equity!investments.!C5•6!is!an!industrial!partner!of!the!University!of!Wisconsin’s!Great!Lakes!Bioenergy!Research!Center!funded!by!the!DOE.”!

Proucts:!

Cellulases!(34!enzymes)' !

! ! !!


Calzyme'Laboratories,'Inc.!

http://www.calzyme.com/!!

3443!Miguelito!Court!

San!Luis!Obispo,!CA!93401!

USA!

Tel:!+1:805:541:5754!

Tel:!+1:800:523:9127!

Fax:!+1:805:541:8301!!


NA!


Nearly!100%!

Enzyme!categories! Many!for!research!and!diagnostic!use!Expression!systems! Derived!from!animal!and!plant!tissue,!non:recombinant!Capacity/scale! Grams!to!kilograms.!!In:house!production.!!Key!People! Muzzafar!Iqbal,!PhD,!Founder!and!President;!Roger!Reapando,!Manager,!

Tuelake,!CA!site!Partnerships! NA!Customers! NA!Financial!Health! NA!Catalog!of!Enzymes! +++!Toll!Manufacturing! NA!!

Calzyme’s!website!states!that!it!is!a!manufacturer!of!enzymes,!proteins,!coenzymes,!subtrates,!and!related!biochemicals.!!An!online!catalog!with!a!large!product!range!is!listed!in!the!web!site.!The!Company!also!is!a!primary!producer!of!horse!radish!peroxidase!from!California:grown!horse:radishes!and!offers!bulk!quantities.!

Products:!

Calzyme!lists!about!100!enzymes!for!diagnostics!and!life!science!research!use.'

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Cambrex'

http://www.cambrex.com/!!!

One!Meadowlands!Plaza�!

East!Rutherford,!NJ!07073!!

USA!!

Tel:!+1:201:804:3000!

Tel:!+1:866:286:9133!!

Fax:!+1:201:804:9852!!



950!employees!

Company!type! Public:!CBM!Enzyme!sales!absolute!and/or!as!a!percentage!of!company!sales!

Small!

Enzyme!categories! NA!Expression!systems! NA!Capacity/scale! Pilot!scale!Key!People! Steven!M.!Klosk,!CEO!of!Cambrex;!Antje!Gupta,!Managing!Director!of!

Cambrex!IEP!subsidiary!in!Wiesbaden,!Germany!Partnerships! NA!Customers! Global!Financial!Health! +++!Catalog!of!Enzymes! NA!Toll!Manufacturing! +!!

Cambrex!is!a!global!life!science!company!that!offers!products!and!services!for!pharmaceutical!research,!development,!and!manufacture.!!It!has!operations!in!the!USA,!Sweden,!Italy,!and!Estonia.!!Cambrex!IEP!is!a!subsidiary!that!focuses!on!engineering,!selling,!and!using!enzymes!as!biocatalysts!in!pharmaceutical!manufacture.!!Though!it!does!not!sell!a!catalog!of!enzymes,!Cambrex!IEP!has!a!library!of!at!least!100!enzymes!(transaminases!and!reductases,!potentially!others)!that!it!screens!as!a!service,!and!can!then!provide!the!enzyme(s)!that!work!in!a!client’s!process!on!a!pilot!scale.!!

!

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Cellectis'

http://www.cellectis.com/!!

Biopark!

8!rue!de!la!Croix!Jarry!

75013!Paris!!

France!

Tel:!+33!(0)1!81!69!16!00!



220!employees!



Enzyme!categories! Life!science!tools!for!DNA!manipulation.!Expression!systems! NA!Capacity/scale! Lab!scale!Key!People! André!Choulika,!Chairman!and!CEO!Partnerships! NA!Customers! Global!Financial!Health! :!(additional!funding!needed!soon,!high!burn!rate)!Catalog!of!Enzymes! ++!Toll!Manufacturing! :!!

From!the!company!website:!“Cellectis!Group!is!a!worldwide!pioneer!and!leading!company!in!the!fields!of!genome!engineering!and!cell:based!therapies.!Based!on!a!unique!intellectual!property!portfolio,!Cellectis!has!developed!strong!expertise!in!technologies!enabling!precise!genome!modification!and!stem!cells!with!applications!ranging!from!cancer!immuno:therapy,!gene!therapy!to!regenerative!medicine.!The!Group!leads!collaborative!partnerships!with!pharmaceutical,!biotech!and!seed!companies.”!!

Products:!

Meganucleases!and!TALENs!(Transcription!activator:like!effector!nucleases),!and!kits!for!their!use.!

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CENTERCHEM'

http://www.centerchem.com/!!

20!Glover!Avenue!

Norwalk,!CT!06850!

USA!

Tel:!+1:203:822:9800!

Fax:!+1:203:822:9820!!


11:50!employees!


Small!portion!of!total!revenues.!!

Enzyme!categories! Food!enzymes.!Expression!systems! NA!Capacity/scale! Bulk.!!No!in:house!production.!Key!People! NA!Partnerships! NA!Customers! Global!Financial!Health! NA!Catalog!of!Enzymes! +!(small!selection)!Toll!Manufacturing! :!!

From!the!company!website:!“Centerchem!is!a!leading!international!supplier!and!marketer!of!quality!functional!ingredients!used!in!a!wide!range!of!industries.!Since!1948,!we!have!built!a!network!of!specialty!manufacturers!throughout!the!world,!as!well!as!unparalleled!internal!resources!including!a!highly!specialized!technical!personnel,!a!thorough!knowledge!of!transportation!regulations,!and!technical!market!research!and!promotional!expertise.!Together!with!the!numerous!technologies!to!which!Centerchem!has!access,!our!unique!capabilities!allow!us!to!provide!our!partners!with!the!highest!levels!of!support.!“!

Products:!

Invertase!

Pectinases!

Amylases! !

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Chematics,'Inc.'

http://www.chematics.com/!!

PO!Box!293!!

North!Webster,!IN!46555!

USA!

Tel:!+1:800:348:5174,!+1:574:834:2406!

Fax:!+1:574:834:7427!



Small!


Though!enzymes!are!in!most!of!the!kits!that!Chematics!offers,!only!one!enzyme!is!offered!on!its!own!and!makes!up!a!small!portion!of!revenues.!

Enzyme!categories! Diagnostic!Expression!systems! Pichia,pastoris,Capacity/scale! Kg!scale!Key!People! William!Woenker,!CEO!Partnerships! Sells!alcohol!oxidase!through!Sigma:Aldrich!Customers! NA!Financial!Health! NA!Catalog!of!Enzymes! +!!Toll!Manufacturing! :!!

From!the!company!website:!“Chematics!is!a!privately!held!biotechnology!company!engaged!in!the!development!and!manufacture!of!novel!in:vitro!diagnostic!testing!solutions!and!products!that!facilitate!early!identification!of!abnormal!or!unhealthy!conditions.!Founded!in!1988,!Chematics!is!located!in!North!Webster!Indiana.!Our!objective!as!a!company!is!to!provide!our!customers!worldwide!with!innovative!easy!to!use!products,!at!a!reasonable!price!that!are!of!the!highest!quality!and!are!safe!and!effective!when!used!for!the!purposes!for!which!they!are!intended.!Our!success!as!a!business!depends!upon!achievement!of!this!objective!and!upon!continuous!improvement!of!our!products,!processes!and!customer!experiences.”!

Products:!

Alcohol!Oxidase! !

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CHEMOS'GmbH'

http://www.chemos:group.com/!!

Werner:von:Siemens!Str.!3!

D:93128!Regenstauf!!

Germany!

Tel:!+49!9402!9336!0!

Fax:!+49!9402!9336!13!


Year!Founded! ca.!1988!Size!($!or!employee!count!or!both)!

NA!


Likely!very!low!

Enzyme!categories! A!random!selection!of!enzymes!from!outside!suppliers.!!!Expression!systems! None!Capacity/scale! NA.!!No!in:house!production.!Key!People! Ulrike!Lingner:Hoffmann,!CEO!Partnerships! CLEA!Technologies!supplies!some!of!the!enzyme!products.!Customers! Europe!Financial!Health! NA!Catalog!of!Enzymes! +!Toll!Manufacturing! :!!

From!the!company!website:!“CHEMOS!GmbH!is!a!solid!family:owned!enterprise!with!an!experience!of!25!years:!Emerged!from!a!chemical!laboratory,!grown!and!evolved!into!a!trading!company.!!Providing!a!special!service!in!trading,!we!do!not!synthesize!or!produce!any!goods.!Our!strength!lies!in!a!big!database!and!a!grown!worldwide!network.!!CHEMOS!GmbH!manages!import!and!export!of!rare!raw!materials!and!for!specially!synthesized!chemicals!that!are!difficult!to!procure.!!International!and!established!contacts!with!traders!and!producers!characterize!our!work.!We!are!proud!of!the!appreciative!confidence!of!our!long:term!costumers.!!CHEMOS!GmbH!is!a!specialty!trading!company!for!chemical!products!performing!worldwide.!We!supply!the!goods!to!support!your!research,!development!and!production!flow.!!More!than!180.000!articles!from!partners!from!all!over!the!world!are!ready!for!your!request.!!CHEMOS!GmbH!does!not!pursue!warehousing!and!keeps!only!a!few!goods!in!stock.”!

!

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Products:!

About!100!enzymes!including!

Lipases!

Glucose!oxidase!

Lactate!oxidase!


Ascorbate!oxidase!

Bilirubin!oxidase!

Chloroperoxidase!


Choline!oxidase!

Peroxidase!

DNA!ligase!

RNA!ligase!

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Chimab!

www.chimab.it!!

via!Colombo,!34!

35011!Campodarsego!(PD)!!

Italy!

Tel:!+39!049!9201496!

Fax:!+39!049!9201498!



Medium!sized!company!


Small!

Enzyme!categories! Food!processing.!Expression!systems! NA!Capacity/scale! Bulk.!!In:house!production!unclear.!Key!People! Giorgio!Agostini,!owner!Partnerships! NA!Customers! Europe,!Russia.!Financial!Health! NA!Catalog!of!Enzymes! +!Toll!Manufacturing! :!!

From!the!company!website:!“Chimab!has!been!a!partner!of!the!Italian!and!international!food!industries!since!1985!through!the!supply!of!functional!food!ingredient!solutions,!distribution!of!ingredients!and!production!of!functional!semi:finished!products!combined!with!consultancy!and!application!assistance!services!dedicated!to!its!clients.”!

Products:!

Phospholipases!

Transglutaminase!

Baking!and!flour!enzymes.! !

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!

Chiral'Vision'

http://www.chiralvision.com/!!

J.H.!Oortweg!21!

2333!CH!Leiden!

The!Netherlands!

Tel:!+31!71!332!2124!

Tel:!+31!64!603!8991!!

Fax:!+31!71!332!2125!

Fax:!+31!84!758!7301!



NA!


Large!portion!of!revenues!

Enzyme!categories! Immobilized!versions!of!commercial!and!proprietary!enzymes,!including!in!kit!format!of!wide!range!of!enzymes!for!biocatalysis!applications.!

Expression!systems! None!Capacity/scale! Sells!batches!of!up!to!10!Kg!Key!People! Dr.!Rob!Schoevaart,!CEO!Partnerships! Purchases!enzymes!from!c:LEcta,!Novozymes,!Amano,!Meito,!Sigma,!DSM,!

etc.!Customers! Global.!!Distributes!through!Ryan!Scientific,!Austin!Chemical!Company,!and!

Syncozymes.!Financial!Health! ++!(profitable,!25%!annual!growth!rate)!Catalog!of!Enzymes! +++!(extensive!collection!of!biocatalysts!for!fine!chemical!processes)!Toll!Manufacturing! +!!

Chrial!Vision!specializes!in!immobilizing!enzymes.!!The!company!sells!immobilized!enzymes!both!in!kit!and!individual!form,!and!additionally!immobilizes!enzymes!for!customers!on!a!service!basis.!!The!company!also!will!do!chemical!process!development!using!its!enzymes!as!a!service.!!Instead!of!expressing!and!producing!its!own!enzymes,!Chiral!Vision!purchases!the!soluble!enzyme!products!of!

! ! !!


other!suppliers!and!does!the!immobilization!in!house.!!The!company!also!sells!chiral!intermediates!that!it!makes!with!its!enzymes,!and!the!beads!that!it!uses!for!immobilization.!

Key!Enzyme!Products!(All!Immobilized!Versions):!

Aldolase!(DERA)!

Amidase!

D:amino!acid!dehydrogenase!

Cytochrome!P450!Monooxygenase!

Ene!reductase!

Epoxide!hydrolase!

Esterase!PLE!(microbial!pig!liver!esterase)!

Formate!Dehydrogenase!(FDH)!

Glucose!Dehydrogenase!(GDH)!

Ketoreductase!(KRED)!

D:Lactate!dehydrogenase!nicotinamide!

Leucine!dehydrogenase!

Lipase!

Nicotinamide!mononucleotide!adenylyltransferase!

NAD!Kinase!

Nitrilase!

Nitrile!hydratase!

Nitro!Reductase!

Oxynitrilase!!

Penicillin!G!amidase!

Phospholipase!

Protease!

ω:Transaminase! !

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!

Chr.'Hansen'

http://www.chr:hansen.com/!!

Bøge!Allé!10:12!

DK:2970!Hørsholm!

Denmark!

Tel:!+45!45!74!74!74!

Fax:!+45!45!74!88!88!


2,500!employees!

Company!type! Public:!CHR!Enzyme!sales!absolute!and/or!as!a!percentage!of!company!sales!

Small!

Enzyme!categories! Dairy!enzymes.!Expression!systems! Kluyveromycis,lactis,!other!fermentation!microbes,!and!extraction!from!egg!

whites!and!animal!tissue.!Non:recombinant!products!only.!Capacity/scale! Multi:ton!Key!People! Cees!De!Jong,!CEO;!Knud!Vindfeldt,!Exec.!VP!Cultures!and!Enzymes!Partnerships! Partnered!with!Novozymes!for!some!enzyme!projects,!Novo!owns!a!minority!

share!Customers! Global!Financial!Health! +++!Catalog!of!Enzymes! ++!Toll!Manufacturing! :!!

Chr.!Hansen!is!an!ingredients!company!and!supplies!its!products!to!the!food,!beverage!(especially!dairy),!and!animal!nutrition!industries.!!The!company!specializes!in!non:recombinant!enzymes!for!the!food!industry.!

Products:!

Lactase,!Rennet,!Chymosin,!Lipases,!Lysozyme,!Phospholipase,!Novel!lactose:to:lactobionic!acid!enzyme!

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CHT/BEZEMA'

http://www.cht:group.com/!!

CHT!R.!BEITLICH!GMBH!

Bismarckstr.!102!

72072!Tübingen!

Germany!

Tel:!+!49!(0)!7071/154!:!0!

Fax:!+!49!(0)!7071/154!:!290!



1,600!employees!

Company!type! Private!family!owned!Enzyme!sales!absolute!and/or!as!a!percentage!of!company!sales!

Small!

Enzyme!categories! Textile!treatment.!!!Expression!systems! NA!Capacity/scale! Bulk.!!In:house!production!likely.!Key!People! Bernhard!Hettich,!Erich!Mechel,!Managing!Directors!Partnerships! NA!Customers! Global!Financial!Health! +++!Catalog!of!Enzymes! +!Toll!Manufacturing! :!!

CHT/Bezema!is!a!conglomerate!of!many!companies!with!four!specific!divisions:!textiles,!textile!care,!construction,!and!performance!chemicals.!!In!textiles,!the!company!offers!enzymes!for!desizing.!

Products:!

Amylases!

Pectinases!

Hemicellulases!

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Clea'Technologies'BV!

www.cleatechnologies.com!!

Delftechpark!34!

2628!XH!Delft!

The!Netherlands!

Tel:!+31!(0)15!7600!300!

Fax:!+31!(0)15!7600!301!



11:50!employees!


100%!of!revenues!from!immobilized!enzyme!sales,!custom!R+D,!and!consulting.!

Enzyme!categories! Immobilized!enzymes!created!by!the!CLEA!technique:!Cross:Linked!Enzyme!Aggregates.!!!

Expression!systems! NA!Capacity/scale! Small!scale!Key!People! Roger!A.!Sheldon,!CEO!and!President!Partnerships! NA!Customers! CO2!Solutions!employed!the!services!of!CLEA!to!immobilize!carbonic!

anhydrase!enzymes.!Financial!Health! ++!(estimated)!Catalog!of!Enzymes! ++!Toll!Manufacturing! +!(Enzymes!worked!on!in!the!past!include!hydrolases,!penicillin!G!acylases,!

lipases,!esterases,!proteases,!nitrilases,!aminoacylase,!phytase,!galactosidase,!carbonic!anhydrase,!oxidoreductases,!KREDs,!FDH,!glucose!oxidase,!galactose!oxidase,!amino!acid!oxidase,!laccase,!catalase,!chloroperoxidase,!HRP,!lyases,!nitrile!hydratases,!PDC,!DERA,!nitrile!hydratase,!transferases,!and!transaminases.)!

!

CLEA!is!an!acronym!for!cross:linked!enzyme!aggregates,!which!are!the!product!that!the!company!offers.!!The!company!offers!a!selection!of!immobilized!enzyme!products,!and!additionally!offers!custom!immobilization!of!enzymes!and!contract!research!to!develop!biocatalytic!processes!using!immobilized!enzymes.!!The!company!also!offers!a!selection!of!soluble!enzymes.!!!

!

! ! !!


Products:!

Lipases!(about!10!immobized!lipases!and!20!soluble!lipases)!

Proteases!(7!immobilized!proteases!and!about!10!soluble!proteases)!

Nitrile!hydratase!

Amidases!(soluble!and!immobilized)!

Hydroxyl!nitrilase!!!

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!

cBLEcta'GmbH'

http://www.c:lecta.com/!!

Perlickstraße!5!

04103!Leipzig!

Germany!

Tel:!+49:341:3552140!

Fax:!+49:341:35521433!

Email:!contact@c:LEcta.com!!!


About!50!employees!


Most!revenues!are!from!partnerships,!enzymes!are!a!minority!portion.!

Enzyme!categories! Biocatalysis,!molecular!biology.!Expression!systems! Proprietary!strains!of!E.,coli,,Pichia,,and!Bacillus.!Capacity/scale! Pilot!scale!Key!People! Marc!Struhalla,!Managing!Director!(CEO)!and!Co:Founder;!Dr.!Andreas!

Buthe,!Business!Development!Manager;!!Partnerships! Current!and!past!partners!and!customers!include!Chiral!Vision,!AquaPharm,!

Clariant,!Sartorius!Stedim!Biotech,!Acoris!Research,!Symrise,!Henkel,!and!Cognis.!!!

Customers! Global!Financial!Health! ++!Catalog!of!Enzymes! ++!Toll!Manufacturing! +!!

c:LEcta’s!business!includes!both!offering!enzymes!for!sale!and!engaging!in!biocatalyst!development!partnerships.!!The!company!has!formed!and!seeks!partnerships!with!other!companies!to!develop!enzymes!for!a!wide!range!of!applications!including!fine!chemicals,!food!and!feed,!life!science!tools,!textiles,!detergents,!biofuels,!and!green!chemicals.!!c:LEcta!has!collections!of!environmental!DNA!as!well!as!5000!strains!of!microbes!that!serve!as!a!starting!point!for!its!research!efforts.!!Using!its!Cluster!Screening!technique,!it!can!evaluate!in!excess!of!a!million!samples!per!day!in!high:throughput!format.!!Further!development!of!promising!enzymes!is!done!by!directed!evolution!and!expression!development.!!

! ! !!


The!company!has!done!strain!engineering!for!efficient!enzyme!production!using!proprietary!strains!of!E.,coli,,Pichia,,and!Bacillus.!

Products:!

Theroactive!and!thermostable!asparaginase!(prevention!of!acrylamide!formation!in!cooked!foods)!

CAL!B!Lipase!

Serratia!nuclease!

RNase!T2!

Screening!sets!of!enzymes!in!various!categories,!including!!

Transaminases!

Ketoreductases!

Lipases!and!esterases!

!

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Codexis'

www.codexis.com!!

200!Penobscot!Drive!

Redwood!City,!CA!94063!

USA!

Tel:!+1:650:421:8100!



147!employees,!$35!million!to!$40!million!revenues!for!FY!2013.!

Company!type! Public,!stock!symbol!CDXS,!trades!on!NASDAQ!exchange!in!USA!Enzyme!sales!absolute!and/or!as!a!percentage!of!company!sales!

65:70%!

Enzyme!categories! Pharmaceutical!and!biocatalysis!enzymes,!industrial!enzymes!(cellulases)!biofuel!and!bio:based!chemicals.!

Expression!systems! Standard!hosts!like!E.,coli,,Pichia,,Trichoderma,,and!Bacillus,!and!additionally!the!C1!organism!under!license!from!Dyadic!

Capacity/scale! Pilot!scale!in!house,!multi:ton!scale!via!partnership!Key!People! John!Nicols,!CEO;!Peter!Seufer:Wasserthal,!Sr.!VP,!Pharmaceuticals;!Matt!

Tobin,!Sr.!VP,!R!&!D!Partnerships! Chemtex!for!detergent!alcohols!business,!Lactosan!GmbH!for!enzyme!

production,!Strem!for!product!distribution,!Ampac!and!AMRI!for!fine!chemicals,!Arch!for!intermediates!production,!cellulase!platform!licensed!from!Dyadic,!Purolite!for!enzyme!immobilization!

Customers! Merck,!Pfizer,!GSK,!Teva,!Roche!and!a!total!of!more!than!50!companies!!Financial!Health! Not!yet!profitable,!$30!million!cash!reserves,!burn!rate!of!about!$15!million!

per!year.!Catalog!of!Enzymes! ++!(formerly!offering!an!extensive!catalog,!Codexis!now!mostly!offers!

enzyme!kits!and!customized!biocatalysis!solutions)!Toll!Manufacturing! :!!

Codexis!was!founded!in!2002!as!a!spin!out!company!from!Maxygen!in!order!to!commercialize!Maxygen’s!DNA!shuffling!platform!for!biocatalytic!applications.!!The!company!offers!enzymes!both!in!kit!format!for!screening!and!as!individual!enzymes.!!The!enzymes!are!derived!mostly!via!directed!evolution!to!give!selections!of!enzymes!with!improved!properties.!!Many!of!the!enzymes!are!developed!for!commercial!applications!and!are!therefore!stabilized!for!production!processes.!!Codexis!also!works!with!customers!to!develop!custom!enzymes!and!biocatalytic!routes!as!a!service,!and!generally!provides!the!enzymes!afterwards!and/or!collects!royalties!on!commercial!processes.!

! ! !!


From!2006!to!2012,!the!company!had!a!major!collaboration!with!Royal!Dutch!Shell!which!was!terminated!in!2012.!!The!collaboration!provided!funding!to!Codexis!to!develop!biofuels!and!realted!enzymes.!!Codexis!has!developed!its!cellulase!enzymes,!trade!named!CodeXyme.!!Codexis!has!licensed!the!C1!expression!and!production!system!from!Dyadic.!Additionally,!Codexis!has!been!developing!a!process!to!produce!long:chain!alcohols!by!fermentation.!!The!long:chain!alcohol!product!is!called!CodeXol®.!!The!CodeXol®!project!is!being!scaled!up!in!Italy!in!collaboration!with!Chemtex,!and!a!demonstration!plant!was!in!initial!phases!of!testing.!!This!plant!uses!a!process!that!first!degrades!cellulose!using!Codexis’!cellulase!enzymes,!(CodeXyme®),!and!then!ferments!the!resulting!sugar!to!produce!CodeXol®.!!As!of!late!2013!further!internal!development!of!CodeXol®!has!been!stopped.!

Codexis!recently!announced!that!it!is!expanding!its!focus!to!therapeutic!proteins,!and!will!attempt!to!partner!in!this!area.!!Other!applications!in!which!Codexis!is!active!are!agriculture,!cosmetics,!and!food.!!

Products!(sold!individually!and!in!screening!kit!format):!

Ketoreductases!

Transaminases!

Amine!oxidases!

Ene!reductases!

Nitrilases!

Halohydrin!dehalogenases!

Baeyer:Villiger!mono:oxygenases!

P450!enyzmes!derived!from!BM3!(CYP102A1)!

!

!

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Colotex'BioBTechnology'Co.'Ltd.'

http://www.colotexbiotech.com/!!

Unit!2,!10/E!

Siu!Wai!Industrial!Bldg!

29:33!Wing!Hong!St.!

Cheung!Sha!Wan!Kln!

Hong!Kong!

Tel:!+852:22426933!

Fax:!+852:22426932!


NA!


Majority!of!revenues!

Enzyme!categories! Bio:diesel,!textiles,!feed,!food.!!!Expression!systems! NA!Capacity/scale! Bulk.!In:house!production.!Key!People! NA!Partnerships! NA!Customers! NA!Financial!Health! NA!Catalog!of!Enzymes! ++!Toll!Manufacturing! :!!

Colotex!is!a!manufacturer!and!supplier!of!enzymes!for!applications!in!textiles,!feed,!and!food.!

Products:!

Alpha:amylases,!Cellulase!

Catalase,!Laccase!

Phytase,!Xylanase!

Glucoamylase,!Beta:amylase,!Pullulanase!

'

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Concord'Biotech,'Ltd.'

http://www.concordbiotech.com/!!

B:1002,!Safal!Pegasus!

10th!Floor,!Nr.!Prahladnagar!Garden!

100ft!Road,!Satellite!Road!!

Ahmedabad:380015!Gujarat!

India!

Tel:!+91!79!40321179!



501:1000!


Small!sales!of!enzymes.!!Mostly!focused!on!APIs!and!intermediates.!

Enzyme!categories! Penicillin:G!Amidase!Enzyme!(Biocatalyst!for!6:APA,!7:ADCA!&!other!semi:synthetic!β:lactams)!

Expression!systems! NA!Capacity/scale! NA!Key!People! Sudhir!Vaid!is!the!MD!and!CEO!Partnerships! NA!Customers! Global!Financial!Health! NA!Catalog!of!Enzymes! +!Toll!Manufacturing! :!!

In!2000,!this!company!was!split!off!from!DSM.!!It!is!mainly!focused!on!fermentive!production!of!APIs!and!intermediates!for!pharmaceuticals.!!“The!fermentation!plants!have!a!total!capacity!of!about!450m3!along!with!the!supporting!equipments.!The!entire!facility!has!an!automated!control!system!which!is!monitored!and!controlled!by!the!expert!support!team!of!microbiologist,!biochemical!engineers,!chemists!etc.”!

Products:!

Penicillin:G!Amidase!

! !

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!

Condor'Specialty'Products'

http://www.condorspecialty.com/!!

6.LANGFORE!LANE!

LADERA!RANCH!CA!92694!!

USA!!

Tel:!+1:770:277:0024!

Tel:!+1:949:4298776!!

Fax:!+1:949:4298784!!

Email:!cspı[email protected]!!!

Email:[email protected]!!!!


NA!


Small!

Enzyme!categories! Textile!enzymes.!!!Expression!systems! NA!Capacity/scale! Bulk.!In:house!production!not!likely.!Key!People! Taskin!Altug,!Owner.!Partnerships! NA!Customers! NA!Financial!Health! NA!Catalog!of!Enzymes! +!Toll!Manufacturing! :!!

From!the!company!website:!“Condor!Specialty!Products!is!an!american!company!established!in!Georgia!since!1997.!We!are!manufacturing!and!formulating!chemical!products!used!in!Denimwash!and!Textile!industries.”!

Products:!

Laccase!

Cellulase! !

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CPC'Biotech!

www.cpcbiotech.it!!

Via!dei!Mille,!74!!

80121!Napoli!

Italy!

Tel:!+39!(039)!6898029!

Fax:!+39!(039)!6899774!



Small!to!medium!sized!organization.!


Likely!significant!portion.!

Enzyme!categories! Biocatalysis,!diagnostics.!Expression!systems! E.,coli,,Bacillus,!and!many!non:disclosed!microorganisms.!Capacity/scale! Production!scale,!up!to!130,000!L!fermentations!Key!People! Fabio!Arenghi,!President!Partnerships! NA!Customers! NA!Financial!Health! ++!(estimated)!Catalog!of!Enzymes! ++!Toll!Manufacturing! ++!(expression!and!production,!also!immobilization)!!

CPC!Biotech!is!both!a!producer!of!enzymes!for!sale!and!a!contract!organism!for!enzyme!R+D!and!production.!!The!company!was!spun!out!from!an!antibiotics!producer,!and!therefore!is!closely!associated!with!the!pharmaceutical!industry.!The!company!does!extensive!contract!manufacturing!oif!enzymes!for!various!companies.!

The!list!of!enzyme!products!is!extensive!and!includes!the!following:!6:phospho:D:gluconate!dehydrogenase!6:phospho:D:glucose!isomerase,!Acetate!kinase!(High!specificity!for!Acetate),!Acetyl!CoA!Synthetase!(high!stability!Lyophilized),!Acetyl!CoA!Synthetase!(high!stability),!Acetyl!esterase!(Immobilized),!Acetyl!esterase!(Lyophilized),!Acetyl!esterase!(Solution),!Acid!Phosphatase,!Alpha!fucosidase,!Alpha:xylosidase,!B:Galactosidase,!Cephalosporinase!(Low!Concentration),!Cephalosporinase!(β:lactamase!type!II),!Citrate!Synthase!(High!Stability),!D:Amino!Acid!Oxidase,!D:Lactate!Dehydrogenase,!D:Malate!Dehydrogenase,!Gluconate!Kinase,!Glucose!6!Phosphate!Dehydrogenase,!Glutamate!Dehydrogenase,!Glutamate!Oxaloacetate!Transaminase,!Hexokinase,!Invertase!(beta:fructofuranoside)!

! ! !!


NEUTRAL,!L:Lactate!Dehydrogenase,!L:Malate!Dehydrogenase,!Penicillin!Acylase,!Penicillinase!(β:lactamase!type!I),!Penicillinase!MP!(low!concentration),!Penicillinase!N!(low!concentration),!Pyruvate!Kinase!(High!Stability).!

!

!

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CreativeBiomart'

www.creativebiomart.net!!

45:16!Ramsey!Road!

Shirley,!NY!11967!

!USA!

Tel:!+1:631:559:9269!!

Fax:!+1:631:938:8127!!

Email:!info@creative:biomart.com!!


51:200!employees!


Likely!small!

Enzyme!categories! Diagnostics,!food,!feed,!brewing,!pulp!and!paper,!textiles,!leather,!waste!management,!animal!feed,!leather.!!!

Expression!systems! E.,coli!and!others!Capacity/scale! Lab!scale!and!bulk.!!In:house!production!unlikely!for!bulk!enzymes.!Key!People! NA!Partnerships! ProteoGen!distributes!CD!Biomart’s!products!in!India.!Customers! Global.!Financial!Health! ++!(estimate)!Catalog!of!Enzymes! ++!Toll!Manufacturing! +!(small!scale)!!

Creative!BioMart!primarily!offers!antibodies,!enzymes,!cell!lines,!and!ELISA!kits,!along!with!some!services!for!using!these!products.!

Products:!

Peroxidase!

Uricase!

Catalase!

Glycerol!kinase!

Glucose!oxidase!

! ! !!


Mannase!

Phytase!

Glucanase!

Cellulases!

Pectinases!

Proteases!

Amylases!

Xylanases!


Purine!nucleotide!phosphorylase!

3:hydroxysteroid!dehydrogenase!


Adenosine!aminohydrolase!

Adenosylhomocysteinase!

Bromelain!

!

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Deltagen'Bioproducts'N.A.'

http://deltagenbiop.com/!!

Marsweg!6!

P.O.!Box!3444!

Curaçao!

Netherlands!Antilles!!

Tel:!!+599!9!!737!–!6411,!!+599!9!!737!:!6166!

Fax:!+599!9!!737!:!8892!


Small!


Small!

Enzyme!categories! Dairy,!oil!processing,!meat!processing,!agriculture,!baking,!and!beverages.!!!Expression!systems! NA!Capacity/scale! Bulk.!!No!in:house!production.!Key!People! Jaap!Luursema,!Owner!and!General!Manager!Partnerships! Deltagen!is!a!distributor!for!WeissBiotech!which!is!in!turn!a!distributor!for!

enzymes!from!Verenium.!!Other!suppliers!include!Agargel,!Arla!Foods,!Biocon!del!Peru,!Edicas,!Fibran,!Haifa,!IOI!Group!Loaders!Croklan,!Kerry!Foods,!KMC,!Malasian!Food!Industries!A.S.,!Nowicki,!Productos!Bixa,!Tereos,!TFI,!Usitecnica,!Vikan!Advancing!Hygienig!Cleaning.!

Customers! South!America,!Columbia.!Financial!Health! NA!Catalog!of!Enzymes! +!Toll!Manufacturing! :!!

Deltagen!is!a!distributor!of!ingredients!in!South!America.!!!

Products:!

Transglutamase,!Amylases,!Cellulases,!Oxidases,!Proteases,!Phospholipases!

!

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DIREVO'Industrial'Biotechnology'GmbH'

www.direvo.com!!

Nattermannallee!1!

50829!Köln!(Cologne)!

Germany!

Tel:!+49!221:47448:0!

Fax:!+49!221:47448:111!



40!employees!


NA!

Enzyme!categories! Lignocellulosic!material:degrading!enzymes!Expression!systems! NA!Capacity/scale! NA!Key!People! Jörg!Riesmeier,!CEO!Partnerships! Direvo!has!sold!a!mannase!business!to!BASF,!and!is!collaborating!with!BASF!

on!the!development!of!a!protease!for!animal!feed.!Customers! NA!Financial!Health! +!(Prominent!investments!by!venture!funds,!revenues!from!sales!to!and!work!

with!BASF)!Catalog!of!Enzymes! +!(only!one!offering!so!far)!Toll!Manufacturing! :!!

Direvo!works!on!enzymes!that!degrade!lignocellulosic!material!and!the!distillers!grains!left!over!from!biofuel!and!biochemical!fermentations.!!It!has!sold!one!enzyme!project!to!BASF,!and!has!partnered!with!them!on!a!protease!for!animal!feed.!!The!company!is!also!involved!in!consolidated!bioprocessing,!and!it!has!produced!lactic!acid!from!a!cellulosic!feedstock!using!this!technology.!

From!the!company!website:!“Direvo!Industrial!Biotechnology!GmbH!(Direvo!IBT)!was!founded!in!2008!by!the!shareholders!of!its!mother!company,!Direvo!Biotech!AG,!which!had!been!acquired!by!Bayer!Healthcare!for!$300!million.!!Direvo!Biotech!AG!commenced!operation!in!2000!as!one!of!the!world’s!leading!developers!of!directed!evolution!technologies.!Many!times,!over!the!years,!its!proprietary!evolution!platform!has!demonstrated!the!outstanding!ability!to!develop!tailored!enzymes!for!both!health!care!and!industrial!applications.!!Direvo!IBT!retained!all!rights!to!the!directed!evolution!

! ! !!


technology!and!intellectual!property!for!application!in!non:pharmaceutical!industries!and!became!fully!operational!in!early!2009!in!its!state:of:the:art!laboratories!in!Cologne.!!Since!then!we!are!deploying!a!decade!of!enzyme,!microbe!and!process!know:how!to!develop!bio:based!solutions!for!our!partners!and!customers!in!the!clean!energy,!clean!chemistry!and!biomass!conversion!markets.”!

Participants!in!funding!rounds!has!included!TVM!V!Life!Science!Ventures!GmbH!&!Co.!KG,!Munich,!NRW.Bank!Venture!Fonds!GmbH!&!Co.!KG,!Düsseldorf,!Sparkasse!Köln:Bonn!mbH,!Cologne,!Mulligan!BioCapital,!Hamburg,!Danisco!Venture!ApS,!Copenhagen,!and!several!private!investors.!

Product:!

Sells!BluZy®:D,!which!is!an!enzyme!that!improves!the!digestibility!of!distillers!grain!for!use!as!feed!for!non:ruminant!animals.!!This!may!be!a!phytase.!!The!company!is!also!developing!cellulase!enzymes.!

!

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Discovery'Biocatalysts'Limited'

http://www.discovery:bc.co.uk/!!

5!Leslie!Avenue!

Bury!BL9!8DL!

UK!!

Tel:!+44!(0)!7904195605!



1:5!employees!

Company!type! Private!non:profit!Enzyme!sales!absolute!and/or!as!a!percentage!of!company!sales!

100%!

Enzyme!categories! Biocatalysis!Expression!systems! E.,coli,Capacity/scale! Lab!scale!Key!People! Gareth!DeBoos,!Director!of!Discovery!and!Managing!Director!Partnerships! Most!biocatalysts!are!from!the!lab!of!Prof.!Nicholas!J.!Turner!at!the!

University!of!Manchester!Customers! Global!Financial!Health! NA!Catalog!of!Enzymes! ++!Toll!Manufacturing! +!(only!small!amounts,!outsources!to!Biocatalysts!Ltd!for!larger!scale)!!

Discovery!Biocatalysts!is!a!non:profit!organization!with!the!goal!of!getting!biocatalysts!into!the!hands!of!R+D!professionals!as!quickly!as!possible!without!any!intellectual!property!concerns.!!The!organization!expressly!disavows!collecting!royalties,!stating!that!it!simply!sells!kits!and!will!tell!customers!the!identity!of!the!enzymes!so!that!the!customer!may!scale!up!and!develop!them!as!they!see!fit.!!Discovery!is!seeking!additional!enzymes!from!academic!labs!that!it!can!offer!in!kit!format.!!!

Products:!

Monoamine!oxidases,!kit!of!10.!!!

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DNA'Polymerase'Technology,'Inc.'

www.klentaq.com!!

1508!South!Grand!Blvd.!!

St.!Louis,!Missouri!63104!!

USA!

Tel:!+1:314:680:0575!!

Fax:!+1:314:754:9556!!



About!5:20!employees!


Significant!revenue!stream!

Enzyme!categories! Enzymes!for!DNA!modification.!!Polymerases.!Expression!systems! NA!Capacity/scale! Laboratory!research!scale!Key!People! John!Hartman,!Business!Manager;!Wayne!M.!Barnes,!President!and!Founder!Partnerships! NA!Customers! NA!Financial!Health! NA!Catalog!of!Enzymes! ++!Toll!Manufacturing! :!!

DNA!Polymerase!Technology!was!created!by!Wayne!M.!Barnes,!a!professor!at!Washington!University!in!St.!Louis.!!The!company!sells!DNA!polymerases!and!molecular!biology!kits!containing!the!enzymes.!

Products:!

DNA!polymerase!and!kits!thereof!

!

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Dong'Nam'Chemicals&'Equipments'Corporation'

www.dongnamlab.com!!!

33/8!Luu!Nhan!Chu!Str.!

Ward!5,!Tan!Binh!Dist.,!HCM!City!

Vietnam!

Tel:!(+84.8)!6292.3745!:!6292.3731!:!6292.3773!

Fax:!(+84.8)!6292.3750!



NA!


Small!

Enzyme!categories! Diagnostics!and!carbohydrate!modification!Expression!systems! NA!Capacity/scale! Lab!scale.!No!in:house!production.!Key!People! NA!Partnerships! NZYTech!Customers! Local!Financial!Health! NA!Catalog!of!Enzymes! +!Toll!Manufacturing! :!!

Dong!Nam!sells!a!wide!variety!of!scientific!equipment!and!reagents,!including!a!selection!of!enzymes!from!NZYTech.!

From!the!website:!“Dong!Nam!Chemicals&!Equipments!Corporation!supply!and!installation!of!equipment!:!scientific!instruments,!consumables,!chemicals,!Culture!Media,!Reagents!for!laboratories!in!the!Healthcare,!Education,!Research,!Enviroment,!Production!(Pharmaceutical,!Food!&!Beverage,!Fishery),!Center!of!!Analytical!Service!and!Government.”!


Carbohydrate:active!enzymes:!feruloyl!esterase,!glucomannan!acetyl!esterase,!pectin!acetyl!esterase,!xylan!acetyl!esterase,!arabinofuranosidase,!arabinoxylanase,!β:1,4:Glucosidase,!cellobiohydrolase,!chitinase,!cellulases,!β:1,3(4):glucanase,!β:1,3:glucanase,!endo:β:1,4:galactanase,!endo:β:1,4:

! ! !!


galactanase,!exo:β:1,3:galactanase,!exo:β:1,4:mannanase,!mannanase,!endo:β:1,4:mannanase,!mannosidase,!xylanase,!xyloglucanase,!α:galactosidase.!

Analytical!enzymes:!acetyl:CoA!syntethase,!D:alanine!aminotransferase!alcohol!dehydrogenase,!aldehyde!reductase,!arginase,!aspartate!aminotransferase,!citrate!synthase,!glucokinase,!glucose:6:phosphate!dehydrogenase,!glucose:6:phosphate!isomerase,!glutamate!dehydrogenase,!glutaminase,!lactadehyde!dehydrogenase,!D:lactate!dehydrogenase,!D:malate!dehydrogenase,!L:malate!dehydrogenase,!NADH!peroxidase,!sulfite!oxidase.!

!

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DSM'

http://www.dsm.com/!!

Het!Overloon!1!

6411!TE!Heerlen!

The!Netherlands!

Tel:!+31!(0)45!578!8111!


23,500!employees!

Company!type! Public:!DSM!Enzyme!sales!absolute!and/or!as!a!percentage!of!company!sales!

Significant!minority!revenue!stream!

Enzyme!categories! Biofuels,!baking,!brewing!and!winemaking,!dairy,!egg!processing,!fruit!processing,!animal!feed.!

Expression!systems! Many!Capacity/scale! Multi:ton.!!In:house!production.!Key!People! Feike!Sijbesma,!CEO!Partnerships! Novozymes!and!DSM!co:manufacture!and!co:market!some!animal!feed!

enzymes.!!Partnered!with!Codexis!for!access!to!biocatalysts!for!DSM’s!biocatalyst!route!development!and!manufacturing!services.!!Partnered!with!POET!to!use!DSM’s!cellulase!package!in!a!second:generation!bioethanol!plant.!Partners!with!Almac!to!offer!biocatalysis!screening!and!enzymes.!

Customers! Global!Financial!Health! ++!Catalog!of!Enzymes! +++!Toll!Manufacturing! :!!

DSM!is!a!conglomerate!that!has!a!leading!presence!in!the!enzyme!manufacturing!industry!in!food!and!feed!applications.!!Through!its!partnership!with!Novozymes!on!the!Ronozyme!family!of!phytases,!proteases,!and!carbohydrate:degrading!enzymes,!it!is!a!leader!in!animal!feed!additives.!!The!company!has!developed!a!cellulase!platform!for!second:generation!biofuels.!!DSM!also!uses!enzymes!as!biocatalysts!internally!for!the!manufacture!of!pharmaceutical!small!molecules.!!Notably,!the!company!has!developed!the!recombinant!expression!of!pig!liver!esterase!(PLE),!and!the!recombinant!source!of!the!enzyme!allows!it!to!be!a!Kosher!non:animal:derived!product.!!The!so:named!Pharma!PLE!is!thus!valuable!for!drug!manufacture,!which!DSM!is!willing!to!conduct!in!house!on!a!service!basis.!!DSM!has!collections!of!thousands!of!other!enzymes!as!well!which!it!uses!to!develop!routes!for!small!molecule!production!in!house!or!on!a!service!basis.!

! ! !!


From!the!company!website:!“Royal!DSM!N.V.!creates!solutions!that!nourish,!protect!and!improve!performance.!Its!end!markets!include!human!and!animal!nutrition!and!health,!personal!care,!pharmaceuticals,!automotive,!coatings!and!paint,!electrical!and!electronics,!life!protection!and!housing.!DSM!manages!its!business!with!a!focus!on!the!triple!bottom!line!of!economic!performance,!environmental!quality!and!social!responsibility,!which!it!pursues!simultaneously!and!in!parallel.!DSM!has!annual!net!sales!of!about!€8!billion!and!employs!some!22,700!people!worldwide.!The!company!is!headquartered!in!the!Netherlands,!with!locations!on!five!continents.”!

Products:!

Cellulases!

Proteases!

Xylanases!

Beta:glucanases!

Phytases!

Amylases!

Hemicellulases!

Pectinases!

!

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DuPont'

http://www.dupont.com/!!

1007!Market!Street!

Wilmington,!DE!19898!

USA!

Tel:!+1:302:774:1000!


70,000!employees!

Company!type! Public:!DD!Enzyme!sales!absolute!and/or!as!a!percentage!of!company!sales!


Enzyme!categories! Textiles,!detergents,!pulp!and!paper,!food,!baking,!winemaking,!brewing,!carbohydrate!processing,!biofuels,!animal!nutrition,!dairy,!oil!processing,!etc.!

Expression!systems! Many!Capacity/scale! Multi:ton.!In:house!production.!Key!People! Ellen!J.!Kullman,!CEO!Partnerships! Numerous.!!Partners!with!DSM!in!animal!nutrition!enzymes.!Customers! Global!Financial!Health! +++!Catalog!of!Enzymes! +++!Toll!Manufacturing! :!!

DuPont!is!a!large!conglomerate!involved!in!the!manufacture!of!specialty!chemicals!and!materials.!!The!company!entered!the!enzyme!space!in!2011!with!its!purchase!of!Danisco.!!DuPont!considers!the!enzyme!business!to!be!a!high:growth!industry,!and!has!been!hiring!strongly!in!research!supporting!its!commercial!offerings.!!The!company!has!a!strong!catalog!of!a!range!of!industrial!enzymes,!and!sells!through!distributors!worldwide.!!DuPont!also!has!one!of!the!leading!cellulase!enzyme!packages!for!second:generation!biofuels!production.!!

Products:!

Extensive!product!line!across!the!following!categories:!

Cellulases!

Proteases!

Xylanases!

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Beta:glucanases!

Phytases!

Amylases!

Hemicellulases!

Pectinases!

Lipases!

!

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Dyadic'International'Inc.'

http://dyadic.com/!!

140!Intracoastal!Pointe!Drive!

Suite!404!

Jupiter,!FL!33477:5094!

USA!

Tel:!+1:561:743:8333!

Fax:!+1:561:743:8343!



38!employees,!about!$15!million!annual!revenues!

Company!type! Public:!DYAI!Enzyme!sales!absolute!and/or!as!a!percentage!of!company!sales!

Revenues!from!(1)!licensing!its!patented!and!proprietary!technologies;!(2)!selling!its!proprietary!enzymes;!and!(3)!conducting!R&D!activities!for!third!parties.!

Enzyme!categories! Pulp!and!paper,!textiles,!food!and!beverage,!biomass!processing.!Expression!systems! Trichoderma!and!proprietary!C1!fungal!strains!(Myceliopthora,thermophila)!Capacity/scale! Access!to!a!150,000!L!fermentor!Key!People! Mark!A!Emalfarb,!Chairman/President/CEO!Partnerships! Dyadic!has!licensed!its!C1!platform!to!Codexis,!Abengoa!and!BASF!Customers! Global!Financial!Health! ++!(profitable!products)!Catalog!of!Enzymes! ++!Toll!Manufacturing! ++!!

Dyadic!is!known!for!its!unique!expression!platform—the!C1!fungal!microorganism—which!enables!the!expression!and!larege!scale!manufacture!of!enzymes.!!The!company!earns!revenue!by!licensing!this!platform,!as!well!as!in!contract!R&D!and!manufacturing,!and!from!the!sale!of!industrial!enzymes.!

Enzyme!Products:!

Cellulases!

Proteases!

Amylases!

Xylanases!

! ! !!


Endo:glucanases!

Fibrezyme!G5000:!Enzyme!for!refining!pulp!that!reduces!energy!needs!by!improving!pulp!flow.!

Trademarks:!

Fibrezyme®!

Green!Sugars®!

DyadicINSIDE®!

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DyStar'

http://www.dystar.com/!!!

Am!Prime!Park!10:12!!

65479!Raunheim!!

Germany!

Tel:!+49!6142!4072!0!

Fax:!+49!6142!4072!2000!!



2,500!employees!


Small!

Enzyme!categories! Textiles!!!Expression!systems! NA!Capacity/scale! NA.!!In:house!production!not!likely.!Key!People! Harry!Dobrowolski,!Group!CEO!&!President!Partnerships! NA!Customers! Global!Financial!Health! +++!Catalog!of!Enzymes! +!(small!selection)!Toll!Manufacturing! :!!

From!the!company!website:!“DyStar!is!a!leading!provider!of!products!and!services!for!the!textile!and!leather.”!industries.!

Product:!

Sera!Zyme!C:PE!(a!pectinase),!for!bio!scouring!to!remove!waxes!and!oils!from!cotton!fabrics.!

Catalase!

!

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Elanco'

http://www.elanco.us/!!

2500!Innovation!Way!

Greenfield,!IN!46140!!

USA!

Tel:!+1:877:Elanco1!(1:877:352:6261)!


2,500!employees!

Company!type! Subsidiary!of!public!company!Eli!Lilly!Enzyme!sales!absolute!and/or!as!a!percentage!of!company!sales!

Small!

Enzyme!categories! Animal!feed!enzymes.!!!Expression!systems! NA!Capacity/scale! Bulk.!!In:house!production.!Key!People! Jeff!Simmons,!President!Partnerships! NA!Customers! Global!Financial!Health! +++!Catalog!of!Enzymes! +!Toll!Manufacturing! :!!

Elanco!is!the!name!of!the!Eli!Lilly!business!unit!for!animal!health!and!nutrition.!!Elanco!purchased!animal!feed!enzyme!developer!ChemGen!in!early!2012,!and!now!sells!its!enzymes.!

Products:!

Xylanase!

Beta:mannanase!

Beta:glucanase.!

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ElementalEnzymes'

www.elementalenzymes.com!!

1601!South!Providence!Road!

Suite!120!

Columbia,!MO!65211!

USA!

Tel:!+1:913:269:7873!or!+1:314:341:1442!

Email:[email protected][email protected]!!


2!employees!

Company!type! Private!startup!Enzyme!sales!absolute!and/or!as!a!percentage!of!company!sales!

Pending,!but!anticipated!to!be!the!major!revenue!source.!

Enzyme!categories! Soil!and!water!remediation!Expression!systems! Bacterial!Capacity/scale! Small.!!In:house!production.!Key!People! Brian!Thomson,!President!and!CEO!and!Co:Founder;!Katie!Thomson,!Vice:

President!and!Co:Founder!Partnerships! NA!Customers! NA!Financial!Health! NA!Catalog!of!Enzymes! (Pending)!Toll!Manufacturing! :!!

Elemental!Enzymes!is!a!small!startup!created!by!the!husband:and:wife!team!of!Brian!and!Katie!Thomson.!!The!company!has!licensed!enzyme!production!technology!from!University!of!Missouri,!and!the!technology!is!focused!on!enzyme!stabilization.!!!The!professors!at!the!University!responsible!for!the!technology!are!George!Stewart!and!Chung:ho!Lin.!!The!company!was!funded!by!St.!Louis!Arch!Angels!Network!($170,000).!!The!technology!appears!to!be!enzyme!immobilization!onto!biochar.!!!

!

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EMELCA'Bioscience'

www.emelcabio.com!!!

Kapucinessenstraat!30!

B:2000!Antwerpen!

Belgium!

Tel:!+32!!484629800!

Fax:!+32!32262729!



NA!


Small!!

Enzyme!categories! Diagnostic!and!carbohydrate:active!enyzmes.!Expression!systems! NA!Capacity/scale! No!in:house!production.!!Lab:scale!supplier!Key!People! NA!Partnerships! EMELCA!sells!enzymes!from!NZYTech!Customers! NA!Financial!Health! NA!Catalog!of!Enzymes! ++!Toll!Manufacturing! :!!

From!the!website:!“EMELCA!Bioscience!commercialises!reagents!(antibodies,!recombinant!proteins,!peptides,!ELISA!kits,!products!for!use!in!molecular!biology,!primers,!enzymes,!biochemicals)!to!diagnostic!and!research!laboratories.”!!!

Products:!


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!

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Emp'Biotech'GmbH'

http://www.empbiotech.com/!!

Robert:Rössle:Str.!10!

D:13125!Berlin!

Germany!

Tel:!+49!30:9489:2201!

Fax:!+49!30:9489:3201!

E:mail:[email protected]!!


Small!


Small!

Enzyme!categories! Modified!proteases,!immobilized!proteases.!Expression!systems! NA!Capacity/scale! Small.!!In:house!production!Key!People! Derek!Levison,!Uwe!Möller,!both!managing!directors!Partnerships! NA!Customers! NA!Financial!Health! NA!Catalog!of!Enzymes! +!Toll!Manufacturing! :!!

From!the!company!website:!“Founded!in!1993!with!a!strong!focus!in!organic!synthesis,!biomolecular!modification!and!purification,!emp!BIOTECH!provides!quality!reagents!and!services!for!the!life!science!community.!We!manufacture!fine!chemicals,!DNA!synthesis!reagents,!tools!for!molecular!biology,!chromatography!media!and!related!products.!In!addition,!we!provide!contract!organic!synthesis,!protein!and!nucleic!acid!labeling,!peptide!synthesis,!consulting!and!analytical!services.!Furthermore,!we!have!an!ongoing!interest!in!the!fields!of!non:radioactive!detection!systems,!synthetic!organic!and!polymer!chemistries!and!purification!services.!Our!novel!detection!platforms!combine!non:enzymatic!chemiluminescence!signal!amplification!and!fluorescence!enhancement!strategies,!both!supported!by!synthetic!innovations.”!

Products:!

Modified!proteases,!Immobilized!proteases!

! ! !!


Enantis,'s.r.o.'

www.enantis.com!!

Palackeho!trida!1802/129!

612!00!Brno!

Czech!Republic!

Tel:!+420:605!566!804!

Fax:!+420:549!496!302!



1:10!employees.!!Revenues!of!60,000!Euros!in!2010,!and!less!than!that!in!previous!years.!!

Company!type! Private:!Enantis!is!established!in!close!collaboration!with!Loschmidt!Laboratories!at!Masaryk!University!in!Brno,!Czech!Republic.!


Small!

Enzyme!categories! Haloalkane!dehalogenases!for!degradation!of!toxic!sulphur!mustards!Expression!systems! NA!Capacity/scale! Lab!scale.!!In:house!production.!Key!People! Zbynek!Prokop,!CEO!Partnerships! The!company!previously!had!partnerships!with!LentiKats,!BRAIN!AG,!and!

others!but!no!new!partnerships!have!been!announced!since!2009.!Customers! NA!Financial!Health! NA!Catalog!of!Enzymes! +!(about!8!haloalkane!dehalogenases!are!listed)!Toll!Manufacturing! :!!

Enantis!is!a!spin!off!from!Masaryk!University!and!several!members!of!the!university!have!been!or!are!part:time!employees!of!the!company.!!!

From!a!recent!report:!“Enantis!was!established!in!2006!as!the!first!biotechnology!start:up!from!Masaryk!University,!Czech!Republic.!The!company!collaborates!tightly!with!the!Loschmidt!Laboratories!at!Masaryk!University!in!the!development!of!modern!technologies!for!sustainable!growth.!Enantis!provides!consulting!and!R&D!services!in!the!field!of!enzyme!technologies!and!protein!engineering!for!biomedical,!environmental,!agrochemical!and!military:defense!applications.!Enantis!manufactures!own!products!based!on!dehalogenase!enzymes:!whole:cell!and!enzyme!catalysts,!decontamination!kits,!biosensors!and!detection!strips,!optically!pure!chemicals!and!fluorescence!probes.!Our!clients!are!pharmaceutical,!biotechnological!and!military:defense!companies.”!

! ! !!


Products:!

Haloalkane!dehalogenases!

!

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Enartis'(Esseco'Srl)'

http://www.enartis.com/!!

www.essecogroup.com!

Via!S.!Cassiano,!99!!

San!Martino,!28069!Trecate!–!NOVARA!

Italy!

Tel:!+39!0321!790!1!

Fax:!+39!0321!779646!



Large!

Company!type! Network!of!companies!are!part!of!the!Esseco!Group!of!Italy!Enzyme!sales!absolute!and/or!as!a!percentage!of!company!sales!


Enzyme!categories! Winemaking!enzymes.!Expression!systems! Several!Capacity/scale! Multi:ton.!!In:house!production!not!likely.!Key!People! Piero!Nulli,!CEO!Partnerships! NA!Customers! Global!Financial!Health! +++!Catalog!of!Enzymes! +++!(extensive,!detailed,!and!specialized!in!wine!enzymes)!Toll!Manufacturing! :!!

Enartis!is!a!worldwide!network!of!companies!that!distribute!winemaking!goods,!services,!and!light!equipment.!!The!companies!are!all!part!of!the!Esseco!Group,!and!are!called!various!names!in!the!different!regions!they!serve.!!For!example,!in!the!USA,!the!local!branch!of!the!company!is!called!Enartis!Vinquiry.!!All!of!the!various!company!websites!can!be!accessed!centrally!via!www.enartis.com.!!!

Products:!

Pectinases,!Hemicellulases,!Beta:glucanase,!Lysozyme,!Proteases,!Beta:glycosidase!

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Engrain'

http://www.engrain.us/!!

2031!Fort!Riley!Boulevard!

Manhattan,!KS!66502!

USA!

Tel:!+1:785:539:1100!

Fax:!+1:785:539:1102!



5:10!employees!


Significant!revenue!contributor,!as!custom!mixtures!of!enzymes!and!other!materials.!

Enzyme!categories! Milling!and!baking!enzymes.!!!!Expression!systems! Engrain!are!blenders!of!product!and!have!no!enzyme!manufacturing!abilities.!Capacity/scale! Bulk.!!No!in:house!production.!Key!People! Vaughn!Studer,!CEO!Partnerships! Complete!network!of!global!product!support!through!!Research!Products!

Company!and!Specialty!Enzymes!&!Biochemical!Group!Customers! Multiple!countries!Financial!Health! NA!Catalog!of!Enzymes! ++!Toll!Manufacturing! :!!

From!the!website:!“Engrain!offers!the!most!advanced!products!in!the!marketplace.!We!provide!a!full!portfolio!of!performance,!nutrition!and!appearance!products!for!your!milling,!bakery!and!cereal!food!processing!and!pasta!applications.!Our!products!will!help!you!increase!bread!volume,!optimize!pasta!texture!and!enrich!your!baked!goods.!You!will!be!able!to!see!the!difference!we!can!make!in!your!product!line!and!your!bottom!line.”!

Products:!

Though!not!specified,!the!offerings!are!generaelly!blends!of!carbohydrate:degrading!enzymes!and!proteases.!

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ENGroup'

www.engroup.cn!!

F.1,!West!Building!of!IAPPST!

CAAS,!No.2!Yuanmingyuan!West!Road!

Haidian!District,!Beijing,100193!

China!

Tel:!+86!10!6289!0139!

Fax:!+86!10!6283!3152!



25:50!employees!


Nearly!all!revenues!from!enzyme!sales!

Enzyme!categories! Animal!feed.!Expression!systems! Not!revealed,!but!likely!standard!hosts!including!Bacillus,,Aspergillus,,and,

Trichoderma.!Capacity/scale! Bulk.!Annual!production!of!40,000!tons!in:house.!Key!People! NA!Partnerships! EN!Group!includes!the!following!subsidiaries:!

EN!Bio:tech!Limited!Company!Jiangsu!Yinong!Bio:engineering!Co.,!Ltd.!Shuyang!Yinong!Trade!Co.,!Ltd.!Yinong!International!Biotechnology!Private!Ltd.!(in!Singapore)!

Customers! USA,!Russia,!Ukraine,!Thailand,!Vietnam,!South!Korea!and!other!regions.!Financial!Health! NA!Catalog!of!Enzymes! ++!Toll!Manufacturing! :!!

EN!Group!is!a!manufacturer!of!bulk!animal!feed!enzymes.!

Products:!

Phytase,!Xylanase,!Mannanase,!Alpha:galactosidase,!Cellulase!

Beta:glucanase,!Protease,!Amylases!

! ! !!


Enmex'

http://www.enzymes.com.mx/!!

Río!Lerma!No.!228!

Fracc.!Ind.!San!Nicolas!

Tlalnepantla,!Edo.!de!México!54030!

Mexico!

Tel:!+52!(5)!565!5999,!!(5)!565!5992!

Fax:!+52!(5)!390!4826!


NA!


Most!sales!are!enzymes!

Enzyme!categories! Starch!processing,!brewery,!leather,!detergents,!textiles,!fruit!juice,!baking,!dairy,!animal!feed.!

Expression!systems! Non:GMO!microorganism!fermentation.!Capacity/scale! Multi:ton.!In:house!production.!Key!People! NA!Partnerships! CPI,!Gamesa,!Cognis,!Kraft,!Ciba,!etc.!Customers! NA!Financial!Health! NA!Catalog!of!Enzymes! +++!Toll!Manufacturing! :!!

EnMex!started!as!an!importer!of!enzymes,!but!has!since!built!substantial!capacity!in!manufacturing!enzymes!in!house.!!It!distributes!enzymes!and!enzyme!mixtures.!

Products:!

Proteases!

Alpha:amylases!

Glucoamylases!

Invertase!

Dextranase!

! ! !!


Beta:glucanase!

Pectinase!

Cellulase!

Catalase!

Rennet!

Lipase!

Bromelain!

!

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Enzagen,'Ltd'

http://www.enzagen.com!

Newton!Hall,!Town!Street!

Newton!

Cambridge!CB22!7ZE!!

UK!

Tel:!!+44!(0)774!9225986!



1!person!



Enzyme!categories! Biocatalysis!Expression!systems! NA!Capacity/scale! Lab!scale.!!No!in:house!production.!Key!People! Steve!Taylor,!PhD,!Owner.!Partnerships! NA!Customers! NA!Financial!Health! NA!Catalog!of!Enzymes! +!Toll!Manufacturing! :!!

Enzagen!is!a!small!company!that!consults!in!biocatalysis,!offers!procurement!services!and!supplies!biocatalysts,!and!is!a!CRO!for!bioactive!small!molecules!in!drug!discovery.!

Products:!

Kits!of:!

Lipases!

Proteases' !

! ! !!


Enzybel'International'

www.enzybel.com!!

ZAE!de!Ghislenghien!

Rue!des!Gaulois,!7B!

7822!Ghislenghien!

Belgium!

Tel:!+32(0)!68/44!99!61!

Fax:!!+32(0)!68/44!99!62!



NA!



Enzyme!categories! Food,!pet!food,!nutraceuticals,!cosmetics!and!pharmaceuticals!Expression!systems! Extraction!from!plant!tissue!Capacity/scale! Bulk.!!In:house!production.!Key!People! NA!Partnerships! NA!Customers! NA!Financial!Health! NA!Catalog!of!Enzymes! +!Toll!Manufacturing! :!!

From!the!company!website:!“Founded!in!January!2006,!Enzybel!International!had!as!primary!mission!to!answer!the!world:wide!needs!of!plant!proteases!for!food,!pet!food,!nutraceutical,!cosmetic!and!pharmaceutical!industries.”!

Products:!

Papain!

Bromelain!

Ficin!

Actinidin!

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Enzymatic'Deinking'Technologies,'LLC!

http://www.edt:enzymes.com/!!

3975!Steve!Reynolds!Boulevard!!

Norcross,!GA!30093!!

USA!!

Tel:!+1:678:735:3500!

Fax:!+1:678:735:3501!

Email:!ask@edt:enzymes.com!!


51:200!employees!



Enzyme!categories! Pulp!and!paper!Expression!systems! NA!Capacity/scale! Bulk.!!No!in:house!production.!Key!People! NA!Partnerships! NA!Customers! NA!Financial!Health! NA!Catalog!of!Enzymes! ++!Toll!Manufacturing! :!!

Despite!its!name,!Enzymatic!Deinking!Technologies!develops!and!sells!enzymes!for!a!multitude!of!pulp!and!paper!applications!beyond!just!deinking!applications.!!!

Products:!

Cellulases!

Endo:glucanases!

Cellobiohydrolases!

Hemicellulases!

Mannanases!

! ! !!


Xylanases!

Pectinases!

Lipases!

Peroxidases!

Glucose!oxidase!

Esterase!

Protease!

Amylases!

Beta:glucosidases!

Laccases!

!

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Enzymatics'

http://www.enzymatics.com/!!

Suite!407J!!

100!Cummings!Center!!

Beverly,!MA!01915!

USA!

Tel:!+1:888:927:7027!

Tel:!+1:978:927:7027!

Fax:!+1:978:867:5724!



51:200!employees!



Enzyme!categories! Life!science!and!molecular!biology!enzymes,!DNA!and!RNA!modification!enzymes.!

Expression!systems! NA!Capacity/scale! Lab!scale!to!medium!scale.!!In:house!production.!Key!People! Jon!DiVincenzo,!President!and!CEO!Partnerships! NA!Customers! NA!Financial!Health! NA!Catalog!of!Enzymes! +++!(strong!selection!of!enzymes,!about!100)!Toll!Manufacturing! +!!

From!the!company!website:!“Enzymatics!is!an!independent,!ISO!13485:2003!certified!OEM!manufacturer!of!enzymes!that!brings!to!the!marketplace!a!unique,!quality!oriented,!and!customer!focused!approach!to!protein!production.!The!company!was!founded!in!2006!to!specifically!address!the!needs!of!commercial!entities!engaged!in!the!development,!manufacture,!and!distribution!of!platforms!dedicated!to!nucleic!acid!identification.”!

!

!

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Products:!

Extensive!list!of!about!50!enzymes!that!includes:!Ligases,!Restriction!enzymes,!Polymerases,!Phosphatases,!Reverse!transcriptases! !

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Enzyme'Development'Corporation'

www.EnzymeDevelopment.com!!

505!8th!Ave,!Suite!1500!!

New!York,!NY!!10018!!

USA!

Tel:!+1:212:736:1580!

Fax:!+1:212:279:0056!



About!10!employees,!about!$20!million!in!revenues!


100%!of!sales!are!enzymes!or!assays!for!the!enzymes.!

Enzyme!categories! Animal!feed,!baking,!brewing!and!winemaking,!dairy,!juice,!textiles.!Expression!systems! Aspergillus,,Rhizopus,,Candida,,Mucor,,Bacillus,!and!Trichoderma!expression,!

and!isolation!of!enzymes!from!plants!and!animal!tissue.!Capacity/scale! Bulk.!!Some!products!made!in:house.!Key!People! Peter!Moodie,!President!Partnerships! Partnership!with!!Fytozimus!Biotech!to!distribute!Fytozimus’!Aspartic!Acid!

Protease!in!the!USA!Customers! NA!Financial!Health! ++!(estimated)!Catalog!of!Enzymes! ++!(strong!selection)!Contract!Manufacturing! :!!

From!the!company!website:!“Enzyme!Development!Corporation!manufactures!and!supplies!enzyme!products.!Its!enzyme!products!include!Its!products!are!used!in!various!applications,!including!animal!feed,!baking,!brewing,!dairy,!ethanol,!flavor,!juice,!nutraceutical,!petfood,!tenderizer,!textile,!wine,!and!other!applications.!The!company!was!founded!in!1953!and!is!based!in!New!York,!New!York.”!

Products:!

Catalase!

Cellulases!

Lipases!

! ! !!


Esterases!

Pectinases!

Proteases!

Xylanases!

Tannase!

Urease!

Lysozyme!

Bromelain!

Papain!! !

! ! !!


!

Enzyme'Solutions'

http://www.enzymesolutions.com.au/!!

26!Research!Drive!

Croydon!South,!VIC,!3136!

Australia!

Tel:!(03)!9761!7999!

Fax:!(03)!9761!7899!



10:20!employees!


Most!sales!are!enzymes.!

Enzyme!categories! Enzymes!for!Baking,!Brewing,!Cleaning,!Dairy,!Ethanol,!Fruit!Juice!and!Olive!Oil!production,!Grain!Processing,!Paper,!Protein!Processing,!!Specialty!Enzymes,!Therapeutic,!Textiles,!Waste!Treatment!&!Wine.!

Expression!systems! Manufacturing!not!done!in!house!Capacity/scale! Bulk.!!No!in:house!production.!Key!People! Geoff!Bearzatto,!Managing!Director!(CEO)!and!Co:Founder!Partnerships! DuPont!and!Godo!Shushei!are!the!suppliers!of!most!of!the!enzymes!that!

Enzyme!Solutions!distributes.!Customers! Australian!market!primary,!but!exports!to!other!countries!as!well!Financial!Health! ++!(estimated!to!be!profitable!and!stable)!Catalog!of!Enzymes! +++!(Wide!variety!from!reputable!suppliers)!Toll!Manufacturing! :!!

From!the!company!website:!“Established!in!Melbourne!over!15!years!ago!:!the!enzymes!originate!from!DuPont!Industrial!Biosciences.,!Danisco!Australia!Pty!Ltd,!and!Godo!Shusei!Co!Ltd!amongst!other!key!strategic!partners.!!Additionally,!we!formulate!and!produce!many!of!our!own!enzyme!based!products!using!the!experience!we!have!gained!over!many!years.!!Close!collaboration!with!our!customers!can!achieve!unique!products!and!processes.!!Examples!of!locally!produced!products!are!Optivin®,!Oleo!Flo®,!Fermassist®,!Acidolact®,!ProtiBond!TG®,!Solvabrew!and!OptiCarb.”!

!

! ! !!


Products:!

Amylases!

Proteases!

Lipases!

Xylanases!

Papain!

Beta:glucanase!

Glucoamylase!

Cellulases!

Mannanase!

Lactase!

Pectinases!

Bromelain!

Hemicellulases!

Catalase!

Glucose!oxidase!

Lysozyme!

Beta:glycosidase!

! !

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!

Enzyme'Solutions'(USA)'

www.enzymesolutions.com!!

2105!Forrest!Park!Drive.!

Garrett,!IN!46738!

USA!

Tel:!+1:260:497:0851!or!+1:800:523:1323!

Fax:!+1:260:497:0512!


Small!


Major!revenue!stream!as!part!of!formulated!products.!

Enzyme!categories! Detergents,!cleaning!applications.!Expression!systems! NA!Capacity/scale! Bulk.!!In:house!production.!Key!People! Tim!Beck,!CEO!Partnerships! NA!Customers! NA!Financial!Health! NA!Catalog!of!Enzymes! +!(formulated!into!cleaning!products)!Toll!Manufacturing! ++!!

Enzyme!Solutions!provides!cleaning!agents,!many!of!which!contain!enzymes.!

From!the!company!website:!“Enzyme!Solutions!is!a!U.S.!based!manufacturer!of!enzymes!and!enzyme!products.!All!manufacturing,!testing,!formulation!and!bottling!are!conducted!in!its!manufacturing!plant,!located!in!Fort!Wayne,!Indiana.”!

Products:!

Proteases!

Lipases!

Amylases! !

! ! !!


Enzyme'Supplies'Limited'

http://www.enzymesupplies.com/!!

John!Eccles!House!

Robert!Robinson!Avenue!

The!Oxford!Science!Park!

Oxford!OX4!4GP!

UK!

Tel:!+44!(01865)!338!095!

Fax:!+44!(01865)!338!100!


Year!Founded! 2010!or!ealier!Size!($!or!employee!count!or!both)!

Small!



Enzyme!categories! Enzymes!for!Alcohol,Biofuels,!Biomass,!Brewing,!Dairy,!Detergents,!Food!functionality,!Fruit!&!vegetable,!Pulp!&!paper,!Starch.!!Additional!enzymes!available!for!specialty!applications,!mostly!in!diagnostics.!

Expression!systems! None!Capacity/scale! Bulk.!!No!in:house!production.!Key!People! Paul!Richards,!Managing!Director!(CEO)!Partnerships! Suppliers!are!not!indicated,!but!Enzyme!Supplies!appears!to!be!a!distributor!

of!enzymes!with!no!manufacturing!capabilities.!Customers! NA!Financial!Health! NA!Catalog!of!Enzymes! ++!!Toll!Manufacturing! :!!

From!the!company!website:!“Our!mission!is!simple;!to!provide!a!comprehensive!range!of!enzymatic!&!biological!solutions!for!our!customers!to!help!them!maximise!the!potential!of!their!businesses!&!products.”!

Products:!

Amylases!

! ! !!


Glucoamylase!

Cellulases!

Proteases!

Xylanases!

Phytases!

Papain!

Lactase!

Catalase!

Lipases!

Pectinases!

Alpha!chymotrypsin!!

Acetyl!Cholinesterase!(AChE)!!

Acid!phosphatase!!

Acylase!!

Alkaline!phosphatise!!

Alcohol!dehydrogenase!!

Alpha:glucosidase!!

Beta:glucosidase!!

Bromelain!

Butyl!Cholinesterase!!

Carbonic!anhydrase!!

Chymotrypsin!!

Chymotrypsinogen!!

Deoxyrobonuclease!(DNase)!!

Elastase!!

! ! !!


Glutamate!dehydrogenase!!

Hyaluronidase!!

L:Arginase!!

Lactoperoxidase!!

Malate!dehydrogenase!!!

Mutarotase!!

Peroxidase!(horseradish)!!

Pepsin!!

Phospholipase!!

Phosphorylase!!

Ribonuclease!!

Sulphatase!!

Trypsin!!

Transaminase!!

Urease!!

Uricase!!!

!

! !

! ! !!


EnzymeKing'Biotechnology'Co.'Ltd.'

www.enzymeking.com!!

Hi:Tech!!Economic!Park,!YUanbaoshan!Dist.!

Chifeng!City,!Inner!Mongolia,!China!

China!

Tel:!+86:10:853:25499!

Fax:!+86:10:853:25499!



Over!100!employees.!


All!revenues!from!enzyme!sales.!

Enzyme!categories! Pharmaceutical,!food,!cosmetics,!research.!Expression!systems! Extraction!from!animal!tissue.!Capacity/scale! Bulk.!In:house!manufacture.!Key!People! Henry!Chong,!Vice!President!Partnerships! NA!Customers! NA!Financial!Health! NA!Catalog!of!Enzymes! +!Toll!Manufacturing! :!!

From!the!website:!“Enzymeking!Biotechnology!Company!Limited.!specializes!in!manufacture,!distribution,!and!supply!pharmaceutical!raw!materials!for!application!in!the!fields!of!pharmaceutical,!scientific!research,!foods!&!cosmetics.”!

Products:!

Trypsin!

Chymotrypsin!

Kallidogenase!(kallikrein;!catalyzes!conversion!of!kallidin!from!kinnogen;!claimed!to!reduce!blood!pressure!and!sold!as!a!pharmaceutical!in!China,!but!not!in!USA.)!

Ribonuclease,!Deoxyribonuclease!

! ! !!


Enzymes'Naveen'

9,!Spencer!House!

Karnataka!82,!Coles!Road!

Frazer!Town,!Bangalore!560005!

India!

Tel:!+919342190781!

Tel:!+91:80:25309841!

Fax:!+91:80:25587055!


5:10!employees!


Important!minority!revenue!source!

Enzyme!categories! Food,!textiles,!effluent!treatment.!Expression!systems! NA!Capacity/scale! Bulk.!!No!in:house!production!Key!People! Naveen!Jaidka!Partnerships! NA!Customers! NA!Financial!Health! NA!Catalog!of!Enzymes! +!Toll!Manufacturing! NA!!

Enzymes!Naveen!is!a!re:seller!of!enzymes!and!other!products!related!to!food!processing,!textiles,!effluent!treatment,!and!other!applications.!!

Products:!

Laccase!

Cellulase!

Amylase,!Glucoamylase!

Xylanase!

Protease,!Lipase! !

! ! !!


EnzymeWorks'Inc'

www.enzymeworking.com!!

603!Gangcheng!Rd.!

Zhang!Jiagang!

Jiangsu!215600!

China!

Tel:!+86!512!888!38789!


Year!Founded! About!2011!Size!($!or!employee!count!or!both)!

>100!


Mostly!focused!on!contract!R+D!and!manufacture.!

Enzyme!categories! Biocatalysis!!!Expression!systems! NA!Capacity/scale! Multi:ton!scale.!!In:house!production.!Key!People! Junhua!(Alex)!Tao,!Founder!Partnerships! NA!Customers! NA!Financial!Health! NA!Catalog!of!Enzymes! ++!Toll!Manufacturing! ++!(large!scale,!short!operational!history)!!

EnzymeWorks!offers!contract!research!and!manufacturing!for!biocatalysts,!and!also!has!a!small!catalog!of!enzymes.!!!EnzymeWorks!targets!pharma!and!generics!companies,!fine!chemicals!producers,!flavor!and!fragrance!companies,!and!agriculture.!!The!company!also!applies!its!enzymes!and!traditional!chemical!strengths!to!manufacturing!of!APIs!and!intermediates!and!to!the!production!of!secondary!metabolites.!!EnzymeWorks’!website!explains!that!it!has!research!capabilities!in!protein!engineering,!enzyme!purification,!enzyme!formulation,!enzyme!immobilization,!fermentation!optimization,!biotransformation!screening,!process!development,!drug!metabolite!synthesis,!and!process!optimization.!

Products:!

Acyltransferase!

! ! !!


Aldolase!

Amine!oxidase!

Amino!acid!dehydrogenase!

Cytochrome!P450!monooxygenases!

Dehydrogenases!for!cofactor!regeneration!

Ketoreductases!

Nitrilases!

Amidases!

Enolate!reductases!

Glycosidases!

Nitrile!hydratase!

Nitro!reductase!

Oxynitrilase!

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'

Enzymicals'AG'

www.enzymicals.com!!!

Walther:Rathenau:Strasse!49a!

17489!Greifswald!

Germany!

Tel:!+49:3834:51547:0!

Fax:!+49:3834:51547:3!



12!employees!


Sales!of!enzymes!and!kits!and!contract!research!are!the!main!revenue!sources.!

Enzyme!categories! Biocatalysis!!Expression!systems! E.,coli,Capacity/scale! Small!quantities!offered,!bulk!amounts!by!request!Key!People! Ulf!Menyes,!CEO.!Partnerships! BRAIN!AG!and!Braun!Beteilgungs!GmbH!have!minority!ownerships!interests!

in!the!company.!!Along!with!a!third!partner,!Herbrand,!these!entities!enable!Enzymicals!to!access!a!broad!range!of!technologies!from!screening!metagenomic!DNA!libraries!to!biocatalysis!process!development.!

Customers! NA!Financial!Health! NA!Catalog!of!Enzymes! ++!Toll!Manufacturing! +!!

Enzymicals!is!primarily!a!service!provider!offering!screening!of!a!selection!of!existing!enzymes,!synthetic!expertise!for!using!enzymes!as!biocatalysts,!and!enzyme!customization!using!directed!evolution!and!semi:rational!mutagenesis.!!The!company!also!offers!a!catalog!of!enzymes!and!enzyme!kits.!!!

Products:!

8!(R):selective!transaminases!(licensed!from!Lonza,!June!2011)!

6!bacterial!Baeyer:Villiger!Monooxygenases!

! ! !!


6!isozymes!of!pig!liver!esterase!(exclusive!license!from!Evonik,!October!2010)!

1!amino!acylase!

10!bacterial!esterases!

These!enzymes!are!available!individually!and!in!kits.!

!

!

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Enzymology'Research'Center,'Inc'

http://www.ercenzymes.com/!!

206!West!Street!North!

Miltona,!MN!56354!

USA!

Tel:!+1:218:943:9127!

Fax:!+1:218:943:9128!

Tel:!+1:888:661:1100!

Fax:!+1:888:677:1100!

Emails:[email protected];[email protected]!!


about!11:50!employees!


Enzymes!sales!are!nearly!all!revenues.!

Enzyme!categories! Neutraceuticals!Expression!systems! NA!Capacity/scale! 10,000!sq.!ft.!manufacturing!facility!Key!People! Troy!Aupperle,!Founder!and!CEO!Partnerships! NA!Customers! NA!Financial!Health! NA!Catalog!of!Enzymes! +!Contract!Manufacturing! ++!(GMP!compliant)!!

From!the!company!website:!“ERC!is!a!leading!contract!manufacturer!that!specializes!in!enzymes!and!enzyme:based!products.!Our!facilities!operate!under!strict!Good!Manufacturing!Practices!(GMP’s)(2009)”!

Products:!

Chymotrypsin,!Pancreatin,!Pancrelipase,!Pepsin,!Trypsin!

!

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Enzyvia'LLC'

www.enzyvia.com!!

214!South!Main!Street!

Sheridan,!IN!46069!!

USA!

Tel:!+1:800.497.5580!

Fax:!+1:317.758.2697!


501:1000!employees!(parent!company)!

Company!type! Private,!subsidiary!of!JBS!United.!Enzyme!sales!absolute!and/or!as!a!percentage!of!company!sales!


Enzyme!categories! Animal!feed.!Expression!systems! Two!undisclosed!fungal!strains!Capacity/scale! Bulk.!!In:house!manufacturing.!Key!People! NA!Partnerships! NA!Customers! NA!Financial!Health! NA!Catalog!of!Enzymes! +!Toll!Manufacturing! :!!

From!a!press!release:!“Enzyvia!LLC!is!a!global!company!based!in!Sheridan,!IN!that!researches,!develops!and!commercialized!value!added!feed!additives!for!animal!production!and!improvement.!Enzyvia!LLC!is!a!wholly!owned!subsidiary!of!JBS!United!which!is!a!leading!global!agricultural!products!company!based!in!Sheridan,!Indiana.!Since!its!founding!in!1956,!JBS!United!has!been!dedicated!to!providing!research:based!solutions!to!enhance!animal!nutrition!and!livestock!production!profitability.!The!company!provides!various!products!and!services!to!swine,!dairy!cattle,!poultry!and!other!animal!producers!worldwide.”!

Products:!

Enzyme!mixture!formulation!consisting!of!carbohydrate!hydrolases.!

!

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EpiCentre'Biotechnologies'

http://www.epibio.com/!!

5602!Research!Park!Blvd.,!Suite!200!

Madison,!WI!53719!!

USA!

Tel:!+1:800:284:8474!!

Tel:!+1:608:258:3080!!

Fax:!+1:608:258:3088!!



51:200!employees!

Company!type! Private,!owned!by!the!public!company!Illumina!Enzyme!sales!absolute!and/or!as!a!percentage!of!company!sales!

Significant!portion!of!revenues!derived!from!enzymes.!

Enzyme!categories! Life!science!enzymes,!molecular!biology.!Expression!systems! E.,coli,!likely!others!Capacity/scale! Bulk.!!In:house!production!Key!People! NA!Partnerships! NA!Customers! NA!Financial!Health! +++!Catalog!of!Enzymes! ++!Toll!Manufacturing! +++!!

From!the!company!website:!“Epicentre®!Biotechnologies,!founded!in!1987,!uses!its!expertise!in!enzyme!manufacturing!to!produce!innovative!kits!for!life!science!research.!The!kits!and!reagents!manufactured!by!Epicentre!contribute!to!breakthrough!studies!in!genomics!and!transcriptomics.!Products!are!available!for!DNA!and!RNA!sequencing,!gene!expression!analysis,!DNA!and!RNA!purification,!PCR!and!RT:PCR,!cloning,!in!vitro!transcription,!and!microbial!genomics.”!

Products:!


DNA!and!RNA!Polymerases!

! ! !!


Ligases!

Deadenylase!

Glucosyltransferase!

Lysozyme!

Glycosylases!

Phosphatases!

Kinases!

!

!

!

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Epygen'Labs'FZ'LLC'

www.epygen.com!!

PBU!WH!Block!D21:D22!

DUBIOTECH!Park!

Umm!Suqeim!Road!

PO!Box!485018!Dubai!

United!Arab!Emirates!

Tel:!+971!4!457!2850!

Fax:!+971!4!457!2961!



11:50!employees!


Enzymes!are!a!significant!source!of!revenues,!though!the!company!seems!to!be!emphasizing!therapeutic!protein!capabilities!going!forward.!

Enzyme!categories! Oil!field!applications,!biomass!conversion,!pulp!and!paper,!textiles!and!detergnets,!food!and!feed,!leather.!!

Expression!systems! Bacillus,subtilis,,Trichoderma,!others.!Capacity/scale! Bulk!Key!People! Debayan!Ghosh,!Co:Founder!and!President;!Ariyarathenam!Manickam,!Co:

Founder!Partnerships! Partnered!with!Saudi!Aramco!to!test!its!oil!field!enzymes.!Customers! Global!Financial!Health! NA!Catalog!of!Enzymes! ++!Toll!Manufacturing! :!!

Epygen!is!a!producer!and!supplier!of!industrial!enzymes.!!The!company!has!research!and/or!manufacturing!capabilities!in!the!USA,!United!Arab!Emirates,!and!India.!!A!new!plant!in!India!is!designed!for!purposes!including!therapeutic!protein!production,!and!Epygen!has!recently!been!emphasizing!the!potential!of!enzymes!and!other!proteins!for!cardiovascular!health.!!!

Products:!

Cellulases!

! ! !!


Mannase!

Alpha:amylases!

Proteases!

Hemicellulases!

Phytase!

Xylanase!

Lipases!

Pectinase!

Tannase!

Glutaminases!

Catalase!

Laccase!

! !

! ! !!


ERA'Biotech'

http://www.erabiotech.com/!!

Calle!Baldiri!i!Reixach,!nº!15!:!21!!

08028!Barcelona!

Spain!

Tel:!+34!93!403!47!73!!

Fax:!+34!93!403!47!72!!



32!employees!


NA!

Enzyme!categories! NA!Expression!systems! Custom!Zera!peptide!platform!for!high:protein!expression.!!Works!in!insect!

and!mammalian!cells!as!well!as!fungal!hosts.!Capacity/scale! Small!Key!People! Miriam!Bastida,!Managing!Director!(CEO)!Partnerships! NA!Customers! NA!Financial!Health! ++!(funded!by!venture!groups!and!government!grants)!Catalog!of!Enzymes! NA!Toll!Manufacturing! ++!(offers!a!custom!platform!for!high!protein!expression)!!

ERA!Biotech!is!based!around!a!technology!to!highly!express!proteins!attached!to!a!linker!that!can!then!be!easily!purified.!!!

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Erbslöh'Geisenheim'AG'

http://www.erbsloeh.com/!!

Erbslöhstraße!1!

65366!Geisenheim!

Germany!

Tel:!+49!6722!708:0!

Fax:!+49!6722!6098!


Year!Founded! Over!100!years!old!Size!($!or!employee!count!or!both)!

130!employees!


Relatively!small!

Enzyme!categories! Enzymes!for!alcoholic!and!non:alcoholic!beverage!production.!Expression!systems! Likely!Aspergillus!and!Bacillus!Capacity/scale! Bulk.!!In:house!production!likely.!Key!People! Managing!Directors:!Dietmar!Hemmert,!!Jörg!Möller!Partnerships! La!Littorale!in!France!is!a!wholly:owned!subsidiary.!!Sells!through!Greatown!

International!Co.,!LTD!in!China,!!Customers! Sells!globally.!Financial!Health! +++!(estimated)!Catalog!of!Enzymes! ++!Toll!Manufacturing! :!!

Erbslöh!supplies!enzymes,!yeasts,!and!other!additives!and!fermentation!enhancers!to!producers!of!juices!and!alcoholic!beverages!including!wine,!beer,!and!spirits.!!

Products:!

Pectinases!

Alpha:amylases!

Beta:glucanases!

Xylanases!

Glucoamylase' !

! ! !!


Eucodis'Bioscience'GmbH'

http://www.eucodis.com/!!

Campus!Vienna!Biocenter!II!

Viehmarktgasse!2!a/!2.!OG!

1030!Vienna!

Austria!

Tel:!+!43!1!8900804!

Fax:!+43!1!8900804!ext.!11!



11:50!employees!


As!of!early!2013,!enzyme!and!protein!engineering!services!make!up!about!65%!of!Eucodis’!revenues.!

Enzyme!categories! Biocatalysis!Expression!systems! E.,coli,,Bacillus,subtilis,,Pichia,pastoris,Capacity/scale! Eucodis!can!produce!proteins!on!up!to!the!kg!scale!using!fermentations!of!up!

to!1000!L!Key!People! Karl!Hübler,!CEO;!Jan!Modregger,!Head!of!R!&!D!Partnerships! Eucodis!and!Evocatal!co:marketed!products!in!the!past,!but!this!agreement!is!

thought!to!no!longer!be!active.!!Customers! Eucodis!lists!the!following!companies!as!customers:!Dr.!Reddy’s,!Genencor,!

Genzyme,!GSK,!Henkel,!Lohmann!Animal!Health,!Roche,!Sandoz,!and!Sigma:Aldrich.!

Financial!Health! NA!Catalog!of!Enzymes! +!Toll!Manufacturing! ++!!

Eucodis!was!originally!founded!to!apply!proprietary!in!vivo!recombination!and!somatic!hypermutation!methods!to!both!the!chemical!biotechnology!and!the!pharmaceuticals!markets.!!In!2007,!the!company!dropped!the!focus!on!pharmaceuticals.!!However,!the!company!recently!undertook!a!major!effort!on!pharmaceutical!antibody!drug!conjugates,!called!CTAT!(C:Terminal!amidotransferase).!!Since!2009,!the!company!has!been!offering!a!catalog!of!enzymes!for!purchase,!and!enzyme!kits.!!The!company!has!a!focus!on!lipases,!but!also!offers!other!enzymes.!!!Eucodis’!first!product!was!LacBusterTM,!which!is!a!

! ! !!


brand!of!beta:lactamases!first!offered!in!2010.!!The!company!offers!custom!manufacturing,!and!is!experienced!in!fermentation!development,!downstream!processing,!and!protein!characterization.!

Products:!

Lipases!(more!than!20!proprietary!enzymes)!

Lac:Buster!(broad:range!beta:lactamase)!

Kit!of!more!than!20!lipases!

Phospholipases!

Nitrile!hydratase!



Hydroxynitrilases!

Transaminases!

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evocatal'Gmbh'

http://www.evocatal.com/!!

Alfred:Nobel:Strasse!10!

40789!Monheim!am!Rhein!

Germany!

Tel:!+49!(0)2173:40994:0!

Fax:!+49!(0)2173:40994:40!



21!employees!


Major!revenues!are!probably!collaborative!research;!enzymes!likely!make!up!a!minority!portion!of!revenues.!

Enzyme!categories! Biocatalysis!Expression!systems! In:house!tailored!strains!of!E.,coli!and!Bacillus,subtilis!Capacity/scale! Though!it!has!fermentation!expertise,!the!company!appears!to!have!limited!

scale!up!abilities!in!house,!and!it!works!with!partners!to!produce!larger!amounts!of!enzyme.!

Key!People! Thorsten!Eggert,!CEO!and!Founder;!Michael!Puls,!Business!Development;!Thomas!Daussmann,!Adivsor!

Partnerships! Evocatal!has!established!partnerships!with!a!number!of!high:profile!companies!including!Henke,!Sartorius,!Lanxess,!Symrise,!Digital!Specialty!Chemicals,!Rohner!Chem,!Eucodis!Bioscience,!m2p!labs,!and!artes.!!Eucodis!and!Evocatal!announced!a!co:marketing!agreement,!but!it!is!thought!to!noloonger!bne!active.!

Customers! NA!Financial!Health! NA!Catalog!of!Enzymes! ++!Toll!Manufacturing! NA!!

Evocatal!was!spun:off!from!the!Institute!of!Molecular!Enzyme!Technology,!Heinrich:Heine:University!of!Düsseldorf.!!The!company!sells!both!products!and!services.!!The!products!include!off!the!shelf!biocatalysts,!chiral!compounds,!a!set!of!73!chaperone!proteins!from!different!organisms,!and!a!family!of!fluorescent!proteins!called!everglow!that!function!in!both!aerobically!and!anaerobically!grown!cells.!!The!services!include!enzyme!identification!in!the!company’s!metagenomic!DNA!libraries!of!unculturable!

! ! !!


organisms!recombinantly!expressed,!and!directed!evolution!to!optimize!the!enzymes!to!meet!process!demands.!!!

Evocatal!moved!in!late!2o013!to!a!new!site!in!Monheim!am!Rhein,!gainng!larger!space!and!room!for!further!expansion.!The!move!came!about!in!conjunction!with!a!EUR!3.5!million!equity!investment!completed!in!June!2013.!Cologne:based!chemical!company!Lanxess!participated!in!this!financing.!

Products:!

TPP:enzymes!


Ketoreductases!

Transaminases!

Lipases!

Hydroxynitrile!lyases!

Cofactor!regeneration!enzymes!!

Kit!6!transaminases!

Kit!of!19!lipases!

Kit!of!12!alcohol!dehydrogenases!and!ketoreductases!

Kit!of!7!TPP!enzymes!

!

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Fenkim'

http://www.fenkim.com/!!

BARBAROS!BULVARI!YILDIZ!APT.!NO!69/3!

34353!BESIKTAS!–!ISTANBUL!!

Turkey!

Tel:!+90!212!227!50!47!

Fax:!+90!212!227!52!64!



5:10!employees!


Major!part!of!revenues!

Enzyme!categories! Textiles!!!Expression!systems! NA!Capacity/scale! Bulk.!!No!in:house!production.!Key!People! NA!Partnerships! NA!Customers! NA!Financial!Health! NA!Catalog!of!Enzymes! +!Toll!Manufacturing! :!!

From!the!company!website:!“Fenkim!Kimya!Sanayi!Ve!Ticaret!limited!sirketi!started!its!business!in!2002!as!textile!enzyme!distributor.!Currently,!Fenkim!deals!with!trade!of!textile!enzymes!and!all!kinds!of!textile!products!(i.!E.!Towel,!lingerie)!worldwide.!Our!mission!is!to!share!our!experience!in!textile!industry!with!our!precious!customers.”!

Products:!

Alpha:amylases!

Cellulase!

Lipase,!Protease!

Mannase' !

! ! !!


Fermenta'Biotech'Ltd'

http://www.fermentabiotech.com/!!

'dil'!complex,!Ghodbunder!Road!

Majiwada,Thane!(West)!!

400!610,!Maharashtra!

India!

Tel:!+91!22!6798!0888!!

Fax:!+91!22!6798!0999!



201:500!employees!



Enzyme!categories! Penicillin!G!Amidase,!Penicillin!G!Acylase,!Cal!B!Lipase,!Candida,Antarctica!Lipase!B,!Enzyme!Immobilization!

Expression!systems! NA!Capacity/scale! Bulk!Key!People! Prashant!Nagre,!Chief!Executive!Officer!Partnerships! Fermenta!supplies!its!immobilization!material!to!Chiral!Vision!Customers! Global!Financial!Health! ++!(steadily!growing!profits)!Catalog!of!Enzymes! +!Toll!Manufacturing! +!(immobilization!platform)!!

Fermenta!is!a!major!producer!of!vitamin!D3!and!of!enzymes!for!the!synthesis!of!penicillin!and!cephalosporin!antibiotics.!The!company!also!produces!two!lipases,!beads!for!enzyme!immobilization,!and!immobilized!enzymes.!!In!addition,!the!company!has!a!division!called!environmental!solutions!that!provides!information,!services,!and!products!for!lake!remediation,!waste!water,!and!solid!waste.!!!

Products:!Immobilized!and!soluble!versions!of!

Penicillin!G!Amidase!(Penicillin!G!Acylase)!

Cal!B!Lipase!(Candida,antarctica!Lipase!B)!

! ! !!


Fermentia'

http://www.fermentia.eu/!!

Berlini!utca!47:49!

H:1045!Budapest!

Hungary!

Tel:!+36:30:3502847!

Fax:!+36:1:3696024!



12!employees!


Very!small,!mostly!a!service!provider.!

Enzyme!categories! Immobilized!lipases!Expression!systems! GMO!and!non:GMO!Capacity/scale! Up!to!1000!L!fermenations!Key!People! Balázs!Erdélyi!,!Operating!manager!(CEO)!and!Founder!Partnerships! Several!undisclosed,!SynBiocat!Ltd.!Customers! Axis:Shield!Ltd,!BactoFil,!others!undisclosed.!Financial!Health! Not!indicated,!but!the!company!has!been!growing.!Catalog!of!Enzymes! +!(a!small!selection!of!immobilized!lipases!is!offered!in!partnership!with!

SynBiocat!Ltd.)!Toll!Manufacturing! ++!(CMO)!!

Fermentia!is!a!custom!manufacturing!organization!in!Hungary!that!specializes!broadly!in!fermentation.!!It!produces!enzymes,!proteins,!DNA,!small!molecules,!and!other!fermentation!products.!!It!has!a!partnership!with!a!small!startup!called!SynBiocat!to!manufacture!immobilized!lipases,!and!it!lists!these!lipases!as!products!on!its!website.!!These!lipases!are!the!only!products!that!Fermentia!offers,!and!its!business!is!almost!exclusively!contract!manufacturing.!

Products:!

Immobilzed!lipases!(6,!available!individually!or!as!a!kit)!

!

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Fytozimus'Biotech'Inc.'

http://www.fytozimus.com/!!

Edmonton,!Alberta! T5J!2G1!

Canada!

Tel:!+1:780:476:9099!

Tel:!+1:866:476:9099!

Fax:!+1:780:475:6757!



10:20!employees!


Most!to!all!sales!are!enzymes!

Enzyme!categories! Dairy!enzymes,!proteases!plant!sources!for!cheese!making!without!animal:derived!enzymes.!

Expression!systems! Extraction!from!plant!material.!Capacity/scale! Bulk.!!In:house!production.!Key!People! Maria!Salomé!Pais,!Founder!&!CEO!Partnerships! Enzyme!Development!Corp!Customers! Through!partners!Enzyme!Development!Corp!sells!its!protease!enzyme!in!the!

USA!Financial!Health! NA!Catalog!of!Enzymes! +!Toll!Manufacturing! :!!

From!the!company!website:!“Fytozimus!Biotech!Inc.,!founded!by!Dr.!Maria!Salomé!Pais,!was!formed!to!meet!dairy!manufacturers'!needs!for!a!more!natural,!flexible!and!environmentally!conscious!approach!to!the!creation!of!their!products.!!With!its!corporated!headquarters!located!in!the!economically!strong!region!of!Edmonton,!Alberta,!Canada!and!its!research!offices!in!historic!Lisbon,!Portugal,!Fytozimus!is!well!positioned!to!expand!globally.!!Fytozimus'!plant:based!products!offer!the!potential!to!create!cheeses!with!new!and!exotic!textures!and!aromas,!in!a!highly!competitive!and!demanding!market.”!

Products:!

Proteases!

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Galilaeus'Oy'

http://www.galilaeus.fi/!!

Rakentajantie!26!

20780!Kaarina!

Finland!

Tel:!+358:20!7218!460!



51:200!


Only!through!contract!manufacturing.!

Enzyme!categories! NA!Expression!systems! Primarily!E.,coli,!also!experienced!with!Streptomyces,!fungi!and!yeasts.!Capacity/scale! Fermentation!capacity!from!2!L!up!to!15,000!L.!!Production!runs!take!place!at!

the!company’s!plant!in!Poland.!Key!People! NA!Partnerships! NA!Customers! NA!Financial!Health! NA!Catalog!of!Enzymes! :!Toll!Manufacturing! +++!!

From!the!company!website:!“Galilaeus!is!specialized!in!fermentative!manufacturing!with!microbes!in!three!business!lines:!APIs,!Biocatalysts!and!Nutraceuticals.!!Galilaeus!Oy!is!one!of!the!leading!contract!manufacturers!in!the!biotech!field,!and!we!have!the!largest!fermenter!unit!in!Europe.!Galilaeus!offers!its!clients!flexible,!varied!service!packages!together!with!co:operation!producing!added!value!to!our!customers.”!!!

!

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Genkim'

www.genkim.com.tr!!

BURSA!Organize!Sanayi!Bölgesi!Lacivert!Cadde!2!

Sokak!No:!Nilüfer!

BURSA!

Turkey!

Tel:!+90!224!241!7780!

Fax:!+90!224!241!7784!



Small!


Small!

Enzyme!categories! Textile!enzymes!Expression!systems! NA!Capacity/scale! Bulk,!likely!no!in:house!production!Key!People! Ali!Suavi!Kuter,!General!Manager!Partnerships! NA!Customers! NA!Financial!Health! NA!Catalog!of!Enzymes! +!Toll!Manufacturing! :!!

Genkim!is!a!textile!chemical!supplier.!

Products:!

Catalase!

Cellulase!

Alpha:amylase!

!

!

! ! !!


GenScript'USA,'Inc.'

http://www.genscript.com/!!

860!Centennial!Ave.!

Piscataway,!NJ!08854!

USA!

Tel:!+1:877:436:7274!

Tel:!+1:732:885:9188!

Fax:!+1:732:210:0262,!+1:732:885:5878!

Email:[email protected]!! !!


1,200!employees!


Small!

Enzyme!categories! Life!science!enzymes.!Expression!systems! Multiple!Capacity/scale! Up!to!300!g!scale.!!In:house.!Key!People! NA!Partnerships! NA!Customers! NA!Financial!Health! NA!Catalog!of!Enzymes! +!Toll!Manufacturing! +!!

Founded!in!2002,!GenScript!is!an!international!provider!of!biology!products!and!services.!!These!are!grouped!into!four!main!areas:!Bio:Reagent,!Bio:Assay,!Lead!Optimization,!and!Antibody!Drug!Development.!!The!company!offers!custom!protein!expression!and!purification.!!

Products:!

Proteinase!K!

Enterokinase!


Streptokinase,!Proteases!

! ! !!


GNC'Bioferm'Inc'

www.gncbioferm.ca!!

1221!Wilder!Road!

Cobble!Hill,!B.C.!V0R!1L0!

Canada!!

Tel:!+1:250:743:7850!!

Fax:!+1:250:743:7860!!



Small!to!medium!


Most!to!all!

Enzyme!categories! Animal!feed!enzymes!Expression!systems! Aspergillus!(non:GMO)!Capacity/scale! Multi:ton.!!In:house!manufacture.!Key!People! NA!Partnerships! Sells!enzymes!via!distributors!including!major!partner!Andres!Pintaluba.!Customers! Global!Financial!Health! NA!Catalog!of!Enzymes! +!Toll!Manufacturing! :!!

GNC!Bioferm!manufactures!two!enzyme!product!mixtures!for!animal!feed!applications.!!The!target!animals!are!pigs!and!poultry.!

Products:!

Two!enzyme!mixtures!branded!Endofeed!and!Amylofeed!that!include:!

Beta:glucanase!

Xylanase!

!

' '

! ! !!


Habio'Bioengineering'(Sichuan)'

http://www.habio.net!!

Tangxum!Town,!Fucheng!District!

Mianyang!

Sichuan!P.C.!621000!

China!

Tel:!+86!28!8557!2969! ! Mobile:!+86!13880!252!909!!


Annual!Sales!approximately!US$!10!million;!>170!employees,!>20!in!R!&!D!



Enzyme!categories! Animal!feed,!food!and!industrial;!lipase!for!biodiesel!production!Expression!systems! 15!different!production!strains!Capacity/scale! Bulk.!!In:house!manufacturing.!Key!People! Mr.!Tao!Yang,!CEO;!Justine!Tong,!Head!of!Sales!and!Marketing!Partnerships! Partnerships!Cargill,!Kemin,!Samsung!Customers! China!and!Global,!selling!in!30!countries!Financial!Health! ++!Catalog!of!Enzymes! ++!Toll!Manufacturing! +!will!discuss!on!request!!

From!the!web!site:!“Habio!focuses!on!research!and!application!of!enzymes!in!feed!industry,!and!makes!a!long:term!commitment!in!promoting!and!practicing!high!efficient!solutions!of!developing!feed!resources!and!improving!feed!efficiency.!Habio!has!leading!producing!and!supplying!capability!for!bio:fermentation!products!in!Asia.!The!bio:fermentation!production!industrial!manufactory!has!been!finished!so!far!with!total!investment!100!million!RMB!and!fermentation!capability!over!15,000!MT!per!year.”!

Products:!Habio!Bioengineering!offers!the!following!enzymes!in!food,!feed,!and!industrial!grades.!The!company!also!offers!formulations!of!multiple!enzymes!for!poultry,!livestock,!ruminant,!egg:layers,!also!special!formulations!for!pigs!at!different!stages!of!growth.!

Products:!

Lipases,!including!Lipozyme!for!feed!and!Habio!Lipase!for!biodiesel!production!

! ! !!


Catalase!

Phytase!

Xylanase!

Galactosidase!

Beta:Mannanase!

Beta:Glucanase!

Amylases!

Proteases!

Cellulase!

Pectinase!

' '

! ! !!


Huvepharma'

www.huvepharma.com!!

5th!floor!

3a!Nikolay!Haytov!Str.!

Sofia,!1113!

Bulgaria!

Tel:!+359!2!862!53!31,!868!20!95!


1000+!employees!

Company!type! Private,!part!owned!by!Citigroup!Enzyme!sales!absolute!and/or!as!a!percentage!of!company!sales!


Enzyme!categories! Animal!feed!and!food.!Expression!systems! Trichoderma,!others!not!disclosed!Capacity/scale! Bulk.!!In:house!manufacturing!via!subsidiary!Biovet.!Key!People! Kiril!Domuschiev,!President!Partnerships! Huvepharma!is!the!majority!owner!of!Biovet!Customers! Global!Financial!Health! ++!Catalog!of!Enzymes! +!Toll!Manufacturing! :!!

From!a!press!release:!“Huvepharma®!is!a!privately!owned,!globally!operating!animal!health!and!nutrition!company!that!brands!a!broad!portfolio!of!products!used!in!the!swine,!poultry!and!cattle!production.!The!company!is!committed!to!develop,!manufacture,!service!and!market!animal!health!and!feed!additive!products!that!provide!economical!solutions!for!customers.!Huvepharma!has!manufacturing!facilities!as!well!as!sales!and!marketing!organizations!around!the!globe!which!establish!direct!relationships!with!intensive!livestock!customers.”!

Products:!

The!company!offers!about!15:20!formulations!consisting!of!the!following!enzymes:!

Beta:glucanases!

Xylanases!

Cellulases!

! ! !!


Hemicellulase!

Lipases!

Alpha:amylases!

Phytase!

Pectinase!

!

!

!

!

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! ! !!


IBEX'Technologies,'Inc.'

http://www.ibex.ca/!!

5485!Pare!Street,!Suite!100!

Montreal,!Quebec,!H4P!1P7!

Canada!

Tel:!514:344:4004!

Fax:!514:344:8827!



11:50!employees!

Company!type! Public:!IBT!Enzyme!sales!absolute!and/or!as!a!percentage!of!company!sales!

Major!portion!of!revenues!

Enzyme!categories! Recombinant!high:purity!proprietary!enzymes!(heparinases!and!chondroitinases)!

Expression!systems! Flavobacterium,heparinum!Capacity/scale! grams!to!kgs!Key!People! Paul!Baehr,!President!and!CEO!Partnerships! NA!Customers! NA!Financial!Health! ++!Catalog!of!Enzymes! +!(small!but!rare!offerings)!Toll!Manufacturing! :!!

From!the!most!recent!financial!report:!“The!Company,!through!its!wholly!owned!subsidiaries,!IBEX!Pharmaceuticals!Inc.!(Montreal,!QC)!and!Bio:Research!Products!Inc.!(North!Liberty,!IA),!manufactures!and!markets!enzymes!for!biomedical!use.!IBEX!also!manufactures!and!markets!a!series!of!arthritis!assays!which!are!widely!used!in!osteoarthritis!research.”!

Products:!

Heparinases!

Chondroitinases!

' '

! ! !!


Imperial'Jade'BioBTechnology'Co.,'Ltd.'

imperialjade12.en.china.cn!!

China!

Tel:!+86:951:13619572664!


11:50!employees!


Most!revenues!from!enzyme!sales!

Enzyme!categories! Food,!feed,!leather.!Expression!systems! Trichoderma,,Candida,lipolytica,,Aspergillus,,Bacillus,licheniformis,,Bacillus,

subtilis!Capacity/scale! Bulk.!!In:house!manufacturing.!Key!People! NA!Partnerships! NA!Customers! Global!Financial!Health! NA!Catalog!of!Enzymes! +!Toll!Manufacturing! :!!

Imperial!Jade!is!a!Chinese!company!that!probably!mostly!serves!the!Chinese!markets.!!Its!enzymes!have!appeared!in!at!least!two!peer:reviewed!publications.!

Products:!

Pectinase!

Lipase!

Proteases!

Xylanase!

Cellulase!

!

!

' '

! ! !!


Infinite'Enzymes'

www.infiniteenzymes.com!!

PO!Box!2654!!!!!!!!

State!University,!AR!!72467!!!!!!

USA!!

Tel:!+1:870:926:9566!



1:10!employees!


Revenues!from!government!grants!probably!dominate,!but!some!revenues!are!derived!from!enzyme!product!sales.!

Enzyme!categories! Cellulose:degrading!enzymes.!!First!product!is!IE:CBHI!or!Cellobiohydrolase!I!(Cel6A;!E.C.3.2.1.91)!from!Hypocrea,jecorina.!

Expression!systems! Corn!seed!expression!platform.!Capacity/scale! NA!Key!People! Elizabeth!Hood,!CEO!Partnerships! IE:CBHI!is!available!through!Sigma:Aldrich.!!Other!partners!are!Arkansas!

State!University,!Arkansas!Science!and!Technology!Authority,!Memphis!Bioworks!Foundation.!!Manufacturing!appears!to!be!done!at!Applied!Biotechnology!Institute.!!BioDimensions!is!an!investor.!

Customers! NA!Financial!Health! +!(estimated,!based!on!current!government!grant,!and!start!of!product!sales)!Catalog!of!Enzymes! +!(one!enzyme)!Toll!Manufacturing! :!!

From!the!company!website:!“Infinite!Enzymes!is!a!biotech!company!with!a!novel!genetic!technology!for!producing!low:cost,!plant:based!enzymes!for!converting!cellulosic!biomass!into!biofuels!and!other!biobased!products.!Infinite!Enzymes’!plant!genetic!technology!enables!the!production!of!cellulase!enzymes!in!the!embryo!(germ)!of!the!corn!kernel.!Using!transgenic!corn!as!a!“plant!factory”!for!producing!cellulase!enzymes,!Infinite!Enzymes!can!deliver!high:quality,!cost:competitive!cellulase!enzymes!on!a!commercial!scale!without!the!capital!intensive!requirements!and!environmental!costs!associated!with!existing!enzyme!production!through!microbial/fungal!fermentation!processes.”!!!

Products:!

Cellobiohydrolase!I!

! ! !!


InnoTech'MSU'

Web:!http://www.innotech:msu.com!!

Innovations!and!High!Technologies!MSU!Ltd.!

Tsymlyanskaya!ul.,!build!16,!office!96!

109559!Moscow!

Russia!

Tel:!+7(495)939!32!08!

Fax:!+7(495)939!27!42!

E:mail:[email protected]!!


Small!


Likely!significant!

Enzyme!categories! Biocatalysis!and!diagnostics.!Expression!systems! All!products!recombinant!in!E.,coli!!Capacity/scale! Likely!small,!in:house!production.!Key!People! Vladimir!Ivanovich!Tishkov,!Professor,!Head!of!the!Laboratory!of!Genetic!

Engineering!and!Protein!Design!:!Faculty!of!Chemistry!,!M.V.Lomonosov!Moscow!State!University,!Moscow,!Russian!Federation!

Partnerships! NA!Customers! NA!Financial!Health! NA!Catalog!of!Enzymes! +!(small!selection!of!possibly!unique!enzymes)!Toll!Manufacturing! NA!!

Billed!as!a!“Recombinant!Enzymes!Specialist.”!Founded!around!work!from!Moscow!State!University.!Anastasiya!Stepashkina!and!other!employees!presented!at!the!Russian!“Biocatalysis:2013”!conference.!!!

Products:!

Peroxidase!from!horseradish,!Peroxidase!from!tobacco!

Formate!Dehydrogenases!(2,!thermostable):!One!NAD+!specific;!one!NADP+!specific!!

D:Amino!acid!oxidase' !

! ! !!


Iris'Biotech'GmbH'

http://www.iris:biotech.de/!!

Waldershofer!Str.!49:51!!

D:95615!Marktredwitz!!

Germany!!

Tel:!+49:9231:9619:73!!

Fax:!+49:9231:9619:99!!

Email:!info@iris:biotech.de!!!


11:50!employees!


Small!

Enzyme!categories! Biocatalysis!!!Expression!systems! LIkely!does!not!manufacture!in!house.!Capacity/scale! Some!enzymes!available!in!up!to!multi:Kg!quantities.!!!Key!People! Oskar!Tropitzsch,!Managing!Director!(CEO)!Partnerships! Partnership!with!SPRIN!SpA!for!immobilization!of!enzymes.!!Works!with!

around!35!suppliers!for!many!of!its!products.!Customers! NA!Financial!Health! NA!Catalog!of!Enzymes! +++!Toll!Manufacturing! :!!

Iris!Biotech!is!a!distributor!of!enzymes!from!variuous!sources,!with!a!focus!on!the!biocatalysis!and!research!markets.!

From!the!company!website:!“IRIS!Biotech!is!specialized!in!reagents!for!Peptide!Synthesis,!PEGylation,!Life!Science!Research!and!Biocatalysis.!We!have!specific!know:how!and!production!capabilities!to!manufacture!and!supply!products…from!grams!to!multi:ton!lots.”!

Products:!

Immobilized!and!soluble!enzymes!in!kits!or!individually!including:!

Lipases!

! ! !!


Hydroxynitrile!lyases!

Inulinase!


D:hydantoinase!

Carbamoylase!!

Penicillin!G!amidase!

Collagenase!

Peroxidase!

Nitroreductase!

Phytase!

Tannase!

Esterases!

Proteases!

Amylases!

Cellulase!

Chloroperoxidase!

Laccase!

Lactase!!

Alcohol!oxidase!

Amidase!

Cytochrome!P450s!

Ene!reductases!

Epoxide!hydrolases!

Formate!dehydrogenase!

Ketoreductases!

! ! !!



Transaminases!

Nitrilases' '

! ! !!


JenaBioScience'GmbH!

http://www.jenabioscience.com!!

Löbstedter!Str.!78!

07749!Jena!

Germany!

Tel:!+49:3641:46!49!52!

Fax:!+49:3641:46!49!91!!



ca.!35!employees!


Small!!

Enzyme!categories! Molecular!biology!and!life!sciences!Expression!systems! NA!Capacity/scale! mg!to!Kg!scale.!!Some!in:house!production!likely.!Key!People! Mathias!Grün,!CEO!and!Co:Founder!Partnerships! NA!Customers! NA!Financial!Health! ++!(estimation!based!on!business!model!and!growth)!Catalog!of!Enzymes! ++!(w/comment)!Toll!Manufacturing! :!!

From!the!website:!“Jena!Bioscience!serves!three!major!client!groups:!!Research!laboratories!at!universities,!industry,!government,!hospitals!and!medical!schools;!Pharmaceutical!industry!in!the!process!from!lead!discovery!through!to!pre:clinical!stages;!and!Laboratory!&!diagnostic!reagent!kit!producers!and!re:sellers.!!Jena!Bioscience’s!products!include!nucleosides,!nucleotides!and!their!non:natural!analogs,!recombinant!proteins!&!protein!production!systems,!reagents!for!the!crystallization!of!biological!macromolecules!and!tailor:made!solutions!for!molecular!biology!and!biochemistry.!“!

Products:!

Restriction!Enzymes,!DNA!and!RNA!Polymerases,!Ligases!

Phosphatases!,!Kinases,!Nucleases!

Topoisomerases!

! ! !!


Jiangsu'Boli'Bioproducts'Co.'Ltd'

http://www.bolibio.com/!!

93!Yangzhou!Road!

Jiangyan!Economic!Development!Zone!

Jiangsu!Province!

PR!China!

Tel:!+86:151!5221!3005!

Fax:!+86:(0)523:8207:8002!



Probably!50!or!more!employees.!



Enzyme!categories! Applications!in!fuel!ethanol!production,!grain!processing,!food!baking,!brewing,!textiles!and!animal!feed.!!!

Expression!systems! NA!Capacity/scale! 30,000!metric!tons!annual!in:house!production!Key!People! NA!Partnerships! NA!Customers! NA!Financial!Health! NA!Catalog!of!Enzymes! ++!Toll!Manufacturing! :!!

From!the!website:!“Boli!Bioproduct’s!enzyme!products!can!be!divided!into!Technical!Grade!and!Food!Grade,!and!are!available!in!both!liquid!and!solid!(powder)!forms.!!Among!the!many!varied!applications!for!these!enzymes!are:!!starch!processing,!animal!and!plant!hydrolysis,!baking,!and!the!production!of!food!and!beverages,!feed,!fuel!ethanol,!textiles,!and!paper.”!

Products:!

Glucoamylase,!Alpha:amylase,!Beta:glucanase,!Catalase!

Protease!

! ! !!


Jiangsu'OGO'Biotech'Co.,'Ltd.'

www.ogo:biotech.com!!

No.17!Kangping!Rd!

Economic!Development!Zone!

LiyangJiangsu,!Liyang,!Jiangsu!

China!

Tel:!+86:0519:87921088!!

Email:!ogo@ogo:biotech.com!!


101:500!employees!


Most!to!all!revenues!from!enzyme!sales!

Enzyme!categories! Carbohydrate!hydrolysis.!Expression!systems! NA!Capacity/scale! Bulk.!!In:house!production!Key!People! NA!Partnerships! NA!Customers! NA!Financial!Health! NA!Catalog!of!Enzymes! +!Toll!Manufacturing! :!!

Enzyme!manufacturer.!!Website!is!only!available!in!Chinese.!

Products:!

Glucoamylase!

Alpha:amylases!

Xylanase!

!

!

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! ! !!


Jinan'Tiantianxiang'Co.,'Ltd.'

http://www.jnttx.com/!!

China!

Tel:!+86:531:87159986!

Fax:!+86:531:87950220!



NA!


Substantial!portion!of!revenues!

Enzyme!categories! Animal!nutrition!Expression!systems! NA!Capacity/scale! Bulk.!!In:house!production!likely!Key!People! NA!Partnerships! NA!Customers! NA!Financial!Health! NA!Catalog!of!Enzymes! +!Toll!Manufacturing! :!!

From!the!website:!“Founded!in!1998,!Jinan!Tiantianxiang!Co.,!Ltd.!is!specialized!in!R&D,!production!and!service!of!feed!additives.!We!can!supply!feed!enzymes,!feed!flavors!and!other!feed!additives!to!the!feed!factories!in!China!and!abroad.”!

Products:!

Phytases!

Mannase!


Xylanase!!

!

' '

! ! !!


Johnson'Matthey'

http://www.jmcct.com/!!

Orchard!Road,!Royston,!Hertfordshire!

SG8!5HE!!

UK!

Tel:!+44(0)!1763!253000!



9,700!employees!worldwide!

Company!type! Public:!JMAT!Enzyme!sales!absolute!and/or!as!a!percentage!of!company!sales!

Small!

Enzyme!categories! Biocatalysis!Expression!systems! E.,coli,Capacity/scale! 150!Liter:Fermentation!capacity!Key!People! Neil!Carson,!CEO;!Gerard!Compagnoni,!General!Manager,!Catalysis!and!Chiral!

Technologies;!Fred!Hancock,!Technical!Director!Catalysis!and!Chiral!Technologies!!

Partnerships! NA!Customers! Global!Financial!Health! +++!Catalog!of!Enzymes! +!Toll!Manufacturing! :!!

In!2010,!Johnson!Matthey!entered!the!enzyme!market!through!its!acquisition!of!German!company!X:Zymes.!!X:Zymes!was!founded!in!2001!as!a!spin!out!from!Heinrich:Heine:University!in!Dusseldorf.!!The!company!was!small,!with!about!8!employees,!and!it!made!variants!of!enzymes!for!use!as!biocatatalyst!in!the!pharma!indusry.!!!The!enzymes!from!X:Zymes!are!now!offered!for!sale!through!Johnson!Matthey,!and!the!X:Zymes!name!is!no!longer!used.!!Johnson!Matthey!offers!a!range!of!enzyme!for!biocatalysis!rsearch!and!manufacturing,!and!also!offers!contract!screening!and!research!services!in!biocatlaysis.!!!Sites!for!R!&!D!in!biocatalysis!and!enzyme!development!are!maintained!in!Cambridge,!UK!and!Duesseldorf,!Germany.!

Products:!!

Sold!individually!and!in!screening!kit!formats:!

! ! !!


Alcohol!dehydrogenases!(ketoreductases)!

Esterases!

Lipases!

Aldehyde!reductases!

Aldehyde!dehydrogenases!

Ene!reductases!

Transaminases!

NAD(P)!cofactor!regeneration!enzymes!

!

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! ! !!


Kemikalia'AB'

www.kemikalia.se!!

LILLA!VÄSTERGATAN!1!274!32!SKURUP!

Sweden!

Tel:!+46:411:49750!

Fax:!+46:411:49760!



15!employees!

Company!type! Private.!!Subsidiary!of!CH!Trading!GmbH!in!Austria!Enzyme!sales!absolute!and/or!as!a!percentage!of!company!sales!


Enzyme!categories! Dairy!enzymes!Expression!systems! Extraction!from!animal!tissue,!Kluyveromyces,lactis!Capacity/scale! Bulk.!!In:house!production!likely.!Key!People! NA!Partnerships! NA!Customers! EU!Financial!Health! NA!Catalog!of!Enzymes! +!Toll!Manufacturing! :!!

Kemikalia!specialized!in!ingredients,!chemicals,!and!specialty!products!for!the!dairy!industry.!

Products:!

Chymosin!

Pepsin!

Lipase!

Lysozyme!

Beta:galactosidase!

!

!

! ! !!


Kemin'

www.kemin.com!!

2100!Maury!Street!!

Des!Moines,!IA!50309!!

USA!

Tel:!+1:515:559:5100!

Tel:!+1:800:777:8307!

Fax:!+1:515:559:5232!


1600!employees,!$520!million!annual!sales!


Small!

Enzyme!categories! Animal!feed!enzyme!mixtures!under!the!trade!name!Kemzyme!Expression!systems! NA!Capacity/scale! Bulk.!!In:house!production!unlikely.!Key!People! Chris!Nelson,!CEO!Partnerships! NA!Customers! Global,!offices!in!60!countries.!Financial!Health! +++!Catalog!of!Enzymes! +!Toll!Manufacturing! :!!

From!website:!“Using!superior!science,!Kemin!manufactures!more!than!500!specialty!ingredients!that!deliver!important!nutrition!and!health!benefits!through!products!consumed!by!people!and!animals.”!

Products:!

Mixtures!of:!

Amylases!

Pullulanase!

Glucoamylase!

Proteases!

! ! !!


Pectinase!

Xylanase!

Cellulase!

Beta:glucanase' !

! ! !!


Kerry'Group/Kerry'Americas'

http://www.kerry.com!!

3400!Millington!Road!Beloit!

Wisconsin!53511!!

USA!


10,000+!

Company!type! Public:!KRYAF!Enzyme!sales!absolute!and/or!as!a!percentage!of!company!sales!

Small!

Enzyme!categories! Food!enzymes!for!baking,!beverages,!and!dairy.!!Expression!systems! NA!Capacity/scale! Bulk.!!In:house!production!unlikely.!Key!People! NA!Partnerships! NA!Customers! Global!Financial!Health! +++!Catalog!of!Enzymes! +!Toll!Manufacturing! :!!

Kerry!Americas!is!part!of!the!Kerry!Group!which!is!based!in!Ireland.!!The!Kerry!group!is!a!manufacturer!of!food!ingredients!and!foods.!!!

Products:!

Amylases!

Glucanase!

Xylanase!

Invertase!

Proteases!

Cellulase!


' '

! ! !!


Kiotechagil'

www.kiotechagil.com!!

Manton!Wood!Enterprise!Park!

Worksop!

Notts!

S80!2RS!

UK!

Tel:!+44!(0)!1909!537!387!

Fax:!+44!(0)!1909!478!919!



£13.0!million!annual!revenue.!

Company!type! Part!of!Anpario.!!Anpario!is!public!(Ticker:!ANP).!Enzyme!sales!absolute!and/or!as!a!percentage!of!company!sales!


Enzyme!categories! Animal!nutrition!Expression!systems! Penicillium,funiculosum,Capacity/scale! Bulk.!!In:house!production.!Key!People! Mike!Corbett,!Managing!Director!(CEO)!Partnerships! Many!distributors.!Customers! Global!Financial!Health! +++!Catalog!of!Enzymes! +!Toll!Manufacturing! :!!

From!the!company!website:!“Kiotechagil!supplies!high!performance!natural!feed!additives!to!the!aquaculture!and!agriculture!markets.!It!brings!together!the!expertise!of!Kiotech!and!Agil!across!the!three!key!protein!sources!of!poultry,!pig!and!fish.!Kiotechagil!has!a!distribution!network!in!over!50!countries!and!aims!to!be!the!leading!player!in!supplying!high!performance!natural!feed!additives!:!enhancing!health,!growth!and!sustainability!in!aquaculture!and!agriculture.”!

Products:!

Kiotechagil!sells!mixtures!of!enzymes!for!pig!and!poultry!under!the!brand!Feedzyme.!!These!mixtures!contain!Beta:glucanase,!Xylanase,!Phytase' !

! ! !!


Kiwienzyme.com'Ltd'

www.kiwienzyme.com!!

PO!Box!48076!

Silverstream!5018!

New!Zealand!

Tel:!+64:4!528!8854!!


Small!



Enzyme!categories! Meat,!cosmeticals,!human!health,!baking.!Expression!systems! Extraction!from!kiwi!fruit.!Capacity/scale! Bulk.!!In:house!production.!Key!People! Garrick!Wells,!Director!Partnerships! NA!Customers! NA!Financial!Health! NA!Catalog!of!Enzymes! +!Toll!Manufacturing! :!!

The!company!is!based!in!New!Zealand,!as!the!name!suggests.!Kiwienzyme!produces!and!sells!actinidin,!which!is!a!protease!from!kiwi!fruit.!!!

Products:!

Actinidin!

!

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Lactosan'GmbH'

http://www.lactosan.at/!!

Industriestraße!West!5!

A:8605!Kapfenberg!

Austria!

Tel:!+43!(0)386232602:10!!!!

Fax:!+43!(0)386232602:4!



50!employees!

Company!type! Private,!owned!by!Schaumann!since!1994.!Enzyme!sales!absolute!and/or!as!a!percentage!of!company!sales!

No!off!the!shelf!enzymes,!enzyme!revenues!through!custom!manufacturing.!

Enzyme!categories! None!Expression!systems! Lactic!acid!bacteria,!many!other!organisms!customer!specified!Capacity/scale! Multi:ton,!in:house!production.!Key!People! Hans:Peter!Lettner,!Technical!Director!Partnerships! NA!Customers! Codexis!has!used!Lactosan!to!produce!essentially!all!of!their!enzymes!on!

large!scale!Financial!Health! ++!(estimated)!Catalog!of!Enzymes! :!Toll!Manufacturing! +++!!

Lactosan!produces!lactic!acid!bacteria!cultures,!and!conducts!contract!manufacturing!for!these!and!other!products!including!enzymes!under!GMP!/!cGMP!standards.!!The!company!is!a!contract!manufacturer!of!enzymes!sold!by!Codexis.!!Company!has!produced!custom!transaminases,!ketoreductases,!monoamine!oxidases,!many!others.!

!

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Laffort'

http://www.laffort.com/!!

CS!61!611!

33072!BORDEAUX!CEDEX!15!

France!

Tel:!+33!556!86!53!04!!

Fax:!+33!556!86!30!50!



Medium!to!large!organization!


Important!minortiy!revenue!stream!

Enzyme!categories! Winemaking!Expression!systems! NA!Capacity/scale! Bulk.!!In:house!production!unlikely.!Key!People! NA!Partnerships! NA!Customers! Global!Financial!Health! NA!Catalog!of!Enzymes! ++!Toll!Manufacturing! :!!

Laffort!supplies!the!wine!industry!with!yeasts,!fermentation!aids,!bacteria,!enzymes,!clarification!and!stabilization!aids,!enzymes,!tannins,!and!wood!products.!!!

Products:!

Lysozyme!

Pectinases!

Beta:glucanase!

Beta:glucosidase!

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Lallemand'

http://www.lallemand.com/!!

1620!rue!Prefontaine!

Montreal!

Quebec!H1W!2N8!

Canada!

Tel:!+1!514!522!2133!



1001:5000!


An!important!minority!of!revenues!are!from!enzymes.!

Enzyme!categories! Winemaking,!brewing,!biofuels,!and!baking.!!!Expression!systems! Mostly!Trichoderma!and!Aspergillus!Capacity/scale! Bulk.!!In:house!production!unlikely.!Key!People! NA!Partnerships! Partnered!with!Mascoma!to!develop!a!GMO!yeast!Customers! Global!Financial!Health! +++!Catalog!of!Enzymes! ++!Toll!Manufacturing! :!!

From!the!company!website:!“Lallemand!Inc.!is!a!privately!owned!company!that!researches,!develops,!produces!and!markets!yeasts,!bacteria!and!related!products!with!the!aim!of!reproducing,!managing!and!optimizing!natural!fermentation!processes!in!agri:food!industries.”!!Lallemand’s!business!units!are!animal!nutrition,!baking,!bio:ingredients,!brewing,!biofuels!&!distilled!spirits,!health!solutions,!manufacturing!services,!oenology,!pharma,!and!plant!care.!

Products:!

Pectinases!

Beta:glucosidases!

Rhamnosidase!

! ! !!


Apiosidase!

Lysozyme!

Polygalacturonases!

Arabinofuranosidase' !

! ! !!


LamotheBAbiet'

http://www.lamothe:abiet.com/!!

Z.A.!Actipolis,!avenue!Ferdinand!de!Lesseps!

33610,!CANEJAN!/!BORDEAUX!

France!

Tel:!+33!5!57!77!92!92!

Fax:!+33!5!56!86!40!02!

Email:!contact@lamothe:abiet.com!!


Large!


Small!but!important!

Enzyme!categories! Winemaking!Expression!systems! NA!Capacity/scale! Bulk.!!No!in:house!production.!Key!People! NA!Partnerships! The!company!carries!the!Novozymes!family!of!winemaking!enzymes,!and!

also!acquires!their!enzyme!supply!from!Novozymes.!Customers! Global!Financial!Health! NA!Catalog!of!Enzymes! ++!Toll!Manufacturing! :!!

Lamothe:Abiet!offers!a!wide!range!of!consumable!materials!for!winemaking!including!yeasts,!fermentation!additives,!fining!agents,!stabilizers,!taste!enhancers,!and!wood!products.!

Products:!

Polygalacturonases!

Beta:glucosidases!

Beta:glucanases!

!

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Lanxess'GmbH'

www.lanxess.com!!!

Kennedyplatz!1!

50569!Köln!

Germany!

Tel:!+49!(0)!221!/!8885:0!!

Email:!lanxess:[email protected]!!

Year!Founded! 2004!(spun!off!from!Bayer!AG)!Size!($!or!employee!count!or!both)!

17,000!employees!

Company!type! Public:!LXS!Enzyme!sales!absolute!and/or!as!a!percentage!of!company!sales!

Very!small!

Enzyme!categories! Leather!!Expression!systems! NA!Capacity/scale! Bulk.!!No!in:house!production.!Key!People! Axel!Heitmann,!CEO!Partnerships! Lanxess!invested!in!enzyme!company!Evocatal.!!Its!leather!enzymes!were!

developed!in!partnership!with!Novozymes!Customers! Global!Financial!Health! +++!Catalog!of!Enzymes! +!Toll!Manufacturing! :!!

Lanxess!is!a!manufacturer!of!specialty!chemicals,!plastics,!and!rubber.!!It!has!recently!entered!the!enzymes!area!by!investing!in!Evocatal,!and!by!developing!and!offering!enzymes!for!leather!processing.!!!!!

Products:!

Peltec!X:Zyme!S!(glucosidase)!!

Peltec!X:zyme!U!(protease)!

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Larbus's.a.'

http://www.larbus.com/!!

c/!Lorenzo!Gonzalez,!9!bajo.!

28017!–!Madrid!

Spain!

Tel:!+34!91!408!30!68!

Fax:!+34!91!407!86!74!



NA!


Significant!portion.!!!

Enzyme!categories! Dairy,!fruit!juice,!meat!processing.!Expression!systems! NA!Capacity/scale! Bulk.!!No!in:house!production.!Key!People! NA!Partnerships! Larbus!distributes!enzymes!and!materials!for!third!parties!and!probably!

makes!nothing!in!house.!!Its!suppliers!include!Verenium!and!DuPont!Industrial!Biosciences.!

Customers! NA!Financial!Health! NA!Catalog!of!Enzymes! ++!Toll!Manufacturing! :!!

From!the!website:!“ARBUS,!S.A.!has!been!more!than!twenty:five!years!operating!in!the![dairy]!sector.!Throughout!the!time,!it!has!been!consolidating!his!presence!in!this!sector,!and!extending!this!activity!to!other!sectors!like![meat],!and!more!recently!to!the!sector!of!juices!and!concentrates,!providing!the!necessary!additives!and!ingredients!for!these!industries.”!

Products:!

Proteases!

Chymosin!

Rennet!

! ! !!


Lysozyme!

Catalase!

Pectinases!

Cellulases!

Glucoamylases!

Amylases!

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Lentikats'Biotechnologies'

http://www.lentikats.eu!!

Office!Building!ARGO!

Evropska!846/176a,!160!00!Prague!6!

Czech!Republic!

Tel:!+420!255!710!680!

Fax:!+420!255!710!699!!



11:50!employees!


NA!

Enzyme!categories! NA!Expression!systems! NA!Capacity/scale! Production!scale!capable!of!Kg!amounts!in:house!Key!People! Ludek!Karasek,!CEO!Partnerships! Technology!is!licensed!from!geniaLab!GmbH.!!Partnered!with!Enantis!for!

haloalkane!dehalogenase!project.!!Partnered!a!project!for!wastewater!treatment!with!BASF.!!!

Customers! NA!Financial!Health! ++!(estimated!based!on!multiple!partnerships!and!investors,!and!consistent!

progress)!Catalog!of!Enzymes! :!Toll!Manufacturing! +!(immobilizes!enzymes!on!contract,!does!not!express!them)!!

Lentikats!specializes!in!immobilizing!enzymes!and!microorganisms!in!its!unique!lentil:shaped!polymer!capsules.!!This!immobilization!typically!gives!the!enzymes!increased!stability.!!The!capsules!are!made!out!of!non:toxic!poly:vinyl!alcohol!and!are!3:4!mm!in!diameter!and!200:400!µm!thick.!!The!company!targets!applications!in!pharmaceuticals,!food,!distillery,!and!waste:water!treatment.!!LentiKats!has!a!manufacturing!plant,!head!offices,!and!research!and!development!lab!space,!suggesting!that!the!company!has!grown!successfully.!!Several!academic!publications!have!appeared!demonstrating!the!superiority!of!LentiKats’!immobilized!systems!over!non:immobilized!variants.!!!

! !

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Leveking'Enzymes'

http://www.levekingenzymes.com/!!

112:113,!Bio:!Incubator!Building!2!

Gaoxinzhong!One!Road!!

High!&!New!Technology!

Garden!!!District,!Shenzhen!!

China!

Tel:!+86:755:26031010!ext!804!

Fax:!+86:755:26031910!



51:200!


Most!to!all!sales!are!enzymes.!

Enzyme!categories! Animal!feed,!baking,!paper!Expression!systems! NA!Capacity/scale! Bulk.!!In:house!production.!Key!People! NA!Partnerships! NA!Customers! LEVEKING!enzyme!are!being!exported!to!over!22!countries,!among!which!are!

Asia!(India,!Singapore,!Thailand,Pakistan,!Korea!,!Vietnam!,Philippines,!Malaysia,etc.)!South!America(!Brazil,!Argentina,!Peru!…)!

Financial!Health! NA!Catalog!of!Enzymes! ++!Toll!Manufacturing! NA!!

From!the!company!website:!“Established!in!2001,!LEVEKING!has!emerged!as!a!best!:known!worldwide!leader!in!the!field!of!Enzymes!for!Animal!Feed,!Baking!industry!and!Paper!Industry.!Moreover,!Leveking!is!the!first!enterprise!which!use!Lipase!in!feed!industry!in!China;!it!is!approved!by!Ministry!of!Agriculture!of!the!People’s!Republic!Of!China!and!obtained!the!product!licence!for!feed!additives!and!the!Product!Approved!No.:!Feed!Additives(2005)!1861.”!

!

! ! !!


Products:!

Lipases!

Xylanases!

Phytase!

Alpha:amylases!

Mannase!

Transglutaminase!

Protease' !

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LibraGen'

http://www.libragen.com/!!

Bâtiment!Canal!Biotech!1!

3!rue!des!Satellites!

31400!Toulouse!

France!

Tel.:!+33!(0)5!62!19!32!90!

Fax:!+33!(0)5!61!73!27!56!



15!employees!

Company!type! Private,!owned!by!cosmetic!firm!Induchem!Enzyme!sales!absolute!and/or!as!a!percentage!of!company!sales!

Small!

Enzyme!categories! Biocatalysis,!cosmetics!Expression!systems! NA!Capacity/scale! Pilot!scale,!grams!to!kgs!Key!People! Marie:Joëlle!Gaufrès,!Deputy!CEO!Partnerships! Libragen!has!formed!past!industrial!partnerships!with!Pierre!Fabre,!

Minakem,!Yves!Rocher,!Yves!Saint!Laurent,!DSM,!and!Sanofi:Aventis.!!!Customers! NA!Financial!Health! NA!Catalog!of!Enzymes! ++!Toll!Manufacturing! +!(pilot!scale)!!

LibraGen!offers!transaminase!and!esterase!enzymes!individually!and!in!kits,!as!well!as!services!as!a!contract!research!organization.!!The!company!additionally!offers!cosmetical!products!and!chemical!building!blocks.!!The!services!that!LibraGen!offers!include!the!identification!of!new!enzymes!from!its!collection!of!metagenomic!DNA,!the!improvement!of!the!enzymes,!process!optimization!using!enzymes,!and!scale!up!of!the!processes!to!pilot!scale.!!LibraGen!lists!reactions!catalyzed!by!the!following!enzymes!among!its!capabilities:!transaminases,!esterases,!lipases,!oxidoreductases,!phosphorolases,!dehydrogenases,!nitrile!hydrolases,!ene!reductases,!and!glycosylation!enzymes.!!!

!

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Products:!

ChiralamineTM!family!of!25!transaminases!available!in!kits!or!individually!

MEGAesteraseTM!family!of!6!esterases!and!lipases!available!in!kits!or!individually!

Developed!Biocatalysts:!!

Libraries!of!enzymes!in!the!following!categories:!!

Lipases!

Transaminases!

Ene:Reductases!

Phosphatases!

Hydroxynitrilases!

Sulfatases!

Glucosidases!

!

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Life'Technologies'

http://www.lifetechnologies.com/!!

3175!Staley!Road!

Grand!Island,!NY!14072!

USA! !

Tel:!+1:800:955:6288!

Fax:!+1:800:331:2286!


Year!Founded! 2008!(with!the!merger!of!Invitrogen!and!Applied!Biosystems)!Size!($!or!employee!count!or!both)!

$3.8!billion!revenue!(2012),!10,000!employees!

Company!type! Public:!LIFE!Enzyme!sales!absolute!and/or!as!a!percentage!of!company!sales!

Very!small,!Life!Technologies!offers!over!50,000!total!products.!!

Enzyme!categories! Molecular!biology!enzymes!for!DNA!and!RNA!manipulation,!analysis,!and!amplification.!

Expression!systems! NA!Capacity/scale! Lab!scale.!!Some!in:house!production!likely.!Key!People! Gregory!T.!Lucier,!CEO!Partnerships! NA!Customers! Global,!in!180!countries.!Financial!Health! +++!Catalog!of!Enzymes! +!(standard!molecular!biology!tools)!Toll!Manufacturing! +!(Life!has!a!protein!expression!services!team)!!

Life!Technologies!agreed!to!be!acquired!by!Thermo!Fisher!Scientific!for!over!$13!billion!in!April!2013.!

Products:!!

Extensive!line!of!enzymes!for!research!in!the!following!categories:!

DNA!Polymersases,!Restriction!enzymes,!Proteases,!Phosphatases,!Kinases,!Ligases,!Topoisomerase,!DNA!and!RNA!nucleases!

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Lonza'

http://www.lonza.com/!!

Muenchensteinerstrasse!38!

4002!Basel!

Switzerland!

Tel:!+41!61!316!81!11!

Fax:!+41!61!316!91!11!



10,000!employees!

Company!type! Public:!LONN!Enzyme!sales!absolute!and/or!as!a!percentage!of!company!sales!

Very!small!

Enzyme!categories! Molecular!biology.!Expression!systems! Pseudomonas,atlantica,Capacity/scale! Bulk!Key!People! Richard!Ridinger,!CEO!Partnerships! NA!Customers! Global!Financial!Health! +++!Catalog!of!Enzymes! +!!Toll!Manufacturing! :!!

From!the!company!website:!“Founded!in!1897!in!the!Swiss!Alps,!Lonza!today!is!one!of!the!world’s!leading!life!sciences!companies.!!We!harness!science!and!technology!to!create!products!that!make!people’s!lives!safer!and!healthier!and!that!enhance!the!overall!quality!of!life!and!well:being.!!!Our!products!range!from!active!pharmaceutical!ingredients!and!stem:cell!therapies!to!drinking!water!sanitizers,!from!Vitamin!B!compounds!and!other!nutritional!ingredients!to!the!custom!development!of!agricultural!products,!and!from!industrial!preservatives!to!microbial!control!solutions!that!combat!dangerous!viruses,!bacteria!and!other!pathogens.”!

Product:!

Beta:agarose!(for!gel!extraction!in!the!life!sciences)!

! ! !!


Lucigen!

http://lucigen.com/!!

2905!Parmenter!Street!

Middleton,!WI!53562!

USA!

Tel:!+1:608:831:9011!

Fax:!+1:608:831:9012!



40!


Enzymes!are!a!portion!of!a!much!broader!range!of!products!and!services!in!life!sciences.!

Enzyme!categories! DNA!polymerases,!DNA!modifying!enzymes,!carbohydrate!hydrolytic!enzymes.!!!

Expression!systems! E.,coli!for!DNA!polymerases!and!DNA:modifying!enzymes.!!Dictyoglomus,turgidum,,Bacillus,,Clostridium,thermocellum,!and!an!undisclosed!strain!for!carbohydrate!hydrolytic!enzymes.!

Capacity/scale! Lab!scale!Key!People! David!Mead,!Founder!and!CEO!Partnerships! Global!distribution!network.!!In!2006,!Lucigen!spun!off!C5.6!Technologies,!

and!this!spin!off!company!supplies!the!carbohydrate!hydrolytic!enzymes.!!!Customers! Global!Financial!Health! ++!Catalog!of!Enzymes! ++!Toll!Manufacturing! :!!

From!the!company!website:!“Located!in!Middleton,!Wis.,!Lucigen!delivers!advanced!molecular!biology!products!and!services!to!life!scientists!by!inventing!solutions!to!the!most!difficult!problems!in!DNA!cloning,!amplification,!protein!expression,!and!next!generation!sequencing.!With!a!focus!on!simplifying!genomic!research,!Lucigen!offers!a!wide!selection!of!cloning!kits,!competent!cells,!and!enzymes!that!enable!scientists!to!quickly!and!easily!complete!even!the!most!challenging!molecular!biology!experiments.”!

!

!

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Products:!

RND!nuclease!

DNA!Polymerases!

Cellulases!

Xylanases!

Curdlanase!

Beta:mannanase!

Licheninase!

Beta:galactosidase!


Alpha:glucuronidase!

Cellobiohydrolases!

Beta:xylosidase!

Beta:glucanases!

Arabinfuranosidase!

! !

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Lumis'Biotech'Pvt.'Ltd.'

http://www.lumisbiotech.com/!!

501,!Arun!Chambers,!Tardeo!Road!

Mumbai!–!400034!

India!

Tel:!+91:22:6666!2690!/!91!/!92!/!93!/!94!

Fax:!+91:22:6740!2555!

Emails:[email protected];[email protected];[email protected]!!


Parent!company!has!2,400!employees!

Company!type! Private,!a!subsidiary!of!K:Genix!Group!Enzyme!sales!absolute!and/or!as!a!percentage!of!company!sales!

100%!

Enzyme!categories! Feed,!textiles,!food,!baking,!juice,!winemaking!and!brewing.!!!Expression!systems! Many,!both!solid!state!and!submerged!fermentations.!Capacity/scale! Bulk.!!In:house!production.!Key!People! NA!Partnerships! NA!Customers! NA!Financial!Health! NA!Catalog!of!Enzymes! ++!Toll!Manufacturing! :!!

From!the!company!website:!“Lumis!Biotech!is!one!of!the!foremost!enzyme!manufacturing!companies!in!Asia.!The!core!strength!of!Lumis!lies!in!Applied!Industrial!Enzymology.!We!have!designed!and!launched!certain!innovative!products!for!the!food,!feed!and!the!textile!industry!through!state:of:the:art!manufacturing!facilities,!high!tech!laboratory!equipments,!leading!edge!quality!assurance!system!and!industry!specific!knowledge.!This!makes!Lumis!an!unique!enzyme!company!which!helps!to!reduce!production!cost!and!increase!efficiency!of!the!process.”!

Products:!

Hemicellulase!

Amyloglucosidase!

Amylases!

! ! !!


Pectinases!

Cellulases!

Laccases!

Catalase!

Phytase!

Xylanase!

Beta:glucanase!

Lipases!

Mannase!

Galactosidase!

Proteases!

Papain!

!

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Lybradyn,'Inc.'

http://www.lybradyn.com/!!

125!Windsor!Dr.,!Ste.!126!

Oak!Brook,!IL!60523!

USA!

Tel:!+1:630:575:8313!

Fax:!+1:630:282:7117!



1:10!employees!


Very!small!

Enzyme!categories! Selective!hydrolysis,!chiral!synthesis!(esterase,!lipase!and!racemase),!anti:biofilm!(lactonase),!and!pesticide/chemical!weapons!detoxification!and!detection!(organophosphorus!hydrolase)!

Expression!systems! E.,coli,,Pseudomonas,,Bacillus,,Thermus,!cyanobacteria,!yeast!Capacity/scale! Small,!in:house!production.!Key!People! John!Aikens,!Co:Founder!and!CEO;!Wendy!Aikens,!Co:Founder!and!President!Partnerships! NA!Customers! NA!Financial!Health! NA!Catalog!of!Enzymes! +!Toll!Manufacturing! +!!

Lybradyn!is!a!small!company!that!does!contract!R+D!for!genetic!engineering,!protein!expression,!biocatalyst!process!development,!and!consulting!in!these!areas.!

Products:!

Esterase,!Lipase,!Racemase,!Lactonase,!Organophosphate!hydrolase!

!

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Lyven'

www.lyven.com!!

Zac!Normandial!

11!avenue!du!pays!de!Caen!

14460!Columbelles!

France!

Tel:!+33:2:31:35:05:30!!

Fax:!+33:2:31:34:54:49!

Email:!lyven@soufflet:group.com!!


About!50!employees!

Company!type! Subsidiary!of!Soufflet!Group!Enzyme!sales!absolute!and/or!as!a!percentage!of!company!sales!

Nearly!all!sales!are!enzymes!

Enzyme!categories! Feed,!brewing!and!winemaking,!textiles,!baking,!fruit!and!juice.!Expression!systems! Strains!of!Aspergillus,,Bacillus,,Trichoderma.!!Extraction!from!plant!and!

animal!tissue.!Capacity/scale! Bulk.!!In:house!production.!Key!People! NA!Partnerships! Distributes!through!sister!company!AIT!Ingredients!and!Acatris.!Customers! Europe!Financial!Health! NA!Catalog!of!Enzymes! ++!Toll!Manufacturing! :!!

Lyven!is!a!manufacturer!of!enzymes!that!are!distributed!in!Europe!by!AIT!Ingredients!and!Acatris.!

Products:!

Pentosanases/xylanase!

Beta:glucanases,!

Proteases!

Pectinases!

! ! !!


Cellulases!

Amyloglucosidases!

Alpha:amylases!

Phytase!

Glucose!oxidase!

!

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M'L'CHEMICALS'(INDIA)'PVT'LTD.'

www.mlindia.com!!

REAL!CHAMBERS!

2ND!FLOOR,FLAT!NO:6!

65/30,MADDOX!STREET,CHOOLAI!

CHENNAI!:!600!112!

TAMIL!NADU!

India!

Tel:!+!91!:!44!:!65197000!

Fax:!+!91!:!44!:!42064315!



1:10!employees!


Most!revenues!from!enzyme!sales!

Enzyme!categories! Leather!and!textiles!Expression!systems! Bacillus,,Trichoderma,Capacity/scale! Bulk.!!In:house!manufacture.!Key!People! NA!Partnerships! Dealers!throughout!India!Customers! India!Financial!Health! NA!Catalog!of!Enzymes! ++!Toll!Manufacturing! :!!

M!L!CHEMICALS!(INDIA)!PVT!LTD.!serves!the!Indian!leather!and!textile!industries.!!The!company!manufactures!and!sells!enzymes!and!a!limited!set!of!chemicals.!!!

Products:!

8!enzyme!formulations!that!include:!

Proteases,!Lipases,!Alpha:amylases,!Cellulases!

! ! !!


Maps'Enzymes'Limited'

http://www.mapsenzymes.com/!!

302,!Shapath:3!

S.G.!Road!

Ahmedabad!380054!

India!

Tel:!+91!(79)!26859971:74!

Fax:!+91!(79)!26859975!



150!enployees!


Major!portion!of!revenues.!

Enzyme!categories! Textiles,!leather,!baking,!alcohol,!brewing,!detergent,!starch!and!animal!feed!Expression!systems! NA!Capacity/scale! Bulk.!!In:house!production.!Key!People! Mr.!Piyush!Palkhiwala,!Chairman!&!Managing!Director;!Dipal!Palkhiwala,!

Head!of!Business!Operations;!Bhavin!Palkhiwala,!Head!of!Finance !Partnerships! NA!Customers! Global!Financial!Health! NA!Catalog!of!Enzymes! ++!Toll!Manufacturing! NA!!

From!the!company!web!site:!“Maps!is!a!pioneer!biotechnology!company!producing!enzymes!and!microorganisms!since!1975.!Today!we!are!listed!among!the!Top!50!Biotech!companies!in!India.!With!a!sales!network!spread!across!4!continents!in!22!countries!and!a!product!portfolio!of!60+!products!for!more!than!10!different!industries,!we!provide!biotech!solutions!to!improve!industrial!performance!and!quality.”!!

Products:!

About!60!product!formulations!are!sold!including!formulations!of!the!following:!

Cellulases!

! ! !!


Proteases!

Phytase!

Catalase!

Glucoamylase!

Glucanases!

Xylanases!

' '

! ! !!


Megazyme'International'Ireland'

http://www.megazyme.com/!!

Bray!Business!Park!

Bray,!Co.!Wicklow!

Ireland!

Tel:!+353:1:2861220!!

Fax:!+353:1:2861264!!



About!35!employees!


Large!portion!of!revenues!from!enzyme!sales.!98%!of!sales!are!exports.!

Enzyme!categories! Diagnostics,!analytics,!animal!feed,!baking,!biofuels,!detergents,!brewing!and!winemaking,!dairy,!textiles.!

Expression!systems! Many!Capacity/scale! Grams!to!kgs!Key!People! Barry!McCleary,!CEO!Partnerships! Many!distributors!Customers! Global!Financial!Health! NA!Catalog!of!Enzymes! +++!Toll!Manufacturing! :!!

From!the!company!website:!“Megazyme!International!Ireland!is!a!privately!owned!biotechnology!company!specialising!in!the!development,!manufacture!and!supply!of!diagnostic!test!kits!and!reagents!for!the!food,!feed,!dairy!and!wine!industries.!!Megazyme!markets!a!range!of!over!500!products….”!

Products:!

E:ACSBS!RecAcetyl:CoA!synthetase!(B.!subtilis)!

E:OGLYEF!Recendo:α:N:Acetylgalactosaminidase!(E.!faecalis)!

E:ANAGM!Recα:N:Acetylgalactosylaminidase!(microbial)!

E:BNAHEX!Recβ:N:Acetylhexosaminidase!(microbial)!

! ! !!


E:AXEAO!RecAcetylxylan!esterase!(Orpinomyces!sp.;!regular)!

E:AXEAOB!RecAcetylxylan!esterase!(Orpinomyces!sp.;!large)!

E:ACPEC!RecAcid!phosphatase!(E.!coli)!

E:AMPK!RecAdenylate!kinase!(myokinase)!(prokaryote)!

E:ADHEC!RecAlcohol!dehydrogenase!(E.!coli)!

E:ALGLS!RecAlginate!lyase!(Sphingomonas!sp.)!

E:ALPEC!RecAlkaline!phosphatase!(E.!coli)!

E:ANAAM!α:Amylase!(A.!oryzae)!

E:BAASS!α:Amylase!(Bacillus!amyloliquefaciens)!

E:BLAAM!α:Amylase!(B.!licheniformis)!

E:BLAAM100!α:Amylase!(B.!licheniformis)!

E:PANAA!α:Amylase!(Porcine!Pancreatic)!

E:BARBL50!β:Amylase!(barley;!liquid)!

E:BARBL100!β:Amylase!(barley;!liquid)!

E:BARBP!β:Amylase!(barley;!powder)!

E:BAMBC!Recβ:Amylase!(B.!cereus)!

E:AMGDF!Amyloglucosidase!(A.!niger)!

E:AMGDF100!Amyloglucosidase!(A.!niger)!

E:AMGFR100!Amyloglucosidase!(A.!niger)!

E:AMGFR500!Amyloglucosidase!(A.!niger)!

E:AMGPU!Amyloglucosidase!(Rhizopus!sp.)!

E:EARAB!endo:1,5:α:L:Arabinanase!(A.!niger)!

E:AFASE!α:L:Arabinofuranosidase!(A.!niger)!

E:AFAM2!Recα:L:Arabinofuranosidase!(novel!specificity)!

E:ABFCJ!Recα:L:Arabinofuranosidase!(C.!japonicus)!

! ! !!


E:ABFCT!Recα:L:Arabinofuranosidase!(C.!thermocellum)!

E:ARBACJ!Recendo:/exo:Arabinanase!(C.!japonicus)!

E:ASNEC!RecAsparaginase!(E.!coli)!

E:DIPEP!Recα:Aspartyl!dipeptidase!(E.!coli)!

E:CBHI!Cellobiohydrolase!I!(T.!longibrachiatum)!

E:CELAN!Cellulase!(endo:1,4:β:D:glucanase)!(A.!niger)!

E:CELBA!RecCellulase!(endo:1,4:β:D:glucanase)!(B.!amyloliquefaciens)!

E:CELTM!RecCellulase!(endo:1,4:β:D:glucanase)!(T.!maritima)!

E:CELTE!Cellulase!(endo:1,4:β:D:glucanase)!(T.!emersonii)!

E:CELTR!Cellulase!(endo:1,4:β:D:glucanase)!(T.!Longibrochiatum)!!

E:CITEC!RecCitrate!synthase!(E.!coli)!

E:CREA!RecCreatinase!(Bacillus!sp.)!

E:CMPK!RecCytidylate!kinase!(prokaryote)!

E:DIAEC!RecDiaphorase!(E.!coli)!

E:FAERU!RecFeruloyl!esterase!(rumen!microorganism)!

E:FAEZCT!RecFeruloyl!esterase!(C.!thermocellum)!

E:FDHCB!RecFormate!dehydrogenase!(C.!boidini)!

E:FRMXLQ!Fructanase!mixture!(purified;!liquid)!

E:FUCTM!Recα:Fucosidase!(thermostable)!(T.!maritima)!

E:FUCM!1,2:α:L:Fucosidase!(microbial)!

E:EGALN!endo:1,4:β:D:Galactanase!(A.!niger)!

E:GALCJ!Recendo:1,4:β:D:Galactanase!(C.!japonicus)!

E:GALCT!Recendo:1,4:β:D:Galactanase!(C.!thermocellum)!

E:GALDH!RecGalactose!dehydrogenase!(soil!prokaryote)!

E:GALMUT!RecGalactose!dehydrogenase!/!Galactose!mutarotase!

! ! !!


E:AGLAN!α:Galactosidase!(A.!niger)!

E:AGLANP!α:Galactosidase!(A.!niger)!powderNEW!

E:AGLGU!α:Galactosidase!(guar)!

E:BGLAN!β:Galactosidase!(A.!niger)!

E:LICACT!RecNon:specific!endo:1,3(4):β:Glucanase!(C.!thermocellum)!!E:EXBGOS!exo:1,3:β:D:Glucanase!/!β:Glucosidase!

E:LAMSE!endo:1,3:β:D:Glucanase!(Trichoderma!sp.)!

E:LAMHV!Recendo:1,3:β:D:Glucanase!(barley)!

E:EXG5AO!Recexo:1,3:β:D:Glucanse!(Aspergillus!oryzae)!

E:EXBGL!exo:1,3:β:D:Glucanase!(Trichoderma!sp.)!

E:EXBGTV!Recexo:1,3:β:D:Glucanse!(Tricoderma!virens)!

E:GAMP!RecGlucoamylase!P!(H.!resinae)NEW!

E:GLUKEC!RecGluconokinase!(E.!coli)!

E:GOXCA!Glucose!oxidase!/!Catalase!mixture!(eukaryote)!

E:GPDH5!Glucose:6:phosphate!dehydrogenase!(L.!mesenteroides)!

E:GPDHEC!RecGlucose:6:phosphate!dehydrogenase!(E.!coli)!

E:TSAGL!α:Glucosidase!(B.!stearothermophilus)!

E:TSAGS!Recα:Glucosidase!(B.!stearothermophilus)!

E:MALTS!α:Glucosidase!(maltase)!(yeast)!

E:TRNGL!α:Glucosidase!(transglucosidase)!(A.!niger)!

E:OAGUM!Oligo:α:1,6:GlucosidaseNEW!

E:BGLUC!β:Glucosidase!(A.!niger)!

E:BGOSAG!Recβ:Glucosidase!(Agrobacterium!sp.)!

E:BGOSTM!Recβ:Glucosidase!(thermostable)!(T.!maritima)!

E:BGOSPC!Recβ:Glucosidase!(thermostable)!(P.!chrysosporium)!

E:BGLAEC!Recβ:Glucuronidase!(E.!coli)!

! ! !!


E:AGUBS!Recα:Glucuronidase(Geobacillus!stearothermophilus)NEW!!

E:GOTEC!RecGlutamate!oxaloacetate!transaminase!(E.!coli)!

E:GPTBS!RecGlutamate!pyruvate!transaminase!(B.!subtilis)!

E:GLUTEC!RecGlutaminase!(E.!coli)!

E:GPO!RecGlycerol!3:phosphate!oxidase!

E:GMPK!RecGuanylate!kinase!(prokaryote)!

E:HEX10!Hexokinase!(yeast)!

E:HKGDH!Hexokinase!/!Glucose:6:phosphate!dehydrogenase!

E:HYLSP!RecHyaluronate!lyase!(novel!specificity)(soil!prokaryote)!!

E:HBDH!Rec3:Hydroxybutyrate!dehydrogenase!(prokaryote)!

E:INDHBS!Recmyo:Inositol!dehydrogenase!(B.!subtilis)!

E:ENDOIAN!endo:Inulinase!(A.!niger)!

E:EXOIAN!exo:Inulinase!(A.!niger)!

E:INVRT!Invertase!(fructofuranosidase)!(yeast)!

E:INVPD2!Invertase!(powder)!

E:INVPD5!Invertase!(powder)!

E:ISAMY!Isoamylase!(glycogen!6:glucanohydrolase)!

E:ICDHBS!RecIsocitrate!dehydrogenase!(B.!subtilis)!

E:DLDHLM!RecD:Lactate!dehydrogenase!(L.!mesenteroides)!

E:LLDHP!L:Lactate!dehydrogenase!(Porcine)NEW!

E:LICHN!Lichenase!(endo:1,3(4):β:D:glucanase)!(Bacillus!sp.)!

E:DMDHEC!RecD:Malate!dehydrogenase!(E.!coli)!

E:LMDHEC!RecL:Malate!dehydrogenase!(E.!coli)!

E:BMANN!endo:1,4:β:Mannanase!(A.!niger)!

E:BMABS!endo:1,4:β:Mannanase!(Bacillus!sp.)!

! ! !!


E:BMACJ!Recendo:1,4:β:Mannanase!(C.!japonicus)!

E:BMATM!Recendo:1,4:β:Mannanase!(T.!maritima)!

E:MNHPF!RecMannitol!dehydrogenase!(P.!fluorescens)!

E:BMOSCF!Recβ:Mannosidase!(C.!fimi)!

E:MAST!Malt!Amylase!Standard!

E:NADHPO!RecNADH!peroxidase!(E.!faecalis)!!

E:PCLYAN!Pectate!lyase!(Aspergillus!sp.)!

E:PCLYAN2!Pectate!lyase!(Aspergillus!sp.)!

E:PLYCJ!RecPectate!lyase!(C.!japonicus)!

E:PGDHEC!Rec6:Phosphogluconate!dehydrogenase!(E.!coli)!

E:PGIBS!RecPhosphoglucose!isomerase!(B.!subtilis;!regular)!

E:PGIBSB!RecPhosphoglucose!isomerase!(B.!subtilis;!large)!

E:PGIEC!RecPhosphoglucose!isomerase!(E.!coli;!regular)!

E:PGIECB!RecPhosphoglucose!isomerase!(E.!coli;!large)!

E:PGISC!RecPhosphoglucose!isomerase!(S.!cerevisiae;!regular)!

E:PGISCB!RecPhosphoglucose!isomerase!(S.!cerevisiae;!large)!

E:PGM!Recα:Phosphoglucomutase!(microbial)!

E:PMIEC!RecPhosphomannose!isomerase!(E.!coli)!

E:PTABS!RecPhosphotransacetylase!(B.!subtilis)!

E:PGALUSP!endo:Polygalacturonanase!M2!(A.!niger)!

E:BSPRPD!Protease!(subtilisin!A)!(B.!licheniformis)!

E:BSPRT!Protease!(subtilisin!A)!(B.!licheniformis)!

E:BSPRT100!Protease!(subtilisin!A)!(B.!licheniformis)!

E:PULKP!Pullulanase!M1!(K.!planticola)!

E:PULBL!Pullulanase!M2!(B.!licheniformis)!

! ! !!


E:RHAMS!Recα:Rhamnosidase!(prokaryote)!

E:SIALCP!Recexo:α:Sialidase!(C.!perfringens)!

E:SIALST!Recexo:α:Sialidase!(S.!typhimurium)!

E:SCOAS!RecSuccinyl:CoA!synthetase!(prokaryote)!

E:SUCR!Sucrase!(maltase)!(yeast)!

E:SUCRBG!Sucrase!plus!β:GalactosidaseNEW!

E:TMPK!RecThymidylate!kinase!(prokaryote)!

E:TREH!RecTrehalase!(prokaryote)!

E:UAO!RecUricase!(eukaryote)NEW!

E:XANLB!RecXanthan!lyase!(Bacillus!sp.)!

E:XYTR1!Xylanase!M1!(T.!viride)!

E:XYTR3!Xylanase!M3!(T.!longibrachiatum!;!pl!9.0)!

E:XYAN4!Xylanase!M4!(A.!niger)!

E:XYRU6!Xylanase!M6!(rumen!microorganism)!

E:XGP74!Recendo:1,4:β:Glucanase!(Paenibacillus!sp)!

E:XYLATM!Recendo:1,4:β:Xylanase!(T.!maritima)!

E:XYNACJ!Recendo:1,4:β:Xylanase!(C.!japonicus)!

E:XYNBCM!Recendo:1,4:β:Xylanase!(C.!mixtus)!

E:XYLNP!Recendo:1,4:β:Xylanase!(N.!patriciarum)!

E:XYNBS!Recendo:1,4:β:Xylanase!(B.!stearothermophilus!T6)!!

E:XYNAP!Recendo:1,4:β:Xylanase!(A.!punctata)!

E:XEGP!RecXyloglucanase!(Paenibacillus!sp.)!

E:BXSEBP!Recβ:Xylosidase!(B.!pumilus)!

E:BXSR!Recexo:1,4:β:D:Xylosidase!(S.!ruminantium;!regular)!

E:BXSRB!Recexo:1,4:β:D:Xylosidase!(S.!ruminantium;!large)!

! ! !!


Meito'Sangyo'

http://www5.mediagalaxy.co.jp/meito/kaseihin/index_e.html!!

1:22,!Nikko:cho,!Fuchu!

Tokyo,!183:0044!

Japan!

Tel:!+81!42:330:1721!

Fax:!+81!42:330:1725!

Year!Founded! 1945!!Size!($!or!employee!count!or!both)!

About!550!employees!


Small!

Enzyme!categories! Biocatalysis!!Expression!systems! Candida,rugosa,!Pseudomonas,stutzeri,,Rhizomucor,pusillus,!and!a!number!of!

other!microorganisms!Capacity/scale! Bulk.!!In:house!production!likely.!Key!People! Akihiro!Mizutani,!President!Partnerships! NA!Customers! Global!Financial!Health! +++!Catalog!of!Enzymes! ++!!Toll!Manufacturing! :!!

Meito!Sangyo!is!a!conglomerate!with!three!main!divisions:!a!real!estate!division,!a!food!ingredients!division,!and!a!fine!chemicals!division.!!The!fine!chemicals!division!manufactures!and!sells!dextran,!dextran!derivatives,!and!enzymes.!!The!enzymes!offerings!include!lipases!for!chiral!transformations,!such!as!the!lipases!from!Candida!rugosa!and!Pseudomonas!stutzeri.!Various!hydrolytic!enzymes,!chiefly!lipases,!are!available!as!dry!powder!formulations!and!as!immobilized!preparations.!The!immobilized!enzymes!are!typically!adsorbed!on!carriers!such!as!diatomaceous!earth!for!use!in!organic!solvents.!

Products:!

Lipases!from!Ps.,stutzeri,,C.,rugosa,,Rhizomucor!!

Phospholipase!D!

Immobilized!and!soluble!forms!

! ! !!


Menlo'Biotech'(Pty)'Ltd/Ecozymes'

www.menlobiotech.com!!!

98!Dover!Steet!!!

Norwich!

NR2!3LQ!!

UK!

Tel:!0835911481!

Fax:!0113163199!

Tel:!0113164063!


Year!Founded! Recent!Size!($!or!employee!count!or!both)!

Small!


Medium!

Enzyme!categories! Lipases,!proteases,!and!cellulase.!Expression!systems! NA!Capacity/scale! NA!Key!People! Robert!Gordon,!Managing!Director!(CEO)!Partnerships! South!African!branch!of!the!company!is!called!Ecozymes.!Customers! NA!Financial!Health! NA!Catalog!of!Enzymes! +!Toll!Manufacturing! :!!

Summary!povided!by!Robert!Gordon,!CEO!of!Menlo!Biotech:!“Menlo!Biotech!is!a!privately!owned!company!registered!in!South!Africa.!The!company!is!focused!on!the!manufacture!and!trading!of!chemicals,!enzymes,!microorganisms,!and!cleaning!materials.The!company!is!set!up!for!the!contract!manufacture!of!products!especially!the!blending!and!packing!of!dry!powders!and!liquids.”!

Products:!

Alkaline!Protease!

Cellulase!for!lignocellulosic!ethanol!

! ! !!


Fungal!Alpha!Amylase!

HT!Alpha!Amylase!

Lipase!

LT!Alpha!Amylase!

Neutral!Protease!

Pectinase!

!

!

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! ! !!


Merck'KGaA'(EMD'Millipore)'

www.emdgroup.com!!

Frankfurter!Strasse!250!!

64293!Darmstadt!!

Germany!

Tel:!+49!6151!72:0!!

Fax:!+49!6151!72:2000!



38,000!employees!


Small!

Enzyme!categories! Biocatalysis,!molecular!biology!!Expression!systems! Many!Capacity/scale! Grams!to!kg.!!No!in:house!production!Key!People! Karl:Ludwig!Kley,!CEO!Partnerships! Many!suppliers!Customers! Global!Financial!Health! +++!Catalog!of!Enzymes! +++!Toll!Manufacturing! :!!

Merck!is!a!pharmaceutical!company!and!has!a!division!that!sells!chemicals!and!research!tools!on!a!laboratory!scale!worldwide.!!This!catalog!business!includes!enzymes.!!!

Products:!

Amino!transferases!

Nucleic!acid!polymerses!!


Farnesyl!and!geranylgeranyltransferases!

Glycosidases!

! ! !!


Kinases!

Lipases!

Phospholipases!

Nitric!oxide!synthases!!

Nucleases!

Phosphatases!

Proteases!

Proteoglycanases!

Reductases!

!

!

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! ! !!


Metabomics'

http://www.metabomics.com!!

No.!1!Guotai!North!Rd.!

Zhangjiagang!215600!

China!

Tel:!+86:0512:56766505!


Year!Founded! Recent!Size!($!or!employee!count!or!both)!

NA!


NA!

Enzyme!categories! NA!Expression!systems! NA!Capacity/scale! Bulk.!!In:house!manufacture.!Key!People! Junhua!(Alex)!Tao,!CEO!and!Founder!Partnerships! CEO!Tao!is!also!associated!with!EnzymeWorks,!and!scale!up!of!enzyme!

production!is!probably!done!through!EnzymeWorks.!Customers! NA!Financial!Health! NA!Catalog!of!Enzymes! :!Toll!Manufacturing! +!(large!scale!fermentation!capabilities!claimed)!!

Metabomics!is!a!provider!of!contract!services!for!enzyme!discovery,!expression,!and!engineering.!The!target!applications!are!drug!discovery!and!generics,!fine!chemicals,!flavors!and!fragrances,!and!agrochemicals.!!The!company!claims!to!have!bacterial,!yeast,!insect,!and!mammalian!cell!protein!expression!capabilities.!!For!a!biocatalyst:oriented!company,!Metabomics!also!claims!to!offers!an!almost!unheard!of!breadth!of!additional!expertise!in!metabolic!pathway!identification!and!manipulation.!!!

Metabomics!advertises!the!following!capabilities:!“Identify!and!characterize!gene!clusters!and!metabolic!pathways!for!natural!product!biosynthesis;!!Combinatorial!biosynthesis!to!generate!novel!drug:like!natural!products;!!Strain!modification!to!improve!the!titer!for!production!of!xenobiotics!and!metabolites;!!Development!of!transfection!reagents!to!improve!delivery!efficiency!of!genetic!materials;!!Enzyme!discovery!and!development:!from!genes!to!proteins;!!!Screening!of!biotransformation!toolboxes;!!!!Development!of!biocatalytic!chemical!processes;!!!!Synthesis!of!complex!molecules:!chiral!compounds!and!natural!products;!!Optimization!of!fermentation!processes!Isolation!and!separation!through!nanofiltration,!ultrafiltration!and!resins.”!!' !

! ! !!


MetGen'Oy'

www.metgen.fi!!

Rakentajantie!26!

20780!Kaarina!

Finland!

Tel:!+358!2!237!7077!



12!


Large!portion!of!revenues!from!enzymes.!

Enzyme!categories! Oxidoreductases!for!lignin:degradation!applications!in!pulp!and!paper,!and!biofuels!and!biorefining!

Expression!systems! E.,coli!and!yeast!Capacity/scale! Bulk!Key!People! Alex!Michine,!CEO;!Alex!Azhayev,!CSO!Partnerships! NA!Customers! Current!pulp!and!paper!customer(s)!Financial!Health! +!(well:funded!by!venture!capital!investors)!Catalog!of!Enzymes! +!(enzymes!available,!customer!must!contact!company!for!list)!Toll!Manufacturing! :!!

MetGen!was!founded!in!2007!by!to!commercialize!engineered!oxydoreductases!enzymes!for!applications!in!pulp!and!paper,!and!biofuels!and!biorefining.!!MetGen!currently!has!12!employees!and!has!raised!a!combined!€4.7!million,!including!a!funding!round!in!December!of!2012!of!€2.7!million.!!Investors!include!Sofinnova!Partners!(Paris),!Emerald!Technology!Ventures,!Tekes,!Veraventure,!and!Cleantech!Invest.!

Products:!

Oxidoreductases!

Laccase!

!

' '

! ! !!


Millbo'

www.millbo.com!!

Via!Bellaria!s.n.!!

28069!Trecate!(NO)!

Italy!

Tel:!+39!0321795911!

Fax:!+39!0321795920!



NA!


Small!

Enzyme!categories! Baking!Expression!systems! NA!Capacity/scale! Bulk.!!No!in:house!production.!Key!People! NA!Partnerships! NA!Customers! Global!Financial!Health! NA!Catalog!of!Enzymes! ++!Toll!Manufacturing! :!!

Millbo!is!an!ingredients!supplier!for!baking!applications.!The!company!provides!a!group!of!enzymes!for!the!baking!application.!

Products:!

Amylases,!Proteases,!Lipases,!Phospholipases!

Glucose!oxidase,!Xylanase,!Hemicellulase!

!

!

' '

! ! !!


Mirpain'

www.mirpain.com!!

Birlik!San.Sit.!3.Cad!!

No:!85!Beylikduzu!!

Istanbul!!

Turkey!

Tel:!+!90!212!875!01!11!

Fax:!+90!212!875!03!06!



NA!



Enzyme!categories! Baking!Expression!systems! NA!Capacity/scale! Bulk.!!Likely!no!in:house!production!capability!Key!People! NA!Partnerships! NA!Customers! 45!countries,!global!Financial!Health! NA!Catalog!of!Enzymes! ++!Toll!Manufacturing! :!!

From!the!company!website:!“Mirpain!is!a!world!wide!known!Turkish!company!with!quality!bakery!ingredients!produced!with!latest!technology.”!

Products:!

Xylanases,!Glucose!oxidase,!Proteases,!Alpha:amylases,!Glucoamylase,!Transglutaminase,!Phospholipase,!Lipase!

!

' '

! ! !!


Mühlenchemie'

www.muehlenchemie.de!!

Kurt:Fischer:Straße!55!

22926!Ahrensburg!

Germany!!

Tel:!+49!/!(0)!41!02!/!202:001!

Fax:!+49!/!(0)!41!02!/!202:010!!




Company!type! Owned!by!parent!company!the!Stern:Wywiol!Group!Enzyme!sales!absolute!and/or!as!a!percentage!of!company!sales!

Likely!a!majority!of!revenues!from!enzyme!sales.!

Enzyme!categories! Flour!processing.!Expression!systems! NA!Capacity/scale! Bulk.!!No!in:house!production.!Key!People! Stefan!Schliesser,!Lennart!Kutschinski,!Managing!Directors!Partnerships! Multiple!distributors.!!Enzymes!made!by!other!companies!within!the!Stern:

Wywiol!Group.!Customers! Global!Financial!Health! NA!Catalog!of!Enzymes! ++!Toll!Manufacturing! :!!

From!the!company!website:!“Established!way!back!in!1923!and!a!member!of!the!Stern:Wywiol!Gruppe!since!1990,!Mühlenchemie!is!one!of!the!world's!best:known!enterprises!in!the!field!of!flour!improvement.!Mühlenchemie's!core!field!of!competence!is!developing!solutions!for!standardizing!and!optimizing!flours!:!from!classic!flour!treatment!to!concentrates!for!ready:mixed!flours.”!

Products:!

The!company!sells!about!30!formulations!of!enzymes!for!flour!treatment!including:!

Amylases!

Hemicellulases!

! ! !!


Glucoamylase!

Esterases!

Lipases!

Xylanases!

Glucose!oxidase!

Sulphhydryl!oxidase!

Proteases!

!

!

!

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MP'Biomedical'

http://www.mpbio.com/!!

29525!Fountain!Parkway!

Solon,!OH!44139!

USA!

Tel:!+1:800:854:0530!

Fax:!+1:440:337:1180!


Year!Founded! 1959!(founded!as!ICN)!Size!($!or!employee!count!or!both)!

501:1000!employees!


Relatively!small!

Enzyme!categories! Molecular!biology,!life!sciences,!industrial!biotechnologies,!diagnostics,!and!biocatalysis.!

Expression!systems! NA!Capacity/scale! Lab!scale.!!No!in:house!manufacture.!Key!People! Milan!Panic,!Founder,!Owner,!and!CEO.!Partnerships! Many!suppliers!Customers! Global!Financial!Health! +++!Catalog!of!Enzymes! +++!Toll!Manufacturing! :!!

MP!Biomedical!possesses!a!very!large!selection!of!enzymes!in!research!quantities!as!part!of!a!broader!overall!portfolio!of!products!for!life!science!and!chemical!researchers.!!!

From!the!company!website:!“MP!Biomedicals!is!dedicated!to!giving!scientists!and!researchers!innovative,!quality!tools!and!superior!service!to!aid!them!in!their!quest!for!ground:breaking!discovery!and!turning!the!hope!for!life:changing!solutions!into!a!reality.!!The!company!manufactures!and!sells!more!than!55,000!products!and!is!one!of!the!only!companies!in!the!industry!to!offer!a!comprehensive!line!of!life!science,!fine!chemical!and!diagnostic!products.!!MP!Biomedicals!is!a!world:wide!corporation,!with!ISO:certified!and!FDA:approved!manufacturing!and!distribution!facilities!throughout!the!globe!and!headquartered!in!Southern!California.!A!vast!network!of!global!distributors!and!satellite!facilities!and!offices!throughout!Europe,!Asia,!Australia!and!the!Americas!assures!customers!top!quality!products!delivered!when!and!where!needed.”!

! ! !!


Products:!!

MP!Biomedical!has!an!extensive!selection!of!more!than!500!enzyme!offerings!in!small!research!quantities.!!The!wide!range!of!enzymes!offered!covers!applications!in!molecular!biology,!life!sciences,!industrial!biotechnologies,!diagnostics,!and!biocatalysts!for!chemical!transfomations.!!!

!

!

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Nagase'ChemteX'Corp.'

http://www.nagasechemtex.co.jp/!!

1:1:17!Shinmachi!

Nishi:ku,!Osaka!550:8668!

Japan!

Tel:!+81:6:6535:2582!

Fax:!+81:6:6535:2174!



Company!type! Private,!part!of!the!Nagase!Group!Enzyme!sales!absolute!and/or!as!a!percentage!of!company!sales!

Small!portion!

Enzyme!categories! Yeast!cell!lysis,!phospholipid!modification,!starch!processing,!cosmetics,!toiletry,!brewing,!chitin!degradation,!food!processing,!and!textiles.!!!

Expression!systems! NA!Capacity/scale! Bullk.!!In:house!production!likely.!!Key!People! Kazuo!Mitsuhashi,!President!Partnerships! NA!Customers! NA!Financial!Health! NA!Catalog!of!Enzymes! ++!Toll!Manufacturing! :!!

Nagase!ChemteX!is!a!manufacturer!of!specialty!chemicals!and!materials!including!epoxy!resins,!photolithography!chemicals,!chelating!agents,!functional!monomers!and!polymers,!biocides,!and!enzymes!and!bioproducts.!!!

Products:!

Phospholipase!D!

Amylase!

Chitinase!

Protease!

Lipases!

! ! !!


Lactase!

Cellulase!

Catalase!

Ascorbate!oxidase!!

!

!

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Nanjing'Chemlin'Chemical'Industry'Co.,'Ltd'

http://chemlin.guidechem.com/!!

Rm.902!Longyin!Plaza!

No.!217!Zhongshan!Rd.(N)!Nanjing!210009!

China!

Tel:!+86:25:83697070!

Fax:!+86:25:83453275!


101:500!employees!


Small!

Enzyme!categories! Biocatalysis,!carbohydrate!degradation!Expression!systems! NA!Capacity/scale! Small!scale.!!In:house!production!unlikely.!Key!People! NA!Partnerships! NA!Customers! NA!Financial!Health! NA!Catalog!of!Enzymes! +!(small!selection)!Toll!Manufacturing! :!!

Nanjing!Chemlin!Chemical!Industry!Co.,!Ltd.!is!a!supplier!of!fine!chemicals!and!laboratory!chemicals.!

Products:!

Lipases!(2)!

Cellulase!

!

!

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New'England'Biolabs'

www.neb.com!!

240!County!Road!

Ipswich,!MA!01938:2723!

USA!

Tel:!+1:978:927:5054!

Fax:!+1:978:921:1350!!



>400!employees!


Significant!contributor!to!revenues!

Enzyme!categories! Molecular!biology.!Expression!systems! Many!Capacity/scale! Bulk.!!In:house!production.!Key!People! James!Ellard,!CEO!Partnerships! Distributors!world:wide!Customers! Global!Financial!Health! +++!Catalog!of!Enzymes! +++!(276!restriction!enzymes)!Toll!Manufacturing! +!!

New!England!Biolabs!(NEB)!is!one!of!the!leading!companies!in!supplying!enzymes!in!molecular!biology.!!Its!selection!of!DNA!and!RNA!enzymes!is!large!and!its!reputation!is!excellent.!

Products:!


Polymerases!

Ligases!

Phosphatases!

Kinases!

! ! !!


Nucleases!

Methyltransferases!

Sulfurylase!

Apyrase!

Recombinase!

Beta:agarase!I!

Pyrophosphatases!

!

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Nordmann,'Rassmann'

www.nordmann:rassmann.com!!

!Kajen!2!

20459!Hamburg!

Germany!

Tel:!+49!(40)!36!87:0!

Tel:!+49!(40)!36!87!249!



280!employees!


Small!

Enzyme!categories! Bakery,!dairy.!Expression!systems! NA!Capacity/scale! Bulk.!No!in:house!production.!Key!People! Edgar!E.!Nordmann,!Gabriele!Henke,!Carsten!Güntner,!Managers!Partnerships! NA!Customers! Global!Financial!Health! NA!Catalog!of!Enzymes! +!Toll!Manufacturing! :!!

From!the!website:!“Established!in!1912!by!Eduard!Nordmann!and!Fritz!Rassmann!as!a!company!trading!in!natural!rubber,!Nordmann,!Rassmann!today!is!an!international!group!undertaking!with!a!shared!focus!on!the!distribution!of!chemical!and!natural!raw!materials!as!well!as!specialty!chemicals.!With!our!group!headquarters!situated!in!the!heart!of!Hamburg!and!eleven!subsidiaries!banded!throughout!Europe,!our!distribution!and!sales!forces!serve!as!important!links!that!join!suppliers!from!around!the!globe!to!customers!from!the!wider!manufacturing!industry.”!

Products:!

Two!bakery!and!dairy!enzymes:!!Undisclosed,!but!likely!to!be!xylanase!and!protease.!

!

!

! ! !!


Novozymes'

http://www.novozymes.com/!!

Krogshoejvej!36!

2880!Bagsvaerd!

Denmark!

Tel:!+45!4446!0000!!

Fax:!+45!4446!9999!


6,000!employees!

Company!type! Public:!NZYM,!voting!control!from!parent!company!Novo!Enzyme!sales!absolute!and/or!as!a!percentage!of!company!sales!

Nearly!all!revenues!are!from!enzyme!sales!and!technological!assistance!related!to!using!the!enzymes.!

Enzyme!categories! Industrial!enzyme!applications.!!Novozymes!has!around!700!products!in!the!categories!of!agriculture,!bioenergy,!biopharma,!food!and!beverages,!household!care,!leather,!pulp!and!paper,!textile,!and!wastewater!solutions.!

Expression!systems! Many!Capacity/scale! World:leader!Key!People! Peder!Holk!Nielsen,!CEO!Partnerships! Distributes!through!hundreds!of!regional!and!specialty!companies.!Customers! Global!Financial!Health! +++!(strong!profits!and!growth)!Catalog!of!Enzymes! +++!(extensive,!not!retail!friendly)!Toll!Manufacturing! :!!

Novozymes!is!the!premier!manufacturer!of!enzymes!worldwide.!!It!has!market:leading!positions!in!most!of!the!enzyme!classes!in!which!it!operates.!!The!company!has!manufacturing!and!operational!expertise,!and!spends!14%!of!revenues!on!R+D!to!continually!improve!its!products.!!Novozymes!also!brings!in!products!and!expertise!through!acquisitions!of!other!companies.!!Currently,!the!company’s!cellulosic!ethanol!enzyme!technology!is!gaining!adoption.!!Novozymes!sells!in!large!quantities,!and!it!is!often!easier!for!most!customers!to!purchase!Novozymes’!products!via!distributors.!!Relevant!distributors!are!listed!throughout!this!compilation!of!companies.!!!

Extensive!product!line!covering!all!aras!of!industrial!enyzmes.!

!

! !

! ! !!


Novus'International,'Inc.'

http://www.novusint.com!!

20!Research!Park!Drive!!

St.!Charles,!MO!63304!

USA!

Tel:!+1:314:576:8886!

Tel:!+1:888:906:6887!

Fax:!+1:314:576:2148!



501:1000!employees!


Small!

Enzyme!categories! Animal!feed!Expression!systems! Probably!strain!of!Aspergillus,niger!!Capacity/scale! Bulk.!!In:house!production!unlikely.!Key!People! NA!Partnerships! NA!Customers! Global.!Financial!Health! +++!Catalog!of!Enzymes! +!Toll!Manufacturing! :!!

Novus!is!a!manufacturer!and!supplier!of!animal!feed!and!additives.!

Products:!

Two!animal!feed!enzyme!products:!Cibenza!and!Idea.!!“CIBENZA®!CSM!feed!additive!is!an!enzymes!blend!containing!xylanase,!alpha:galactosidase!and!beta:glucanase!activities!that!optimize!energy!utilization,!improve!productivity!and!reduce!feed!cost.”!

!

' '

! ! !!


Nutreco'

http://www.nutreco.com!!!

Prins!Frederiklaan!4!

AMERSFOORT,!3818!KC!

Netherlands!

Tel:!+31:33:4226100!

Fax:!+31:33:4226101!


10,000!employees!

Company!type! Public:!NUO!Enzyme!sales!absolute!and/or!as!a!percentage!of!company!sales!

Small!

Enzyme!categories! Animal!feed!Expression!systems! NA!Capacity/scale! Bulk.!!In:house!production!unlikely.!Key!People! Knut!Nesse,!CEO.!Partnerships! NA!Customers! Global.!Financial!Health! +++!Catalog!of!Enzymes! +!Toll!Manufacturing! :!!

Nutreco!is!an!animal!and!fish!nutrition!company.!

Product:!

Phytase!

!

!

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! ! !!


Nzomics'Biocatalysis'

http://www.nzomics.com/!!

Ellison!Building!

Newcastle!upon!Tyne!

NE1!8ST!

UK!!

Tel:!+44!191!227!3550!

Fax:!+44!191!227!3519!!



1:10!employees!

Company!type! Private,!closely!associated!with!Northumbria!University!in!Newcastle,!England!


Minority!revenue!stream.!

Enzyme!categories! Biocatalysis!Expression!systems! E.,coli,Capacity/scale! Small!Key!People! Prof.!Gary!Black,!Technical!Director;!Justin!Perry,!Commercial!Director!!Partnerships! NA!Customers! Major!drug!firms!and!contract!manufacturers!Financial!Health! NA!Catalog!of!Enzymes! +!Toll!Manufacturing! +!(small!scale)!!

From!the!company!web!site:!“Nzomics!Biocatalysis!offers!products,!services!and!expertise!to!those!companies!looking!to!use!biocatalysis!in!a!post:genomic!era.!This!presents!opportunities!for!R&D!teams!to!exploit!state!of!the!art!advances!in!enzyme!production!and!optimization.”!

From!an!article!in!Chemical!and!Engineering!News:!“Based!at!Northumbria!University!in!Newcastle,!England,!Nzomics!Biocatalysis!!was!founded!in!2006!by!a!chemist!and!a!biologist.!The!partners!thought!they!would!sell!enzymes!such!as!nitrile!hydratases!that!were!useful!but!not!widely!available,!but!they!have!shifted!to!offering!consulting!and!services!in!the!areas!of!custom!enzymes!and!libraries.”!

!

! ! !!


Products:!

Nitrile!hydratases!(9!enzymes,!individualy!or!in!kit!format)!

Pectate!lyases!(3!enzymes,!individualy!or!in!kit!format)!

Hyaluronase!!

Carboxyesterase!

Lipase!

!

!

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NZYTech,'Lda.'

www.nzytech.com!!

Estrada!do!Paço!do!Lumiar!

Campus!do!Lumiar,!Edifício!E!:!R/C!

1649:038!Lisboa!

Portugal!

Tel:!+351.213643514!!

Fax:!+351!217151168!!



11:50!employees!



Enzyme!categories! Molecular!biology,!carbohydrate!degradation,!diagnostics.!Expression!systems! Many!Capacity/scale! Lab!scale!Key!People! Carlos!Fontes,!Managing!Director!Partnerships! Prozomix!sells!NZYTech’s!polymerase!Customers! Global,!distributors!in!multiple!countries!and!continents!Financial!Health! NA!Catalog!of!Enzymes! +++!Toll!Manufacturing! :!!

NZYTech!offers!a!full!suite!of!molecular!biology!tools!including!DNA!reagents!and!consumables.!!The!company!offers!molecular!biology!enzymes,!but!also!offers!enzymes!for!carbohydrate!hydrolysis!and!for!analytical!and!diagnostic!applications.!!!!!

From!the!company!website:!“NZYTech!was!founded!in!June!2008!by!Professors!Carlos!Fontes!and!Luís!Ferreira!in!order!to!explore!the!commercial!potential!of!the!carbohydrate:active!enzymes!characterized!at!their!University!Laboratories!at!the!Faculty!of!Veterinary!Medicine!in!Lisbon.!NZYTech!aims!to!build!a!reputation!in!the!fields!of!Molecular!Biology,!Carbohydrate!Research!and!Biochemical!and!Food!Analysis!through!a!continuous!investment!in!research!and!innovation.”!

!

! ! !!


Products:!

RNase!

Polymerases!

Reverse!transcriptase!

Ligase!

Phosphatase!




!

!

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OenoBioTech'SAS'

http://www.oenobiotech.com/!!

Paris!:!Ile!de!France!

30!rue!des!Terres!Fortes!

77600!Chanteloup!en!Brie!

France!

Tel:!+33!1!64027550!

Fax:!+33!1!64027245!



NA!


Likely!significant!portion.!

Enzyme!categories! Winemaking!!Expression!systems! NA!Capacity/scale! Bulk.!!No!in:house!production.!Key!People! NA!Partnerships! Verenium!supplies!the!enzymes!that!the!company!sells!Customers! NA!Financial!Health! NA!Catalog!of!Enzymes! +!(small!assortment)!Toll!Manufacturing! :!!

OenoBioTech!is!the!sister!company!of!WeissBiotech.!!It!was!set!up!to!distribute!enzymes!from!Verenium,!and!materials!from!other!sources!like!yeasts!and!tannins,!to!the!wine!industry!in!Europe.!!It!makes!no!products!of!its!own.!!

Products:!

Pectinases!

Lysozyme!

Hemicelluase!

Beta:glucosidase' !

! ! !!


Oenobrands'SAS'

http://www.oenobrands.com!!

Parc!Scientifique!Agropolis!II,!bat!5!

2196!Blvd!de!La!Lironde.!CS!34603!

34397!Montpellier!Cedex!5!

France!



11:50!employees!

Company!type! Joint!venture!between!DSM!and!AnchorBioTechnologies!Enzyme!sales!absolute!and/or!as!a!percentage!of!company!sales!


Enzyme!categories! Winemaking!!Expression!systems! NA!Capacity/scale! Bulk.!!No!in:house!production.!Key!People! NA!Partnerships! DSM(The!Netherlands)!and!AnchorBioTechnologies!(South!Africa)!Customers! OenoBrands!operates!in!over!40!countries!through!its!global!distribution!

network.!Financial!Health! NA!Catalog!of!Enzymes! ++!Toll!Manufacturing! :!!

Oenobrands!is!a!leading!supplier!of!ingredients!for!the!wine!industry.!Developed!by!winemaking!experts!in!close!contact!with!universities!and!institutes,!the!company!supplies!a!complete!range!of!wine!biotechnology!ingredients!for!specific!applications.!Whether!producing!bulk!or!super!premium!wines,!Oenobrands!enzymes,!wine!yeasts!and!fermentation!aids!provide!solutions!tailored!to!any!winemaking!style.!

Products:!

Pectinases,!Lysozyme,!Beta:glucanase,!Beta:glycosidases,!Alpha:glycosidases!

!

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OptiGene'

www.optigene.co.uk!!

Unit!5!Blatchford!Road!!

Horsham!West!Sussex!RH13!5QR!

UK!

Tel:!+44(0)1403!274980!!

Fax:!+44(0)1403!271017!



NA!


Small!

Enzyme!categories! Molecular!biology!Expression!systems! NA!Capacity/scale! Laboratory!scale!Key!People! NA!Partnerships! Distributors!globally!Customers! Global!Financial!Health! NA!Catalog!of!Enzymes! +!Toll!Manufacturing! :!!

From!the!company!website:!“OptiGene!Limited!was!formed!in!2008!to!develop!and!deliver!advanced!molecular!diagnostics!solutions!for!applications!across!a!range!of!market!sectors.!!OptiGene!was!established!with!the!primary!goal!of!providing!the!highest!quality!instrumentation!and!performance:leading!reagents!to!support!isothermal!amplification!of!DNA!and!RNA.”!

Products:!

DNA!polymerases!

' '

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ORBA'

www.orba.com.tr!!

Biokimya!San.!ve!Tic.!A.Ş.!

Okul!Cad.!26!Orhanlı!Tuzla!!

34956!Istanbul!

Turkey!

Tel:!+90!216!394!30!49!!

Fax:!+90!216!394!30!51!!


11:50!employees!



Enzyme!categories! Baking,!brewing,!animal!nutrition!Expression!systems! A.,oryzae,!others!undisclosed!Capacity/scale! Bulk.!!In:house!production.!Key!People! NA!Partnerships! NA!Customers! NA!Financial!Health! NA!Catalog!of!Enzymes! ++!Toll!Manufacturing! :!!

From!the!company!website:!“ORBA!is!an!enzyme!producer!with!an!emphasis!on!offering!you!tailored!solutions!to!suit!your!production!process.!We!started!in!1977!by!producing!our!first!line!of!alpha:amylase!products!for!the!baking!industry!to!prolong!bread!shelf:life.!Today!we!offer!our!products!and!services!in!baking,!brewing,!distilling,!animal!nutrition,!starch!and!industrial!applications.”!!!

Products:!

Beta:glucanase!

Xylanase!

Phytase!

Proteases!

! ! !!


Papain!

Amylases!

Hemicellulases!

Glucose!oxidase!

Lipase!

Arabinoxylanase!

!

!

!

!

!

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Oriental'Yeast'Company'

http://www.oyc.co.jp/!!!

3:6:10!Azusawa,Itabashi:ku!

Tokyo!174:8505!

Japan!

Tel:!+81:3:3968:1192!

Fax:!+81:3:3968:4863!!



610!employees!

Company!type! Owned!by!Nisshin!Seifun!Group!Enzyme!sales!absolute!and/or!as!a!percentage!of!company!sales!


Enzyme!categories! Biocatalysis,!diagnostics.!!!Expression!systems! Many!proprietary!strains.!Capacity/scale! Bulk.!!In:house!production!Key!People! Masashi!Nakagawa,!President;!Takao!Watanabe,!Managing!Director!Partnerships! NA!Customers! Global!Financial!Health! +++!(long!profitable!history)!Catalog!of!Enzymes! +++!(large!selection)!Toll!Manufacturing! +++!!

Oriental!Yeast!Co.,!Ltd.!was!founded!to!provide!pure:culture!bread!yeast,!and!has!grown!into!a!company!leveraging!its!fermentation!and!other!capabilities!into!a!wide!range!of!markets.!!Still!a!leader!in!food,!OYC!offers!a!large!selection!of!enzymes!for!many!applications,!especially!for!baking!but!also!many!enzymes!for!biocatalysis!and!diagnostics.!!The!company!has!offices!in!Europe,!China,!and!the!United!States,!and!sells!globally.!!OYC!has!branched!out!into!many!different!areas!including!animal!feed!ingredients,!food!ingredients,!laboratory!animals,!antibodies,!testing!and!diagnostics,!and!life!science!products,!and!enzymes!make!up!just!a!portion!of!revenues.!!!

Products:!

Many.!!A!selection!includes:!

Aconitase!(Pig!heart)!

! ! !!


Alcohol!dehydrogenase!(Yeast)!

rhALT!(Human!liver)!

ASOD!(Cucumber)!

CE(PP)!(Porcine!pancreas)!

CK!(Rabbit!muscle)!

rCO!(Nocardia!sp.)!

CPase!Y!(Yeast)!

Diaphorase!(Clostridium!kluyveri)!

Enolase!(Yeast)!

Glucoamylase!(Rhizopus!sp.)!

rβ:Glucuronidase!(Bacteria)!

α:GDH!(Rabbit!muscle)!

GlDH(NADP)!(Yeast)!

GlDH!(Beef!liver)!

rGlDH(NADP)!(Bacteria)!

α:Glucosidase!(Yeast)!

β:Glucosidase!(Almond)!

GOD!(Microorganism)!

G:6:PDH!(Yeast)!

G:6:PDH!(Leuconostoc!mesenteroides)!

rG:6:PDH!(Leuconostoc!mesenteroides)!

Glutathione!reductase!(Yeast)!

γ:GT!(Beef!kidney)!

rhCK:MB!

rhCK:MM!

! ! !!


Hexokinase!(Kluyveromyces!fragilis)!

Hexokinase!(GRADE:S)!(Yeast)!

Hexokinase!(GRADE:I)!(Yeast)!

r3α:HSDH!(Bacteria)!

Isocitrate!dehydrogenase(NAD)!(Bacteria)!

Isocitrate!dehydrogenase!(NADP)!(Yeast)!

Isocitrate!dehydrogenase!(Taq)!(Bacteria)!

Lactate!dehydrogenase!(Pig!heart)!

Lactate!dehydrogenase!(Bacteria)!

Lactate!dehydrogenase!(Leuconostoc!mesenteroides)!

Lactate!dehydrogenase!(Rabbit!muscle),!

Lactate!dehydrogenase!(Chicken!heart)!

Malate!dehydrogenase!(Yeast)!

Malate!dehydrogenase!(Pig!heart)!

rMalate!dehydrogenase!(Bacteria)!

Myokinase!(Yeast)!

Maltose!phosphorylase!(Bacteria)!

Mutarotase!(Pig!kidney)!

rNTR!(Yeast)!

rProtocatechuate!3,4:dioxygenase!(Bacteria)!

6:PGDH!(Leuconostoc!mesenteroides)!

Phosphoglucomutase!(Rabbit!muscle)!

rp:hydroxybenzoate!hydroxylase!(Bacteria)!

Pyruvate!kinase!(R.M.)!(Rabbit!muscle)!

Peroxidase!(Horseradish!roots)!

! ! !!


PTA!(Leuconostoc!mesenteroides)!

Sucrose!phosphorylase!(Leuconostoc!mesenteroides)!

rUrease!(Bacteria)!

Uricase!(Yeast)!

Xanthine!oxidase!(Butter!milk)!

!

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! ! !!


Parchem'

www.parchem.com!!

415!Huguenot!Street!

New!Rochelle,!New!York!10801!

USA!

Fax:!+1:914:654:6800!

Fax:!+1:914:654:6899!



16:30!employees!


Small!

Enzyme!categories! No!specific!markets!targeted;!enzymes!applicable!to!a!broad!range!of!applications!including!baking,!dairy,!animal!nutrition,!filtration!aids,!etc.!

Expression!systems! None.!Capacity/scale! Bulk.!!No!in:house!production.!Key!People! Ephraim!Rabin,!CEO!Partnerships! Works!with!many!suppliers.!Customers! Mostly!USA!based.!Financial!Health! NA!Catalog!of!Enzymes! ++!Toll!Manufacturing! :!!

Parchem!is!an!importer!and!distributor!of!a!large!range!of!specialty!chemicals!

Products:!

38!different!enzyme!products!including:!

Peptidase!

Phytase!

Phospholipase!

Pullulanase!

! ! !!


Xylanase!

Papain!

Proteases!

Lysozyme!

Lipases!

Glucose!oxidase!

Invertase!

Hemicellulase!

Cellulases!

Amylases!

Catalase!

Bromelain!

Beta:glucanase!

Galactosidase!

Amyloglucosidase!

Lactase!

!

!

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! ! !!


PROCHIMICA'NOVARESE'S.p.A.'

http://www.prochimicagroup.com/!!

Via!Marconi!21!!

28060!S.!Pietro!Mosezzo!(NO)!!

Italy!

Tel:!+39!0321!485511!!

Fax:!+39!0321!468704!!



NA!


Small!

Enzyme!categories! Textiles!!!Expression!systems! NA!Capacity/scale! Bulk.!!No!in:house!production.!Key!People! NA!Partnerships! NA!Customers! NA!Financial!Health! !

+++!Catalog!of!Enzymes! +!Toll!Manufacturing! :!!

Prochimica!is!a!conglomerate!of!specialty!chemical!makers!and!suppliers.!!One!of!its!main!markets!is!the!textile!industry,!to!which!it!supplies!auxiliaries,!dyestuffs,!pigments,!and!enzymes.!

Products:!

Alpha:amylase!

Cellulase!

Laccase!

!

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! ! !!


Proenzimas'Ltda.'

http://www.proenzimas.com/!!

Calle!56!Numero!5!N:65!

Bodega!4,!La!Flora!Industrial!

Cali!

Columbia!

Tel:!4476028!

Fax:!4466442! !


Year!Founded! At!least!22!years!old!Size!($!or!employee!count!or!both)!

NA!


Large!portion!of!total!revenues!

Enzyme!categories! Animal!nutrition,!baking,!dairy,!brewing,!food!and!beverage,!starch!processing.!!!

Expression!systems! None!Capacity/scale! Bulk.!!No!in:house!production.!Key!People! NA!Partnerships! NA!Customers! NA!Financial!Health! NA!Catalog!of!Enzymes! +++!Toll!Manufacturing! :!!

Proenzimas!is!an!importer,!developer,!and!supplier!of!enzymes.!!It!has!a!larger!catalog!of!available!enzymes!for!use!in!many!industries.!!!

Products:!

Lactases!

Xylanases!

Alpha:amylases!

Proteases!

! ! !!


Lipases!

Transglutamases!

Papain!

Pectinase!

Glucose!oxidase!

Glucoamylase!

Invertase!

Dextranase!

!

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! ! !!


Promega'Corp.'

http://www.promega.com/!!

2800!Woods!Hollow!Rd!

Madison!WI!53711:5399!

USA!

Tel:!+1:608:274:4330!!


About!1,200!employees!


Small!

Enzyme!categories! Molecular!biology!and!life!sciences.!Expression!systems! NA!Capacity/scale! Lab!scale.!!In:house!production.!Key!People! William!A.!Linton,!Chairman!and!CEO!and!Founder!Partnerships! NA!Customers! Promega!has!branches!in!15!countries!and!more!than!50!global!distributors!

serving!100!countries.!Financial!Health! +++!Catalog!of!Enzymes! ++!Toll!Manufacturing! +!!

From!the!company!website:!“With!a!portfolio!of!more!than!2,500!products!covering!the!fields!of!genomics,!protein!analysis!and!expression,!cellular!analysis,!drug!discovery!and!genetic!identity,!Promega!is!a!global!leader!in!providing!innovative!solutions!and!technical!support!to!life!scientists!in!academic,!industrial!and!government!settings.”!

Products:!


DNA!Polymerases!

Glycosidases!

Proteases!

Luciferase' !

! ! !!


Protean's.r.o.'

http://protean.cz/!!

Pod!Lesem!9!

373!16!Dobrá!Voda!u!Českých!Budějovic!

Czech!Republic!

Tel:!+420!380!120!427!

Tel:!+420!724!731!832!



1:10!employees!


NA!

Enzyme!categories! NA!Expression!systems! NA!Capacity/scale! Up!to!gram!quantities!of!recombinant!proteins!Key!People! Ladislav!Burýšek,!Research!&!Development!Director!Partnerships! NA!Customers! NA!Financial!Health! NA!Catalog!of!Enzymes! :!Toll!Manufacturing! +!(small!scale)!!

Protean!is!a!small!company!that!does!R+D!in!diagnostics!and!offers!some!diagnostics!kits!and!materials!for!sale.!!The!company!also!does!recombinant!protein!expression!on!a!contract!basis,!on!a!small!scale.!

!

!

!

' '

! ! !!


ProteoGen'Bio'S.r.l.''

http://www.proteogenbio.com!!

Viale!Rinaldo!Piaggio!32!Pontedera!

PISA!56025!!

Italy!

Tel:!+39!0587!274816!

Tel:!+39!0587!970085!



1:10!employees!


NA!

Enzyme!categories! Life!science.!Expression!systems! NA!Capacity/scale! Small!Key!People! Massimiliano!Salerno,!President!and!CEO;!Roberto!Marangoni,!Advisor!from!

whose!academic!lab!the!company’s!technology!originated!Partnerships! Partnered!with!Singredia!Life!Science!to!develop!and!manage!Proteogen!

Bio’s!international!commercial!strategy!Customers! Merck!Serono,!Genentech,!Pfizer,!Amgen,!Thermo!Scientific,!

GlaxoSmithKline,!Teva!Financial!Health! NA!Catalog!of!Enzymes! +!Toll!Manufacturing! :!!

From!the!company!website:!“ProteoGen!Bio!(PGB)!is!a!start:up!biotech!company,!possessing!an!innovative!proprietary!technique!for!enzyme!immobilization!with!great!efficiency.!This!allows!us!to!produce!the!DigesTip,!a!pipette:tip!device!for!the!one:minute!digestion!of!protein!for!sample!preparation,!with!results!comparable!to!the!traditional!overnight!technique,!with!numerous!applications!in!Proteomics,!Genomics,!and!Diagnostics.”!

Products:!

Immobilized!proteases!on!pipette!tips!

' '

! ! !!


Prozomix'Limited'

http://www.prozomix.com/!!

Station!Court!

Haltwhistle!

Northumberland!

NE49!9HN!!!

UK!

Tel:!+44!(0)!1434!400455!

Fax:!+44!(0)!1434!322822!



1:10!employees!


Revenues!from!enzyme!sales,!contract!R+D,!and!from!the!Kyrobio!European!grant.!

Enzyme!categories! Biocatalysis!Expression!systems! NA!Capacity/scale! Small!Key!People! Simon!Charnock,!Managing!Director!(CEO)!Partnerships! Sells!enzymes!manufactured!by!SinoBios.!!Partnered!with!CLEA!Technologies!

for!immobilized!nitrile!hydratases.!Customers! NA!Financial!Health! :!Catalog!of!Enzymes! ++!Toll!Manufacturing! +!!

From!the!LinkedIn!entry!of!the!CEO:!“Prozomix!Limited!is!a!privately!owned!UK!biotechnology!company!that!develops,!produces!and!supplies!a!large,!diverse!and!rapidly!expanding!range!of!highly!purified!recombinant!enzymes!and!proteins!of!known!sequence!with!associated!biochemical!reagents,!kits!and!services!for!the!pure!and!applied!researcher.!!Our!drive!for!product!growth!respects!the!"Academiome"!(i.e.!the!global!academic!resource)!as!evidenced!by!our!Commercial!Academic!Partner!(CAP)!Programme,!that!enables!rapid!and!efficient!commercialisation!of!enzyme!/!protein!encoding!plasmids,!in!exchange!for!a!generous!royalty!of!17.5!%.”!

!

! ! !!


Products:!

Sells!kits!and!individual!enzymes!in!the!following!categories:!!

Sterol!glycosyltransferases!(4!enzymes)!

Transaminases!(200!enzymes)!

Nitrile!hydratases!both!soluble!and!immobilized!(18!enzymes!each!kit)!

Keto!reductases!(96!enzymes)!

Glycoside!hydrolases!(71!enzymes)!

Ene!reductases!(200!enzymes)!

Cytochrome!P450s!(10!enyzmes)!

Alcohol!dehydrogenases!(200!enzymes)!

!

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! ! !!


Prozyme'

http://www.prozyme.com!!

3832!Bay$Center$Pl!!

Hayward,!CA!94545!

USA!

Tel:!+1:800:457:9444!

Tel:!+1:510:638:6900!

Fax:!+1:510:638:6919!!

Fax:!+1:!510:300:3460!



NA!



Enzyme!categories! Life!science/diagnostics:!glycobiology.!Expression!systems! NA!Capacity/scale! Lab!scale!Key!People! NA!Partnerships! NA!Customers! NA!Financial!Health! NA!Catalog!of!Enzymes! ++!!Toll!Manufacturing! NA!!

From!the!company!website:!“ProZyme,!Inc.,!established!in!1990,!specializes!in!the!development!of!value:added!reagents,!kits!and!platforms!for!improved!analytical!results.!Technologies!used!includes:!microbial!fermentation!sciences;!large:scale!native!and!recombinant!purification!and!formulation;!assay!development!and!analytical!services!for!our!customers.!Analytical!methods!employed!include!HPLC,!CE,!bead:based!immunassays!and!ELISAs.!!Most!recently!ProZyme!has!commercialized!the!GlykoPrep™!Sample!Preparation!Platform!to!significantly!speed!and!simplify!sample!preparation!for!glycoanalysis,!yielding!high:quality!results!to!support!all!stages!of!biopharmaceutical!drug!development!and!manufacture.”!

! ! !!


Products:!

Endoglycosidases!(PNGaseF,!Endo:H,!Endo!F2,!PNGaseA,!O:glycanase)!

Exoglycosidases!(sialidase,!alpha:galactosidase,!beta:galactosidase,!hexosaminidase,!galactosaminidase,!alpha:mannosidase,!beta:mannosidase,!alpha:fucosidase)!

!

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! ! !!


Purolite'

www.purolite.com!!

150!Monument!Road!

Bala!Cynwyd,!PA!19004!

USA!

Tel:!+1!610!668!9090!

Fax:!+1!610!668!8139!

!Email:[email protected]!!

Research!Site!in!the!UK!

Llantrisant!Business!Park!

Llantrisant,!Wales!CF72!8LF!

United!Kingdom!

Tel:!+44:1443:222336!


500+!employees!


None!

Enzyme!categories! Enzyme!immobilization!Expression!systems! NA!Capacity/scale! Bulk!Key!People! Allessandra!Basso,!PhD,!Lifetech!manager;!Erik!de!Vries,!PhD,!Technical!Sales!

Manager,!LIfetech!for!the!Americas!Partnerships! Partnership!with!Codexis!for!the!immobilization!of!enzymes!Customers! Global!Financial!Health! NA!Catalog!of!Enzymes! :!Toll!Manufacturing! :!!

From!the!company!website:!“Purolite!was!founded!in!1981!and!is!a!leading!manufacturer!of!ion!exchange,!catalyst,!adsorbent!and!specialty!resins.!They!have!developed!the!widest!platform!of!resins!for!enzyme!immobilization!as!part!of!the!LifeTech!product!portfolio.!Headquartered!in!Bala!Cynwyd,!Pa.,!

! ! !!


the!company!has!ISO:certified!manufacturing!facilities!in!the!USA,!China,!and!Romania!and!operates!dedicated!R&D!centers!in!the!USA,!China,!Romania,!Russia,!and!the!UK.!Purolite,!the!only!company!focused!exclusively!on!the!ion!exchange!market,!has!40!sales!offices!in!more!than!30!countries.”!

Products:!

Purolite!sells!resins!for!enzyme!immobilization.!

About!the!immobilization!carriers!from!the!company!website:!“Purolite®!ECR!enzyme!carriers!are!methacrylic!or!styrenic!polymers!with!various!functional!groups!on!the!matrix.!These!enzyme!carriers!are!made!in!150!:!300!and!300!:!700!micron!mean!particle!size!range.!For!food!applications,!they!are!also!available!in!300:!1200!micron.”!

!

!

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! ! !!


Research'Products'Company'

http://researchprod.com/!!

P.O.!Box!1460!

Salina,!KS!67402!

USA!

Tel:!+1:785:825:2181!or!+1:800:234:7174!

Fax:!+1:785:825:8908!



NA!


Small!

Enzyme!categories! Baking.!Expression!systems! NA!Capacity/scale! Bulk.!!No!in:house!production.!Key!People! Monte!White,!President!Partnerships! NA!Customers! NA!Financial!Health! NA!Catalog!of!Enzymes! +!!Toll!Manufacturing! :!!

From!the!company!website:!“Since!1946,!Research!Products!Company!has!provided!the!milling!and!baking!industries!with!innovative!ideas,!services!and!products!second!to!none.!We’ve!supplied!the!industry!with!standard:setting!flour!oxidation!and!maturing!services,!mineral!premixes,!micro:ingredient!dispensing!systems,!and!on:site!field!servicing.”!

Product:!!

Fungal!alpha:amylase!enzyme!premix!derived!from!Asperigillus,oryzae!

!

!

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! ! !!


Roal'Oy'

http://www.roal.fi/!!!!

Tykkimäentie!15!

05200!Rajamäki!

Finland!

Tel:!+358!9!290!420!



129!employees!

Company!type! Jointly!owned!by!Associated!British!Foods!plc!and!Altia!Oy!(alcohol!beverage!company)!


€47!million!annual!(2011:2012)!

Enzyme!categories! A!large!selection!in!textiles,!paper!and!pulp,!detergent!enzymes,!baking,!food,!animal!feed,!brewing!and!winemaking!

Expression!systems! Trichoderma,,Aspergillus,,Bacillus!Capacity/scale! Multi:ton!Key!People! Pekka!Kekki,!Managing!Director!Partnerships! Joint!owner!AB!Enzymes!is!the!sole!distributer!for!Roal!Customers! AB!Enzyme!Financial!Health! ++!(appears!to!be!a!profitable!company)!Catalog!of!Enzymes! :!(Roal’s!enzymes!are!distributed!through!AB!Enzymes)!Toll!Manufacturing! :!(Joint!owner!AB!Enzyme!works!with!customers!to!provide!R+D!for!custom!

projects,!and!these!projects!are!likely!at!least!in!part!handed!off!to!Roal)!!

Roal!Oy!is!one!of!the!larger!producers!of!enzymes,!and!exports!about!90%!of!its!products!outside!of!its!home!country!of!Finland.!!The!company!was!founded!in!1991!as!a!joint!venture!between!Alkon!of!Finland!and!Röhm!of!Germany,!and!is!now!owned!by!Altia!of!Finland!and!Associated!British!Foods!of!the!United!Kingdom.!!In!2009,!the!company!expanded!its!production!facilities!by!about!40%.!!About!10%!of!

Notable!Facts:!Roal!Oy!scientists!publish!frequently.!!A!list!of!their!publications!can!be!found!on!their!website.!!Recent!publications!have!focused!on!cellulases!and!biomass!degradation.!

Products:!

See!AB!Enzyme!and!AB!Vista!entries!for!products!offerings.!

' '

! ! !!


RobinsonBioproducts'

www.robinsonbioproducts.com!!

PO!Box!1666!

#101!–!45!North!Railway!St.!

Okotoks,!Alberta,!T1S1B5!

Canada!!

Tel:!+1:403:938:0556!

Tel:!+1:888:968:0556!

Fax:!+1:403:938:0022!



Small!


Small!

Enzyme!categories! Animal!feed!Expression!systems! NA!Capacity/scale! Bulk.!!No!in:house!production.!Key!People! Daryl!Robinson,!President!Partnerships! Enzymes!are!sourced!from!AB!Vista!Customers! Canada!Financial!Health! NA!Catalog!of!Enzymes! ++!Toll!Manufacturing! :!!

From!the!website:!“Robinson!Bioproducts!Inc.!is!a!Canadian!Distributor!to!the!animal!feed!industry.!!We!have!partnered!with!the!leaders!in!the!industry!to!supply!Canada’s!animal!feed!industry!with!the!very!best!ingredients!and!animal!health!products.”!

Products:!

Phytase!

Xylanase!

!

! ! !!


Roche'

www.roche.com!!

Grenzacherstrasse!124!

Basel,!4070!

Switzerland!

Tel:!+41:9:732354295!


82,000+!employees!


Small!

Enzyme!categories! Molecular!biology!and!diagnostics!Expression!systems! E.,coli,,Pichia,!others!Capacity/scale! Bulk.!!In:house!production.!Key!People! Severin!Schwan,!CEO!Partnerships! NA!Customers! Global!Financial!Health! +++!Catalog!of!Enzymes! +++!Toll!Manufacturing! :!!

Roche!has!a!large!manufacturing!site!for!enyzmes!and!biotechnology!products!in!Penzberg,!Germany!

From!the!company!website:!“Headquartered!in!Basel,!Switzerland,!Roche!is!a!leader!in!research:focused!healthcare!with!combined!strengths!in!pharmaceuticals!and!diagnostics.!Roche!is!the!world's!largest!biotech!company!with!truly!differentiated!medicines!in!oncology,!virology,!inflammation,!metabolism!and!CNS.!Roche!is!also!the!world!leader!in!in:vitro!diagnostics,!tissue:based!cancer!diagnostics!and!a!pioneer!in!diabetes!management.”!

Roche!Diagnostics!acquired!Boehringer!Mannheim!(B:M)!in!the!late!1990s!and!has!developed!an!extensive!diagnostic!enzyme!business!that!incorporated!the!B:M!product!range!and!expanded!significantly!over!the!years.!!Headquarters!for!Roche!Diagnostics!in!Europe!is!in!Mannheim,!Germany,!with!manufacturing!and!R!&!D!in!Penzberg,!Germany.!

'

'

! ! !!


Roche'Diagnostics'GmbH''

Sandhoferstrasse!116!!

DE:68305!Mannheim!!

GERMANY!

! ! !Tel!+49:621:759!0!! ! !Fax!+49!621!759!2890!!http://www.roche.de/diagnostics/index.htm!

Roche!Diagnostics!GmbH!!

Nonnenwald!2!!

DE:82377!Penzberg!!

GERMANY!

+49:8856!60!0!

+49:8856!60!3896!

http://www.roche.de!

US'headquarters'for'Roche'Diagnostics'is'in'Indianapolis.'

Roche'Diagnostics'Corporation!

9115!Hague!Road!Indianapolis,!Indiana!46250!

USA!

+1:317:521:2000!

!

Products:!

Restriction!enzymes,!Polymerases,!Peroxidases,!!

Ligases,!Phosphatase,!Proteases,!Catalase! !

! ! !!


Rossari'Biotech'Limited'

http://www.rossari.com/!!

201:A!&!B,!Ackruti!Corporate!Park,!LBS!Marg,!

Next!to!GE!Gardens,!Kanjurmarg!(W.),!Mumbai!:!400!078!

India!

Tel:!+91:22:6123!3800!!

Fax:!+91:22:6123!3846!!!



200!employees!


Small!

Enzyme!categories! Leather,!textile,!detergent!enzymes,!food!and!juice,!pulp!and!paper,!winemaking!

Expression!systems! NA!Capacity/scale! Bulk.!!In:house!production.!Key!People! Founders!and!Directors:!Mr.Sunil!Chari!and!Mr.Edward!Menezes!Partnerships! Indozymes.com!is!an!authorized!distributor!for!Rossari!Customers! NA!Financial!Health! NA!Catalog!of!Enzymes! ++!(multiple!products!listed,!but!descriptions!are!sparse)!Toll!Manufacturing! :!!!

Rossari!is!a!very!diverse!company!with!many!product!offerings!in!different!sectors!including!everything!from!probiotics!to!construction!chemicals!to!knitting!oil.!!The!company!has!a!10!acre!manufacturing!site!capable!of!producing!4600!metric!tons!of!product!per!month.!!!

Products:!

Partially!not!specified,!likely!include:!

Xylanases!

Cellulases!

Catalase!

! ! !!


Pectinases!

Amylases!

Glucanases!

Proteases!

Phytase!

Lipases!

!

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! ! !!


S'I'CHEMICAL'INDUSTRIES''

www.papain.in!!

Gujar!Galli,!Shahada,!Tal:!Shahada!

Dist:!Nandurbar!!425409!Maharashtra!!

India!

Tel:!+91:2565:223735,!224135.!!

Tel:!+919881741435,!+919422791435!

Fax:!!+91:2565:223735!




Small!



Enzyme!categories! Brewing,!meat!processing,!human!health,!dairy,!detergents,!textiles,!baking,!starch!processing,!leather.!

Expression!systems! Extraction!from!plant!tissue.!Capacity/scale! Bulk.!!In:house!production.!Key!People! Mr.!Kishor,!Managing!Director!Partnerships! NA!Customers! NA!Financial!Health! NA!Catalog!of!Enzymes! +!Toll!Manufacturing! :!!

SI!Chemical!Industries!is!solely!focused!on!manufacturing!and!selling!the!enzyme!papain.!

Products:!

Papain!

!

! !

! ! !!


Sartorius'Stedim'Biotech'GmbH'

www.sartorius:stedim.com!!

Avenue!de!Jouques!ZI!des!Paluds!!

BP1051!AUBAGNE!Cedex,!13781!!

France!

Year!Founded! 1870!(as!parent!Sartorius)!Size!($!or!employee!count!or!both)!

3156!employees,!ca.!600!million!Euros!annual!


Small!percentage!

Enzyme!categories! DENARASE!endonuclease!from!c:LEcta!Expression!systems! Recombinant!expression!in!Bacillus,sp.!Capacity/scale! 1!megaunit!to!500!Kg!batches!offered!Key!People! Joachim!Kreuzburg,!Chairman!of!the!Board,!CEO!Partnerships! c:LEcta!provides!the!endonuclease!Customers! NA!Financial!Health! +++!Catalog!of!Enzymes! +!(just!one!enzyme!product)!Toll!Manufacturing! :!!

Sartorius!Stedim!Biotech!is!a!public!company!with!74%!ownership!by!parent!company!Sartorius!AG.!!!

According!to!the!company!website:!“Sartorius!Stedim!Biotech!is!a!leading!provider!of!cutting:edge!equipment!and!services!for!the!development,!quality!assurance!and!production!processes!of!the!biopharmaceutical!industry.!Its!integrated!solutions!covering!fermentation,!cell!cultivation,!filtration,!purification,!fluid!management!and!lab!technologies!are!supporting!the!biopharmaceutical!industry!around!the!world!to!develop!and!produce!drugs!safely,!timely!and!economically.!Sartorius!Stedim!Biotech!focuses!on!single:use!technologies!and!value:added!services!to!meet!the!rapidly!changing!technology!requirements!of!the!industry!it!serves.!Strongly!rooted!in!the!scientific!community!and!closely!allied!with!customers!and!technology!partners,!the!company!is!dedicated!to!its!philosophy!of!“turning!science!into!solutions.”!Headquartered!in!Aubagne,!France,!Sartorius!Stedim!Biotech!is!listed!on!the!Eurolist!of!Euronext!Paris.!With!its!own!manufacturing!and!R&D!sites!in!Europe,!North!America!and!Asia!and!a!global!network!of!sales!companies,!Sartorius!Stedim!Biotech!enjoys!a!worldwide!presence.!Its!key!manufacturing!and!R&D!site!is!in!Germany.!The!company!employs!approx.!3,000!people,!and!in!2012!earned!sales!revenue!of!544.0!million!euros.”!

Products:!DENARASE!endonuclease!from!c:LEcta' !

! ! !!


Scott'Laboratories'

www.scottlab.com!!

2220!Pine!View!Way!

Petaluma,!CA!94954!

USA!

Tel:!+1:707:765:6666!



About!75!employees!


Small!

Enzyme!categories! Winemaking!!Expression!systems! NA!Capacity/scale! Bulk.!!No!in:house!production!Key!People! Bruce!Scott,!President!Partnerships! Scottlabs!sells!its!own!branded!enzymes!but!also!those!of!Lallemand!and!

Oenobrands.!Customers! NA!Financial!Health! ++!Catalog!of!Enzymes! ++!Toll!Manufacturing! :!!

From!the!website:!“For!over!seventy:five!years!Scott!Laboratories!has!been!meeting!the!needs!of!the!beverage!industry!with!innovative!solutions!and!products!including!fermentation!goods,!filtration!media,!equipment,!packaging!products!and!laboratory!services.”!

Products:!

Pectinases!

Beta:glucanases!

Hemicellulases!

Cellulases!

' '

! ! !!


Season'Chemicals'and'Dyestuffs'

www.sesaonchemicals.com!!!

Flat!01,!28/F.,!EW!International!Tower!

120!:124!Texaco!Road,!Tsuen!Wan,!N.T.!!

Hong!Kong!

Tel:!!(852)!2609!0698,(852)!2609!0847,(852)!2408!3221,(852)!2409!0170!!!!

Fax:!(852)!2609!0715!



NA!


Small!

Enzyme!categories! Textiles!Expression!systems! NA!Capacity/scale! Bulk.!!No!in:house!production!Key!People! NA!Partnerships! gets!enzymes!from!DuPont!Industrial!Biosciences!(fmr.!Genencor).!!!Customers! NA!Financial!Health! NA!Catalog!of!Enzymes! +!Toll!Manufacturing! :!!

Season!Chemicals!is!a!producer!of!materials!used!in!textile!processing,!including!enzymes.!

Products:!

Catalase!

Pectinase!

Cellulase!

Amylases!

!

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Sekisui'Enzymes'

http://www.sekisuienzymes.com/!!

Sekisui!Diagnostics!(UK)!Ltd.!

50!Gibson!Drive!

Kings!Hill,!West!Malling!

Kent!ME19!4AF!

UK!

Tel:!+44!(0)!1732!220022!

Fax:!+44!(0)!1732!220024!



NA!

Company!type! Private.!!Company!is!part!of!Sekisui!Diagnostics!Ltd.!which!is!in!turn!part!of!Sekisui!Chemical,!a!large!public!company.!


NA!

Enzyme!categories! Nearly!100!enzymes!for!diagnostic!applications.!Expression!systems! Wide!variety!of!organisms.!!!Capacity/scale! Up!to!6,000!L!fermentations!in:house!production.!Key!People! Nick!Major,!Scientific!Director!Partnerships! NA!Customers! NA!Financial!Health! +++!Catalog!of!Enzymes! +++!Toll!Manufacturing! ++!!

Sekisui!originated!from!Whatman!Biochemicals,!a!supplier!of!enzymes!that!was!founded!in!1971.!!!

From!the!company!website:!“Sekisui!Enzymes,!a!Sekisui!Diagnostics!business!unit,!is!committed!to!the!discovery,!development,!manufacture!and!distribution!of!enzymes!and!speciality!biochemicals!for!the!global!healthcare!market.!With!a!proven!track!record!over!40!years,!our!quality,!expertise!and!customer!focus!are!the!reasons!why!organisations!choose!Sekisui!Enzymes!as!their!partner!of!choice.!Our!parent!organisation,!Sekisui!Chemical,!is!an!approximately!$10!billion!dollar!organization!headquartered!in!Tokyo!that!employs!over!20,000!people,!with!over!200!companies!(comprised!of!approximately!115!domestic!subsidiaries,!75!overseas!subsidiaries!and!17!affiliates).!!Sekisui!Chemical!is!organized!into!

! ! !!


three!main!areas:!a!housing!company,!an!urban!infrastructure!and!environmental!products!company!and!a!High!Performance!Plastics!company.!Within!High!Performance!Plastics!is!Sekisui!Medical!and!within!the!Sekisui!Medical!organization!is!Sekisui!Diagnostics.”!

Products:!

1:5:Anhydroglucitol:6:Phosphate!Dehydrogenase! !!

12!α:Hydroxysteroid!Dehydrogenase! !

3!α:Hydroxysteroid!Dehydrogenase! !!

3:Hydroxybutyrate!Dehydrogenase! !!

Acyl:CoA!Oxidase! !!

Acyl:CoA!Synthetase! !!

ADP–dependent!Hexokinase! !

Alcohol!Dehydrogenase!A!(Secondary)! !

Alcohol!Dehydrogenase!B!(Secondary)! !!

Alcohol!Dehydrogenase!HI1! !!

Alcohol!Dehydrogenase!HI2! !!

Alcohol!Dehydrogenase!YK1! !

Alcohol!Oxidase!!Candida!sp.!

Alcohol!Oxidase!!Yeast! !

Alkaline!Phosphatase! !!

Ascorbate!Oxidase! !

Beta:Lactamases!

Bilirubin!Oxidases!

BpNPG₇!! ! !

Catalase! !

Cholesterol!Dehydrogenase! !!

Cholesterol!Esterase! !!

! ! !!


Cholesterol!Oxidases! !!

Choline!Oxidase!!Arthrobacter!globiformis! !

CNPG₃! ! ! !

Colipase! !

Diacetinase! !

Diaphorase!(NADH)! !

Diaphorase!(NADPH)! !!

DNASE!B! !

Fructose:bisphosphate!Aldolase!HI1! !

Glucoamylase! !!

Glucokinase! !!

Glucose!1:dehydrogenase:NAD(P)! !!

Glucose!Dehydrogenase!(PQQ)! !Bacterial! !

Glucose!Dehydrogenase!FAD!Dependent! !!

Glucose!Dehydrogenase!NAD!Dependent! !!

Glucose!Oxidase! !!

Glucose:6:Phosphate!Dehydrogenase! !!

Glutamine!Synthetase! !

Glycerol!Kinases!

Glycerol!Phosphate!Oxidase!

Glycerophosphorylcholine!Phosphodiesterase! !!

Hexokinases!

Ketoamine!Oxidase! !!

L:α:Glycerophosphate!Oxidases!!

Laccase!!!

! ! !!


Lactate!Dehydrogenase!!!

Lactate!Oxidase!!!

Lipases! !!

Lysophospholipase! !

Malate!Dehydrogenases!

Maltase!(α:Glucosidase)! !!

Monoglyceride!lipase! !!

NAD!Synthetase! !!

Oxaloacetate!Decarboxylase! !

Penicillinase!!

Peroxidases! !

Phosphofructokinases! !!

Phosphoglucose!Isomerase! !

Phospholipases!!!

Purine!Nucleoside!Phosphorylase! !!

Pyruvate!Decarboxylase!!!

Pyruvate!Kinases!

Pyruvate!Oxidase! !!

Sarcosine!Oxidase! !

Sphingomyelinase! !!

Streptolysin!O! !!

Transketolase! !!

Tyramine!Oxidase! !!

Urease! !,!Uricase! !!

Xanthine!Dehydrogenase! !

! ! !!


Senson'Ltd'

www.senson.fi!!

P.O.Box!95!

Niemenkatu!18!

FI:15141!Lahti!

Finland!

Tel:!+358!3!864!364!

Fax:!+358!3!781!8918!



11:50!employees!

Company!type! Private,!part!of!the!Polttimo!Group!Enzyme!sales!absolute!and/or!as!a!percentage!of!company!sales!

Small!

Enzyme!categories! Dairy,!beverage,!baking.!Expression!systems! NA!Capacity/scale! Bulk.!!No!in:house!production.!Key!People! Jyrki!Heinimo,!Managing!Director!(CEO)!Partnerships! NA!Customers! NA!Financial!Health! NA!Catalog!of!Enzymes! +!Toll!Manufacturing! :!!

From!the!website:!“Senson!Ltd!develops,!produces!and!delivers!ingredients,!and!solutions!based!on!them,!to!the!beverage!and!food!industries!around!the!world.”!!

Products:!

Lactase!

Maltase!

Beta:amylase!

!

! ! !!


Shandong'Longda'BioBProducts'Co.,'Ltd.''

www.enzymeinchina.com!!

No.3!Yibo!Road!

Yishui!County!

Shandong!Province!276400!

China!!

Tel:!+86:539:2228377!!

Fax:!+86:539:2228377!

Email:!sales@longda:enzyme.com!!

Email:!gqw@longda:enzyme.com!!


NA!


Nearly!all!revenues!are!enzyme!sales!

Enzyme!categories! Alcohol!production,!starch!processing,!feed!and!food!processing,!textiles.!Expression!systems! Aspergillus,,Bacillus,,Trichoderma,Capacity/scale! Bulk.!!In:house!production.!Key!People! NA!Partnerships! NA!Customers! NA!Financial!Health! NA!Catalog!of!Enzymes! +!Toll!Manufacturing! :!!

Shandong!Longda!Bioproducts!specializes!in!manufacturing!enzymes!for!a!variety!of!industrial!applications.!!!

Products:!

Glucoamylase!

Alpha:amylases!

Pectinase!

! ! !!


Protease!

Cellulase!

Xylanase!

Pullulanase!

!

!

!

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! ! !!


SHIN'NIHON'CHEMICAL'CO.,'LTD.'

http://www.aichi:brand.jp/corporate/type/chemical/shin:nihon:e.html!!

19:10!Showa,!Anjyo,!Aichi!446:0063!!

Japan!

Tel:!+81:566:76:5171!


>120!employees!

Company!type! Owned!by!Aichi!Prefecture,!a!Japanese!group!of!companies!Enzyme!sales!absolute!and/or!as!a!percentage!of!company!sales!

Small!

Enzyme!categories! Food!Expression!systems! Aspergillus,!Trichoderma,,Rhizopus,,Candida,!wild:types!Capacity/scale! Large!scale!in:house!production!using!solid!(koji)!process!Key!People! NA!Partnerships! Partnered!with!Bio:Cat!for!distribution!in!the!USA.!!The!company!sells!

through!TAKABIO.!!!Customers! NA!Financial!Health! NA!Catalog!of!Enzymes! ++!!Toll!Manufacturing! :!!

Though!this!company!does!not!support!a!website!to!serve!English:speaking!markets,!it!is!one!of!the!larger!enzyme!producers!in!Asia,!and!Danisco’s!2009:2010!annual!report!identifies!it!as!a!significant!competitor.!!The!company!sells!through!the!company!Takabio:!http://www.takabio.com/!

From!the!company!website:!“SHIN!NIHON!CHEMICAL!manufactures!unique!enzyme!products!using!a!solid!(koji)!culture!system!that!allows!various!enzymes!to!work!in!synergy.!This!R&D:oriented!company!promotes!the!development!of!enzymes,!etc.!that!impose!less!chemical!load!on!the!environment.”!!

Products:!!

Cellulase!

Proteases!

Pectinase!

Amylases!

Galactosidase!

! ! !!


Phytase!

Hemicellulose!

Invertase!

Xylanase!

Catalase!

!

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! ! !!


SibEnzyme'Ltd'

http://www.sibenzyme.com/!!

2/12,!Ak.!Timakova!Street!!

Novosibirsk:117,!630117!

Russia!

Tel:!+7!3833!334991!

Fax:!+7!3833!336853!



NA!


NA!

Enzyme!categories! Molecular!biology!Expression!systems! NA!Capacity/scale! Lab!scale!in:house!production!Key!People! NA!Partnerships! USA!subsidiary!and!global!distributors!Customers! Global!Financial!Health! ++!(estimated)!Catalog!of!Enzymes! +++!(large!selection)!Toll!Manufacturing! :!!

From!the!company!website:!“SibEnzyme!Ltd.!(Siberian!Enzyme,!SE),!is!a!privately!owned!Russian!company!founded!in!1991.!SibEnzyme!Ltd.!is!located!in!Academtown!near!Novosibirsk!city!:!the!capital!of!Siberia!and!a!geographic!center!of!Russia.!SibEnzyme's!primary!focus!is!production!of!enzymes!and!related!products!for!molecular!biology,!PCR!and!genetic!engineering.!SE!product!line!includes!more!than!200!enzymes,!several!perfect!DNA!ladders,!high!quality!dNTPs!and!DNA!preparations.!SibEnzyme!Ltd.!is!one!of!the!leading!companies!in!restriction!endonucleases!production.!Sibenzyme!Ltd.!is!a!world!leader!in!research!and!development!of!new!DNA!endonucleases.!A!first!site:specific!DNA!nickase!was!found!and!characterized!at!SibEnzyme.”!

Products:!

More!than!200!enzymes:!!

! ! !!



Ligases!

Polymerases!

Endonucleases' '

! ! !!


SigmaBAldrich'

http://www.sigmaaldrich.com/!!

3050!Spruce!St.!

St.!Louis,!MO!63103!

USA!

Tel:!+1:800:325:3010!

Fax:!+1:800:325:5052!


About!9,000!employees!

Company!type! Public:!SIAL!Enzyme!sales!absolute!and/or!as!a!percentage!of!company!sales!

Small!

Enzyme!categories! Biocatalysis,!molecular!biology,!diagnostics.!Expression!systems! NA!Capacity/scale! Lab!scale.!!Likely!no!in:house!production.!Key!People! Rakesh!Sachdev,!President!and!CEO!Partnerships! Collaborates!with!hundreds!of!manufacturers!globally!for!materials!supply.!Customers! Global!Financial!Health! +++!Catalog!of!Enzymes! ++!Toll!Manufacturing! :!!

From!the!website:!“Sigma:Aldrich!is!a!leading!Life!Science!and!High!Technology!company!whose!biochemical,!organic!chemical!products,!kits!and!services!are!used!in!scientific!research,!including!genomic!and!proteomic!research,!biotechnology,!pharmaceutical!development,!the!diagnosis!of!disease!and!as!key!components!in!pharmaceutical,!diagnostics!and!high!technology!manufacturing.!Sigma:Aldrich!customers!include!more!than!1.3!million!scientists!and!technologists!in!life!science!companies,!university!and!government!institutions,!hospitals!and!industry.!The!Company!operates!in!35!countries!and!has!nearly!9,000!employees!whose!objective!is!to!provide!excellent!service!worldwide.”!

Products:!

Several!hundred!enzymes;!extensive!list!for!research!and!diagnostics!

!

' '

! ! !!


SinoBios'

http://www.sinobios.com/!!

Suite!B903,!Tomson!Centre!

188!Zhangyang!Rd.!

Pudong!New!Dist.,Shanghai!200120!

China!!

Tel:!+86:21:58886205!



300!employees!


Substantial!portion!of!revenues!is!enzymes!

Enzyme!categories! Brewing,!food!processing,!textile,!leather,!pulp!and!paper,!feed.!!!Expression!systems! Assumed!to!be!many!including!Pichia!Capacity/scale! Bulk.!!Some!in:house!production.!Key!People! NA!Partnerships! Seeking!global!partners.!!Sells!enzymes!through!Prozomix!in!the!UK.!!!Customers! Global.!!Market!Proportion!of!the!Products:!20%!for!international!market;!

80%!for!China!market.!!SinoBios’!main!customers!include!Tsingtao!Brewery,!Carlsberg,!Asahi,!CRC,!Blueribbon,!Kingway,!AB!GmbH,!Dyadic,!etc.!!SinoBios!is!the!main!supplier!of!ethanol!enzymes!for!Tianguan!Group!Co.,!Ltd.!the!largest!alcohol!factory!in!China.!

Financial!Health! Appears!to!be!sound!and!growing!Catalog!of!Enzymes! +++!Toll!Manufacturing! :!!

SinoBios!sells!a!range!of!enzymes.!!It!both!imports!enzymes!into!China!that!others!make!and!sells!and!exports!enzymes!that!manufactured!by!SInoBios!and!its!partners.!!SynBios!is!actually!a!group!of!companies!involved!in!the!import/export,!manufacture,!and!distribution!of!mostly!enzymes!but!also!other!biotechnology!products.!

Products:!

Amylases!

Proteases!

! ! !!


Pectinase!

Beta:glucanases!

Glucose!oxidase!

Lipases!

Lipoxygenase!

Hexose!oxidase!

Papain!

Xylanase!

Cellulases!


Mannase!

!

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! ! !!


Specialty'Enzymes'and'Biotechnologies'Inc.'

http://www.specialtyenzymes.com/!!

13591!Yorba!Ave.!

Chino,!CA!91710!

USA!

Tel:!+1:909:613:1660!!

Fax:!+1:909:613:1663!


Specialty!Enzymes!and!Biotechnologies!is!the!USA!branch!of!the!India:based!global!enzyme!company!Advanced!Enzymes.!!The!US!subsidiary!is!managed!by!Mr.!Vic!Rathi.!!

The!markets!served!are!the!same!and!the!parent!company!in!india:!leather,!textile,!pharmaceutical,!animal!feed,!food,!paper,!environmental,!agriculture!and!speciality!applications.!!

For'more'information,'see'the'entry'for'Advanced'Enzymes.'

!

!

!

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SpheriTech'Ltd.'

http://www.spheritech.com!

The!Heath,!Business!&!Technical!Park!

Runcorn,!Cheshire!WA7!4QX!

United!Kingdom!

Tel:!+44!1928!511331!

[email protected]!


1:10!employees!


Products!consist!of!polyspheres!for!immobilization!of!enzymes!and!cells.!Additional!products!include!polymers!for!peptide!synthesis,!cell!culture!and!regenerative!medicine!!

Enzyme!categories! Biocatalysis!Expression!systems! NA!Capacity/scale! Laboratory!Key!People! Dr.!Don!Wellings,!Founder!and!CEO!Partnerships! NA!Customers! NA!Financial!Health! NA!Catalog!of!Enzymes! !Toll!Manufacturing! +!(immobilizes!enzymes!as!a!service,!but!does!not!produce!enzymes)!!

SpheriTech!provides!preparative!chromatography!and!custom!synthesis!of!peptides,!related!molecules!and!small!organics.!From!our!research!laboratories,!we!are!able!to!provide!consultancy!in!preparative!chromatography!plus!consultancy!in!peptide!synthesis!and!process!scale!peptide!synthesis.!Spheritech!has!invented!a!process!for!the!manufacture!of!super:macroporous!polymer!scaffolds!for!cell!culture.!This!novel!process!allows!for!a!more!precisely!controlled!pore!structure,!pore!volume!and!pore!dimension!than!could!not!previously!be!achieved.!

Products:!

Polysphere!suppors!for!immobilization!of!enzymes!

Polymers!for!immobilization!of!cells!!

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! ! !!


Sprin'Technologies'

http://www.sprintechnologies.com/!!

SPRIN!S.p.A.!

c/o!BIC!Incubatori!FVG!

Via!Flavia!23/1!

34148!Trieste!

Italy!

Tel:!+39!040!821492!



1:10!employees!


Sales!consist!of!immobilized!enzyme!products,!enzyme!immobilization!collaborative!revenues,!and!polymeric!materials!for!immobilization.!

Enzyme!categories! Biocatalysis!Expression!systems! NA!Capacity/scale! Capacity!claimed!for!immobilization!up!to!ton!scale!Key!People! Sara!Cantone,!Co:Founder!and!CEO!Partnerships! Collaborates!with!and!sells!enzymes!through!Iris!Biotech.!!Collaborated!with!

Purolite!on!one!immobilization!project.!!Collaborated!with!MetGen!Oy!for!immobilizing!laccases.!!SPRIN!distributes!its!products!and!services!in!the!US!through!Itochu!Chemicals!America!Inc.!

Customers! NA!Financial!Health! NA!Catalog!of!Enzymes! +!Toll!Manufacturing! +!(immobilizes!but!does!not!produce!enzymes)!!

Sprin’s!expertise!is!in!the!immobilization!of!enzymes,!and!the!company!offers!a!small!catalog!of!immobilized!enzymes!and!polymers!for!immobilization.!!Furthermore,!SPRIN!offers!enzyme!immobilization!as!a!service.!!Enzymes!which!the!company!has!worked!on!include!kinases,!monooxygenases,!nitrilases,!epoxide!hydrolases,!transaminases,!glucoamylase,!invertase,!dextranase,!and!laccases.!

Products:!

Immobilized!enzymes!including:!!

! ! !!


Galactosidase!

Endoinulinase!

Penicillin!G!amidase!(2!forms)!

Kit!of!12!immobilized!ketoreductases!

!

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SternEnzym'

http://www.sternenzym.de/!!!

Kurt:Fischer:Straße!55!!

22926!Ahrensburg!

Germany!

Tel:!+49!/!(0)!41!02!/!202:002!

Fax:!+49!/!(0)!41!02!/!202:020!



NA!

Company!type! Private,!owned!by!the!Stern:Wywiol!Gruppe!Enzyme!sales!absolute!and/or!as!a!percentage!of!company!sales!

Most!revenue!is!from!enzyme!sales.!

Enzyme!categories! Food!and!beverage!!Expression!systems! Many,!including!custom:developed!strains.!Capacity/scale! Bulk.!!Some!in:house!manufacturing.!Key!People! Lennart!Kutschinski,!Managing!Director!Partnerships! NA!Customers! NA!Financial!Health! NA!Catalog!of!Enzymes! +++!Toll!Manufacturing! :!!

From!the!website:!“Established!in!1988,!SternEnzym!was!quick!to!realize!the!significance!of!enzymes.!As!competent!enzyme!designers!we!create!multi:enzyme!compounds!for!the!production!of!baked!goods,!pasta,!dairy!products,!alcoholic!drinks!and!much!more!from!micro:organism!strains,!some!of!which!we!have!developed!ourselves.!We!create!each!enzyme!compound!individually,!in!close!cooperation!with!our!customers,!so!that!it!fits!the!customer's!frame!of!reference!exactly.”!

Products:!

Amylases!

Glucoamylase!

Hemicellulase!

! ! !!


Invertase!

Lactoperoxidase!

Lipase!

Pentosanase!

Protease!

Xylanase!!

Sulphydryl!oxidase!

!

!

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! ! !!


Strem'Chemicals,'Inc.'

http://www.strem.com/!!

7!Mulliken!Way!

Newburyport,!MA!01950:4098!!

USA!

Tel:!+1:978:499:1600!

Fax:!+1:978:465:3104!

Tel:!+1:800:647:8736!

Fax:!+1:800:517:8736!



55!employees!


Small!

Enzyme!categories! Biocatalysis!

Expression!systems! NA!Capacity/scale! Lab!scale.!!No!manufacturing!capacity!Key!People! Mike!Strem,!Founder!and!owner!and!President.!Partnerships! Johnson!Matthey!and!Codexis!provide!the!enzyme!kits!that!Strem!then!sells!

retail!Customers! Chemistry!companies!and!academia.!!Offices!in!USA!and!Europe.!Financial!Health! ++!(small!but!long!profitable!history)!Catalog!of!Enzymes! ++!Toll!Manufacturing! :!!

Strem!Chemicals!is!well:known!provider!of!chemical!catalysts!and!reagents!and!custom!chemistry!manufacturing!services,!and!has!recently!expanded!its!offerings!to!include!biocatalysts.!!Strem!was!started!in!1964!by!Dr.!Mike!Strem!and!currently!has!about!55!employees.!!!Strem’s!catalog!contains!more!than!4000!offerings.!!!

Products:!!

! ! !!


All!products!offered!individually!and!in!kit!format,!each!kit!with!multiple!enzymes!prpvided!by!Johnson!Matthey!and!Codexis.!


Ene!reductases!

Esterases!

Ketoreductases!

Transaminases!

Lipases!


Lipases!

' '

! ! !!


Sukahan'(WeiBfang)'BioBtechnology'Co.'Ltd'

www.sukahan.com!!

No.!1689!Wolong!East!Street!

High!&!New!Technology!Industrial!District!

Weifang,!Shandong!261061!

P.R.!China!

Tel:!+86!536:2225530!!400:991:8166!

Fax:!+86!536:2227077!



About!50!employees!

Company!type! Private,!Australian!ownership!Enzyme!sales!absolute!and/or!as!a!percentage!of!company!sales!


Enzyme!categories! Textile,!pulp!and!paper,!animal!feed,!wastewater!Expression!systems! Bacillus,,Aspergillus,!others!likely!Capacity/scale! Bulk!manufacturer!Key!People! NA!Partnerships! NA!Customers! NA!Financial!Health! NA!Catalog!of!Enzymes! ++!Toll!Manufacturing! :!!

From!the!company!website:!“Sukahan!(Weifang)!Bio:Technology!Co.,!Ltd.!specializes!in!the!manufacture!of!various!kinds!industrial!&!commercial!enzyme!preparations!and!related!product!lines.!Over!the!years,!the!company!has!steadily!expanded!its!products!and!is!now!catering!to!diverse!industries!including!pulp!and!paper!industry,!textile!industry,!agricultural!and!aquaculture!industry,!animal!feeds,!commercial!and!household!sectors!and!many!more.”!

Products:!

Xylanase!

Beta:glucanase!

! ! !!


Proteases!

Cellulases!

Pectinases!

Amylases!

Lipases!

Phytase!

Glucoamylases!

!

!

!

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! ! !!


Sunson'Industry'Group'Company'Limited'

http://www.chinaenzymes.com/!!

Suite!628,!China!Minmetals!Building!

Block!4!Anhuili!

Chaoyang!District,!Beijing,!100101!

China!

Tel:!+86:10:58603691!!

Fax:!+86:10:58603690!



More!than!500!employees!


Nearly!all!revenues!are!enzyme!sales.!

Enzyme!categories! Animal!feed,!food,!brewing,!textile,!leather,!and!ethanol.!Expression!systems! NA!Capacity/scale! Bulk.!!In:house!manufacture.!Key!People! NA!Partnerships! NA!Customers! Exports!to!30!countries!as!well!as!the!home!base!of!China!Financial!Health! NA!Catalog!of!Enzymes! ++!Toll!Manufacturing! :!!

From!the!company!website:!“Sunson!Industry!Group!Co.,!Ltd.!is!a!recognized!leader,!engaged!in!exploring,!researching,!manufacturing!and!marketing!the!enzyme!industry!in!China!and!in!the!world.!In!1996,!Sunson!started!enzyme!business!in!China.!After!a!decade!with!our!full!efforts,!Sunson!has!grown!to!be!a!group!enterprise!with!2!R&D!centers,!4!manufacturing!bases,!over!30!branches!and!subsidiary!companies,!and!more!than!500!employees!involving!approximately!50!R&D!staff.!Armed!with!expertise,!we!Sunson!dedicate!into!the!industries!of!animal!feed,!food&!brewing,!textile&leather!and!ethanol.!We!provide!not!only!state:of:the:art!enzymes,!but!also!complete!supports!and!solutions.”!

Products:!

Amylases!

! ! !!


Glucoamylase!

Phytase!

Proteases!

Cellulase!

Beta:glucanase!

Xylanase!

Pectase!

Glucose!oxidase!

!

!

' '

! ! !!


SynBiocat'

http://www.synbiocat.hu/!!

Lázár!deák!u!4/1!Budapest,!1173!!

Hungary!



1:10!employees!


NA!

Enzyme!categories! Biocatalysis!Expression!systems! NA!Capacity/scale! Bulk!in!partner!facility.!!Key!People! László!Poppe,!Co:founder!and!CEO;!Zoltán!Boros,!Co:founder!Partnerships! Partnered!with!Fermentia.!!Fermentia's!fermentation!capacity!is!ideally!

suited!to!support!bacterial,!fungal!and!recombinant!fermentations!from!10!to!1000!litre!scale.!The!plant!is!also!equipped!with!separation!and!purification!capabilities!for!down!stream!processing.!

Customers! NA!Financial!Health! NA!Catalog!of!Enzymes! +!Toll!Manufacturing! +!!

From!the!company!website:!“SynBiocat!was!founded!in!2010!as!a!spin:off!company!of!Budapest!University!of!Technology!and!Economics!(BME)!with!R&D!facilities!at!BME!and!enzyme!production!facilities!at!the!pilot!plant!of!Fermentia!Ltd.!We!exploit!almost!30!years!expertise!in!synthetic!biocatalysis!with!remarkable!references!and!co:operations!with!industrial!and!academic!partners.!!We!offer!solutions!in!the!field!of!biocatalysis!and!synthetic!technologies!including!enzyme!screening!and!production,!biocatalyst!immobilization!and!chemoenzymatic!process!development.!!We!produce!the!robust!ImmBiocat!product!family!of!immobilized!enzymes!or!wholecell!systems.!!We!have!knowledge!and!technologies!in!synthetic!applications!of!ImmBiocat’s!in!various!types!of!bioreactors!including!batch!and!continuous:flow!systems.”!

Products:!

Immobilized!lipases!

' '

! ! !!


Syncozymes'

www.syncozymes.com!!

http://www.syncozymes.net!

Building!8,No.!128!Dieqiao!Road!

Hengmian!Town,!Pudong!

Shanghai!201319!

China!

Tel:!+1!86!21:6818:7185!

Fax:!+1!86!21:6818:7179!

Year!Founded! 2008!(as!Syncore)!Size!($!or!employee!count!or!both)!

About!$5:10!million!annually!Syncozymes,!11:50!employees!

Company!type! Private,!venture!funded!Enzyme!sales!absolute!and/or!as!a!percentage!of!company!sales!

The!company!offers!both!enzymes!and!chemical!intermediates.!

Enzyme!categories! Biocatalysis,!diagnostics.!Expression!systems! NA!Capacity/scale! Syncozymes’!fermentation!capabilities!include!fermenters!of!greater!than!

100!L!capacity,!and!the!company!offers!enzyme/chiral!products!on!a!100!kg!scale!with!a!3:4!month!lead!time,!likely!via!third:party!manufacture.!!!

Key!People! James!Wen!is!listed!as!Founder!and!CEO!in!his!LinkedIn!profile.!!Junhua!(Alex)!Tao!was!formerly!the!CEO,!but!has!since!left!to!lead!EnzymeWorks!and!Metabomics.!

Partnerships! Acore!is!the!US!division!of!the!Chinese!company!Syncozymes!Customers! NA!Financial!Health! +!(a!CRO/CMO,!which!have!experienced!headwinds!and!uneven!revenues)!Catalog!of!Enzymes! +++!(extensive)!Toll!Manufacturing! +!(small!scale)!!

Syncozymes!offers!its!extensive!catalog!of!products!for!sale!(enzymes,!enzyme!kits,!and!chiral!enzyme:derived!chemicals),!and!offers!research!and!development!services!on!a!fee:for:service!basis.!!The!catalog!includes!hundreds!of!enzymes!in!many!enzyme!classes!including!ene!reductases,!ketoreductases,!transaminases,!lipases,!proteases,!amidases,!nitrilases,!nitro!reductases,!alcohol!oxidase,!glycosidase,!nitrile!hydratase,!cytochrome!P450s,!and!many!others.!!Syncozymes!is!also!a!distributor!in!China!of!products!from!the!Dutch!enzyme!immobilization!company,!ChiralVision.!!!

! ! !!


Syncozymes’!website!reveals!experience!and!equipment!for!chemical!research!and!development.!!The!listed!capabilities!for!protein!engineering!suggest!that!the!company!is!capable!of!directed!evolution,!DNA!suffling,!and!rational!design.!!The!company!website!lists!capabilities!in!bioinformatics,!genome!mining,!and!high:throughput!screening.!!No!proprietary!new!technologies!are!listed,!and!the!company’s!biology!department!includes!a!protein!engineering!group,!a!molecular!biology!group,!a!biotransformation,!and!a!fermentation!group.!!The!company!also!lists!enzyme!immobilization!as!a!skill.!

Products:!

The!catalog!includes!hundreds!of!enzymes!in!many!enzyme!classes!including!the!following!in!individual!and!kit!format:!!

Ene!reductases!!

Ketoreductases!

Transaminases!

Lipases!

Proteases!

Amidases!

Nitrilases!

Nitro!reductases!

Alcohol!oxidases!

Glycosidases!

Nitrile!hydratases!

Cytochrome!P450s!

Aldolases!


Amino!acid!dehydrogenases!



3a:hydroxysteroid!dehydrogenase!

Bilirubin!oxidase!

! ! !!


Uricase!

Ascorbate!oxidase!

Peroxidase!

Xanthine!oxidase!


Glycerol!kinase!

Pyruvate!kinase!

Urease!

Adenosine!deaminase!

!

' '

! ! !!


Takabio'

http://www.takabio.com/!!

Parc!d'activités!Angers:Beaucouzé!!

4!rue!Joseph!Fourier!:!49070!Beaucouzé!!

France!

Tel:!+!33(0)2!41!88!66!66!!

Fax:!+!33(0)2!41!20!89!67!



NA!


100%!

Enzyme!categories! Food!Expression!systems! Mostly!Aspergillus,!some!Trichoderma,,Rhizopus,,Candida,!etc.!Capacity/scale! Large,!through!partner.!!No!in:house!production.!Key!People! NA!Partnerships! Partner!is!Shin!Nihon!Chemical!in!Japan,!which!supplies!all!the!product.!Customers! NA!Financial!Health! NA!Catalog!of!Enzymes! +++!Toll!Manufacturing! :!!

From!the!website:!“TAKABIO!has!been!created!to!represent,!sell!and!distribute!the!enzymes!produced!by!SHIN!NIHON!CHEMICAL!from!Japan.!The!name!TAKABIO!is!a!tribute!to!Jokichi!TAKAMINE!and!“BIO”!from!“Biology”,!the!science!of!life.”!

Products:!

Cellulase!

Proteases!

Pectinase!

Amylase!

Galactosidase!

! ! !!


Phytase!

Hemicellulose!

Invertase!

Xylanase!

Catalase!

!

! ! !!


TebuBbio'

http://www.tebu:bio.com!!

39!Rue!de!Houdan!BP!!

15!Le!Perray!en!Yvelines,!78612!!

France!!

Tel:!+33!1!30!46!39!00!

Fax:!+33!1!30!46!39!11!!

Email:!donald.van.dijk@tebu:bio.com!!


51:200!



Enzyme!categories! Molecular!biology,!life!science,!diagnostics.!Expression!systems! E.,coli!and!the!HEK293!cell!line!Capacity/scale! Lab!scale.!!Some!in:house!production.!Key!People! Donald!van!Dijk,!General!Manager!Partnerships! Sells!enzymes!from!third!parties!in!addition!to!its!own!Customers! Europe!Financial!Health! NA!Catalog!of!Enzymes! +++!Toll!Manufacturing! +!!

From!the!company!website:!“With!9!local!offices!in!Europe,!tebu:bio!is!a!European!company!specialised!in!providing!innovative!reagents!and!laboratory!services!in!Life!Sciences.!!Products!offered:!research!antibodies,!ELISAs,!Arrays,!Proteins!&!Peptides,!Cell:based!&!Functional!assays,!Primary!cells!&!Media,!SilenciX!KD!cell!lines,!Molecular!biology,!Biochemicals!(si/shRNA,!Compounds,!Lipid!research!tools).!!Lab!services:!Protein!production!&!purification!(E.!coli,!HEK293,!yeast.),!Cell!Biology!(cell!amplification!&!differentiation,!cell:line!engineering)!Molecular!biology!(nucleic!cloning,!sub:cloning),!Bio:assays!(gene!reporter!&!nuclear!receptor!assays,!outsourcing!of!assays!commercialised!by!tebu:bio).”!

Products:!

Tebu:bio!offers!nearly!2,000!enzyme!offerings.!!Extensive!catalog!for!life!science,!molecular!biology,!and!epigenetics!enzymes.!!! !

! ! !!


Tegaferm'Holding'GmbH'

www.tegaferm.com!!

2372!Giesshuebl!bei!Wien!

Schillerstrasse!26!a!

Austria!

Tel:!+43!/2236/205!189!

Fax:!+43!/2236/205!18919!



Small!


Most!revenues!from!enzymes!

Enzyme!categories! Distilling,!fruit!juice,!brewing!and!baking,!specialty!enzymes!for!technical!and!food!applications!

Expression!systems! NA!Capacity/scale! Bulk,!in:house!production!capability!unlikely!Key!People! Theodor!Gams,!Founder!Partnerships! Distributors:!G.!Keynan!(Israel),!TOO!(Ukraine),!Brenntag!(Russia)!Customers! Russia,!Baltic!states,!EU!Financial!Health! NA!Catalog!of!Enzymes! ++!Toll!Manufacturing! :!!

From!the!company!website:!“Tegaferm!Holding!GmbH!initially!specialized!in!the!distribution!of!enzymes!to!Russia,!Ukraine!and!the!Baltic!countries.!Due!to!excellent!results,!the!sales!organisation!is!rapidly!expanding!by!co:operating!with!various!companies,!especially!in!Central:!and!Eastern!Europe,!where!tegaferm!is!in!a!postion!to!offer!their!enzymes!competitively.!Depending!on!agreements,!tegaferm!sells!also!directly!to!end:users!in!special!fields!of!enzyme!application.!The!main!industrial!markets!for!tegaferm!Holding!GmbH!are!distilling,!fruit!juice,!brewing!and!baking,!but!also!specialty!enzymes!for!technical!and!food!applications!are!supplied.”!

Products:!

Alpha:amylase!

Glucoamylase!

! ! !!


Papain!

Proteases!

Beta:glucanase!

Pectinases!

Lysozyme!

Xylanase!

Phytase!

Cellulase!

Transglutamase!

Catalase!

Invertases!

Bromelain!

!

!

!

!

' '

! ! !!


Tex'Biosciences'

http://www.texbiosciences.com/!!

“Textan!House"!75,!Fourth!Avenue!

Ashok!Nagar,!Chennai!:!600!083!!

India!

Tel:!+91:44:42988700!

Fax:!+91:44:42988787!



More!than!200!employees!


Most!revenues!are!from!enzyme!sales.!

Enzyme!categories! Leather,!animal!feed,!pulp!and!paper,!detergent!and!pharmaceuticals.!Expression!systems! Non:GMO!Capacity/scale! Bulk.!!In:house!production.!Key!People! R.P!Krishnamachari,!Managing!Director!(CEO)!Partnerships! NA!Customers! Sells!throughout!Asia,!also!sells!in!Africa!and!Europe.!Financial!Health! NA!Catalog!of!Enzymes! ++!Toll!Manufacturing! NA!!

From!the!company!website:!“Tex!Biosciences!(P)!Limited!evolved!from!its!modest!beginning!as!a!basic!leather!chemical!manufacturer!in!1979!to!currently!serving!the!industrial!needs!of!Leather,!Poultry,!Piggery,!Aquaculture,!Pulp!&!Paper,!Detergent!and!Pharmaceutical!markets.!The!Core!Strength!of!Tex!Biosciences!is!the!high!strain!productivity!(all!Non:GMO)!and!its!superior!formulation!&!application!technology.!The!organization!takes!pride!in!being!OEM!grass!root!enzyme!manufacturer!and!not!merely!a!formulator!or!trader!of!enzymes.”!!

Products:!

Proteases!

Lipases!

Xylanases!

! ! !!


Pectinase!

Phytase!

Cellulase!

Amylases!

! !

! ! !!


The'Seydel'Companies'

www.seydel.com!'

244!John!B.!Brooks!Rd.!

Pendergrass,!GA!30567!

USA!

Tel:!+1:706:693:2266!

Fax:!+1:706:693:2074!



50+!employees!


Small!

Enzyme!categories! Textiles!Expression!systems! NA!Capacity/scale! Bulk.!!In:house!production!unclear.!Key!People! Scott!Seydel,!Sr.,!President!and!CEO!Partnerships! NA!Customers! NA!Financial!Health! NA!Catalog!of!Enzymes! ++!Toll!Manufacturing! :!!

From!the!website:!“The!Seydel!Companies!is!recognized!around!the!world!as!the!premier!formulator!of!specialty!process!chemicals!and!is!well:poised!to!enjoy!another!century!of!growth.!The!Seydel!Companies!develop,!manufacture!and!market!specialty!chemicals!for!the!textile!&!apparel,!paper!&!packaging,!personal!care,!agricultural,!and!metalworking!industries!and!provide!toll:manufacturing,!technical!laboratory!and!warehousing!services!at!our!production!facilities!in!Georgia!and!North!Carolina.”!

Products:!

28!enzymes,!including!formulations!of:!

Laccase,!Amylases,!Cellulases,!Catalase!

' '

! ! !!


Thermo'Fisher'Scientific'

http://www.thermoscientific.com/!!

81!Wyman!Street!

Waltham,!MA!02454!

USA!

Tel:!+1:781:622.1000!

Tel:!+1:800:678:5599!

Fax:!+1:781:622:1207!

Year!Founded! 1902!(as!Fisher!Scientific)!Size!($!or!employee!count!or!both)!

40,000!

Company!type! Public:!TMO!Enzyme!sales!absolute!and/or!as!a!percentage!of!company!sales!

Small!

Enzyme!categories! Molecular!biology!!Expression!systems! NA!Capacity/scale! Lab!scale.!!In:house!production.!Key!People! Marc!N.!Casper,!President!and!CEO!Partnerships! NA!Customers! Global!Financial!Health! +++!Catalog!of!Enzymes! ++!(large!selection!of!restriction!enzymes)!Toll!Manufacturing! :!!

From!the!company!website:!“Thermo!Fisher!Scientific!is!an!American!precision!laboratory!equipment!company!that!was!created!in!2006!by!the!merger!of!Thermo!Electron!and!Fisher!Scientific.!!Thermo!Scientific!FastDigest!enzymes!are!an!advanced!line!of!restriction!enzymes!that!create!a!new!standard!in!DNA!digestion.!During!our!30!years!of!restriction!enzyme!research,!we!compiled!one!of!the!largest!collections!of!restriction!enzyme!producing!bacterial!strains!in!the!industry.”!!

Products:!

Include!176!FastDigest®!restriction!enzymes.!!Include!Phusion!polymerase!and!other!enzymes!from!Finnzymes!and!Fermentas,!both!of!which!Thermo!bought!in!2010.!


Polymerases' !

! ! !!


Toyobo'Co.'Ltd.'

http://www.toyobo:global.com/!!

2:8,!Dojima!Hama!2:chome!

Kita:ku,!Osaka!530:8230!

Japan!

Tel:!+81:6:6348:3111!

Fax:!+81:6:6348:3206!


10,500!employees!

Company!type! Public:!TYO!Enzyme!sales!absolute!and/or!as!a!percentage!of!company!sales!

Relatively!small!

Enzyme!categories! Diagnostics.!Expression!systems! Many!Capacity/scale! Bulk.!!In:house!production!likely.!Key!People! Ryuzo!Sakamoto,!President!and!CEO!Partnerships! NA!Customers! Global!Financial!Health! +++!Catalog!of!Enzymes! +++!Toll!Manufacturing! :!!

Toyobo!is!a!group!of!companies!that!together!focus!on!three!general!areas:!Films!and!Functional!Polymers,!Industrial!Materials,!and!Life!Science.!!In!enzyme!products,!Toyobo!specializes!in!thermostable!enzymes!for!diagnostic!applications.!

Products:!N:Acetylneuraminic!acid!aldolase,!alkaline!phosphatase,!alkalophilic!proteinase,!ascorbate!oxidase,!cholesterol!esterase,!cholesterol!oxidase,!choline!oxidase,!creatine!amidinohydrolase,!creatinine!amidinohydrolase,!creatinine!deiminase,!diaphorase,!formaldehyde!dehydrogenase,!D:fructose!dehydrogenase,!beta:galacotosidase,!glucoamylase,!glucose!dehydrogenases,!glucose!oxidase,!glucose:6:phosphate!dehydrogenase,!alpha:glucosidase,!beta:glucosidase,!glutamate!dehydrogenases,!glycerol!dehydrogenase,!glycerol:3:phosphate!dehydrogenase,!glycerol!kinase,!L:alpha:glycerophosphate!oxidase,!hexokinase,!p:hydroxybenzoate!hydroxylase,!D:3:Hydroxybutyrate!dehydrogenase,!invertase,!lactate!dehydrogenase,!lactate!oxidase,!leucine!dehydrogenase,!lipases,!malate!dehydrogenase,!peroxidase,!pyruvate!oxidase,!pyruvate!kinase,!sarcosine!oxidase,!superoxide!dismutase,!urease,!uricase,!xanthine!oxidase,!others.!

! ! !!


TransBiodiesel'

http://www.transbiodiesel.com/!!

P.O.Box!437!

Shfar:Am!!20200!

Israel!

Tel:!+972:4:9504523!

Fax:!+972:4:9504525!!



1:10!employees!


NA!

Enzyme!categories! Immobilized!lipases!for!transesterification!of!oils!and!fats!to!generate!biodiesel.!!!

Expression!systems! NA!Capacity/scale! NA!Key!People! Sobhi!Basheer,!CEO!and!Founder!Partnerships! Partnership!with!Purolite!for!the!immobilization!of!lipases.!!At!least!7!scale:

up!trials!undertaken.!Customers! NA!Financial!Health! NA!Catalog!of!Enzymes! +!Toll!Manufacturing! NA!!

From!the!company!website:!“TransBiodiesel!produces!immobilized!enzyme:based!biocatalysts!for!production!of!first!and!second!generation!biodiesel!fuels,!complying!with!ASTM!and!EN!specifications.!Biocatalysts!are!environment:friendly,!and!enable!the!use!of!first!and!second!generation!feedstocks,!while!lowering!the!total!production!costs!of!biodiesel!fuels.”!

Products:!

Immobilized!lipases!

!

' '

! ! !!


TriBTex'Co'(Canada)'

http://www.tritex.com/!!

Tri:Tex!co!inc.!

1001!boulevard!Industriel!

Saint:Eustache,!Qc!!J7R!6C3!

Canada!

Tel:!+1:800:363:2660!!

Tel:!+1:450:974:1001!

Fax:!+1:!450:974:0162!!





Small!

Enzyme!categories! Textiles!Expression!systems! Trichoderma!and!Bacillus!Capacity/scale! Bulk.!!In:house!production!unlikely.!Key!People! Naim!Laham,!CEO!Partnerships! NA!Customers! NA!Financial!Health! NA!Catalog!of!Enzymes! +!(relatively!small)!Toll!Manufacturing! :!!

From!the!company!website:!“Tri:Tex's!employees!create!the!basic!chemical!building!blocks!that!go!into!clothing,!construction!materials,!household!products,!etc.!!Tri:Tex!brings!together!comprehensive!resources!and!expertise!to!present!our!customers!with!high:quality!chemical!products,!services!and!solutions.!!Textile!:!Dyes!&!Auxiliaries,!Construction,!Adhesives!&!Coatings,!Acrylic!coatings,!Surfactants!&!Specialties,!Flooring,!Pigments,!Paper,!Carpet,!Leather.”!

Products:!

Cellulases,!Amylases,!Laccase! !

! ! !!


Ultra'BioBLogics'Inc.'

www.ublcorp.com!!

24!Sequin!Rigaud!QC,!J0P!1P0!

Canada!!

Tel:!+1:450:451:4195,!450:451:6277!

Fax:!+1:450:451:616!


NA!


Major!portion!of!revenues!from!enzyme!sales!

Enzyme!categories! Animal!feed!enzymes!Expression!systems! Trichoderma,,Aspergillus,,Bacillus,,Chaetomium,,S.,cerevisiae.!!Extraction!

from!papaya!and!pineapple.!Capacity/scale! Bulk.!!In:house!manufacture!implied.!Key!People! George!Pietras,!President!Partnerships! NA!Customers! Canada!and!international:!USA,!China,!Portugal,!Mexico.!Financial!Health! NA!Catalog!of!Enzymes! +++!Toll!Manufacturing! :!!

From!the!company!website:!“Manufacturers!and!suppliers!of!feed!mill!farm!animal!enzymes!phytase,!xylanase,!cellulase!amylase!supplements!biological!plant!growth!aids!regulators!and!bio!stimulants,!waste!water!treatment,!food!and!agriculture!waste!and!odor!control!biological!solutions,!biological!fertilizers!soil!treatment!acidifiers!alkalizers,!golf!course!turf!and!pond!supplies,!alfalfa!hay!preservatives,!corn!silage!forage!additives!and!inoculants,!septic!tank!and!grease!trap!treatment,!organic!environmentally!friendly!non!toxic!portable!toilet!sanitizers!cleaners!deodorants,!new!septic!tank!tablets!fizzytabs,!fiztabs,!dairy!beef!cattle!horn!fly!control,!new!water!soluble!poultry!and!swine!enzymes,!farm!animal!insect!control,!animal!health!and!nutrition!feed!supplements,!horse!care!health!and!nutrition!supplements,!products!for!beef!cattle,!dairy,!ultra!natural!plus!poultry!swine!enzyme!formulations.”!

Products:!

Xylanases!

Phytases!

! ! !!


Pectinase!

Proteases!

Galactosidase!

Amyloglucosidase!

Alpha:amylases!

Beta:glucanase!

Bromelain!

Papain!

Cellulases!

Lactase!

Hemicellulase!

Dextranase!

Glucose!oxidase!

Invertase!

!

!

' '

! ! !!


Unikbio'Biotech(Guangzhou)'Ltd'

www.unikbio.com!!

!#7!Nan!Yun!Wu!Road,!Science!City!

High!and!New!Technology!Industrial!Development!Zone!

Guangzhou!510663!

China!

Tel:!+86:20:32016813!!!!!!!!!

Fax:!+86:20:32016817!!



Small!


Major!revenue!source!

Enzyme!categories! Brewing,!fruit!and!vegetable,!baking,!pulp!and!paper.!Expression!systems! NA!Capacity/scale! Bulk.!!Blender!and!supplier,!no!in:house!production!Key!People! NA!Partnerships! NA!Customers! NA!Financial!Health! NA!Catalog!of!Enzymes! +!Toll!Manufacturing! :!!

From!the!website:!“Unikbio!Biotech(Guangzhou)!Ltd.,!a!leading!enzyme!manufacturer!and!supplier!in!China,!which!authenticated!as!High!and!New!Technology!Enterprise!by!Guangdong!Government.!We!supply!bulks!of!enzyme!products!to!grain!process,!animal!feed,!paper!pulp,!textile!and!other!industries,!furthermore,!supply!specialized!enzyme!preparations!and!blend!enzymes!to!food!industries,!including!(brewing,!fruit!and!vegetable!process,!baking,!proteolysis,!plant!extraction),!light!chemical!industry!and!pharmaceuticals!industry.”!

Products:!

Not!specified.!!!

!

! ! !!


Unitaka'

http://www.unitika.co.jp/!!

4:1:3!Kyutaro:machi!

Chuo:ku,!Osaka,!541:8566!!

Japan!!

Tel:!+81:6:6281:5695!


Large!global!corporation!

Company!type! Public:!UTN!Enzyme!sales!absolute!and/or!as!a!percentage!of!company!sales!

Very!small!

Enzyme!categories! Diagnostics,!biocatalysis.!Expression!systems! Mostly!thermophilic!organisms!Capacity/scale! Bulk.!!In:house!production.!Key!People! Kenji!Yasue,!President!and!CEO!Partnerships! NA!Customers! Global!Financial!Health! +++!Catalog!of!Enzymes! ++!!Toll!Manufacturing! !!

Unitaka!is!a!large!Japanese!group!of!companies!that!broadly!target!polymers!and!fibers,!advanced!materials,!chemicals,!and!health!and!medical!products.!

Products:!

Unitaka’s!enzyme!list!is!broad!and!includes!mostly!products!isolated!from!thermophilic!organisms!with!enhanced!thermostability,!purity,!and!storage!shelf!life:!!

Acetate!kinase!

Adenylate!kinase!

Alanine!dehydrogenase!

Alanine!racemase!


Diphorases!

! ! !!


Galactose!dehydrogenase!

Glucokinase!

Glucose!hydrogenase!


Alpha:glucosidase!

D:lactate!dehydrogenase!

Leucine!dehydrogenase!


Mutarotase!

Phenylalanine!dehydrogenase!

Phosphofructokinase!

6:Phosphogluconate!dehydrogenase!

Phosphoglucoisomerase!

Phosphoglycerate!kinase!

Phosphotransacetylase!

Polynucleotide!phosphorylase!

Pyruvate!kinase!


Sorbitol!dehydrogenase!

! !

! ! !!


VEMO'99'Ltd'&'VSV'Ltd!

http://www.vemo:vsv.com/!!

13!Shumen!str.!

1309!Sofia!

Bulgaria!

Tel:!+359!2!931!66!21!

Tel/Fax:!+359!2!931!10!91!

Email:!info@vemo:vsv.com;!info@vemo:feedadditives.com!!


11:50!employees!



Enzyme!categories! Animal!feed!and!baking.!Expression!systems! NA!Capacity/scale! !Bulk.!!In:house!production.!Key!People! Hristo!Zlatev!and!Nina!Zlateva,!Founders!Partnerships! NA!Customers! NA!Financial!Health! NA!Catalog!of!Enzymes! +!Toll!Manufacturing! NA!!

“VEMO!99!Ltd!was!founded!in!1999,!with!administrative!center!in!Sofia,!Bulgaria,!is!a!producer!of!standardised!herbal!extracts,!biologically!active!nutritional!supplements,!plant!and!enzyme!feed!additives.!The!herbal!nutritional!supplements!and!feed!additives!are!based!on!proprietary!company!produced!extracts!from!rare!Bulgarian!remedial!plants.!The!closed!production!cycle!guarantees!full!technological!and!analytical!control!of!the!produced!phyto!products.!In!the!composition!of!the!enzyme!premixes!are!included!highly!purified!enzymes!with!guaranteed!quality.”!

Products:!

Phytases!

Amylases!

Cellulases,!Hemicellulases! !

! ! !!


Verenium'(now'part'of'BASF)'

www.verenium.com!!

3550!John!Hopkins!Ct.!

San!Diego,!CA!92121!

USA!

Tel:!+1:800:523:2990!


Year!Founded! 1992!(first!as!Industrial!Genome!Science,!then!as!Diversa)!Size!($!or!employee!count!or!both)!

111!employees,!$50!million!in!revenues!

Company!type! Public,!stock!symbol!VRNM,!being!acquired!by!BASF!Enzyme!sales!absolute!and/or!as!a!percentage!of!company!sales!

Nearly!all!sales!are!enzymes,!some!collaborative!R+D!revenue!additional!

Enzyme!categories! Animal!fee,!oil!field,!biofuels,!pulp!and!paper,!textiles.!!Expression!systems! Many!Capacity/scale! Verenium!leases!facilities!from!Fermic!in!Mexico!to!manufacture!on!a!multi:

ton!scale,!pilot!facilities!are!in!San!Diego!CA!USA!Key!People! James!Levine,!President!and!CEO;!Janet!Roemer,!Exec.!VP!and!COO!Partnerships! DuPont,!Novus,!Tate!and!Lyle,!Weiss!Biotech,!Cargill!Customers! Global!Financial!Health! +++!(not!profitable!on!its!own,!Verenium!will!be!backed!by!BASF’s!excellent!

financial!health)!Catalog!of!Enzymes! ++!(about!10!enzymes)!Toll!Manufacturing! :!!

Verenium!has!collected!one!of!the!most!comprehensive!libraries!of!environmental!DNA.!!This!DNA!is!expressed!in!recombinant!hosts,!and!Verenium!can!screen!on!the!order!of!a!million!enzymes!per!day!using!its!custom:developed!high:throughput!platform.!!The!company!finds!enzymes!in!its!collection!and!optimizes!them!using!directed!evolution!for!commercial!uses!in!feed!and!food,!oil!field!processing,!textiles,!and!first!generation!grain!processing!for!biofuels.!!Due!to!its!access!to!DNA!from!unique!or!rare!sources,!Verenium’s!enzymes!are!often!significantly!differentiated!from!competitors’!offerings.!!This!differentiation!means!that!Verenium,!despite!its!small!size,!can!often!compete!with!the!larger!industrial!biotechnology!firms.!!The!company!formerly!had!a!joint!venture!with!BP!in!biofuels,!and!Verenium!sold!its!share!of!the!business!to!BP.!!!

In'September'of'2013,'BASF'announced'that'it'would'acquire'Verenium.!!The!acquisition!was!ex[ected!to!be!complete!by!the!end!of!2013.!BASF!will!likely!continue!to!offer!Verenium’s!current!selection!of!catalog!enzymes,!and!will!likely!end!collaborative!R+D!efforts!with!third!parties.!

! ! !!


Products:!

Phyzyme®!XP!Phytase!(Animal!Health!&!Nutrition)!

Fuelzyme®!Alpha:amylase!(Grain!Processing!–!Fuel!Ethanol)!

Deltazym®!GA!L:E5!Glucoamylase!(Grain!Processing!–!Fuel!Ethanol)!!

Deltazym®!APS!Protease!(Grain!Processing!–!Fuel!Ethanol)!!

Xylathin®!Xylanase!(Grain!Processing!–!Fuel!Ethanol)!

Pyrolase®!Cellulase!(Oilfield!Services!–!Hydraulic!Fracturing)!

Pyrolase®!HT!Cellulase!(Oilfield!Services!–!Hydraulic!Fracturing)!!

Eradicake®!Alpha:amylase!(Oilfield!Services!–!Mudcake!Removal)!!!

Luminase®!PB:100!Xylanase!(Industrial!Processes!–!Pulp!&!Paper)!!

Cottonase®!Pectate!lyase!(Textiles)!

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! ! !!


Veskim'

www.veskim.com!!

KARAOĞLANOĞLU!CAD!

ETEM!ZENGİN!İŞ!MERKEZİ!KAT:5!!

NO:25!SEYRANTEPE/İSTANBUL!

Turkey!

Tel:!+90!212!283!10!17!

Fax:!+90!212!282!80!38!



51:100!employees!


Very!small!

Enzyme!categories! Textiles!Expression!systems! None!Capacity/scale! Bulk.!!No!in:house!production.!Key!People! NA!Partnerships! NA!Customers! NA!Financial!Health! NA!Catalog!of!Enzymes! +!Toll!Manufacturing! :!!

The!company!imports,!produces,!exports,!and!markets!chemicals!in!food,!leather,!agriculture,!and!textiles.!

Products:!

Enzymes!for!stonewashing!and!desizing,!likely!cellulases!and!amylases.!

!

!

!

! ! !!


!

W42'Industrial'Biotechnology'GmbH'

http://www.w42biotechnology.de/!!

Lipper!Weg!192!

45772!Marl!

Germany!

Tel:!+49!(0)2365!9246772!



About!5!employees!



Enzyme!categories! Biocatalysis!Expression!systems! Pichia,,Streptomyces,,and!E.,coli,Capacity/scale! Likely!small!Key!People! Ansgar!Stratmann,!Managing!Director!(CEO)!Partnerships! Vibalogics!has!entered!into!an!exclusive!partnership!with!W42!Industrial!

Biotechnology!for!the!provision!of!protein!production!using!the!expression!system!Pichia!pastoris.!!Jiaozuo!Joincare!Biotechnological!Co.,!Ltd.!is!a!scale:up!partner!for!W42’s!soluble!and!immobilized!enzymes!up!to!a!ton!scale.!!Company!uses!materials!from!Resinion!(a!Mitsubishi!company)!for!immobilization!efforts.!

Customers! NA!Financial!Health! NA!Catalog!of!Enzymes! +!Toll!Manufacturing! +!!

W42!is!an!expert!at!protein!expression!in!Pichia,!and!it!both!licenses!out!this!platform!and!uses!it!for!protein!expression!development!for!customers.!!It!also!has!a!small!catalog!of!enzymes!and!immobilized!enzymes!for!sale.!!It!offers!contract!research!for!expression!of!proteins!in!Pichia!and!E.,coli,!for!developing!biocatalysts,!and!for!enzyme!production!development.!

!

!

! ! !!


Products:!

Immobilized!and!soluble!versions!of:!


Penicillin!G!acylases!

Penicilin!G!amidases!

Lipases!

D:hydantoinases!

!

!

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! ! !!


Wako'Pure'Chemical'Industries,'Ltd.'

http://www.wako:chem.co.jp!! !

1:2!Doshomachi!3:Chome!

Chuo:ku,!Osaka!540:8605!

Japan!

Tel:!+81!(6)!2033741!

Email:!cservice@wako:chem.co.jp!!


1500!employees!


Small!

Enzyme!categories! Diagnostics.!Expression!systems! NA!Capacity/scale! Lab!scale.!!In:house!production!likely.!Key!People! Shinzo!Kobatake,!President!Partnerships! Wako!sells!enzymes!from!third!parties!as!well!as!its!own!Customers! Global.!!Based!in!Japan,!the!company!also!has!offices!and!distributes!in!the!

USA!and!other!countries.!Financial!Health! +++!Catalog!of!Enzymes! ++!Toll!Manufacturing! :!!

Wako!sells!a!large!range!of!laboratory!chemicals,!specialty!chemicals!and!diagnostic!reagents.!!This!large!organization!sells!globally!but!especially!in!Japan,!USA,!and!Germany.!!!

Products:!

Beta:agarase!

Phosphatases!

Aldose!reductase!


Collagenase!

Creatine!kinase!

! ! !!


Proteases!


Beta:galactosidase!

Lipases,!soluble!and!immobilized!

Natto!kinase!

Trypsin!

!

!

!

!

!

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WeissBioTech'GmbH'

http://www.weissbiotech.com/!!

An!der!Hansalinie!48:50!

D:59387!Ascheberg!

Germany!

Tel:!+49!(0)!2593!919!386!

Fax:!+49!(0)!2593!919!393!



NA!


Significant!contributor!

Enzyme!categories! Biofuels,!starch!processing,!fruit!juice,!dairy,!meat,!brewing.!Expression!systems! NA!Capacity/scale! Bulk.!!No!in:house!production.!Key!People! NA!Partnerships! Verenium!is!the!manufacturer!of!most!of!the!enzymes!Customers! NA!Financial!Health! NA!Catalog!of!Enzymes! +!(small)!Toll!Manufacturing! :!!

WeissBiotech!is!a!distributor!of!Vernium!enzymes,!and!sells!yeast!nutrient!and!dairy!additives!as!well.!!!

Products:!

Alpha:amylase!

Glucoamylases!

Beta:glucosidase!

Proteases!

' '

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Worthington'Biochemical'Corporation'

www.worthington:biochem.com!!

730!Vassar!Ave!

Lakewood,!NJ!08701!

USA!

Tel:!+1:800:445.9603!or!+1:732:942:1660!!

Fax:!+1:800:368:3108!or!+1:732:942:9270!

Email:!custservice@worthington:biochem.com!!


50:100!employees!


Most!sales!are!enzymes.!

Enzyme!categories! Biocatalysis,!diagnostics,!molecular!biology,!life!sciences.!Expression!systems! Extraction!from!animal!and!plant!tissue,!and!microbial!fermentation.!Capacity/scale! Lab!scale!to!bulk.!!In:house!production.!Key!People! Von!Worthington,!President!Partnerships! NA!Customers! Distributors!in!28!countries,!universities,!commercial!users.!Financial!Health! ++!Catalog!of!Enzymes! +++!Toll!Manufacturing! :!!

Worthington!is!a!manufacturer!and!supplier!of!a!large!number!of!enzymes!and!proteins.!!The!company!has!been!around!a!long!time!and!supplies!enzymes!that!a!number!of!other!companies!sell!retail.!!The!company!also!sells!small!amounts!directly!to!primary!users.!

Products:!!

Actin;!DNA!Ligase,!T4;!Nuclease,!S1;!Adenosine!Deaminase;!DNA!Polymerase!I;!Nucleohistone;!Albumin,!Nuclease:Free;!DNA!Polymerase!I,!Klenow!Fragment;!Ovalbumin;!Alcohol!Dehydrogenase;!DNA!Polymerase,!Taq;!Oxalate!Decarboxylase;!Aldolase;!DNA!Polymerase,!T4;!Papain;!Amino!Acid!Oxidase,!D:;!Elastase;!Papain!Dissociation!System;!Amino!Acid!Oxidase,!L:;!Elastin;!Papain,!Chymo;!Amylase,!Alpha;!Galactose!Oxidase;!Pectinase;!Amylase,!Beta;!Galactosidase,!Beta;!Pepsin;!Arginase;!Glucose!Oxidase;!Peroxidase;!Asparaginase;!Glucose:6:Phosphate!Dehydrogenase;!Phosphatase,!Acid;!Aspartate!Aminotransferase;!Glucosidase,!Beta;!Phosphatase,!Alkaline;!Avidin;!Glucuronidase,!Beta;!

! ! !!


Phosphodiesterase!I;!Beta!Agarase;!Glutamate!Decarboxylase;!Phosphodiesterase!II;!Carbonic!Anhydrase;!Glyceraldehyde:3:Phosphate!Dehydrogenase;!Phosphoenolpyruvate!Carboxylase;!Carboxypeptidase!A;!Glycerol!Dehydrogenase;!Phosphoglucomutase;!Carboxypeptidase!B;!Glycerol!Kinase;!Phospholipase!A2;!Carboxypeptidase!Y;!Hemoglobin;!Phospholipase!C;!Casein,!Alpha;!Hepatocyte!Isolation!System;!Plasma!Amine!Oxidase;!Catalase;!Hexokinase;!Pokeweed!Antiviral!Toxin;!Cell!Isolation!Optimizing!System;!Histones;!Polynucleotide!Kinase,!T4;!Cellulase;!Hyaluronic!Acid;!Polyphenol!Oxidase;!Cholesterol!Esterase;!Hyaluronidase;!Protease,!Staph!aureus!(Endoproteinase!Glu:C);!Cholinesterase,!Acetyl;!Hydroxysteroid!Dehydrogenase;!Proteinase!K;!Cholinesterase,!Butyryl;!Lactate!Dehydrogenase;!Pyruvate!Kinase;!Chymotrypsin;!Lactate!Dehydrogenase,!L:!(Cytochrome!b2);!Reverse!Transcriptase,!Recombinant!HIV;!Chymotrypsinogen!A;!Lactoperoxidase;!Ribonuclease!A;!Clostridiopeptidase!A;!Leucine!Aminopeptidase;!Ribonuclease!B;!Clostripain!(Endoproteinase:Arg:C);!Lipase;!Ribonuclease!T1;!Collagen;!Luciferase;!Ribonuclease,!E:Rase™!RNase!Blend;!Collagenase;!Lysozyme;!Ribonucleic!Acid;!Collagenase!(Animal!Origin!Free);!Malate!Dehydrogenase;!RNA!Polymerase;!Collagenase/Neutral!Protease!(STEMzyme™);!Maltase;!RNA!Polymerase,!T7;!Concanavalin!A;!Micrococcus!lysodeikticus!Cells;!Superoxide!Dismutase;!Creatine!Kinase;!Mucin;!Trypsin;!Cytochrome!C!Oxidase;!Myoglobin;!Trypsin!Inhibitors;!Deoxyribonuclease!I;!NADase!(DPNase);!Trypsinogen;!Deoxyribonuclease!I,!Recombinant,!AOF;!Neonatal!Cardiomyocyte!Isolation!System;!Tyrosine!Decarboxylase;!Deoxyribonuclease!II;!Neuraminidase;!Urease;!Deoxyribonucleic!Acid!and!Related!Products;!Neutral!Protease!(Dispase);!Uricase;!Dextranase;!Nitrate!Reductase;!Xanthine!Oxidase!.!

!

!

!

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Yakult'Pharmaceutical'Industry'Co.,'Ltd.'

http://www.yakult.co.jp/ypi/en/!!

1796!YAHO,KUNITACHI:SHI!

Tokyo!186:8650!!

Japan!

Tel:!+81:42:577:8967 !

Fax:!+81:42:573:1682!



NA!



Enzyme!categories! Food,!brewing,!animal!feed,!life!sciences.!Expression!systems! Aspergillus,,Rhizopus,,Bacillus,,Streptomyces,,Trichoderma,!etc.!Capacity/scale! Bulk.!!In:house!production.!!!Key!People! Chizuka!Kai,!President!Partnerships! NA!Customers! NA!Financial!Health! NA!Catalog!of!Enzymes! ++!Toll!Manufacturing! :!!

Though!known!for!its!yogurt!business,!Yakult!makes!and!sells!food!enzymes!in!this!business!unit.!

Products:!

Cellulases!

Pectinases!

Hemicellulases!

Collagenase!

Proteases!

Glucoamylases!

! ! !!


Alpha:amylases!

Lipase!

Lactase!

!

!

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Zymetech'

www.zymetech.com!!

Kringlan!4:12103!Reykjavík!

Iceland!

Tel:!+354!551!5400!

Fax:!+354!551!5402!



1:10!employees!


Majority!of!revenues!are!enzyme!sales!

Enzyme!categories! Medical,!cosmetical.!Expression!systems! Extraction!from!animal!tissue!(Codfish,!Gadus,morhua)!Capacity/scale! Relatively!small!Key!People! Sigrún!Gísladóttir,!Managing!Director!Partnerships! Andrá,!Iceland!

Enzymatica,!Sweden!Alvogen,!Iceland!and!China!Pure!Icelandic,!UK!FACE!Stockholm,!USA!and!Sweden!ICE!Serum!International!ApS!,!Denmark!

Customers! Sells!through!partners!Financial!Health! NA!Catalog!of!Enzymes! +!Toll!Manufacturing! :!!

From!the!company!website:!“Zymetech!develops!medical!devices!aimed!at!treating!various!medical!indications.!Our!specific!formulations!in!combination!with!purified!marine!proteases!(Penzyme)!have!beneficial!effects!on!the!body!when!applied.”!

Products:!

Cold:active!proteases!(trypsin)!

!

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Zytex'

www.zytex.com!!

Polaris,!6th!floor,!Off.!Marol!Maroshi!Road!

Behind!Sangeet!Plaza,!Marol,!Andheri!(East)!

Mumbai!:!400!059!

India!

Tel:!+91:22:6772!3000!

Fax:!+91:22:6725!3399!



51:200!employees!


Small!

Enzyme!categories! Textiles!Expression!systems! NA!Capacity/scale! Bulk.!!Some!in:house!production.!Key!People! NA!Partnerships! BBI!Enzymes,!U.K.!

Boval!Company,!U.S.A!Dishman!Netherlands!B.V.!(formerly!Solvay)!Giovanni!Bozzetto!S.p.A.,!Italy!Hydro:Thermal!Corp.,!U.S.A!Kem:en:tec,!Denmark!Lallemand!/!Institut!Rosell,!Canada!!Meiji!Co.,!Ltd.,!Japan!Novozymes!A/S,!Denmark!Organo!Technie!S.A.,!France!Toyo!Science!Corp.,!Japan!Unilever,!Netherlands!Worthington!Biochemical!Corporation,!U.S.A!partner!for!Unilever's!Global!Enzyme!Analytical!Lab!for!their!home!care!division!supporting!more!than!65!factories!and!labs!around!the!world!

Customers! In!14!countries.!!Notable!companies!include!Nestle!and!Heinz.!Financial!Health! NA!Catalog!of!Enzymes! +!Toll!Manufacturing! +!

! ! !!


!

Zytex!is!a!manufacturer,!importer,!and!distributor!of!textile!enzymes,!nutraceuticals,!sweetners,!cosmeticals,!baking!aditives,!fertilizers,!pharmaceuticals,!diagnostics,!and!animal!feed!aditives.!!Additionally,!Zytex!has!an!enzyme!analysis!business.!!!

Products:!

Undisclosed!textile!enzymes.!!Likely!cellulases,!amylases,!laccase,!and!catalase.!!

!!!

!

!

!

!

!

!

!

! !

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Distributors'Lists'

Lists!of!distributors!were!compiled!from!lists!that!enzyme!suppliers!provided.!!Some!may!carry!enzymes!as!a!major!part!of!their!offerings,!while!for!others!enzymes!may!represent!only!a!small!part!of!their!ocerall!product!offerings.!Although!the!large!group!of!company!profiles!also!includes!distributors,!those!listed!here!were!deemed!to!be!smaller!in!scale!and!less!focused!on!enzymes.!

!

Distributors'Carrying'Animal'Feed'Enzymes'

!

3'F'Food'&'Feed'S.L.'

Avda!Rey!Juan!Carlos!

I,!98:2°C!

ES:28916!Léganes!

Spain!

Tel:!+34!/!914987466!

Fax:!+34!/!914810544!

Mr.!Juan!Gálvez!del!Hierro!


!

!

A.T.S.'Advanced'Technology'Supplise'A.T.S.'A.S.'

Att:!Can!ÇAGLAYAN!

Turkey!

Tel:!+90!(212)!287!32!50!

Fax:!+90!(212)!287!66!33!

GSM:!+90!(533)!714!45!80!


!

! ! !!


!

A/S'"Dimela'Veta'Latvija",'"Eziši"'

Marupes!pag.!

Rigas!raj.!

LV:2166,!Ezisi!

Latvia!

Tel:!+371!67610001!

Fax:!+371!6780!7830!

Mrs.!Vita!Bude!


!

!

AddBCo'Nutrition'srl'

Massimo!Neri!

via!Carducci,!18!

20123!–!Milano!

Italy!

Tel:!+39:0542!67!02!43!


!

!

Aditmaq'

Vicente!Duque!N73:85!y!Jose!de!la!Rea!!

Quito!

Ecuador!

! ! !!


Tel:!+593!2!2477471!


!

!

Alivet'

Rua!Severino!José!de!Paula,!338!–!Piedade!

Jaboatão!dos!Guararapes!–!PE!

Brazil!

Tel:!+55!81!3342!5422!


!

!

Almoner'Store'Hama'Syria'

Hama!:!Syria!:!AL:Barodiah!Street!

P.O!Box!612!

Hama!

Syria!

Tel:!+96!333210887!

Fax:!+96!333210218!

Dr.!Ahmad!Assar!


!

!

AMMCO'PHARMA'SAÚDE'ANIMAL'LTDA.'

Av.!Pedro!Hereman,!35!!

! ! !!


Centro!!

13165:000!Engenheiro!Coelho!!

Sao!Paulo!SP!

Brazil!

Tel:!+55!19!2105:9462!

!

!

Anmel'Agro'Sdn'Bhd.'

295,!Jalan!2/62!

Bandar!Menjalara!

52200!Kuala!Lumpur!

Malaysia!

Tel:!+60!3!62748067!


!

!

Apsa'Internacional'SA'

Int.!Juan!Lumbreras!1800!!

Gral.!Rodriguez!(CP!1748)!Bs.As.!

Argentina!

Tel:!+54:0237:485:7300!


www.apsanet.com.ar!

'

'

! ! !!


ARTAT'Enterprise''

Al:Hasan!Bin!Ali!Street!Bldg#4!!

Riyadh!11675!

Saudi!Arabia!!

Tel:!+966!1!492!2288!!

Fax:!+966!1!497!2459!!

Emai:[email protected]!!

www.artat.com.sa!!

!

!

Aryadalman'Co.'

Unit!4:No.15,!Meftah!Alley,!

South!Sheikh!Bahaie!St.,!Molasadra!Ave!

IR:11369!Tehran!

Iran!

Tel.:!+98!2188033063!(Ext:109)!

Fax:!+98!2188617296!


!

!

Ascot'International'

veterinary!products!&!animal!health!dept.!

Cité!170!logts!bt1!local!12!

Rouiba!

Algeria!

! ! !!


Tel:!+213!21!81!54!74!


!

!

Auster'Nutrição'Animal'Ltda'

Estrada!Municipal!Cobrasma,!50!

Bairro!Industrial!Delta!

Hortolândia!:!SP,!13.185:000!

Brazil!

Tel:!+55!(19)!3865!9599!


www.austernutri.com.br!

!

!

BELMARC'

Mr.!Leo!Noppe!

30!Bd!Abdellatif!Ben!KADDOUR!

Casablanca!

Morocco!

Tel:!+212!661!332!282!

Fax:!+212!522!279!642!


!

!

Besta'Biotech'Co.'Ltd.'

! ! !!


7Fl.,!No.!54,!Sung!Chiang!Road!

Taipei!10456!

Taiwan!ROC!

Tel:!+886!2!25811628!


!

!

Bill'Barr'and'Company'

8800!Grant!Ave.!

Overland!Park!KS!66212!

USA!

Tel:!+1:800:336:BARR!

Fax:!+1:913:599:0425!

www.billbarr.com!

!

!

Bioferm'CZ,'spol.'s'r.o.'

Banskobystricka!55,!621!00!Brno!

Czech!Republic!

Tel:!+420!541!422!550,!+420!545!247!600!

!

!

BioGem'Ltd'

#238!Color!Hill!Building!

897!Pyungchon:dong!

! ! !!


Dongan:ku,!Anyang:si!

Kyunggi:do!(431:070)!

Korea!!

Tel:!+82!31!4236606!!


!

!

Biosapien'

Al!Quoz!!

1!Dubai,!34206!

United!Arab!Emirates!!

Tel:!+971:50:2927128!

!

!

BIOSMART'COMPANY''

Dr.!Yasser!Abul!Soud!!

1!bank!Eleskan!buildings!

Elmehwar!Elmarkazy!

6th!October!City!

Egypt!!

Tel:!+20110005878!


!

!

BuffaloBWarren'Company'

! ! !!


P.O.!Box!220099!

Charlotte,!North!Carolina,!28222:0099!

USA!

Tel:!+1:704:366:5763!


!

!

C2Mix'Nutrition'Animale'

70,!Angle!Rue!Libourne!et!Boulevard!de!la!Résistance!(6ieme!etage)!

Casablanca!

Morocco!

Tel:!+212!522541111!

Fax:!+212!522541102!

Dr.!Mohamed!Berrada!


!

!

Çelik'Veteriner'Ürünleri'

Danismanlik!Gida!Paz.!!

San.!ve!Tic.!Ltd.,!Sti.!!

Turgut!Reis!Mahallesi!Fatih!Bulvarı!No:328!

Sultanbeyli/Istanbul!

Turkey!

Tel:!+90!/!216!/!598!01!15!

Fax:!+90!/!216!/!598!01!16!

! ! !!



!

!

Central'Agricola'S.A.'de'C.V'

Calzada!Atanasio!Tzul!22:00,!Zona!12!

Empresarial!El!Cortijo!II!

Bodega!120!C.A.!01012!

Guatemala!

Tel:!+502!2327:0340!


!

!

Cerpol'

ul.!Staniewska!16!

63:720!Kozmin!WLKP!!

Poland!

Tel:!+48!62!721!6826!


www.cerpol.net.pl!

!

!

Chr.'Olesen'Nutrition'A/S'

Pieter!Hillebrand!

Jægersborg!Allé!164!

DK:2820!Gentofte!

! ! !!


Denmark!

Tel:!+31!653201198!

Email:!ph@chr:olesen.dk!

!

!

Country'Vet'Wholesaling'Pty'Ltd'

144!Murphy!St.!

Bendigo!VIC!3550!

Australia!

Tel:!+61!/!0!/!1800!426!142!

Fax:!+61!/0!/!03!5442!6119!


!

!

Dakovit'Ltd'

Rákóczi!út!8,!Pf.59!

2943!Bábolna!

Hungary!

Tel:!+36!34!568!470!

Fax:!+36!34!568!479!


!

!

DCL'Nutrition'and'Animal'Health'

6340,!Choquette,!Saint:Hyacinthe!

! ! !!


Canada!

Tel+!+1!450!773!0770!

www.dcli.ca!

!

!

DENBGE'ECZA'DEPOSU'SAN.'ve'TİC.'LTD.'ŞTİ.'

Arabacı!Alanı!Mahallesi!M.!Akif!Ersoy!Caddesi!No:!18/A!

Adapazarı!/!SAKARYA!

Turkey!

Tel:!+90!/!!264!/!279!35!33!!

Fax:!+90!/!264!/!279!35!34!

www.kanatliilaclari.com!

!

!

Disan'

Autopista!Medellin!(Calle!80),!km!1,6!

Costado!Norte!

Bogota!

Colombia!

Tel:!+571!587!7788!


!

!

Egavet'

106,!King!Faisal!Street!

! ! !!


Giza!

Egypt!

Tel:!+202!33!83!7138!


!

!

Eigenmann'and'Veronelli'

Via!Della!Mosa!

6!:!20017!RHO!(MI)!

Italy!

Tel:!+39!02!93539!303!


www.eigver.it!

!

!

El'Badra'International'Company'for'Agri.'Contracting'LTD.'

P.O.!Box!784!Al!Safah!

Mariam!commercial!complex,!office!#!16!

81000!Kuwait!

Kuwait!

Tel:!+965!050513598!

Fax:!+965!051147743/:4739002!

!

!

Encipharm'Ltda'

! ! !!


Av.!Irarrazaval!5185!!

410,!Nunoa!

Santiago!

Chile!

Tel:!+56!2!2263086!


!

!

Farmwealth'Enterprise'Co'Ltd'

No!32,!Alley!22,!Lane!619!

Chung!Hua!Road!

710!Yung!Kang!City!

Tainan!Hsien!

Taiwan!

Tel:!+886!6!2014609!


!

!

Flavor'Corporation'of'Korea'

236:11!JungKok:Dong!

Gwang!Jin:Ku,!Seoul!

KR:143:223!Seoul!

Korea!

Tel:!+82!/!0!/!2!466:9227!

Fax:!+82!/!0!/!2!466:7817!

! ! !!



!

!

Ghazi'Brothers'

Ghazi!House!D:35!

KDA!Scheme!No!1!

Miran!Muhammad!Shah!Road!

Karachi!:!75350!

Pakistan!

Tel:!+9221!111!250!365!


!

!

GlobalVet'

CALLE!MARIO!VALDIVIA!No!180!

URB.!MARANGA!III!ETAPA!!

San!Miguel!

Lima!

Peru!

Tel:!+51!719:0377!


!

!

Hedab'Institution'for'Veterinary'Drugs'

King!Husain!Street!Crossing!

! ! !!


JOR:13110!Jordan:Zarka!

Jordan!

Tel:!+96!/!25!/!3930552!

Fax:!+96!/!25!/!3980030!

Dr.!Nabeel!Al!Luobani!


!

!

Indukern'de'México'

CP.!45019!

Zapopan,!Jalisco!!

México!

Tel:!+52!33!37:77:43:43!

Fax:!+52!33!37:77:43:45!

www.indukern.com.mx!

!

!

Inoza'Industries,'Inc.'

179!Mariano!Ponce!Street!

PH:1400!Caloocan!City,!MetroManila!

Philippines!


!

!

Interpharma'Egypt'Co.'

! ! !!


1!Ellewa!Abd!El:Aziz!Ali,!Al!Mohandes!Tower!

EG:!Zagazig!

Egypt!

Tel:!+20!552!325:801!

Fax:!+20!552!338:946!

Email:!ipc@interpharma:egy.com!

!

!

Inversiones'Toledo'S.A.'

Calzada!Atanasio!Tzul!22:00,!Zona!12!

Empresarial!El!Cortijo!II,!

Bodega!120!C.A.!01012!

Guatemala!

Tel:!+502!2327:0340!


!

!

Invivo'NSA,'SA'

Zona!Industrial!de!Murtede!

3060:372!Murtede!

Portugal!

Tel:!+35!/!1231209900!

Fax:!+35!/!1231209909!

Email:!caguiar@invivo:nsa.pt!

!

! ! !!


!

Julia'Brandt'Plus'

Dostyk!avenue,!house!44,!apartment!69!

KZ:050010!Almaty!

Kazakhstan!

Tel:!+7!727!279!99!71!

Fax:!+7!727!279!71!66!


www.ybp.kz!

!

!

KIMIA'DAROU'MEHR'(PJS)'

Kalantari!Ali!Reza!(DVM)!

General!Manager!

Unit!6,!No.!146,!Gisha!Ave!

Tehran!1447683385!

!Iran!

Tel:!+98!21!88245436!/!37!

Fax:!+98!21!88287753!


!

!

Kubbar'International'Co.'for'Import'&'Export''

Sahoud!Commercial!Complex!

Hawally,!Block!1!

! ! !!


Street!17,!Building!14610,!Fifth!Floor!

Kuwait!

Tel:!+965!22619!404!!


www.kubbarintl.com!

!

!

Lemart'

Paseo!del!Ocaso!249:272!A!

Villas!de!Irapuato!

Irapuato!Gto!36670!

Mexico!!

Tel:!+52!462!623!1333!

[email protected]!

!

!

Lins'Company'(Cong'ty'Hoa'sen)'

7th!Floor,!Block!B,!HDTC!Building!

36!Bui!Thi!Xuan!Street!

Ben!Thanh!Ward,!District!1,!HCMC!

Vietnam!

Tel:!+84!8!39259356!Fax:!+84!8!39259355!

Emails:[email protected],[email protected]!

!

!

! ! !!


Lon'Green'

5F:1,!No.450!Jhengher!South!Rd.!

Chienjen!District.!Kaohsiung!806!

Taiwan!R.O.C.!

Tel:!+886!937!366443!

Fax:!+886!7!537!3386!


!

!

Lotra'Co'

Suite!5,!2nd!Floor!

Bldg!No.10!

8th!St.!Vozara!Ave!

Tehran!15117!

Iran!!

Tel:!+98!21!88704817!/!8!


!

!

M/S'Vet.Pharma'Trading'Company'

Dr!Ahmad!Naseem!Goraya!

New!Steel!Market!Near!Reagent!Cinema!

G.T.!Road!Gujranwala!

Pakistan!

Tel:!+92553258805.3732016!

! ! !!


Emails:[email protected],[email protected]!

!

!

Mazzoleni'Prodotti'Zootecnici'S.P.A.'

Via!dell'Artigianato,!77/81!

24055!Cologno!al!Serio!(BG)!

Italy!

Tel:!+39!354183301!


www.prodotti:zootecnici.it!

!

!

Medical'Products'Ltd.'

Animal!Health!Division!

54,!G.!Gennimata!Ave.!

GR:16562!Athens!

Greece!

Tel:!+30!/!210!/!9647500!

Fax:!+30!/!210!/!9650500!


!

!

Misma'Ltd.'

Mikhail!Smahliuk!

Polyarnaya!str.!31V,!building!1!!

! ! !!


127282!Moscow!

Russia!

Tel:!+7!495!788!53!90!


!

!

Misr'Feed'Additives'

57,!Abd!Al!Hamid!Badawy!St.!

P.O.!Box:!2399!Al!Horia!

EG:11362!Heliopolis!

Egypt!

Tel:!+202!2624!1132!

Fax:!+202!2621!6590!


!

!

Nassim'Al'Shoara'

PO!Box!53571!

Jeddah!21593!

Saudi!Arabia!

Tel:!+966!2!661!3940!


!

!

Neobio'Co.,'Ltd'

! ! !!


Yeongtong:dong,!Yeongtong:gu,!

KR!:!Gyeonggi:Province!443813!

Korea!

Tel:!+82!/!0!/!312020018!

Fax:!+82!/!0!/!312020409!


!

!

Nicoleta'Lux'S.A.'

str.!Calea!Orheiului!59!

MD:2059!Chisinau!

Moldova!

Tel:!+373!22!459247!

Fax:!!+373!22!467533!!


www.nicoleta:lux.md!

!

!

Noack'

Auhofstraße!190!

1130!Vienna!

Austria!!

Tel:!+43:1:877!5455:0!!

Fax:!+43:1:876!5443!!


! ! !!


!

!

Nuevo'S.A.'

Leoforos!Stratigou!N.!Plastira!

34600!:!Nea!Artaki!

Evia!

Greece!

Tel:!+30!222!10!400!81!


!

!

NUTRI'ADVANCE'

Andre:Yves!Bourges!

Parc!technologique!du!Zoopole!

18!A!rue!du!sabot!

F:22440!PLOUFRAGAN!

France!

Tel:!+!33!296!765!486!

Email:!contact_us@nutri:advance.com!

!

!

nutriscan'agro'(bd)'limited'

House#!25/5th!Floor!

Road#!07,Sector!#!04!

Uttara,Dhaka:1230!

! ! !!


Bangladesch!

Tel:!8917972,!01915204797,!01678058839!

Fax:8917972!

!

!

Nutrivet'

Nutrivet!Ic!ve!Dis!Tic.!Ltd.!Sti.!!

Mansuroglu!Mah.!295/2!Sok.!No:1!

B!Blok!Kat:2/219!35010!Bayrakli!

Izmir!

Turkey!

Tel:!+90!232!462!35!25!!


www.nutrivet.com.tr!

!

!

Planet'Health'

94!Rue!Annesrine:Hay!Arraha!(Beauséjour)!

Casablanca!

Morocco!

Tel:!+212522369156!

Fax:!+212522948659!


!

!

! ! !!


PROFEED'

Mr.Cristian!Burlacu!

Bd.!Libertatii!nr.12,!Bl.113,!Sc.1,!Et.7,!Ap.19,!Sector!4,!

040129!Bucuresti!

Romania!

Tel:!+40:21:3173580!

!

!

Promax'International'

2A!Scout!Deguia!corner!Mother!Ignacia!Streets!

Laging!Handa!

1103.Quezon!City!

Metro!Manila!

Philippines!

Tel:!+63!2!4114100!


!

!

PROVENTUS'FARMS'PLUSS'Ltd'

22!Braslas!Str.!

Riga,!LV:1035!

Latvia!

Tel:!+37!126!165!971!


www.proventus.lv!

! ! !!


!

!

Provet'AG'

Gewerbestr!1!

CH:3421!!

Lyssach!

Switzerland!

Tel:!+41!(0)344481129!


www.provet.ch!

!

!

Pulte'GmbH'&'Co.'KG'

Postfach!1313!

83203!Prien/Chiemsee!

Germany!

Tel:!+49!8051!4587!


www.pulte.de!

!

!

PZ'Naše'Selo'

Borisa!Kidrica!59/o!

HR:!31324!Jagodnjak!

Croatia!

! ! !!


!

!

Radin'Feedar'Farda'

unit!3:!#3:!2nd!Alley!

Bucharest!(Ahmad!Ghasir)!St.:!Beheshti!St.!

IR:Tehran!

Iran!

Tel:!+98!21!88!52!58!11!

Fax:!+98!21!88!52!75!43!!!

!

!

Rostal'Resources'Ltd'

PM!News!House!

27,!Acme!Road!

Agidingbi!

Ikeja:Lagos!

Nigeria!

Tel:!+234!1!470!4440!

!

!

Ruth'Consolidated'Industries'Pty'Ltd'

7!to!9!Kent!Road!

Mascot!NSW!2020!

Australia!

Tel:!+61!296670700!

! ! !!



!

!

Safeed'

Volokolamskoe!shosse,!bild.!2!

Волоколамское!шоссе.,!д.!2!

Москва,!125993!

Russia!

Tel:!+7!495!640!39!96!

Email:[email protected];[email protected]!

www.safeed.ru!

!

!

Setna'

C/!Clavo,!1!:!Pol.!Ind.!Santa!Ana!

28522!:!RIVAS!VACIAMADRID!(Madrid)!

Spain!

Tel:!+34!91!666!85!00!


www.setna.com!

!

!

Shahroor'Trading'Co.'

Dabab!Street,!Somatco!Building!1st!floor!

P.O.Box!61439,!Opposit!to!Saudi!Holandi!bank!

! ! !!


SA!11565!Riyadh!

Saudi!Arabia!

Tel:!+966!1!40!444!03!

Fax:!+966!1!40!30!491!


!

!

Techniblend'

2!Duiker!Road!

Melkbosstrand!

7450!Cape!Town!

Western!Cape!

South!Africa!

Tel:!+27218844401!or!+27!828297407!!


www.techniblend.co.za!

!

!

Tecnavic'

Rua!Cleía,!515!–!Barrroso!

Fortaleza!–!CE!

60.863:280!

Brazil!

Tel:!+55!(!85)!3276:1011!

www.tecnavic.com.br!

! ! !!


!

!

UAB'Zalioji'Banga'

Vieversių!382!

sb!Gaižėnėliai,!Jauno!raj.!

Lithuania!


!

!

United'Company'for'Medical'Trade'LTD.'

Main!(Jenin)!Street,!Building!12!

P.O.BX!Tubas!/!500!

Facing!the!Red!Crescent!

Tubas,!West!Bank!

Palestine!

Tel:!+97!0!9!25!73!121!

Fax:!+97!0!9!25!73!121!


!

!

Varluaid'Co'Ltd'

32/2!Soi!Charoenrat!

18!Charoenrat!Road!

Khlongtonsai!

Khlongsan,!Bangkok!10600!

! ! !!


Thailand!

Tel:!+66!2!4375002!


!

!

Vetalmex'

Campo!Grande,!30!4°!A/B!

1700!093!Lisboa!

Portugal!

Tel:!+351!217!815!625!


!

!

Veterquimica'Boliviana'S.R.L.'

Av.!Pirai!nr.!493!

Casilla!3984!

Santa!Cruz!

Bolivia!

Tel:!+591!33520261!


!

!

VETBTRADE'LTD'

158,!Kniaz!Bois!Str.! !

6000!Stara!Zagora!:!Bulgaria! !

! ! !!


Bulgaria!

Tel:!+35!/!942!/!636!858!

Fax:!+35!/!942!/!636!858!

www.my:vet:trade.com!

!

!

Vimar'Gıda'Tarım'Hayvancılık'A.Ş.'

İstanbul!Anadolu!Yakası!Organize!Sanayi!Bölgesi!Aydınlı!Mah.!2.!Sanayi!Cad.!No:16!Tuzla!

Istanbul!

Turkey!

Tel:!+90!/!216!/!593!11!50!!

Fax:!+90!/!216!/!593!11!55!

www.vimar.com.tr!

!

!

Winfarm'

Antonio!Pratas!

Rua!das!Begonias!1!

Herdade!da!Aroeira!

2820:534!Charneca!da!Caparica!

Portugal!

Tel:!+35191!331!7235!


www.winfarm.pt!

!

! ! !!


!

World'Agri'Business'Co.'Ltd.'

542/3168!Sinthorn!Village!Happyland!Rd.!

TH:10240!Bangkapi!Bangkok!

Thailand!

Tel:!+66!2!374!2465!

Fax:!+66!2!375!6159!


!

!

' '

! ! !!


Distributors'Carrying'Life'Science'Enzymes'

!

A2Z'Bio's.r.o.'

Zlatnicka!228!

25073!Jenstejn!

Czech!Republic!

Tel:!+420!777!944!670!


www.pabslabs.com!

!

!

AmpliGene'India'Biotech'Pvt.'Ltd.'

India!

Tel:!+91:79:26560941!!

Tel:!+91:88:66347317!!



www.ampligeneindia.com!

!

!

Asia'Bioscience'Co.,'Ltd.!

1F,No.15,!Lane!162,!Jianmin!Rd!

Beitou!District,!Taipei!City!112!

Taiwan!!

Tel:!+886:2:2827:1197!

! ! !!



www.abscience.com.tw!

!

!

Beijing'Suntrap'Science'&'Technology'Co.,Ltd.'

Room!1222,12F,Huatian!Building!

NO.6!Bei!Xiaomachang,Lianhuachidong!Road!

Haidian!District,Beijing!

China!

Tel:!+86!10!51917556!

Fax:!+86!10!51917557!


en.suntrapbj.com!

!

!

BioClone'Corp.!

4F!Haeryong!B/D,!911:2!Sinjeong4:Dong!

Yangcheun:Gu,!Seoul,!158:857!

South!Korea!

Tel:!+82!2!2690!0058!

Fax:!+82!2!2690!0397!

!

!

BioBConnect'BV!

Begonialaan!3A,!6851!TE!

! ! !!


Huissen!

!The!Netherlands!

Tel:!+31!(0)26!326!4464,!+32!(0)2!503!0348!

Fax:!+31!(0)26!326!4451,!+32!(0)2!503!0327!

Email:!info@bio:connect.nl!

www.bio:connect.nl!

!

!

BIOBKASZTEL'Ltd.'

1118!Budapest!

Kelenhegyi!út!22.!

Hungary!

Tel:!+36:1:3810694!

Fax:!+36:1:3810695!


www.kasztel.com!

!

!

BioTeltec'

Am!Moosbach!6!

74535!Mainhardt!

Germany!

Tel:!+49:7903:91440!


www.bioteltec.com!

! ! !!


!

!

Bond'Biotech,'Inc.'

No!7,!Ln!1,!Yishu!S.!St.,!Longjing!Dist.!

Taichung!City,!434!

Taiwan!

Tel:!+886!4:2652:1202!

Fax:!+886!4:2652:3797!


www.bondbiotech.com.tw!

!

!

Chayon'Laboratories'Inc.'

Korea!

www.chayon.co.kr!

!

!

Cosmo'Bio'Co.,'Ltd.'!

Toyo!Ekimae!Bldg.!2:20,!Toyo!2:chome!!

Koto:ku,!Tokyo,!135:0016!

Japan!!

Tax:!+(81)3:5632:9610!!

Fax:!+(81)3:5632:9619!!


www.cosmobio.co.jp!!

! ! !!


!

!

D.B.A.'ITALIA'S.R.L.'

Via!Umbria!10!

20090!Segrate!(Milano)!

Italy!

Tel:!+39!02!26922300!


www.dbaitalia.it!

!

!

Dyne'Bio'Inc''

B:205,!Woolimlions!ValleyИ!!

146:8!Sangdaewon:dong,!Jungwon:Gu,!Seongnam:Si!!

Gyeonggi:Do,!462:807!!

Korea!

Tel:!+82:02:571:1305!!

Fax:!+82:03:748:8265!!


www.dynebio.co.kr!

!

!

Funakoshi'Co.,'Ltd!

9:7!Hongo!2:Chome,!Bunkyi:ku,!!

Tokyo!113:0033!

! ! !!


Japan!

Tel:!+81:3:5684:1620!

Fax:!+81:3:5684:1775!


www.funakoshi.co.jp!

!

!

Genaxxon'bioscience'GmbH''

Soeflinger!Str.!100!!

89077!Ulm!!

Germany!

Tel:!+49!731!3608!123!!

Fax:!+49!731!3608!962!!


www.genaxxon.com!

!

!

Gene'Technologies''

No:12!,!Kutty!Street!!

Nugambakkam!

Chennai!:!600!034!!

India!

Tel:!44:!43561150!!

Fax!:!44:43561171!!


! ! !!


www.genetechnologies.co.in!

!

!

GeneWorks'Pty'Ltd'

www.geneworks.com.au!

PO!Box!299!

Hindmarsh!SA!5007!

Australia!

Tel:!(08)!8234!2644!

Fax:!(08)!8234!2699!


!

!

Hong'Jing'Co.,'Ltd.!

Address:!5F,No.174,!Sec!1,!Chung:Shan!Rd!

Young:Ho!District,!New!Taipei!City!

Taiwan!!

Tel:!+886:2:3233:8585!


www.hongjing.com.tw!

!

!

InterLabService'Ltd.'

3rd!Proezd!Perova!Polya,!8!building!1!

111123,!Moscow!

! ! !!


Russia!

Tel:!+7!(495)!664!2884!

Fax:!+7!(495)!664!2889!


www.interlabservice.ru!

!

!

M/s.'Bio'Rein'Technologies'Private'Limited!

#2!Third!Street,!Sri!Sakthi!Vijayalakshmi!Nagar!

Velachery!

Chennai:!600!042,!Tamil!Nadu!

India!

Tel:!+(98)!41730824!


www.bioreintechs.com!

!

!

MoreBio'Co.'Ltd.!

Woolim!Lions!Valley,!5ch!A:1505ho,!144:3!

Sangdaewon:dong,!Jungwon:gu!

Seongnam:si,!Gyeonggi:do,!462:120!

South!Korea!

Tel:!+82!2406!2942!

Fax:!+82!2406!2944!


! ! !!


www.morebio.co.kr!

!

!

Neobio'Comercio'de'Produtos'para'Laboratórios,'LTDA''

Rua!Cruz!Pereira,!384!!

CEP!18609:080!!

Botucatu,!SP!!

Brazil!!

Tel:!+55:14:3882:3343!!


!

!

NEW'TEST'Co(NTCo)'For'Scientific'&'Research'Services!

Mustafa!Kamel!

Alexandria,!!

Egypt!

Tel:!+20!3!5444736!


!

!

Noor'ALBSabah'Company'For'Medical,'Laboratory'Instruments'&'Supplies'(NSC)''

P.O.Box:!140757!Albayader!11814!!

Al:Shemisani,!Shaker!Bin!Zeid!Street!!

Building!#28!!

Amman!!

! ! !!


Jordan!!

Tel:!+962!6!5662366!Ext.!1!!

Fax:!+962!6!5662355!!


www.nooralsabahco.com!

(Distributes!in!multiple!countries!in!the!Middle!East)!

!

!

Novazym'Polska's.c.'

www.novazym.com!

ul.!Strzeszyńska!34!budynek!C!

60:479!Poznań!

Poland!

Tel:!+48!61!610!!39!10!

Fax:!+48!61!610!!39!11!


!

!

OOO'AlmaBBion'

Ul.!Vladimira!Nevskogo!59:166!

Voronezh!394005!

Russia!

Tel/fax:!+7(8)473!273:48:28!

Tel:!+7(8)473!273:77:52!


! ! !!


www.almabion.ru!

!

!

Pishgam'Biotech'Company''

Unit!7,!3rd!Floor,!Rose!Building,!!

1669!North!Kargar!St.!

Tehran!1413613148!

Iran!!

Tel:!+98!:!21!:!8801!4393!and!8800!3489!!

Fax:!+98!:!21!:!8801!4418!!

Emails:[email protected],[email protected]!!

www.pishgambc.com!

!

!

Porto'Med!

1!El!Safa!Street,!In!front!of!Wadi!El!Nile!hospital!

El!Kobba!El!Gedeedah!

Cairo!

Egypt!

Tel:!+20!01015553070!

Email:!info@porto:med.com!

www.Porto:Med.com!

!

!

Proquinorte'S.A.''

! ! !!


Alameda!de!Urquijo!87!!

48013!Bilbao!!

Spain!

Tel:!+34!902!999!211!!

Fax:!+34!94!441!68!73!!


www.proquinorte.com!

!

!

Quantum'Biotechnology!

No.90,!Ln.!319,!Dadun!6th!St.,!Nantun!Dist.!

Taichung!City!40864!

Taiwan!(R.O.C.)!

Tel:!+886:4:23863198!

Fax:!+(81)3:5632:9619!

!

!

Quatro'Tecnologìas'Moleculares'para'AND''

Pestalozzi!1204:903!!

Col.!Del!Valle!!

Mexico!!

Tel:!+525559371633!

!

!

ROC'TIBBI'TEKNOLOJI'SAN've'DIS'TIC'LTD!

! ! !!


Bakirko,!Istanbul,!34010!

Turkey!

Tel:!+(90)!2122100320!


www.roc.com.tr!

!

!

Sellex'(S.A.C)'

Rua!Arandu.!205!/!1105!

04562:030!

Sao!Paulo,!SP!

Brazil!

Tel:!(11)5506:4646!!


www.sellex.com!

!

!

ServLab'Co.''

#411!Sehwa!Officetel!!

79:4!Garak:dong!Songpa:gu!Seoul!

Korea!

Tel:!+82:2:449:8787!!

Fax:!+82:2:449:8786!!


www.servlab.co.kr!!

! ! !!


!

!

Shanghai'Boda'Biotech'Co.'Ltd'

Room!1010,!A!Building!No.!411,!Ruijin!er!Road,!Huangpu!District,!200025!

Shanghai!

China!

Tel:!021:64399151,!or!021:64399156!


!

!!

SISRO'MEDICARE!

NO.27,!4S!Square!

Thanthai!Periyar!Nagar!

G.V.Residency!Phase!II!

Sowripalayam!

Coimbatore!:!641!028!

Tamilnadu!

India!

Tel:!+91!422!4206831,!

Tel:!+91!9442200732,!8220001731!


www.sisromedicare.com!

!

!

Synergy'Scientific'Services''

! ! !!


B:2,G:1!Mahalakshmi!Apts!!

City!Link!Road,Adampakkam!!

Chennai:600!088!!

India!

Tel:!044!2245!2787!!

Tel:!9841522118!!


!

!

Team'Medical'&'Scientific'Sdn'Bhd'

404060!Shah!Alam!

Malaysia!

Tel:!603:5122!5108!

Fax:!603:5122!1608!

Email:!info@tms:lab.com!

www.tms:lab.com!

!

!

Trugene'Diagnostics,'Inc.''

8F!74!Song:Te!Rd.!!

Taipei!110!

Taiwan!

Tel:!+886!2!2758:2606!!

Fax:!+886!2!2729:9006!!


! ! !!


!

!Valter'Occhiena'S.r.l.'

Via!Rosta,!7/bis!

10143!Torino!

Italy!

Tel:!+39!(0)11!7716971!

Fax:!+39!(0)11!7761800!


!

!

Vandateb!

Address:!3rd!Floor,!No.!1!

Zagros!Street,!Arjantin!Square!

Tehran!1514934147!

Iran!

Tel:!+982188672685:7!

Fax:!+982188672689!


www.vandateb.com!

!

!

VIRABGENE'Co.''

No!69!Pardis!St.,!North!Shiraz!St.,!Mollasadra!St.!

1991843985!Tehran!

Iran!!

! ! !!


Tel:!+98!21!88611552!!

Email:!Mahdi@vira:gene.com!!

www.bioshop.ir!!

!

!

VWR'International,'LLC''

www.vwr.com!

Radnor!Corporate!Center!!

Building!1,!Suite!200!!

100!Matsonford!Road!!

Radnor,!PA!19087!

USA!

Tel:!+1:800:932:5000!

!

!

WonWon'&'OneStar'Biotechnology'Co.,'Ltd.''

4F,!No.!84,!Gongjhuan!Rd.!!

Taishan!Township!

Taipei!County!24301!!

Taiwan!R.O.C.!!

Tel:!+886:2:2908:9742!!

Fax:!+886:2:2908:9444!!


!

!

Documents

Enzyme Sources Guide final - · PDF fileThe!Enzyme!Sources!Guide!includes!profiles!of!244!companies!that!are!developers,!manufacturers!or! suppliers!of!enzymes;