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7/23/2019 Enzyme Inhibitors Presentation
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ENZYME INHIBITORSAmy Fraser
7/23/2019 Enzyme Inhibitors Presentation
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ENZYME INHIB
•
Enzyme inhibitors are molecules that interere !ith a !or"in# $ecreasin# the rate at !hich an enzyme catalyse$ reaction !o
• The intererence o enzyme inhibitors &re'ent enzymes rom !normally in some !ay%
• There are se'eral ty&es o inhibitors( nons&eci)c( irre'ersible( com&etiti'e an$ non com&etiti'e
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+OM,ETITI-E INHI
•
These !or" in a !ay !hich sto&s the substrate ormin# an enzyme*substra This !or"s because +om&etiti'e Enzyha'e a similar sha&e to that o the sumolecule%
• The inhibitors )t &erectly into the actthe enzyme( but $o not react or chanthey $o not ha'e the same structure
substrate% This $ecreases the rate o e!er substrate molecules can bin$ toenzyme( hence the rate o reaction is
• The +om&etiti'e inhibitors e'entuallyenzyme so thereore they are tem&orsubstrate an$ inhibitors are com&etinin the enzyme( the le'el o inhibition on the concentrations o substrate an
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NON +OM,ETITI-E INHI• Non com&etiti'e inhibitors &re'ents the
ormation o enzyme*product com&le.es% They!or" by sto&&in# the substrate reactin# to orm&ro$uct%
• They usually bin$ to the Allosteric Site% This!ay( the tertiary structure o the enzyme is$istorte$ so the enzyme cannot catalyse areaction%
• As they $o not bin$ to the acti'e site( they $onot com&ete or a &lace there( so they are nota/ecte$ by the concentration o substrate% Mostnon com&etiti'e inhibitors are &ermanent an$irre'ersible an$ $enature the enzymes theybon$ to%
• Others can be non &ermanent are re'ersible(!hich are 'ital or control metabolic unctions inor#anisms% This hel&s the &ro$uct to be ma$e iss&eci)c amounts nee$e$ or the or#anisms%
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ENZYME INHIBITOMETABO0I+ ,O
0ots o &oisons !or" by &re'entin# the action o enzymes that are in'ol'e$ in
&rocesses% This then $isturbs the or#anism as metabolic &rocesses $o not ta"e &lathey shoul$%
E1AM,0ES
Potassium Cyanide
•
Irre'ersible inhibitors o +ytochrome+ O.i$ase enzyme% This enzymeta"es &art I the res&iration reactionsinsi$e cells%
• I inhibite$( AT, cannot be ma$ebecause o.y#en in $ecrease$%
• +auses call to only be able to res&ire
anaerobically( resultin# in a buil$ u&o lactic aci$( !hich can be atal%
Malonate
•
A/ects by bin$in# to the aSuccinate 2ehy$ro#enase
• This causes it to be com&Succinate( !hich is 'ery imres&iration%