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Nanotechnology is a dynamic science producing new materials and products with extraordinary applications in medicine, energy, aeronautics, and the environment. However, there is little regulation governing this science, specifically with regard to personnel and environmental exposure risks.
Nanoparticles exhibit different and varying levels of toxicity, chemical, and physical properties in comparison to their macroscale. For these reasons alone researchers must protect their breathing zones and implement sound risk assessment and risk management strategy by investing in safety containment solutions.
Environmental Health and SafetyOrganizations and universities are now administering nano-specific EHS programs including training and monitoring the work environment which translates to concerns for nano-researcher safety. The specific safety protocols are contingent upon nanomaterial life cycle stages, modifications, and disposal. Containment is necessary because nanotechnology presents vast challenges for environmental monitoring and minimizing harmful contaminants in the laboratory and workplace.
“A fundamental requirement for assessing the potential impacts of new nanomaterials on both human health and environment is the ability to make precise, accurate measurements at the nanoscale in multiple, complex media.” (Strategy For Nanotechnology-Related Environmental, Health, and Safety Research; NNI pp12; 2008)
CUSTOMIZABLE SOLUTIONS
100% of the HEPA filters provided by Flow Sciences are INDIVIDUALLY tested and manufactured under clean room conditions Our 4” pleated media pack was specifically engineered for Flow Sciences volumetric flow rate specifications with strict regards to sub-micron level containment requirements.
The increased surface area of the filter (approx. 238 sq. ft.) coupled with reduced pressure drop in a low flow environment, increases overall particulate capture rates, garnering higher efficiencies of laminar air diffusion. The HEPA filters are contained inside an engineered filter housing and work with low face velocity. Both of these guidelines satisfy NIOSH safety guidelines.
NIOSH has confirmed that HEPA filters work with 99.997% efficiency on nanomaterials down to the 3-20nm range. Flow Sciences’ enclosures have been third-party tested and proven to contain down to less than 300 nanograms per cubic meter.
Integrated powder to chemical nano-process
Custom, multi-phase energy technology production design
Bag-In/Bag-Out 99.99% HEPA filtration
Animated 3-dimensionalrendering with workersshown to scale
DUAL HEPA FILTRATION
NanoSafe is pleased to welcome Dr. Steve Diamond as Vice President of NanoSafe, Inc., Midwest Division. Here, Steve will lead initiatives focused on nanoinformatics, consumer safety with regard to nano-technology-enabled products, and environmental risk assessments of nanomaterials relevant to the military. Stevebrings to NanoSafe a strong background in ecotoxicology, including 20 years of research experience in hazard and risk assessment, as well as a deep understanding of environmental health and safety issues related to nanomaterials.
“Steve is a gi�ed researcher with a unique perspective on the emerging regulatory landscape shaping the commercial use of engineered nano-materials. We’re excited that Steve will be leading our new Midwest Di-vision to help us better serve our clients in the central US and Canada,” says Dr. Matt Hull, founder of NanoSafe.
Previously, Dr. Diamond spent 15 years with the U.S. Environmen-tal Protection Agency’s O�ce of Research and Development (EPA
ORD), and for the last eight years, Steve coordinated the nanomaterial ecotoxicity research e�orts within the EPA ORD. During that time, he coauthored the EPA’s Nanomaterials Research Strategy, represented the United States as a member of the Organization for Economic Cooperation and Development (OECD) Working Party on Manufactured Nanomaterials, and participated in annual reviews of the United States’ research portfolio under the U.S. National Nanotechnology Initiative. Dr. Diamond’s research group within the EPA also published several manuscripts describ-ing the ecotoxicity of nanoscale titanium dioxide, silver, and zinc.
Dr. Diamond brings an experienced perspective and an enthusiasm for the potential economic and societal bene�ts of nanotechnology. He also understands the implications of nanotechnology and the needs of regulators, material scientists, and entrepreneurs who are bringing nanotechnology-enabled products to market. His unique strengths are in the areas of regulatory ecotoxicity testing, and all aspects of nanomaterials photo reactivity.
Says Dr. Diamond, “I came to NanoSafe to help accelerate the process of getting nanotechnology to the marketplace, but doing so in a safe and sustainable manner. NanoSafe is one of the few companies with that focus. Together, we can help clients bring products to market that are safe and sustainable, and that maximize the societal bene�ts of nanotechnology.”
!"#$%&"'()"%!"##$%%&'()*+,&-&./0$1$%230405&6&$7&89):+;;&<)9=;>?@)A&<B4?C6DAB4?C6EF>&G.80&H,>9?@)AI&(?AFJ?:>F9+*&KL&!,)<&":M+A:+;I&DA:N&'O+,?A*I&PQ5&
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RegisteredOctober 31, 2013
TEST DEVICEFS11300 (Model # ETA 363024 ABA) - 3’ Process Workstation with Bag-In/Bag-Out HEPA �ltration, Manufactured by Flow Sciences, Inc. (Leland, NC)
OVERVIEWNanoSafe evaluated the containment of aerosolized nanoparticled by a Flow Sciences, Inc. Process Workstation with Bag-In/Bag-Out, Dual HEPA Filtration (Fig. 1). Testing was adapted from ASHRAE 110-1995, and involved traverse-testing of the workstations ash and HEPA exhaust during werosolation of SiO2 nanoparticles with a geometric mean diameter of 26 nm (Fig. 2). The test provides a useful measure of an enclosure’s ability to contain aerosolized nanomaterials.
RESULTSInternal concentrations of aerosolized SiO2 nanoparticles ranged from 10,000 to 30,000 particles/cm3 (Fig.3). Comparing measurements inside the enclosure and around the enclosure sash opening, containment of aerosolized SiO2 nanoparticles was greater than 99.99% (Table 1). Sampling at the HEPA exhaust �ow showed essentially zero particles and withing the sensitivity of the test, the results indicate no leakage of particles past or through the HEPA �lter. Containment of aerosolized SiO2 nanoparticles by the HEPA exhaust unit was greater than 99.999%.
Copyright © NanoSafe, Inc. 2013. All rights reserved.
DISCLAIMER. Due to the developmental nature of nanotechnology products and associated standards, NanoSafe TestedTM means only that a client’s product has been subjected to the testing criteria. It does not mean that a partiular product is safe for human, animal, or plant interaction nor that the product will satisty governmental standards of safety or compliance. Addicitonal restrictions may apply.
1800 Kraft Dr., Suite 107 • Blacksburg, VA [email protected] • 1.877.SAF.NANO / 540.443.9287Fax: 877.836.1132 • www.NanoSafeInc.com
FIG. 1. Flow Sciecnes, Inc. Process Workstationwith Bag-In/Bag-Out HEPA Filtration.
Sciences,
NanoSafe is pleased to welcome Dr. Steve Diamond as Vice President of NanoSafe, Inc., Midwest Division. Here, Steve will lead initiatives focused on nanoinformatics, consumer safety with regard to nano-technology-enabled products, and environmental risk assessments of nanomaterials relevant to the military. Stevebrings to NanoSafe a strong background in ecotoxicology, including 20 years of research experience in hazard and risk assessment, as well as a deep understanding of environmental health and safety issues related to nanomaterials.
“Steve is a gi�ed researcher with a unique perspective on the emerging regulatory landscape shaping the commercial use of engineered nano-materials. We’re excited that Steve will be leading our new Midwest Di-vision to help us better serve our clients in the central US and Canada,” says Dr. Matt Hull, founder of NanoSafe.
Previously, Dr. Diamond spent 15 years with the U.S. Environmen-tal Protection Agency’s O�ce of Research and Development (EPA
ORD), and for the last eight years, Steve coordinated the nanomaterial ecotoxicity research e�orts within the EPA ORD. During that time, he coauthored the EPA’s Nanomaterials Research Strategy, represented the United States as a member of the Organization for Economic Cooperation and Development (OECD) Working Party on Manufactured Nanomaterials, and participated in annual reviews of the United States’ research portfolio under the U.S. National Nanotechnology Initiative. Dr. Diamond’s research group within the EPA also published several manuscripts describ-ing the ecotoxicity of nanoscale titanium dioxide, silver, and zinc.
Dr. Diamond brings an experienced perspective and an enthusiasm for the potential economic and societal bene�ts of nanotechnology. He also understands the implications of nanotechnology and the needs of regulators, material scientists, and entrepreneurs who are bringing nanotechnology-enabled products to market. His unique strengths are in the areas of regulatory ecotoxicity testing, and all aspects of nanomaterials photo reactivity.
Says Dr. Diamond, “I came to NanoSafe to help accelerate the process of getting nanotechnology to the marketplace, but doing so in a safe and sustainable manner. NanoSafe is one of the few companies with that focus. Together, we can help clients bring products to market that are safe and sustainable, and that maximize the societal bene�ts of nanotechnology.”
!"#$%&"'()"%!"##$%%&'()*+,&-&./0$1$%230405&6&$7&89):+;;&<)9=;>?@)A&<B4?C6DAB4?C6EF>&G.80&H,>9?@)AI&(?AFJ?:>F9+*&KL&!,)<&":M+A:+;I&DA:N&'O+,?A*I&PQ5&
%*'"+'(",&P?A)"?J+& +R?,F?>+*& >S+& :)A>?MAT+A>& )J& ?+9);),MU+*& A?A)V?9@:,+;& KL& ?& !,)<&":M+A:+;I&DA:NI&89):+;;&W)9=;>?@)A&<M>S&4?C6MAB4?C6)F>I&XF?,&G.80&!M,>9?@)A&'!MCNN&/+;@AC&<?;&?*?V>+*&J9)T&0"GY0.&##%6#ZZ[I&?A*& MAR),R+*&>9?R+9;+6>+;@AC&)J&>S+&<)9=;>?@)A&;?;S&?A*&G.80&+\S?F;>&*F9MAC&?+9);),MU?@)A&)J&"ME2&A?A)V?9@:,+;&<M>S& ?& C+)T+>9M:&T+?A& *M?T+>+9& )J& 21& AT& '!MCN& 25N& & /S+& >+;>& V9)RM*+;& ?& F;+JF,&T+?;F9+&)J&?A&+A:,);F9+];&?KM,M>L&>)&:)A>?MA&?+9);),MU+*&A?A)T?>+9M?,;N&
-"#./$#%DA>+9A?,&:)A:+A>9?@)A;&)J&?+9);),MU+*&"ME2&A?A)V?9@:,+;&9?AC+*&J9)T&#%I%%%&>)&$%I%%%&V?9@:,+;B:T$&'!MCN&$5N&&Q)TV?9MAC&T+?;F9+T+A>;& MA;M*+& >S+& +A:,);F9+& ?A*& ?9)FA*& >S+& +A:,);F9+& ;?;S& )V+AMACI& :)A>?MAT+A>& )J& ?+9);),MU+*& "ME2&A?A)V?9@:,+;&<?;&C9+?>+9&>S?A&ZZNZZ^&'/?K,+N& &"?TV,MAC&?>&>S+&G.80&+\S?F;>&_)<&;S)<+*&+;;+A@?,,L&U+9)&V?9@:,+;&?A*& <M>SMA& >S+& ;+A;M@RM>L& )J& >S+& >+;>I& >S+& 9+;F,>;& MA*M:?>+& A)& ,+?=?C+& )J& V?9@:,+;& V?;>& )9& >S9)FCS& >S+& G.80& H,>+9N&&Q)A>?MAT+A>&)J&?+9);),MU+*&"ME2&A?A)V?9@:,+;&KL&>S+&G.80&+\S?F;>&FAM>&<?;&C9+?>+9&>S?A&ZZNZZZ^N&&&&&
0(12%32%0/4,%5)("6)"#7%86)2%9+4)"##%:4+;#$<=46%,($>%?<1@(6A?<1@4.$%BC9D%0(/$+<=462&
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!<I/"%32%5.MM<+O%4N%"6)/4#.+"%K"+N4+M<6)"2&
F4KO+(1>$%T%P<645<N"7%86)2%EL3J2%D//%+(1>$#%+"#"+'"H2%
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RegisteredOctober 31, 2013
TEST DEVICEFS11300 (Model # ETA 363024 ABA) - 3’ Process Workstation with Bag-In/Bag-Out HEPA �ltration, Manufactured by Flow Sciences, Inc. (Leland, NC)
OVERVIEWNanoSafe evaluated the containment of aerosolized nanoparticled by a Flow Sciences, Inc. Process Workstation with Bag-In/Bag-Out, Dual HEPA Filtration (Fig. 1). Testing was adapted from ASHRAE 110-1995, and involved traverse-testing of the workstations ash and HEPA exhaust during werosolation of SiO2 nanoparticles with a geometric mean diameter of 26 nm (Fig. 2). The test provides a useful measure of an enclosure’s ability to contain aerosolized nanomaterials.
RESULTSInternal concentrations of aerosolized SiO2 nanoparticles ranged from 10,000 to 30,000 particles/cm3 (Fig.3). Comparing measurements inside the enclosure and around the enclosure sash opening, containment of aerosolized SiO2 nanoparticles was greater than 99.99% (Table 1). Sampling at the HEPA exhaust �ow showed essentially zero particles and withing the sensitivity of the test, the results indicate no leakage of particles past or through the HEPA �lter. Containment of aerosolized SiO2 nanoparticles by the HEPA exhaust unit was greater than 99.999%.
Copyright © NanoSafe, Inc. 2013. All rights reserved.
DISCLAIMER. Due to the developmental nature of nanotechnology products and associated standards, NanoSafe TestedTM means only that a client’s product has been subjected to the testing criteria. It does not mean that a partiular product is safe for human, animal, or plant interaction nor that the product will satisty governmental standards of safety or compliance. Addicitonal restrictions may apply.
1800 Kraft Dr., Suite 107 • Blacksburg, VA [email protected] • 1.877.SAF.NANO / 540.443.9287Fax: 877.836.1132 • www.NanoSafeInc.com
FIG. 1. Flow Sciecnes, Inc. Process Workstationwith Bag-In/Bag-Out HEPA Filtration.
Nanotechnology is at the forefront of industry developments and scientific advancements in medicine, energy, aeronautics and the environmental field. As with other applications that utilize toxic and sensitive substances, the safe handling of micro- and nano-gram materials depends on an understanding of the risks that laboratories and operators face when working on a scale smaller than 100 parts per 1000 m3.
While the incredibly small scale of nanoprocessing has pushed our understanding of the physics, chemistry, and behavior of these materials, the one constant is that our biggest concern is occupational health and safety.
At the Flow Sciences headquarters, we have a testing laboratory where we confirm the performance of our products against ASHRAE 110 tracer gas standards and perform surrogate powder testing using lactose and naproxen sodium. Our engineers have researched the chemical and physical properties of nanomaterials and their varying levels of toxicity. From those research tests, we have expanded our line of fume hoods to include a series of low-flow containment hoods specifically developed for nanotech applications.
Third-party testing conducted by NanoSafe, Inc.—a leader in managing emerging nanotechnology EHS risks since 2007—has confirmed that our enclosure design effectively contains greater than 99.9% of aerosolized nanoparticles, oftentimes exceeding the in-house safety benchmarks set by our industry partners and customers. Along with our strict engineering controls, these third- party tests by NanoSafe ensure that Flow Sciences enclosures are the safest possible products on the market for use with hazardous and toxic nanomaterials.
Our testing laboratory is only one of the reasons why Flow Sciences is uniquely positioned to offer safety solutions for laboratories at the forefront of nanomaterial application development. Since 1987, we have been leaders in the engineering, designing, and testing of containment enclosures.
• Our patented exhaust systems and vented enclosures reduce vibration and stabilize airflow, increasing the accuracy and safety of your work, both of which are crucial in nanotechnology applications.
• Our nanotech containment enclosures are engineered with a removable plenum and high-speed impeller fan to maintain an ideal air pressure and air speed at the most crucial place in your laboratory: your workspace.
• For added stability, Flow Sciences enclosures also feature extruded anodized aluminum airfoils to smoothly direct airflow across your workspace. As air moves across the enclosure opening, it creates a curtain that forces loose particles to remain contained within the hood and out of the laboratory, away from personnel.
Whether you currently work with nanomaterials or your company is at the outset of nanoprocessing, Flow Sciences is committed to providing your company with solutions that maximize safety without compromising performance.
FLOW SCIENCES IS NOW NANOSAFE TESTED
Flow Sciences custom engineered low-flow containment hoods create a more stable environment than traditional fume hoods, which are less effective when studying powder-based nanomaterial samples.
“...fume hoods were used more as a barrier of protection against harmful vapors rather than nanomaterials. Fume hoods were less likely to be used when the nanomaterial was in a dry powder form. As noted, this may have been due to the potential loss of dry powder form material and the risk of inhalation stemming from air turbulence generated by the fume hood exhaust system.”
- ICONN Nanotech Survey, A Review of Current Practices in the Nanotechnology Industry, November 13, 2006
Application - Lithium
Manifold for Argon and Air
Fire suppression system and LED lighting
Integrated cabinetry
Tempered glass panels with gas shocks
FLAME-TEC POLYPRO
Removable sliding sash
Bag-In/Bag-Out dual HEPA filtration
Drop sink for flat pan scale
Bulk powder cut out
LED lighting
Automatic lift table
Product # shown:CQ3613
72” w x 32” d x 40” h
NANO BULK POWDER
Bag-In/Bag-Out Dual HEPA 99.99% filters
Stainless steel construction
Chemically resistant white phenolic base
Waste chute
Tempered glass #3
CARBON NANOTUBES
Product # shown:CQ351748” w x 30” d x 30” h
10” glove portsHEPA filtration IN, Dual HEPA filtration OUTInternal pass thru with flange connectionFace velocity alarm and stack lightPressure differential gaugeRecessed cavity for scissor liftElectric receptacle mounted on rear wallAcrylic viewing panel
This enclosure was used for the development of a new type of antibody drug conjugate (ADC) for treatment of people with HER2-positive metastatic breast cancer. The development of a cancer medicine that can attach to certain types of cancer cells and deliver potent cytotoxins directly to them, requires Flow Sciences to engineer enclosures that provide the product and personnel protection necessary for research and development where nano particulates are present.
Application: LyoStarIIShown: CQ 3959
Application - Lithium
Manifold for Argon and Air
Fire suppression system and LED lighting
Integrated cabinetry
Tempered glass panels with gas shocks
1.800.849.3429
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Rev. 2
