EnSpectr RAMAN SPECTROMETERS...The method of Raman spectroscopy allows obtaining individual spectral “ﬁngerprints” of materials. It is one of the most accurate approaches for

Portable Raman-luminescent Solutionsby Enhanced Spectrometry, Inc.

EnSpectr RAMAN SPECTROMETERS


www.enspectr.com [email protected]

About Enhanced Spectrometry, Inc.

Why Raman Spectroscopy

Main application fields

Enhanced Spectrometry, Inc. develops and manufactures portable Raman and luminescent spectrometry solutions for a wide range of industries. Our systems are used for advanced materialscharacterization, quality inspection, real-time testing and innovative brand protection based onproprietary technology of materials analysis, recognition and coding of information.

We provide EnSpectr instruments, accessories, professional software, and services for identificationof illicit banned substances, inspection of raw materials, consumer goods, pharmaceutical supplies,gemstones and minerals, water and beverages. EnSpectr spectrometers demonstrate outstandingperformance in real-time analysis of materials providing hyper-sensitive methods for materialscharacterization.

We are proud to provide powerful and cost-efficient EnSpectr spectrometry solutions worlwide.

www.enspectr.com

The method of Raman spectroscopy allows obtaining individual spectral “fingerprints” of materials.It is one of the most accurate approaches for materials characterization at the moment as each”fingerprint“ is inherent and unique for a particular material.

Advantages of the method: • Measurements through transparent and semi-transparent packages • Analysis of liquids, powders, tablets, gels • Accurate results in less than 3 seconds • Qualitative and quantitative analysis • Resolves characteristics of individual DNA molecules • Lightweight, compact, and portable instuments • Full-range in-field use • No sample preparation required • Low cost operation

• Homeland security • Police & Trace Forensic • Mineralogy & Gemology • Raw materials identification • Pharmaceutics & Medical diagnostics • Science & Nanomaterial studies • Semiconductors


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RaPort - Handheld Raman Analyzer

EnSpectr R532 - Raman-luminescence Spectrometer

RamMics M532 - Raman Microscope

Cross-functional low cost spectrometer EnSpectr R532 is the top choice fora number of applications from Gemstone identification to Customs inspections. Wide spectral range (90-6000 cm-1) combined with high spectral resolution(5-8 cm-1) enables spectra of superior quality. EnSpectr R532 may be supplied with a sample stage for better positioningof complicated samples. The standard package includes three attachmentsfor direct measurements, as well as for measurements through semi-transparent plastic packages and glass bottles. The results are receivedimmediately.

An affordable high-performane micro-Raman system enabling transmissionand reflection measurements with high resolution and wide frequency range.RamMics M532 can be supplied with an automated 2D sample stage forRaman mapping, and also can be turned into a compact ultra-low frequency (THz) Raman measurement system that is capable of most complicatedscientific tasks such as, for example,graphene studies.

RamMics M532 allows resolution of particles down to 1 µm; this opens upa wide variety of research opportunities with one compact and affordable Raman instrument.

EnSpectr SERS Substrates

RaPort - Handheld Raman Analyzer is the best option when performanceof a sofisticated laboratory instrument is required in the field conditions. RaPort is the only handheld spectrometer that enables quantitative analysis of active substances even in minimal concentrations by comparisonof the substance and water lines in the solution. Wireless data transmissionis compatible with any Windows/Android smartphone, tablet or PC.

These features make RaPort just the right tool for Gemology, Pharmaceuticals control, Explosive and Narcotic detection, and many others.

EnSpectr SERS Substrates enable identification of separate DNA parts ofonly 2000 nucleotides long, spectral analysis of blood and other biologicalfluids in extremely low quantities with more than two orders of magnitude signal enhancement.

Substrates are supplied as unmountedchips in sets of 10 as a unit of chipspacked in a syrette container.



Gemstone in-field research

RaPort - Handheld Raman Spectrometer

The only high-end handheld instrument on the market combiningportability and superior quality of measurements

Pharmaceutics

• Identification of substances with concentration as low as 1%• Real-time in-situ identification of materials• Bluetooth connectivity • Android/Windows software• Independent power supply and line supply• Database can be extended by user• Weight 2 kg without tablet• Up to 8 hours of off-line operation• Additional battery with external charger• Simple and intuitive user interfaceSecurity

RaPort identifies hazardous materialsand compounds through package: narcotics, drugs, and precoursors;explosives and their plasticizers; toxic solvents and nitro compounds

• Customs & Cargo inspection• Forensic identification• Security check

Laser 532 nmResolution from 6 cm-1

Time per measurement <3 sOperating mode start - 2 min

• 21 CFR 11 software requirements compatibility• Accurate Raw Materials identifications to comply with GMP EU requirements• IQ/ OQ/ PQ documentation

RaPort allows instant non-invasive analysisof substances through plastic blisters, qualitativeanalysis of active substances in ampoules(even in minimal concentrations) by comparisonof the substance spectral features and water lines.

• Geology and Mineralogy• Archeology• Gemstone identification

RaPort perfectly acquires mineral spectrum withhigh quality guarantying high level protection ofgemstones. Jewels' spectra are measured directlyin any type of jewelry set. RaPort is the only portable Raman spectrometer that analyzes sapphires, rubiesand emeralds due to the unique technology of redluminescence removal or subtraction.



EnSpectr L405 - Luminescence Analyzer

EnSpectr luminescence analyzer works with a 405 nm laser diode andsets new records at blue-violet wavelengths with the spectralresolution of 0.5 nm and the spectral range of 455-760 nm.

EnSpectr L405 can be used in various applications e.g. medical diagnostics of human tissues (cancermonitoring, dental caries treatment), bacteria investigation, food control (analysis of meat and waterfreshness), characterization of semiconductors, etc. L405 module may be added to microscopeRamMics M532 or RaPort Handheld Raman Spectrometer upon request.

EnSpectr Micro Kit turns your standard microscope into a full-rangemicro Raman system.

The package includes: EnSpectr R532 Scientific Edition withspecialized connector to standard microscope port, reflectionmicroscopy tool, digital 3 Mp camera, proprietary EnSpectr Prosoftware with extended functionality for spectral measurementsand recognition. Being a professional cost-effective solution EnSpectrMicroKit can be supplied with an ultra-low frequency Raman spectrometer for advanced research.

EnSpectr Spectral Marker

EnSpectr Spectral Marker is a highly efficient counter measure for goodscounterfeiting.

The original product is marked with a special chemical substances in ultralowdoses (down to 10-6 or less), so that afterwards the product can be instantlyanalyzed to identify fake or counterfeit.

EnSpectr Spectral Marker is certified as being harmless, edible and notaffecting the consumer properties of the base substances.

EnSpectr MicroKit

EnSpectr Water

EnSpectr Water is a fully automatic complex for water disinfectioncontrol. It is realized by means of maintaining required concentrationof highly profitable disinfectant PHMG.

The measurement technique is fast and simple, with the accuracybetter than 10% across the range of 10-8 (0.01 ppm) - 10-5 (10 ppm). As it is vitally important to keep a safe level of PHMG in water toprevent harmful effects of more concentrated substance, EnSpectrWater guarantees the accuracy of measurements and keeps you safe.



The presense of pseudomonades is as infection indicator: intensive bacteria growth on food products is followed by the evolution of fluorescent pigment that can be detected by RaPort Bio.

RaPort Bio - Luminescence Analyzer for Meat Quality Control RaPort Bio instantly detects the fluorescent pigment ofPseudomonas aeruginosa.

Rapid spectral analysis allows determination of meatstorage time with up to one hour accuracy.

Fresh beef

Fresh salted pork Fresh salted pork: 4 hours storage at 20°C

Fresh beef: no bacteria detected

Reference area for 48 hours fresh meat torage of at 20°C

Reference area for 90hours of fresh meatstorage at 20°C

Specifications:

• Accurate in-situ food analysis • No mechanical contact• Measurement time– 1 second• 10 hours of off-line operation• Bluetooth or USB data transmission right to your smartphone/ laptop • Simple and reliable to use• Windows/Android OS



EnSpectr MixSplitter analyses each grain of the mixture whichimproves the limit of detection of residual contaminant andensures more accurate identification of component concentration.

MixSplitter is equipped with an XY-axis automated translationstage for sample scanning perpendicularly to the microscopeobjective's optical axis.

Professional software ensures real-time spectra measurements in automatic mode synchronized with step-by-step samplescanning, unknown substance identification algorithm, andoutput of the data statistical analysis.

EnSpectr MixSplitter - Rapid Qualitative and Quantitative Analysis of Heterogeneous Powders

~100 – 4000 сm-1 532 nm, power ~1-30 mW40x5 microns>0.5 microns2-axis40 000~0.5% for 20 min~0.1% for 100 min

No limitsOrganic / inorganic

Spectral rangeLaserMicroscope objectivesSpatial resolutionDistinct particle size limitAutomatic positionerMaximum number of stepsDetection limit in a powder mixture (during whole analysis)Number of mixture compoundReference spectra database

• Trace Forensics• Narcotics ID• Homeland Security• Pharmaceuticals• Chemical Processes• Food Additives Control

MixSplitter

Heroin

Sugar

Steps

1 2 3 4

Additives detection down to 0.1 %

Scanning results presentcharacteristics of mixturecompounds and theirpercentage ratio

Results of chromatomass analysisobtained in 20 minutes

Applications



Accurate examination of molecule chemical distribution within the mixture. Example: synthesized diamondinclusions in seemingly homogeneous carbon powder.

Example: apatite in garnet. Inclusions help to reveal hidden properties of the gem e.g. its origin.

RamMics M532 Raman Microscope integrates opportunitiesof Raman Analyzer EnSpectr R532 Scientific Edition andOlympus CX-41 microscope adapted for both transmission and reflection measurements.

Wide functionality of RamMics M532 allows distinguishingparticles of 2-3 µm in size and differentiation of them bychemical and physical properties, which opens multipleresearch opportunities with one affordable Raman instrument.

Applications

• Pharmaceuticals• Forensic Analysis• Geology & Mineralogy• Gemology• Chemical Processes• Medical Diagnosis• Semiconductors• Food & Agriculture

Spectral range: 90 - 4000 cm-1

Spectral resolution: 4-6 cm-1

Spatial resolution: 1 µm 3 Mp camera2D scanning sample stageAutomatic recognitionProfessional software10x, 20х, 40х (Plan-C),MPLN50x objectives includedPortable leak & shockproof case

Thin films Raman studies

Gem inclusion analysis

Raman 2D Mapping

RamMics M532 - Raman-luminescent microscope Transmission & reflection measurements

Example: graphene. The Nobel Prize in Physics2010 was awarded "for groundbreaking experimentsregarding the two-dimensional material graphene".



EnSpectr SERS Substrates

• Medicine: biological fluids, bacteria, viruses examination • Trace Forensics• Biohazard monitoring

Applications

6x6x0.5ø5Liquid drop deposition-evaporation / Liquid drop spin coatingImmersion / Vapour phase deposition

λ 450 - 550 nm / Spot size - arbitrary / Power density < 5000 W/cm2

>10⁵ - for neutral substances>10⁷ - for resonant Raman analytes and substances exhibitingaffinity to silver

<10%

70 h after opening the package

Size (mm)Active area (mm)Sampling methods

Laser excitation

Enhancement factor relative toa non-enhancing surface

Relative standard deviationin signal

Twofold reduction of theenhancement factorat open air

Task: identi�cation of substances in ultra-low quantitiesSolution: nanostructured SERS substrates

Analysis of various chemical compoundsin extremely low quantities (one DNA molecule)Enhancement Factor – over 107



Ultra-Low Frequency Raman (THz) Spectrometers and Microscopes Innovative compact Raman-ThZ instruments

Spectral range:(-780) - (-7) cm-1 /anti-Stokes/7 - 3850 cm-1 /Stokes/Spectral resolution: 5-6 cm-1

Spatial resolution: 1 µm 3 Mp camera2D scanning sample stageAutomatic recognitionProfessional software10x, 20х, 40х (Plan-C),MPLN50x objectives includedPortable leak & shockproof case

EnSpectr MicroKit is a complete add-onmicroscope solution that enables highly precisemeasurements of Raman spectralcharacteristics.

EnSpectr MicroKit package includes:• EnSpectr spectrometer• Reflection microscopy tool• 3 Mp camera• EnSpectr Pro software

• On-line technical support by authorized distributors and the Company

EnSpectr MicroKit - Upgrade your microscope to a full-range Raman (or ThZ) system

Applications

EnSpectr ultra-low frequency Raman systems were thefirst affordable portable instruments of its kind on themarket worldwide. Use EnSpectr systems to conductmeasurements both in standard Raman spectralrange (200-3850 cm-1) and Terahertz range (7-200 cm-1).

• Advanced analysis of carbon nanotubes for checking sample quality and composition• Detection of additional folded acoustic modes of multilayer superlattice structures in advanced semiconductor devices• Research of heavy atom vibrations in compounds• Analysis of low wavenumber shear modes and lattice modes



Removable charging battery 8 hours of continuous operation

Analysis of pure substancesand mixtures

Quick impurity detection in ultra-low doses

Measurementsthrough transparentand colored glass,plastic packages

532 nm laser is used in most bigRaman systems: explosives like TNTshow substantially less luminescencewith 532 nm laser systems thanwith 785 nm ones

No in-built screen: longer batterylife & no worries in-filed

Compatible with Windows/ Androidsmartphone, tablet or laptopData transfer is quick and easy

EnSpectr spectrometers are unique Raman-luminescent analyzers. Spectral range : 90-6000 cm-1 (540-790 nm or more)

Wide spectral range is highly important as luminescence lines may often be narrow and informative.

Our specialized software with multiple modes of spectra recognition based on proprietary algorithmsallows us to improve the quality of spectra recognition and to solve a number of specific issues e.g.detection of narrow and weak Raman lines on the background of a substrate, rapid identificationof a substance in multicomponent mixtures, and broad luminescence lines recognition.

FEATURES AND ADVANTAGES

Most portable devices available on the market have a range of 250-2000 cm-1 ; this excludes the linesof essential materials and structures that lie outside of this range e.g. water (3400-3600 cm-1).

Spectral resolution of 4-6 cm-1 allows analysis of complex Raman spectra and provides excellentquality of sample recognition.

At 532 nm luminescence lines fade by contrast to the Raman ones.Besides, the luminescence is easily removed by the EnSpectr software.

The unique shutter technology allows measurement of objects with ultra-high red area luminescence e.g. rubies, sapphires etc.

ENSPECTR WORLDWIDE DISTRIBUTORS

EnSpectr RAMAN SPECTROMETERSby Enhanced Spectrometry, Inc

560 South Winchester Blvd #500 San Jose, CA 95128, USAwww.EnSpectr.com | [email protected] | Tel.: (+1)650-241-1440

AustraliaWarsash Scientific Pty Ltdwww.warsash.com.auTel.: +61 2 9319 0122

ChinaBeijing Top Unistar Science& Technology Co., LTD.www.top-unistar.comTel.: 0086-010-62530444

Czech RepublicRMIwww.rmi.czTel.: 466 921 404

DenmarkKC Labtechwww.kc-labtech.comTel.: +45 2870 9080

GermanyScientific Instrumentswww.si-gmbh.deTel.: +49 (0)8105 - 77940

IndiaInstruments IndiaE-Mail: [email protected].: +91 11 9818 136 746

IndiaKapri Corpwww.kapricorp.inTel.: +91 22 66924209

IndonesiaPT. Pacific Aman Gardawww.pacificamangarda.comTel.: 021-7226036

Russian FederationInSpectr LLC.www.enspectr.com/ruTel.: + 7 (49652) 240 44

SlovakiaRMIwww.rmi.czTel.: 466 921 404

Your EnSpectr manager: e-mail:

IsraelWise-Tech Ltd.www.wise-t.co.ilTel.: +972-3-9106060

JapanKLV Co.Ltdwww.klv.co.jpTel.: +81-3-3258-1238

JapanLUCIR Inc.www.lucir.co.jpTel.: +81 (29) 848 3030

Moldova, RomaniaApel Laserwww.apellaser.roTel.: 00 40 213170910

South AfricaWirsam Scientificwww.wirsam.comTel.: +27 (0) 11 482 1060

TaiwanSunWay Scientific Corp.www.sun-way.com.twTel.: +886 2-2771-8337

United KingdomLOT-QuantumDesign Ltdwww.lot-qd.co.ukTel.: 01372 378822

United StatesOptiGrate Corp.www.optigrate.comTel.: 407-542-7704

Documents

EnSpectr RAMAN SPECTROMETERS...The method of Raman spectroscopy allows obtaining individual spectral “ﬁngerprints” of materials. It is one of the most accurate approaches for