often at the level of the cricopharyngeus. The objective of thisstudy is to assess the feasibility of endoscopic CO2 lasercricopharyngeal myotomy and/or stricture ablation in the set-ting of prior radiotherapy.METHOD: A retrospective review of patients who underwentendoscopic CO2 laser cricopharyngeal myotomy with or with-out stricture ablation for dysphagia after radiation for squa-mous cell carcinoma of the head and neck (SCCHN). Pre andpostoperative barium swallow studies were performed as wellas formal speech pathology evaluation before and after sur-gery. Outcomes and complication rates were examined.RESULTS: Between July 2008 and November 2009, 9 pa-tients with prior treatment for SCCHN with chemoradiationwere identified with dysphagia as a result of cricopharyngealstenosis/stricture by barium swallow. Endoscopic CO2 lasercricopharyngeal was performed on all patients. No complica-tions were observed. Documented resolution of stenosis wasobserved on barium swallow in 8 of 9 patients, with partialresolution in the other patient. Swallowing improved fromliquid diet to a regular diet in 4 patients, and from gastrostomytube dependence to a soft diet in three patients, including thepatient with partial resolution. Additional dilation was neces-sary only in the one patient with incomplete stricture ablation,who declined additional endoscopic surgery.CONCLUSION: Endoscopic CO2 cricopharyngeal myotomycan be performed safely in the setting of prior chemoradiation,with significant improvement in swallowing in select patients.Indications and technical considerations will be discussed.

Endoscopic KTP532 Laser Resection of Early

Laryngeal Cancer

Balakrishnan Ramaswamy, MS, DNB (presenter);Produl Hazarika

OBJECTIVE: To assess the efficacy of KTP-532 laser assistedmicro-endoscopic laryngeal surgery in early laryngeal malig-nancies.METHOD: This is a retrospective study of 83 patients withearly laryngeal cancer diagnosed clinically (T1 & T2) whounderwent KTP-532 laser assisted micro-endoscopic laryngealsurgery in our institute which is a tertiary hospital. This pre-liminary study was conducted between 2000 and 2008 withminimum follow up period of 12 months.RESULTS: 80 were males and 59% were in the 50-69 yearsage group. 17 patients (21%) had supraglottic and 65 patients(78%) had glottic tumors. 46% of patients had T1 lesions andrest 54% had T2 lesions. All patients underwent laser assistedexcision of the tumor under frozen/ paraffin section biopsycontrol. 8 patients of supraglottic tumor (N1- 3 cases, N2- 1case, N0- 4 cases) underwent neck dissection also. 11 caseswith positive margins / metastatic node were sent for radio-therapy. 5 had recurrence (3 underwent total laryngectomy andtwo underwent radiotherapy). Disease control rate of the laser

surgery alone was 93%. Only one patient died of distant me-tastasis. All the patients had acceptable voice quality and only2 cases had transient aspiration.CONCLUSION: KTP-532 laser assisted micro-endoscopiclaryngeal surgery is a viable and superior method of treatingearly laryngeal malignancies with good disease control rateand less morbidity.

Epidemiology of Head and Neck Sebaceous

Carcinoma

Nitin Pagedar, MD (presenter)

OBJECTIVE: Sebaceous carcinoma (SC) is a rare tumor ofepithelium of cutaneous sebaceous glands. We sought to de-scribe the epidemiology of these tumors using the NCI-SEERdatabase.METHOD: Data from the SEER database was retrospectivelycollected for sebaceous carcinoma from 1973-2006. We com-pared eyelid, extra-ocular head and neck, and non-head andneck subsites. Information on histologic grade, stage of diseaseand information on survival was gathered.RESULTS: A total of 825 SCs were diagnosed during thetime period: 362 (43.9%) in the eyelid, 303 (36.7%) in theextraocular head and neck skin and 160 (19.4%) in non-headand neck skin. There was an increase in incidence of sebaceouscarcinoma over the study period. Information on histologicgrade was available for 237 tumors. Eyelid SCs had higherhistologic grade compared with tumors in other extra-ocularsites (p�0.001). Ocular SCs had a higher incidence of invasivedisease at presentation (16.0%) compared with extra-ocularH&N sites (8.5%), p�0.03. Information on neck disease wasavailable for 61 tumors, there was a high incidence of N�disease in poorly differentiated ocular SCs (26.5%). Five-yearrelative survival of ocular SCs was 97.9%, whereas for ex-traocular it was 94.4%, not significantly different.CONCLUSION: Poorly differentiated SCs have high inci-dence of advanced disease. Eyelid SCs are of higher histologicgrade, and behave more aggressively than non-eyelid tumors.Relative survival for sebaceous carcinoma is good.

Epigallocatechin-3-Gallate Inhibits Oral Cancer

Progression

Yoon Woo Koh, MD, PhD (presenter); Hyun JunHong, MD; Jae Wook Kim, MD; Eun Chang Choi,MD, PhD; Chul Ho Kim, MD, PhD

OBJECTIVE: Hepatocyte growth factor (HGF) and c-Methave recently attracted a great deal of attention as prognosticindicators of patient outcome and are important in the controlof tumor growth and invasion. Epigallocatechin-3-gallate(EGCG) has been shown to modulate multiple signal pathwaysin a manner that controls the unwanted proliferation and inva-sion of cells, thereby imparting cancer chemopreventive and

P184 Otolaryngology-Head and Neck Surgery, Vol 143, No 2S2, August 2010