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Endocrine System
Chapter 11
MajorHormone Secreting Structure
s
General Information Integrates and coordinates activities of
body cells. Maintains homeostasis by regulating:
1. metabolism and energy balance
2. water, electrolyte & nutrient balance
3. reproduction, growth and development
4. mobilization of body against stressors
Hormones are secreted into interstitial fluid diffusing into blood or lymph fluid.
Hormones act upon specific target cells.
Regulation & Communication Two systems for regulation:
endocrine system ductless glandular epithelium
secrete hormones directly into blood chemical travels to target tissue target cells have receptor proteins slow, long-lasting response
nervous system system of neurons
transmits “electrical” signal & release neurotransmitters to target tissue
fast, short-lasting response
Regulation by chemical messengers
axon
endocrine gland
receptor proteins
target cell
Neurotransmitters released by neurons Hormones release by endocrine glands
receptor proteins
hormone carried by blood
neurotransmitter
Lock & Keysystem
Classes of Hormones Protein-based hormones
polypeptides small proteins: insulin, ADH
glycoproteins large proteins + carbohydrate: FSH, LH
amines modified amino acids: epinephrine, melatonin
Lipid-based hormones steroids
modified cholesterol: sex hormones, aldosterone
insulin
Steroid HormonesSteroid Hormones Lipid soluble
(hydrophobic) Synthesized from
cholesterol Transported by a protein
in bloodstream. Diffuses inside, binds
with DNA to transcribe gene.
Full effect could be minutes to days.
Animation – Intracellular Receptor Model
Protein HormonesProtein Hormones Water soluble (hydrophilic) Binds to receptors on target
cell membranes. No diffusion!
Causes second messengers (cAMP) to be activated inside cell.
Cascading effect: a single molecule can activate hundreds of second messengers each which activates thousands of reactions.
Rapid response Multiplier effect!
Animation – Second Messenger cAMP
AP Biology
Benefits of a 2° messenger system
Amplification!
signal
receptor proteinActivated adenylyl cyclase
amplification
amplification
amplification
amplification
GTP G protein
product
enzyme
protein kinase
cAMP
Not yetactivated
1
2
4
35
6
7
FAST response!
amplification
Cascade multiplier!
Specificity of Hormones
• Target cells only respond to a specific hormone by having a unique receptor just for that hormone.
• EX: Insulin receptors only respond to insulin not thyroxine.
Control of Hormone Secretion
Hormone RegulationHormone Regulation Hormone secretion is controlled by:
1. Neural stimuli 2. Humoral stimuli (blood chemistry)3. Hormonal stimuli
Process used to regulate:FEEDBACK LOOPS!
Homeostasis of Blood Glucose
liver
pancreas
liver
Regulation of Blood Sugar
blood sugar level(90mg/100ml)
insulin
body cells takeup sugar
from blood
liver storesglycogen
reducesappetite
glucagon
pancreas
liver releasesglucose
triggershunger
high
low
FeedbackEndocrine System Control
islets of Langerhans beta islet cells
islets of Langerhansalpha islet cells
Gland A secretes a hormone that stimulates gland B to increase secretion of another hormone. The hormone from gland B alters its target cells and inhibits activity of gland A.
Target CellsTarget Cells Responsiveness can depend on:
1. Hormone concentration2. Amount of receptors a. up-regulation (increasing # of
receptors)
b. down-regulation (decreasing # of receptors)
3. Influence of other hormonesSynergistic effect vs. Antagonistic effect
(Glucagon + epinephrine) (Insulin and Glucagon)
Nervous & Endocrine systems linked Hypothalamus = “master nerve control center”
nervous system receives information from nerves around body
about internal conditions releasing hormones: regulates release of hormones
from pituitary
Pituitary gland = “master gland” endocrine system secretes broad range
of “tropic” hormones regulating other glands in body
hypothalamus
pituitary
posterior
anterior
Hormone DisordersHormone Disorders Most involve the HYPOSECRETION
or HYPERSECRETION of a hormone.
Hypersecretion most likely due to a tumor on the gland.
Few cases involve faulty hormone receptors or reduction of receptors.
Grave’s DiseaseHyperthyroidism
Symptoms:
Intolerance to heat
Heart palpitations
Sensitivity to light
Weight loss
Appetite increase
Easily agitated
Protruding eyes
Hypothyroidism or MyxedemaEarly symptoms:Being more sensitive to cold Constipation Depression Fatigue or feeling slowed down Heavier menstrual periods Joint or muscle pain Paleness or dry skin Thin, brittle hair or fingernails Weakness Weight gain (unintentional)
Late symptoms, if left untreated:Decreased taste and smell Hoarseness Puffy face, hands, and feet Slow speech Thickening of the skin Thinning of eyebrows
Cretinism – lack of thyroxine during fetal life
AP Biology
GoiterIodine deficiency causes thyroid to enlarge as it tries to produce thyroxine
thyroxines
tyrosine+
iodine ✗✗
+
Acromegaly
hypersecretion of GH during adulthood, usually a pituitary tumor.
Only certain bony regions in face, feet and hands are affected by excessive bone deposition.
GigantismHypersecretion of GH during childhoodIf left untreated, acromegaly will occur.
Pituitary Dwarfism
Hyposecretion of GH, can be corrected by giving GH hormone
Must be diagnosed before growth plates have closed.
Can be tumor related
Gigantism vs. Dwarfism
Adrenal Gland DisordersCushing’s
Excess Cortisol Weight gain Rounded moon face Fatty hump on back Fatigue
Addison’s Hyposecretion of
glucocorticoids and mineralcorticoids
Mouth lesions Hypoglycemia Strange skin
pigmentation Salt craving
DiabetesD. Insipidus
“tasteless” Hyposecretion of
ADH Extreme thirst Dehydration Excessive
urination
D. Mellitus “Sweet tasting” Hyposecretion of
insulin (type 1) Blood glucose build
up Weight loss Excessive urination Sweet smelling
breath
Adipose and Leptin Leptin is hormone that
causes you to feel full. Obesity may be due to
no leptin or not enough or hypothalamus becomes leptin resistant.