Endocrine Disrupting Chemicals

7/18/2019 Endocrine Disrupting Chemicals

1/19

Exploring theEfects oMultiple EDCExposure

Katharyn Sel

RU Biology

Ecophysiology Lab


2/19

What are EDCs!

En"ocrine DisruptingChe#icals $EDCs%& areen'iron#ental che#icalsthat interere (ith thenor#al unction o the

en"ocrine syste#) *he En"ocrine Syste#

controls bo"y unctionsby releasing hor#ones

into the bloo" strea#)

http+,,li'ingbetter)#e,(p&content,uploa"s,-./0,//,en"ocrine&syste#)png


3/19

EDCs #i#ic these hor#ones1 by bin"ing to thereceptor sites on target cells)

http+,,((()cancer)go',2ublishe"Content,3#ages,cancertopics,un"erstan"ingcancer,estrogenreceptors,sli"e4)gi
http://www.cancer.gov/PublishedContent/Images/cancertopics/understandingcancer/estrogenreceptors/slide5.gifhttp://www.cancer.gov/PublishedContent/Images/cancertopics/understandingcancer/estrogenreceptors/slide5.gifhttp://www.cancer.gov/PublishedContent/Images/cancertopics/understandingcancer/estrogenreceptors/slide5.gifhttp://www.cancer.gov/PublishedContent/Images/cancertopics/understandingcancer/estrogenreceptors/slide5.gif


4/19

EDCs are able to bin" to 6or#one ReceptorSites "ue to a Si#ilar Molecular Structure

http+,,-)bp)blogspot)co#,&L3Mp7D-6U8o,*s#79s3&R:3,;;;;;;;;Bh?as"@A7,s-..,B2;'sEstra"iol)png

http+,,che#istry)about)co#,o",oo"coo=ingche#istry,a,bha&bht&preser'ati'es)ht#

http+,,#arshanunley#")(or"press)co#,-.//,.0,.7,estrogen&a&hor#oneuchaligne",

Butylated hydroxyanisole (BHA)


5/19

EDCs are co##only oun" inDiet

Drin=ing (ater Cleaning Che#icals6ygiene an" Beauty pro"ucts

http+,,(il=esbarrerecycles)co#,i#g,cans9ars)pg

http+,,((()bran"channel)co#,eatures

9efect)asp!p9i"FAA

http+,,((()(o#enshealth#ag)co#,Gles,i#ages,.>.A&aci"&test&.H>.)pghttp+,,((()eating"isor"erpro)co#,(p&content,uploa"s,-./-,//,oo"a""iti'es)pg


6/19

EDCs 3#pact 6u#an 6ealth


7/19

We are Born 2re&pollute" 3n a stu"y "one by the

En'iron#ental Wor=ingIroupJ u#bilical cor"bloo" (as ta=en an"analye")

-A@ "iferent che#icals(ere oun"J an" as laterstate" by the researchers1ha" they teste" or ane'en broa"er array they(oul" ha'e "etecte"#ore $6oulihan%

oulihan ?1 et al $-..4% Bo"y Bur"en+ *he 2ollution in e(borns) *he En'iron#ental Wor=ing Iroup) http+,,((()e(g)org,research,bo"y&bur"en&

ollution&ne(borns

http+,,((()theutureohealthno()co#,(p&content,uploa"s,-./0,//,baby&in&(o#b)peg


8/19

Who is #onitoring EDC exposure!*he go'ern#ent $E2;% has

loose interpretations on(hat is consi"ere" saeNle'els o these che#icals)

Most o the EDCS ha'ebeen teste" singularly ona #o"el organis#

*his #etho" o testing isnot ecologically rele'antas organis#s are expose"

to #ultiple EDCse'ery"ay throughche#icals in theirsurroun"ings an" their"iet)

& &


9/19

*6E B3I UES*3O+What efects "o #ultiple EDC exposure ha'e

on an organis#!

Ioal+ Explore possible synergistic efects oco##on estrogen #i#ic=ing EDCs1 (hen

co#bine" at ecologically rele'ant le'els $plausibleexposure rates%

http+,,((()'isualphotos)co#,photo,-x0>/-7/A,t(o9Pas=s9(ith9blue9an"9yello(9solutions9/A./0H0)pg


10/19

Estrogenic EDCs Estrogen has broa" efects on both the #ale an"

e#ale bo"y1 ranging ro# repro"uction to bonegro(th)

Estrogen helps to regulate the serotonin syste#1(hich aQicts aggression1 cogniti'e unction1 an"

#oo" $Iayathri C1 -.//%)6igh a#ounts o external estrogen an" estrogen&

li=e che#icals ha'e been lin=e" toJ early puberty1"ecrease" sper# count1 sexual "ysunction1

higher re:uencies o repro"ucti'e cancers$?obling %1 an" e#iniation o so#e species intheir natural en'iron#ent) $Molina%

?obling S1 et al$/HH4% ; 'ariety o en 'iron#entally persistent ch e#icals1 inclu"ing so#e p hthalate plasticiers1 are (ea=ly estrogenic) E n'iron

6ealth 2erspect /.0+ 4A- 4A@) 2MC ree articleT

2ubMe"T

4)Molina ;1 et al $-.//% En"rocrine&acti'e co#poun" e'aluation+ ualitati'e an" :uantitati'e histo#orphological assess#ent o ebraGsh gona"s

Iayathri C 1$-.//% 8EBR;3S6 ;S ; MODEL *O S*UD< *6E EUROEDOCR3ES


11/19

B2; Bisphenol&; $B2;% B2; leaches into the oo" ro# the

protecti'e inner coating o canne" oo"s an"other oo" storage an" oo" use pro"ucts1inclu"ing #any storage containers #a"e o

polycarbonates)

UunU

actW

B2;(aso

rigina

lly

use"in

estrogen

replac

e#en

t

therap

yfor

(o#e

n

http+,,((()greenerpac=age)co#,sites,"eault,Gles,bpa-)pg

http+,,c"n4)triplepun"it)c

o#,(p&content,upl

oa"s,-..H,//,bottle"&(ater)Ep


12/19

B6; Butylate" hy"roxyanisole $B6;% B6; is a co##on a""iti'e to popular

oo"s 3n general B6; is use" to =eep ats ro#

spoiling $ational 3nstitute oEn'iron#ental 6ealth Sciences1 -./0%

ational 3nstitute o En'iron#ental 6ealth Sciences1 Bisphenol ; $B2;% uestions an";ns(ers about Bisphenol ;1 ?uly)/A)-./0http+,,((()niehs)nih)go',health,topics,agents,sya&bpa,

http+,,((()(o#enshealth#ag)co#,Gles,(h>9uploa"s,i#ages,salty&chips)pg

http+,,((()tbh:

)org,i#,b

ha

9gra

ph)Ep

g


13/19

*6E MODEL ORI;3SM+Gambusia hobrooki

Li'e bearers Distinguish bet(een #ales an" e#ales 6earty 6istory o being use" in EDC research

;ll Xertebras ha'e si#ilar traits in regar"s to "e'elop#entalprocesses1 physiology an" beha'ior

http+,,((()cps)e"u,islan"cree=es,ecology,ish,Eastern


14/19

ME*6ODS+We (ant to co#pare high an" lo( "oses

as (ell as co#bine" "oses o B2; an"B6;)

ote+ Dosages (ere chosen base" on or#er stu"ies exploring the efects oestra"iol $Reyhanian et al n)"% an" B2; $Molina ;1 et al -./-% in ebraGsh an"

a""itional stu"ies on B6; $ES; panel B6; -.//%)


15/19

*3MEL3E Z *RE;*ME*+Beha'iors such as #ating1 aggression1 an"

hyperacti'ity (ill be obser'e" an" charte")

Upon closure o the experi#ent1 the Gsh (ill be

"issecte"1 to obser'e structural anato#icalabnor#alities1 as (ell as #orphological changesin gona"al "e'elop#ent $Molina ;) et al -./-%)So#e tissue sa#ples (ill be ta=en an" an EL38;

(ill be run Molina ;1 Lora ;1 Blanco ;1 Monter"e ?1 ;yala 1 Moyano R) $-.//% En"rocrine&acti'eco#poun" e'aluation+ ualitati'e an" :uantitati'e histo#orphological assess#ent oebraGsh gona"s ater bisphenol&; exposure) Ecotoxicology an" en'iron#ental


16/19

+6ypothesis 6/+ 3n"i'i"uals treate" (ith in"i'i"ual an" co#bine" EDCs (ill

"isplay "iferent repro"ucti'e "e'elop#ent an" beha'ioral

characteristics than the control&no treat#ent group)

6-+ 3n"i'i"uals treate" (ith in"i'i"ual an" co#bine" EDCs (ill"isplay si#ilar repro"ucti'e "e'elop#ent an" beha'ioralcharacteristics to the positi'e control&estra"iol group)

60+ 3n"i'i"uals treate" (ith B6; (ill ha'e lo(er beha'ioral1repro"ucti'e1 an" anato#ical abnor#alities then the B2; treate"tan=s)

67+ *he co#bine" tan=s are expecte" to ha'e higher estrogenicproperties1 (ith the tan= being treate" (ith both high "oses o B2;an" B6; to ha'e synergetic anato#ical1 beha'ioral1 an"repro"ucti'e abnor#alities1 si#ilar to that o a high a#ount oestrogen exposure


17/19

;n exa#ple o #orphological

characteristicsJ

6ypothesis Continue"

$Molina ;) et al -./-%


18/19

*6E 2RO?EC* 3S S*3LL IO3I

*his su##er (e co#plete"+ Buil"ing the Gsh lab*an= set upWater :uality stabiliation

Starte" a bree"ing colonyResults o this proect are expecte" to bepresente" at S3CB $Society or 3ntegrati'e an"Co#parati'e Biology% in ?anuary -./4


19/19

;c=no(le"ge#ents; special than= you to SUR) *he SUR un"ingpro'i"e" a stipen" that allo(e" #e to stay an"continue research o'er the su##er *he Irant allo(e" or the ree"o# to explore

the efects o these en"ocrine "isrupting

che#icals in a (ay that is rele'ant to bothen'iron#ental health an" hu#an health)

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Endocrine Disrupting Chemicals