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7/22/2019 Emergency in Medicine 2012
http://slidepdf.com/reader/full/emergency-in-medicine-2012 1/202
Emergency in medicine
4 April 2012
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Scope
Cardiopulmonary resuscitation
Cardiac arrhythmia
Acute coronary syndrome
Fast track MI
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Cardiopulmonary
resuscitation
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VF/ Pulseless VT
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Ventricular Fibrillation
Multiple ventricular foci rapidly discharge
producing a totally erratic ventricular
rhythm without identifiable waves
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Ventricular tachycardia
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Ventricular Tachycardia (VT)
•Regular rhythm (may be slightly irregular)•Rate ~150-250/min
•Wide QRS complex
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Polymorphic VT
+ Prolong QT = Torsades de pointes
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Defibrillation Provide most effective
treatment for
ventricular fibrillation
as soon as possible
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Manual Defibrillator
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Manual Defibrillators
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1.Turn on or monitor on
Step Manual Defibrillation
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2. Set lead select•Paddle lead
•Lead I, II, III
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3. Analyze rhythm
4. If VF or pulseless VT Defibrillation
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Select energy level•Monophasic :360J
•Biphasic:120-200 J
(If unknown use 200J)
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5. Apply gel to paddle
or use adhesive pad6. Apply paddle or pad
at correct position
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7.Charge defibrillator by
•Press button on control panel
•Or at right hand apex paddle
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8. When fully charged : voice &
number
9. Say One , I am clear Two , you are clear
Three , everybody is clear
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10. Press 2 discharge button simultaneously
11. Check monitor. If VF/VT remains , startCPR for 5 cycles
VF/P l l VT
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VF/Pulseless VT Give 1 shock •Manual biphasic:120-200J•Monophasic:360J• AED: device specificResume CPR immediately
Shockable rhythm?
•Give 1 shock •Resume CPR immediately after the shock
• Vasopressor when IV/IO available•Epinephrine 1mg IV/IO every 3-5 min or• Vasopressin 40 U IV/IO
Give 5 cycles of CPR
Shockable rhythm?
Give 5 cycles of CPR
Shockable
•Give 1 shock •Resume CPR immediately after the shock
•Consider antiarrhythmics• Amiodarone 300 mg IV/IO then consider additional 150 mg IV/IO•Lidocaine (1-1.5 mg/kg then 0.5-0.75 mg/kg IV/IO)
•Magnesium 1-2 g IV/IO for torsades de pointes
Shockable
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Asystole/ PEA
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Asystole
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Confirm true asystole
Check lead & cable connections
Monitor power on?
Monitor gain up?
Verify asystole in another lead?
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Pulseless Electrical activity
(PEA)Electrical mechanical dissociation
Treatment goal is to bring back perfusion
(pulse and blood pressure)Correct the reversible cause is the key
factor for success resuscitation
The process is to perform cardiopulmonarysupport and try to identify and correct the
causes
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Search for & treat possible
contributing factors
5HHypovolemia
Hypoxia
Hydrogen ion
(acidosis)
Hypo/hyperkalemia
Hypoglycemia
Hypothermia
5TToxins
Tamponade (cardiac)
Tension
pneumothorax
Thrombosis (coronary
or pulmonary)
Trauma
(hypovolemia,increased ICP)
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Key changes from the 2005 ACLS
Guidelines
Continuous quantitative waveform capnography for confirmation andmonitoring of endotracheal tube placement
Emphasize the importance of high-quality CPR (including chest
compressions of adequate rate and depth, allowing complete chestrecoil after each compression, minimizing interruptions in chestcompressions and avoiding excessive ventilation)
Atropine is no longer recommended for routine use in themanagement of pulseless electrical activity (PEA)/asystole
There is an increased emphasis on physiologic monitoring tooptimize CPR quality and detect ROSC
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Cardiac arrhythmia
Tachyarrhythmia
Bradyarrhythmia
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Approach to cardiac arrhythmia
Rhythm –
qu ick look
Flat l ine
Use electrod e and loo k for 2 leads
Look for connect ion
Sti l l f lat l ine
= Asysto le
VF QRS com plex
Rate > 100
Tachycardia
Rate < 60
Bradycard ia
Narrow QRS Wide QRS
Regular Irregular
SVT
Regular Irregular
AF
Atr ial f lut ter
MAT
VT
SVT with
aberrant
SVT with BBB
AF
with
WPW
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Tachyarrhythmia
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Tachyarrhythmia-Management in CPR
Identify the hemodynamic effects of tachyarrhythmia
Electrical therapy should be
performed at any time if the patientbecomes unstable.
Antiarrhythmic medication could be
used initially in stable tachyarrhythmia
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Unstable Tachycardia
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Cardioversion
St C di i
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Step Cardioversion
! Consider sedation
1. Turn on or Monitor on
2. Attach monitor leads
3. Press “ sync ” button at control panel 4. Look for marker on R wave
5. Adjust monitor gain until sync marker occur
6. Select energy level and charge
7. Apply gel and place paddle at correct position
8. Clear : One , Two , Three
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9. Press discharge botton10. Analyze rhythm again
Narrow regular 50-100 jNarrow irregular 120-200 j (Bi), 200 j (Mo)
Wide regular 100 j
Wide irregular Defib
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Synchronized
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Narrow QRS complex
Wide QRS complex
Stable Tachycardia
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Narrow QRS-ComplexTachycardia
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Narrow Complex Tachycardia
Regular Irregular
No P waveP wave
-AF-PAC
-MAT
-AT with block
-A.Flutter + block
A.Flutter 2:1
PSVT-AVNRT
-AVRT
-AT
Sinus tachycardia
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Irregular Narrow QRS-
Complex Tachycardia
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Atrial Fibrillation (AF)
Irregular rhythm
Not seen P wave
(fibrillate baseline)
Atrial rate ~350-500/min
Ventricular ratevariable
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Atrial Fibrillation (AF)
•Irregular rhythm
•Not seen P wave (fibrillate baseline)
• Atrial rate ~350-500/min
•Ventricular rate variable
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Atrial Flutter
Regular or irregular
rhythm
Atrial rate 250-
350/minVentricular rate 1/2,
1/3, … of atrial rate
“Saw tooth”
appearance
AV block 2:1, 3:1,…
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Atrial Flutter
•Regular or irregular rhythm
• Atrial rate 250-350/min
•Ventricular rate 1/2, 1/3, … of atrial rate
•“Saw tooth” appearance
•AV block 2:1, 3:1,…
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Recommendations for Pharmacological or
Electrical Cardioversion of AF
Class I
1. Immediate electrical cardioversion in patients with
paroxysmal AF and a rapid ventricular response who have
ECG evidence of acute MI or symptomatic hypotension,angina, or HF that does not respond promptly to
pharmacological measures. (Level of Evidence: C )
2. Cardioversion in patients without hemodynamicinstability when symptoms of AF are acceptable.
(Level of Evidence: C )
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Electrical cardioversion
Synchronized mode, Initial energy 200 J
Increments of 100 J until a maximum of
400 J
Lower energies are required with biphasicwaveforms
Interval between 2 consecutive shocks
should not be < 1 min.
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Risk & Complication of electrical
cardioversion
Embolism
– 1-7% : if no prophylactic anticoagulant before
cardioversion
Arrhythmia
– Hypokalemia
– Digitalis intoxication
Myocardial Injury
– Transient ST elevation and small increased bloodlevel of CK-MB.
– Probably not clinically significant
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Prophylaxis of Thromboembolism
before Cardioversion
Anticoagulate patients with AF lasting more than 48 h or of unknown duration, for at least 3 to 4 weeks before
and after cardioversion (INR 2 to 3).
Screening for the presence of thrombus in the LA or LAA by TEE is an alternative for routinepreanticoagulation in candidates for cardioversion of AF.
M di l i At i l fib ill ti
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Medical conversion Atrial fibrillation
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Typical Doses of Drugs Used to Maintain Sinus Rhythm
in Patients With Atrial Fibrillation
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Anticoagulant
CHADS2 ( CHF , HT , age > 75 yrs , DM ,stroke ) ≥ 2
no contraindication
keep INR 2-3
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Vascular disease (prior MI, PAD, Aortic plaque ) ESC 2010
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Regular Narrow QRS-
Complex Tachycardia
Paroxysmal Supraventricular
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Paroxysmal Supraventricular Tachycardia (PSVT)
Rate ~150-250/min,Regular rhythm
Abrupt onset &termination
Not seen sinus Pwave (usually notseen P wave or retrograde P wave)
Usually narrow QRScomplex
Paroxysmal Supraventricular
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Paroxysmal Supraventricular Tachycardia (PSVT)
•Rate ~150-250/min, Regular rhythm
•Usually narrow QRS complex
•Abrupt onset & termination
•Not seen sinus P wave (usually not seenP wave or retrograde P wave)
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Management
Unstable VS : sedation+Cardioversion synchronized
biphasic 50-100 j , adenosine
Stable VS : Adenosine 6 mg rapidly iv if ineffective within 1-2 min give 12 mg
Nausea,light-headedness,flushing
Contraindication in asthma, second or third degree AV
block , sick sinus syndrome
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Management
Diltiazem 0.25 mg/kg over 2 min, further 0.35 mg/kg after 15 min if
required
Initial infusion 5-10 mg/hr , increased 5-15 mg/hr up to
24 hr, maintainance 120-360 mg oral daily
Verapamil 5-10 mg slowly iv (over 2-3 min) repeated 10 mg in 10-
15 min , oral maintainance 120-480 mg daily divided in
3-4 doses
Contraindication in hypotension , bradycardia , wide
complex tachycardia , VT
Narrow QRS
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Narrow QRS
• Attempt vagal maneuvers•Give adenosine 6 mg IV push.If no conversion give 12 mg IV push
Irregular Narrow-ComplexTachycardia AF/atrial flutter/MAT•Consider expert consultation•Control rate
Convert?
If rhythm convertsProbable reentry SVT
If rhythm does not convertPossible atrial flutter, atrial tachycardia,
junctional tachycardia
Regular Irregular
Converts Does not convert
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Wide QRS-ComplexTachycardia
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Approach to wide complex tachycardia
History of MI favor VT
Age,rate and hemodynamic cannot differentiate
Differential diagnosis of wide complex tachycardia
1) Ventricular tachycardia
2) SVT with aberrant conduction
3) SVT with preexisting bundle branch block
4) circus movement tachycardia in WPW
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Clues for VT
AV dissociation
Fusion beat
Capture beat
Axis : No man’s land , LBBB with RAD
QRS morphology
Precordial concordance : negative specific more
than positive
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AV dissociation in VT
VA conduction are also seen
Positive concordance
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VT N ’ l d
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VT – No man’s land
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Management
Amiodarone Oral loading dose 1200-1600 mg daily , maintainance
200-400 mg daily
Intravenous loading 150 mg over 10 min then 360 mg
over 6 hr then 560 mg over remaining 18 hr then 0.5
mg/min
Contraindication in severe bradycardia , prolong QT
V t i l T h di (VT)
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Ventricular Tachycardia (VT)
•Regular rhythm (may be slightly irregular)
•Rate ~150-250/min
•Wide QRS complex
P l hi VT
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Polymorphic VT
Like VT but QRS complexes different inmorphology
Typical: QRS complexes spiral around the
baseline, changing their axis andamplitude.
Polymorphic VT + prolong QT interval =
Torsades de pointes
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Bradyarrhythmia
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Bradyarrhythmia
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Bradyarrhythmia
Sinus node dysfunction AV block
1st degree AV block
2nd degree AV block
3nd degree AV block
2nd degree AV block type I
2nd
degree AV block 2:1
2nd degree AV block typeII
Advanced 2nddegree AV block
Sinus arrest /pause
Sinus exit block
Sinus bradycardia
Tachy-brady syndrome
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E Rh th
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Escape Rhythms
Escape beats= rescuing beats originatingoutside the sinus node
AV Node (junctional rhythm): 40 to 60
beats/minute , narrow QRS
Ventricles: 30 to 40 beats/minute , wide
QRS
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Sinus bradycardia
Sinus rhythm
Rate<60/min
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Sinus Arrestand SA Exit
Block
T h b d d
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Tachy-brady syndrome
J ti l h th
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Junctional rhythm
J ti l h th
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Junctional rhythm
Rate 40-60/min
Most often not seen P wave (Occasional
retrograde P wave)
Narrow QRS complex
Idio entric lar rh thm
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Idioventricular rhythm
Rate 30-40 /min
Wide QRS complex
AV Block
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First degree AV block
Second degree AV block
– Type I (Wenchkebach)
– Type II
– 2:1 second degree AV block
– Advanced second degree AV block
Third degree AV block
AV Block
1st DEGREE AV BLOCK
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1st DEGREE AV BLOCK
PR interval >0.2 sec
All beats are conducted through to the ventricle
2nd DEGREE AV BLOCK: Mobitz
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type I (Wenckebach)
Progressive prolongation of the PR interval until
a QRS is dropped
2nd DEGREE AV BLOCK: Mobitz
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type II
QRS complexes are dropped at regular intervals
without prolongation of the PR interval
2nd DEGREE AV BLOCK 2:1
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2nd DEGREE AV BLOCK 2:1
2 sinus P wave: 1 QRS complex
Constant PR interval(Impossible to tell whether it is Mobitz I or II)
High grade AV block
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g g
(Advanced AV block)
≥ 3:1 AV block
Constant PR interval
Third degree AV block
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Third degree AV block
No beats are conducted through to the
ventricles.
AV dissociation: atrium and ventricles are driven
by independent pacemakers
Bradycardias
• slow (rate < 60 bpm)
BradycardiaAlgorithm
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( p )
• relatively slow
Primary CAB survey
Serious signs or symptoms ?
Due to Bradycardia ?
Type II second-degree AV block
Third-degree AV block
Intervention sequences
• Atrop ine 0.5-1 mg
• Transcu taneous pacing
• Dopamine 5-20 ug/kg/min
• Epinephr ine 2-10 ug/min
•Isoproterenol 2-10ug/kg
Observe • Prepare for transvenous pacer
• If symptoms develop, transcutaneous pacing
----> transvenous pacing placed
NO YES
NO YES
g
Search for & treat possible
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contributing factors
5HHypovolemia
Hypoxia
Hydrogen ion
(acidosis)
Hypo/hyperkalemia
HypoglycemiaHypothermia
5TToxins
Tamponade (cardiac)
Tension
pneumothorax
Thrombosis (coronary
or pulmonary)Trauma
(hypovolemia,increased ICP)
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Transcutaneous Pacing
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Pacing Control
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Pacing Control
Method
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Method
1. Attach electrode.
2. Turn on pacemaker at desire rate.
3. In bradyasystolic arrest, set initial output tomaximum; once capture has been confirmed,↓output until threshold determined.
4. In conscious patient, start with minimumoutput and↑ until threshold is achieved.
5. Set output at 10-20% above capture
threshold.6. Give sedative & analgesia as needed.
Capture
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Capture Definition:Cardiac depolarization and
resultant contraction caused by
pacemaker stimulus
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Acute coronary syndrome
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References
Guideline UA/NSTEMI ACC/AHA
2007
Guideline STEMI ACC/AHA 2007 ,
2009
Pathophysiology of ACSL
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Fuster V et al NEJM 1992;326:310 – 318
Davies MJ et al Circulat ion 1990;82(Suppl II):II –
38, II –
46
Lipid pool
Macrophages
Stress, tensile,internal
Shear forces,external Fissure
Largefissure
Smallfissure
Mural thrombus(unstable angina/NSTEMI)
Occlusive thrombus(STEMI)
Atheroscleroticplaque
Plaquedisruption
Thrombus
Example of atherosclerosis
disease progression
Spectrum of Acute Coronary
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Spectrum of Acute Coronary
Syndrome
Q-wave MIUnstable Angina
Ischemic Discomfort at Rest
No ST Elevation ST Elevation
Non ST Elevation MI
Braunwald E et al . J Am Coll Cardiol 2000;36:970 – 1062.
≥0.2 mV in V1-3
≥0.1 mV in other lea
>2 contiguous leads
Di i
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Diagnosis
Clinical presentation
ECG finding
Cardiac Biomarker
Clinical presentation
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AnginaRetrosternal chest pain, burning, heaviness
Radiating to neck,jaw,epigastrium,shoulder ,Lt arm
Precipitated by exercise,cold weather,emotional stress
Duration < 2-10 min
Rest or unstable anginaSame as angina , more severe
Typical <20 min
Acute myocardial infarctionSame as angina , more severe
Sudden onset, often with shortness of breathing,weakness, nausea , vomitting
Usually lasting 30 min or longer
PericarditisSharp, pleuritic pain
Aggravated by changes in positions, variable in duration, pericardial friction rub
Braunwald’ s Heart disease ,textbook of cardiovascular medicine eight edition
ED Evaluation of
Patients With STEMI
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Patients With STEMI
Aortic dissection
Pulmonary embolus
Perforating ulcer
Tension pneumothorax
Boerhaave syndrome
(esophageal rupture with
mediastinitis)
Differential Diagnosis of STEMI: Life-Threatening
ED Evaluation of
Patients With STEMI
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Gastroesophageal reflux
(GERD) and spasm
Chest-wall pain
PleurisyPeptic ulcer disease
Panic attack
Cervical disc or neuropathic
pain
Biliary or pancreatic pain
Somatization andpsychogenic pain disorder
Patients With STEMI
Differential Diagnosis of STEMI: Other Noncardiac
ECG fi di
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ECG finding
ST Elevation
> 0.2 mV in leads V1-3
> 0.1 mV in other leads
Elevation in at least 2 contiguous leads
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Comparison of EKG Changes Associated with Acute Pericarditis,
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Myocardial Infarction and Early Repolarization
ECG Finding
Acute
Pericarditis
Myocardial
Infarction
Early
Repolarization
ST-segment shape Concave upward Convex upward Concave upward
Q waves Absent Present Absent
Reciprocal ST-
segment changes
Absent Present Absent
Location of ST-
segment elevation
Limb and precordial
leads
Area of involved
artery
Precordial leads
ST/T ratio in lead V6 >0.25 N/ A <0.25
Loss of R-wave
voltage
Absent Present Absent
PR-segment
depression
Present Absent Absent
Marriott Practical Electrcaediography 10th
edition
Early repolarization
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y p
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LVH LBBB pericarditisHyper K
ASMI Brugada
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Acute Inferior wall MI
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Acute Anterior wall MI
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Wall ST elevation
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Wall
Septal
Anterior
Anteroseptal
Extensive anterior
LateralHigh lateral
Anterolateral
Inferior
RV infarctposterior
ST elevation
V1-V2
V3-V4
V1-V4
V1-V6
V6, I, AVLI, AVL
V3-V6, AVL
II, III, AVF
V3R-V4RTall R in V1
Corelation of Wall and coronary vessel
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Progression of Nonreperfused Q-
AMI
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wave AMI
Biochemical Cardiac Markers
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ESC/ACCF/AHA/WHF Expert Consensus Document,
JACC Vol. 50, No. 22, 2007 :2173 –95
Management
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g
Generalmanagement
Oxygenation
AnalgesiaNTG
Blood sugar control
Specificmanagement
Reperfusion
Antiplatelets Anticoagulant
Betablocker
ACEI/ARB Aldosterone blockade
Statin
Analgesia
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Morphine remains Class I for STEMIalthough may increase adverse events in
UA/NSTEMI
NSAID medications increase mortality,reinfarction, and heart failure in proportion
to degree of COX-2 selectivity
– Discontinue on admission for STEMI– Do not initiate during acute phase of
management
ACC/AHA guideline for STEMI 2007
Oxygen
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Supplemental oxygen should be administered topatients with arterial oxygen desaturation (SaO2
< 90%).
It is reasonable to administer supplemental
oxygen to all patients with uncomplicated STEMI
during the first 6 hours.
III IIaIIaIIa IIbIIbIIb IIIIIIIIIIII IIaIIaIIa IIbIIbIIb IIIIIIIIIIII IIaIIaIIa IIbIIbIIb IIIIIIIIIIIaIIaIIa IIbIIbIIb IIIIIIIII
I I I IIa IIa IIa IIb IIb IIb III III III I I I IIa IIa IIa IIb IIb IIb III III III I I I IIa IIa IIa IIb IIb IIb III III III IIa IIa IIa IIb IIb IIb III III III
ACC/AHA guideline for STEMI 2007
Nitroglycerin
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Patients with ongoing ischemic discomfort should
receive sublingual NTG (0.4 mg) every 5 minutes for atotal of 3 doses, after which an assessment should be
made about the need for intravenous NTG.
Intravenous NTG is indicated for relief of ongoing
ischemic discomfort that responds to nitrate therapy,
control of hypertension, or management of pulmonary
congestion.
III IIaIIaIIa IIbIIbIIb IIIIIIIIIIII IIaIIaIIa IIbIIbIIb IIIIIIIIIIII IIaIIaIIa IIbIIbIIb IIIIIIIIIIIaIIaIIa IIbIIbIIb IIIIIIIII
III IIaIIaIIa IIbIIbIIb IIIIIIIIIIII IIaIIaIIa IIbIIbIIb IIIIIIIIIIII IIaIIaIIa IIbIIbIIb IIIIIIIIIIIaIIaIIa IIbIIbIIb IIIIIIIII
ACC/AHA guideline for STEMI 2007
Nitroglycerin Contraindications
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Nitrates should not be administered when:
Nitrates should not be administered to
patients who have received aphosphodiesterase inhibitor for erectile
dysfunction within the last 24 hours (48
hours for tadalafil).
• systolic pressure < 90 mm Hg or ≥ to 30 mm Hg
below baseline
• severe bradycardia (< 50 bpm)
• tachycardia (> 100 bpm) or • suspected RV infarction.
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Specific management
Reperfusion Options for STEMIPatients
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Reperfusion Options for STEMI PatientsSelect Reperfusion Treatment.
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Fibrinolysis generally preferred
Early presentation ( ≤ 3 hours from symptom
onset and delay to invasive strategy)
Invasive strategy not an option
Cath lab occupied or not available Vascular access difficulties
No access to skilled PCI lab
Delay to invasive strategy
Prolonged transport Door-to-balloon more than 90 minutes
> 1 hour vs fibrinolysis (fibrin-specific agent) now
If presentation is < 3 hours and there is no delay to an invasive
strategy, there is no preference for either strategy.
ACC/AHA guideline for STEMI 2007
Reperfusion Options for STEMI PatientsSelect Reperfusion Treatment.
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Invasive strategy generally preferred
Skilled PCI lab available with surgical backup
Door-to-balloon < 90 minutes
• High Risk from STEMI
Cardiogenic shock, Killip class ≥ 3
Contraindications to fibrinolysis, including
increased risk of bleeding and ICH
Late presentation > 3 hours from symptom onset
Diagnosis of STEMI is in doubt
If presentation is < 3 hours and there is no delay to an invasive strategy,
there is no preference for either strategy.
ACC/AHA guideline for STEMI 2007
Primary PCI
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STEMI patients presenting to a hospital with PCIcapability should be treated with primary PCI within
90 min of first medical contact as a systems goal.
STEMI patients presenting to a hospital without PCI
capability, and who cannot be transferred to a PCI
center and undergo PCI within 90 min of first
medical contact, should be treated with fibrinolytic
therapy within 30 min of hospital presentation as asystems goal, unless fibrinolytic therapy is
contraindicated.
I I I IIa IIa IIa IIb IIb IIb III III III I I I IIa IIa IIa IIb IIb IIb III III III I I I IIa IIa IIa IIb IIb IIb III III III IIa IIa IIa IIb IIb IIb III III III
I I I IIa IIa IIa IIb IIb IIb III III III I I I IIa IIa IIa IIb IIb IIb III III III I I I IIa IIa IIa IIb IIb IIb III III III IIa IIa IIa IIb IIb IIb III III III
ACC/AHA guideline for STEMI 2007
Application of PCI for STEMI
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STEMI
Thrombolysis Primary PCI
Success Failure
Rescue PCI Routine
immediateor urgent PCI
RoutineDeferred CAG+ PCI
Selective CAG
+ PCI only for High-risk pts
Curr Prob l Cardiol, January 2003
Facilitated PCI
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Rescue and Late PCI
Assessment of Reperfusion
It is reasonable to monitor the pattern of ST elevationIII IIaIIaIIa IIbIIbIIb IIIIIIIIIIII IIaIIaIIa IIbIIbIIb IIIIIIIIIIII IIaIIaIIa IIbIIbIIb IIIIIIIIIIIaIIaIIa IIbIIbIIb IIIIIIIII
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It is reasonable to monitor the pattern of ST elevation,
cardiac rhythm and clinical symptoms over the 60 to 180
minutes after initiation of fibrinolytic therapy.
Noninvasive findings suggestive of reperfusion include:
Relief of symptoms
Maintenance and restoration of hemodynamic and/or
electrical instability
Reduction of ≥ 50% of the initial ST-segment elevation
pattern on follow-up ECG 60 to 90 minutes after
initiation of therapy.
ACC/AHA guideline 2007
Rescue PCI
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PCI in no reperfusion after fibrinolytic therapy
Failed reperfusion
ongoing chest pain
resolution of ST elevation < 50 %
Early peak of cardiac enzyme
Benefit ( Meta-analysis in 2007)
Mortality rate 10.4% to 7.3 % ( RR 0.69, 95% CI 0.46-1.05 ; p=0.09)
Reinfarction 10.7% to 6.1 % ( RR 0.58, 95% CI 0.35-0.97 ; p=0.04)
Heart failure 17.8% to 12.7 % ( RR0.73,95% CI 0.54-1.00 ; p=0.05)
Thrombolytic Therapy
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y y
Indications ?
Contraindications ?Which drug ?
How fast to be given ?
Conjunctive antithrombotics ?
ST segment elevation
> 0 2 mV in leads V1-3
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Indicationfor
fribinolysis
TherapyIn STEMI
> 0.2 mV in leads V1 3
> 0.1 mV in other leads
Elevation in at least 2 continuous leadsor new LBBB
Duration < 12 hr (class I)
12-24 hr with ongoing pain ( class IIa)
No contraindications
TIMI Risk Score for STEMI Risk Score Odds of death by 30D*
Mortality prediction of STEMI
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Age65-74 75
DM/HTN or angina
Weight < 67 kg
Time to rx > 4 hrs
Anterior STE or LBBB
HR >100
SBP < 100
Historical
Exam
Presentation
Killip II-IV
2 points3 points
1 point
3 points
2 points
1 point
1 point
1 point
2 points
Risk Score = Total (0 -14)
0
12
3
4
56
7
8
>8
0.1 (0.1-0.2)
0.3 (0.2-0.3)
0.4 (0.3-0.5)
0.7 (0.6-0.9)
1.2 (1.0-1.5)
2.2 (1.9-2.6)
3.0 (2.5-3.6)
4.8 (3.8-6.1)
5.8 (4.2-7.8)
8.8 (6.3-12)
*referenced to average mortality
(95% confidence intervals)
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Thrombolytic Therapy
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Indications ?
Contraindications ?Which drug ?
How fast to be given ?
Conjunctive antithrombotics ?
Absolute Contraindications for
Thrombolytic Rx
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y
Any prior ICHKnown structural cerebral vascular lesion
Malignant intracranial neoplasm
Ischemic stroke within 3 monthsSuspected aortic dissection
Active bleeding diathesis (excluding menses)
Significant closed-head or facial traumawithin 3 months
Relative Contraindications for
Thrombolytic Rx
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Chronic severe poorly controlled HTN
Severe uncontrolled HTN on presentation SBP>180,DBP>110
Prior ischemic stroke > 3 months, intracranialpathology
Traumatic or prolonged >10 min CPR or major surgerywithin 3 weeks
Recent within 2-4 weeks internal bleeding
Noncompressible vascular puncture
SK, anistreplase: prior exposure > 5 days ago or prior
allergic reactionPregnancy
Active peptic ulcer
Current use of anticoagulation
Risks for ICH After Thrombolysis
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Age > 65
Weight < 70 kg
FemaleHypertension
Use of tPA
Thrombolytic Therapy
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Indications ?
Contraindications ?Which drug ?
How fast to be given ?
Conjunctive antithrombotics ?
Thrombolytic Agents
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First generation Second generation Third generation
Streptokinase* APSAC Reteplase* (r-PA)
Urokinase Alteplase* Lanoteplase* (n-PA)
Staphylokinase Saruplase TNK-PA
Staphylokinase
Thrombolytic Agents in
Clinical Practice
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• SK 1.5 mu IV > 1 hr
• Accelerated tPA 15 mg IV bolus
50 mg (0.75 mg/kg) IV in 30 min
35 mg (0.5 mg/kg) IV in 60 min
Clinical Practice
Comparison
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Streptokinase Alteplase Reteplase Tenecteplase
•Dose 1.5 MU over Up to 100mg in 10U x 2 30-50mg
30-60 min 90 min (wt-based) each over 2 min based on weight
•Bolus Admin. No No Yes Yes
•Antigenic Yes No No No
•Allergic React Yes No No No
•Systemic Marked Mild Moderate Minimal
Fibrinogen Depletion
• ~90-min patency 50 75 75? 75
rates (%)•TIMI grade 3 flow, % 32 54 60 63
Antiplatelets
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Aspirin
Thienopyridines
Glycoprotein IIb/IIIa receptor antagonist
Aspirin
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Reduce mortality
Reduce coronary reocclusion
Reduce recurrent ischemic events
Aspirin
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Aspirin should be chewed by patients who
have not taken aspirin before presentation
with STEMI. The initial dose should be
162 mg to 325 mg
Although some trials have used enteric-coated aspirin for initial dosing, more rapid buccal absorption occurs with
non –enteric-coated formulations.
ACC/AHA guideline for STEMI 2007
Complementary Mode of Action between
Clopidogrel and ASA
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p g
COX, cyclooxygenase; ADP, adenosine diphosphate; TxA2,
thromboxane A2
Schafer AI Am J Med 1996;101:199 209
Clopidogrel is an advanced ADP receptor antagonist and
inhibits platelet aggregation by antagonizing the effects of ADP
ST-Elevation MI: ClopidogrelTrials
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COMMIT / CCS-2
46,000 patients
Mortality, D / MI / CVA
AMI < 24 hrs
Age up to 100
~ 50% lytic
No loading dose China
Non-invasive strategy
3,500 Patients
Infarct artery patency
AMI < 12 hrs
Age < 75
100% fibrinolytic
Loading dose Europe / N. America
Invasive strategy
Thie
nopyridines
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Clopidogrel 75 mg per day orally should be added toaspirin in patients with STEMI regardless of whether
they undergo reperfusion with fibrinolytic therapy or
do not receive reperfusion therapy.
Treatment with clopidogrel should continue
for at least 14 days.
I I I IIa IIa IIa IIb IIb IIb III III III I I I IIa IIa IIa IIb IIb IIb III III III I I I IIa IIa IIa IIb IIb IIb III III III IIa IIa IIa IIb IIb IIb III III III
I I I IIa IIa IIa IIb IIb IIb III III III I I I IIa IIa IIa IIb IIb IIb III III III I I I IIa IIa IIa IIb IIb IIb III III III IIa IIa IIa IIb IIb IIb III III III
ACC/AHA guideline for STEMI 2007
Thie
nopyridines
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In patients < 75 years who receive fibrinolytic
therapy or who do not receive reperfusion therapy, it
is reasonable to administer an oral clopidogrel
loading dose of 300 mg. (No data are available to
guide decision making regarding an oral loading
dose in patients ≥ 75 years of age.)
Long-term maintenance therapy (e.g., 1 year) with
clopidogrel (75 mg per day orally) can be useful in
STEMI patients regardless of whether they undergo
reperfusion with fibrinolytic therapy or do not
receive reperfusion therapy.
I I I IIa IIa IIa IIb IIb IIb III III III I I I IIa IIa IIa IIb IIb IIb III III III I I I IIa IIa IIa IIb IIb IIb III III III IIa IIa IIa IIb IIb IIb III III III
I IIa Ia Ia IIb Ib Ib III II II IIa Ia Ia IIb Ib Ib III II II IIa Ia Ia IIb Ib Ib III II II Ia Ia Ia IIb Ib Ib III II II
ACC/AHA guideline for STEMI 2007
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ACC/AHA guideline for STEMI 2009
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Anticoagulant
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Anticoagulant
Reduce reocclusion
Reduce reinfarction
Reduce recurrent ischemia
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Heparin
LMWH
Fondaparinux
Bivalirudin
Anticoagulants
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Patients undergoing reperfusion with fibrinolytics
should receive anticoagulant therapy for a minimum of
48 hours (Level of Evidence: C) and preferably for the
duration of the index hospitalization, up to 8 days
(regimens other than unfractionated heparin [UFH] are
recommended if anticoagulant therapy is given for morethan 48 hours because of the risk of heparin-induced
thrombocytopenia with prolonged UFH treatment).
(Level of Evidence: A)
Anticoagulant regimens with established efficacyinclude:
♥ UFH (LOE: C)
♥ Enoxaparin (LOE:A)
♥ Fondaparinux (LOE:B)
I I I IIa IIa IIa IIb IIb IIb III III III I I I IIa IIa IIa IIb IIb IIb III III III I I I IIa IIa IIa IIb IIb IIb III III III IIa IIa IIa IIb IIb IIb III III III
I I I IIa IIa IIa IIb IIb IIb III III III I I I IIa IIa IIa IIb IIb IIb III III III I I I IIa IIa IIa IIb IIb IIb III III III IIa IIa IIa IIb IIb IIb III III III
ACC/AHA guideline STEMI 2007
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ACC/AHA guideline STEMI 2007
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Beta-Blockers
Beta-Blockers
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Reduce reinfarct size
Reduce reinfarction
Reduce life threatening ventricular tachyarrhythmias
Beta-Blockers
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Oral beta-blocker therapy should be initiated in the first 24
hours for patients who do not have any of the following: 1)signs of heart failure, 2) evidence of a low output state, 3)
increased risk* for cardiogenic shock, or 4) other relative
contraindications to beta blockade (PR interval > 0.24 sec,
2nd- or 3rd-degree heart block, active asthma, or reactive
airway disease).
It is reasonable to administer an IV beta blocker at the time of
presentation to STEMI patients who are hypertensive and who
do not have any of the following: 1) signs of heart failure, 2)
evidence of a low output state, 3) increased risk* for
cardiogenic shock, or 4) other relative contraindications to
beta blockade (PR interval > 0.24 sec, 2nd- or 3rd-degree heart
block, active asthma, or reactive airway disease).
I I I IIa IIa IIa IIb IIb IIb III III III I I I IIa IIa IIa IIb IIb IIb III III III I I I IIa IIa IIa IIb IIb IIb III III III IIa IIa IIa IIb IIb IIb III III III
I I I IIa IIa IIa IIb IIb IIb III III III I I I IIa IIa IIa IIb IIb IIb III III III I I I IIa IIa IIa IIb IIb IIb III III III IIa IIa IIa IIb IIb IIb III III III
ACC/AHA guideline STEMI 2007
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Inhibition of the Renin-Angiotensin Aldosterone
System
Inhibition of the Renin-Angiotensin-Aldosterone System
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Aldosterone System
ACEI/ARB
Reduce mortality
Aldosterone
blockadeReduce mortality
Reducehospitalization
ACE/ARB: Within 24 Hours
An ACE inhibitor should be administered orally
ithi th fi t 24 h f STEMI t th f ll i
III IIaIIaIIa IIbIIbIIb IIIIIIIIIIII IIaIIaIIa IIbIIbIIb IIIIIIIIIIII IIaIIaIIa IIbIIbIIb IIIIIIIIIIIaIIaIIa IIbIIbIIb IIIIIIIII
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within the first 24 hours of STEMI to the following
patients without hypotension or known class of contraindications:
• Anterior infarction
Pulmonary congestion
LVEF < 0.40
An ARB should be given to ACE-intolerant patients
with either clinical or radiological signs of HF or LVEF< 0.40.
III IIaIIaIIa IIbIIbIIb IIIIIIIIIIII IIaIIaIIa IIbIIbIIb IIIIIIIIIIII IIaIIaIIa IIbIIbIIb IIIIIIIIIIIaIIaIIa IIbIIbIIb IIIIIIIII
ACC/AHA guideline STEMI 2007
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Roles of statins in ACS
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Improve endothelial function
Repair ruptured atherosclerotic plaques
Improve plaque stabilization
Reduce thrombus formation on ruptureplaques
Cardiol Rev1999;16(Suppl.):1-6.
Prefer high dose atrovastation 80 mg/day
(MIRACL, PROVE-IT)
ST elevation
ASA clopidogrel Beta blocker statin
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ASA, clopidogrel,Beta-blocker,statin
< 12 hours
Thrombolytic Rx
contraindicated
SK Cardiac cath with
primary PTCA
Not candidate for
reperfusion Rx
Medical Rx: ACEI, Nitrates
> 12 hours
No Yes
Consider
reperfusion Rx
Persistent
symptoms
If failed SK,
rescue (salvage)
PTCA
Eligible for
thrombolytic Rx
D to N time <30 minD to balloon time 90+30 min
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1st
24 h
During Hosp Hosp DC +
Long Term
Summary of Pharmacologic Rx: LVD, Sec. Pre
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24 h Long Term
ACEI Anterior MI,Pulm Cong., EF < 40 Oral
Daily
OralDaily
IndefinitelyARB ACEI intol.,
HF, EF < 40
Aldo
Blocker
No renal dysf,
K+ < 5.0 mEq/L
On ACEI,
HF or DM
Same as
during
Hosp.
Statin Oral daily Oral daily Indefinitely,LDL <70-100
JACC 2004;44:671 , Circ 2004;110:588
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Fast Track MI
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การด แลผ ป วยโรคกลามเนอหัวใจตายเฉยบพลัน โรงพยาบาลสม ทรปราการ
checklist ตามแบบคัดกรองอาการเจบหนาอก
ผปวยเจบหนาอก
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แนวทางการด แลผ ป วย
แพทยซักประวัตตรวจรางกาย ตรวจคล นไฟฟ าหัวใจ และ Non invasive procedure เพ อทาการวนจฉัยและวนจฉัยแยกโรค
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ภาวะหัวใจขาดเลอดเฉยบพลัน โรคหัวใจขาดเลอดเร อรัง
เหมาะสมก ับการให SK หรอไม
ST Elevation Non ST elevation
ใหยาละลายล มเลอด (SK)
เปดหลอดเลอดดวย SK ไดหรอไม
ICU / CCU
มภาวะแทรกซอนหรอไม
ตดตามและรักษาอย างต อเน อง
สงตอเพ อทา Invasive procedure
เหมาะสม
ได
ไมม
ไมเหมาะสม
ไมได
ม
แบบคั ดกรองผ ปวยกลามเน อหัวใจตายเฉยบพ ลัน ช อ – สกล ............................................................................................................
HN. ………………………………….
วันท …………………………………. เวลา ………………………………….
เพ ………………………………….
รคประจาตัว
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รคประจ าตว ……………………………………………………………………………………
การแพยา ……………………………………………………………………………………
อาการ ขะซักประวัต 1. มอาการเจบหนาอกอย
2. ไมมอาการเจบหนาอกแลว
ลักษะการเจ บหนาอก 3. เจบแนนเหมอนถกทับกลางหนาอก
4. เจบราวไปทองแขนขางซาย, ราวข นกราม
5. เจบนานกวา 20 นาท 6. อาการเจบมากข นเม อออกแรง
7. เจบขะพัก
อาการรวม 8. เปนลมหมดสต 9. เหน อยหอบนอนราบไมได 10. อดอัดหายใจไมออก
11. เหง อแตก
12. ใจส ัน
13. คล นไสอาเจยน
ตรวจรางกายเบ องตน 14. Vital Sign BP_________mmHg, P_________ คร ัง/นาท, R_________ คร ัง
15. ซด
16. กระสับกระสาย
สงตอผ ปวยไปยัง ER [ถาเขาเก 1, 3 – 5, 8 – 10, 15 – 16 และตรวจรางการเบ องตน
SBP≥ 180, SBP < 100, P ≥ 100, P≤ 40, R ≥ 24, R ≤ 6]
หองทา ECG
พบแพทยอายรกรรม พบแพทย GP
แบบคัดกรองอาการเจบหนาอก
checklist ตามแบบคัดกรองอาการเจบหนาอก
ผปวยเจบหนาอก
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ER
Activate fast track MI
แนวทางการดแลผ ปวย Acute STEMI (Fast Track )
ผ ปวยมาดวยอาการเจบหนาอก
*Onset เวลา .............../....................(พยาบาลER )
เวลาท มาถงหองฉกเฉน .............../....................(พยาบาล ER )
ECG 12 Lead เวลา.............../....................(พยาบาล ER )
ช อ............................สกล...................
HN………………………………….
วันท ...................................................
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ประวัต / ตรวจรางกาย / แปลผล ECG โดยแพทยประจาหองฉกเฉน
เวลา.............../....................(แพทยประจาหองฉกเฉน)
ASA gr V 1 เมดเค ยวทันท เวลา .............../....................(พยาบาลER )
Clopidogrel 4 เมด ทันท (งด ถาอาย > 75 ป) เวลา.............../....................(พยาบาลER )
Troponin T เวลา.............../....................(พยาบาลER )
ปรกษาแพทยอายรกรรมมาด เวลา.............../....................(แพทยอายรกรรม) วนจฉัย...............................................
Admit เวลา.............../....................(แพทยอายรกรรม)
ออกจากหองฉกเฉน เวลา.............../....................(พยาบาลER )
เขาหอผ ปวย.......................................... เวลา.............../....................(พยาบาลWard)
รายงานแพทยประจา Ward เวลา.............../....................(พยาบาลWard)
แพทยประจา Ward ประเมนผ ปวยเวลา.........../..........(แพทย Ward) วนจฉัย...........................Killip……………..
*เร ม Streptokinase เวลา.............../....................(พยาบาลWard)
ประเมนผ ปวย (Symptom , ECG) หลังได Streptokinase 90 นาท เวลา.............../....................(พยาบาลWard)
ภาวะแทรกซอน (Major bleeding) ( ) ไมม ( ) ม ........................................................................
จาหนายจากหอผ ปวย ................................................................................
ถานการจาหนาย ( ) ทเลา ( ) เสยชวต
( ) ปเสธการรักษา ( ) สงตอไปท .............................................
Door to Needle time ……………hr ……………..min
าเหตท ไดรับการรักษาลาชา..................................................................................................................................................
................................................................................................................................................................................................
Fast track MI
checklist ตามแบบคัดกรองอาการเจบหนาอก
ผปวยเจบหนาอก
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ER หองทาECG
Activate fast track MI
Admit
ผล ECGเขาไดก ับ STEMI
ดแลรักษาตาม Caremap
standing order
เก บขอมลตามตัวช วดั
yes no
ส ง ER เขา fast track MI
Admit ward เขา fast track MI
พบอายรแพทยถามECGผดปกต
พบแพทยท ัวไปถาECG ปกต
D/C
แผนการรักษา Acute ST Elevation MI
Fast Track
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หนังสอยนยอม / ไมยนยอม การใหยาละลายล มเลอด
(Streptokinase)
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( p )
แนวทางการด แลผ ป วย
แพทยซักประวัตตรวจรางกาย ตรวจคล นไฟฟ าหัวใจ และ Non invasive procedure เพ อทาการวนจฉัยและวนจฉัยแยกโรค
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ภาวะหัวใจขาดเลอดเฉยบพลัน โรคหัวใจขาดเลอดเร อรัง
เหมาะสมก ับการให SK หรอไม
ST Elevation Non ST elevation
ใหยาละลายล มเลอด (SK)
เปดหลอดเลอดดวย SK ไดหรอไม
ICU / CCU
มภาวะแทรกซอนหรอไม
ตดตามและรักษาอย างต อเน อง
สงตอเพ อทา Invasive procedure
เหมาะสม
ได
ไมม
ไมเหมาะสม
ไมได
ม
แนวทางในการรับสงตอผ ป วย
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ส งต อกรเก นศกัยภาพในการดแล Contraindication of thrombolytic
Acute anterior wall MI killip >III
Cardiogenic shock Rescue PCI
รับดแลต อจากโรงพยาบาลชมชน
แนวทางการสงตอผ ป วย
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แบบฟอรมการสงตอผ ป วยโรคกลามเนอหัวใจตายเฉยบพลันชนด
STEMI ไปโรงพยาบาลชลบ ร
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แบบฟอรมการสงตอผ ป วยโรคกลามเนอหัวใจตายเฉยบพลันชนด
STEMI ในจังหวัดสม ทรปราการ
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ตัวชวัด
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1. รอยละของผ ป วย Acute STEMI ไดรับยาละลายล มเลอดภายใน 30นาท
2. รอยละการเสยชวตของผ ป วย Acute STEMI
3. รอยละการรอดชวตของผ ป วย Acute STEMI แบงตาม killip
classification
4. รอยละการเกด Major bleeding จากการไดรับยาละลายล มเลอด
ตัวชวัดเสรม
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1. ระยะเวลาเฉล ยผ ป วย Acute STEMI ท ไดรับยาละลายล มเลอดตั งแตมาถงโรงพยาบาลจนถงไดรับยา
2. รอยละของผ ป วย Acute STEMI ไดรับยาละลายล มเลอดภายใน 30
นาทเฉพาะในเวลาราชการ
3. Door to EKG time ภายใน 10 นาท
4. Door to Diagnosis time ภายใน 20 นาท