Elliott P, et al. JAMA 2009;302:37-48

Manhattan Plot of Results From the Combined Analysis of Genome-Wide Association Data

Elliott P, et al. JAMA 2009;302:37-48

Relationships Between Most Associated SNPs in the 5 Genetic Loci Associated With CRP Levels and Cardiovascular Risk Factors in Replication Sample (LOLIPOP, n = 13615) From Regression Analyses Adjusted for Age, Sex, and Ethnic

Group Under an Additive Genetic Modela

Elliott P, et al. JAMA 2009;302:37-48

Results of Mendelian

Randomization Experiment of

rs7553007 in the CRP Locus

(Present Study) With rs1130864

and rs1205 From Published

Studies

Elliott P, et al. JAMA 2009;302:37-48

Associations of SNPs rs1130864 and

rs1205 With CRP Levels, CRP Levels

With CHD, and SNPs With CHD

Prospective studies were included that reported all 3 analyses. CHD indicates coronary heart disease; CI, confidence interval; CRP, C-reactive protein; OR, odds ratio; SNPs, single-nucleotide polymorphisms.

Elliott P, et al. JAMA 2009;302:37-48

Meta-analysis of the Relationship of CRP Levels With CHD From Prospective Observational Studies

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Associations of SNPs in LEPR (rs6700896), IL6R (rs4537545), and HNF1A (rs1183910) Loci and APOE-CI-CII (rs4420638)

Cluster in the Genetic Association Study With CHD

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