Upload
jemimah-carter
View
213
Download
0
Embed Size (px)
Citation preview
Efficacy of ampicillin plus ceftriaxone vs ampicillin plus gentamicin for Enterococcus faecalis infective endocarditis (EFIE)
• Multi-centre, observational, non-randomised, comparative cohort study (Spain, Italy; 2005-2011): N=291 adult pts with EFIE
Fernández-Hidalgo N et al. Clin Infect Dis 2013;56:1261-8
1 of 2
Efficacy
Safety
•Subgroup of pts with EFIE caused by non-HLAR strains: similar results, except for septic paravalvular complications: AC: 40% - AG: 26% (P=0.050)
Efficacy of ampicillin plus ceftriaxone vs ampicillin plus gentamicin for Enterococcus faecalis infective endocarditis (EFIE)
AC seems to have a similar efficacy as AG for treating EFIE patients regardless of HLAR status, but may be less nephrotoxic
Fernández-Hidalgo N et al. Clin Infect Dis 2013;56:1261-8
2 of 2
Follow-up (FU) echocardiography after antibiotic therapy for infective endocarditis (IE): impact on retreatment of IE or cardiac valve surgery (CVS)
• Retrospective study (2005-2011): N=239 pts who survived initial treatment (Tx) for definite IE (Duke criteria)
Schutte KM. IDWeek 2013 abs. 621
1 of 2
Follow-up (FU) echocardiography after antibiotic therapy for infective endocarditis (IE): impact on retreatment of IE or cardiac valve surgery (CVS)
• In 44 pts with Sx + ECHO: significant correlation between new findings on ECHO and need for retreatment for IE and/or CVS: P=0.002
• In 23 pts requiring retreatment and/or CVS: TEE (71%) more sensitive than TTE (50%) for detecting worsening valve function or infection (P=0.0009)
• Valve type, location and infecting pathogen NOT significantly associated with need for retreatment or CVS
IE patients with Sx at post-Tx FU should undergo TEE to guide decisions regarding retreatment of IE and/or CVS
Schutte KM. IDWeek 2013 abs. 621
2 of 2