S73

EFFECTS OF STIMULATION OF THE STRIATUM AND GLOBUS PALLIDUS

ON LOCAL CEREBRAL GLUCOSE UTILIZATION IN RATS YASUTAKA AIKO I , SHINICHIRO HOSOKJ~WA 2, FUMIO SHIMA 2 and MOTOHIRO KATO 2

Department of Neurosurgery 1 and Neurophysiology2,Neurological Ins t i tu te , Faculty of Medicine, Kyushu University, 3-I-1, Maidashi, Higashiku,

Fukuoka, Japan

Changes in local cerebral g]ucose u t i l i za t ion (LCGU) induced by

electr ical stimulation of the striatum and globus pall idus were investigated

by means of the (14C) 2-deoxyglucose method. Stimulation of both the

striatum and globus pall idus increased LCGU in the globus pal l idus, ento-

peduncular nucleus and substantia nigra pars ret iculata on the stimulated

side, although the increase was greater during stimulation of the globus

pall idus. The substantia nigra pars compacta, subthalamic nucleus, lateral

habenula, some thalamic nuclei and the pedunculopontine tegmental nucleus

also showed increased LCGU on the stimulated side during stimulation of

the globus pall idus. These results suggest that LCGU ref lects the neuronal

ac t i v i t y of the structures d i rec t ly or ind i rect ly connected with the

stimulated structure, even i f they receive the inhibi tory inputs.